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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-21-5p ABAT 4.38 0 -0.35 0.20779 MirTarget -0.18 0.00021 NA
2 hsa-miR-21-5p ABCA1 4.38 0 -0.92 1.0E-5 mirMAP -0.11 0.00319 NA
3 hsa-miR-21-5p ABCA10 4.38 0 -1.84 0 mirMAP -0.33 0 NA
4 hsa-miR-21-5p ACAT1 4.38 0 -0.65 0.00011 miRNAWalker2 validate -0.15 0 NA
5 hsa-miR-21-5p ACER3 4.38 0 -0.77 0 mirMAP -0.11 1.0E-5 NA
6 hsa-miR-21-5p ADCY2 4.38 0 -1.12 0.01473 MirTarget -0.42 0 NA
7 hsa-miR-196b-5p ADCY9 1.86 0.00094 -1.41 0 miRNATAP -0.12 0 NA
8 hsa-miR-9-5p ADCY9 4.99 0 -1.41 0 miRNATAP -0.1 0 NA
9 hsa-miR-9-5p AKAP13 4.99 0 -1.2 0 mirMAP -0.14 0 NA
10 hsa-miR-21-5p AKAP6 4.38 0 -0.99 0.00066 MirTarget -0.19 0.00015 NA
11 hsa-miR-21-5p ANKS1B 4.38 0 -1.5 0.00031 MirTarget -0.24 0.0009 NA
12 hsa-miR-21-5p APC 4.38 0 -0.81 0 miRNAWalker2 validate -0.14 0 23773491; 24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry
13 hsa-miR-21-5p APH1B 4.38 0 -1.16 0 MirTarget -0.25 0 NA
14 hsa-miR-21-5p APOLD1 4.38 0 -2.13 0 miRNAWalker2 validate -0.26 0 NA
15 hsa-miR-9-5p AR 4.99 0 -1.82 6.0E-5 miRNATAP -0.17 0 NA
16 hsa-miR-21-5p ARHGAP24 4.38 0 -1.71 0 MirTarget; miRNATAP -0.31 0 NA
17 hsa-miR-9-5p ARHGAP24 4.99 0 -1.71 0 MirTarget; miRNATAP -0.14 0 NA
18 hsa-miR-21-5p ARID4A 4.38 0 -0.6 0 miRNAWalker2 validate -0.13 0 NA
19 hsa-miR-21-5p ARMCX1 4.38 0 -1.25 0 MirTarget -0.21 0 NA
20 hsa-miR-21-5p ART4 4.38 0 -3.37 0 mirMAP -0.65 0 NA
21 hsa-miR-9-5p ATP11A 4.99 0 -0.3 0.27412 MirTarget; miRNATAP -0.12 0 NA
22 hsa-miR-9-5p ATP8A1 4.99 0 -1.09 0.00028 miRNATAP -0.16 0 NA
23 hsa-miR-21-5p ATRNL1 4.38 0 -1.11 0.02002 MirTarget -0.41 0 NA
24 hsa-miR-9-5p AXL 4.99 0 -1.36 0 miRNATAP -0.1 0 NA
25 hsa-miR-21-5p B3GALNT1 4.38 0 -1.52 0 miRNAWalker2 validate -0.23 0 NA
26 hsa-miR-21-5p BACE1 4.38 0 -0.8 0 mirMAP -0.14 0 NA
27 hsa-miR-21-5p BBS12 4.38 0 -0.56 6.0E-5 MirTarget -0.11 1.0E-5 NA
28 hsa-miR-21-5p BCL2 4.38 0 -0.49 0.06421 miRNAWalker2 validate; miRTarBase -0.2 1.0E-5 22964582; 21468550; 25994220; 25381586; 26555418; 23359184; 21376256 Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells
29 hsa-miR-21-5p BDH2 4.38 0 -0.83 0 miRNAWalker2 validate -0.13 1.0E-5 NA
30 hsa-miR-9-5p BEND7 4.99 0 -1.12 0.00101 mirMAP -0.14 0 NA
31 hsa-miR-21-5p BMP3 4.38 0 -1.37 0.01092 MirTarget -0.23 0.01448 NA
32 hsa-miR-9-5p BMPER 4.99 0 -3.66 0 miRNATAP -0.19 0 NA
33 hsa-miR-21-5p BMPR2 4.38 0 -1.25 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.2 0 NA
34 hsa-miR-21-5p BNC2 4.38 0 -1.12 1.0E-5 miRNATAP -0.15 0.00079 NA
35 hsa-miR-21-5p BOC 4.38 0 -0.77 0.00139 miRNAWalker2 validate -0.15 0.00036 NA
36 hsa-miR-21-5p BTBD3 4.38 0 -0.59 0.0005 miRNAWalker2 validate; miRNATAP -0.19 0 NA
37 hsa-miR-9-5p BTBD9 4.99 0 -0.39 0.05237 mirMAP -0.11 0 NA
38 hsa-miR-21-5p BTG2 4.38 0 -1.59 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.36 0 24821435 miR 21 regulates N methyl N nitro N' nitrosoguanidine induced gastric tumorigenesis by targeting FASLG and BTG2
39 hsa-miR-9-5p BTG2 4.99 0 -1.59 0 miRNATAP -0.17 0 NA
40 hsa-miR-9-5p C15orf52 4.99 0 -0.97 0.00029 mirMAP -0.14 0 NA
41 hsa-miR-9-5p C1QL3 4.99 0 -1.04 0.01034 miRNATAP -0.1 0.00138 NA
42 hsa-miR-9-5p CA13 4.99 0 -0.02 0.94174 miRNAWalker2 validate -0.12 0 NA
43 hsa-miR-196b-5p CACNB4 1.86 0.00094 -2.29 0 miRNATAP -0.11 7.0E-5 NA
44 hsa-miR-21-5p CADM2 4.38 0 -0.95 0.08706 mirMAP; miRNATAP -0.26 0.00841 NA
45 hsa-miR-21-5p CALD1 4.38 0 -0.85 2.0E-5 miRNAWalker2 validate; MirTarget -0.12 0.00065 NA
46 hsa-miR-21-5p CAMK4 4.38 0 -0.31 0.29837 mirMAP -0.11 0.03465 NA
47 hsa-miR-196b-5p CBFA2T3 1.86 0.00094 -1.5 0 MirTarget; miRNATAP -0.11 0 NA
48 hsa-miR-9-5p CBLN4 4.99 0 -1.56 0.00026 miRNATAP -0.12 0.00052 NA
49 hsa-miR-9-5p CBX7 4.99 0 -1.83 0 MirTarget -0.15 0 NA
50 hsa-miR-21-5p CCDC152 4.38 0 -1.45 0 mirMAP -0.23 0 NA
51 hsa-miR-21-5p CCNG1 4.38 0 -0.38 0.02147 miRNAWalker2 validate -0.13 1.0E-5 NA
52 hsa-miR-21-5p CCR1 4.38 0 -0.93 0.00022 miRNAWalker2 validate -0.12 0.00757 NA
53 hsa-miR-9-5p CD34 4.99 0 -1.95 0 miRNAWalker2 validate -0.14 0 NA
54 hsa-miR-21-5p CDK6 4.38 0 -0.63 0.01747 miRNAWalker2 validate; mirMAP -0.15 0.00158 NA
55 hsa-miR-196b-5p CELF2 1.86 0.00094 -1.51 0 miRNATAP -0.18 0 NA
56 hsa-miR-21-5p CEP68 4.38 0 -0.47 2.0E-5 miRNATAP -0.11 0 NA
57 hsa-miR-9-5p CHST9 4.99 0 -3.23 6.0E-5 miRNATAP -0.14 0.0351 NA
58 hsa-miR-21-5p CLIC2 4.38 0 -1.25 0 MirTarget -0.13 0.00625 NA
59 hsa-miR-21-5p CNTFR 4.38 0 -4.21 0 miRNATAP -0.79 0 NA
60 hsa-miR-9-5p CNTFR 4.99 0 -4.21 0 miRNATAP -0.23 0 NA
61 hsa-miR-9-5p CNTN3 4.99 0 -0.47 0.32664 MirTarget; miRNATAP -0.14 0.00024 NA
62 hsa-miR-9-5p CNTN4 4.99 0 -2.02 0 miRNATAP -0.13 0 NA
63 hsa-miR-21-5p COBLL1 4.38 0 -0.94 0 miRNAWalker2 validate -0.18 0 NA
64 hsa-miR-9-5p COLEC12 4.99 0 -2.36 0 miRNAWalker2 validate -0.23 0 NA
65 hsa-miR-21-5p CPEB3 4.38 0 -0.65 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.15 0 NA
66 hsa-miR-196b-5p CPM 1.86 0.00094 -1.24 0.00015 miRNATAP -0.12 1.0E-5 NA
67 hsa-miR-21-5p CREBL2 4.38 0 -0.66 0 miRNATAP -0.12 0 NA
68 hsa-miR-21-5p CRIM1 4.38 0 -1.64 0 miRNATAP -0.29 0 NA
69 hsa-miR-21-5p CRTC3 4.38 0 -0.61 0 mirMAP -0.11 0 NA
70 hsa-miR-21-5p CSRNP3 4.38 0 -0.53 0.17748 miRNATAP -0.24 0.00049 NA
71 hsa-miR-21-5p CXXC4 4.38 0 0.06 0.89857 mirMAP -0.22 0.00421 NA
72 hsa-miR-21-5p CYBRD1 4.38 0 -2.18 0 miRNAWalker2 validate -0.36 0 NA
73 hsa-miR-9-5p CYP39A1 4.99 0 -1.36 0.00021 miRNAWalker2 validate -0.11 0.00029 NA
74 hsa-miR-21-5p CYP4V2 4.38 0 -0.72 6.0E-5 miRNAWalker2 validate -0.14 0 NA
75 hsa-miR-21-5p DAAM1 4.38 0 -0.44 0.00894 miRNAWalker2 validate -0.13 1.0E-5 NA
76 hsa-miR-9-5p DAAM2 4.99 0 -1.64 0 mirMAP -0.18 0 NA
77 hsa-miR-21-5p DDR2 4.38 0 -1.72 0 miRNAWalker2 validate -0.31 0 NA
78 hsa-miR-9-5p DENND3 4.99 0 -1.91 0 MirTarget -0.11 0 NA
79 hsa-miR-21-5p DLGAP1 4.38 0 -1.8 0.00121 miRNATAP -0.46 0 NA
80 hsa-miR-9-5p DLX3 4.99 0 1.12 0.03167 miRNATAP -0.12 0.00497 NA
81 hsa-miR-21-5p DMD 4.38 0 -1.31 0 miRNAWalker2 validate -0.26 0 NA
82 hsa-miR-21-5p DOCK4 4.38 0 -1.77 0 miRNAWalker2 validate; miRTarBase -0.29 0 NA
83 hsa-miR-196b-5p DOK6 1.86 0.00094 -1.82 0 miRNATAP -0.14 0 NA
84 hsa-miR-21-5p DOK6 4.38 0 -1.82 0 mirMAP -0.41 0 NA
85 hsa-miR-9-5p DPP4 4.99 0 0.23 0.6118 miRNATAP -0.1 0.00467 NA
86 hsa-miR-21-5p DST 4.38 0 -1.47 0 mirMAP -0.16 0.00076 22403704 While the EDCs and estrogen similarly altered the expression of multiple microRNAs in MCF-7 cells including miR-21 differential patterns of microRNA expression were induced by DDT and BPA compared to estrogen
87 hsa-miR-21-5p DUSP8 4.38 0 -0.99 1.0E-5 miRNAWalker2 validate; MirTarget -0.13 0.00157 NA
88 hsa-miR-21-5p EDIL3 4.38 0 -1.63 2.0E-5 miRNAWalker2 validate; MirTarget -0.3 1.0E-5 NA
89 hsa-miR-9-5p EGR3 4.99 0 -1.83 0 mirMAP -0.11 1.0E-5 NA
90 hsa-miR-21-5p EIF4EBP2 4.38 0 -0.49 1.0E-5 miRNAWalker2 validate -0.12 0 NA
91 hsa-miR-21-5p EMP2 4.38 0 -2.84 0 mirMAP -0.43 0 NA
92 hsa-miR-9-5p EPAS1 4.99 0 -2.61 0 miRNATAP -0.13 0 NA
93 hsa-miR-196b-5p EPHA3 1.86 0.00094 -0.88 0.02443 MirTarget -0.17 0 NA
94 hsa-miR-21-5p EPM2A 4.38 0 -1.32 0 miRNAWalker2 validate -0.24 0 NA
95 hsa-miR-9-5p ERG 4.99 0 -2.41 0 miRNATAP -0.16 0 NA
96 hsa-miR-21-5p FAM26E 4.38 0 -1.3 0 mirMAP -0.19 0 NA
97 hsa-miR-21-5p FAM63B 4.38 0 -1.01 0 miRNATAP -0.17 0 NA
98 hsa-miR-9-5p FAT3 4.99 0 -3.31 0 mirMAP -0.15 2.0E-5 NA
99 hsa-miR-21-5p FBXL17 4.38 0 -0.58 1.0E-5 miRNAWalker2 validate; miRNATAP -0.13 0 NA
100 hsa-miR-21-5p FBXO3 4.38 0 -0.36 0.00195 miRNAWalker2 validate -0.11 0 NA
101 hsa-miR-21-5p FERMT2 4.38 0 -1.54 0 miRNAWalker2 validate -0.25 0 NA
102 hsa-miR-21-5p FGD4 4.38 0 -1.12 0 MirTarget -0.19 0 NA
103 hsa-miR-21-5p FGF18 4.38 0 -2.02 0 miRNATAP -0.45 0 NA
104 hsa-miR-9-5p FGF18 4.99 0 -2.02 0 miRNATAP -0.16 0 NA
105 hsa-miR-21-5p FGF2 4.38 0 -2.55 0 mirMAP -0.44 0 NA
106 hsa-miR-9-5p FGF9 4.99 0 -1.33 0.01194 miRNATAP -0.15 0.00028 NA
107 hsa-miR-21-5p FILIP1L 4.38 0 -1.01 2.0E-5 miRNAWalker2 validate -0.13 0.0026 NA
108 hsa-miR-9-5p FLI1 4.99 0 -1.88 0 MirTarget; miRNATAP -0.15 0 NA
109 hsa-miR-9-5p FLRT3 4.99 0 -2.43 0 MirTarget; miRNATAP -0.24 0 NA
110 hsa-miR-21-5p FMNL3 4.38 0 -0.7 0 mirMAP -0.1 7.0E-5 NA
111 hsa-miR-21-5p FMOD 4.38 0 -0.72 0.00334 miRNAWalker2 validate; miRTarBase -0.21 0 19906824; 23445447 Gain-of miR-21 function in MSMC and LSMC reduced TGF-beta-induced expression of fibromodulin and TGF-beta-induced factor P < 0.05 and moderately altered the rate of cell growth and caspase-3/7 activity in these cells;Our method exhibits ultrahigh sensitivity toward miR-21 with detection limits of 10 fM at 37 °C and 1 aM at 4 °C which corresponds to nine strands of miR-21 in a 15 μL sample and it is capable of distinguishing among miRNA family members
112 hsa-miR-9-5p FNIP2 4.99 0 -1.01 9.0E-5 MirTarget; miRNATAP -0.13 0 NA
113 hsa-miR-9-5p FOXF2 4.99 0 -1.7 0 miRNATAP -0.17 0 NA
114 hsa-miR-21-5p FOXN3 4.38 0 -0.95 0 miRNAWalker2 validate; mirMAP -0.19 0 NA
115 hsa-miR-9-5p FOXO1 4.99 0 -1.31 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.12 0 24870723; 25017439 Phosphorylation of Akt and forkhead box protein O1 FOXO1 was measured in cells with miR-9 overexpression or curcumin treatment; Western blot analysis showed that both miR-9 overexpression and curcumin similarly caused a significant p<0.05 decline in the phosphorylation of Akt and FOXO1 compared to untreated cells;In this study we explored whether FOXO1 3'UTR can function as a ceRNA in repressing epithelial-to-mesenchymal transition EMT and metastasis of breast cancer cells via regulating miR-9 activity; Follow-up analyses showed that there existed a competition of miR-9 between FOXO1 and E-cadherin-3'UTR
116 hsa-miR-21-5p FOXP2 4.38 0 -0.82 0.04073 mirMAP -0.2 0.00428 NA
117 hsa-miR-9-5p FREM1 4.99 0 -2.04 0 MirTarget -0.14 9.0E-5 NA
118 hsa-miR-21-5p FREM2 4.38 0 -2.05 3.0E-5 mirMAP -0.53 0 NA
119 hsa-miR-9-5p FREM2 4.99 0 -2.05 3.0E-5 MirTarget; miRNATAP -0.21 0 NA
120 hsa-miR-21-5p FRMD3 4.38 0 -3.32 0 MirTarget -0.62 0 NA
121 hsa-miR-9-5p FRMD4B 4.99 0 -1.33 0 miRNAWalker2 validate -0.11 0 NA
122 hsa-miR-9-5p FRY 4.99 0 -1.87 0 MirTarget; miRNATAP -0.17 0 NA
123 hsa-miR-21-5p FZD4 4.38 0 -1.79 0 mirMAP -0.29 0 NA
124 hsa-miR-21-5p GAS7 4.38 0 -1.49 0 mirMAP -0.21 0 NA
125 hsa-miR-196b-5p GATA6 1.86 0.00094 -2.27 0 MirTarget; miRNATAP -0.11 1.0E-5 NA
126 hsa-miR-21-5p GBP4 4.38 0 -1.47 0 mirMAP -0.17 0.00049 NA
127 hsa-miR-21-5p GFOD1 4.38 0 -1.96 0 mirMAP -0.36 0 NA
128 hsa-miR-9-5p GFRA1 4.99 0 -2.96 0 mirMAP -0.3 0 NA
129 hsa-miR-21-5p GNAQ 4.38 0 -1.17 0 miRNAWalker2 validate -0.2 0 NA
130 hsa-miR-9-5p GNAQ 4.99 0 -1.17 0 mirMAP -0.1 0 NA
131 hsa-miR-21-5p GNB4 4.38 0 -0.77 8.0E-5 miRNAWalker2 validate -0.11 0.00179 NA
132 hsa-miR-21-5p GNG2 4.38 0 -1.07 0 miRNATAP -0.2 0 NA
133 hsa-miR-9-5p GNG7 4.99 0 -1.41 0 mirMAP -0.16 0 NA
134 hsa-miR-21-5p GPD1L 4.38 0 -1.02 0 miRNAWalker2 validate -0.17 1.0E-5 NA
135 hsa-miR-9-5p GPR12 4.99 0 -0.27 0.6436 mirMAP -0.13 0.00338 NA
136 hsa-miR-196b-5p GPRASP1 1.86 0.00094 -1.22 0 MirTarget -0.1 0 NA
137 hsa-miR-21-5p GRIK3 4.38 0 -0.47 0.38036 mirMAP -0.22 0.02071 NA
138 hsa-miR-21-5p GTF2A1 4.38 0 -0.14 0.4882 miRNAWalker2 validate -0.12 0.00071 NA
139 hsa-miR-9-5p HEG1 4.99 0 -2.36 0 mirMAP -0.12 0 NA
140 hsa-miR-21-5p HHIP 4.38 0 -4.84 0 mirMAP -0.81 0 NA
141 hsa-miR-9-5p HHIP 4.99 0 -4.84 0 mirMAP -0.34 0 NA
142 hsa-miR-21-5p HIPK1 4.38 0 -0.53 2.0E-5 mirMAP -0.1 0 NA
143 hsa-miR-21-5p HIPK3 4.38 0 -1.01 0 MirTarget -0.22 0 NA
144 hsa-miR-196b-5p HLF 1.86 0.00094 -2.49 0 miRNATAP -0.32 0 NA
145 hsa-miR-21-5p HPS5 4.38 0 -1.17 0 miRNAWalker2 validate -0.17 0 NA
146 hsa-miR-21-5p HSD17B4 4.38 0 -1.05 0 MirTarget -0.21 0 NA
147 hsa-miR-9-5p HUNK 4.99 0 -0.71 0.06677 miRNATAP -0.12 0.00017 NA
148 hsa-miR-9-5p ID4 4.99 0 -2.44 0 miRNAWalker2 validate -0.17 0 NA
149 hsa-miR-21-5p IL1B 4.38 0 -1.42 1.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget -0.13 0.02018 NA
150 hsa-miR-9-5p IL33 4.99 0 -2.76 0 MirTarget -0.23 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF CELL DIFFERENTIATION 79 1492 4.168e-16 9.698e-13
2 TISSUE DEVELOPMENT 80 1518 3.389e-16 9.698e-13
3 CELL DEVELOPMENT 76 1426 1.203e-15 1.866e-12
4 CARDIOVASCULAR SYSTEM DEVELOPMENT 51 788 8.031e-14 7.474e-11
5 CIRCULATORY SYSTEM DEVELOPMENT 51 788 8.031e-14 7.474e-11
6 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 79 1672 2.004e-13 1.554e-10
7 VASCULATURE DEVELOPMENT 37 469 8.432e-13 5.605e-10
8 MUSCLE STRUCTURE DEVELOPMENT 34 432 7.963e-12 4.631e-09
9 HEAD DEVELOPMENT 44 709 1.913e-11 9.888e-09
10 EPITHELIUM DEVELOPMENT 52 945 2.204e-11 1.025e-08
11 TUBE DEVELOPMENT 38 552 2.497e-11 1.056e-08
12 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 79 1848 3.213e-11 1.246e-08
13 NEUROGENESIS 65 1402 9.163e-11 3.28e-08
14 ORGAN MORPHOGENESIS 47 841 1.335e-10 4.436e-08
15 REGULATION OF PHOSPHORUS METABOLIC PROCESS 70 1618 3.248e-10 1.008e-07
16 REGULATION OF CELL PROLIFERATION 66 1496 5.151e-10 1.498e-07
17 TISSUE MORPHOGENESIS 35 533 5.663e-10 1.526e-07
18 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 51 1004 5.903e-10 1.526e-07
19 RESPONSE TO ENDOGENOUS STIMULUS 64 1450 9.704e-10 2.376e-07
20 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 51 1021 1.051e-09 2.445e-07
21 CENTRAL NERVOUS SYSTEM DEVELOPMENT 46 872 1.369e-09 3.034e-07
22 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 73 1784 1.481e-09 3.133e-07
23 POSITIVE REGULATION OF GENE EXPRESSION 71 1733 2.48e-09 5.017e-07
24 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 39 689 3.947e-09 7.651e-07
25 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 68 1656 5.271e-09 9.811e-07
26 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 49 1008 5.608e-09 1.004e-06
27 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 21 229 6.086e-09 1.049e-06
28 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 59 1360 9.152e-09 1.521e-06
29 NEGATIVE REGULATION OF CELL COMMUNICATION 54 1192 9.925e-09 1.592e-06
30 CONNECTIVE TISSUE DEVELOPMENT 19 194 1.11e-08 1.722e-06
31 BEHAVIOR 32 516 1.266e-08 1.9e-06
32 RESPIRATORY SYSTEM DEVELOPMENT 19 197 1.428e-08 2.077e-06
33 PROTEIN PHOSPHORYLATION 46 944 1.6e-08 2.167e-06
34 RESPONSE TO OXYGEN CONTAINING COMPOUND 59 1381 1.59e-08 2.167e-06
35 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 52 1142 1.63e-08 2.167e-06
36 BLOOD VESSEL MORPHOGENESIS 26 364 1.858e-08 2.384e-06
37 REGULATION OF PROTEIN MODIFICATION PROCESS 68 1710 1.896e-08 2.384e-06
38 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 47 983 1.973e-08 2.416e-06
39 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 46 957 2.417e-08 2.884e-06
40 NEGATIVE REGULATION OF PHOSPHORYLATION 28 422 2.561e-08 2.979e-06
41 MUSCLE TISSUE DEVELOPMENT 22 275 3.21e-08 3.643e-06
42 REGULATION OF KINASE ACTIVITY 40 776 3.32e-08 3.678e-06
43 MUSCLE ORGAN DEVELOPMENT 22 277 3.655e-08 3.883e-06
44 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 32 541 3.839e-08 3.883e-06
45 NEURON DIFFERENTIATION 43 874 3.731e-08 3.883e-06
46 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 32 541 3.839e-08 3.883e-06
47 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 58 1395 5.531e-08 5.475e-06
48 POSITIVE REGULATION OF CELL DIFFERENTIATION 41 823 5.65e-08 5.477e-06
49 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 69 1805 6.874e-08 6.528e-06
50 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 40 799 7.282e-08 6.777e-06
51 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 34 616 7.586e-08 6.921e-06
52 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 40 801 7.784e-08 6.965e-06
53 CELL MOTILITY 41 835 8.37e-08 7.078e-06
54 LOCALIZATION OF CELL 41 835 8.37e-08 7.078e-06
55 CELLULAR COMPONENT MORPHOGENESIS 43 900 8.518e-08 7.078e-06
56 REGULATION OF CELLULAR COMPONENT MOVEMENT 39 771 8.186e-08 7.078e-06
57 ORGAN GROWTH 11 68 8.674e-08 7.081e-06
58 POSITIVE REGULATION OF CELL PROLIFERATION 40 814 1.192e-07 9.566e-06
59 LOCOMOTION 49 1114 1.275e-07 1.005e-05
60 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 30 513 1.329e-07 1.031e-05
61 KIDNEY EPITHELIUM DEVELOPMENT 14 125 1.834e-07 1.399e-05
62 GROWTH 26 410 1.984e-07 1.489e-05
63 IMMUNE SYSTEM DEVELOPMENT 32 582 2.03e-07 1.5e-05
64 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 53 1275 2.249e-07 1.635e-05
65 CARTILAGE DEVELOPMENT 15 147 2.303e-07 1.648e-05
66 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 46 1036 2.461e-07 1.684e-05
67 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 46 1036 2.461e-07 1.684e-05
68 MESENCHYME DEVELOPMENT 17 190 2.46e-07 1.684e-05
69 MUSCLE CELL DIFFERENTIATION 19 237 2.721e-07 1.835e-05
70 SKELETAL SYSTEM DEVELOPMENT 27 455 4.307e-07 2.855e-05
71 MESENCHYMAL CELL DIFFERENTIATION 14 134 4.356e-07 2.855e-05
72 MORPHOGENESIS OF AN EPITHELIUM 25 400 4.483e-07 2.897e-05
73 NEGATIVE REGULATION OF CELL DIFFERENTIATION 32 609 5.537e-07 3.529e-05
74 UROGENITAL SYSTEM DEVELOPMENT 21 299 5.848e-07 3.677e-05
75 CELL PROJECTION ORGANIZATION 41 902 6.412e-07 3.978e-05
76 SINGLE ORGANISM BEHAVIOR 24 384 7.641e-07 4.678e-05
77 PALATE DEVELOPMENT 11 85 8.941e-07 5.333e-05
78 DEVELOPMENTAL GROWTH 22 333 8.857e-07 5.333e-05
79 RESPONSE TO GROWTH FACTOR 27 475 9.917e-07 5.841e-05
80 POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 7 29 1.192e-06 6.934e-05
81 STEM CELL DIFFERENTIATION 16 190 1.251e-06 7.185e-05
82 BIOLOGICAL ADHESION 44 1032 1.364e-06 7.738e-05
83 NEURON PROJECTION DEVELOPMENT 29 545 1.488e-06 8.343e-05
84 ANGIOGENESIS 20 293 1.69e-06 9.364e-05
85 SENSORY ORGAN DEVELOPMENT 27 493 2.012e-06 0.0001101
86 REGULATION OF TRANSFERASE ACTIVITY 41 946 2.139e-06 0.0001157
87 PHOSPHORYLATION 49 1228 2.17e-06 0.0001161
88 REGULATION OF OSSIFICATION 15 178 2.663e-06 0.0001408
89 INTRACELLULAR SIGNAL TRANSDUCTION 58 1572 2.78e-06 0.0001454
90 REGULATION OF HOMEOSTATIC PROCESS 25 447 3.349e-06 0.0001731
91 POSITIVE REGULATION OF LOCOMOTION 24 420 3.655e-06 0.0001869
92 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 12 118 3.868e-06 0.0001956
93 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 8 48 4.078e-06 0.000204
94 CARDIAC MUSCLE TISSUE DEVELOPMENT 13 140 4.257e-06 0.0002107
95 NEGATIVE REGULATION OF CELL PROLIFERATION 31 643 4.956e-06 0.0002427
96 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 55 1492 5.347e-06 0.0002592
97 RESPONSE TO ACID CHEMICAL 20 319 6.125e-06 0.0002938
98 HEART DEVELOPMENT 25 466 6.922e-06 0.0003253
99 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 45 1135 6.901e-06 0.0003253
100 NEURON DEVELOPMENT 32 687 7.049e-06 0.000328
101 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 24 437 7.156e-06 0.0003297
102 TUBE MORPHOGENESIS 20 323 7.37e-06 0.0003362
103 REGULATION OF SYSTEM PROCESS 26 507 1.007e-05 0.0004551
104 CELLULAR RESPONSE TO ACID CHEMICAL 14 175 1.043e-05 0.0004665
105 REGULATION OF CELL DEVELOPMENT 36 836 1.063e-05 0.000471
106 ENDOTHELIUM DEVELOPMENT 10 90 1.131e-05 0.0004916
107 MESONEPHROS DEVELOPMENT 10 90 1.131e-05 0.0004916
108 CELL FATE COMMITMENT 16 227 1.238e-05 0.00053
109 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 33 740 1.242e-05 0.00053
110 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 8 56 1.338e-05 0.0005659
111 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 7 41 1.4e-05 0.0005869
112 REGULATION OF CHEMOTAXIS 14 180 1.437e-05 0.000597
113 NEPHRON EPITHELIUM DEVELOPMENT 10 93 1.515e-05 0.0006239
114 CELL GROWTH 12 135 1.552e-05 0.0006335
115 REGULATION OF EPITHELIAL CELL PROLIFERATION 18 285 1.614e-05 0.0006529
116 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 15 207 1.666e-05 0.0006681
117 REGULATION OF NEURON DIFFERENTIATION 27 554 1.691e-05 0.0006726
118 NEURON PROJECTION MORPHOGENESIS 22 402 1.82e-05 0.0007176
119 REGULATION OF DEVELOPMENTAL GROWTH 18 289 1.945e-05 0.0007542
120 EPITHELIAL CELL DIFFERENTIATION 25 495 1.929e-05 0.0007542
121 CARDIOCYTE DIFFERENTIATION 10 96 2.007e-05 0.0007719
122 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 25 498 2.133e-05 0.0008137
123 STEM CELL PROLIFERATION 8 60 2.249e-05 0.0008509
124 RENAL TUBULE DEVELOPMENT 9 78 2.287e-05 0.0008581
125 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 42 1087 2.616e-05 0.0009738
126 REGULATION OF EPITHELIAL CELL MIGRATION 13 166 2.695e-05 0.0009953
127 REGULATION OF ORGAN MORPHOGENESIS 16 242 2.728e-05 0.0009997
128 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 65 1977 2.798e-05 0.001017
129 EMBRYONIC MORPHOGENESIS 26 539 2.887e-05 0.001041
130 CELL PROLIFERATION 30 672 3.05e-05 0.001086
131 REGULATION OF AXONOGENESIS 13 168 3.057e-05 0.001086
132 FOREBRAIN DEVELOPMENT 20 357 3.136e-05 0.001106
133 SYNAPSE ORGANIZATION 12 145 3.178e-05 0.001112
134 RESPONSE TO ORGANIC CYCLIC COMPOUND 37 917 3.283e-05 0.00114
135 BLOOD VESSEL REMODELING 6 32 3.352e-05 0.001155
136 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 32 750 3.984e-05 0.001363
137 NEGATIVE REGULATION OF KINASE ACTIVITY 16 250 4.046e-05 0.001374
138 STRIATED MUSCLE CELL DIFFERENTIATION 13 173 4.155e-05 0.001393
139 POSITIVE REGULATION OF OSSIFICATION 9 84 4.16e-05 0.001393
140 CELLULAR RESPONSE TO LIPID 23 457 4.379e-05 0.001455
141 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 31 724 4.934e-05 0.001628
142 CELL JUNCTION ASSEMBLY 11 129 5.139e-05 0.001684
143 REGULATION OF MAPK CASCADE 29 660 5.496e-05 0.001788
144 RESPONSE TO WOUNDING 26 563 5.967e-05 0.001906
145 SYSTEM PROCESS 59 1785 5.98e-05 0.001906
146 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 11 131 5.917e-05 0.001906
147 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 9 88 6.025e-05 0.001907
148 REGULATION OF CELL DEATH 51 1472 6.232e-05 0.001959
149 CELL DIFFERENTIATION INVOLVED IN KIDNEY DEVELOPMENT 6 36 6.739e-05 0.002091
150 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 23 470 6.709e-05 0.002091
151 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 11 133 6.794e-05 0.002094
152 REGULATION OF MAP KINASE ACTIVITY 18 319 7.077e-05 0.002166
153 REGULATION OF OSTEOBLAST DIFFERENTIATION 10 112 7.616e-05 0.002316
154 SECOND MESSENGER MEDIATED SIGNALING 12 160 8.313e-05 0.002496
155 CELL JUNCTION ORGANIZATION 13 185 8.284e-05 0.002496
156 SEX DIFFERENTIATION 16 266 8.454e-05 0.002522
157 POSITIVE REGULATION OF CELL COMMUNICATION 52 1532 8.873e-05 0.00263
158 PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 4 13 9.303e-05 0.002705
159 CELLULAR RESPONSE TO GLUCAGON STIMULUS 6 38 9.239e-05 0.002705
160 POSITIVE REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 4 13 9.303e-05 0.002705
161 REGULATION OF ORGAN GROWTH 8 73 9.455e-05 0.002732
162 NEPHRON DEVELOPMENT 10 115 9.52e-05 0.002734
163 RESPONSE TO HORMONE 35 893 9.59e-05 0.002738
164 POSITIVE REGULATION OF KINASE ACTIVITY 23 482 9.785e-05 0.002747
165 EMBRYO DEVELOPMENT 35 894 9.802e-05 0.002747
166 RHYTHMIC PROCESS 17 298 9.799e-05 0.002747
167 CARDIAC MUSCLE CELL DIFFERENTIATION 8 74 0.0001042 0.002903
168 CELL SUBSTRATE ADHESION 12 164 0.0001053 0.002917
169 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 13 190 0.0001085 0.002987
170 MULTICELLULAR ORGANISMAL HOMEOSTASIS 16 272 0.0001097 0.003001
171 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 12 166 0.0001182 0.003216
172 NEGATIVE REGULATION OF CELL DEVELOPMENT 17 303 0.0001198 0.003242
173 CELL MATRIX ADHESION 10 119 0.0001267 0.003409
174 REGULATION OF HEART CONTRACTION 14 221 0.0001353 0.003592
175 REGULATION OF ION TRANSPORT 26 592 0.0001344 0.003592
176 POSITIVE REGULATION OF CHEMOTAXIS 10 120 0.0001359 0.003592
177 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 18 337 0.0001414 0.003635
178 EAR DEVELOPMENT 13 195 0.0001408 0.003635
179 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 16 278 0.0001411 0.003635
180 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 11 144 0.0001388 0.003635
181 REGULATION OF MUSCLE SYSTEM PROCESS 13 195 0.0001408 0.003635
182 LUNG ALVEOLUS DEVELOPMENT 6 41 0.0001432 0.00366
183 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 19 368 0.0001444 0.003673
184 COGNITION 15 251 0.0001503 0.003795
185 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 9 99 0.0001509 0.003795
186 POSITIVE REGULATION OF HEART GROWTH 5 27 0.0001653 0.004026
187 REGULATION OF TRANSPORTER ACTIVITY 13 198 0.0001638 0.004026
188 RESPONSE TO OXYGEN LEVELS 17 311 0.0001637 0.004026
189 REGULATION OF RYANODINE SENSITIVE CALCIUM RELEASE CHANNEL ACTIVITY 5 27 0.0001653 0.004026
190 REGULATION OF HEART GROWTH 6 42 0.0001643 0.004026
191 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 9 100 0.000163 0.004026
192 NEGATIVE REGULATION OF GENE EXPRESSION 50 1493 0.0001696 0.004111
193 CHONDROCYTE DIFFERENTIATION 7 60 0.0001743 0.004181
194 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 7 60 0.0001743 0.004181
195 POSITIVE REGULATION OF MAPK CASCADE 22 470 0.0001815 0.00433
196 RESPONSE TO LIPID 34 888 0.0001875 0.004429
197 TELENCEPHALON DEVELOPMENT 14 228 0.0001874 0.004429
198 SKELETAL SYSTEM MORPHOGENESIS 13 201 0.0001901 0.004467
199 REPRODUCTIVE SYSTEM DEVELOPMENT 20 408 0.0001942 0.004541
200 METANEPHROS DEVELOPMENT 8 81 0.0001973 0.004583
201 LONG TERM MEMORY 5 28 0.000198 0.004583
202 REGULATION OF MUSCLE TISSUE DEVELOPMENT 9 103 0.0002042 0.004634
203 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 9 103 0.0002042 0.004634
204 REGULATION OF MUSCLE ORGAN DEVELOPMENT 9 103 0.0002042 0.004634
205 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 10 126 0.0002032 0.004634
206 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 9 104 0.0002197 0.004962
207 REGULATION OF MUSCLE CELL DIFFERENTIATION 11 152 0.0002234 0.005021
208 REGULATION OF DEVELOPMENTAL PIGMENTATION 4 16 0.0002259 0.005054
209 REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 5 29 0.0002354 0.00519
210 NEUROBLAST PROLIFERATION 5 29 0.0002354 0.00519
211 REGULATION OF VASCULATURE DEVELOPMENT 14 233 0.0002344 0.00519
212 LUNG MORPHOGENESIS 6 45 0.0002427 0.005326
213 POSITIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 8 84 0.000254 0.005523
214 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 8 84 0.000254 0.005523
215 POSITIVE REGULATION OF RESPONSE TO STIMULUS 60 1929 0.000271 0.005864
216 SMOOTH MUSCLE CELL DIFFERENTIATION 5 30 0.0002779 0.005866
217 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 8 85 0.0002757 0.005866
218 BONE DEVELOPMENT 11 156 0.0002799 0.005866
219 RESPONSE TO KETONE 12 182 0.0002791 0.005866
220 REGULATION OF METAL ION TRANSPORT 17 325 0.0002748 0.005866
221 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 11 156 0.0002799 0.005866
222 REGULATION OF BLOOD CIRCULATION 16 295 0.0002764 0.005866
223 REGULATION OF MYELOID CELL DIFFERENTIATION 12 183 0.0002934 0.006123
224 SENSORY ORGAN MORPHOGENESIS 14 239 0.000304 0.006314
225 REGULATION OF CELL ADHESION 26 629 0.0003447 0.007128
226 RESPONSE TO GLUCAGON 6 48 0.0003478 0.00713
227 REGULATION OF SODIUM ION TRANSMEMBRANE TRANSPORT 6 48 0.0003478 0.00713
228 SMOOTH MUSCLE TISSUE DEVELOPMENT 4 18 0.0003682 0.007513
229 CELL PART MORPHOGENESIS 26 633 0.0003794 0.007709
230 CIRCULATORY SYSTEM PROCESS 18 366 0.000386 0.007809
231 POSITIVE REGULATION OF MOLECULAR FUNCTION 56 1791 0.0003898 0.007819
232 GLOMERULUS DEVELOPMENT 6 49 0.0003899 0.007819
233 MYELOID CELL DIFFERENTIATION 12 189 0.0003936 0.00786
234 TAXIS 21 464 0.0003961 0.007876
235 SKELETAL MUSCLE ORGAN DEVELOPMENT 10 137 0.0003994 0.007908
236 CELL DEATH 36 1001 0.0004012 0.00791
237 REGULATION OF STEM CELL DIFFERENTIATION 9 113 0.0004087 0.008025
238 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 25 602 0.0004171 0.008145
239 POSITIVE REGULATION OF AXONOGENESIS 7 69 0.0004184 0.008145
240 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 12 191 0.0004328 0.008391
241 REGULATION OF ENDOTHELIAL CELL MIGRATION 9 114 0.0004362 0.008422
242 REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 4 19 0.0004591 0.008755
243 NEURAL PRECURSOR CELL PROLIFERATION 7 70 0.0004571 0.008755
244 POSITIVE REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 4 19 0.0004591 0.008755
245 REGULATION OF CALCIUM ION TRANSPORT INTO CYTOSOL 8 92 0.0004731 0.008985
246 REGULATION OF BODY FLUID LEVELS 22 506 0.0004995 0.009431
247 MORPHOGENESIS OF A BRANCHING STRUCTURE 11 167 0.0005006 0.009431
248 ADHERENS JUNCTION ASSEMBLY 5 34 0.0005086 0.009504
249 RENAL WATER HOMEOSTASIS 5 34 0.0005086 0.009504
250 REGULATION OF NEURON PROJECTION DEVELOPMENT 19 408 0.0005252 0.009775
251 ENDOTHELIAL CELL DIFFERENTIATION 7 72 0.0005431 0.009936
252 REGULATION OF HEMOPOIESIS 16 314 0.0005488 0.009936
253 ACTION POTENTIAL 8 94 0.0005468 0.009936
254 RESPONSE TO BMP 8 94 0.0005468 0.009936
255 SMOOTHENED SIGNALING PATHWAY 7 72 0.0005431 0.009936
256 CELLULAR RESPONSE TO BMP STIMULUS 8 94 0.0005468 0.009936
257 POSITIVE REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 6 52 0.0005401 0.009936
258 APPENDAGE DEVELOPMENT 11 169 0.0005534 0.009941
259 LIMB DEVELOPMENT 11 169 0.0005534 0.009941
NumGOOverlapSizeP ValueAdj. P Value
1 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 36 629 1.221e-08 1.134e-05
2 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 23 315 8.393e-08 2.599e-05
3 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 52 1199 7.875e-08 2.599e-05
4 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 22 328 6.872e-07 0.0001277
5 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 18 226 6.18e-07 0.0001277
6 ENZYME BINDING 63 1737 1.712e-06 0.000265
7 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 10 81 4.346e-06 0.0005237
8 PROTEIN KINASE ACTIVITY 31 640 4.51e-06 0.0005237
9 RECEPTOR BINDING 54 1476 8.175e-06 0.0008439
10 ACTIN BINDING 22 393 1.283e-05 0.001084
11 KINASE ACTIVITY 36 842 1.241e-05 0.001084
12 MOLECULAR FUNCTION REGULATOR 49 1353 2.91e-05 0.002253
13 KINASE BINDING 27 606 7.885e-05 0.005232
14 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 38 992 7.732e-05 0.005232
15 CYTOKINE BINDING 9 92 8.548e-05 0.005294
16 GROWTH FACTOR BINDING 10 123 0.0001667 0.009678
NumGOOverlapSizeP ValueAdj. P Value
1 PLASMA MEMBRANE REGION 43 929 2.045e-07 6.346e-05
2 MEMBRANE REGION 49 1134 2.173e-07 6.346e-05
3 INTRINSIC COMPONENT OF PLASMA MEMBRANE 61 1649 1.354e-06 0.0002636
4 SYNAPSE 34 754 7.226e-06 0.001055
5 NEURON PART 47 1265 2.276e-05 0.001888
6 AXON 22 418 3.293e-05 0.001888
7 AXONAL GROWTH CONE 5 20 3.557e-05 0.001888
8 NEURON PROJECTION 38 942 2.571e-05 0.001888
9 CELL SURFACE 33 757 1.965e-05 0.001888
10 CELL PROJECTION 60 1786 3.217e-05 0.001888
11 PLASMA MEMBRANE PROTEIN COMPLEX 25 510 3.162e-05 0.001888
12 POSTSYNAPSE 20 378 6.955e-05 0.003385
13 CELL JUNCTION 42 1151 9.534e-05 0.004283
14 SYNAPSE PART 26 610 0.0002151 0.00895
15 SYNAPTIC MEMBRANE 15 261 0.0002299 0.00895

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Apelin_signaling_pathway_hsa04371 14 137 5.72e-07 2.974e-05
2 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 12 139 2.084e-05 0.0005419
3 Rap1_signaling_pathway_hsa04015 14 206 6.398e-05 0.001109
4 Wnt_signaling_pathway_hsa04310 10 146 0.0006593 0.007088
5 PI3K_Akt_signaling_pathway_hsa04151 17 352 0.0006816 0.007088
6 Hippo_signaling_pathway_hsa04390 10 154 0.000995 0.008623
7 cGMP_PKG_signaling_pathway_hsa04022 10 163 0.001528 0.01135
8 Ras_signaling_pathway_hsa04014 12 232 0.00232 0.01508
9 Cellular_senescence_hsa04218 9 160 0.004606 0.02661
10 MAPK_signaling_pathway_hsa04010 13 295 0.006071 0.03011
11 TGF_beta_signaling_pathway_hsa04350 6 84 0.006369 0.03011
12 Regulation_of_actin_cytoskeleton_hsa04810 10 208 0.008579 0.03604
13 Sphingolipid_signaling_pathway_hsa04071 7 118 0.009009 0.03604
14 Calcium_signaling_pathway_hsa04020 9 182 0.01039 0.03858
15 Hedgehog_signaling_pathway_hsa04340 4 47 0.0137 0.04749
16 Cytokine_cytokine_receptor_interaction_hsa04060 11 270 0.0189 0.06144
17 Gap_junction_hsa04540 5 88 0.03027 0.09258
18 Oocyte_meiosis_hsa04114 6 124 0.0366 0.1057
19 Focal_adhesion_hsa04510 8 199 0.04452 0.1218
20 Phospholipase_D_signaling_pathway_hsa04072 6 146 0.06995 0.1819
21 ECM_receptor_interaction_hsa04512 4 82 0.07919 0.1876
22 mTOR_signaling_pathway_hsa04150 6 151 0.07937 0.1876
23 cAMP_signaling_pathway_hsa04024 7 198 0.09844 0.222
24 Jak_STAT_signaling_pathway_hsa04630 6 162 0.1025 0.222
25 HIF_1_signaling_pathway_hsa04066 4 100 0.1361 0.2831
26 p53_signaling_pathway_hsa04115 3 68 0.1511 0.3021
27 Phagosome_hsa04145 5 152 0.1827 0.3519
28 ABC_transporters_hsa02010 2 45 0.2229 0.414
29 Notch_signaling_pathway_hsa04330 2 48 0.2449 0.4391
30 FoxO_signaling_pathway_hsa04068 4 132 0.2644 0.4582
31 NF_kappa_B_signaling_pathway_hsa04064 3 95 0.2894 0.4855
32 Phosphatidylinositol_signaling_system_hsa04070 3 99 0.311 0.4977
33 Cell_adhesion_molecules_.CAMs._hsa04514 4 145 0.3218 0.4977
34 VEGF_signaling_pathway_hsa04370 2 59 0.3254 0.4977
35 TNF_signaling_pathway_hsa04668 3 108 0.3597 0.5344
36 Necroptosis_hsa04217 4 164 0.4069 0.5713
37 Adherens_junction_hsa04520 2 72 0.4174 0.5713
38 AMPK_signaling_pathway_hsa04152 3 121 0.4289 0.5713
39 Tight_junction_hsa04530 4 170 0.4334 0.5713
40 Autophagy_animal_hsa04140 3 128 0.4651 0.5899
41 Cell_cycle_hsa04110 2 124 0.7061 0.8427
42 Endocytosis_hsa04144 4 244 0.713 0.8427
43 Apoptosis_hsa04210 2 138 0.7601 0.8783
44 Neuroactive_ligand_receptor_interaction_hsa04080 3 278 0.9147 0.9707

Quest ID: 39171c9c7eedaadf3e32c8a13c2a4dcf