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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-141-3p ABL1 0.73 0.00012 0.08 0.3604 MirTarget -0.2 0 NA
2 hsa-miR-149-5p ABL1 0.44 0.0642 0.08 0.3604 miRNAWalker2 validate -0.12 0 NA
3 hsa-miR-19a-3p ABL1 1.36 0 0.08 0.3604 mirMAP -0.17 0 NA
4 hsa-miR-200a-3p ABL1 0.61 0.0029 0.08 0.3604 MirTarget -0.17 0 NA
5 hsa-miR-203a-3p ABL1 0.04 0.88046 0.08 0.3604 miRTarBase -0.11 0 21454413 Treatment of lymphoma B cells with demethylating agents led to increased miR-203 expression and the concomitant downregulation of ABL1 confirming the epigenetic regulation of this miRNA; In summary our results show that the transformation from gastritis to MALT lymphoma is epigenetically regulated by miR-203 promoter methylation and identify ABL1 as a novel target for the treatment of this malignancy
6 hsa-miR-29a-5p ABL1 0.32 0.03704 0.08 0.3604 MirTarget -0.1 7.0E-5 NA
7 hsa-miR-29b-3p ABL1 -0.11 0.51126 0.08 0.3604 miRNATAP -0.15 0 NA
8 hsa-miR-30b-5p ABL1 -0.4 0.00347 0.08 0.3604 MirTarget; miRNATAP -0.17 0 NA
9 hsa-miR-30c-5p ABL1 0.02 0.88637 0.08 0.3604 MirTarget; miRNATAP -0.19 0 NA
10 hsa-miR-193a-3p ANAPC1 0.22 0.11183 0.11 0.29388 miRanda -0.12 0.00016 NA
11 hsa-miR-26b-5p ANAPC1 -0.25 0.02852 0.11 0.29388 miRNAWalker2 validate -0.19 0 NA
12 hsa-miR-100-5p ANAPC11 -1.86 0 0.23 0.03985 miRNAWalker2 validate -0.1 5.0E-5 NA
13 hsa-miR-542-3p ANAPC7 0.64 0 -0.08 0.21953 miRanda -0.1 0 NA
14 hsa-miR-18a-5p ATM 1.65 0 -0.09 0.45414 miRNAWalker2 validate; miRTarBase; MirTarget -0.17 0 23437304; 25963391; 23857602; 23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases
15 hsa-miR-19b-3p ATM 0.54 0.00062 -0.09 0.45414 miRNAWalker2 validate -0.19 0 NA
16 hsa-miR-203a-3p ATM 0.04 0.88046 -0.09 0.45414 MirTarget -0.1 0 24145123; 27542403 miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression
17 hsa-miR-21-5p ATM 1.62 0 -0.09 0.45414 mirMAP -0.14 0.00355 26289851 MiR-21 is an oncomiR that is overexpressed in nearly all cancers including ATC; Hence suppression of miR-21 could pave the way for ATC therapy
18 hsa-miR-30c-5p ATM 0.02 0.88637 -0.09 0.45414 mirMAP -0.12 0.00081 NA
19 hsa-miR-339-5p ATM 1.08 0 -0.09 0.45414 miRanda -0.14 0 NA
20 hsa-miR-455-5p ATM 1.41 0 -0.09 0.45414 miRanda -0.22 0 NA
21 hsa-miR-500a-5p ATM 0.68 8.0E-5 -0.09 0.45414 mirMAP -0.14 1.0E-5 NA
22 hsa-miR-576-5p ATM 0.94 0 -0.09 0.45414 mirMAP -0.17 2.0E-5 NA
23 hsa-miR-590-5p ATM 0.76 0 -0.09 0.45414 mirMAP -0.15 0.00038 NA
24 hsa-miR-30b-5p ATR -0.4 0.00347 0.34 0.00089 mirMAP -0.11 0.00089 NA
25 hsa-miR-139-5p BUB1 -1.46 0 1.79 0 miRanda -0.29 0 NA
26 hsa-miR-199a-5p BUB1 -0.36 0.04351 1.79 0 miRanda -0.19 0 NA
27 hsa-miR-199b-5p BUB1 -1.08 0 1.79 0 miRanda -0.23 0 NA
28 hsa-miR-495-3p BUB1 -1.48 0 1.79 0 MirTarget -0.2 0 NA
29 hsa-miR-653-5p BUB1 -1.05 0 1.79 0 MirTarget -0.2 0 NA
30 hsa-miR-22-3p BUB1B 0.01 0.92636 1.71 0 miRNAWalker2 validate -0.28 0.0008 NA
31 hsa-miR-486-5p BUB1B -1.7 0 1.71 0 miRanda -0.11 0.00012 NA
32 hsa-miR-107 CCNA1 -0.04 0.67162 1.54 0.00197 miRanda -0.68 0.00113 NA
33 hsa-miR-30a-5p CCNA1 -1.8 0 1.54 0.00197 MirTarget -0.48 9.0E-5 NA
34 hsa-miR-30b-5p CCNA1 -0.4 0.00347 1.54 0.00197 MirTarget -0.5 0.00164 NA
35 hsa-miR-30c-5p CCNA1 0.02 0.88637 1.54 0.00197 MirTarget -0.44 0.00251 NA
36 hsa-miR-30d-5p CCNA1 -0.38 0.00017 1.54 0.00197 MirTarget -1.15 0 NA
37 hsa-miR-30e-5p CCNA1 -1.02 0 1.54 0.00197 MirTarget -1.32 0 NA
38 hsa-miR-320b CCNA1 1.23 0 1.54 0.00197 miRanda -0.45 0.00063 NA
39 hsa-miR-199a-5p CCNA2 -0.36 0.04351 1.57 0 miRanda -0.21 0 NA
40 hsa-miR-199b-5p CCNA2 -1.08 0 1.57 0 miRanda -0.23 0 NA
41 hsa-miR-218-5p CCNA2 -1.07 0 1.57 0 MirTarget -0.14 6.0E-5 NA
42 hsa-miR-299-5p CCNA2 -1.92 0 1.57 0 miRNATAP -0.24 0 NA
43 hsa-miR-29a-3p CCNA2 -1.27 0 1.57 0 MirTarget -0.12 0.00994 NA
44 hsa-miR-29c-3p CCNA2 -2.08 0 1.57 0 MirTarget -0.12 0.00012 NA
45 hsa-miR-139-5p CCNB1 -1.46 0 1.45 0 miRanda -0.2 0 NA
46 hsa-let-7a-5p CCNB2 -0.44 3.0E-5 1.83 0 miRNAWalker2 validate -0.17 0.00604 NA
47 hsa-let-7c-5p CCNB2 -2.08 0 1.83 0 miRNAWalker2 validate -0.2 0 NA
48 hsa-let-7g-5p CCND1 -0.25 0.0094 -0.01 0.95947 miRNATAP -0.42 1.0E-5 NA
49 hsa-miR-106a-5p CCND1 0.68 0.00222 -0.01 0.95947 MirTarget; miRNATAP -0.29 0 NA
50 hsa-miR-1266-5p CCND1 -0.6 0.02013 -0.01 0.95947 MirTarget -0.14 0.00019 NA
51 hsa-miR-142-3p CCND1 1.13 0 -0.01 0.95947 miRanda -0.21 0 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil
52 hsa-miR-142-5p CCND1 0.29 0.09 -0.01 0.95947 PITA -0.19 0.00053 NA
53 hsa-miR-150-5p CCND1 -0.24 0.33155 -0.01 0.95947 mirMAP -0.18 0 NA
54 hsa-miR-155-5p CCND1 0.53 0.00249 -0.01 0.95947 miRNAWalker2 validate -0.21 0.0001 26955820 MicroRNA 155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastric cancer cell growth by targeting cyclin D1
55 hsa-miR-15a-5p CCND1 0.78 0 -0.01 0.95947 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.32 5.0E-5 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR
56 hsa-miR-15b-5p CCND1 0.85 0 -0.01 0.95947 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.2 0.00913 NA
57 hsa-miR-16-1-3p CCND1 0.96 0 -0.01 0.95947 miRNAWalker2 validate; miRTarBase -0.3 0 22922827; 18483394 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL
58 hsa-miR-16-5p CCND1 0.52 0 -0.01 0.95947 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.36 3.0E-5 23991964; 22922827; 18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL
59 hsa-miR-19a-3p CCND1 1.36 0 -0.01 0.95947 miRNAWalker2 validate; miRTarBase; miRNATAP -0.13 0.00806 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression
60 hsa-miR-19b-1-5p CCND1 0.76 0 -0.01 0.95947 miRNAWalker2 validate; miRTarBase -0.2 0.00133 NA
61 hsa-miR-19b-3p CCND1 0.54 0.00062 -0.01 0.95947 miRNATAP -0.23 0.0001 NA
62 hsa-miR-20a-5p CCND1 1.15 0 -0.01 0.95947 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.15 0.0057 NA
63 hsa-miR-20b-5p CCND1 0.35 0.23201 -0.01 0.95947 MirTarget; miRNATAP -0.25 0 NA
64 hsa-miR-29b-3p CCND1 -0.11 0.51126 -0.01 0.95947 mirMAP -0.18 0.00109 NA
65 hsa-miR-29c-3p CCND1 -2.08 0 -0.01 0.95947 mirMAP -0.16 0.00015 NA
66 hsa-miR-33a-3p CCND1 0.2 0.21234 -0.01 0.95947 MirTarget -0.2 0.00047 NA
67 hsa-miR-34a-5p CCND1 -0.12 0.364 -0.01 0.95947 miRNAWalker2 validate; miRTarBase; miRNATAP -0.31 2.0E-5 25792709; 21399894 This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a
68 hsa-miR-425-5p CCND1 0.93 0 -0.01 0.95947 miRNAWalker2 validate -0.15 0.00573 NA
69 hsa-miR-497-5p CCND1 -0.97 0 -0.01 0.95947 MirTarget; miRNATAP -0.27 5.0E-5 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer
70 hsa-miR-590-3p CCND1 0.22 0.09659 -0.01 0.95947 mirMAP -0.24 0.00077 NA
71 hsa-miR-7-1-3p CCND1 1.14 0 -0.01 0.95947 mirMAP -0.22 0.00036 NA
72 hsa-miR-9-5p CCND1 1.66 2.0E-5 -0.01 0.95947 miRNAWalker2 validate -0.14 0 NA
73 hsa-miR-92a-3p CCND1 0.99 0 -0.01 0.95947 miRNAWalker2 validate -0.24 0.002 NA
74 hsa-miR-942-5p CCND1 0.68 0 -0.01 0.95947 MirTarget -0.23 0.00111 NA
75 hsa-miR-224-3p CCND2 0.5 0.00811 0.15 0.53242 mirMAP -0.31 0 NA
76 hsa-miR-27b-3p CCND3 -0.73 0 -0.05 0.63156 miRNAWalker2 validate -0.13 0.00016 NA
77 hsa-miR-125b-5p CCNE1 -0.99 0 1.47 0 miRNAWalker2 validate -0.28 0 NA
78 hsa-miR-151a-3p CCNE1 0.13 0.29527 1.47 0 miRNAWalker2 validate -0.15 0.00299 NA
79 hsa-miR-195-5p CCNE1 -1.84 0 1.47 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.31 0 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively
80 hsa-miR-215-5p CCNE1 -0.76 6.0E-5 1.47 0 miRNAWalker2 validate -0.13 0.0001 NA
81 hsa-miR-26a-5p CCNE1 -1.09 0 1.47 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.49 0 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen
82 hsa-miR-497-5p CCNE1 -0.97 0 1.47 0 MirTarget; miRNATAP -0.16 0.00018 24112607; 25909221; 24909281 Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells;miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1
83 hsa-miR-30a-5p CCNE2 -1.8 0 1.24 0 miRNATAP -0.16 5.0E-5 NA
84 hsa-miR-369-3p CCNE2 -1.23 0 1.24 0 PITA -0.24 0 NA
85 hsa-miR-23a-3p CCNH 0.35 6.0E-5 -0.25 0.00055 MirTarget -0.14 9.0E-5 NA
86 hsa-let-7a-3p CDC14A 0.1 0.42376 -0.49 0.00362 mirMAP -0.23 0.00018 NA
87 hsa-miR-324-5p CDC14A 1.67 0 -0.49 0.00362 miRanda -0.15 0.00028 NA
88 hsa-miR-338-3p CDC14A -0.95 0 -0.49 0.00362 miRanda -0.13 0.00159 NA
89 hsa-miR-342-3p CDC14A 1 0 -0.49 0.00362 miRanda -0.17 0.00019 NA
90 hsa-miR-424-5p CDC14A 1.48 0 -0.49 0.00362 miRNAWalker2 validate; miRTarBase -0.17 5.0E-5 NA
91 hsa-miR-503-5p CDC14A 2.85 0 -0.49 0.00362 miRNAWalker2 validate; miRTarBase -0.18 0 NA
92 hsa-miR-576-5p CDC14A 0.94 0 -0.49 0.00362 mirMAP -0.25 0 NA
93 hsa-miR-944 CDC14A 1.47 0 -0.49 0.00362 mirMAP -0.1 0.00355 NA
94 hsa-let-7a-3p CDC14B 0.1 0.42376 -0.23 0.09822 miRNATAP -0.18 0.00028 NA
95 hsa-miR-146b-3p CDC14B 0.19 0.16914 -0.23 0.09822 miRNATAP -0.13 0.00308 NA
96 hsa-miR-424-5p CDC14B 1.48 0 -0.23 0.09822 MirTarget -0.14 7.0E-5 NA
97 hsa-miR-450b-5p CDC14B 1.26 0 -0.23 0.09822 MirTarget; miRNATAP -0.11 0.00282 NA
98 hsa-miR-542-3p CDC14B 0.64 0 -0.23 0.09822 miRanda -0.16 0.00057 NA
99 hsa-miR-576-5p CDC14B 0.94 0 -0.23 0.09822 mirMAP -0.15 0.00038 NA
100 hsa-miR-107 CDC16 -0.04 0.67162 -0 0.96792 miRanda -0.2 0 NA
101 hsa-miR-23b-3p CDC20 -0.5 3.0E-5 1.92 0 miRNAWalker2 validate -0.26 1.0E-5 NA
102 hsa-miR-30a-5p CDC20 -1.8 0 1.92 0 miRNAWalker2 validate -0.27 0 NA
103 hsa-miR-125a-5p CDC23 0.22 0.11955 0.25 0.00092 miRanda -0.1 1.0E-5 NA
104 hsa-let-7e-5p CDC25A 0.09 0.51287 0.86 0 MirTarget; miRNATAP -0.17 0.00016 NA
105 hsa-miR-195-5p CDC25A -1.84 0 0.86 0 MirTarget; miRNATAP -0.14 8.0E-5 NA
106 hsa-miR-337-3p CDC25A -1.7 0 0.86 0 mirMAP -0.19 0 NA
107 hsa-let-7a-5p CDC25B -0.44 3.0E-5 1.62 0 miRNAWalker2 validate -0.2 0.0017 NA
108 hsa-miR-148a-3p CDC25B -0.43 0.00954 1.62 0 miRNAWalker2 validate; miRNATAP -0.21 0 25341915 Gene CDC25B might be the target gene of miR-148a according to the results of targetscan; CDC25B may be the target gene of miR-148a that plays a role in tumor suppressor
109 hsa-miR-27b-3p CDC25B -0.73 0 1.62 0 miRNATAP -0.23 3.0E-5 NA
110 hsa-miR-15a-5p CDC27 0.78 0 0.35 0 miRNATAP -0.1 3.0E-5 NA
111 hsa-miR-497-5p CDC27 -0.97 0 0.35 0 miRNATAP -0.11 0 NA
112 hsa-miR-199a-5p CDC6 -0.36 0.04351 1.92 0 miRanda -0.17 0 NA
113 hsa-miR-199b-5p CDC6 -1.08 0 1.92 0 miRanda -0.23 0 NA
114 hsa-miR-26a-5p CDC6 -1.09 0 1.92 0 miRNAWalker2 validate -0.33 0 25100863; 27158389 Here it is demonstrated that miR26a and miR26b inhibit replication licensing and the proliferation migration and invasion of lung cancer cells by targeting CDC6; The current study suggests that miR26a miR26b and CDC6 and factors regulating their expression represent potential cancer diagnostic and prognostic markers as well as anticancer targets;miR 26a inhibits the proliferation of ovarian cancer cells via regulating CDC6 expression; Bioinformatics analysis revealed Cdc6 was a target gene of miR-26a; dual-luciferase assay and validation assay showed miR-26a could act on the 3'UTR of Cdc6 to regulate Cdc6 expression; These findings suggest that miR-26a may act on the 3'UTR of Cdc6 to regulate Cdc6 expression which then inhibit the proliferation of ovarian cancer cells and induce their apoptosis
115 hsa-miR-199a-5p CDC7 -0.36 0.04351 1.03 0 MirTarget; miRanda -0.17 0 NA
116 hsa-miR-199b-5p CDC7 -1.08 0 1.03 0 MirTarget; miRanda -0.16 0 NA
117 hsa-miR-369-3p CDC7 -1.23 0 1.03 0 mirMAP -0.15 0 NA
118 hsa-miR-10b-5p CDK2 -0.58 0 0.83 0 miRNAWalker2 validate -0.16 0 NA
119 hsa-miR-495-3p CDK2 -1.48 0 0.83 0 mirMAP -0.12 0 NA
120 hsa-miR-101-3p CDK6 -1.91 0 0.94 0 mirMAP -0.33 0 NA
121 hsa-miR-106a-5p CDK6 0.68 0.00222 0.94 0 mirMAP -0.27 0 NA
122 hsa-miR-140-3p CDK6 -0.97 0 0.94 0 miRNATAP -0.27 0.00057 NA
123 hsa-miR-141-3p CDK6 0.73 0.00012 0.94 0 TargetScan; miRNATAP -0.14 0.00069 NA
124 hsa-miR-142-5p CDK6 0.29 0.09 0.94 0 PITA -0.14 0.00345 NA
125 hsa-miR-146a-5p CDK6 -0.02 0.90588 0.94 0 mirMAP -0.22 1.0E-5 NA
126 hsa-miR-148a-3p CDK6 -0.43 0.00954 0.94 0 mirMAP -0.35 0 NA
127 hsa-miR-148a-5p CDK6 -1 0 0.94 0 mirMAP -0.17 6.0E-5 NA
128 hsa-miR-15a-5p CDK6 0.78 0 0.94 0 miRNATAP -0.29 3.0E-5 NA
129 hsa-miR-16-1-3p CDK6 0.96 0 0.94 0 mirMAP -0.19 0.00047 NA
130 hsa-miR-16-5p CDK6 0.52 0 0.94 0 miRNAWalker2 validate; miRTarBase -0.39 0 NA
131 hsa-miR-191-5p CDK6 0.65 0 0.94 0 miRNAWalker2 validate; miRTarBase -0.3 0 NA
132 hsa-miR-195-5p CDK6 -1.84 0 0.94 0 miRNAWalker2 validate; miRTarBase -0.15 0.00222 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively
133 hsa-miR-200a-3p CDK6 0.61 0.0029 0.94 0 miRNATAP -0.14 0.00037 24009066 microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6
134 hsa-miR-200b-3p CDK6 0.07 0.68286 0.94 0 mirMAP -0.17 0.0002 NA
135 hsa-miR-20b-5p CDK6 0.35 0.23201 0.94 0 mirMAP -0.32 0 26166554 The transfection of miR-20b into EJ cells induced G1 phase cell cycle arrest via the decreased expression of cyclin D1 CDK2 and CDK6 without affecting another G1 phase cell cycle regulator cyclin E
136 hsa-miR-217 CDK6 -1.35 0 0.94 0 mirMAP -0.1 0.00385 NA
137 hsa-miR-218-5p CDK6 -1.07 0 0.94 0 miRNAWalker2 validate -0.16 0.00036 23996750 Ectopic expression of miR-218 in HepG2 cells resulted in suppressed cell proliferation and enhanced cell apoptosis as well as the down-regulation of Bmi-1 and CDK6 mRNA and protein expressions P<0.05; The low-expression of miR-218 is correlated with malignant clinicopathological characteristics of HCC and miR-218 may inhibit cell proliferation and promote cell apoptosis by down-regulating Bmi-1 and CDK6 in HCC
138 hsa-miR-23b-3p CDK6 -0.5 3.0E-5 0.94 0 mirMAP -0.19 0.00569 NA
139 hsa-miR-26a-5p CDK6 -1.09 0 0.94 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.3 2.0E-5 26314438 Maxvision immunohistochemistry technique was used to detect the expression level of CDK6 and miR-26a in tissue of 20 ENKTCL cases 10 cases of proliferative lymphadenitis and 10 samples of normal lymph node respectively; The possible role of miR-26a and its target gene CDK6 in genesis and development of ENKTCL were analyzed according to the clinical features of ENKTCL patients; Correlation analysis showed that there was significant negative correlation between miR-26a expression and CDK6 expression r = -0.54 P = 0.04
140 hsa-miR-26b-5p CDK6 -0.25 0.02852 0.94 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.37 0 NA
141 hsa-miR-27b-3p CDK6 -0.73 0 0.94 0 mirMAP -0.25 0.0001 NA
142 hsa-miR-27b-5p CDK6 0.58 0.00018 0.94 0 mirMAP -0.14 0.00915 NA
143 hsa-miR-29b-3p CDK6 -0.11 0.51126 0.94 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.23 0 23245396; 25472644; 26180082; 23591808; 27230400; 20086245 The IFN-γ-induced G1-arrest of melanoma cells involves down-regulation of CDK6 which we proved to be a direct target of miR-29 in these cells;Moreover miR-29b inhibited the expression of MCL1 and CDK6;Knockdown of NTSR1 increased the expression of miR-29b-1 and miR-129-3p which were responsible for the decreased CDK6 expression;Here we have identified the oncogene cyclin-dependent protein kinase 6 CDK6 as a direct target of miR-29b in lung cancer;MiR 29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6; In this study we investigated the role of miR-29b as a novel regulator of CDK6 using bioinformatics methods; We demonstrated that CDK6 can be downregulated by miR-29b via binding to the 3'-UTR region in osteosarcoma cells; Furthermore we identified an inverse correlation between miR-29b and CDK6 protein levels in osteosarcoma tissues; The results revealed that miR-29b acts as a tumor suppressor of osteosarcoma by targeting CDK6 in the proliferation and migration processes;microRNA expression profile and identification of miR 29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma; Furthermore we demonstrate miR-29 inhibition of CDK6 protein and mRNA levels by direct binding to 3'-untranslated region; Inverse correlation between miR-29 and CDK6 was observed in MCL
144 hsa-miR-29c-3p CDK6 -2.08 0 0.94 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.26 0 26396669 Furthermore through qPCR and Western blot assays confirmed that overexpression of miR-29c reduced CDK6 mRNA and protein levels; miR-29c could inhibit the proliferation migration and invasion of bladder cancer cells via regulating CDK6
145 hsa-miR-30a-3p CDK6 -2.26 0 0.94 0 miRNAWalker2 validate; miRTarBase; mirMAP -0.14 0.00032 NA
146 hsa-miR-30a-5p CDK6 -1.8 0 0.94 0 mirMAP -0.24 0 NA
147 hsa-miR-30b-5p CDK6 -0.4 0.00347 0.94 0 mirMAP -0.43 0 NA
148 hsa-miR-30c-5p CDK6 0.02 0.88637 0.94 0 mirMAP -0.34 0 NA
149 hsa-miR-30d-3p CDK6 -0.58 0 0.94 0 mirMAP -0.5 0 NA
150 hsa-miR-30d-5p CDK6 -0.38 0.00017 0.94 0 mirMAP -0.48 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 CELL CYCLE 76 1316 1.863e-77 8.667e-74
2 CELL CYCLE PROCESS 72 1081 3.725e-76 8.667e-73
3 MITOTIC CELL CYCLE 65 766 2.121e-73 3.29e-70
4 REGULATION OF CELL CYCLE 68 949 1.165e-72 1.355e-69
5 REGULATION OF MITOTIC CELL CYCLE 47 468 1.985e-53 1.847e-50
6 REGULATION OF CELL CYCLE PHASE TRANSITION 40 321 1.284e-48 9.96e-46
7 REGULATION OF CELL CYCLE PROCESS 46 558 4.052e-48 2.693e-45
8 CELL CYCLE PHASE TRANSITION 37 255 2.677e-47 1.557e-44
9 NEGATIVE REGULATION OF CELL CYCLE 42 433 1.618e-46 8.368e-44
10 CELL CYCLE CHECKPOINT 33 194 2.285e-44 1.063e-41
11 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 32 199 3.931e-42 1.663e-39
12 NEGATIVE REGULATION OF CELL CYCLE PROCESS 32 214 4.69e-41 1.819e-38
13 MITOTIC CELL CYCLE CHECKPOINT 28 139 1.096e-39 3.922e-37
14 CELL DIVISION 37 460 1.695e-37 5.632e-35
15 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 26 146 2.712e-35 8.413e-33
16 REGULATION OF TRANSFERASE ACTIVITY 44 946 6.733e-35 1.958e-32
17 POSITIVE REGULATION OF CELL CYCLE 32 332 1.054e-34 2.885e-32
18 REGULATION OF PROTEIN MODIFICATION PROCESS 52 1710 4.089e-33 1.057e-30
19 CELL CYCLE G1 S PHASE TRANSITION 23 111 7.58e-33 1.763e-30
20 G1 S TRANSITION OF MITOTIC CELL CYCLE 23 111 7.58e-33 1.763e-30
21 DNA INTEGRITY CHECKPOINT 24 146 1.162e-31 2.575e-29
22 POSITIVE REGULATION OF CELL CYCLE PROCESS 27 247 1.216e-30 2.571e-28
23 MITOTIC NUCLEAR DIVISION 30 361 1.704e-30 3.447e-28
24 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 20 98 1.912e-28 3.707e-26
25 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 22 147 4.512e-28 8.397e-26
26 ORGANELLE FISSION 31 496 1.006e-27 1.801e-25
27 G1 DNA DAMAGE CHECKPOINT 18 73 2.726e-27 4.68e-25
28 REGULATION OF ORGANELLE ORGANIZATION 41 1178 2.816e-27 4.68e-25
29 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 19 96 9.088e-27 1.458e-24
30 MITOTIC DNA INTEGRITY CHECKPOINT 19 100 2.114e-26 3.278e-24
31 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 33 720 2.886e-25 4.332e-23
32 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 38 1087 3.924e-25 5.706e-23
33 REGULATION OF CELL DIVISION 24 272 6.246e-25 8.807e-23
34 POSITIVE REGULATION OF CELL CYCLE ARREST 17 85 4.256e-24 5.824e-22
35 REGULATION OF CELL CYCLE ARREST 18 108 6.143e-24 8.166e-22
36 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 30 616 1.264e-23 1.634e-21
37 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 40 1492 2.664e-22 3.35e-20
38 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 24 351 2.824e-22 3.446e-20
39 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 36 1135 2.888e-22 3.446e-20
40 REGULATION OF NUCLEAR DIVISION 19 163 3.852e-22 4.48e-20
41 REGULATION OF PHOSPHORUS METABOLIC PROCESS 41 1618 5.183e-22 5.882e-20
42 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 28 616 3.383e-21 3.748e-19
43 SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 17 127 6.168e-21 6.674e-19
44 REGULATION OF CHROMOSOME ORGANIZATION 21 278 2.04e-20 2.158e-18
45 CELL CYCLE G2 M PHASE TRANSITION 17 138 2.678e-20 2.769e-18
46 REGULATION OF SISTER CHROMATID SEGREGATION 14 67 2.8e-20 2.832e-18
47 REGULATION OF KINASE ACTIVITY 29 776 1.233e-19 1.22e-17
48 CHROMOSOME ORGANIZATION 32 1009 1.261e-19 1.222e-17
49 REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 15 97 1.486e-19 1.411e-17
50 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 29 829 7.407e-19 6.893e-17
51 REGULATION OF CHROMOSOME SEGREGATION 14 85 1.021e-18 9.318e-17
52 CELLULAR RESPONSE TO STRESS 37 1565 1.291e-18 1.156e-16
53 REGULATION OF PROTEIN CATABOLIC PROCESS 22 393 1.468e-18 1.289e-16
54 POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 11 36 3.44e-18 2.964e-16
55 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 21 360 4.263e-18 3.543e-16
56 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 23 470 4.264e-18 3.543e-16
57 CELL CYCLE ARREST 16 154 6.204e-18 5.065e-16
58 POSITIVE REGULATION OF CELL DEATH 25 605 6.485e-18 5.202e-16
59 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 19 274 8.095e-18 6.384e-16
60 DNA METABOLIC PROCESS 27 758 1.003e-17 7.78e-16
61 ANAPHASE PROMOTING COMPLEX DEPENDENT CATABOLIC PROCESS 13 77 1.346e-17 1.027e-15
62 REGULATION OF LIGASE ACTIVITY 15 130 1.45e-17 1.088e-15
63 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 24 573 2.476e-17 1.8e-15
64 REGULATION OF PROTEOLYSIS 26 711 2.446e-17 1.8e-15
65 REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 10 29 3.001e-17 2.116e-15
66 POSITIVE REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 10 29 3.001e-17 2.116e-15
67 REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 11 43 3.213e-17 2.231e-15
68 NEGATIVE REGULATION OF MOLECULAR FUNCTION 30 1079 8.958e-17 6.041e-15
69 POSITIVE REGULATION OF PROTEOLYSIS 20 363 8.931e-17 6.041e-15
70 REGULATION OF CELLULAR PROTEIN LOCALIZATION 23 552 1.44e-16 9.573e-15
71 CHROMOSOME SEGREGATION 18 272 1.487e-16 9.747e-15
72 NUCLEAR CHROMOSOME SEGREGATION 17 228 1.525e-16 9.853e-15
73 REGULATION OF CELL PROLIFERATION 34 1496 1.845e-16 1.176e-14
74 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 16 192 2.189e-16 1.376e-14
75 POSITIVE REGULATION OF MITOTIC CELL CYCLE 14 123 2.273e-16 1.41e-14
76 POSITIVE REGULATION OF CATALYTIC ACTIVITY 34 1518 2.864e-16 1.753e-14
77 REGULATION OF CATABOLIC PROCESS 25 731 5.408e-16 3.268e-14
78 SISTER CHROMATID SEGREGATION 15 176 1.459e-15 8.702e-14
79 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 17 263 1.668e-15 9.822e-14
80 POSITIVE REGULATION OF LIGASE ACTIVITY 13 110 1.731e-15 1.007e-13
81 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 19 370 2.096e-15 1.204e-13
82 POSITIVE REGULATION OF MOLECULAR FUNCTION 35 1791 5.719e-15 3.245e-13
83 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 35 1805 7.239e-15 4.058e-13
84 REGULATION OF MEMBRANE PERMEABILITY 11 70 1.098e-14 6.085e-13
85 POSITIVE REGULATION OF GENE EXPRESSION 34 1733 1.472e-14 8.059e-13
86 DNA REPLICATION 15 208 1.763e-14 9.54e-13
87 PROTEIN PHOSPHORYLATION 26 944 2.115e-14 1.131e-12
88 PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 13 134 2.373e-14 1.255e-12
89 REGULATION OF PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 12 103 2.675e-14 1.398e-12
90 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 28 1152 3.678e-14 1.902e-12
91 REGULATION OF CELL DEATH 31 1472 4.993e-14 2.537e-12
92 PROTEASOMAL PROTEIN CATABOLIC PROCESS 16 271 5.016e-14 2.537e-12
93 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 20 514 6.675e-14 3.339e-12
94 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 16 280 8.326e-14 4.121e-12
95 RESPONSE TO ABIOTIC STIMULUS 26 1024 1.404e-13 6.874e-12
96 POSITIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 14 196 1.609e-13 7.801e-12
97 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 20 541 1.732e-13 8.222e-12
98 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 20 541 1.732e-13 8.222e-12
99 MITOCHONDRIAL MEMBRANE ORGANIZATION 11 92 2.524e-13 1.186e-11
100 CELLULAR RESPONSE TO UV 10 66 2.772e-13 1.29e-11
101 INTRACELLULAR SIGNAL TRANSDUCTION 31 1572 2.905e-13 1.338e-11
102 NEGATIVE REGULATION OF CHROMOSOME SEGREGATION 8 28 2.934e-13 1.339e-11
103 POSITIVE REGULATION OF CELL CYCLE PHASE TRANSITION 10 68 3.793e-13 1.713e-11
104 DNA REPLICATION INITIATION 8 29 4.038e-13 1.806e-11
105 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 13 171 5.669e-13 2.512e-11
106 CELL DEATH 25 1001 6.691e-13 2.937e-11
107 CELLULAR RESPONSE TO RADIATION 12 137 8.625e-13 3.751e-11
108 CELL PROLIFERATION 21 672 9.997e-13 4.307e-11
109 NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 12 139 1.027e-12 4.382e-11
110 POSITIVE REGULATION OF CATABOLIC PROCESS 17 395 1.282e-12 5.423e-11
111 POSITIVE REGULATION OF FIBROBLAST PROLIFERATION 9 53 1.537e-12 6.442e-11
112 REGULATION OF DNA METABOLIC PROCESS 16 340 1.637e-12 6.802e-11
113 REGULATION OF PROTEIN LOCALIZATION 24 950 1.689e-12 6.894e-11
114 NEGATIVE REGULATION OF MITOTIC NUCLEAR DIVISION 8 34 1.678e-12 6.894e-11
115 SISTER CHROMATID COHESION 11 111 2.078e-12 8.406e-11
116 REGULATION OF PROTEASOMAL UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 12 148 2.177e-12 8.723e-11
117 REGULATION OF INTRACELLULAR TRANSPORT 20 621 2.193e-12 8.723e-11
118 REGULATION OF FIBROBLAST PROLIFERATION 10 81 2.339e-12 9.225e-11
119 DNA REPAIR 18 480 2.616e-12 1.023e-10
120 NEGATIVE REGULATION OF PHOSPHORYLATION 17 422 3.68e-12 1.427e-10
121 POSITIVE REGULATION OF CELL PROLIFERATION 22 814 4.64e-12 1.784e-10
122 NEGATIVE REGULATION OF CELL DIVISION 9 60 5e-12 1.907e-10
123 REGULATION OF DNA REPLICATION 12 161 5.931e-12 2.244e-10
124 RESPONSE TO OXYGEN LEVELS 15 311 6.132e-12 2.301e-10
125 CELLULAR RESPONSE TO LIGHT STIMULUS 10 91 7.725e-12 2.875e-10
126 RESPONSE TO UV 11 126 8.457e-12 3.123e-10
127 PEPTIDYL AMINO ACID MODIFICATION 22 841 8.789e-12 3.195e-10
128 PHOSPHORYLATION 26 1228 8.777e-12 3.195e-10
129 POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION 12 167 9.149e-12 3.3e-10
130 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION 11 128 1.006e-11 3.6e-10
131 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 24 1036 1.051e-11 3.705e-10
132 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 24 1036 1.051e-11 3.705e-10
133 POSITIVE REGULATION OF RESPONSE TO STIMULUS 32 1929 1.111e-11 3.887e-10
134 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 22 873 1.818e-11 6.314e-10
135 REGULATION OF TRANSCRIPTION INVOLVED IN G1 S TRANSITION OF MITOTIC CELL CYCLE 7 27 2.07e-11 7.134e-10
136 NEGATIVE REGULATION OF NUCLEAR DIVISION 8 46 2.31e-11 7.904e-10
137 REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 12 181 2.362e-11 8.023e-10
138 RESPONSE TO RADIATION 16 413 3.051e-11 1.029e-09
139 POSITIVE REGULATION OF CELL COMMUNICATION 28 1532 3.623e-11 1.213e-09
140 NEGATIVE REGULATION OF CELL PROLIFERATION 19 643 3.732e-11 1.241e-09
141 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 23 1004 3.91e-11 1.29e-09
142 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 30 1784 4.507e-11 1.477e-09
143 POSITIVE REGULATION OF CHROMOSOME ORGANIZATION 11 150 5.691e-11 1.852e-09
144 PROTEIN CATABOLIC PROCESS 18 579 5.782e-11 1.868e-09
145 NEGATIVE REGULATION OF DNA REPLICATION 8 55 1.044e-10 3.35e-09
146 CELLULAR RESPONSE TO ABIOTIC STIMULUS 13 263 1.306e-10 4.162e-09
147 POSITIVE REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 7 36 1.884e-10 5.965e-09
148 REGULATION OF MITOCHONDRION ORGANIZATION 12 218 2.06e-10 6.477e-09
149 MITOTIC SISTER CHROMATID SEGREGATION 9 91 2.374e-10 7.413e-09
150 MITOCHONDRIAL TRANSPORT 11 177 3.386e-10 1.05e-08
151 APOPTOTIC SIGNALING PATHWAY 13 289 4.173e-10 1.286e-08
152 DNA DEPENDENT DNA REPLICATION 9 99 5.095e-10 1.56e-08
153 MEIOTIC CELL CYCLE 11 186 5.748e-10 1.748e-08
154 RESPONSE TO DRUG 15 431 5.949e-10 1.798e-08
155 REGULATION OF CELLULAR LOCALIZATION 24 1277 7.675e-10 2.304e-08
156 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 8 71 8.617e-10 2.57e-08
157 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 26 1517 8.975e-10 2.66e-08
158 NEGATIVE REGULATION OF KINASE ACTIVITY 12 250 9.907e-10 2.903e-08
159 SPINDLE CHECKPOINT 6 25 1.011e-09 2.903e-08
160 DIGESTIVE SYSTEM DEVELOPMENT 10 148 9.992e-10 2.903e-08
161 REGULATION OF CELLULAR RESPONSE TO STRESS 18 691 9.952e-10 2.903e-08
162 POSITIVE REGULATION OF CHROMOSOME SEGREGATION 6 25 1.011e-09 2.903e-08
163 REPLICATIVE SENESCENCE 5 12 1.136e-09 3.243e-08
164 RESPONSE TO LIPID 20 888 1.261e-09 3.576e-08
165 INTRINSIC APOPTOTIC SIGNALING PATHWAY 10 152 1.297e-09 3.635e-08
166 MEIOTIC CELL CYCLE PROCESS 10 152 1.297e-09 3.635e-08
167 NEGATIVE REGULATION OF DNA METABOLIC PROCESS 9 111 1.425e-09 3.971e-08
168 PROTEIN K11 LINKED UBIQUITINATION 6 27 1.677e-09 4.646e-08
169 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 21 1008 1.82e-09 5.011e-08
170 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 7 50 2.146e-09 5.872e-08
171 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 29 1977 2.643e-09 7.192e-08
172 POSITIVE REGULATION OF KINASE ACTIVITY 15 482 2.738e-09 7.406e-08
173 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 9 121 3.074e-09 8.269e-08
174 POSITIVE REGULATION OF TRANSPORT 20 936 3.108e-09 8.312e-08
175 RESPONSE TO STEROID HORMONE 15 497 4.142e-09 1.101e-07
176 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 9 126 4.402e-09 1.164e-07
177 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 17 684 6.257e-09 1.645e-07
178 REGULATION OF APOPTOTIC SIGNALING PATHWAY 13 363 6.591e-09 1.723e-07
179 POSITIVE REGULATION OF CELL DIVISION 9 132 6.639e-09 1.726e-07
180 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 6 34 7.435e-09 1.922e-07
181 RESPONSE TO ENDOGENOUS STIMULUS 24 1450 9.45e-09 2.429e-07
182 REGULATION OF MICROTUBULE BASED PROCESS 11 243 9.545e-09 2.44e-07
183 NEGATIVE REGULATION OF CHROMOSOME ORGANIZATION 8 96 9.825e-09 2.498e-07
184 RESPONSE TO ORGANIC CYCLIC COMPOUND 19 917 1.36e-08 3.42e-07
185 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 8 100 1.359e-08 3.42e-07
186 NEGATIVE REGULATION OF ORGANELLE ORGANIZATION 13 387 1.411e-08 3.53e-07
187 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 14 465 1.485e-08 3.695e-07
188 MACROMOLECULE CATABOLIC PROCESS 19 926 1.59e-08 3.936e-07
189 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 10 207 2.538e-08 6.249e-07
190 NEGATIVE REGULATION OF PROTEIN CATABOLIC PROCESS 8 109 2.687e-08 6.581e-07
191 REGULATION OF CYTOSKELETON ORGANIZATION 14 502 3.866e-08 9.417e-07
192 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 8 115 4.096e-08 9.84e-07
193 PROTEIN SUMOYLATION 8 115 4.096e-08 9.84e-07
194 RESPONSE TO LIGHT STIMULUS 11 280 4.103e-08 9.84e-07
195 RESPONSE TO ESTROGEN 10 218 4.143e-08 9.885e-07
196 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 11 282 4.412e-08 1.047e-06
197 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 10 220 4.515e-08 1.067e-06
198 REGULATION OF EPITHELIAL CELL PROLIFERATION 11 285 4.914e-08 1.155e-06
199 RESPONSE TO HORMONE 18 893 5.304e-08 1.24e-06
200 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 26 1848 5.435e-08 1.265e-06
201 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 11 289 5.663e-08 1.311e-06
202 REGULATION OF MICROTUBULE POLYMERIZATION OR DEPOLYMERIZATION 9 178 8.938e-08 2.059e-06
203 PROTEIN UBIQUITINATION 15 629 9.357e-08 2.145e-06
204 MEIOSIS I 7 88 1.192e-07 2.718e-06
205 POSITIVE REGULATION OF DNA METABOLIC PROCESS 9 185 1.243e-07 2.822e-06
206 REPRODUCTION 21 1297 1.439e-07 3.251e-06
207 RESPONSE TO GROWTH FACTOR 13 475 1.542e-07 3.465e-06
208 GLAND DEVELOPMENT 12 395 1.585e-07 3.545e-06
209 SMAD PROTEIN SIGNAL TRANSDUCTION 6 56 1.661e-07 3.699e-06
210 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 10 258 2.001e-07 4.434e-06
211 NEGATIVE REGULATION OF PROTEOLYSIS 11 329 2.093e-07 4.616e-06
212 NEGATIVE REGULATION OF CELL DEATH 17 872 2.119e-07 4.651e-06
213 PROTEOLYSIS 20 1208 2.131e-07 4.656e-06
214 REGULATION OF CELL CYCLE G2 M PHASE TRANSITION 6 59 2.281e-07 4.96e-06
215 MITOTIC CELL CYCLE ARREST 4 13 2.427e-07 5.253e-06
216 RESPONSE TO IONIZING RADIATION 8 145 2.478e-07 5.337e-06
217 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 7 99 2.687e-07 5.736e-06
218 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 7 99 2.687e-07 5.736e-06
219 PEPTIDYL SERINE MODIFICATION 8 148 2.899e-07 6.16e-06
220 G2 DNA DAMAGE CHECKPOINT 5 33 3.166e-07 6.696e-06
221 POSITIVE REGULATION OF MITOTIC SISTER CHROMATID SEPARATION 4 14 3.386e-07 7.066e-06
222 POSITIVE REGULATION OF MITOTIC METAPHASE ANAPHASE TRANSITION 4 14 3.386e-07 7.066e-06
223 POSITIVE REGULATION OF METAPHASE ANAPHASE TRANSITION OF CELL CYCLE 4 14 3.386e-07 7.066e-06
224 NEGATIVE REGULATION OF GENE EXPRESSION 22 1493 3.473e-07 7.214e-06
225 NEGATIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 6 64 3.73e-07 7.714e-06
226 REGULATION OF BINDING 10 283 4.689e-07 9.654e-06
227 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 6 67 4.913e-07 1.007e-05
228 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 9 218 4.991e-07 1.019e-05
229 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 8 162 5.781e-07 1.175e-05
230 MESENCHYME MORPHOGENESIS 5 38 6.581e-07 1.331e-05
231 REGULATION OF STEM CELL DIFFERENTIATION 7 113 6.634e-07 1.336e-05
232 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 15 740 7.447e-07 1.494e-05
233 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 11 381 8.944e-07 1.786e-05
234 REGULATION OF DNA DEPENDENT DNA REPLICATION 5 41 9.724e-07 1.934e-05
235 REGULATION OF CELLULAR RESPONSE TO HEAT 6 76 1.043e-06 2.065e-05
236 REGULATION OF RESPONSE TO STRESS 21 1468 1.108e-06 2.184e-05
237 PEPTIDYL LYSINE MODIFICATION 10 312 1.139e-06 2.236e-05
238 REGULATION OF CELL GROWTH 11 391 1.152e-06 2.252e-05
239 REGULATION OF CYTOPLASMIC TRANSPORT 12 481 1.28e-06 2.492e-05
240 POSITIVE REGULATION OF PROTEIN EXPORT FROM NUCLEUS 4 19 1.289e-06 2.5e-05
241 PROTEIN LOCALIZATION TO CHROMOSOME 5 45 1.564e-06 3.019e-05
242 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 7 129 1.622e-06 3.119e-05
243 ORGAN REGENERATION 6 83 1.757e-06 3.363e-05
244 GROWTH 11 410 1.826e-06 3.483e-05
245 POSITIVE REGULATION OF CHROMATIN MODIFICATION 6 85 2.021e-06 3.838e-05
246 POSITIVE REGULATION OF DNA REPLICATION 6 86 2.165e-06 4.086e-05
247 POSITIVE REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 5 48 2.169e-06 4.086e-05
248 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 10 337 2.276e-06 4.27e-05
249 CELLULAR RESPONSE TO EXTERNAL STIMULUS 9 264 2.444e-06 4.548e-05
250 AGING 9 264 2.444e-06 4.548e-05
251 RESPONSE TO GAMMA RADIATION 5 50 2.665e-06 4.941e-05
252 POSITIVE REGULATION OF MITOTIC NUCLEAR DIVISION 5 51 2.945e-06 5.437e-05
253 MICROTUBULE CYTOSKELETON ORGANIZATION 10 348 3.03e-06 5.573e-05
254 NEGATIVE REGULATION OF CATABOLIC PROCESS 8 203 3.148e-06 5.767e-05
255 CELLULAR RESPONSE TO OXYGEN LEVELS 7 143 3.228e-06 5.89e-05
256 CELLULAR RESPONSE TO IONIZING RADIATION 5 52 3.247e-06 5.901e-05
257 REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 7 145 3.54e-06 6.409e-05
258 INTRINSIC APOPTOTIC SIGNALING PATHWAY BY P53 CLASS MEDIATOR 5 53 3.572e-06 6.443e-05
259 REGULATION OF DNA BIOSYNTHETIC PROCESS 6 94 3.646e-06 6.549e-05
260 RESPONSE TO ESTRADIOL 7 146 3.705e-06 6.631e-05
261 CELLULAR CATABOLIC PROCESS 19 1322 3.751e-06 6.688e-05
262 REGULATION OF GROWTH 13 633 3.841e-06 6.821e-05
263 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 6 95 3.878e-06 6.86e-05
264 HISTONE PHOSPHORYLATION 4 25 4.124e-06 7.269e-05
265 RESPONSE TO ALCOHOL 10 362 4.298e-06 7.547e-05
266 POSITIVE REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 6 98 4.647e-06 8.129e-05
267 RESPONSE TO NITROGEN COMPOUND 15 859 4.682e-06 8.158e-05
268 REGULATION OF CHROMATIN ORGANIZATION 7 152 4.836e-06 8.397e-05
269 CELLULAR RESPONSE TO LIPID 11 457 5.169e-06 8.941e-05
270 CELLULAR RESPONSE TO HORMONE STIMULUS 12 552 5.282e-06 9.103e-05
271 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 8 218 5.33e-06 9.152e-05
272 CELLULAR MACROMOLECULE LOCALIZATION 18 1234 5.783e-06 9.894e-05
273 CHROMATIN ORGANIZATION 13 663 6.339e-06 0.000108
274 RHYTHMIC PROCESS 9 298 6.543e-06 0.000111
275 CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES 6 104 6.559e-06 0.000111
276 REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 5 60 6.636e-06 0.0001119
277 REGENERATION 7 161 7.063e-06 0.0001182
278 RESPONSE TO OXYGEN CONTAINING COMPOUND 19 1381 7.053e-06 0.0001182
279 REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 7 162 7.356e-06 0.0001222
280 TISSUE DEVELOPMENT 20 1518 7.349e-06 0.0001222
281 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 8 229 7.647e-06 0.0001253
282 NEGATIVE REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 4 29 7.64e-06 0.0001253
283 REGULATION OF EXTRACELLULAR MATRIX ORGANIZATION 4 29 7.64e-06 0.0001253
284 REGULATION OF HEART MORPHOGENESIS 4 29 7.64e-06 0.0001253
285 SOMITOGENESIS 5 62 7.809e-06 0.000127
286 POSITIVE REGULATION OF NUCLEAR DIVISION 5 62 7.809e-06 0.000127
287 PROTEIN COMPLEX SUBUNIT ORGANIZATION 20 1527 8.024e-06 0.0001301
288 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 17 1142 8.431e-06 0.0001362
289 IMMUNE SYSTEM DEVELOPMENT 12 582 9.015e-06 0.0001451
290 NEGATIVE REGULATION OF CELL GROWTH 7 170 1.008e-05 0.0001618
291 NOTCH SIGNALING PATHWAY 6 114 1.113e-05 0.000178
292 POSITIVE REGULATION OF NEURON DEATH 5 67 1.146e-05 0.0001819
293 CELL AGING 5 67 1.146e-05 0.0001819
294 PROTEIN POLYUBIQUITINATION 8 243 1.178e-05 0.0001864
295 REGULATION OF PROTEIN EXPORT FROM NUCLEUS 4 33 1.299e-05 0.0002049
296 MITOTIC SPINDLE ORGANIZATION 5 69 1.324e-05 0.000206
297 CELLULAR RESPONSE TO NITROGEN COMPOUND 11 505 1.322e-05 0.000206
298 NEGATIVE REGULATION OF CELLULAR SENESCENCE 3 11 1.324e-05 0.000206
299 ACTIVATION OF MAPKKK ACTIVITY 3 11 1.324e-05 0.000206
300 EPITHELIUM DEVELOPMENT 15 945 1.463e-05 0.0002269
301 RESPONSE TO KETONE 7 182 1.571e-05 0.0002428
302 DEVELOPMENTAL GROWTH 9 333 1.589e-05 0.0002448
303 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 13 724 1.619e-05 0.0002486
304 REGULATION OF PROTEIN IMPORT 7 183 1.628e-05 0.0002491
305 RESPONSE TO MINERALOCORTICOID 4 35 1.651e-05 0.000251
306 RESPONSE TO IRON ION 4 35 1.651e-05 0.000251
307 CELLULAR RESPONSE TO OXIDATIVE STRESS 7 184 1.686e-05 0.0002555
308 REGULATION OF MACROPHAGE CYTOKINE PRODUCTION 3 12 1.76e-05 0.0002641
309 POSITIVE REGULATION OF SMAD PROTEIN IMPORT INTO NUCLEUS 3 12 1.76e-05 0.0002641
310 MITOTIC SISTER CHROMATID COHESION 3 12 1.76e-05 0.0002641
311 MICROTUBULE BASED PROCESS 11 522 1.797e-05 0.0002689
312 MESENCHYME DEVELOPMENT 7 190 2.074e-05 0.0003093
313 REGULATION OF CELL DIFFERENTIATION 19 1492 2.105e-05 0.0003129
314 CHROMATIN MODIFICATION 11 539 2.414e-05 0.0003567
315 SOMITE DEVELOPMENT 5 78 2.411e-05 0.0003567
316 REGULATION OF TRANSPORT 21 1804 2.734e-05 0.0004026
317 POSITIVE REGULATION OF P38MAPK CASCADE 3 14 2.893e-05 0.0004246
318 TUBE DEVELOPMENT 11 552 3.003e-05 0.000438
319 REGULATION OF CELL MORPHOGENESIS 11 552 3.003e-05 0.000438
320 INTERSPECIES INTERACTION BETWEEN ORGANISMS 12 662 3.224e-05 0.0004674
321 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 12 662 3.224e-05 0.0004674
322 MEMBRANE ORGANIZATION 14 899 3.602e-05 0.0005193
323 ACTIVATION OF ANAPHASE PROMOTING COMPLEX ACTIVITY 3 15 3.605e-05 0.0005193
324 HEART DEVELOPMENT 10 466 3.811e-05 0.0005472
325 CELL DEVELOPMENT 18 1426 4.068e-05 0.0005824
326 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 6 144 4.187e-05 0.0005975
327 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 7 213 4.306e-05 0.0006127
328 REGULATION OF SMAD PROTEIN IMPORT INTO NUCLEUS 3 16 4.422e-05 0.0006217
329 REGULATION OF EXIT FROM MITOSIS 3 16 4.422e-05 0.0006217
330 NEGATIVE REGULATION OF DNA DEPENDENT DNA REPLICATION 3 16 4.422e-05 0.0006217
331 CELLULAR RESPONSE TO ANTIBIOTIC 3 16 4.422e-05 0.0006217
332 SEGMENTATION 5 89 4.563e-05 0.0006396
333 RESPONSE TO INORGANIC SUBSTANCE 10 479 4.803e-05 0.0006708
334 MESONEPHROS DEVELOPMENT 5 90 4.815e-05 0.0006708
335 REGULATION OF PROTEIN COMPLEX DISASSEMBLY 7 217 4.845e-05 0.000673
336 NEGATIVE REGULATION OF CELL AGING 3 17 5.353e-05 0.0007369
337 POSITIVE REGULATION OF EXTRACELLULAR MATRIX ORGANIZATION 3 17 5.353e-05 0.0007369
338 REGULATION OF SISTER CHROMATID COHESION 3 17 5.353e-05 0.0007369
339 RESPONSE TO ANTIBIOTIC 4 47 5.401e-05 0.0007392
340 POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS 4 47 5.401e-05 0.0007392
341 MITOCHONDRION ORGANIZATION 11 594 5.833e-05 0.0007959
342 REGULATION OF LIPID KINASE ACTIVITY 4 48 5.873e-05 0.0007967
343 HOMOLOGOUS CHROMOSOME SEGREGATION 4 48 5.873e-05 0.0007967
344 HEAD DEVELOPMENT 12 709 6.252e-05 0.0008432
345 REGULATION OF PROTEIN TARGETING 8 307 6.239e-05 0.0008432
346 REGULATION OF UBIQUITIN PROTEIN LIGASE ACTIVITY 3 18 6.403e-05 0.0008611
347 NEGATIVE REGULATION OF CELLULAR CATABOLIC PROCESS 6 156 6.542e-05 0.0008773
348 RESPONSE TO PROGESTERONE 4 50 6.904e-05 0.0009224
349 CATABOLIC PROCESS 20 1773 6.918e-05 0.0009224
350 HEMATOPOIETIC PROGENITOR CELL DIFFERENTIATION 5 98 7.238e-05 0.0009623
351 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 9 406 7.436e-05 0.0009857
352 NEGATIVE REGULATION OF GROWTH 7 236 8.217e-05 0.001086
353 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 5 102 8.756e-05 0.001154
354 RESPONSE TO TOXIC SUBSTANCE 7 241 9.367e-05 0.001231
355 POSITIVE REGULATION OF PROTEIN IMPORT 5 104 9.601e-05 0.001258
356 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 19 1672 9.916e-05 0.001296
357 CRANIAL SKELETAL SYSTEM DEVELOPMENT 4 55 0.0001005 0.001311
358 NEGATIVE REGULATION OF PROTEIN COMPLEX DISASSEMBLY 6 170 0.0001052 0.001367
359 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 17 1395 0.0001065 0.00138
360 EPITHELIAL TO MESENCHYMAL TRANSITION 4 56 0.0001079 0.001395
361 RESPONSE TO METAL ION 8 333 0.0001098 0.001415
362 NEGATIVE REGULATION OF CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 3 22 0.0001193 0.001529
363 ENDOCARDIAL CUSHION MORPHOGENESIS 3 22 0.0001193 0.001529
364 REGULATION OF CELLULAR COMPONENT BIOGENESIS 12 767 0.0001315 0.001681
365 LYMPHOCYTE ACTIVATION 8 342 0.0001319 0.001681
366 POSITIVE REGULATION OF DNA BIOSYNTHETIC PROCESS 4 59 0.0001324 0.001683
367 MULTICELLULAR ORGANISM REPRODUCTION 12 768 0.0001331 0.001688
368 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 3 23 0.0001368 0.001725
369 POSITIVE REGULATION OF COLLAGEN METABOLIC PROCESS 3 23 0.0001368 0.001725
370 EMBRYO DEVELOPMENT 13 894 0.00014 0.001761
371 NUCLEOTIDE EXCISION REPAIR 5 113 0.0001421 0.001782
372 CELLULAR RESPONSE TO HYDROGEN PEROXIDE 4 61 0.0001508 0.001886
373 POSITIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 3 24 0.0001558 0.001933
374 POSITIVE REGULATION OF G1 S TRANSITION OF MITOTIC CELL CYCLE 3 24 0.0001558 0.001933
375 POSITIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 3 24 0.0001558 0.001933
376 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 10 554 0.0001594 0.001972
377 PROTEIN LOCALIZATION TO ORGANELLE 10 556 0.0001641 0.002025
378 CELLULAR RESPONSE TO TOXIC SUBSTANCE 3 25 0.0001765 0.002156
379 REGULATION OF TRANSFORMING GROWTH FACTOR BETA PRODUCTION 3 25 0.0001765 0.002156
380 POSITIVE REGULATION OF PEPTIDYL THREONINE PHOSPHORYLATION 3 25 0.0001765 0.002156
381 EPITHELIAL CELL APOPTOTIC PROCESS 3 25 0.0001765 0.002156
382 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 6 188 0.0001822 0.002208
383 REGULATION OF PROTEIN ACETYLATION 4 64 0.0001818 0.002208
384 POSITIVE REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 4 64 0.0001818 0.002208
385 MEIOTIC CHROMOSOME SEGREGATION 4 65 0.000193 0.002321
386 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 12 799 0.0001923 0.002321
387 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 6 190 0.000193 0.002321
388 CELL ACTIVATION 10 568 0.000195 0.002338
389 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 5 121 0.0001957 0.002341
390 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 12 801 0.0001967 0.002347
391 REGULATION OF CELLULAR SENESCENCE 3 26 0.0001989 0.002349
392 RESPONSE TO CORTICOSTERONE 3 26 0.0001989 0.002349
393 REGULATION OF P38MAPK CASCADE 3 26 0.0001989 0.002349
394 RESPONSE TO REACTIVE OXYGEN SPECIES 6 191 0.0001985 0.002349
395 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 4 66 0.0002048 0.002406
396 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 4 66 0.0002048 0.002406
397 DEVELOPMENTAL MATURATION 6 193 0.00021 0.002462
398 ANTERIOR POSTERIOR PATTERN SPECIFICATION 6 194 0.000216 0.002525
399 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 4 67 0.0002171 0.002531
400 KIDNEY EPITHELIUM DEVELOPMENT 5 125 0.0002278 0.00265
401 POSITIVE REGULATION OF BINDING 5 127 0.0002452 0.002845
402 REGULATION OF DNA DAMAGE RESPONSE SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 3 28 0.000249 0.002882
403 POSITIVE REGULATION OF CELL DIFFERENTIATION 12 823 0.0002523 0.002913
404 PROTEIN LOCALIZATION 19 1805 0.0002686 0.003093
405 INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY 4 71 0.0002715 0.003112
406 ENDODERM DEVELOPMENT 4 71 0.0002715 0.003112
407 POSITIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 3 29 0.0002769 0.003165
408 CELL MATURATION 5 131 0.0002831 0.003229
409 REGULATION OF CELL DEVELOPMENT 12 836 0.0002911 0.003311
410 TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR 4 73 0.0003021 0.003429
411 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE BY P53 CLASS MEDIATOR 3 30 0.0003067 0.003462
412 ORGAN MORPHOGENESIS 12 841 0.0003073 0.003462
413 RESPONSE TO X RAY 3 30 0.0003067 0.003462
414 ESTABLISHMENT OF LOCALIZATION IN CELL 18 1676 0.0003149 0.003539
415 LYMPHOCYTE DIFFERENTIATION 6 209 0.0003222 0.003613
416 REGULATION OF PEPTIDASE ACTIVITY 8 392 0.0003324 0.003718
417 MACROMOLECULAR COMPLEX ASSEMBLY 16 1398 0.0003562 0.003975
418 NEGATIVE REGULATION OF HYDROLASE ACTIVITY 8 397 0.0003618 0.004027
419 NEGATIVE REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 3 32 0.0003723 0.004114
420 SALIVARY GLAND DEVELOPMENT 3 32 0.0003723 0.004114
421 ENDOCARDIAL CUSHION DEVELOPMENT 3 32 0.0003723 0.004114
422 PROTEIN COMPLEX BIOGENESIS 14 1132 0.0004046 0.004451
423 PROTEIN COMPLEX ASSEMBLY 14 1132 0.0004046 0.004451
424 RESPONSE TO PEPTIDE 8 404 0.0004063 0.004459
425 REGULATION OF CELL AGING 3 33 0.0004082 0.004469
426 PROTEIN TARGETING 8 406 0.0004199 0.004586
427 RAS PROTEIN SIGNAL TRANSDUCTION 5 143 0.0004239 0.004619
428 REGULATION OF PROTEIN STABILITY 6 221 0.0004336 0.004703
429 NEGATIVE REGULATION OF CYTOSKELETON ORGANIZATION 6 221 0.0004336 0.004703
430 REGULATION OF PROTEIN DEACETYLATION 3 34 0.0004463 0.004796
431 PROTEIN DESTABILIZATION 3 34 0.0004463 0.004796
432 IN UTERO EMBRYONIC DEVELOPMENT 7 311 0.0004447 0.004796
433 HEART VALVE DEVELOPMENT 3 34 0.0004463 0.004796
434 DNA GEOMETRIC CHANGE 4 81 0.0004497 0.004821
435 LEUKOCYTE ACTIVATION 8 414 0.0004777 0.00511
436 RESPONSE TO TRANSITION METAL NANOPARTICLE 5 148 0.000496 0.005293
437 POSITIVE REGULATION OF OSSIFICATION 4 84 0.0005163 0.005497
438 POSITIVE REGULATION OF PROTEIN ACETYLATION 3 36 0.0005291 0.005608
439 HEAD MORPHOGENESIS 3 36 0.0005291 0.005608
440 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 4 86 0.0005644 0.005969
441 REGULATION OF PEPTIDYL THREONINE PHOSPHORYLATION 3 37 0.000574 0.006056
442 TISSUE REMODELING 4 87 0.0005897 0.006207
443 OVULATION CYCLE PROCESS 4 88 0.0006157 0.006452
444 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 4 88 0.0006157 0.006452
445 POSITIVE REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 3 38 0.0006212 0.006466
446 OOCYTE DIFFERENTIATION 3 38 0.0006212 0.006466
447 REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 3 38 0.0006212 0.006466
448 CELLULAR RESPONSE TO INORGANIC SUBSTANCE 5 156 0.0006301 0.006544
449 POSITIVE REGULATION OF GROWTH 6 238 0.0006406 0.006638
450 B CELL DIFFERENTIATION 4 89 0.0006425 0.006643
451 REGULATION OF DEPHOSPHORYLATION 5 158 0.0006675 0.006886
452 CELLULAR RESPONSE TO NUTRIENT 3 39 0.0006708 0.00689
453 SPLEEN DEVELOPMENT 3 39 0.0006708 0.00689
454 REGULATION OF ORGAN MORPHOGENESIS 6 242 0.0006989 0.007163
455 POSITIVE REGULATION OF CELL MATRIX ADHESION 3 40 0.0007229 0.00736
456 RESPONSE TO EXTRACELLULAR STIMULUS 8 441 0.0007224 0.00736
457 RESPONSE TO CADMIUM ION 3 40 0.0007229 0.00736
458 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 3 41 0.0007775 0.007882
459 ANDROGEN RECEPTOR SIGNALING PATHWAY 3 41 0.0007775 0.007882
460 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 17 1656 0.0007938 0.008029
461 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 15 1360 0.0008172 0.008249
462 COVALENT CHROMATIN MODIFICATION 7 345 0.0008209 0.008267
463 REGULATION OF CYTOKINE PRODUCTION 9 563 0.0008257 0.008298
464 REGULATION OF NEURON DEATH 6 252 0.0008627 0.008651
465 RESPONSE TO CARBOHYDRATE 5 168 0.00088 0.008805
466 BETA CATENIN TCF COMPLEX ASSEMBLY 3 43 0.0008944 0.008931
467 LEUKOCYTE CELL CELL ADHESION 6 255 0.0009172 0.009138
468 RESPONSE TO VITAMIN 4 98 0.0009225 0.009156
469 RESPONSE TO OXIDATIVE STRESS 7 352 0.0009229 0.009156
470 BODY MORPHOGENESIS 3 44 0.0009568 0.009465
471 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 4 99 0.0009581 0.009465
472 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 4 100 0.0009947 0.009785
473 PEPTIDYL TYROSINE DEPHOSPHORYLATION 4 100 0.0009947 0.009785
474 REGULATION OF MITOTIC SPINDLE CHECKPOINT 2 11 0.001026 0.009987
475 REGULATION OF EXTRACELLULAR MATRIX ASSEMBLY 2 11 0.001026 0.009987
476 SUBSTANTIA NIGRA DEVELOPMENT 3 45 0.001022 0.009987
477 EXOCRINE SYSTEM DEVELOPMENT 3 45 0.001022 0.009987
478 REGULATION OF MITOTIC CELL CYCLE SPINDLE ASSEMBLY CHECKPOINT 2 11 0.001026 0.009987
NumGOOverlapSizeP ValueAdj. P Value
1 ENZYME BINDING 36 1737 3.082e-16 2.863e-13
2 KINASE BINDING 23 606 1.081e-15 5.022e-13
3 PROTEIN KINASE ACTIVITY 22 640 3.81e-14 1.18e-11
4 CYCLIN DEPENDENT PROTEIN SERINE THREONINE KINASE REGULATOR ACTIVITY 8 28 2.934e-13 6.815e-11
5 PROTEIN SERINE THREONINE KINASE ACTIVITY 18 445 7.345e-13 1.365e-10
6 KINASE ACTIVITY 23 842 1.1e-12 1.46e-10
7 TRANSCRIPTION FACTOR BINDING 19 524 1.072e-12 1.46e-10
8 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 23 992 3.074e-11 3.57e-09
9 KINASE REGULATOR ACTIVITY 11 186 5.748e-10 5.933e-08
10 PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 6 30 3.329e-09 2.812e-07
11 PROTEIN COMPLEX BINDING 20 935 3.052e-09 2.812e-07
12 MACROMOLECULAR COMPLEX BINDING 24 1399 4.695e-09 3.635e-07
13 CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 6 34 7.435e-09 5.314e-07
14 ADENYL NUCLEOTIDE BINDING 23 1514 1.008e-07 6.691e-06
15 CYCLIN DEPENDENT PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 4 12 1.686e-07 1.044e-05
16 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 7 104 3.767e-07 2.188e-05
17 STEROID HORMONE RECEPTOR BINDING 6 81 1.521e-06 8.312e-05
18 KINASE INHIBITOR ACTIVITY 6 89 2.648e-06 0.0001238
19 TRANSFORMING GROWTH FACTOR BETA RECEPTOR BINDING 5 50 2.665e-06 0.0001238
20 UBIQUITIN LIKE PROTEIN LIGASE BINDING 9 264 2.444e-06 0.0001238
21 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 18 1199 3.877e-06 0.0001637
22 RIBONUCLEOTIDE BINDING 23 1860 3.713e-06 0.0001637
23 ACTIVATING TRANSCRIPTION FACTOR BINDING 5 57 5.141e-06 0.0002076
24 PROTEIN HETERODIMERIZATION ACTIVITY 11 468 6.475e-06 0.0002506
25 P53 BINDING 5 67 1.146e-05 0.0004257
26 SMAD BINDING 5 72 1.631e-05 0.0005828
27 ENZYME REGULATOR ACTIVITY 15 959 1.739e-05 0.0005929
28 RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING 4 36 1.851e-05 0.0005929
29 PROTEIN DOMAIN SPECIFIC BINDING 12 624 1.805e-05 0.0005929
30 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 12 629 1.953e-05 0.0006048
31 CHROMATIN BINDING 10 435 2.124e-05 0.0006364
32 ANDROGEN RECEPTOR BINDING 4 39 2.559e-05 0.000722
33 DNA DEPENDENT ATPASE ACTIVITY 5 79 2.565e-05 0.000722
34 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR BINDING 3 15 3.605e-05 0.0009849
35 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 11 588 5.324e-05 0.001413
36 CORE PROMOTER BINDING 6 152 5.663e-05 0.001461
37 RECEPTOR BINDING 18 1476 6.374e-05 0.0016
38 CYCLIN BINDING 3 19 7.58e-05 0.001717
39 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 8 315 7.467e-05 0.001717
40 MOLECULAR FUNCTION REGULATOR 17 1353 7.319e-05 0.001717
41 HISTONE KINASE ACTIVITY 3 19 7.58e-05 0.001717
42 PHOSPHATASE BINDING 6 162 8.064e-05 0.001784
43 DNA HELICASE ACTIVITY 4 53 8.691e-05 0.001878
44 HORMONE RECEPTOR BINDING 6 168 9.855e-05 0.002081
45 R SMAD BINDING 3 23 0.0001368 0.002824
46 PHOSPHOPROTEIN BINDING 4 60 0.0001414 0.002855
47 PROTEIN C TERMINUS BINDING 6 186 0.0001719 0.003327
48 DAMAGED DNA BINDING 4 63 0.000171 0.003327
49 REGULATORY REGION NUCLEIC ACID BINDING 12 818 0.0002386 0.004524
50 BHLH TRANSCRIPTION FACTOR BINDING 3 28 0.000249 0.004627
51 ATP DEPENDENT DNA HELICASE ACTIVITY 3 34 0.0004463 0.008129
52 PROTEIN DIMERIZATION ACTIVITY 14 1149 0.0004697 0.008392
53 BETA CATENIN BINDING 4 84 0.0005163 0.008892
54 DOUBLE STRANDED DNA BINDING 11 764 0.0005169 0.008892
NumGOOverlapSizeP ValueAdj. P Value
1 CHROMOSOME 30 880 3.235e-19 1.889e-16
2 CHROMOSOMAL REGION 20 330 1.401e-17 4.092e-15
3 NUCLEAR CHROMOSOME 23 523 4.449e-17 6.495e-15
4 TRANSCRIPTION FACTOR COMPLEX 19 298 3.884e-17 6.495e-15
5 TRANSFERASE COMPLEX 24 703 2.433e-15 2.842e-13
6 CYCLIN DEPENDENT PROTEIN KINASE HOLOENZYME COMPLEX 9 31 7.562e-15 7.36e-13
7 ANAPHASE PROMOTING COMPLEX 8 22 3.084e-14 2.573e-12
8 MICROTUBULE CYTOSKELETON 26 1068 3.7e-13 2.701e-11
9 CHROMATIN 18 441 6.308e-13 4.093e-11
10 SPINDLE 15 289 2.144e-12 1.252e-10
11 PROTEIN KINASE COMPLEX 10 90 6.9e-12 3.663e-10
12 CATALYTIC COMPLEX 24 1038 1.094e-11 4.916e-10
13 NUCLEAR UBIQUITIN LIGASE COMPLEX 8 42 1.06e-11 4.916e-10
14 CULLIN RING UBIQUITIN LIGASE COMPLEX 11 150 5.691e-11 2.374e-09
15 CHROMOSOME TELOMERIC REGION 10 162 2.412e-09 9.392e-08
16 CENTROSOME 15 487 3.148e-09 1.149e-07
17 CONDENSED NUCLEAR CHROMOSOME 8 85 3.708e-09 1.274e-07
18 CHROMOSOME CENTROMERIC REGION 10 174 4.818e-09 1.563e-07
19 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 11 237 7.363e-09 2.263e-07
20 CYTOSKELETON 28 1967 1.068e-08 3.119e-07
21 MICROTUBULE ORGANIZING CENTER 16 623 1.173e-08 3.263e-07
22 CONDENSED CHROMOSOME 10 195 1.438e-08 3.817e-07
23 UBIQUITIN LIGASE COMPLEX 11 262 2.077e-08 5.274e-07
24 CYTOSKELETAL PART 23 1436 3.835e-08 9.331e-07
25 SPINDLE POLE 8 126 8.362e-08 1.953e-06
26 MCM COMPLEX 4 11 1.128e-07 2.533e-06
27 NUCLEAR CHROMOSOME TELOMERIC REGION 8 132 1.2e-07 2.596e-06
28 CONDENSED CHROMOSOME OUTER KINETOCHORE 4 12 1.686e-07 3.516e-06
29 RNA POLYMERASE II TRANSCRIPTION FACTOR COMPLEX 7 101 3.083e-07 6.208e-06
30 CONDENSED NUCLEAR CHROMOSOME CENTROMERIC REGION 4 18 1.021e-06 1.988e-05
31 NUCLEAR TRANSCRIPTION FACTOR COMPLEX 7 127 1.461e-06 2.752e-05
32 CONDENSED CHROMOSOME CENTROMERIC REGION 6 102 5.862e-06 0.000107
33 COHESIN COMPLEX 3 11 1.324e-05 0.0002343
34 KINETOCHORE 6 120 1.493e-05 0.0002564
35 CYTOPLASMIC VESICLE PART 11 601 6.478e-05 0.001081
36 NUCLEOLUS 13 848 8.263e-05 0.00134
37 CARBOXY TERMINAL DOMAIN PROTEIN KINASE COMPLEX 3 22 0.0001193 0.001883
38 SPINDLE MIDZONE 3 27 0.000223 0.003428
39 NUCLEAR CHROMATIN 7 291 0.0002983 0.004466

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04110_Cell_cycle 88 128 1.85e-211 3.33e-209
2 hsa04114_Oocyte_meiosis 26 114 2.331e-38 2.098e-36
3 hsa04115_p53_signaling_pathway 19 69 8.182e-30 4.909e-28
4 hsa04350_TGF.beta_signaling_pathway 16 85 2.893e-22 1.302e-20
5 hsa04914_Progesterone.mediated_oocyte_maturation 16 87 4.326e-22 1.557e-20
6 hsa04390_Hippo_signaling_pathway 17 154 1.83e-19 5.489e-18
7 hsa04151_PI3K_AKT_signaling_pathway 20 351 4.656e-17 1.197e-15
8 hsa04310_Wnt_signaling_pathway 12 151 2.766e-12 6.224e-11
9 hsa04120_Ubiquitin_mediated_proteolysis 10 139 5.397e-10 1.079e-08
10 hsa04722_Neurotrophin_signaling_pathway 9 127 4.721e-09 8.498e-08
11 hsa03030_DNA_replication 5 36 4.977e-07 8.145e-06
12 hsa04010_MAPK_signaling_pathway 9 268 2.764e-06 4.146e-05
13 hsa04520_Adherens_junction 5 73 1.745e-05 0.0002416
14 hsa04012_ErbB_signaling_pathway 5 87 4.09e-05 0.0005259
15 hsa04630_Jak.STAT_signaling_pathway 6 155 6.313e-05 0.0007575
16 hsa04144_Endocytosis 6 203 0.0002757 0.003101
17 hsa03420_Nucleotide_excision_repair 3 45 0.001022 0.01082
18 hsa04916_Melanogenesis 3 101 0.01006 0.1006
19 hsa04510_Focal_adhesion 4 200 0.01178 0.1116
20 hsa04330_Notch_signaling_pathway 2 47 0.0182 0.1638
21 hsa04720_Long.term_potentiation 2 70 0.03811 0.3266
22 hsa04210_Apoptosis 2 89 0.0586 0.4687
23 hsa04380_Osteoclast_differentiation 2 128 0.1092 0.7467
24 hsa04360_Axon_guidance 2 130 0.112 0.7467

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 LINC00941 hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-27b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-335-5p;hsa-miR-340-5p;hsa-miR-374a-3p;hsa-miR-378a-3p;hsa-miR-497-5p 22 CDK6 Sponge network 4.292 0 0.944 0 0.658
2 AC007879.5 hsa-miR-101-3p;hsa-miR-146a-5p;hsa-miR-148a-5p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-34a-5p;hsa-miR-502-3p 12 CDK6 Sponge network 2.671 0 0.944 0 0.595
3 AC007879.7 hsa-miR-101-3p;hsa-miR-140-3p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-27b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-340-5p 18 CDK6 Sponge network 2.7 0 0.944 0 0.587
4 RP11-221N13.3 hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-142-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-27b-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-9-5p 15 CDK6 Sponge network 5.876 0 0.944 0 0.56
5

RP11-150O12.1

hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-16-5p;hsa-miR-195-5p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-335-5p 17 CDK6 Sponge network 1.523 0 0.944 0 0.534
6

RP11-30P6.6

hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-3p;hsa-miR-30d-5p;hsa-miR-30e-3p;hsa-miR-30e-5p;hsa-miR-374a-5p;hsa-miR-378a-3p;hsa-miR-429;hsa-miR-660-5p 28 CDK6 Sponge network 2.847 0 0.944 0 0.53
7 CTD-2547L24.4 hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-27b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-378a-3p 13 CDK6 Sponge network 1.587 0 0.944 0 0.508
8

LINC00707

hsa-miR-106a-5p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-3p;hsa-miR-30d-5p;hsa-miR-30e-3p;hsa-miR-30e-5p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-340-5p;hsa-miR-34a-5p;hsa-miR-374a-3p;hsa-miR-378a-3p;hsa-miR-429;hsa-miR-497-5p;hsa-miR-664a-3p 31 CDK6 Sponge network 2.018 1.0E-5 0.944 0 0.503
9

AC011738.4

hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-16-5p;hsa-miR-191-5p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-27b-3p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-320a;hsa-miR-34a-5p;hsa-miR-374a-3p;hsa-miR-378a-3p;hsa-miR-497-5p;hsa-miR-664a-3p;hsa-miR-7-1-3p;hsa-miR-9-5p 25 CDK6 Sponge network 3.153 0 0.944 0 0.489
10

RP5-1198O20.4

hsa-miR-125a-5p;hsa-miR-140-3p;hsa-miR-217;hsa-miR-28-5p;hsa-miR-30a-5p;hsa-miR-328-3p;hsa-miR-335-3p;hsa-miR-374a-3p;hsa-miR-582-3p;hsa-miR-664a-3p 10 YWHAZ Sponge network 0.114 0.54508 0.345 0.0016 0.481
11 RP11-890B15.2 hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-34a-5p;hsa-miR-374a-3p;hsa-miR-497-5p;hsa-miR-9-5p 21 CDK6 Sponge network 4.029 0 0.944 0 0.474
12 RP5-884M6.1 hsa-miR-101-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-27b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-378a-3p 18 CDK6 Sponge network 6.548 0 0.944 0 0.471
13 RP13-463N16.6 hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-146a-5p;hsa-miR-148a-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-30a-3p;hsa-miR-30a-5p 11 CDK6 Sponge network 3.312 0 0.944 0 0.463
14 MIR31HG hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-148a-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-23b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-34a-5p 11 CDK6 Sponge network 0.768 0.15574 0.944 0 0.463
15 RP11-462L8.1 hsa-miR-101-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-34a-5p;hsa-miR-9-5p 13 CDK6 Sponge network 4.262 0 0.944 0 0.453
16 RP11-417E7.1 hsa-miR-106a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-26a-5p;hsa-miR-30a-3p;hsa-miR-30a-5p 11 CDK6 Sponge network 3.987 0 0.944 0 0.449
17 CTD-2066L21.3 hsa-miR-101-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-200b-3p;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-3p;hsa-miR-30d-5p;hsa-miR-30e-3p;hsa-miR-30e-5p;hsa-miR-335-5p;hsa-miR-9-5p 19 CDK6 Sponge network 5.449 0 0.944 0 0.447
18 RP1-193H18.2 hsa-let-7a-3p;hsa-miR-130a-3p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-21-3p;hsa-miR-224-5p;hsa-miR-2355-5p;hsa-miR-27a-3p;hsa-miR-450b-5p;hsa-miR-576-5p 10 SMAD4 Sponge network -1.539 0 -0.43 0 0.443
19

FAM83A-AS1

hsa-let-7a-5p;hsa-let-7c-5p;hsa-let-7d-5p;hsa-let-7f-5p;hsa-let-7g-5p;hsa-let-7i-5p;hsa-miR-101-3p;hsa-miR-106b-5p;hsa-miR-20b-5p;hsa-miR-28-5p;hsa-miR-491-5p 11 CDKN1A Sponge network 1.064 0.00307 0.128 0.35863 0.44
20 LINC00518 hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-146a-5p;hsa-miR-148a-5p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p 13 CDK6 Sponge network 2.747 4.0E-5 0.944 0 0.436
21

LINC00707

hsa-miR-195-3p;hsa-miR-217;hsa-miR-28-5p;hsa-miR-30a-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-328-3p;hsa-miR-335-3p;hsa-miR-374a-3p;hsa-miR-378a-3p;hsa-miR-664a-3p 13 YWHAZ Sponge network 2.018 1.0E-5 0.345 0.0016 0.436
22 RP11-445F12.1 hsa-miR-140-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-340-5p;hsa-miR-497-5p 15 CDK6 Sponge network 7.107 0 0.944 0 0.435
23

RP11-218E20.3

hsa-miR-101-3p;hsa-miR-140-3p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30b-5p;hsa-miR-30d-3p;hsa-miR-30d-5p;hsa-miR-30e-3p;hsa-miR-30e-5p;hsa-miR-32-5p;hsa-miR-374a-5p;hsa-miR-374b-5p;hsa-miR-497-5p 24 CDK6 Sponge network 4.613 0 0.944 0 0.434
24 RP11-42I10.1 hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-27b-3p;hsa-miR-30a-3p;hsa-miR-30a-5p 15 CDK6 Sponge network 2.1 0 0.944 0 0.432
25 LINC00704 hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-30a-3p;hsa-miR-30e-3p 12 CDK6 Sponge network 2.465 0 0.944 0 0.43
26

MAGI2-AS3

hsa-miR-141-3p;hsa-miR-142-3p;hsa-miR-149-5p;hsa-miR-200a-3p;hsa-miR-29b-3p;hsa-miR-33a-3p;hsa-miR-362-5p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-500a-5p;hsa-miR-500b-5p;hsa-miR-589-3p;hsa-miR-944 13 TGFB2 Sponge network -0.939 4.0E-5 0.078 0.72302 0.43
27 LINC00460 hsa-miR-140-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-27b-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-429;hsa-miR-497-5p 16 CDK6 Sponge network 7.222 0 0.944 0 0.425
28 LINC00958 hsa-miR-140-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-26a-5p;hsa-miR-30a-3p;hsa-miR-340-5p;hsa-miR-374a-3p;hsa-miR-497-5p 11 CDK6 Sponge network 1.836 0 0.944 0 0.422
29 XXyac-YX65C7_A.3 hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30b-5p;hsa-miR-30d-5p;hsa-miR-30e-5p 17 CDK6 Sponge network 6.112 0 0.944 0 0.418
30

KB-1732A1.1

hsa-let-7a-5p;hsa-let-7c-5p;hsa-let-7f-5p;hsa-let-7g-5p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-20b-5p;hsa-miR-28-5p;hsa-miR-30b-3p;hsa-miR-429;hsa-miR-491-5p 12 CDKN1A Sponge network 1.697 0 0.128 0.35863 0.417
31 CTD-2587H24.5 hsa-miR-101-3p;hsa-miR-140-3p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-30a-3p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-497-5p;hsa-miR-582-5p 20 CDK6 Sponge network 7.138 0 0.944 0 0.417
32 KTN1-AS1 hsa-miR-101-3p;hsa-miR-140-3p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-20b-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-34a-5p;hsa-miR-378a-3p 16 CDK6 Sponge network 1.107 0 0.944 0 0.412
33 RP11-1020M18.10 hsa-miR-106a-5p;hsa-miR-146a-5p;hsa-miR-195-5p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-30a-3p;hsa-miR-497-5p;hsa-miR-582-5p 10 CDK6 Sponge network 6.911 0 0.944 0 0.404
34 TTLL11-IT1 hsa-miR-140-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-200b-3p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-30a-3p;hsa-miR-30a-5p 11 CDK6 Sponge network 5.5 0 0.944 0 0.397
35 AC108142.1 hsa-miR-101-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-191-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-29c-3p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-34a-5p;hsa-miR-362-5p;hsa-miR-374a-5p;hsa-miR-374b-5p;hsa-miR-429;hsa-miR-7-1-3p 24 CDK6 Sponge network 2.31 0 0.944 0 0.396
36

LINC00702

hsa-miR-141-3p;hsa-miR-142-3p;hsa-miR-149-5p;hsa-miR-200a-3p;hsa-miR-33a-3p;hsa-miR-454-3p;hsa-miR-500a-5p;hsa-miR-500b-5p;hsa-miR-589-3p;hsa-miR-590-5p 10 TGFB2 Sponge network -0.573 0.0699 0.078 0.72302 0.396
37

KB-1732A1.1

hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-378a-3p;hsa-miR-429;hsa-miR-497-5p 23 CDK6 Sponge network 1.697 0 0.944 0 0.394
38

RP11-557H15.3

hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-26a-5p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-335-3p;hsa-miR-340-5p;hsa-miR-374b-5p;hsa-miR-378a-3p 15 CDK6 Sponge network 1.673 8.0E-5 0.944 0 0.393
39 RP11-366H4.1 hsa-miR-101-3p;hsa-miR-148a-3p;hsa-miR-195-5p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-30a-3p;hsa-miR-340-5p;hsa-miR-374a-5p;hsa-miR-497-5p 12 CDK6 Sponge network 4.872 0 0.944 0 0.39
40

RP11-554I8.2

hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-29c-3p;hsa-miR-378a-3p 14 CDK6 Sponge network 0.342 0.50007 0.944 0 0.389
41

CTD-2555C10.3

hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-29c-3p;hsa-miR-30a-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-664a-3p 14 CDK6 Sponge network 1.037 0.0004 0.944 0 0.389
42 RP11-346D19.1 hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-30a-3p;hsa-miR-340-5p 11 CDK6 Sponge network 6.549 0 0.944 0 0.38
43 CTD-2357A8.3 hsa-miR-101-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-335-5p;hsa-miR-34a-5p 11 CDK6 Sponge network 7.162 0 0.944 0 0.38
44

APCDD1L-AS1

hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-335-3p;hsa-miR-378a-3p;hsa-miR-497-5p;hsa-miR-7-1-3p;hsa-miR-9-5p 24 CDK6 Sponge network 2.077 0 0.944 0 0.379
45

CTD-2555C10.3

hsa-let-7a-5p;hsa-let-7c-5p;hsa-let-7f-5p;hsa-let-7g-5p;hsa-let-7i-5p;hsa-miR-106b-5p;hsa-miR-20b-5p;hsa-miR-28-5p;hsa-miR-30b-3p;hsa-miR-491-5p 10 CDKN1A Sponge network 1.037 0.0004 0.128 0.35863 0.379
46

MAGI2-AS3

hsa-let-7a-3p;hsa-miR-130a-3p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-21-3p;hsa-miR-224-5p;hsa-miR-2355-5p;hsa-miR-27a-3p;hsa-miR-454-3p;hsa-miR-576-5p 10 SMAD4 Sponge network -0.939 4.0E-5 -0.43 0 0.379
47

NOP14-AS1

hsa-miR-101-3p;hsa-miR-140-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30b-5p;hsa-miR-30d-3p;hsa-miR-30d-5p;hsa-miR-30e-3p;hsa-miR-30e-5p;hsa-miR-335-5p;hsa-miR-340-5p;hsa-miR-34a-5p;hsa-miR-374a-3p;hsa-miR-378a-3p;hsa-miR-497-5p;hsa-miR-502-3p 25 CDK6 Sponge network 0.939 0 0.944 0 0.374
48

AC006262.4

hsa-miR-106a-5p;hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-16-5p;hsa-miR-195-5p;hsa-miR-20b-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-497-5p;hsa-miR-582-5p 15 CDK6 Sponge network 1.721 0.01526 0.944 0 0.373
49

RP11-497E19.1

hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-191-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-29c-3p;hsa-miR-335-3p;hsa-miR-664a-3p;hsa-miR-7-1-3p 19 CDK6 Sponge network 2.366 0.00063 0.944 0 0.373
50

RP11-150O12.1

hsa-let-7c-5p;hsa-let-7d-5p;hsa-let-7f-5p;hsa-let-7g-5p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-20b-5p;hsa-miR-28-5p;hsa-miR-30b-3p;hsa-miR-335-5p;hsa-miR-423-5p 11 CDKN1A Sponge network 1.523 0 0.128 0.35863 0.369
51

RP11-58E21.3

hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-148a-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30d-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-362-5p 14 CDK6 Sponge network 0.445 0.04375 0.944 0 0.365
52

RP11-58E21.3

hsa-let-7c-5p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-20b-5p;hsa-miR-28-5p;hsa-miR-30b-3p;hsa-miR-335-5p;hsa-miR-345-5p;hsa-miR-491-5p;hsa-miR-93-5p 11 CDKN1A Sponge network 0.445 0.04375 0.128 0.35863 0.36
53 AC005682.5 hsa-miR-101-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30e-3p;hsa-miR-340-5p 12 CDK6 Sponge network 1.074 0 0.944 0 0.358
54 LINC00973 hsa-miR-101-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-200b-3p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-335-5p 10 CDK6 Sponge network 5.015 0 0.944 0 0.357
55 VPS9D1-AS1 hsa-miR-101-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-20b-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-30a-3p;hsa-miR-378a-3p;hsa-miR-497-5p 10 CDK6 Sponge network 1.07 1.0E-5 0.944 0 0.353
56 RP11-145A3.1 hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-20b-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-30a-3p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-335-3p 14 CDK6 Sponge network 2.565 0 0.944 0 0.353
57

RP11-30P6.6

hsa-miR-140-3p;hsa-miR-148a-3p;hsa-miR-181c-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-30a-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p 10 YWHAG Sponge network 2.847 0 0.33 0.00014 0.353
58 BHLHE40-AS1 hsa-let-7a-3p;hsa-miR-130a-3p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-224-5p;hsa-miR-2355-5p;hsa-miR-27a-3p;hsa-miR-450b-5p;hsa-miR-576-5p;hsa-miR-590-5p 10 SMAD4 Sponge network -0.932 0 -0.43 0 0.353
59

RP11-227H15.4

hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-16-5p;hsa-miR-195-5p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-335-5p;hsa-miR-34a-5p;hsa-miR-374a-3p;hsa-miR-497-5p 22 CDK6 Sponge network 4.405 0 0.944 0 0.352
60 LUCAT1 hsa-miR-101-3p;hsa-miR-148a-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-335-5p;hsa-miR-429;hsa-miR-660-5p 16 CDK6 Sponge network 1.475 0 0.944 0 0.351
61 MIR22HG hsa-let-7a-5p;hsa-let-7d-5p;hsa-let-7f-5p;hsa-let-7g-5p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-28-5p;hsa-miR-345-5p;hsa-miR-582-5p;hsa-miR-93-5p 10 CDKN1A Sponge network -0.601 4.0E-5 0.128 0.35863 0.348
62

FAM83A-AS1

hsa-miR-101-3p;hsa-miR-148a-3p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-335-3p;hsa-miR-378a-3p 14 CDK6 Sponge network 1.064 0.00307 0.944 0 0.343
63 RP11-479G22.8 hsa-miR-101-3p;hsa-miR-140-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-335-3p;hsa-miR-429 17 CDK6 Sponge network 0.955 0 0.944 0 0.342
64

LINC00707

hsa-let-7c-5p;hsa-let-7g-5p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-20b-5p;hsa-miR-28-5p;hsa-miR-30b-3p;hsa-miR-335-5p;hsa-miR-345-5p;hsa-miR-363-3p;hsa-miR-429;hsa-miR-491-5p 12 CDKN1A Sponge network 2.018 1.0E-5 0.128 0.35863 0.338
65 RP11-285E9.6 hsa-miR-101-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-30a-3p;hsa-miR-497-5p 10 CDK6 Sponge network 1.44 1.0E-5 0.944 0 0.336
66 RP11-11N5.1 hsa-miR-140-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-335-5p 10 CDK6 Sponge network 5.005 0 0.944 0 0.328
67

RP11-557H15.3

hsa-let-7a-5p;hsa-let-7c-5p;hsa-let-7d-5p;hsa-let-7f-5p;hsa-let-7g-5p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-20b-5p;hsa-miR-28-5p;hsa-miR-30b-3p 10 CDKN1A Sponge network 1.673 8.0E-5 0.128 0.35863 0.328
68 RP11-524H19.2 hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-191-5p;hsa-miR-218-5p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-340-5p;hsa-miR-374a-3p 10 CDK6 Sponge network 0.759 0.01839 0.944 0 0.326
69 RP11-78C3.1 hsa-miR-101-3p;hsa-miR-140-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-20b-5p;hsa-miR-217;hsa-miR-26a-5p;hsa-miR-30a-3p;hsa-miR-30d-3p;hsa-miR-30e-3p 10 CDK6 Sponge network 5.978 0 0.944 0 0.324
70 RP11-398K22.12 hsa-miR-101-3p;hsa-miR-140-3p;hsa-miR-195-5p;hsa-miR-30a-5p;hsa-miR-30d-5p;hsa-miR-30e-3p;hsa-miR-30e-5p;hsa-miR-335-5p;hsa-miR-340-5p;hsa-miR-378a-3p;hsa-miR-664a-3p 11 CDK6 Sponge network 1.036 0 0.944 0 0.324
71 RP11-25I15.3 hsa-miR-106a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-30a-3p;hsa-miR-30a-5p 11 CDK6 Sponge network 5.655 0 0.944 0 0.323
72 LINC00911 hsa-let-7a-5p;hsa-let-7c-5p;hsa-let-7f-5p;hsa-let-7g-5p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-20b-5p;hsa-miR-28-5p;hsa-miR-491-5p 10 CDKN1A Sponge network 4.956 0 0.128 0.35863 0.323
73

NOP14-AS1

hsa-miR-140-3p;hsa-miR-195-3p;hsa-miR-217;hsa-miR-28-5p;hsa-miR-30a-5p;hsa-miR-30b-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-374a-3p;hsa-miR-378a-3p 10 YWHAZ Sponge network 0.939 0 0.345 0.0016 0.321
74

AF127936.7

hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-141-3p;hsa-miR-148a-5p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-191-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-23b-3p;hsa-miR-26b-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-362-5p;hsa-miR-374a-5p;hsa-miR-378a-3p;hsa-miR-660-5p;hsa-miR-7-1-3p 22 CDK6 Sponge network 0.453 0.00811 0.944 0 0.315
75 CTD-2171N6.1 hsa-miR-101-3p;hsa-miR-140-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-3p;hsa-miR-30d-5p;hsa-miR-30e-3p;hsa-miR-30e-5p;hsa-miR-34a-5p;hsa-miR-497-5p;hsa-miR-502-3p;hsa-miR-582-5p 28 CDK6 Sponge network 5.89 0 0.944 0 0.31
76 LINC00520 hsa-miR-101-3p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-217;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-30a-3p;hsa-miR-335-3p;hsa-miR-374a-5p;hsa-miR-374b-5p;hsa-miR-497-5p 15 CDK6 Sponge network 3.383 0 0.944 0 0.303
77 AC093627.10 hsa-let-7a-3p;hsa-miR-130a-3p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-21-3p;hsa-miR-224-5p;hsa-miR-2355-5p;hsa-miR-27a-3p;hsa-miR-450b-5p;hsa-miR-454-3p 10 SMAD4 Sponge network -0.893 0.00123 -0.43 0 0.301
78 RP11-863P13.3 hsa-miR-140-3p;hsa-miR-148a-5p;hsa-miR-20b-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-27b-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-502-3p 12 CDK6 Sponge network 4.189 0 0.944 0 0.3
79

RP4-794H19.1

hsa-let-7c-5p;hsa-let-7g-5p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-20b-5p;hsa-miR-28-5p;hsa-miR-30b-3p;hsa-miR-345-5p;hsa-miR-363-3p;hsa-miR-491-5p 11 CDKN1A Sponge network 1.019 8.0E-5 0.128 0.35863 0.298
80

MAGI2-AS3

hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-193b-3p;hsa-miR-20a-5p;hsa-miR-2355-3p;hsa-miR-25-3p;hsa-miR-26b-5p;hsa-miR-29b-1-5p;hsa-miR-30c-5p;hsa-miR-339-5p;hsa-miR-342-3p;hsa-miR-582-3p;hsa-miR-590-3p;hsa-miR-92a-3p 14 EP300 Sponge network -0.939 4.0E-5 -0.038 0.77828 0.297
81 RP11-297P16.3 hsa-miR-101-3p;hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-20b-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-340-5p 14 CDK6 Sponge network 6.381 0 0.944 0 0.288
82 CTA-392E5.1 hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-195-5p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-378a-3p 16 CDK6 Sponge network 5.137 0 0.944 0 0.285
83 RP11-879F14.2 hsa-miR-101-3p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-20b-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30e-3p;hsa-miR-378a-3p 14 CDK6 Sponge network 1.149 9.0E-5 0.944 0 0.274
84 RP11-244O19.1 hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-218-5p;hsa-miR-23b-3p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-30d-3p;hsa-miR-30d-5p;hsa-miR-34a-5p;hsa-miR-378a-3p 12 CDK6 Sponge network 0.52 0.05156 0.944 0 0.274
85 CTD-2354A18.1 hsa-miR-101-3p;hsa-miR-140-3p;hsa-miR-195-5p;hsa-miR-217;hsa-miR-26a-5p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30e-3p;hsa-miR-34a-5p;hsa-miR-374a-5p 11 CDK6 Sponge network 4.214 0 0.944 0 0.273
86 RP11-91K9.1 hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-141-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-29c-3p;hsa-miR-9-5p 13 CDK6 Sponge network 3.763 0 0.944 0 0.271
87 RP11-64C12.8 hsa-let-7a-5p;hsa-let-7c-5p;hsa-let-7d-5p;hsa-let-7f-5p;hsa-let-7g-5p;hsa-let-7i-5p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-20b-5p;hsa-miR-28-5p;hsa-miR-30b-3p 11 CDKN1A Sponge network -1.035 0.07653 0.128 0.35863 0.267
88 AC006262.5 hsa-miR-106a-5p;hsa-miR-140-3p;hsa-miR-142-5p;hsa-miR-146a-5p;hsa-miR-148a-5p;hsa-miR-195-5p;hsa-miR-20b-5p;hsa-miR-26a-5p;hsa-miR-30a-3p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-374a-5p;hsa-miR-374b-5p;hsa-miR-378a-3p;hsa-miR-497-5p 15 CDK6 Sponge network 2.376 0 0.944 0 0.261
89

RP11-166D19.1

hsa-let-7a-3p;hsa-miR-130a-3p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-224-5p;hsa-miR-2355-5p;hsa-miR-27a-3p;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-590-5p 10 SMAD4 Sponge network -0.882 5.0E-5 -0.43 0 0.259
90

TPTEP1

hsa-let-7a-3p;hsa-miR-130a-3p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-21-3p;hsa-miR-224-5p;hsa-miR-2355-5p;hsa-miR-27a-3p;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-590-5p 11 SMAD4 Sponge network -2.193 0 -0.43 0 0.257
91

RP11-554I8.2

hsa-let-7c-5p;hsa-let-7g-5p;hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-20b-5p;hsa-miR-28-5p;hsa-miR-30b-3p;hsa-miR-345-5p;hsa-miR-363-3p 10 CDKN1A Sponge network 0.342 0.50007 0.128 0.35863 0.253
92 RP11-356J5.12 hsa-miR-101-3p;hsa-miR-106a-5p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-200b-3p;hsa-miR-20b-5p;hsa-miR-23b-3p;hsa-miR-26a-5p;hsa-miR-27b-3p;hsa-miR-27b-5p;hsa-miR-29c-3p;hsa-miR-30d-3p 13 CDK6 Sponge network 0.472 0.02484 0.944 0 0.253

Quest ID: 3a6e24943d5bd1e4bb20ce669360ab63