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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-106b-5p APC -0.3 0.86929 0.2 0.85295 miRNAWalker2 validate; miRTarBase -0.22 0 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells
2 hsa-miR-148a-3p APC -0.1 0.97698 0.2 0.85295 miRNAWalker2 validate -0.12 0.00641 NA
3 hsa-miR-154-3p APC -0.17 0.5465 0.2 0.85295 TargetScan -0.12 0.00356 NA
4 hsa-miR-192-5p APC -0.12 0.97293 0.2 0.85295 miRNAWalker2 validate -0.11 0.00054 NA
5 hsa-miR-193a-3p APC -0.25 0.65436 0.2 0.85295 miRanda -0.15 0.00011 NA
6 hsa-miR-27a-3p APC -0.12 0.9588 0.2 0.85295 miRNAWalker2 validate; miRTarBase; miRNATAP -0.17 0.00984 22018270 Finally the APC gene was identified as the direct and functional target of miR-27
7 hsa-miR-335-3p APC -0.24 0.8845 0.2 0.85295 mirMAP -0.21 0 NA
8 hsa-miR-374a-5p APC -0.34 0.76692 0.2 0.85295 mirMAP -0.28 0 NA
9 hsa-miR-374b-5p APC -0.29 0.8357 0.2 0.85295 mirMAP -0.2 0.00044 NA
10 hsa-miR-421 APC -0.18 0.7347 0.2 0.85295 miRanda -0.15 0.0002 NA
11 hsa-miR-450b-5p APC -0.01 0.98315 0.2 0.85295 miRNATAP -0.17 6.0E-5 NA
12 hsa-miR-501-3p APC -0.75 0.55276 0.2 0.85295 TargetScan -0.12 0.00171 NA
13 hsa-miR-590-3p APC -0.28 0.59127 0.2 0.85295 PITA; miRanda; mirMAP; miRNATAP -0.1 0.00339 NA
14 hsa-miR-20a-3p APC2 0.46 0.57674 -0.38 0.36375 mirMAP -0.17 0.00956 NA
15 hsa-miR-452-3p APC2 -0.17 0.79901 -0.38 0.36375 mirMAP -0.17 0.00953 NA
16 hsa-miR-582-5p AXIN2 -0.4 0.58123 0.16 0.92249 miRNATAP -0.54 0 NA
17 hsa-miR-195-3p CACYBP 0.12 0.69192 0.04 0.97693 mirMAP -0.15 0 NA
18 hsa-miR-30a-3p CACYBP 0.25 0.91709 0.04 0.97693 MirTarget -0.23 0 NA
19 hsa-miR-186-5p CAMK2B -0.32 0.85413 2.17 0.00982 miRNAWalker2 validate; miRNATAP -0.92 0 NA
20 hsa-miR-18a-5p CAMK2B -0.5 0.61264 2.17 0.00982 mirMAP -0.33 0.00078 NA
21 hsa-miR-362-3p CAMK2B -0.72 0.03459 2.17 0.00982 miRanda -0.39 0.00026 NA
22 hsa-miR-362-5p CAMK2B -0.27 0.75202 2.17 0.00982 miRNATAP -0.43 3.0E-5 NA
23 hsa-miR-577 CAMK2B -1.06 0.32606 2.17 0.00982 miRNATAP -0.33 0 NA
24 hsa-miR-589-3p CAMK2B -0.84 0.0112 2.17 0.00982 MirTarget -0.47 0 NA
25 hsa-miR-590-3p CAMK2B -0.28 0.59127 2.17 0.00982 miRanda -0.42 0.00016 NA
26 hsa-miR-625-5p CAMK2B -0.69 0.21031 2.17 0.00982 mirMAP -0.4 3.0E-5 NA
27 hsa-miR-628-5p CAMK2B -0.51 0.35193 2.17 0.00982 miRNATAP -0.53 0.00189 NA
28 hsa-miR-940 CAMK2B -0.23 0.68006 2.17 0.00982 PITA; miRNATAP -0.25 0.0094 NA
29 hsa-miR-708-3p CAMK2D 0.14 0.89698 -0.33 0.80466 mirMAP -0.14 0.00023 NA
30 hsa-miR-181a-5p CAMK2G 0.03 0.98933 0.21 0.86839 miRNATAP -0.1 0.00195 NA
31 hsa-miR-181b-5p CAMK2G 0.16 0.93018 0.21 0.86839 miRNATAP -0.1 0.00173 NA
32 hsa-miR-628-5p CAMK2G -0.51 0.35193 0.21 0.86839 MirTarget; PITA; miRNATAP -0.17 0 NA
33 hsa-miR-16-5p CCND1 0.01 0.99448 -0.25 0.89067 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.13 0.00823 23991964; 22922827; 18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL
34 hsa-miR-195-5p CCND1 0.34 0.74962 -0.25 0.89067 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.14 0.00272 21350001; 26631043; 25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma
35 hsa-miR-29c-3p CCND1 0.16 0.94272 -0.25 0.89067 mirMAP -0.14 0.00181 NA
36 hsa-miR-24-3p CHD8 -0.05 0.98527 -0.23 0.87207 miRNAWalker2 validate -0.17 0.00183 NA
37 hsa-miR-493-5p CREBBP 0.23 0.73198 -0.07 0.96314 miRNATAP -0.13 0.00036 NA
38 hsa-miR-30e-5p CSNK1A1 -0.07 0.97968 0.04 0.98107 MirTarget -0.11 0.00277 NA
39 hsa-miR-146b-5p CSNK2A2 -0.4 0.83751 0.05 0.96212 miRanda -0.17 0 NA
40 hsa-miR-212-3p CSNK2A2 -0.02 0.97323 0.05 0.96212 mirMAP -0.12 0.00416 NA
41 hsa-miR-92b-3p CSNK2A2 -0.57 0.68932 0.05 0.96212 mirMAP -0.11 0.00058 NA
42 hsa-miR-140-5p CTNNB1 -0.23 0.84733 -0.27 0.89738 miRanda -0.14 0.00185 NA
43 hsa-let-7f-1-3p CXXC4 -0.31 0.69341 0.79 0.21218 mirMAP -0.52 0.00404 NA
44 hsa-miR-126-5p CXXC4 0.08 0.95664 0.79 0.21218 MirTarget; mirMAP -0.43 0.00513 NA
45 hsa-miR-146b-5p CXXC4 -0.4 0.83751 0.79 0.21218 MirTarget; miRNATAP -0.66 0 NA
46 hsa-miR-223-3p CXXC4 -0.45 0.80968 0.79 0.21218 MirTarget -0.33 9.0E-5 NA
47 hsa-miR-338-5p CXXC4 0.48 0.39396 0.79 0.21218 MirTarget; miRNATAP -0.3 0.00058 NA
48 hsa-miR-576-5p CXXC4 -0.51 0.41719 0.79 0.21218 mirMAP -0.32 0.00846 NA
49 hsa-miR-582-5p CXXC4 -0.4 0.58123 0.79 0.21218 MirTarget; miRNATAP -0.4 0.00183 NA
50 hsa-miR-589-5p CXXC4 -0.45 0.72273 0.79 0.21218 MirTarget; miRNATAP -0.63 0.00012 NA
51 hsa-miR-7-1-3p CXXC4 -0.46 0.6659 0.79 0.21218 mirMAP -0.36 0.00207 NA
52 hsa-let-7a-3p DAAM1 -0.22 0.85543 -0.17 0.85781 MirTarget -0.14 0.00396 NA
53 hsa-let-7g-3p DAAM1 -0.49 0.62942 -0.17 0.85781 MirTarget -0.12 0.00136 NA
54 hsa-miR-125a-5p DAAM1 -0 0.99916 -0.17 0.85781 MirTarget -0.15 0.00828 NA
55 hsa-miR-130a-3p DAAM1 0.09 0.9291 -0.17 0.85781 MirTarget; miRNATAP -0.19 5.0E-5 NA
56 hsa-miR-130b-3p DAAM1 -0.22 0.82466 -0.17 0.85781 MirTarget; miRNATAP -0.19 3.0E-5 NA
57 hsa-miR-130b-5p DAAM1 -0.65 0.3791 -0.17 0.85781 MirTarget -0.13 0.00225 NA
58 hsa-miR-140-5p DAAM1 -0.23 0.84733 -0.17 0.85781 miRanda -0.2 0.00199 NA
59 hsa-miR-142-3p DAAM1 -0.15 0.9461 -0.17 0.85781 miRanda -0.11 0.00177 NA
60 hsa-miR-186-5p DAAM1 -0.32 0.85413 -0.17 0.85781 MirTarget; mirMAP -0.2 0.00143 NA
61 hsa-miR-19a-3p DAAM1 -0.21 0.84464 -0.17 0.85781 miRNATAP -0.16 2.0E-5 NA
62 hsa-miR-19b-3p DAAM1 -0.03 0.98666 -0.17 0.85781 miRNATAP -0.22 0 NA
63 hsa-miR-27a-3p DAAM1 -0.12 0.9588 -0.17 0.85781 miRNATAP -0.32 0 NA
64 hsa-miR-29a-3p DAAM1 0.01 0.99698 -0.17 0.85781 MirTarget; miRNATAP -0.31 0 NA
65 hsa-miR-29b-3p DAAM1 -0.1 0.95899 -0.17 0.85781 MirTarget; miRNATAP -0.21 0 NA
66 hsa-miR-32-3p DAAM1 -0.57 0.13133 -0.17 0.85781 mirMAP -0.12 0.00012 NA
67 hsa-miR-32-5p DAAM1 -0.06 0.95298 -0.17 0.85781 miRNATAP -0.14 0.00133 NA
68 hsa-miR-335-5p DAAM1 -0.03 0.97338 -0.17 0.85781 miRNAWalker2 validate; MirTarget; miRNATAP -0.16 9.0E-5 NA
69 hsa-miR-362-3p DAAM1 -0.72 0.03459 -0.17 0.85781 MirTarget; miRanda; miRNATAP -0.16 1.0E-5 NA
70 hsa-miR-429 DAAM1 -0.46 0.80624 -0.17 0.85781 miRNATAP -0.1 0.00409 NA
71 hsa-miR-452-5p DAAM1 -0.05 0.97387 -0.17 0.85781 MirTarget -0.16 0.00025 NA
72 hsa-miR-454-3p DAAM1 -0.1 0.84355 -0.17 0.85781 MirTarget; miRNATAP -0.17 0.00176 NA
73 hsa-miR-548o-3p DAAM1 -0.19 0.51773 -0.17 0.85781 mirMAP -0.11 0.00528 NA
74 hsa-miR-590-3p DAAM1 -0.28 0.59127 -0.17 0.85781 MirTarget; miRanda; mirMAP -0.13 0.00054 NA
75 hsa-miR-92a-3p DAAM1 0.03 0.99325 -0.17 0.85781 miRNATAP -0.19 2.0E-5 NA
76 hsa-miR-141-5p DAAM2 -0.35 0.86764 0.12 0.86624 mirMAP -0.6 0 NA
77 hsa-miR-182-5p DAAM2 -0.1 0.97338 0.12 0.86624 mirMAP -0.36 0 NA
78 hsa-miR-18a-5p DAAM2 -0.5 0.61264 0.12 0.86624 miRNAWalker2 validate -0.46 0 NA
79 hsa-miR-193a-3p DAAM2 -0.25 0.65436 0.12 0.86624 miRanda -0.34 2.0E-5 NA
80 hsa-miR-1976 DAAM2 -0.28 0.707 0.12 0.86624 mirMAP -0.53 0 NA
81 hsa-miR-19b-3p DAAM2 -0.03 0.98666 0.12 0.86624 miRNAWalker2 validate -0.59 0 NA
82 hsa-miR-335-5p DAAM2 -0.03 0.97338 0.12 0.86624 mirMAP -0.56 0 NA
83 hsa-miR-339-5p DAAM2 -0.3 0.71291 0.12 0.86624 miRanda -0.55 0 NA
84 hsa-miR-361-3p DAAM2 -0.29 0.84773 0.12 0.86624 mirMAP -0.33 0.00993 NA
85 hsa-miR-369-3p DAAM2 0.12 0.8323 0.12 0.86624 mirMAP -0.27 0.00212 NA
86 hsa-miR-421 DAAM2 -0.18 0.7347 0.12 0.86624 PITA; miRanda -0.35 1.0E-5 NA
87 hsa-miR-429 DAAM2 -0.46 0.80624 0.12 0.86624 miRNATAP -0.55 0 NA
88 hsa-miR-589-3p DAAM2 -0.84 0.0112 0.12 0.86624 mirMAP -0.35 0 NA
89 hsa-miR-590-3p DAAM2 -0.28 0.59127 0.12 0.86624 miRanda; mirMAP -0.58 0 NA
90 hsa-miR-592 DAAM2 -0.18 0.85623 0.12 0.86624 mirMAP -0.12 0.00127 NA
91 hsa-miR-107 DKK1 -0.04 0.98836 2.12 0.01001 miRanda -1.07 0.00153 NA
92 hsa-miR-16-2-3p DKK1 -0.37 0.54685 2.12 0.01001 mirMAP -0.73 7.0E-5 NA
93 hsa-miR-590-3p DKK1 -0.28 0.59127 2.12 0.01001 PITA; miRanda; mirMAP; miRNATAP -0.61 0.00025 NA
94 hsa-miR-142-3p DKK2 -0.15 0.9461 0.67 0.21846 miRanda -0.29 0.00978 NA
95 hsa-miR-193a-3p DKK2 -0.25 0.65436 0.67 0.21846 miRanda -0.34 0.00831 NA
96 hsa-miR-221-3p DKK2 0.09 0.95912 0.67 0.21846 miRNAWalker2 validate; miRTarBase -0.89 0 NA
97 hsa-miR-27a-3p DKK2 -0.12 0.9588 0.67 0.21846 miRNATAP -0.74 0.00065 NA
98 hsa-miR-324-5p DKK2 -0.5 0.53742 0.67 0.21846 miRanda -0.69 0 NA
99 hsa-miR-335-5p DKK2 -0.03 0.97338 0.67 0.21846 miRNAWalker2 validate -0.74 0 NA
100 hsa-miR-33a-3p DKK2 -0.79 0.01052 0.67 0.21846 mirMAP -0.52 1.0E-5 NA
101 hsa-miR-361-5p DKK2 -0.14 0.9415 0.67 0.21846 miRanda -0.99 1.0E-5 NA
102 hsa-miR-374a-5p DKK2 -0.34 0.76692 0.67 0.21846 mirMAP -0.61 0.00163 NA
103 hsa-miR-374b-5p DKK2 -0.29 0.8357 0.67 0.21846 mirMAP -0.9 0 NA
104 hsa-miR-486-5p DKK2 -0.55 0.6964 0.67 0.21846 miRanda; miRNATAP -0.39 1.0E-5 NA
105 hsa-miR-576-5p DKK2 -0.51 0.41719 0.67 0.21846 mirMAP -0.82 0 NA
106 hsa-miR-590-3p DKK2 -0.28 0.59127 0.67 0.21846 miRanda; mirMAP; miRNATAP -0.76 0 NA
107 hsa-miR-590-5p DKK2 -0.55 0.47274 0.67 0.21846 miRanda -0.77 0 NA
108 hsa-miR-221-3p DVL2 0.09 0.95912 -0.17 0.88279 miRNAWalker2 validate -0.11 0.0034 21487968 MiR 221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2; We also suggest that miR-221 may control the migration of AIPC cells through DVL2 working as a key regulator in advanced CaP
109 hsa-miR-21-5p DVL3 -0.15 0.97024 0.02 0.98794 mirMAP -0.13 0.00029 NA
110 hsa-miR-106b-5p EP300 -0.3 0.86929 -0.28 0.85828 miRNATAP -0.13 0.00096 NA
111 hsa-miR-26b-5p EP300 -0.02 0.99038 -0.28 0.85828 miRNAWalker2 validate; miRNATAP -0.12 0.00816 NA
112 hsa-miR-339-5p EP300 -0.3 0.71291 -0.28 0.85828 miRanda -0.11 0.00013 NA
113 hsa-miR-369-3p EP300 0.12 0.8323 -0.28 0.85828 MirTarget; PITA; miRNATAP -0.15 1.0E-5 NA
114 hsa-miR-374a-5p FBXW11 -0.34 0.76692 0.06 0.96203 mirMAP -0.12 0.00016 NA
115 hsa-miR-505-3p FBXW11 -0.47 0.69038 0.06 0.96203 mirMAP -0.1 0.00011 NA
116 hsa-miR-22-3p FRAT2 0.06 0.98656 -0.19 0.86974 miRNAWalker2 validate; MirTarget; miRNATAP -0.19 0.00288 NA
117 hsa-miR-1275 FZD1 -0.83 0.08038 -0.05 0.95908 MirTarget -0.12 0.00038 NA
118 hsa-miR-146a-5p FZD1 -0.58 0.73685 -0.05 0.95908 MirTarget -0.18 3.0E-5 NA
119 hsa-miR-148b-5p FZD1 -0.24 0.43926 -0.05 0.95908 MirTarget -0.28 0 NA
120 hsa-miR-186-5p FZD1 -0.32 0.85413 -0.05 0.95908 mirMAP -0.44 0 NA
121 hsa-miR-192-5p FZD1 -0.12 0.97293 -0.05 0.95908 miRNAWalker2 validate -0.29 0 NA
122 hsa-miR-200a-5p FZD1 -0.67 0.78126 -0.05 0.95908 MirTarget -0.28 0 NA
123 hsa-miR-200b-5p FZD1 -0.5 0.72226 -0.05 0.95908 MirTarget -0.34 0 NA
124 hsa-miR-29a-3p FZD1 0.01 0.99698 -0.05 0.95908 mirMAP -0.41 0 NA
125 hsa-miR-29b-3p FZD1 -0.1 0.95899 -0.05 0.95908 mirMAP -0.39 0 NA
126 hsa-miR-335-5p FZD1 -0.03 0.97338 -0.05 0.95908 miRNAWalker2 validate -0.29 0 NA
127 hsa-miR-577 FZD1 -1.06 0.32606 -0.05 0.95908 MirTarget; PITA -0.19 0 NA
128 hsa-miR-590-3p FZD1 -0.28 0.59127 -0.05 0.95908 miRanda -0.29 0 NA
129 hsa-miR-93-3p FZD1 -0.44 0.5499 -0.05 0.95908 MirTarget -0.33 0 NA
130 hsa-miR-140-3p FZD10 -0.37 0.86476 0.67 0.34352 miRNATAP -0.87 0.00824 NA
131 hsa-miR-15b-5p FZD10 -0.27 0.87097 0.67 0.34352 miRNATAP -0.76 0.00034 NA
132 hsa-miR-16-5p FZD10 0.01 0.99448 0.67 0.34352 miRNATAP -0.66 0.00183 NA
133 hsa-miR-92b-3p FZD10 -0.57 0.68932 0.67 0.34352 miRNATAP -0.85 0 NA
134 hsa-miR-30a-3p FZD3 0.25 0.91709 -0.71 0.30817 mirMAP -0.5 0 NA
135 hsa-miR-30a-5p FZD3 0.22 0.93395 -0.71 0.30817 MirTarget; miRNATAP -0.73 0 NA
136 hsa-miR-30e-5p FZD3 -0.07 0.97968 -0.71 0.30817 MirTarget -0.31 0.00776 NA
137 hsa-let-7a-3p FZD4 -0.22 0.85543 0.09 0.9264 mirMAP -0.24 2.0E-5 NA
138 hsa-let-7d-5p FZD4 -0.14 0.93416 0.09 0.9264 MirTarget; miRNATAP -0.38 1.0E-5 NA
139 hsa-let-7f-1-3p FZD4 -0.31 0.69341 0.09 0.9264 mirMAP -0.33 2.0E-5 NA
140 hsa-let-7f-5p FZD4 0.05 0.98728 0.09 0.9264 MirTarget; miRNATAP -0.24 0.00274 NA
141 hsa-let-7g-3p FZD4 -0.49 0.62942 0.09 0.9264 MirTarget; miRNATAP -0.25 0 NA
142 hsa-let-7g-5p FZD4 -0.2 0.92299 0.09 0.9264 MirTarget; miRNATAP -0.45 0 NA
143 hsa-miR-106b-5p FZD4 -0.3 0.86929 0.09 0.9264 miRNATAP -0.46 0 NA
144 hsa-miR-107 FZD4 -0.04 0.98836 0.09 0.9264 miRNATAP -0.29 0.00077 NA
145 hsa-miR-10a-5p FZD4 0.07 0.98377 0.09 0.9264 MirTarget -0.28 0 NA
146 hsa-miR-130b-3p FZD4 -0.22 0.82466 0.09 0.9264 mirMAP -0.41 0 NA
147 hsa-miR-141-3p FZD4 -0.32 0.87774 0.09 0.9264 TargetScan -0.35 0 NA
148 hsa-miR-15a-5p FZD4 -0.07 0.96484 0.09 0.9264 MirTarget -0.4 0 NA
149 hsa-miR-15b-5p FZD4 -0.27 0.87097 0.09 0.9264 MirTarget -0.32 0 NA
150 hsa-miR-16-5p FZD4 0.01 0.99448 0.09 0.9264 MirTarget -0.39 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 WNT SIGNALING PATHWAY 61 351 7.448e-87 3.466e-83
2 CANONICAL WNT SIGNALING PATHWAY 32 95 2.5e-53 5.817e-50
3 REGULATION OF WNT SIGNALING PATHWAY 38 310 2.92e-45 4.528e-42
4 NON CANONICAL WNT SIGNALING PATHWAY 31 140 4.233e-45 4.924e-42
5 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 31 197 4.281e-40 3.984e-37
6 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 46 1021 1.634e-35 1.267e-32
7 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 28 236 1.637e-32 1.088e-29
8 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 25 162 5.603e-32 3.259e-29
9 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 50 1672 1.41e-30 7.292e-28
10 REGULATION OF ORGAN MORPHOGENESIS 26 242 5.324e-29 2.477e-26
11 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 16 39 2.399e-28 1.015e-25
12 NEGATIVE REGULATION OF CELL COMMUNICATION 41 1192 1.351e-26 5.239e-24
13 POSITIVE REGULATION OF RESPONSE TO STIMULUS 48 1929 1.505e-25 5.388e-23
14 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 42 1360 1.763e-25 5.861e-23
15 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 18 110 1.357e-23 4.21e-21
16 POSITIVE REGULATION OF CELL COMMUNICATION 42 1532 1.827e-23 5.314e-21
17 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 29 554 2.262e-23 6.191e-21
18 REGULATION OF CELL DIFFERENTIATION 41 1492 7.178e-23 1.856e-20
19 TISSUE DEVELOPMENT 41 1518 1.376e-22 3.37e-20
20 POSITIVE REGULATION OF GENE EXPRESSION 43 1733 2.14e-22 4.979e-20
21 EPITHELIUM DEVELOPMENT 34 945 2.679e-22 5.936e-20
22 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 40 1492 7.518e-22 1.59e-19
23 REGULATION OF EMBRYONIC DEVELOPMENT 17 114 1.357e-21 2.744e-19
24 TUBE MORPHOGENESIS 23 323 1.661e-21 3.221e-19
25 TISSUE MORPHOGENESIS 27 533 2.351e-21 4.376e-19
26 TUBE DEVELOPMENT 27 552 5.841e-21 1.045e-18
27 MORPHOGENESIS OF AN EPITHELIUM 24 400 1.11e-20 1.913e-18
28 PATTERN SPECIFICATION PROCESS 24 418 3.107e-20 5.163e-18
29 EMBRYO DEVELOPMENT 31 894 9.121e-20 1.463e-17
30 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 34 1142 1.058e-19 1.588e-17
31 REGULATION OF PROTEIN MODIFICATION PROCESS 40 1710 1.058e-19 1.588e-17
32 ORGAN MORPHOGENESIS 30 841 1.898e-19 2.76e-17
33 CARDIOVASCULAR SYSTEM DEVELOPMENT 29 788 3.801e-19 5.202e-17
34 CIRCULATORY SYSTEM DEVELOPMENT 29 788 3.801e-19 5.202e-17
35 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 40 1805 7.319e-19 9.66e-17
36 NEUROGENESIS 36 1402 7.681e-19 9.66e-17
37 EMBRYONIC MORPHOGENESIS 25 539 7.63e-19 9.66e-17
38 BETA CATENIN DESTRUCTION COMPLEX DISASSEMBLY 10 22 1.258e-18 1.5e-16
39 POSITIVE REGULATION OF CELL DIFFERENTIATION 29 823 1.231e-18 1.5e-16
40 NEURON DIFFERENTIATION 29 874 6.201e-18 7.213e-16
41 REGIONALIZATION 20 311 7.083e-18 8.039e-16
42 REGULATION OF PHOSPHORUS METABOLIC PROCESS 37 1618 9.645e-18 1.069e-15
43 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 37 1656 2.067e-17 2.237e-15
44 INTRACELLULAR SIGNAL TRANSDUCTION 36 1572 3.073e-17 3.25e-15
45 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 34 1395 5.023e-17 5.193e-15
46 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 27 801 7.608e-17 7.696e-15
47 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 31 1135 8.098e-17 8.017e-15
48 HEART DEVELOPMENT 22 466 9.125e-17 8.845e-15
49 NEURAL TUBE DEVELOPMENT 15 149 1.673e-16 1.588e-14
50 CELL FATE COMMITMENT 17 227 2.115e-16 1.968e-14
51 REGULATION OF CELLULAR PROTEIN LOCALIZATION 23 552 2.478e-16 2.261e-14
52 POSITIVE REGULATION OF MOLECULAR FUNCTION 37 1791 2.65e-16 2.371e-14
53 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 29 1036 5.613e-16 4.837e-14
54 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 29 1036 5.613e-16 4.837e-14
55 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 19 337 5.914e-16 5.003e-14
56 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 28 957 6.68e-16 5.55e-14
57 MORPHOGENESIS OF EMBRYONIC EPITHELIUM 14 134 1.077e-15 8.79e-14
58 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 36 1784 1.674e-15 1.343e-13
59 REGULATION OF CELLULAR RESPONSE TO STRESS 24 691 2.904e-15 2.29e-13
60 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 36 1848 5.017e-15 3.891e-13
61 SEGMENTATION 12 89 5.776e-15 4.406e-13
62 ANTERIOR POSTERIOR PATTERN SPECIFICATION 15 194 8.887e-15 6.669e-13
63 NEURAL TUBE FORMATION 12 94 1.141e-14 8.429e-13
64 DORSAL VENTRAL AXIS SPECIFICATION 8 20 1.474e-14 1.072e-12
65 TUBE FORMATION 13 129 1.947e-14 1.394e-12
66 CELL DEVELOPMENT 31 1426 4.307e-14 3.036e-12
67 REGULATION OF PROTEIN LOCALIZATION 26 950 4.45e-14 3.09e-12
68 SOMITE DEVELOPMENT 11 78 4.959e-14 3.393e-12
69 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 15 220 5.717e-14 3.855e-12
70 REGULATION OF PROTEIN IMPORT 14 183 8.607e-14 5.721e-12
71 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY INVOLVED IN NEURAL TUBE CLOSURE 7 14 9.853e-14 6.367e-12
72 CONVERGENT EXTENSION 7 14 9.853e-14 6.367e-12
73 REGULATION OF CELL DEATH 31 1472 1.011e-13 6.446e-12
74 REGULATION OF BINDING 16 283 1.42e-13 8.926e-12
75 CELLULAR RESPONSE TO LIPID 19 457 1.466e-13 9.098e-12
76 REGULATION OF CELL PROLIFERATION 31 1496 1.559e-13 9.546e-12
77 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 26 1004 1.604e-13 9.691e-12
78 SOMITOGENESIS 10 62 1.807e-13 1.064e-11
79 NEGATIVE REGULATION OF EMBRYONIC DEVELOPMENT 8 26 1.788e-13 1.064e-11
80 REGULATION OF CELL DEVELOPMENT 24 836 1.874e-13 1.09e-11
81 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 31 1517 2.262e-13 1.299e-11
82 EMBRYONIC ORGAN DEVELOPMENT 18 406 2.346e-13 1.331e-11
83 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 14 197 2.385e-13 1.337e-11
84 BETA CATENIN TCF COMPLEX ASSEMBLY 9 43 2.497e-13 1.383e-11
85 MIDBRAIN DEVELOPMENT 11 90 2.539e-13 1.39e-11
86 CELLULAR RESPONSE TO RETINOIC ACID 10 65 2.976e-13 1.599e-11
87 REGULATION OF JNK CASCADE 13 159 2.99e-13 1.599e-11
88 REGULATION OF CELL MORPHOGENESIS 20 552 3.963e-13 2.095e-11
89 REGULATION OF PROTEIN TARGETING 16 307 4.966e-13 2.596e-11
90 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 27 1152 5.212e-13 2.694e-11
91 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 17 365 5.309e-13 2.715e-11
92 SENSORY ORGAN DEVELOPMENT 19 493 5.628e-13 2.846e-11
93 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 23 799 6.253e-13 3.115e-11
94 REGULATION OF RESPONSE TO STRESS 30 1468 6.292e-13 3.115e-11
95 REGULATION OF TRANSPORT 33 1804 6.386e-13 3.128e-11
96 DIGESTIVE TRACT MORPHOGENESIS 9 48 7.293e-13 3.535e-11
97 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 25 983 7.842e-13 3.762e-11
98 REGULATION OF CELLULAR LOCALIZATION 28 1277 8.67e-13 4.116e-11
99 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 14 218 9.57e-13 4.498e-11
100 NEGATIVE REGULATION OF GENE EXPRESSION 30 1493 9.71e-13 4.518e-11
101 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 17 381 1.058e-12 4.874e-11
102 REGULATION OF MAPK CASCADE 21 660 1.137e-12 5.134e-11
103 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 19 513 1.134e-12 5.134e-11
104 POSITIVE REGULATION OF CATALYTIC ACTIVITY 30 1518 1.485e-12 6.645e-11
105 CELL PROLIFERATION 21 672 1.602e-12 7.101e-11
106 RESPONSE TO RETINOIC ACID 11 107 1.778e-12 7.803e-11
107 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 18 470 2.761e-12 1.2e-10
108 REGULATION OF CELL CYCLE 24 949 2.816e-12 1.213e-10
109 REGULATION OF JUN KINASE ACTIVITY 10 81 2.946e-12 1.258e-10
110 EPITHELIAL TO MESENCHYMAL TRANSITION 9 56 3.2e-12 1.353e-10
111 REGULATION OF STEM CELL DIFFERENTIATION 11 113 3.263e-12 1.368e-10
112 REGULATION OF INTRACELLULAR TRANSPORT 20 621 3.432e-12 1.426e-10
113 REGULATION OF CYTOPLASMIC TRANSPORT 18 481 4.06e-12 1.672e-10
114 HEAD DEVELOPMENT 21 709 4.429e-12 1.808e-10
115 GASTRULATION 12 155 4.971e-12 2.011e-10
116 RESPONSE TO LIPID 23 888 5.447e-12 2.185e-10
117 RESPONSE TO OXYGEN CONTAINING COMPOUND 28 1381 5.702e-12 2.268e-10
118 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 12 162 8.396e-12 3.311e-10
119 AXIS SPECIFICATION 10 90 8.682e-12 3.395e-10
120 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 15 323 1.474e-11 5.716e-10
121 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 9 67 1.735e-11 6.67e-10
122 PROTEIN PHOSPHORYLATION 23 944 1.876e-11 7.154e-10
123 POSITIVE REGULATION OF CELL DEATH 19 605 1.996e-11 7.552e-10
124 NEGATIVE REGULATION OF CELL DIFFERENTIATION 19 609 2.236e-11 8.39e-10
125 EMBRYONIC ORGAN MORPHOGENESIS 14 279 2.675e-11 9.957e-10
126 CENTRAL NERVOUS SYSTEM DEVELOPMENT 22 872 2.878e-11 1.063e-09
127 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 22 876 3.144e-11 1.152e-09
128 REPRODUCTIVE SYSTEM DEVELOPMENT 16 408 3.636e-11 1.322e-09
129 NEGATIVE REGULATION OF MOLECULAR FUNCTION 24 1079 4.132e-11 1.49e-09
130 SENSORY ORGAN MORPHOGENESIS 13 239 5.322e-11 1.905e-09
131 MESENCHYME DEVELOPMENT 12 190 5.472e-11 1.929e-09
132 STEM CELL DIFFERENTIATION 12 190 5.472e-11 1.929e-09
133 DIGESTIVE SYSTEM DEVELOPMENT 11 148 6.314e-11 2.209e-09
134 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 11 152 8.43e-11 2.927e-09
135 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 20 750 1.014e-10 3.495e-09
136 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 10 117 1.227e-10 4.197e-09
137 INOSITOL PHOSPHATE MEDIATED SIGNALING 6 18 1.246e-10 4.232e-09
138 REGULATION OF TRANSFERASE ACTIVITY 22 946 1.373e-10 4.63e-09
139 BRAIN MORPHOGENESIS 7 34 1.436e-10 4.807e-09
140 REGULATION OF MAP KINASE ACTIVITY 14 319 1.577e-10 5.242e-09
141 REGULATION OF KINASE ACTIVITY 20 776 1.849e-10 6.101e-09
142 HEART MORPHOGENESIS 12 212 1.953e-10 6.401e-09
143 NEGATIVE REGULATION OF CELL DEATH 21 872 2.074e-10 6.749e-09
144 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 31 1977 2.142e-10 6.922e-09
145 REGULATION OF PROTEIN BINDING 11 168 2.479e-10 7.956e-09
146 REGULATION OF ORGANELLE ORGANIZATION 24 1178 2.496e-10 7.956e-09
147 VASCULATURE DEVELOPMENT 16 469 2.832e-10 8.964e-09
148 DORSAL VENTRAL PATTERN FORMATION 9 91 2.913e-10 9.157e-09
149 POSITIVE REGULATION OF CELL DEVELOPMENT 16 472 3.108e-10 9.706e-09
150 RESPONSE TO GROWTH FACTOR 16 475 3.409e-10 1.057e-08
151 CELLULAR RESPONSE TO ACID CHEMICAL 11 175 3.839e-10 1.183e-08
152 POSITIVE REGULATION OF JUN KINASE ACTIVITY 8 63 3.873e-10 1.186e-08
153 REGULATION OF CELL CYCLE PROCESS 17 558 4.187e-10 1.273e-08
154 MESENCHYMAL CELL DIFFERENTIATION 10 134 4.713e-10 1.424e-08
155 REGULATION OF HYDROLASE ACTIVITY 25 1327 4.958e-10 1.488e-08
156 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 10 135 5.071e-10 1.513e-08
157 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 13 289 5.566e-10 1.65e-08
158 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 19 740 6.051e-10 1.782e-08
159 FC EPSILON RECEPTOR SIGNALING PATHWAY 10 142 8.338e-10 2.44e-08
160 RESPIRATORY SYSTEM DEVELOPMENT 11 197 1.352e-09 3.932e-08
161 CELL CYCLE PROCESS 22 1081 1.685e-09 4.869e-08
162 SKELETAL SYSTEM DEVELOPMENT 15 455 1.731e-09 4.971e-08
163 RESPONSE TO ACID CHEMICAL 13 319 1.851e-09 5.285e-08
164 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 17 616 1.876e-09 5.323e-08
165 REGULATION OF CATENIN IMPORT INTO NUCLEUS 6 27 1.924e-09 5.392e-08
166 AXIS ELONGATION 6 27 1.924e-09 5.392e-08
167 CELLULAR COMPONENT MORPHOGENESIS 20 900 2.418e-09 6.738e-08
168 DOPAMINERGIC NEURON DIFFERENTIATION 6 28 2.439e-09 6.756e-08
169 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 7 50 2.516e-09 6.926e-08
170 POSITIVE REGULATION OF MAPK CASCADE 15 470 2.688e-09 7.358e-08
171 POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 9 119 3.245e-09 8.803e-08
172 PHOSPHORYLATION 23 1228 3.254e-09 8.803e-08
173 POSITIVE REGULATION OF KINASE ACTIVITY 15 482 3.781e-09 1.011e-07
174 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 9 121 3.762e-09 1.011e-07
175 MORPHOGENESIS OF A BRANCHING STRUCTURE 10 167 4.047e-09 1.076e-07
176 CELL ACTIVATION 16 568 4.466e-09 1.181e-07
177 APPENDAGE DEVELOPMENT 10 169 4.541e-09 1.187e-07
178 LIMB DEVELOPMENT 10 169 4.541e-09 1.187e-07
179 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 16 573 5.058e-09 1.315e-07
180 OUTFLOW TRACT MORPHOGENESIS 7 56 5.715e-09 1.477e-07
181 EMBRYONIC AXIS SPECIFICATION 6 33 7.043e-09 1.811e-07
182 EMBRYONIC PATTERN SPECIFICATION 7 58 7.355e-09 1.88e-07
183 RESPONSE TO DRUG 14 431 7.687e-09 1.954e-07
184 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 13 360 7.91e-09 1.991e-07
185 MUSCLE STRUCTURE DEVELOPMENT 14 432 7.916e-09 1.991e-07
186 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 6 34 8.522e-09 2.132e-07
187 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 15 514 8.965e-09 2.231e-07
188 CELLULAR COMPONENT DISASSEMBLY 15 515 9.201e-09 2.277e-07
189 MACROMOLECULAR COMPLEX DISASSEMBLY 10 182 9.267e-09 2.281e-07
190 RHYTHMIC PROCESS 12 298 9.334e-09 2.286e-07
191 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 16 602 1.015e-08 2.474e-07
192 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 13 370 1.096e-08 2.656e-07
193 CELL CYCLE 23 1316 1.203e-08 2.899e-07
194 REGULATION OF MUSCLE ADAPTATION 7 63 1.329e-08 3.188e-07
195 CELL DEATH 20 1001 1.461e-08 3.486e-07
196 REGULATION OF MITOTIC CELL CYCLE 14 468 2.168e-08 5.146e-07
197 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 8 104 2.218e-08 5.238e-07
198 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 11 258 2.253e-08 5.294e-07
199 EYE DEVELOPMENT 12 326 2.526e-08 5.905e-07
200 NEGATIVE REGULATION OF CELL PROLIFERATION 16 643 2.551e-08 5.934e-07
201 CELLULAR RESPONSE TO ABIOTIC STIMULUS 11 263 2.743e-08 6.351e-07
202 FC RECEPTOR SIGNALING PATHWAY 10 206 3.018e-08 6.952e-07
203 POSITIVE REGULATION OF MAP KINASE ACTIVITY 10 207 3.16e-08 7.243e-07
204 DEVELOPMENTAL GROWTH 12 333 3.191e-08 7.278e-07
205 SKIN DEVELOPMENT 10 211 3.787e-08 8.595e-07
206 REGULATION OF IMMUNE SYSTEM PROCESS 23 1403 3.946e-08 8.912e-07
207 PROTEIN COMPLEX SUBUNIT ORGANIZATION 24 1527 4.128e-08 9.279e-07
208 MITOTIC CELL CYCLE 17 766 4.686e-08 1.048e-06
209 CELL CELL SIGNALING 17 767 4.775e-08 1.063e-06
210 REGULATION OF BMP SIGNALING PATHWAY 7 77 5.49e-08 1.216e-06
211 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 11 282 5.594e-08 1.234e-06
212 PEPTIDYL THREONINE MODIFICATION 6 46 5.684e-08 1.248e-06
213 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 16 684 5.992e-08 1.309e-06
214 NEGATIVE REGULATION OF PROTEIN BINDING 7 79 6.57e-08 1.428e-06
215 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 10 228 7.851e-08 1.699e-06
216 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 10 229 8.18e-08 1.756e-06
217 REGULATION OF APOPTOTIC SIGNALING PATHWAY 12 363 8.192e-08 1.756e-06
218 POSITIVE REGULATION OF HYDROLASE ACTIVITY 18 905 9.332e-08 1.992e-06
219 UROGENITAL SYSTEM DEVELOPMENT 11 299 1.012e-07 2.151e-06
220 RESPONSE TO CYTOKINE 16 714 1.078e-07 2.28e-06
221 PALATE DEVELOPMENT 7 85 1.095e-07 2.304e-06
222 RESPONSE TO ABIOTIC STIMULUS 19 1024 1.146e-07 2.403e-06
223 NEGATIVE REGULATION OF BINDING 8 131 1.35e-07 2.803e-06
224 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 8 131 1.35e-07 2.803e-06
225 SINGLE ORGANISM CELL ADHESION 13 459 1.364e-07 2.821e-06
226 REGULATION OF GROWTH 15 633 1.383e-07 2.847e-06
227 REGULATION OF STEM CELL PROLIFERATION 7 88 1.393e-07 2.854e-06
228 POSITIVE REGULATION OF TRANSPORT 18 936 1.542e-07 3.147e-06
229 CALCIUM MEDIATED SIGNALING 7 90 1.627e-07 3.306e-06
230 EYE MORPHOGENESIS 8 136 1.803e-07 3.647e-06
231 REGULATION OF CELL GROWTH 12 391 1.829e-07 3.683e-06
232 REGULATION OF PROTEIN CATABOLIC PROCESS 12 393 1.932e-07 3.874e-06
233 GLAND DEVELOPMENT 12 395 2.04e-07 4.074e-06
234 REPRODUCTION 21 1297 2.169e-07 4.313e-06
235 LEUKOCYTE CELL CELL ADHESION 10 255 2.226e-07 4.407e-06
236 REGULATION OF IMMUNE RESPONSE 17 858 2.369e-07 4.671e-06
237 REGULATION OF CELL FATE SPECIFICATION 4 13 2.658e-07 5.218e-06
238 CARDIAC CHAMBER DEVELOPMENT 8 144 2.799e-07 5.449e-06
239 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 8 144 2.799e-07 5.449e-06
240 STEM CELL PROLIFERATION 6 60 2.889e-07 5.562e-06
241 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 19 1087 2.884e-07 5.562e-06
242 POSITIVE REGULATION OF CELL CYCLE 11 332 2.893e-07 5.562e-06
243 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 10 263 2.96e-07 5.668e-06
244 REGULATION OF ORGAN FORMATION 5 32 3.017e-07 5.754e-06
245 GROWTH 12 410 3.04e-07 5.754e-06
246 REGULATION OF CELLULAR COMPONENT MOVEMENT 16 771 3.042e-07 5.754e-06
247 EMBRYONIC DIGIT MORPHOGENESIS 6 61 3.192e-07 6.014e-06
248 RESPONSE TO ENDOGENOUS STIMULUS 22 1450 3.208e-07 6.019e-06
249 SEX DIFFERENTIATION 10 266 3.286e-07 6.14e-06
250 CAMERA TYPE EYE MORPHOGENESIS 7 101 3.599e-07 6.698e-06
251 LYMPHOCYTE ACTIVATION 11 342 3.885e-07 7.201e-06
252 REGULATION OF MESENCHYMAL CELL PROLIFERATION 5 34 4.14e-07 7.644e-06
253 LOCOMOTION 19 1114 4.196e-07 7.718e-06
254 CARDIAC CHAMBER MORPHOGENESIS 7 104 4.396e-07 8.022e-06
255 POSITIVE REGULATION OF PROTEIN IMPORT 7 104 4.396e-07 8.022e-06
256 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 8 154 4.678e-07 8.503e-06
257 FAT CELL DIFFERENTIATION 7 106 5.007e-07 9.065e-06
258 REGULATION OF MESODERM DEVELOPMENT 4 15 5.039e-07 9.087e-06
259 LENS DEVELOPMENT IN CAMERA TYPE EYE 6 66 5.13e-07 9.217e-06
260 FOREBRAIN DEVELOPMENT 11 357 5.938e-07 1.063e-05
261 REGULATION OF PROTEOLYSIS 15 711 6.08e-07 1.084e-05
262 REGULATION OF EPITHELIAL CELL PROLIFERATION 10 285 6.182e-07 1.098e-05
263 SECOND MESSENGER MEDIATED SIGNALING 8 160 6.258e-07 1.105e-05
264 POSITIVE REGULATION OF CELL PROLIFERATION 16 814 6.267e-07 1.105e-05
265 FORMATION OF PRIMARY GERM LAYER 7 110 6.444e-07 1.131e-05
266 PARAXIAL MESODERM DEVELOPMENT 4 16 6.695e-07 1.171e-05
267 RESPONSE TO ALCOHOL 11 362 6.809e-07 1.187e-05
268 BLOOD VESSEL MORPHOGENESIS 11 364 7.188e-07 1.248e-05
269 MESENCHYME MORPHOGENESIS 5 38 7.363e-07 1.274e-05
270 NEGATIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 6 71 7.943e-07 1.364e-05
271 SKIN EPIDERMIS DEVELOPMENT 6 71 7.943e-07 1.364e-05
272 REGULATION OF CATABOLIC PROCESS 15 731 8.612e-07 1.473e-05
273 REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 4 17 8.725e-07 1.476e-05
274 REGULATION OF CHROMATIN BINDING 4 17 8.725e-07 1.476e-05
275 ESTABLISHMENT OF TISSUE POLARITY 4 17 8.725e-07 1.476e-05
276 NEGATIVE REGULATION OF TRANSPORT 12 458 9.803e-07 1.653e-05
277 NEGATIVE REGULATION OF CELL GROWTH 8 170 9.904e-07 1.664e-05
278 MESODERM DEVELOPMENT 7 118 1.037e-06 1.729e-05
279 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 8 171 1.035e-06 1.729e-05
280 REGULATION OF VASCULATURE DEVELOPMENT 9 233 1.055e-06 1.752e-05
281 NEGATIVE REGULATION OF CELL DEVELOPMENT 10 303 1.078e-06 1.785e-05
282 POST ANAL TAIL MORPHOGENESIS 4 18 1.118e-06 1.845e-05
283 NEGATIVE REGULATION OF GROWTH 9 236 1.173e-06 1.928e-05
284 REGULATION OF CELLULAR RESPONSE TO HEAT 6 76 1.191e-06 1.951e-05
285 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 5 42 1.23e-06 2.009e-05
286 IN UTERO EMBRYONIC DEVELOPMENT 10 311 1.364e-06 2.219e-05
287 T CELL DIFFERENTIATION 7 123 1.372e-06 2.224e-05
288 MORPHOGENESIS OF AN EPITHELIAL SHEET 5 43 1.387e-06 2.241e-05
289 REGULATION OF NON CANONICAL WNT SIGNALING PATHWAY 4 19 1.411e-06 2.272e-05
290 KIDNEY EPITHELIUM DEVELOPMENT 7 125 1.529e-06 2.453e-05
291 LABYRINTHINE LAYER DEVELOPMENT 5 44 1.56e-06 2.494e-05
292 RESPONSE TO UV 7 126 1.613e-06 2.571e-05
293 POSITIVE REGULATION OF CELL CYCLE PROCESS 9 247 1.709e-06 2.714e-05
294 TRACHEA DEVELOPMENT 4 20 1.758e-06 2.773e-05
295 POSITIVE REGULATION OF GLYCOPROTEIN METABOLIC PROCESS 4 20 1.758e-06 2.773e-05
296 REGULATION OF CELL CYCLE PHASE TRANSITION 10 321 1.813e-06 2.85e-05
297 KIDNEY MORPHOGENESIS 6 82 1.867e-06 2.924e-05
298 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 7 129 1.889e-06 2.949e-05
299 IMMUNE SYSTEM DEVELOPMENT 13 582 1.982e-06 3.079e-05
300 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 11 404 1.985e-06 3.079e-05
301 HAIR CYCLE 6 83 2.005e-06 3.089e-05
302 MOLTING CYCLE 6 83 2.005e-06 3.089e-05
303 COCHLEA MORPHOGENESIS 4 21 2.164e-06 3.323e-05
304 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 17 1008 2.198e-06 3.365e-05
305 CARDIAC SEPTUM DEVELOPMENT 6 85 2.306e-06 3.518e-05
306 PROTEIN COMPLEX BIOGENESIS 18 1132 2.426e-06 3.665e-05
307 ANTERIOR POSTERIOR AXIS SPECIFICATION 5 48 2.424e-06 3.665e-05
308 PROTEIN COMPLEX ASSEMBLY 18 1132 2.426e-06 3.665e-05
309 LEUKOCYTE ACTIVATION 11 414 2.513e-06 3.778e-05
310 RESPONSE TO METAL ION 10 333 2.517e-06 3.778e-05
311 CONNECTIVE TISSUE DEVELOPMENT 8 194 2.665e-06 3.987e-05
312 CARDIAC SEPTUM MORPHOGENESIS 5 49 2.69e-06 4.012e-05
313 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 9 262 2.774e-06 4.124e-05
314 CELLULAR RESPONSE TO RADIATION 7 137 2.823e-06 4.184e-05
315 BIOLOGICAL ADHESION 17 1032 3.019e-06 4.46e-05
316 CELL CELL ADHESION 13 608 3.202e-06 4.714e-05
317 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 8 199 3.22e-06 4.718e-05
318 MESONEPHROS DEVELOPMENT 6 90 3.225e-06 4.718e-05
319 POSITIVE REGULATION OF FAT CELL DIFFERENTIATION 5 51 3.291e-06 4.8e-05
320 ESTABLISHMENT OR MAINTENANCE OF CELL POLARITY 7 141 3.419e-06 4.972e-05
321 PROTEASOMAL PROTEIN CATABOLIC PROCESS 9 271 3.655e-06 5.298e-05
322 INNER EAR MORPHOGENESIS 6 92 3.667e-06 5.299e-05
323 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 13 616 3.692e-06 5.318e-05
324 NEGATIVE REGULATION OF CELL CYCLE 11 433 3.864e-06 5.549e-05
325 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 5 53 3.992e-06 5.715e-05
326 CELL MOTILITY 15 835 4.432e-06 6.267e-05
327 NEGATIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 6 95 4.421e-06 6.267e-05
328 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 6 95 4.421e-06 6.267e-05
329 LOCALIZATION OF CELL 15 835 4.432e-06 6.267e-05
330 CARTILAGE DEVELOPMENT 7 147 4.507e-06 6.335e-05
331 REGULATION OF CHROMOSOME ORGANIZATION 9 278 4.497e-06 6.335e-05
332 NEGATIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 8 209 4.627e-06 6.453e-05
333 REGULATION OF CELL ADHESION 13 629 4.632e-06 6.453e-05
334 LYMPHOCYTE DIFFERENTIATION 8 209 4.627e-06 6.453e-05
335 PEPTIDYL SERINE MODIFICATION 7 148 4.713e-06 6.527e-05
336 MALE SEX DIFFERENTIATION 7 148 4.713e-06 6.527e-05
337 IMMUNE SYSTEM PROCESS 24 1984 4.83e-06 6.669e-05
338 REGULATION OF CELL FATE COMMITMENT 4 26 5.314e-06 7.315e-05
339 POSITIVE REGULATION OF PROTEOLYSIS 10 363 5.405e-06 7.419e-05
340 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 12 541 5.465e-06 7.458e-05
341 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 12 541 5.465e-06 7.458e-05
342 REGULATION OF MUSCLE CELL DIFFERENTIATION 7 152 5.62e-06 7.647e-05
343 REGULATION OF DEVELOPMENTAL GROWTH 9 289 6.156e-06 8.351e-05
344 DEVELOPMENTAL INDUCTION 4 27 6.216e-06 8.36e-05
345 RESPONSE TO LITHIUM ION 4 27 6.216e-06 8.36e-05
346 POSITIVE REGULATION OF MESENCHYMAL CELL PROLIFERATION 4 27 6.216e-06 8.36e-05
347 LEUKOCYTE DIFFERENTIATION 9 292 6.69e-06 8.946e-05
348 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 6 102 6.68e-06 8.946e-05
349 REGULATION OF NEURON DIFFERENTIATION 12 554 6.951e-06 9.267e-05
350 REGULATION OF MUSCLE TISSUE DEVELOPMENT 6 103 7.067e-06 9.342e-05
351 REGULATION OF MUSCLE ORGAN DEVELOPMENT 6 103 7.067e-06 9.342e-05
352 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 6 103 7.067e-06 9.342e-05
353 VENTRICULAR SEPTUM MORPHOGENESIS 4 28 7.227e-06 9.473e-05
354 GASTRULATION WITH MOUTH FORMING SECOND 4 28 7.227e-06 9.473e-05
355 MORPHOGENESIS OF A POLARIZED EPITHELIUM 4 28 7.227e-06 9.473e-05
356 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 11 465 7.597e-06 9.93e-05
357 REGULATION OF CELLULAR COMPONENT BIOGENESIS 14 767 8.007e-06 0.0001044
358 POSITIVE REGULATION OF STEM CELL PROLIFERATION 5 61 8.044e-06 0.0001046
359 REGULATION OF FAT CELL DIFFERENTIATION 6 106 8.341e-06 0.0001081
360 REGULATION OF CARTILAGE DEVELOPMENT 5 63 9.437e-06 0.0001216
361 REGULATION OF EPIDERMIS DEVELOPMENT 5 63 9.437e-06 0.0001216
362 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 7 166 1.002e-05 0.0001288
363 POSITIVE REGULATION OF CATABOLIC PROCESS 10 395 1.131e-05 0.0001449
364 REGULATION OF ACTIN FILAMENT BASED PROCESS 9 312 1.138e-05 0.0001455
365 EAR MORPHOGENESIS 6 112 1.145e-05 0.0001455
366 REGULATION OF OSTEOBLAST DIFFERENTIATION 6 112 1.145e-05 0.0001455
367 MUSCLE CELL DIFFERENTIATION 8 237 1.161e-05 0.0001472
368 CELLULAR RESPONSE TO UV 5 66 1.187e-05 0.0001497
369 MESODERM MORPHOGENESIS 5 66 1.187e-05 0.0001497
370 POSITIVE REGULATION OF GROWTH 8 238 1.197e-05 0.0001505
371 PATTERNING OF BLOOD VESSELS 4 32 1.252e-05 0.000157
372 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 18 1275 1.259e-05 0.0001574
373 REGULATION OF CELL SUBSTRATE ADHESION 7 173 1.311e-05 0.0001635
374 CELLULAR RESPONSE TO ALCOHOL 6 115 1.332e-05 0.0001653
375 NEPHRON DEVELOPMENT 6 115 1.332e-05 0.0001653
376 EPITHELIAL CELL DIFFERENTIATION 11 495 1.364e-05 0.0001688
377 POSITIVE REGULATION OF NON CANONICAL WNT SIGNALING PATHWAY 3 11 1.417e-05 0.0001743
378 POSITIVE REGULATION OF EMBRYONIC DEVELOPMENT 4 33 1.42e-05 0.0001743
379 POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 3 11 1.417e-05 0.0001743
380 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 10 406 1.434e-05 0.0001756
381 NEGATIVE REGULATION OF CYTOPLASMIC TRANSPORT 6 117 1.47e-05 0.0001795
382 REGULATION OF CYTOSKELETON ORGANIZATION 11 502 1.554e-05 0.0001893
383 REGULATION OF OSSIFICATION 7 178 1.577e-05 0.0001916
384 PROTEIN DESTABILIZATION 4 34 1.604e-05 0.0001943
385 CELLULAR RESPONSE TO STRESS 20 1565 1.646e-05 0.000199
386 RESPONSE TO RADIATION 10 413 1.661e-05 0.0002002
387 ENDODERM DEVELOPMENT 5 71 1.699e-05 0.0002038
388 CELL FATE SPECIFICATION 5 71 1.699e-05 0.0002038
389 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 6 121 1.781e-05 0.000213
390 REGULATION OF GASTRULATION 4 35 1.804e-05 0.0002153
391 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 6 122 1.866e-05 0.0002221
392 TRACHEA MORPHOGENESIS 3 12 1.883e-05 0.0002229
393 REGULATION OF WNT SIGNALING PATHWAY PLANAR CELL POLARITY PATHWAY 3 12 1.883e-05 0.0002229
394 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 14 829 1.915e-05 0.0002262
395 PANCREAS DEVELOPMENT 5 73 1.947e-05 0.0002287
396 EMBRYONIC HEART TUBE DEVELOPMENT 5 73 1.947e-05 0.0002287
397 REGULATION OF PEPTIDE TRANSPORT 8 256 2.025e-05 0.0002368
398 POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 36 2.023e-05 0.0002368
399 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 13 724 2.074e-05 0.0002418
400 NEURAL CREST CELL DIFFERENTIATION 5 75 2.221e-05 0.0002584
401 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 126 2.241e-05 0.0002601
402 REGULATION OF MUSCLE HYPERTROPHY 4 37 2.26e-05 0.0002616
403 PROTEIN DEPHOSPHORYLATION 7 190 2.402e-05 0.0002773
404 HEMATOPOIETIC STEM CELL PROLIFERATION 3 13 2.439e-05 0.0002796
405 REGULATION OF SKELETAL MUSCLE ADAPTATION 3 13 2.439e-05 0.0002796
406 REGULATION OF BICELLULAR TIGHT JUNCTION ASSEMBLY 3 13 2.439e-05 0.0002796
407 NEGATIVE REGULATION OF LOCOMOTION 8 263 2.457e-05 0.0002809
408 CELLULAR RESPONSE TO EXTERNAL STIMULUS 8 264 2.525e-05 0.0002872
409 REGULATION OF ACTIN FILAMENT BUNDLE ASSEMBLY 5 77 2.525e-05 0.0002872
410 RENAL TUBULE DEVELOPMENT 5 78 2.688e-05 0.0003051
411 NEGATIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 4 39 2.796e-05 0.0003157
412 COCHLEA DEVELOPMENT 4 39 2.796e-05 0.0003157
413 REGULATION OF MUSCLE SYSTEM PROCESS 7 195 2.837e-05 0.0003197
414 MAINTENANCE OF CELL NUMBER 6 132 2.916e-05 0.0003277
415 CELL MIGRATION INVOLVED IN GASTRULATION 3 14 3.095e-05 0.000347
416 REGULATION OF CELL DIVISION 8 272 3.123e-05 0.0003493
417 REGULATION OF FIBROBLAST PROLIFERATION 5 81 3.228e-05 0.0003602
418 NEGATIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 6 135 3.31e-05 0.0003684
419 SKELETAL SYSTEM MORPHOGENESIS 7 201 3.444e-05 0.0003824
420 EMBRYONIC PLACENTA DEVELOPMENT 5 83 3.632e-05 0.0004024
421 PLACENTA DEVELOPMENT 6 138 3.745e-05 0.0004139
422 GENITALIA DEVELOPMENT 4 42 3.765e-05 0.0004152
423 RESPONSE TO LIGHT STIMULUS 8 280 3.837e-05 0.000422
424 NEGATIVE REGULATION OF DENDRITE MORPHOGENESIS 3 15 3.856e-05 0.0004231
425 MITOTIC CELL CYCLE CHECKPOINT 6 139 3.9e-05 0.000427
426 NEGATIVE REGULATION OF STEM CELL DIFFERENTIATION 4 43 4.137e-05 0.0004488
427 REGULATION OF GLYCOPROTEIN METABOLIC PROCESS 4 43 4.137e-05 0.0004488
428 REGULATION OF MUSCLE CELL APOPTOTIC PROCESS 4 43 4.137e-05 0.0004488
429 REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 43 4.137e-05 0.0004488
430 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 7 207 4.153e-05 0.0004494
431 MACROMOLECULAR COMPLEX ASSEMBLY 18 1398 4.296e-05 0.0004638
432 POSITIVE REGULATION OF CYTOKINE PRODUCTION 9 370 4.349e-05 0.0004684
433 REGULATION OF CYTOKINE PRODUCTION 11 563 4.442e-05 0.0004773
434 NEGATIVE REGULATION OF INTRACELLULAR TRANSPORT 6 143 4.572e-05 0.0004902
435 MORPHOGENESIS OF AN ENDOTHELIUM 3 16 4.73e-05 0.0005036
436 ORGAN INDUCTION 3 16 4.73e-05 0.0005036
437 CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT 3 16 4.73e-05 0.0005036
438 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 6 144 4.754e-05 0.0005038
439 REGULATION OF GTPASE ACTIVITY 12 673 4.748e-05 0.0005038
440 THYMOCYTE AGGREGATION 4 45 4.961e-05 0.0005234
441 T CELL DIFFERENTIATION IN THYMUS 4 45 4.961e-05 0.0005234
442 WOUND HEALING 10 470 4.978e-05 0.000524
443 ANGIOGENESIS 8 293 5.285e-05 0.0005551
444 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 6 147 5.334e-05 0.0005589
445 ENDOTHELIUM DEVELOPMENT 5 90 5.364e-05 0.0005609
446 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 7 216 5.438e-05 0.0005673
447 REGULATION OF PROTEASOMAL UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 6 148 5.539e-05 0.0005766
448 CELLULAR RESPONSE TO LIGHT STIMULUS 5 91 5.656e-05 0.0005874
449 CELLULAR RESPONSE TO LITHIUM ION 3 17 5.725e-05 0.0005927
450 REGULATION OF HORMONE LEVELS 10 478 5.732e-05 0.0005927
451 RESPONSE TO ORGANIC CYCLIC COMPOUND 14 917 5.769e-05 0.0005952
452 RESPONSE TO INORGANIC SUBSTANCE 10 479 5.833e-05 0.0006005
453 NEPHRON EPITHELIUM DEVELOPMENT 5 93 6.276e-05 0.0006438
454 REGULATION OF PROTEIN STABILITY 7 221 6.282e-05 0.0006438
455 PALLIUM DEVELOPMENT 6 153 6.663e-05 0.0006814
456 PERICARDIUM DEVELOPMENT 3 18 6.847e-05 0.0006987
457 AMEBOIDAL TYPE CELL MIGRATION 6 154 6.909e-05 0.0007034
458 FACE DEVELOPMENT 4 50 7.538e-05 0.0007625
459 ENDODERM FORMATION 4 50 7.538e-05 0.0007625
460 RHO PROTEIN SIGNAL TRANSDUCTION 4 50 7.538e-05 0.0007625
461 TELENCEPHALON DEVELOPMENT 7 228 7.641e-05 0.0007713
462 RESPONSE TO OXYGEN LEVELS 8 311 8.019e-05 0.0008076
463 POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 4 51 8.151e-05 0.0008192
464 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 7 232 8.52e-05 0.0008544
465 CELLULAR RESPONSE TO CYTOKINE STIMULUS 11 606 8.587e-05 0.0008592
466 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 5 100 8.87e-05 0.0008857
467 CELLULAR RESPONSE TO BIOTIC STIMULUS 6 163 9.457e-05 0.0009409
468 MAMMARY GLAND EPITHELIUM DEVELOPMENT 4 53 9.486e-05 0.0009409
469 TONGUE DEVELOPMENT 3 20 9.504e-05 0.0009409
470 MESONEPHRIC TUBULE MORPHOGENESIS 4 53 9.486e-05 0.0009409
471 REGULATION OF CIRCADIAN RHYTHM 5 103 0.0001021 0.001007
472 VENTRICULAR SEPTUM DEVELOPMENT 4 54 0.0001021 0.001007
473 POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION 6 167 0.0001081 0.001063
474 CEREBRAL CORTEX DEVELOPMENT 5 105 0.0001118 0.001093
475 RESPONSE TO CARBOHYDRATE 6 168 0.0001117 0.001093
476 ODONTOGENESIS 5 105 0.0001118 0.001093
477 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 5 106 0.0001169 0.001138
478 CARDIAC VENTRICLE DEVELOPMENT 5 106 0.0001169 0.001138
479 NEGATIVE REGULATION OF PHOSPHORYLATION 9 422 0.0001189 0.001155
480 PROTEIN LOCALIZATION 20 1805 0.0001235 0.001197
481 POSITIVE REGULATION OF MUSCLE HYPERTROPHY 3 22 0.0001276 0.001225
482 SOMATIC STEM CELL DIVISION 3 22 0.0001276 0.001225
483 POSITIVE REGULATION OF CARDIAC MUSCLE HYPERTROPHY 3 22 0.0001276 0.001225
484 REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 5 108 0.0001277 0.001225
485 EMBRYONIC PLACENTA MORPHOGENESIS 3 22 0.0001276 0.001225
486 NEGATIVE REGULATION OF KINASE ACTIVITY 7 250 0.0001356 0.001298
487 RESPONSE TO EXTERNAL STIMULUS 20 1821 0.0001393 0.001331
488 VASCULOGENESIS 4 59 0.0001444 0.001377
489 NEGATIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 3 23 0.0001462 0.001388
490 EPIDERMIS DEVELOPMENT 7 253 0.0001459 0.001388
491 MITOCHONDRIAL TRANSPORT 6 177 0.0001486 0.001408
492 CELL CYCLE PHASE TRANSITION 7 255 0.0001532 0.001449
493 CHROMATIN MODIFICATION 10 539 0.000154 0.00145
494 CHONDROCYTE DIFFERENTIATION 4 60 0.0001542 0.00145
495 REGULATION OF PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 4 60 0.0001542 0.00145
496 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 9 437 0.0001545 0.00145
497 REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 6 181 0.0001678 0.001571
498 NEURON PROJECTION DEVELOPMENT 10 545 0.0001685 0.001574
499 RESPONSE TO INTERLEUKIN 1 5 115 0.0001715 0.001596
500 RESPONSE TO CALCIUM ION 5 115 0.0001715 0.001596
501 RESPONSE TO HORMONE 13 893 0.0001746 0.001621
502 REGULATION OF SMOOTHENED SIGNALING PATHWAY 4 62 0.0001752 0.001621
503 EMBRYONIC HEART TUBE MORPHOGENESIS 4 62 0.0001752 0.001621
504 REGULATION OF HORMONE SECRETION 7 262 0.0001809 0.00167
505 SPECIFICATION OF SYMMETRY 5 117 0.0001859 0.00171
506 MAMMARY GLAND DEVELOPMENT 5 117 0.0001859 0.00171
507 CHROMATIN ORGANIZATION 11 663 0.0001888 0.001733
508 EPITHELIAL CELL DEVELOPMENT 6 186 0.0001945 0.001782
509 REGULATION OF DENDRITE DEVELOPMENT 5 120 0.0002092 0.001913
510 NEGATIVE REGULATION OF CARTILAGE DEVELOPMENT 3 26 0.0002126 0.001939
511 RESPONSE TO WOUNDING 10 563 0.0002189 0.001989
512 POSITIVE REGULATION OF IMMUNE RESPONSE 10 563 0.0002189 0.001989
513 SOMATIC STEM CELL POPULATION MAINTENANCE 4 66 0.0002233 0.002025
514 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 6 191 0.0002245 0.002032
515 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 5 122 0.000226 0.002042
516 CELLULAR RESPONSE TO DRUG 4 67 0.0002367 0.00213
517 REGULATION OF SISTER CHROMATID SEGREGATION 4 67 0.0002367 0.00213
518 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 7 274 0.0002379 0.002137
519 REGULATION OF ENDOTHELIAL CELL DIFFERENTIATION 3 27 0.0002384 0.002137
520 CELL CYCLE CHECKPOINT 6 194 0.0002442 0.002185
521 REGULATION OF CELL JUNCTION ASSEMBLY 4 68 0.0002506 0.002238
522 EAR DEVELOPMENT 6 195 0.000251 0.002238
523 NEURON DEVELOPMENT 11 687 0.0002564 0.002281
524 POSITIVE REGULATION OF SECRETION 8 370 0.0002634 0.002339
525 G PROTEIN COUPLED RECEPTOR SIGNALING PATHWAY 15 1193 0.0002649 0.002348
526 NEGATIVE REGULATION OF DENDRITE DEVELOPMENT 3 28 0.0002661 0.002354
527 NEURAL PRECURSOR CELL PROLIFERATION 4 70 0.0002802 0.002465
528 MUSCLE ORGAN MORPHOGENESIS 4 70 0.0002802 0.002465
529 REGULATION OF MEMBRANE PERMEABILITY 4 70 0.0002802 0.002465
530 HOMEOSTATIC PROCESS 16 1337 0.000282 0.00247
531 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION 5 128 0.0002824 0.00247
532 MUSCLE CELL DEVELOPMENT 5 128 0.0002824 0.00247
533 REGULATION OF REPRODUCTIVE PROCESS 5 129 0.0002928 0.002551
534 CELL JUNCTION ASSEMBLY 5 129 0.0002928 0.002551
535 POSITIVE REGULATION OF CELL ADHESION 8 376 0.0002934 0.002552
536 REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 3 29 0.0002958 0.002554
537 POSITIVE REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 3 29 0.0002958 0.002554
538 STEM CELL DIVISION 3 29 0.0002958 0.002554
539 REGULATION OF HEART MORPHOGENESIS 3 29 0.0002958 0.002554
540 REGULATION OF SECRETION 11 699 0.0002973 0.002562
541 DEPHOSPHORYLATION 7 286 0.0003085 0.002653
542 ENDOTHELIAL CELL DIFFERENTIATION 4 72 0.0003123 0.002681
543 NEGATIVE REGULATION OF MAP KINASE ACTIVITY 4 73 0.0003293 0.002796
544 POSITIVE REGULATION OF PROTEIN BINDING 4 73 0.0003293 0.002796
545 ESTABLISHMENT OR MAINTENANCE OF EPITHELIAL CELL APICAL BASAL POLARITY 3 30 0.0003276 0.002796
546 NEGATIVE REGULATION OF MUSCLE CELL APOPTOTIC PROCESS 3 30 0.0003276 0.002796
547 APOPTOTIC SIGNALING PATHWAY 7 289 0.0003285 0.002796
548 RESPONSE TO X RAY 3 30 0.0003276 0.002796
549 REGULATION OF DENDRITE MORPHOGENESIS 4 74 0.0003469 0.002935
550 CELL CELL JUNCTION ASSEMBLY 4 74 0.0003469 0.002935
551 REGULATION OF PEPTIDE SECRETION 6 209 0.0003638 0.003072
552 REGULATION OF PROTEIN SECRETION 8 389 0.0003682 0.003104
553 RESPONSE TO STEROID HORMONE 9 497 0.0003991 0.003358
554 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 6 213 0.0004024 0.00338
555 MODULATION OF SYNAPTIC TRANSMISSION 7 301 0.0004195 0.003517
556 REGULATION OF SYNAPTIC PLASTICITY 5 140 0.0004267 0.003571
557 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 7 303 0.0004364 0.003645
558 REGULATION OF MITOCHONDRION ORGANIZATION 6 218 0.0004551 0.003781
559 RESPONSE TO ESTROGEN 6 218 0.0004551 0.003781
560 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 6 218 0.0004551 0.003781
561 RESPONSE TO NITROGEN COMPOUND 12 859 0.0004589 0.003806
562 REGULATION OF SYSTEM PROCESS 9 507 0.0004609 0.003816
563 CELLULAR RESPONSE TO MECHANICAL STIMULUS 4 80 0.0004671 0.003861
564 REGULATION OF PROTEIN DEACETYLATION 3 34 0.0004766 0.003918
565 ORGAN FORMATION 3 34 0.0004766 0.003918
566 NEURAL TUBE PATTERNING 3 34 0.0004766 0.003918
567 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 12 867 0.0004984 0.00409
568 SYNAPSE ORGANIZATION 5 145 0.0005009 0.004096
569 NEGATIVE REGULATION OF MAPK CASCADE 5 145 0.0005009 0.004096
570 REGULATION OF NEURON PROJECTION DEVELOPMENT 8 408 0.000505 0.004122
571 JNK CASCADE 4 82 0.0005131 0.004181
572 RESPONSE TO ESTRADIOL 5 146 0.0005169 0.004197
573 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 5 146 0.0005169 0.004197
574 CHEMICAL HOMEOSTASIS 12 874 0.0005354 0.00434
575 POSITIVE REGULATION OF CELL GROWTH 5 148 0.0005499 0.00445
576 CHROMOSOME ORGANIZATION 13 1009 0.0005644 0.004517
577 POSITIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 4 84 0.0005621 0.004517
578 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 4 84 0.0005621 0.004517
579 NEGATIVE REGULATION OF MUSCLE ORGAN DEVELOPMENT 3 36 0.000565 0.004517
580 NEGATIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 3 36 0.000565 0.004517
581 POSITIVE REGULATION OF OSSIFICATION 4 84 0.0005621 0.004517
582 HEAD MORPHOGENESIS 3 36 0.000565 0.004517
583 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 4 85 0.0005879 0.004684
584 REGULATION OF CHROMOSOME SEGREGATION 4 85 0.0005879 0.004684
585 POSITIVE REGULATION OF LOCOMOTION 8 420 0.0006107 0.00485
586 NEGATIVE REGULATION OF EPITHELIAL CELL DIFFERENTIATION 3 37 0.0006129 0.00485
587 ESTABLISHMENT OR MAINTENANCE OF APICAL BASAL CELL POLARITY 3 37 0.0006129 0.00485
588 ESTABLISHMENT OR MAINTENANCE OF BIPOLAR CELL POLARITY 3 37 0.0006129 0.00485
589 REGULATION OF CHROMATIN ORGANIZATION 5 152 0.0006207 0.004903
590 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 6 232 0.0006315 0.00498
591 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 4 88 0.0006701 0.005276
592 ACTIVATION OF IMMUNE RESPONSE 8 427 0.0006803 0.005347
593 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 5 156 0.0006981 0.005468
594 CELLULAR RESPONSE TO INORGANIC SUBSTANCE 5 156 0.0006981 0.005468
595 EPITHELIAL CELL PROLIFERATION 4 89 0.0006993 0.005469
596 CELL PROJECTION ORGANIZATION 12 902 0.000707 0.005519
597 NEGATIVE REGULATION OF PROTEOLYSIS 7 329 0.0007108 0.00554
598 REGULATION OF CELL MATRIX ADHESION 4 90 0.0007293 0.005675
599 APICAL JUNCTION ASSEMBLY 3 40 0.0007718 0.005975
600 REGULATION OF MEIOTIC CELL CYCLE 3 40 0.0007718 0.005975
601 POSITIVE REGULATION OF CELL MATRIX ADHESION 3 40 0.0007718 0.005975
602 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 8 437 0.0007907 0.006111
603 MITOCHONDRIAL MEMBRANE ORGANIZATION 4 92 0.0007921 0.006112
604 REGULATION OF MICROTUBULE BASED PROCESS 6 243 0.0008041 0.006194
605 NEGATIVE REGULATION OF STRESS ACTIVATED MAPK CASCADE 3 41 0.00083 0.006363
606 NEGATIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 3 41 0.00083 0.006363
607 PROSTATE GLAND DEVELOPMENT 3 41 0.00083 0.006363
608 RESPONSE TO EXTRACELLULAR STIMULUS 8 441 0.0008386 0.006418
609 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 6 246 0.0008569 0.006547
610 SYSTEM PROCESS 18 1785 0.0008848 0.006749
611 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 4 95 0.0008933 0.006803
612 REGULATION OF CELL PROJECTION ORGANIZATION 9 558 0.0009124 0.006937
613 COVALENT CHROMATIN MODIFICATION 7 345 0.0009382 0.007121
614 OSSIFICATION 6 251 0.0009509 0.007206
615 PROTEOLYSIS 14 1208 0.0009675 0.00732
616 REGULATION OF AXONOGENESIS 5 168 0.000974 0.007357
617 MEMORY 4 98 0.001003 0.007542
618 POSITIVE REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 4 98 0.001003 0.007542
619 RESPONSE TO VITAMIN 4 98 0.001003 0.007542
620 BODY MORPHOGENESIS 3 44 0.001021 0.00764
621 BRANCHING INVOLVED IN URETERIC BUD MORPHOGENESIS 3 44 0.001021 0.00764
622 NEGATIVE REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 3 44 0.001021 0.00764
623 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 7 351 0.001037 0.007745
624 POSITIVE REGULATION OF CELL SUBSTRATE ADHESION 4 99 0.001042 0.00777
625 PRIMITIVE STREAK FORMATION 2 11 0.001073 0.007961
626 ENDOCARDIUM DEVELOPMENT 2 11 0.001073 0.007961
627 ENDOTHELIAL TUBE MORPHOGENESIS 2 11 0.001073 0.007961
628 LUNG MORPHOGENESIS 3 45 0.001091 0.008068
629 REGULATION OF EPIDERMAL CELL DIFFERENTIATION 3 45 0.001091 0.008068
630 CELL DIVISION 8 460 0.0011 0.008122
631 STRIATED MUSCLE CELL DIFFERENTIATION 5 173 0.00111 0.008186
632 REGULATION OF CHONDROCYTE DIFFERENTIATION 3 46 0.001163 0.008562
633 POSITIVE REGULATION OF CYTOSKELETON ORGANIZATION 5 175 0.001168 0.008588
634 PROTEIN CATABOLIC PROCESS 9 579 0.001181 0.008668
635 POSITIVE REGULATION BY HOST OF VIRAL TRANSCRIPTION 2 12 0.001284 0.009274
636 ANTERIOR POSTERIOR AXIS SPECIFICATION EMBRYO 2 12 0.001284 0.009274
637 CARTILAGE MORPHOGENESIS 2 12 0.001284 0.009274
638 REGULATION OF ENDOTHELIAL CELL DEVELOPMENT 2 12 0.001284 0.009274
639 ROSTROCAUDAL NEURAL TUBE PATTERNING 2 12 0.001284 0.009274
640 HEART FORMATION 2 12 0.001284 0.009274
641 REGULATION OF ESTABLISHMENT OF ENDOTHELIAL BARRIER 2 12 0.001284 0.009274
642 TRIPARTITE REGIONAL SUBDIVISION 2 12 0.001284 0.009274
643 MAMMARY GLAND EPITHELIAL CELL PROLIFERATION 2 12 0.001284 0.009274
644 LENS FIBER CELL DEVELOPMENT 2 12 0.001284 0.009274
645 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 3 48 0.001316 0.009468
646 REGULATION OF MYOBLAST DIFFERENTIATION 3 48 0.001316 0.009468
647 POSITIVE REGULATION OF ACTIN FILAMENT BUNDLE ASSEMBLY 3 48 0.001316 0.009468
648 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 7 368 0.001362 0.009778
649 PEPTIDYL AMINO ACID MODIFICATION 11 841 0.001369 0.009814
650 RESPONSE TO KETONE 5 182 0.00139 0.009951
NumGOOverlapSizeP ValueAdj. P Value
1 WNT PROTEIN BINDING 14 31 1.206e-25 5.602e-23
2 WNT ACTIVATED RECEPTOR ACTIVITY 13 22 6.04e-26 5.602e-23
3 FRIZZLED BINDING 14 36 1.696e-24 5.252e-22
4 BETA CATENIN BINDING 15 84 2.133e-20 4.954e-18
5 ENZYME BINDING 32 1737 1.358e-12 2.524e-10
6 TRANSCRIPTION FACTOR BINDING 19 524 1.645e-12 2.548e-10
7 G PROTEIN COUPLED RECEPTOR BINDING 14 259 9.882e-12 1.311e-09
8 RECEPTOR BINDING 27 1476 1.579e-10 1.834e-08
9 SIGNAL TRANSDUCER ACTIVITY 29 1731 2.158e-10 2.227e-08
10 PROTEIN DOMAIN SPECIFIC BINDING 18 624 2.877e-10 2.673e-08
11 PROTEIN SERINE THREONINE KINASE ACTIVITY 15 445 1.278e-09 1.08e-07
12 PDZ DOMAIN BINDING 8 90 7.024e-09 5.438e-07
13 REGULATORY REGION NUCLEIC ACID BINDING 18 818 2.019e-08 1.443e-06
14 PROTEIN KINASE ACTIVITY 16 640 2.39e-08 1.586e-06
15 I SMAD BINDING 4 11 1.235e-07 7.649e-06
16 GAMMA CATENIN BINDING 4 12 1.846e-07 1.072e-05
17 ARMADILLO REPEAT DOMAIN BINDING 4 13 2.658e-07 1.452e-05
18 MAP KINASE ACTIVITY 4 14 3.708e-07 1.914e-05
19 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 7 104 4.396e-07 2.15e-05
20 KINASE BINDING 14 606 5.134e-07 2.385e-05
21 SMAD BINDING 6 72 8.634e-07 3.819e-05
22 KINASE ACTIVITY 16 842 9.786e-07 4.132e-05
23 RHO GTPASE BINDING 6 78 1.389e-06 5.61e-05
24 CALMODULIN BINDING 8 179 1.46e-06 5.653e-05
25 UBIQUITIN LIKE PROTEIN LIGASE BINDING 9 264 2.952e-06 0.0001097
26 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 13 629 4.632e-06 0.0001655
27 CORE PROMOTER PROXIMAL REGION DNA BINDING 10 371 6.546e-06 0.0002252
28 MOLECULAR FUNCTION REGULATOR 19 1353 7.435e-06 0.0002467
29 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 16 992 8.036e-06 0.0002574
30 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 9 315 1.228e-05 0.0003803
31 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 17 1199 2.163e-05 0.0006482
32 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR BINDING 3 15 3.856e-05 0.001119
33 PHOSPHORIC ESTER HYDROLASE ACTIVITY 9 368 4.17e-05 0.001174
34 PROTEIN DIMERIZATION ACTIVITY 16 1149 4.864e-05 0.00128
35 RECEPTOR AGONIST ACTIVITY 3 16 4.73e-05 0.00128
36 RECEPTOR REGULATOR ACTIVITY 4 45 4.961e-05 0.00128
37 SEQUENCE SPECIFIC DNA BINDING 15 1037 5.634e-05 0.001415
38 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 8 328 0.0001159 0.002834
39 ACTIVATING TRANSCRIPTION FACTOR BINDING 4 57 0.0001262 0.00295
40 RECEPTOR SIGNALING PROTEIN ACTIVITY 6 172 0.000127 0.00295
41 DRUG BINDING 5 109 0.0001333 0.003021
42 R SMAD BINDING 3 23 0.0001462 0.003226
43 CHROMATIN BINDING 9 435 0.0001493 0.003226
44 PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 6 178 0.0001532 0.003234
45 DOUBLE STRANDED DNA BINDING 12 764 0.0001577 0.003256
46 MITOGEN ACTIVATED PROTEIN KINASE BINDING 3 24 0.0001666 0.003364
47 PROTEIN SERINE THREONINE PHOSPHATASE ACTIVITY 4 64 0.0001982 0.003918
48 P53 BINDING 4 67 0.0002367 0.004581
49 CALMODULIN DEPENDENT PROTEIN KINASE ACTIVITY 3 28 0.0002661 0.004944
50 CADHERIN BINDING 3 28 0.0002661 0.004944
51 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 10 588 0.0003094 0.005637
52 NF KAPPAB BINDING 3 30 0.0003276 0.005853
53 PHOSPHOLIPASE C ACTIVITY 3 31 0.0003616 0.006337
54 TRANSCRIPTION COACTIVATOR ACTIVITY 7 296 0.0003794 0.006527
55 RECEPTOR ACTIVATOR ACTIVITY 3 32 0.0003977 0.006717
56 STEROID HORMONE RECEPTOR BINDING 4 81 0.0004897 0.008124
57 G PROTEIN COUPLED RECEPTOR ACTIVITY 12 879 0.0005631 0.008897
58 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 6 226 0.0005504 0.008897
59 RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING 3 36 0.000565 0.008897
NumGOOverlapSizeP ValueAdj. P Value
1 BETA CATENIN DESTRUCTION COMPLEX 8 14 3.592e-16 2.098e-13
2 WNT SIGNALOSOME 7 11 9.578e-15 2.797e-12
3 PHOSPHATASE COMPLEX 7 48 1.868e-09 3.636e-07
4 TRANSCRIPTION FACTOR COMPLEX 12 298 9.334e-09 1.363e-06
5 ENDOCYTIC VESICLE MEMBRANE 8 152 4.234e-07 4.946e-05
6 NUCLEAR CHROMATIN 10 291 7.473e-07 7.274e-05
7 CHROMOSOME 16 880 1.741e-06 0.0001141
8 NUCLEAR TRANSCRIPTION FACTOR COMPLEX 7 127 1.701e-06 0.0001141
9 PROTEIN PHOSPHATASE TYPE 2A COMPLEX 4 20 1.758e-06 0.0001141
10 ENDOCYTIC VESICLE 9 256 2.294e-06 0.000134
11 EXTRACELLULAR MATRIX 11 426 3.306e-06 0.0001755
12 CHROMATIN 11 441 4.6e-06 0.0002066
13 PROTEINACEOUS EXTRACELLULAR MATRIX 10 356 4.553e-06 0.0002066
14 CELL SURFACE 14 757 6.899e-06 0.0002878
15 CATALYTIC COMPLEX 15 1038 5.696e-05 0.002218
16 CENTROSOME 10 487 6.696e-05 0.002444
17 LATERAL PLASMA MEMBRANE 4 50 7.538e-05 0.002589
18 RNA POLYMERASE II TRANSCRIPTION FACTOR COMPLEX 5 101 9.299e-05 0.003017
19 MICROTUBULE ORGANIZING CENTER 11 623 0.0001097 0.003371
20 NUCLEAR CHROMOSOME 10 523 0.0001205 0.003519
21 LAMELLIPODIUM 6 172 0.000127 0.003533
22 INTRACELLULAR VESICLE 16 1259 0.0001423 0.003613
23 SYNAPSE 12 754 0.0001395 0.003613
24 CYTOSKELETAL PART 17 1436 0.0002011 0.004894
25 CLATHRIN COATED ENDOCYTIC VESICLE 4 65 0.0002105 0.004917
26 MICROTUBULE CYTOSKELETON 14 1068 0.000285 0.006164
27 APICAL JUNCTION COMPLEX 5 128 0.0002824 0.006164
28 CELL CELL JUNCTION 8 383 0.000332 0.006924
29 CYTOSKELETON 20 1967 0.0003889 0.007831
30 VESICLE MEMBRANE 9 512 0.0004947 0.009631

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04310_Wnt_signaling_pathway 90 151 1.678e-206 3.02e-204
2 hsa04916_Melanogenesis 35 101 4.924e-59 4.432e-57
3 hsa04390_Hippo_signaling_pathway 34 154 1.409e-49 8.456e-48
4 hsa04720_Long.term_potentiation 15 70 1.092e-21 4.913e-20
5 hsa04520_Adherens_junction 13 73 8.724e-18 3.141e-16
6 hsa04340_Hedgehog_signaling_pathway 12 56 1.531e-17 4.593e-16
7 hsa04114_Oocyte_meiosis 13 114 3.782e-15 9.726e-14
8 hsa04360_Axon_guidance 13 130 2.156e-14 4.85e-13
9 hsa04912_GnRH_signaling_pathway 12 101 2.778e-14 5.555e-13
10 hsa04662_B_cell_receptor_signaling_pathway 11 75 3.157e-14 5.682e-13
11 hsa04370_VEGF_signaling_pathway 11 76 3.678e-14 6.018e-13
12 hsa04010_MAPK_signaling_pathway 15 268 1.017e-12 1.526e-11
13 hsa04020_Calcium_signaling_pathway 13 177 1.191e-12 1.649e-11
14 hsa04660_T_cell_receptor_signaling_pathway 11 108 1.972e-12 2.536e-11
15 hsa04350_TGF.beta_signaling_pathway 10 85 4.836e-12 5.804e-11
16 hsa04012_ErbB_signaling_pathway 10 87 6.139e-12 6.906e-11
17 hsa04650_Natural_killer_cell_mediated_cytotoxicity 11 136 2.514e-11 2.662e-10
18 hsa04971_Gastric_acid_secretion 9 74 4.371e-11 4.371e-10
19 hsa04510_Focal_adhesion 12 200 9.944e-11 9.421e-10
20 hsa04270_Vascular_smooth_muscle_contraction 9 116 2.586e-09 2.327e-08
21 hsa04722_Neurotrophin_signaling_pathway 9 127 5.774e-09 4.949e-08
22 hsa04110_Cell_cycle 8 128 1.128e-07 8.825e-07
23 hsa04380_Osteoclast_differentiation 8 128 1.128e-07 8.825e-07
24 hsa04062_Chemokine_signaling_pathway 9 189 1.815e-07 1.361e-06
25 hsa04730_Long.term_depression 6 70 7.298e-07 5.254e-06
26 hsa04664_Fc_epsilon_RI_signaling_pathway 6 79 1.498e-06 1.037e-05
27 hsa04330_Notch_signaling_pathway 5 47 2.179e-06 1.453e-05
28 hsa04970_Salivary_secretion 6 89 3.021e-06 1.942e-05
29 hsa04540_Gap_junction 6 90 3.225e-06 2.002e-05
30 hsa04972_Pancreatic_secretion 6 101 6.309e-06 3.786e-05
31 hsa04014_Ras_signaling_pathway 8 236 1.126e-05 6.537e-05
32 hsa04670_Leukocyte_transendothelial_migration 6 117 1.47e-05 8.269e-05
33 hsa04070_Phosphatidylinositol_signaling_system 5 78 2.688e-05 0.0001466
34 hsa04530_Tight_junction 6 133 3.043e-05 0.0001611
35 hsa04210_Apoptosis 5 89 5.084e-05 0.0002615
36 hsa04910_Insulin_signaling_pathway 5 138 0.0003994 0.001997
37 hsa04810_Regulation_of_actin_cytoskeleton 6 214 0.0004126 0.002007
38 hsa04914_Progesterone.mediated_oocyte_maturation 4 87 0.0006419 0.00304
39 hsa04151_PI3K_AKT_signaling_pathway 7 351 0.001037 0.004786
40 hsa00562_Inositol_phosphate_metabolism 3 57 0.002163 0.009734
41 hsa04621_NOD.like_receptor_signaling_pathway 3 59 0.002388 0.01048
42 hsa04920_Adipocytokine_signaling_pathway 3 68 0.003576 0.01532
43 hsa04622_RIG.I.like_receptor_signaling_pathway 3 71 0.004038 0.01691
44 hsa04710_Circadian_rhythm_._mammal 2 23 0.004764 0.01949
45 hsa04630_Jak.STAT_signaling_pathway 4 155 0.005292 0.02117
46 hsa03015_mRNA_surveillance_pathway 3 83 0.006246 0.02444
47 hsa04141_Protein_processing_in_endoplasmic_reticulum 4 168 0.007011 0.02685
48 hsa04620_Toll.like_receptor_signaling_pathway 3 102 0.01098 0.04118
49 hsa04960_Aldosterone.regulated_sodium_reabsorption 2 42 0.01534 0.05636
50 hsa04973_Carbohydrate_digestion_and_absorption 2 44 0.01676 0.06033
51 hsa04742_Taste_transduction 2 52 0.02295 0.08102
52 hsa04120_Ubiquitin_mediated_proteolysis 3 139 0.02489 0.08614
53 hsa04115_p53_signaling_pathway 2 69 0.03867 0.1313
54 hsa04666_Fc_gamma_R.mediated_phagocytosis 2 95 0.06833 0.2278
55 hsa04740_Olfactory_transduction 4 388 0.09784 0.3202
56 hsa04144_Endocytosis 2 203 0.2322 0.7333

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

EMX2OS

 hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-130b-5p;hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-18a-5p;hsa-miR-18b-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-221-5p;hsa-miR-26a-1-3p;hsa-miR-26a-2-3p;hsa-miR-27a-3p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-33a-3p;hsa-miR-33a-5p;hsa-miR-33b-5p;hsa-miR-374a-3p;hsa-miR-421;hsa-miR-484;hsa-miR-576-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-624-5p;hsa-miR-629-3p;hsa-miR-7-1-3p 38 PRICKLE2 Sponge network 1.057 0.31716 0.551 0.42536 0.586
2

CECR7

 hsa-miR-141-5p;hsa-miR-148a-5p;hsa-miR-16-2-3p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-24-3p;hsa-miR-26b-5p;hsa-miR-29a-5p;hsa-miR-29b-1-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-361-5p;hsa-miR-429;hsa-miR-491-5p;hsa-miR-502-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p 24 PRKCB Sponge network 0.551 0.56177 -0.289 0.6299 0.583
3

EMX2OS

 hsa-miR-144-3p;hsa-miR-146a-5p;hsa-miR-16-1-3p;hsa-miR-182-5p;hsa-miR-192-3p;hsa-miR-19b-1-5p;hsa-miR-26b-3p;hsa-miR-27a-3p;hsa-miR-29a-5p;hsa-miR-30d-3p;hsa-miR-335-5p;hsa-miR-33a-3p;hsa-miR-484;hsa-miR-576-5p;hsa-miR-625-5p;hsa-miR-7-1-3p;hsa-miR-940 17 SFRP1 Sponge network 1.057 0.31716 0.459 0.49771 0.573
4

EMX2OS

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-15b-3p;hsa-miR-17-5p;hsa-miR-185-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-30b-3p;hsa-miR-30d-3p;hsa-miR-362-3p;hsa-miR-505-5p;hsa-miR-590-3p;hsa-miR-93-5p 17 TCF7L1 Sponge network 1.057 0.31716 0.403 0.47966 0.509
5

CECR7

 hsa-miR-130b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p 13 MAPK10 Sponge network 0.551 0.56177 0.278 0.49976 0.504
6

EMX2OS

 hsa-let-7a-3p;hsa-let-7d-5p;hsa-let-7f-1-3p;hsa-let-7g-3p;hsa-let-7g-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-10a-5p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-27a-3p;hsa-miR-301a-3p;hsa-miR-32-3p;hsa-miR-32-5p;hsa-miR-324-3p;hsa-miR-33a-3p;hsa-miR-375;hsa-miR-424-5p;hsa-miR-452-5p;hsa-miR-454-3p;hsa-miR-484;hsa-miR-505-5p;hsa-miR-576-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-7-1-3p;hsa-miR-92a-3p;hsa-miR-940 41 FZD4 Sponge network 1.057 0.31716 0.088 0.9264 0.501
7

CECR7

 hsa-miR-1275;hsa-miR-16-1-3p;hsa-miR-182-5p;hsa-miR-192-3p;hsa-miR-19b-1-5p;hsa-miR-26b-3p;hsa-miR-29a-5p;hsa-miR-335-5p;hsa-miR-33a-3p;hsa-miR-429;hsa-miR-625-5p;hsa-miR-7-1-3p 12 SFRP1 Sponge network 0.551 0.56177 0.459 0.49771 0.494
8

CECR7

 hsa-let-7a-3p;hsa-let-7d-5p;hsa-let-7f-1-3p;hsa-let-7g-3p;hsa-let-7g-5p;hsa-miR-106b-5p;hsa-miR-10a-5p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-24-3p;hsa-miR-25-3p;hsa-miR-301a-3p;hsa-miR-32-3p;hsa-miR-324-3p;hsa-miR-33a-3p;hsa-miR-361-5p;hsa-miR-375;hsa-miR-429;hsa-miR-454-3p;hsa-miR-505-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-7-1-3p 36 FZD4 Sponge network 0.551 0.56177 0.088 0.9264 0.486
9

EMX2OS

 hsa-miR-146a-5p;hsa-miR-148b-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-200a-5p;hsa-miR-200b-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-335-5p;hsa-miR-577;hsa-miR-590-3p;hsa-miR-93-3p 12 FZD1 Sponge network 1.057 0.31716 -0.051 0.95908 0.447
10

EMX2OS

 hsa-miR-141-5p;hsa-miR-182-5p;hsa-miR-18a-5p;hsa-miR-1976;hsa-miR-19b-3p;hsa-miR-335-5p;hsa-miR-339-5p;hsa-miR-421;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-592 11 DAAM2 Sponge network 1.057 0.31716 0.123 0.86624 0.445
11

CECR7

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-15b-3p;hsa-miR-17-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-362-3p;hsa-miR-429;hsa-miR-505-5p;hsa-miR-590-3p;hsa-miR-93-5p 15 TCF7L1 Sponge network 0.551 0.56177 0.403 0.47966 0.437
12

CECR7

 hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-let-7f-2-3p;hsa-miR-130b-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-18a-5p;hsa-miR-18b-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-221-5p;hsa-miR-26a-1-3p;hsa-miR-26a-2-3p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-33a-3p;hsa-miR-33a-5p;hsa-miR-33b-5p;hsa-miR-361-5p;hsa-miR-362-5p;hsa-miR-429;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-7-1-3p 36 PRICKLE2 Sponge network 0.551 0.56177 0.551 0.42536 0.432
13

MEG3

 hsa-let-7f-5p;hsa-let-7g-5p;hsa-miR-106b-5p;hsa-miR-10a-5p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-429;hsa-miR-576-5p;hsa-miR-590-5p;hsa-miR-7-1-3p 19 FZD4 Sponge network 0.433 0.33816 0.088 0.9264 0.417
14

EMX2OS

 hsa-miR-130b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-30d-3p;hsa-miR-454-3p;hsa-miR-590-3p;hsa-miR-940 12 MAPK10 Sponge network 1.057 0.31716 0.278 0.49976 0.408
15

EMX2OS

 hsa-miR-141-5p;hsa-miR-148a-5p;hsa-miR-16-2-3p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-26b-5p;hsa-miR-27a-3p;hsa-miR-29a-5p;hsa-miR-29b-1-5p;hsa-miR-30d-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-452-3p;hsa-miR-484;hsa-miR-502-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-7-5p 21 PRKCB Sponge network 1.057 0.31716 -0.289 0.6299 0.407
16

MEG3

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-141-3p;hsa-miR-15b-3p;hsa-miR-17-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-30b-3p;hsa-miR-30d-3p;hsa-miR-429;hsa-miR-93-5p 13 TCF7L1 Sponge network 0.433 0.33816 0.403 0.47966 0.398
17 MIAT hsa-miR-106b-5p;hsa-miR-10a-5p;hsa-miR-141-3p;hsa-miR-192-5p;hsa-miR-200c-3p;hsa-miR-24-3p;hsa-miR-301a-3p;hsa-miR-454-3p;hsa-miR-92a-3p;hsa-miR-98-5p 10 FZD4 Sponge network -0.118 0.86338 0.088 0.9264 0.397
18

MEG3

 hsa-miR-146a-5p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-221-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-429;hsa-miR-576-5p;hsa-miR-590-5p;hsa-miR-7-1-3p 17 PRICKLE2 Sponge network 0.433 0.33816 0.551 0.42536 0.389
19

CECR7

 hsa-miR-1275;hsa-miR-148b-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-200a-5p;hsa-miR-200b-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-335-5p;hsa-miR-590-3p 10 FZD1 Sponge network 0.551 0.56177 -0.051 0.95908 0.388

Quest ID: 3b5b458c0f360b4ca0990124d9d42bb3