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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-139-5p SPP1 -1.53 0 3.18 0 miRanda -0.39 9.0E-5 NA
2 hsa-miR-335-5p SPP1 1.77 0 3.18 0 miRNAWalker2 validate -0.15 0.04004 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 TISSUE DEVELOPMENT 20 1518 2.04e-12 9.492e-09
2 HEART DEVELOPMENT 13 466 4.915e-12 1.144e-08
3 CARDIOVASCULAR SYSTEM DEVELOPMENT 15 788 1.829e-11 1.702e-08
4 CIRCULATORY SYSTEM DEVELOPMENT 15 788 1.829e-11 1.702e-08
5 REGULATION OF CELL PROLIFERATION 19 1496 1.787e-11 1.702e-08
6 POSITIVE REGULATION OF GENE EXPRESSION 20 1733 2.323e-11 1.802e-08
7 CELL DEVELOPMENT 18 1426 8.49e-11 5.643e-08
8 RESPONSE TO ENDOGENOUS STIMULUS 18 1450 1.117e-10 6.347e-08
9 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 19 1672 1.228e-10 6.347e-08
10 RESPONSE TO ORGANIC CYCLIC COMPOUND 15 917 1.539e-10 7.163e-08
11 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 9 207 3.012e-10 1.274e-07
12 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 19 1784 3.731e-10 1.447e-07
13 REPRODUCTIVE SYSTEM DEVELOPMENT 11 408 4.061e-10 1.453e-07
14 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 15 1008 5.728e-10 1.904e-07
15 TUBE DEVELOPMENT 12 552 6.608e-10 2.05e-07
16 RESPONSE TO HORMONE 14 893 1.293e-09 3.76e-07
17 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 13 750 1.745e-09 4.511e-07
18 REGULATION OF CELL DIFFERENTIATION 17 1492 1.694e-09 4.511e-07
19 NEGATIVE REGULATION OF CELL DIFFERENTIATION 12 609 2.01e-09 4.922e-07
20 EPITHELIUM DEVELOPMENT 14 945 2.682e-09 6.241e-07
21 RESPONSE TO STEROID HORMONE 11 497 3.22e-09 6.81e-07
22 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 15 1142 3.178e-09 6.81e-07
23 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 18 1805 3.873e-09 7.509e-07
24 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 13 801 3.859e-09 7.509e-07
25 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 18 1848 5.634e-09 1.008e-06
26 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 16 1395 5.595e-09 1.008e-06
27 REGULATION OF NEURON DIFFERENTIATION 11 554 9.927e-09 1.711e-06
28 RESPONSE TO ESTROGEN 8 218 1.229e-08 1.972e-06
29 REGULATION OF CELL DEATH 16 1472 1.205e-08 1.972e-06
30 RESPONSE TO LIPID 13 888 1.324e-08 2.054e-06
31 NEGATIVE REGULATION OF GENE EXPRESSION 16 1493 1.474e-08 2.213e-06
32 POSITIVE REGULATION OF CELL COMMUNICATION 16 1532 2.125e-08 3.09e-06
33 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 11 602 2.333e-08 3.29e-06
34 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 10 465 2.464e-08 3.372e-06
35 RESPONSE TO OXYGEN CONTAINING COMPOUND 15 1381 4.106e-08 5.459e-06
36 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 13 983 4.403e-08 5.691e-06
37 NEGATIVE REGULATION OF CELL PROLIFERATION 11 643 4.573e-08 5.751e-06
38 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 13 1004 5.643e-08 6.818e-06
39 POSITIVE REGULATION OF CELL DIFFERENTIATION 12 823 5.715e-08 6.818e-06
40 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 13 1021 6.869e-08 7.795e-06
41 REGULATION OF CELL DEVELOPMENT 12 836 6.783e-08 7.795e-06
42 ORGAN MORPHOGENESIS 12 841 7.24e-08 8.02e-06
43 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 7 190 1.07e-07 1.157e-05
44 CELLULAR RESPONSE TO HORMONE STIMULUS 10 552 1.227e-07 1.298e-05
45 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 15 1517 1.418e-07 1.434e-05
46 UROGENITAL SYSTEM DEVELOPMENT 8 299 1.415e-07 1.434e-05
47 REPRODUCTION 14 1297 1.456e-07 1.441e-05
48 POSITIVE REGULATION OF SMOOTHENED SIGNALING PATHWAY 4 24 1.567e-07 1.519e-05
49 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 11 740 1.892e-07 1.797e-05
50 CELL MATURATION 6 131 2.622e-07 2.346e-05
51 TUBE MORPHOGENESIS 8 323 2.55e-07 2.346e-05
52 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 6 131 2.622e-07 2.346e-05
53 RESPONSE TO GROWTH FACTOR 9 475 3.975e-07 3.489e-05
54 REGULATION OF GROWTH 10 633 4.341e-07 3.741e-05
55 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 15 1656 4.431e-07 3.749e-05
56 RESPONSE TO ESTRADIOL 6 146 4.972e-07 4.07e-05
57 REGULATION OF BMP SIGNALING PATHWAY 5 77 4.986e-07 4.07e-05
58 POSITIVE REGULATION OF RESPONSE TO STIMULUS 16 1929 5.207e-07 4.177e-05
59 REGULATION OF PROTEIN MODIFICATION PROCESS 15 1710 6.694e-07 5.279e-05
60 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 7 262 9.392e-07 7.172e-05
61 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 10 689 9.402e-07 7.172e-05
62 NEGATIVE REGULATION OF CELL DEATH 11 872 9.656e-07 7.247e-05
63 MORPHOGENESIS OF A BRANCHING STRUCTURE 6 167 1.093e-06 8.075e-05
64 GLAND DEVELOPMENT 8 395 1.165e-06 8.471e-05
65 EMBRYO DEVELOPMENT 11 894 1.233e-06 8.826e-05
66 MORPHOGENESIS OF AN EPITHELIUM 8 400 1.28e-06 8.89e-05
67 CELLULAR RESPONSE TO PEPTIDE 7 274 1.267e-06 8.89e-05
68 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 5 95 1.423e-06 9.738e-05
69 MYELOID LEUKOCYTE DIFFERENTIATION 5 96 1.499e-06 0.0001011
70 REGULATION OF EPITHELIAL CELL PROLIFERATION 7 285 1.646e-06 0.0001094
71 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 13 1360 1.832e-06 0.0001186
72 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 5 100 1.835e-06 0.0001186
73 LEUKOCYTE DIFFERENTIATION 7 292 1.934e-06 0.0001233
74 LUNG MORPHOGENESIS 4 45 2.131e-06 0.0001304
75 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 12 1152 2.094e-06 0.0001304
76 REGULATION OF PHOSPHORUS METABOLIC PROCESS 14 1618 2.124e-06 0.0001304
77 MYELOID CELL DIFFERENTIATION 6 189 2.247e-06 0.0001358
78 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 6 191 2.388e-06 0.0001424
79 NEGATIVE REGULATION OF CELL DEVELOPMENT 7 303 2.471e-06 0.0001455
80 DEVELOPMENTAL MATURATION 6 193 2.536e-06 0.0001475
81 NEUROGENESIS 13 1402 2.573e-06 0.0001478
82 CONNECTIVE TISSUE DEVELOPMENT 6 194 2.613e-06 0.0001483
83 RESPIRATORY SYSTEM DEVELOPMENT 6 197 2.856e-06 0.0001601
84 NEGATIVE REGULATION OF CELL COMMUNICATION 12 1192 2.988e-06 0.0001655
85 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 10 799 3.559e-06 0.0001949
86 VASCULATURE DEVELOPMENT 8 469 4.17e-06 0.0002256
87 POSITIVE REGULATION OF CELL DEVELOPMENT 8 472 4.371e-06 0.0002338
88 POSITIVE REGULATION OF CELL CYCLE 7 332 4.514e-06 0.0002387
89 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 13 1492 5.12e-06 0.0002647
90 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 6 218 5.119e-06 0.0002647
91 NEGATIVE REGULATION OF HEMOPOIESIS 5 128 6.184e-06 0.0003162
92 REGULATION OF REPRODUCTIVE PROCESS 5 129 6.424e-06 0.000323
93 CELL FATE COMMITMENT 6 227 6.455e-06 0.000323
94 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 6 229 6.788e-06 0.000336
95 CELLULAR RESPONSE TO NITROGEN COMPOUND 8 505 7.174e-06 0.0003514
96 REGULATION OF SMOOTHENED SIGNALING PATHWAY 4 62 7.779e-06 0.000377
97 RESPONSE TO ALCOHOL 7 362 7.949e-06 0.0003786
98 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 9 684 7.973e-06 0.0003786
99 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 7 365 8.388e-06 0.0003942
100 PLACENTA DEVELOPMENT 5 138 8.926e-06 0.0004153
101 TISSUE MORPHOGENESIS 8 533 1.063e-05 0.0004848
102 NEURON FATE COMMITMENT 4 67 1.061e-05 0.0004848
103 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 5 144 1.098e-05 0.0004911
104 REGULATION OF PROTEOLYSIS 9 711 1.088e-05 0.0004911
105 OSSIFICATION 6 251 1.145e-05 0.0005075
106 CARTILAGE DEVELOPMENT 5 147 1.213e-05 0.0005325
107 REGULATION OF CELL GROWTH 7 391 1.311e-05 0.0005701
108 REGULATION OF IMMUNE SYSTEM PROCESS 12 1403 1.583e-05 0.0006819
109 RESPONSE TO PEPTIDE 7 404 1.619e-05 0.0006912
110 BIOMINERAL TISSUE DEVELOPMENT 4 75 1.663e-05 0.0007033
111 EPITHELIAL TUBE BRANCHING INVOLVED IN LUNG MORPHOGENESIS 3 25 1.782e-05 0.0007471
112 IMMUNE SYSTEM DEVELOPMENT 8 582 2.006e-05 0.0008157
113 REGULATION OF T CELL DIFFERENTIATION IN THYMUS 3 26 2.012e-05 0.0008157
114 REGULATION OF THYMOCYTE AGGREGATION 3 26 2.012e-05 0.0008157
115 PATTERN SPECIFICATION PROCESS 7 418 2.016e-05 0.0008157
116 METANEPHROS DEVELOPMENT 4 81 2.256e-05 0.0009048
117 NEGATIVE REGULATION OF LEUKOCYTE DIFFERENTIATION 4 82 2.368e-05 0.0009417
118 GLUCOSE HOMEOSTASIS 5 170 2.447e-05 0.0009569
119 CARBOHYDRATE HOMEOSTASIS 5 170 2.447e-05 0.0009569
120 POSITIVE REGULATION OF CELL DEATH 8 605 2.648e-05 0.001027
121 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 7 437 2.68e-05 0.001031
122 EMBRYONIC HINDLIMB MORPHOGENESIS 3 29 2.816e-05 0.001065
123 REGULATION OF OLIGODENDROCYTE DIFFERENTIATION 3 29 2.816e-05 0.001065
124 RESPONSE TO CORTICOSTEROID 5 176 2.89e-05 0.001085
125 POSITIVE REGULATION OF CELL PROLIFERATION 9 814 3.179e-05 0.001183
126 SKELETAL SYSTEM DEVELOPMENT 7 455 3.468e-05 0.00128
127 REGULATION OF CELL ADHESION 8 629 3.493e-05 0.00128
128 POSITIVE REGULATION OF MOLECULAR FUNCTION 13 1791 3.664e-05 0.001332
129 REGULATION OF VESICLE MEDIATED TRANSPORT 7 462 3.821e-05 0.00135
130 POSITIVE REGULATION OF BMP SIGNALING PATHWAY 3 32 3.806e-05 0.00135
131 NEGATIVE REGULATION OF T CELL DIFFERENTIATION 3 32 3.806e-05 0.00135
132 REGIONALIZATION 6 311 3.831e-05 0.00135
133 RESPONSE TO BMP 4 94 4.056e-05 0.001408
134 CELLULAR RESPONSE TO BMP STIMULUS 4 94 4.056e-05 0.001408
135 PROTEIN AUTOPHOSPHORYLATION 5 192 4.381e-05 0.00151
136 GLAND MORPHOGENESIS 4 97 4.588e-05 0.001558
137 PROTEIN DESTABILIZATION 3 34 4.578e-05 0.001558
138 RESPONSE TO INORGANIC SUBSTANCE 7 479 4.804e-05 0.00162
139 REGULATION OF MAPK CASCADE 8 660 4.912e-05 0.001644
140 RESPONSE TO MONOAMINE 3 35 5e-05 0.001662
141 REGULATION OF ENDOCYTOSIS 5 199 5.195e-05 0.001714
142 CHEMICAL HOMEOSTASIS 9 874 5.534e-05 0.001801
143 NEURON DIFFERENTIATION 9 874 5.534e-05 0.001801
144 HOMEOSTATIC PROCESS 11 1337 5.586e-05 0.001805
145 CORONARY VASCULATURE DEVELOPMENT 3 37 5.919e-05 0.001886
146 HINDLIMB MORPHOGENESIS 3 37 5.919e-05 0.001886
147 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 6 337 5.986e-05 0.001895
148 REGULATION OF LEUKOCYTE PROLIFERATION 5 206 6.121e-05 0.001924
149 REGULATION OF FAT CELL DIFFERENTIATION 4 106 6.491e-05 0.002013
150 FAT CELL DIFFERENTIATION 4 106 6.491e-05 0.002013
151 PEPTIDYL TYROSINE AUTOPHOSPHORYLATION 3 39 6.942e-05 0.002139
152 HEART MORPHOGENESIS 5 212 7.012e-05 0.002147
153 NEGATIVE REGULATION OF LYMPHOCYTE DIFFERENTIATION 3 40 7.495e-05 0.002279
154 REGULATION OF OSTEOBLAST DIFFERENTIATION 4 112 8.044e-05 0.002424
155 PROSTATE GLAND DEVELOPMENT 3 41 8.075e-05 0.002424
156 POSITIVE REGULATION OF ENDOCYTOSIS 4 114 8.616e-05 0.00257
157 NEGATIVE REGULATION OF CELL ADHESION 5 223 8.904e-05 0.002639
158 POSITIVE REGULATION OF TRANSPORT 9 936 9.382e-05 0.002763
159 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 4 117 9.531e-05 0.002789
160 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 5 228 9.883e-05 0.002874
161 EMBRYONIC MORPHOGENESIS 7 539 0.0001008 0.002913
162 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 6 372 0.0001032 0.002963
163 REGULATION OF CELL CYCLE 9 949 0.0001042 0.002976
164 IMMUNE SYSTEM PROCESS 13 1984 0.0001062 0.003013
165 POSITIVE REGULATION OF CELL ADHESION 6 376 0.0001094 0.003085
166 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 9 957 0.0001111 0.003115
167 POSITIVE REGULATION OF PHAGOCYTOSIS 3 46 0.0001142 0.00318
168 NEGATIVE REGULATION OF GROWTH 5 236 0.0001162 0.00318
169 REGULATION OF CELL CELL ADHESION 6 380 0.0001159 0.00318
170 ENDOCRINE SYSTEM DEVELOPMENT 4 123 0.0001157 0.00318
171 REGULATION OF CELL MORPHOGENESIS 7 552 0.0001169 0.00318
172 KIDNEY EPITHELIUM DEVELOPMENT 4 125 0.0001231 0.003331
173 REGULATION OF CELL PROJECTION ORGANIZATION 7 558 0.000125 0.003362
174 OSTEOBLAST DIFFERENTIATION 4 126 0.000127 0.003395
175 REGULATION OF PEPTIDASE ACTIVITY 6 392 0.0001373 0.003652
176 CELL CELL SIGNALING 8 767 0.0001401 0.003704
177 REGULATION OF ADHERENS JUNCTION ORGANIZATION 3 50 0.0001466 0.003853
178 POSITIVE REGULATION OF CELL DIVISION 4 132 0.0001519 0.003971
179 POSITIVE REGULATION OF REPRODUCTIVE PROCESS 3 52 0.0001648 0.00426
180 NEGATIVE REGULATION OF T CELL PROLIFERATION 3 52 0.0001648 0.00426
181 REGULATION OF NEURON PROJECTION DEVELOPMENT 6 408 0.0001707 0.004388
182 NEGATIVE REGULATION OF CELL CELL ADHESION 4 138 0.0001803 0.004608
183 REGULATION OF TRANSPORT 12 1804 0.0001846 0.004695
184 ESTABLISHMENT OR MAINTENANCE OF CELL POLARITY 4 141 0.0001958 0.00495
185 PROTEIN MATURATION 5 265 0.0001995 0.005019
186 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 4 144 0.0002122 0.005309
187 POSITIVE REGULATION OF MEMBRANE INVAGINATION 2 11 0.0002229 0.005508
188 CELLULAR RESPONSE TO INSULIN STIMULUS 4 146 0.0002237 0.005508
189 POSITIVE REGULATION OF PHAGOCYTOSIS ENGULFMENT 2 11 0.0002229 0.005508
190 REGULATION OF GLIAL CELL DIFFERENTIATION 3 59 0.00024 0.005878
191 CHONDROCYTE DIFFERENTIATION 3 60 0.0002523 0.006083
192 REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 3 60 0.0002523 0.006083
193 OLIGODENDROCYTE DIFFERENTIATION 3 60 0.0002523 0.006083
194 RESPONSE TO EXTRACELLULAR STIMULUS 6 441 0.0002597 0.006229
195 EMBRYONIC DIGIT MORPHOGENESIS 3 61 0.000265 0.006246
196 POSITIVE REGULATION OF THYMOCYTE AGGREGATION 2 12 0.0002671 0.006246
197 REGULATION OF MESENCHYMAL CELL APOPTOTIC PROCESS 2 12 0.0002671 0.006246
198 POSITIVE REGULATION OF T CELL DIFFERENTIATION IN THYMUS 2 12 0.0002671 0.006246
199 POSITIVE REGULATION OF SODIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 2 12 0.0002671 0.006246
200 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 4 154 0.0002743 0.006349
201 NEGATIVE REGULATION OF MOLECULAR FUNCTION 9 1079 0.0002742 0.006349
202 CELLULAR RESPONSE TO INORGANIC SUBSTANCE 4 156 0.0002881 0.006636
203 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 9 1087 0.0002897 0.006639
204 REGULATION OF DEVELOPMENTAL GROWTH 5 289 0.0002979 0.006794
205 RESPONSE TO NITROGEN COMPOUND 8 859 0.0003033 0.006851
206 HORMONE MEDIATED SIGNALING PATHWAY 4 158 0.0003024 0.006851
207 CELLULAR RESPONSE TO LIPID 6 457 0.0003143 0.00692
208 WHITE FAT CELL DIFFERENTIATION 2 13 0.0003153 0.00692
209 POSITIVE REGULATION OF OLIGODENDROCYTE DIFFERENTIATION 2 13 0.0003153 0.00692
210 REGULATION OF PHAGOCYTOSIS ENGULFMENT 2 13 0.0003153 0.00692
211 MESENCHYMAL CELL PROLIFERATION 2 13 0.0003153 0.00692
212 REGULATION OF MEMBRANE INVAGINATION 2 13 0.0003153 0.00692
213 CENTRAL NERVOUS SYSTEM DEVELOPMENT 8 872 0.0003356 0.007331
214 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 8 876 0.0003461 0.007525
215 REGULATION OF EPITHELIAL CELL MIGRATION 4 166 0.0003648 0.007769
216 REGULATION OF CELL JUNCTION ASSEMBLY 3 68 0.0003653 0.007769
217 POSITIVE REGULATION OF MEIOTIC CELL CYCLE 2 14 0.0003673 0.007769
218 REGULATION OF PHAGOCYTOSIS 3 68 0.0003653 0.007769
219 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE I PROMOTER 2 14 0.0003673 0.007769
220 AMINOGLYCAN CATABOLIC PROCESS 3 68 0.0003653 0.007769
221 NEGATIVE REGULATION OF LEUKOCYTE PROLIFERATION 3 69 0.0003814 0.007965
222 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 4 168 0.0003818 0.007965
223 REGULATION OF AXONOGENESIS 4 168 0.0003818 0.007965
224 POSITIVE REGULATION OF NEURON DIFFERENTIATION 5 306 0.0003872 0.008038
225 APPENDAGE DEVELOPMENT 4 169 0.0003904 0.008038
226 LIMB DEVELOPMENT 4 169 0.0003904 0.008038
227 CELLULAR COMPONENT MORPHOGENESIS 8 900 0.0004148 0.008502
228 REGULATION OF CELL ACTIVATION 6 484 0.0004267 0.008557
229 NEGATIVE REGULATION OF TELOMERASE ACTIVITY 2 15 0.0004233 0.008557
230 REGULATION OF CELL SUBSTRATE ADHESION 4 173 0.0004266 0.008557
231 GRANULOCYTE DIFFERENTIATION 2 15 0.0004233 0.008557
232 NEGATIVE REGULATION OF ALPHA BETA T CELL DIFFERENTIATION 2 15 0.0004233 0.008557
233 SMOOTHENED SIGNALING PATHWAY 3 72 0.0004323 0.008633
234 REGULATION OF HEMOPOIESIS 5 314 0.0004356 0.008662
235 NEURON DEVELOPMENT 7 687 0.0004445 0.008801
236 PANCREAS DEVELOPMENT 3 73 0.0004502 0.008876
237 REGULATION OF OSSIFICATION 4 178 0.000475 0.009326
238 EPITHELIAL CELL DIFFERENTIATION 6 495 0.0004805 0.009395
239 ARTERY DEVELOPMENT 3 75 0.0004873 0.009488
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSCRIPTION FACTOR BINDING 9 524 9.016e-07 0.0004188
2 RECEPTOR BINDING 14 1476 7.065e-07 0.0004188
3 PROTEIN PHOSPHATASE BINDING 5 120 4.509e-06 0.0008377
4 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 9 629 4.046e-06 0.0008377
5 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 12 1199 3.175e-06 0.0008377
6 HORMONE BINDING 4 65 9.399e-06 0.001455
7 PHOSPHATASE BINDING 5 162 1.941e-05 0.002575
8 REGULATORY REGION NUCLEIC ACID BINDING 9 818 3.303e-05 0.003836
9 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 6 328 5.151e-05 0.005317
NumGOOverlapSizeP ValueAdj. P Value
1 PERINUCLEAR REGION OF CYTOPLASM 9 642 4.778e-06 0.00279
2 TRANSCRIPTION FACTOR COMPLEX 6 298 3.017e-05 0.00881

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Adherens_junction_hsa04520 3 72 0.0004323 0.01251
2 ErbB_signaling_pathway_hsa04012 3 85 0.0007028 0.01251
3 Focal_adhesion_hsa04510 4 199 0.000722 0.01251
4 Hedgehog_signaling_pathway_hsa04340 2 47 0.004181 0.05107
5 PI3K_Akt_signaling_pathway_hsa04151 4 352 0.005718 0.05107
6 VEGF_signaling_pathway_hsa04370 2 59 0.006516 0.05107
7 Mitophagy_animal_hsa04137 2 65 0.00786 0.05107
8 Rap1_signaling_pathway_hsa04015 3 206 0.00861 0.05107
9 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.008839 0.05107
10 TGF_beta_signaling_pathway_hsa04350 2 84 0.01285 0.06426
11 Endocytosis_hsa04144 3 244 0.01359 0.06426
12 HIF_1_signaling_pathway_hsa04066 2 100 0.01788 0.07748
13 MAPK_signaling_pathway_hsa04010 3 295 0.02241 0.08965
14 AMPK_signaling_pathway_hsa04152 2 121 0.02553 0.09122
15 Lysosome_hsa04142 2 123 0.02631 0.09122
16 Apelin_signaling_pathway_hsa04371 2 137 0.03209 0.09521
17 Apoptosis_hsa04210 2 138 0.03252 0.09521
18 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.03296 0.09521
19 Phospholipase_D_signaling_pathway_hsa04072 2 146 0.03605 0.09866
20 Tight_junction_hsa04530 2 170 0.04745 0.1234
21 cAMP_signaling_pathway_hsa04024 2 198 0.06217 0.1539

Quest ID: 390432ac2d146b989f08660b31ad6c47