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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-148b-3p ZNF555 1.81 0 -0.55 0 mirMAP -0.13 1.0E-5 NA
2 hsa-miR-186-5p ZNF555 1.01 0 -0.55 0 mirMAP -0.13 0.00018 NA
3 hsa-miR-23a-3p ZNF555 1.08 0 -0.55 0 mirMAP -0.13 2.0E-5 NA
4 hsa-miR-30c-5p ZNF555 0.72 1.0E-5 -0.55 0 mirMAP -0.12 1.0E-5 NA
5 hsa-miR-30e-5p ZNF555 0.26 0.04889 -0.55 0 mirMAP -0.13 0.00013 NA
6 hsa-miR-335-3p ZNF555 1.32 0 -0.55 0 mirMAP -0.1 0 NA
7 hsa-miR-454-3p ZNF555 1.53 0 -0.55 0 MirTarget -0.13 0 NA
8 hsa-miR-590-3p ZNF555 1.73 0 -0.55 0 miRanda -0.11 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 18 1977 4.059e-08 0.0001209
2 PROTEIN PHOSPHORYLATION 13 944 5.196e-08 0.0001209
3 RESPONSE TO TYPE I INTERFERON 5 68 3.407e-07 0.0002162
4 CYTOKINE MEDIATED SIGNALING PATHWAY 9 452 4.051e-07 0.0002162
5 RESPONSE TO EXTERNAL STIMULUS 16 1821 5.111e-07 0.0002162
6 INTRACELLULAR SIGNAL TRANSDUCTION 15 1572 4.639e-07 0.0002162
7 CELLULAR RESPONSE TO CYTOKINE STIMULUS 10 606 4.711e-07 0.0002162
8 REGULATION OF MAP KINASE ACTIVITY 8 319 3.424e-07 0.0002162
9 RESPONSE TO BIOTIC STIMULUS 12 886 2.284e-07 0.0002162
10 RESPONSE TO CYTOKINE 11 714 2.253e-07 0.0002162
11 ACTIVATION OF MAPK ACTIVITY 6 137 4.581e-07 0.0002162
12 JNK CASCADE 5 82 8.722e-07 0.0003382
13 PHOSPHORYLATION 13 1228 1.07e-06 0.0003832
14 IMMUNE SYSTEM PROCESS 16 1984 1.617e-06 0.0005375
15 INTERLEUKIN 1 MEDIATED SIGNALING PATHWAY 3 13 2.608e-06 0.0007872
16 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 5 103 2.707e-06 0.0007872
17 PROTEIN AUTOPHOSPHORYLATION 6 192 3.284e-06 0.0008989
18 POSITIVE REGULATION OF MAP KINASE ACTIVITY 6 207 5.065e-06 0.001309
19 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 8 470 6.17e-06 0.001511
20 DEFENSE RESPONSE 12 1231 7.221e-06 0.00168
21 REGULATION OF MAPK CASCADE 9 660 9.07e-06 0.00201
22 DEFENSE RESPONSE TO OTHER ORGANISM 8 505 1.042e-05 0.002203
23 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 7 404 2.242e-05 0.004535
24 DEFENSE RESPONSE TO VIRUS 5 164 2.61e-05 0.00506
25 ACTIVATION OF PROTEIN KINASE ACTIVITY 6 279 2.76e-05 0.005137
26 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 289 3.362e-05 0.006016
27 CELLULAR RESPONSE TO INTERLEUKIN 1 4 88 3.788e-05 0.006527
28 LIPOPOLYSACCHARIDE MEDIATED SIGNALING PATHWAY 3 31 3.99e-05 0.00663
29 INNATE IMMUNE RESPONSE 8 619 4.48e-05 0.007187
30 ACTIVATION OF JUN KINASE ACTIVITY 3 35 5.775e-05 0.008957
31 PEPTIDYL AMINO ACID MODIFICATION 9 841 6.125e-05 0.009193
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 17 992 7.224e-12 6.711e-09
2 PROTEIN KINASE ACTIVITY 13 640 4.944e-10 2.296e-07
3 KINASE ACTIVITY 14 842 1.24e-09 3.839e-07
4 RIBONUCLEOTIDE BINDING 19 1860 2.069e-09 4.806e-07
5 PROTEIN SERINE THREONINE KINASE ACTIVITY 10 445 2.673e-08 4.966e-06
6 ADENYL NUCLEOTIDE BINDING 16 1514 3.999e-08 6.192e-06
7 RECEPTOR SIGNALING PROTEIN SERINE THREONINE KINASE ACTIVITY 5 92 1.547e-06 0.0002054
8 ADENYLYLTRANSFERASE ACTIVITY 3 24 1.816e-05 0.002108
9 RECEPTOR SIGNALING PROTEIN ACTIVITY 5 172 3.279e-05 0.003385
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04270_Vascular_smooth_muscle_contraction 3 116 0.001981 0.1548
2 hsa04722_Neurotrophin_signaling_pathway 3 127 0.002564 0.1548
3 hsa04010_MAPK_signaling_pathway 4 268 0.002581 0.1548
4 hsa00230_Purine_metabolism 3 162 0.005077 0.2285
5 hsa04810_Regulation_of_actin_cytoskeleton 3 214 0.01088 0.3918
6 hsa04210_Apoptosis 2 89 0.01571 0.4713
7 hsa04620_Toll.like_receptor_signaling_pathway 2 102 0.0203 0.5221
8 hsa04380_Osteoclast_differentiation 2 128 0.03094 0.6366
9 hsa04360_Axon_guidance 2 130 0.03183 0.6366
10 hsa04151_PI3K_AKT_signaling_pathway 3 351 0.03947 0.7104
11 hsa04062_Chemokine_signaling_pathway 2 189 0.06232 0.8471
12 hsa04510_Focal_adhesion 2 200 0.06879 0.8471
13 hsa04144_Endocytosis 2 203 0.07059 0.8471
14 hsa04014_Ras_signaling_pathway 2 236 0.09139 0.8658

Quest ID: 3aea1a4f6e8bbfbd7cdd09a4df8a0504