Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

GRN in network:

Notice: IE browser need to manually refresh (F5) this page after resetting the network.

This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-18a-5p ABR 2.3 0 -0.31 0.60278 miRNAWalker2 validate; mirMAP -0.11 0 NA
2 hsa-miR-18a-5p ADAMTS2 2.3 0 -0.29 0.51167 mirMAP -0.15 0 NA
3 hsa-miR-18a-5p AFF4 2.3 0 -0.7 0.2756 miRNAWalker2 validate -0.22 0 NA
4 hsa-miR-18a-5p ALCAM 2.3 0 -1.44 0.0323 MirTarget; miRNATAP -0.34 0 NA
5 hsa-miR-18a-5p ANKRD50 2.3 0 -0.73 0.17675 MirTarget; miRNATAP -0.18 0 NA
6 hsa-miR-18a-5p APOLD1 2.3 0 -0.38 0.4521 mirMAP -0.16 0 NA
7 hsa-miR-18a-5p ARFGEF2 2.3 0 -0.4 0.50575 MirTarget -0.12 0 NA
8 hsa-miR-18a-5p ARHGAP5 2.3 0 -0.05 0.93513 MirTarget -0.12 0 NA
9 hsa-miR-18a-5p ARL15 2.3 0 -0.82 0.02217 MirTarget; miRNATAP -0.26 0 NA
10 hsa-miR-18a-5p ASTN1 2.3 0 0.11 0.73119 MirTarget -0.25 0 NA
11 hsa-miR-18a-5p ASXL2 2.3 0 -0.04 0.92196 miRNATAP -0.17 0 NA
12 hsa-miR-18a-5p ATF7 2.3 0 -0.31 0.57742 mirMAP -0.14 0 NA
13 hsa-miR-18a-5p ATM 2.3 0 -0.05 0.92324 miRNAWalker2 validate; miRTarBase; MirTarget -0.12 0 23857602; 23437304; 25963391; 23229340 Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases
14 hsa-miR-18a-5p ATP1B2 2.3 0 -0.53 0.01045 mirMAP -0.23 0 NA
15 hsa-miR-18a-5p ATP2B1 2.3 0 -0.32 0.5434 miRNATAP -0.12 0 NA
16 hsa-miR-18a-5p ATP2C2 2.3 0 -0.99 0.0117 MirTarget -0.2 0 NA
17 hsa-miR-18a-5p ATXN1 2.3 0 -0.48 0.35126 MirTarget; miRNATAP -0.16 0 NA
18 hsa-miR-18a-5p BBX 2.3 0 -0.06 0.91654 MirTarget; miRNATAP -0.11 0 NA
19 hsa-miR-18a-5p BHLHE22 2.3 0 0.39 0.0481 MirTarget; miRNATAP -0.1 0.00101 NA
20 hsa-miR-18a-5p C1orf21 2.3 0 -1.31 0.03763 mirMAP -0.35 0 NA
21 hsa-miR-18a-5p C1orf226 2.3 0 -0.84 0.08628 mirMAP -0.29 0 NA
22 hsa-miR-18a-5p C5orf30 2.3 0 -1.64 0.00035 miRNATAP -0.22 0 NA
23 hsa-miR-18a-5p CA12 2.3 0 -4.61 0 miRNAWalker2 validate; MirTarget -0.85 0 NA
24 hsa-miR-18a-5p CACNG4 2.3 0 -3.36 0 mirMAP -0.48 0 NA
25 hsa-miR-18a-5p CALN1 2.3 0 -1.14 0.00178 mirMAP -0.42 0 NA
26 hsa-miR-18a-5p CAMK2B 2.3 0 -1.56 0 mirMAP -0.27 0 NA
27 hsa-miR-18a-5p CAMK2N1 2.3 0 -1.69 0.00251 miRNATAP -0.3 0 NA
28 hsa-miR-18a-5p CASZ1 2.3 0 -0.88 0.0914 mirMAP -0.22 0 NA
29 hsa-miR-18a-5p CDON 2.3 0 -0.93 0.03701 mirMAP -0.27 0 NA
30 hsa-miR-18a-5p CLASP2 2.3 0 -0.44 0.39581 miRNATAP -0.14 0 NA
31 hsa-miR-18a-5p CREBL2 2.3 0 -0.55 0.34569 miRNAWalker2 validate; MirTarget; miRNATAP -0.19 0 NA
32 hsa-miR-18a-5p CRIM1 2.3 0 -0.31 0.6343 MirTarget; miRNATAP -0.27 0 NA
33 hsa-miR-18a-5p CSNK1G1 2.3 0 -0.46 0.31306 mirMAP -0.11 0 NA
34 hsa-miR-18a-5p CSRNP3 2.3 0 -0.3 0.37119 miRNAWalker2 validate; miRNATAP -0.36 0 NA
35 hsa-miR-18a-5p CTDSPL 2.3 0 -0.41 0.46081 miRNAWalker2 validate; MirTarget; miRNATAP -0.16 0 NA
36 hsa-miR-18a-5p CTGF 2.3 0 -0.22 0.78118 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.12 2.0E-5 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling
37 hsa-miR-18a-5p CYP4F11 2.3 0 -2.83 0 MirTarget -0.61 0 NA
38 hsa-miR-18a-5p DAAM2 2.3 0 -0.04 0.92488 miRNAWalker2 validate -0.13 0 NA
39 hsa-miR-18a-5p DCUN1D3 2.3 0 -0.21 0.50418 miRNAWalker2 validate -0.12 0 NA
40 hsa-miR-18a-5p DICER1 2.3 0 -0.3 0.60913 miRNAWalker2 validate -0.14 0 27338043; 21935572 MiR 18a upregulation decreases Dicer expression and confers paclitaxel resistance in triple negative breast cancer; In this study we investigated the association among miR-18a dysregulation Dicer dysregulation and paclitaxel PTX resistance in TNBC cells; The influence of miR-18a overexpression on Dicer expression was measured by qRT-PCR and Western blot analysis; MiR-18a overexpression directly led to Dicer repression at mRNA and protein level; This study found that miR-18a is an important miRNA that suppresses Dicer expression and increases PTX resistance in TNBC cells;microRNA 18a a member of the oncogenic miR 17 92 cluster targets Dicer and suppresses cell proliferation in bladder cancer T24 cells; Furthermore ectopic expression of miR-18a in T24 cells down-regulated Dicer expression at both the mRNA and protein level while inhibition miR-18a by antisense oligonucleotides could enhance Dicer expression in T24 cells; Two binding sites of miR-18a were found in Dicer 3' untranslated region 3' UTR; In addition knockdown of Dicer expression by siRNA mimicked cell growth suppression induced by miR-18a in T24 cells; These results show that miR-18a functions as a tumor suppressor by targeting Dicer in bladder cancer T24 cells and revealed a noteworthy feedback loop which may be utilized by the miR-17-92 cluster to control miRNA output and prevent its overexpression
41 hsa-miR-18a-5p DNAJC16 2.3 0 -0.57 0.21774 MirTarget -0.15 0 NA
42 hsa-miR-18a-5p DOCK4 2.3 0 0.07 0.86467 MirTarget -0.11 0 NA
43 hsa-miR-18a-5p DPY19L3 2.3 0 -0.54 0.15711 MirTarget -0.18 0 NA
44 hsa-miR-18a-5p DST 2.3 0 0.02 0.98236 mirMAP -0.25 0 NA
45 hsa-miR-18a-5p ESR1 2.3 0 -6.15 0 miRNAWalker2 validate; miRTarBase; miRNATAP -1.14 0 19027010; 24975878 MicroRNA 18a prevents estrogen receptor alpha expression promoting proliferation of hepatocellular carcinoma cells; The gene ESR1 which encodes the estrogen receptor-alpha ERalpha was identified as a target of miR-18a miR-18a can repress ERalpha translation by binding to its mRNA at the 3' untranslated region;Elevated p53 promotes the processing of miR 18a to decrease estrogen receptor α in female hepatocellular carcinoma; Our previous study identified that estrogen receptor alpha ERα protein is downregulated in 60% of female HCC cases via a miR-18a elevation mediated suppression of ERα translation
46 hsa-miR-18a-5p F3 2.3 0 -0.07 0.88241 MirTarget -0.22 0 NA
47 hsa-miR-18a-5p FAIM2 2.3 0 -1.17 0.0002 mirMAP -0.37 0 NA
48 hsa-miR-18a-5p FAM166B 2.3 0 -0.21 0.42685 MirTarget -0.14 0.00112 NA
49 hsa-miR-18a-5p FAM168A 2.3 0 -0.04 0.90735 mirMAP -0.12 0 NA
50 hsa-miR-18a-5p FAM196A 2.3 0 -2.86 0 MirTarget -0.56 0 NA
51 hsa-miR-18a-5p FBP1 2.3 0 -2.6 0 MirTarget -0.5 0 NA
52 hsa-miR-18a-5p FEM1C 2.3 0 -0.62 0.20954 miRNAWalker2 validate -0.17 0 NA
53 hsa-miR-18a-5p FGF1 2.3 0 -0.65 0.10119 MirTarget -0.31 0 NA
54 hsa-miR-18a-5p FNDC3A 2.3 0 -0.25 0.65712 miRNATAP -0.15 0 NA
55 hsa-miR-18a-5p FRS2 2.3 0 -1.13 0.03077 MirTarget -0.26 0 NA
56 hsa-miR-18a-5p FRYL 2.3 0 -0.45 0.40277 miRNATAP -0.15 0 NA
57 hsa-miR-18a-5p GAB1 2.3 0 -0.51 0.28626 MirTarget; miRNATAP -0.18 0 NA
58 hsa-miR-18a-5p GAS7 2.3 0 -0.45 0.39346 mirMAP -0.26 0 NA
59 hsa-miR-18a-5p GLRB 2.3 0 -1.38 4.0E-5 MirTarget; miRNATAP -0.42 0 NA
60 hsa-miR-18a-5p GNA11 2.3 0 -0.19 0.66767 MirTarget -0.13 0 NA
61 hsa-miR-18a-5p GNG7 2.3 0 0.32 0.39849 mirMAP -0.1 0.00016 NA
62 hsa-miR-18a-5p GNPDA2 2.3 0 -0.44 0.24754 MirTarget -0.14 0 NA
63 hsa-miR-18a-5p GTF2A1 2.3 0 -0.31 0.27739 MirTarget -0.21 0 NA
64 hsa-miR-18a-5p H6PD 2.3 0 -0.04 0.95545 mirMAP -0.13 0 NA
65 hsa-miR-18a-5p HERC1 2.3 0 -0.31 0.59955 miRNAWalker2 validate -0.17 0 NA
66 hsa-miR-18a-5p HIPK2 2.3 0 -0.04 0.95057 mirMAP -0.12 0 NA
67 hsa-miR-18a-5p HLF 2.3 0 0.19 0.61478 MirTarget -0.23 0 NA
68 hsa-miR-18a-5p HMBOX1 2.3 0 -0.24 0.30584 MirTarget; miRNATAP -0.21 0 NA
69 hsa-miR-18a-5p HOXA9 2.3 0 0.3 0.24005 miRNAWalker2 validate -0.19 0 NA
70 hsa-miR-18a-5p IGFBP5 2.3 0 -1.22 0.16438 mirMAP -0.23 0 NA
71 hsa-miR-18a-5p IL17B 2.3 0 0.05 0.89446 MirTarget -0.28 0 NA
72 hsa-miR-18a-5p ITGA2 2.3 0 -0.68 0.17493 MirTarget -0.28 0 NA
73 hsa-miR-18a-5p KCNA1 2.3 0 -0.29 0.40072 MirTarget; miRNATAP -0.37 0 NA
74 hsa-miR-18a-5p KIF13B 2.3 0 -1.26 0.0332 mirMAP -0.43 0 NA
75 hsa-miR-18a-5p LONP2 2.3 0 -0.57 0.32054 mirMAP -0.13 0 NA
76 hsa-miR-18a-5p LONRF2 2.3 0 -3.46 0 mirMAP -0.66 0 NA
77 hsa-miR-18a-5p LPP 2.3 0 0.06 0.88165 mirMAP -0.2 0 NA
78 hsa-miR-18a-5p LRP10 2.3 0 -0.64 0.37825 mirMAP -0.19 0 NA
79 hsa-miR-18a-5p MAN2B2 2.3 0 -0.81 0.16631 mirMAP -0.2 0 NA
80 hsa-miR-18a-5p MAP3K1 2.3 0 -1.01 0.07928 miRNATAP -0.32 0 NA
81 hsa-miR-18a-5p MDGA1 2.3 0 -0.83 0.00415 miRNATAP -0.2 0 NA
82 hsa-miR-18a-5p MEF2C 2.3 0 0.04 0.92239 MirTarget -0.13 0 NA
83 hsa-miR-18a-5p MEF2D 2.3 0 -0.48 0.43305 miRNATAP -0.13 0 NA
84 hsa-miR-18a-5p MPPED2 2.3 0 -0.69 0.00901 mirMAP -0.21 0 NA
85 hsa-miR-18a-5p MTHFR 2.3 0 -0.5 0.29916 mirMAP -0.17 0 NA
86 hsa-miR-18a-5p NBEA 2.3 0 -1.96 0 miRNAWalker2 validate -0.53 0 NA
87 hsa-miR-18a-5p NCOA1 2.3 0 -0.11 0.84877 MirTarget; miRNATAP -0.13 0 NA
88 hsa-miR-18a-5p NEDD4 2.3 0 -0.57 0.16492 MirTarget; miRNATAP -0.24 0 NA
89 hsa-miR-18a-5p NEDD9 2.3 0 -0.02 0.97525 miRTarBase; MirTarget; miRNATAP -0.2 0 22308110 NEDD9 and CDK19 were identified as novel miR-18a targets and were shown to be pro-proliferative genes with RNA interference of their transcripts decreasing proliferation in CRC cells
90 hsa-miR-18a-5p NHLRC2 2.3 0 -0.31 0.23645 mirMAP -0.16 0 NA
91 hsa-miR-18a-5p NR3C1 2.3 0 -0.04 0.93932 miRNAWalker2 validate; miRTarBase; miRNATAP -0.17 0 NA
92 hsa-miR-18a-5p NRG1 2.3 0 0.35 0.25963 miRNATAP -0.24 0 NA
93 hsa-miR-18a-5p NTRK3 2.3 0 0.65 0.06059 mirMAP -0.22 7.0E-5 NA
94 hsa-miR-18a-5p OLFML2A 2.3 0 -0.7 0.18468 mirMAP -0.2 0 NA
95 hsa-miR-18a-5p ORAI3 2.3 0 -0.92 0.04592 miRNAWalker2 validate; miRNATAP -0.18 0 NA
96 hsa-miR-18a-5p PAPPA 2.3 0 0 0.99641 miRNATAP -0.13 1.0E-5 NA
97 hsa-miR-18a-5p PARD6B 2.3 0 -1.86 2.0E-5 miRNAWalker2 validate; MirTarget -0.28 0 NA
98 hsa-miR-18a-5p PCBD2 2.3 0 -0.84 0.03148 mirMAP -0.15 0 NA
99 hsa-miR-18a-5p PCDHGA10 2.3 0 -1.03 0.00023 mirMAP -0.24 0 NA
100 hsa-miR-18a-5p PCDHGA12 2.3 0 -0.61 0.00802 mirMAP -0.23 0 NA
101 hsa-miR-18a-5p PCDHGA2 2.3 0 -0.37 0.16361 mirMAP -0.39 0 NA
102 hsa-miR-18a-5p PCDHGA3 2.3 0 -0.38 0.08606 mirMAP -0.31 0 NA
103 hsa-miR-18a-5p PCDHGA4 2.3 0 -0.49 0.04466 mirMAP -0.27 0 NA
104 hsa-miR-18a-5p PCDHGA5 2.3 0 -0.5 0.03567 mirMAP -0.33 0 NA
105 hsa-miR-18a-5p PCDHGA6 2.3 0 -0.31 0.13164 mirMAP -0.24 0 NA
106 hsa-miR-18a-5p PCDHGA7 2.3 0 -0.51 0.02544 mirMAP -0.25 0 NA
107 hsa-miR-18a-5p PCDHGA9 2.3 0 -0.93 7.0E-5 mirMAP -0.37 0 NA
108 hsa-miR-18a-5p PCDHGB2 2.3 0 0.02 0.94763 mirMAP -0.19 0 NA
109 hsa-miR-18a-5p PCDHGB3 2.3 0 0.46 0.06914 mirMAP -0.13 0.00065 NA
110 hsa-miR-18a-5p PCDHGB4 2.3 0 -0.26 0.34071 mirMAP -0.21 0 NA
111 hsa-miR-18a-5p PCDHGB6 2.3 0 -0.61 0.00833 mirMAP -0.31 0 NA
112 hsa-miR-18a-5p PCDHGB7 2.3 0 -0.93 0.00211 mirMAP -0.42 0 NA
113 hsa-miR-18a-5p PCDHGC5 2.3 0 0.24 0.39604 mirMAP -0.11 0.00411 NA
114 hsa-miR-18a-5p PDE4A 2.3 0 -0.75 0.08492 mirMAP -0.22 0 NA
115 hsa-miR-18a-5p PDE5A 2.3 0 -0.62 0.15406 MirTarget -0.24 0 NA
116 hsa-miR-18a-5p PHC3 2.3 0 -0.31 0.57488 MirTarget -0.14 0 NA
117 hsa-miR-18a-5p PRDM2 2.3 0 -0.23 0.67483 mirMAP -0.14 0 NA
118 hsa-miR-18a-5p PRICKLE2 2.3 0 -1.2 0.01176 MirTarget -0.39 0 NA
119 hsa-miR-18a-5p PRKACB 2.3 0 -0.26 0.62057 miRNATAP -0.11 0.00027 NA
120 hsa-miR-18a-5p PSD3 2.3 0 -1.08 0.03237 MirTarget; miRNATAP -0.33 0 NA
121 hsa-miR-18a-5p PTEN 2.3 0 -0.68 0.25726 miRNAWalker2 validate; miRTarBase -0.14 0 24681249; 27291152 However higher levels of the miR-17~92 cluster switched from PTEN to oncogenes including Ctnnb1 β-catenin via miR-18a which resulted in inhibition of tumor growth and metastasis;miR 18a promotes cell proliferation of esophageal squamous cell carcinoma cells by increasing cylin D1 via regulating PTEN PI3K AKT mTOR signaling axis
122 hsa-miR-18a-5p PTGR2 2.3 0 -0.78 0.04568 mirMAP -0.18 0 NA
123 hsa-miR-18a-5p RAB11FIP2 2.3 0 -0.2 0.62504 miRNATAP -0.13 0 NA
124 hsa-miR-18a-5p RASSF3 2.3 0 0.08 0.80781 miRNAWalker2 validate -0.12 5.0E-5 NA
125 hsa-miR-18a-5p REPS2 2.3 0 -1.71 0.00052 miRNATAP -0.34 0 NA
126 hsa-miR-18a-5p RIC3 2.3 0 0.2 0.52667 MirTarget -0.17 0.00105 NA
127 hsa-miR-18a-5p RICTOR 2.3 0 -0.38 0.42604 miRNAWalker2 validate -0.12 0 NA
128 hsa-miR-18a-5p RIMS4 2.3 0 -3.9 0 mirMAP -0.42 0 NA
129 hsa-miR-18a-5p RNF157 2.3 0 -0.98 0.00168 miRNAWalker2 validate -0.24 0 NA
130 hsa-miR-18a-5p ROBO2 2.3 0 -3.25 0 miRNATAP -0.51 0 NA
131 hsa-miR-18a-5p RORA 2.3 0 -0.12 0.74987 MirTarget; miRNATAP -0.16 0 NA
132 hsa-miR-18a-5p RPS6KA5 2.3 0 -0.82 0.01083 MirTarget -0.3 0 NA
133 hsa-miR-18a-5p RUNX1 2.3 0 -0.43 0.5297 miRNATAP -0.16 0 NA
134 hsa-miR-18a-5p SDC4 2.3 0 -0.29 0.70184 MirTarget -0.13 0 NA
135 hsa-miR-18a-5p SERTAD3 2.3 0 -0.66 0.19519 miRNAWalker2 validate -0.11 0 NA
136 hsa-miR-18a-5p SH3BP4 2.3 0 -0.91 0.14817 miRNATAP -0.26 0 NA
137 hsa-miR-18a-5p SH3RF1 2.3 0 -0.55 0.27787 miRNATAP -0.15 0 NA
138 hsa-miR-18a-5p SLC27A1 2.3 0 -0.53 0.307 mirMAP -0.17 0 NA
139 hsa-miR-18a-5p SLC35E2B 2.3 0 -0.59 0.3516 mirMAP -0.13 0 NA
140 hsa-miR-18a-5p SMAD3 2.3 0 -0.63 0.24535 miRNAWalker2 validate -0.15 0 23249750 The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling
141 hsa-miR-18a-5p SNED1 2.3 0 -1.19 0.00962 mirMAP -0.32 0 NA
142 hsa-miR-18a-5p SNURF 2.3 0 -1.28 0 MirTarget -0.35 0 NA
143 hsa-miR-18a-5p SNX33 2.3 0 -0.31 0.54589 mirMAP -0.11 0 NA
144 hsa-miR-18a-5p SORBS2 2.3 0 0.69 0.19769 MirTarget; miRNATAP -0.12 0.00074 NA
145 hsa-miR-18a-5p SSTR1 2.3 0 -1.42 0 mirMAP -0.53 0 NA
146 hsa-miR-18a-5p ST6GAL2 2.3 0 -1.17 0.00016 mirMAP -0.27 0 NA
147 hsa-miR-18a-5p STX1B 2.3 0 -0.71 0.00042 mirMAP -0.23 0 NA
148 hsa-miR-18a-5p SYT15 2.3 0 0.41 0.11089 MirTarget -0.11 0.00094 NA
149 hsa-miR-18a-5p SYT7 2.3 0 -0.61 0.2948 mirMAP -0.1 0.00032 NA
150 hsa-miR-18a-5p TAOK1 2.3 0 -0.58 0.13248 MirTarget; miRNATAP -0.24 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 HOMOPHILIC CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 16 153 6.195e-13 2.882e-09
2 CELL CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 17 204 4.699e-12 1.093e-08
3 BIOLOGICAL ADHESION 34 1032 4.076e-11 6.321e-08
4 CELL CELL ADHESION 23 608 6.461e-09 7.516e-06
5 RESPONSE TO HORMONE 26 893 1.258e-07 0.0001171
6 RESPONSE TO ENDOGENOUS STIMULUS 34 1450 2.188e-07 0.0001697
7 RESPONSE TO STEROID HORMONE 18 497 5.997e-07 0.0003987
8 RESPONSE TO ORGANIC CYCLIC COMPOUND 25 917 7.617e-07 0.000443
9 MAMMARY GLAND DEVELOPMENT 9 117 1.137e-06 0.0005879
10 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 26 1008 1.263e-06 0.0005879
11 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 26 1036 2.094e-06 0.000812
12 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 26 1036 2.094e-06 0.000812
13 NEUROGENESIS 31 1402 2.814e-06 0.001007
14 REGULATION OF SYSTEM PROCESS 17 507 3.541e-06 0.001105
15 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 27 1135 3.561e-06 0.001105
16 REGULATION OF MUSCLE TISSUE DEVELOPMENT 8 103 4.229e-06 0.00123
17 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 11 218 4.726e-06 0.001294
18 RESPONSE TO ESTRADIOL 9 146 7.116e-06 0.00184
19 POSITIVE REGULATION OF MOLECULAR FUNCTION 35 1791 9.197e-06 0.002252
20 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 31 1492 9.913e-06 0.002306
21 CELLULAR RESPONSE TO HORMONE STIMULUS 17 552 1.082e-05 0.002397
22 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 26 1142 1.197e-05 0.002532
23 POSITIVE REGULATION OF CATALYTIC ACTIVITY 31 1518 1.395e-05 0.002572
24 HORMONE MEDIATED SIGNALING PATHWAY 9 158 1.347e-05 0.002572
25 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 22 876 1.359e-05 0.002572
26 GLAND DEVELOPMENT 14 395 1.437e-05 0.002572
27 RESPONSE TO ABIOTIC STIMULUS 24 1024 1.677e-05 0.00289
28 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 15 465 2.134e-05 0.003546
29 REGULATION OF CELL DIFFERENTIATION 30 1492 2.63e-05 0.004079
30 RESPONSE TO ALCOHOL 13 362 2.556e-05 0.004079
31 LENS DEVELOPMENT IN CAMERA TYPE EYE 6 66 2.839e-05 0.004261
32 RESPONSE TO ESTROGEN 10 218 2.934e-05 0.004266
33 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 32 1672 3.595e-05 0.005069
34 REGULATION OF MUSCLE ORGAN DEVELOPMENT 7 103 4.076e-05 0.005578
35 MATING BEHAVIOR 4 23 4.915e-05 0.006181
36 REGULATION OF PHOSPHORUS METABOLIC PROCESS 31 1618 4.76e-05 0.006181
37 MULTI ORGANISM REPRODUCTIVE BEHAVIOR 4 23 4.915e-05 0.006181
38 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 28 1395 5.229e-05 0.006239
39 RESPONSE TO LIPID 21 888 5.186e-05 0.006239
40 REGULATION OF PROTEIN MODIFICATION PROCESS 32 1710 5.546e-05 0.006294
41 POSITIVE REGULATION OF CELL DIFFERENTIATION 20 823 5.442e-05 0.006294
42 REGULATION OF EPITHELIAL CELL PROLIFERATION 11 285 5.7e-05 0.006315
43 REGULATION OF POSITIVE CHEMOTAXIS 4 24 5.857e-05 0.006338
44 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 31 1656 7.342e-05 0.007142
45 STARTLE RESPONSE 4 25 6.924e-05 0.007142
46 REGULATION OF SYNAPSE ORGANIZATION 7 113 7.368e-05 0.007142
47 ORGAN MORPHOGENESIS 20 841 7.327e-05 0.007142
48 REGULATION OF CELLULAR COMPONENT MOVEMENT 19 771 7.023e-05 0.007142
49 REGULATION OF ADHERENS JUNCTION ORGANIZATION 5 50 8.524e-05 0.008064
50 HEART DEVELOPMENT 14 466 8.665e-05 0.008064
51 POSITIVE REGULATION OF MAPK CASCADE 14 470 9.483e-05 0.008171
52 CARDIOVASCULAR SYSTEM DEVELOPMENT 19 788 9.354e-05 0.008171
53 CIRCULATORY SYSTEM DEVELOPMENT 19 788 9.354e-05 0.008171
54 TISSUE DEVELOPMENT 29 1518 9.106e-05 0.008171
55 POSITIVE REGULATION OF CELL DEVELOPMENT 14 472 9.916e-05 0.008389
56 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 33 1848 0.0001032 0.008574
57 CEREBELLAR PURKINJE CELL LAYER FORMATION 3 11 0.0001122 0.008847
58 CEREBELLAR PURKINJE CELL DIFFERENTIATION 3 11 0.0001122 0.008847
59 RESPONSE TO OXYGEN CONTAINING COMPOUND 27 1381 0.0001121 0.008847
60 RESPONSE TO OXYGEN LEVELS 11 311 0.0001238 0.009444
61 NEURON DIFFERENTIATION 20 874 0.0001233 0.009444
62 REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 4 29 0.0001264 0.009486
63 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 22 1021 0.0001327 0.009797
NumGOOverlapSizeP ValueAdj. P Value
1 CALCIUM ION BINDING 23 697 7.951e-08 7.386e-05
2 KINASE BINDING 19 606 2.463e-06 0.001144
3 ENZYME BINDING 34 1737 1.224e-05 0.003791
4 TRANSCRIPTION FACTOR BINDING 16 524 2.204e-05 0.005118
5 ZINC ION BINDING 25 1155 4.137e-05 0.007687
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PART 29 1265 3.067e-06 0.001218
2 NEURON PROJECTION 24 942 4.173e-06 0.001218
3 CELL PROJECTION 34 1786 2.187e-05 0.004257

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Apelin_signaling_pathway_hsa04371 6 137 0.001519 0.04711
2 Hippo_signaling_pathway_hsa04390 6 154 0.002738 0.04711
3 p53_signaling_pathway_hsa04115 4 68 0.003301 0.04711
4 cGMP_PKG_signaling_pathway_hsa04022 6 163 0.003623 0.04711
5 MAPK_signaling_pathway_hsa04010 8 295 0.005367 0.05581
6 Endocytosis_hsa04144 7 244 0.00671 0.05816
7 Hedgehog_signaling_pathway_hsa04340 3 47 0.008696 0.05957
8 cAMP_signaling_pathway_hsa04024 6 198 0.009165 0.05957
9 Wnt_signaling_pathway_hsa04310 5 146 0.0104 0.06011
10 Cellular_senescence_hsa04218 5 160 0.01498 0.07788
11 Tight_junction_hsa04530 5 170 0.01896 0.08965
12 Calcium_signaling_pathway_hsa04020 5 182 0.0246 0.1066
13 FoxO_signaling_pathway_hsa04068 4 132 0.03153 0.1261
14 ECM_receptor_interaction_hsa04512 3 82 0.03785 0.1346
15 TGF_beta_signaling_pathway_hsa04350 3 84 0.0402 0.1346
16 ErbB_signaling_pathway_hsa04012 3 85 0.0414 0.1346
17 Focal_adhesion_hsa04510 4 199 0.1054 0.3084
18 Neuroactive_ligand_receptor_interaction_hsa04080 5 278 0.1068 0.3084
19 Rap1_signaling_pathway_hsa04015 4 206 0.1157 0.3166
20 Adherens_junction_hsa04520 2 72 0.1372 0.3567
21 Ras_signaling_pathway_hsa04014 4 232 0.1573 0.3895
22 Gap_junction_hsa04540 2 88 0.1878 0.4439
23 NF_kappa_B_signaling_pathway_hsa04064 2 95 0.2107 0.4587
24 PI3K_Akt_signaling_pathway_hsa04151 5 352 0.2117 0.4587
25 TNF_signaling_pathway_hsa04668 2 108 0.2539 0.528
26 Cell_cycle_hsa04110 2 124 0.3071 0.5915
27 Oocyte_meiosis_hsa04114 2 124 0.3071 0.5915
28 Autophagy_animal_hsa04140 2 128 0.3204 0.595
29 Cell_adhesion_molecules_.CAMs._hsa04514 2 145 0.3758 0.6678
30 mTOR_signaling_pathway_hsa04150 2 151 0.395 0.6678
31 Phagosome_hsa04145 2 152 0.3981 0.6678
32 Necroptosis_hsa04217 2 164 0.4355 0.7077
33 Regulation_of_actin_cytoskeleton_hsa04810 2 208 0.5607 0.8835
34 Cytokine_cytokine_receptor_interaction_hsa04060 2 270 0.7015 0.9311

Quest ID: 3a268e5fbf28af6ab371dcd46528bb5e