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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-199a-5p ADAM17 1.31 0 -0.49 0.00093 miRanda -0.13 1.0E-5 NA
2 hsa-miR-199b-5p ADAM17 2.14 0 -0.49 0.00093 miRanda -0.13 0 NA
3 hsa-miR-26b-5p CREBBP 0.72 5.0E-5 -0.12 0.3327 miRNATAP -0.11 0.00062 NA
4 hsa-miR-590-3p CREBBP 0.84 0.00129 -0.12 0.3327 PITA; miRanda; mirMAP; miRNATAP -0.14 0 NA
5 hsa-miR-342-3p CTBP2 -0.13 0.56103 0.4 0.00034 MirTarget; PITA; miRanda; miRNATAP -0.16 0 NA
6 hsa-miR-146b-5p DLL1 1.09 1.0E-5 -1.1 0.0002 miRanda -0.2 0.00029 NA
7 hsa-miR-34a-5p DLL1 1.41 0 -1.1 0.0002 miRNAWalker2 validate; miRTarBase; miRNATAP -0.24 0.0003 22438124 Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells
8 hsa-miR-589-5p DLL1 0.23 0.22848 -1.1 0.0002 miRNATAP -0.19 0.00779 NA
9 hsa-miR-15a-5p DLL4 1.63 0 -0.95 0 miRNATAP -0.17 0.00062 NA
10 hsa-miR-16-5p DLL4 0.75 0 -0.95 0 miRNATAP -0.24 3.0E-5 NA
11 hsa-miR-28-3p DLL4 0.39 0.00778 -0.95 0 miRNATAP -0.24 0.00026 NA
12 hsa-let-7a-5p DTX2 -1.37 0 1.15 0 TargetScan; miRNATAP -0.21 2.0E-5 NA
13 hsa-let-7b-5p DTX2 -1.62 0 1.15 0 miRNATAP -0.13 0.00391 NA
14 hsa-let-7d-5p DTX2 -0.62 6.0E-5 1.15 0 miRNATAP -0.18 0.00275 NA
15 hsa-let-7e-5p DTX2 -0.75 7.0E-5 1.15 0 miRNATAP -0.18 0.00026 NA
16 hsa-let-7f-5p DTX2 -0.05 0.83408 1.15 0 miRNATAP -0.12 0.00115 NA
17 hsa-miR-186-5p DTX3L 0.85 0 0.22 0.10684 MirTarget -0.12 0.00945 NA
18 hsa-miR-365a-3p DTX4 0.01 0.9536 -0.7 0.00259 mirMAP -0.14 0.00282 NA
19 hsa-miR-421 DTX4 0.17 0.53528 -0.7 0.00259 mirMAP -0.25 0 NA
20 hsa-miR-10a-5p DVL1 0.79 0.00059 0.54 0.00279 miRNAWalker2 validate -0.19 0 NA
21 hsa-miR-378a-3p DVL1 -2.01 0 0.54 0.00279 miRNAWalker2 validate -0.15 2.0E-5 NA
22 hsa-miR-221-3p DVL2 -0.1 0.65445 0.15 0.17346 miRNAWalker2 validate -0.15 0 21487968 MiR 221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2; We also suggest that miR-221 may control the migration of AIPC cells through DVL2 working as a key regulator in advanced CaP
23 hsa-miR-27a-3p DVL2 0.43 0.00737 0.15 0.17346 miRNATAP -0.13 4.0E-5 NA
24 hsa-miR-27b-3p DVL2 0.24 0.12264 0.15 0.17346 miRNATAP -0.11 0.00124 NA
25 hsa-let-7a-5p DVL3 -1.37 0 0.47 5.0E-5 TargetScan -0.2 0 NA
26 hsa-miR-26b-5p DVL3 0.72 5.0E-5 0.47 5.0E-5 miRNAWalker2 validate -0.11 0.00043 NA
27 hsa-miR-30a-3p DVL3 -2.54 0 0.47 5.0E-5 MirTarget -0.11 0 NA
28 hsa-miR-30d-3p DVL3 0 0.98646 0.47 5.0E-5 MirTarget -0.1 7.0E-5 NA
29 hsa-miR-30e-3p DVL3 -0.1 0.52624 0.47 5.0E-5 MirTarget -0.13 4.0E-5 NA
30 hsa-miR-140-5p EP300 0.67 0.00034 -0.24 0.04641 miRNAWalker2 validate -0.13 1.0E-5 NA
31 hsa-miR-142-5p EP300 1.3 0 -0.24 0.04641 PITA; mirMAP; miRNATAP -0.12 0 23342264 In contrast to the mouse p300 gene the human p300 gene was not found to be a target for miR-142-5p
32 hsa-miR-26b-5p EP300 0.72 5.0E-5 -0.24 0.04641 miRNAWalker2 validate; miRNATAP -0.19 0 NA
33 hsa-miR-342-3p EP300 -0.13 0.56103 -0.24 0.04641 MirTarget; PITA; miRanda; miRNATAP -0.16 0 NA
34 hsa-miR-590-3p EP300 0.84 0.00129 -0.24 0.04641 MirTarget; PITA; miRanda; mirMAP; miRNATAP -0.13 0 NA
35 hsa-miR-96-5p EP300 3.04 0 -0.24 0.04641 TargetScan; miRNATAP -0.11 0 NA
36 hsa-let-7b-3p HDAC2 -1.82 0 0.48 0.00021 mirMAP -0.13 0 NA
37 hsa-miR-145-5p HDAC2 -1.35 0 0.48 0.00021 miRNAWalker2 validate -0.12 0 23499894 MiR 145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer; Ectopic expression of miRNA mimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells; In conclusion we suggest that loss or suppression of miR-145 may cause aberrant overexpression of HDAC2 and promote HCC tumorigenesis
38 hsa-miR-146a-5p HDAC2 0.68 0.01053 0.48 0.00021 mirMAP -0.12 0 NA
39 hsa-miR-195-3p HDAC2 -1.33 0 0.48 0.00021 mirMAP -0.2 0 NA
40 hsa-miR-30a-5p HDAC2 -0.92 0.00076 0.48 0.00021 mirMAP -0.14 0 NA
41 hsa-miR-30b-5p HDAC2 0.36 0.13803 0.48 0.00021 mirMAP -0.16 0 NA
42 hsa-miR-30c-5p HDAC2 -0.33 0.1236 0.48 0.00021 mirMAP -0.22 0 NA
43 hsa-miR-30d-3p HDAC2 0 0.98646 0.48 0.00021 mirMAP -0.14 0 NA
44 hsa-miR-30d-5p HDAC2 -0.92 4.0E-5 0.48 0.00021 mirMAP -0.21 0 NA
45 hsa-miR-320a HDAC2 -0.96 0 0.48 0.00021 miRanda; mirMAP -0.11 0.00142 NA
46 hsa-miR-141-3p JAG1 3.37 0 -0.94 0.0001 TargetScan; miRNATAP -0.2 0 NA
47 hsa-miR-146b-5p JAG1 1.09 1.0E-5 -0.94 0.0001 miRanda -0.18 0.00014 NA
48 hsa-miR-16-1-3p JAG1 1.5 0 -0.94 0.0001 MirTarget -0.16 0.0035 NA
49 hsa-miR-186-5p JAG1 0.85 0 -0.94 0.0001 MirTarget; miRNATAP -0.27 0.00066 NA
50 hsa-miR-200c-3p JAG1 0.38 0.08422 -0.94 0.0001 miRNAWalker2 validate -0.2 7.0E-5 NA
51 hsa-miR-21-5p JAG1 4.38 0 -0.94 0.0001 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.19 0 NA
52 hsa-miR-3065-5p JAG1 0.65 0.09995 -0.94 0.0001 MirTarget; mirMAP; miRNATAP -0.1 0.00068 NA
53 hsa-miR-335-3p JAG1 1.51 0 -0.94 0.0001 MirTarget -0.2 0.0001 NA
54 hsa-miR-34a-5p JAG1 1.41 0 -0.94 0.0001 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.23 1.0E-5 NA
55 hsa-miR-375 JAG1 0.62 0.1492 -0.94 0.0001 miRNAWalker2 validate -0.16 0 NA
56 hsa-miR-450b-5p JAG1 1.69 0 -0.94 0.0001 miRNATAP -0.11 0.00541 NA
57 hsa-miR-590-5p JAG1 2.07 0 -0.94 0.0001 MirTarget; PITA; miRanda; miRNATAP -0.13 0.00829 NA
58 hsa-miR-628-5p JAG1 1.06 0 -0.94 0.0001 MirTarget; PITA; miRNATAP -0.19 0.00095 NA
59 hsa-miR-30a-5p JAG2 -0.92 0.00076 0.03 0.91715 miRNATAP -0.19 0 NA
60 hsa-miR-502-3p JAG2 -0.26 0.16176 0.03 0.91715 miRNATAP -0.16 0.00892 NA
61 hsa-miR-106a-5p KAT2B 1.39 6.0E-5 -1.27 0 MirTarget -0.19 0 NA
62 hsa-miR-106b-5p KAT2B 1.47 0 -1.27 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.36 0 NA
63 hsa-miR-17-5p KAT2B 2.07 0 -1.27 0 MirTarget; TargetScan -0.32 0 23095762 miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of PCAF by miR-17-5p was evaluated using the luciferase reporter assay; Expression of PCAF in PCa cells was associated with the downregulation of miR-17-5p; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; PCAF is upregulated in cultured PCa cells and upregulation of PCAF is associated with the downregulation of miR-17-5p; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells
64 hsa-miR-181d-5p KAT2B 1.19 0 -1.27 0 MirTarget -0.13 0.00114 NA
65 hsa-miR-19a-3p KAT2B 2.12 0 -1.27 0 miRNAWalker2 validate -0.23 0 NA
66 hsa-miR-19b-3p KAT2B 2.11 0 -1.27 0 miRNAWalker2 validate -0.24 0 NA
67 hsa-miR-20a-3p KAT2B 2.52 0 -1.27 0 MirTarget -0.23 0 NA
68 hsa-miR-20a-5p KAT2B 2.65 0 -1.27 0 MirTarget -0.24 0 NA
69 hsa-miR-25-3p KAT2B 0.36 0.01637 -1.27 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.29 0 NA
70 hsa-miR-32-5p KAT2B 0.88 6.0E-5 -1.27 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.14 0.00081 NA
71 hsa-miR-429 KAT2B 2.38 0 -1.27 0 miRanda -0.12 1.0E-5 NA
72 hsa-miR-450b-5p KAT2B 1.69 0 -1.27 0 MirTarget; miRNATAP -0.12 3.0E-5 NA
73 hsa-miR-576-5p KAT2B 1.03 0 -1.27 0 mirMAP -0.23 0 NA
74 hsa-miR-590-3p KAT2B 0.84 0.00129 -1.27 0 MirTarget; miRanda; mirMAP; miRNATAP -0.16 2.0E-5 NA
75 hsa-miR-590-5p KAT2B 2.07 0 -1.27 0 miRanda -0.32 0 NA
76 hsa-miR-92a-3p KAT2B -0.14 0.49341 -1.27 0 miRNAWalker2 validate; MirTarget -0.2 0 NA
77 hsa-miR-92b-3p KAT2B 0.05 0.83172 -1.27 0 MirTarget -0.12 0.00151 NA
78 hsa-miR-93-5p KAT2B 1.51 0 -1.27 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.3 0 NA
79 hsa-miR-129-5p LFNG -0.41 0.34149 0.77 0.00717 MirTarget -0.14 1.0E-5 NA
80 hsa-miR-365a-3p LFNG 0.01 0.9536 0.77 0.00717 mirMAP -0.22 0.00015 NA
81 hsa-miR-324-5p MAML2 1.07 5.0E-5 -1.13 1.0E-5 miRanda -0.27 0 NA
82 hsa-miR-330-5p MAML2 0.17 0.33643 -1.13 1.0E-5 miRanda -0.21 0.00184 NA
83 hsa-miR-421 MAML2 0.17 0.53528 -1.13 1.0E-5 miRanda -0.2 1.0E-5 NA
84 hsa-miR-429 MAML2 2.38 0 -1.13 1.0E-5 miRanda -0.12 0.00129 NA
85 hsa-miR-576-5p MAML2 1.03 0 -1.13 1.0E-5 mirMAP -0.29 0 NA
86 hsa-miR-590-3p MAML2 0.84 0.00129 -1.13 1.0E-5 mirMAP -0.23 2.0E-5 NA
87 hsa-miR-339-5p MAML3 0.54 0.04881 -0.65 0.00041 miRanda -0.11 0.00035 NA
88 hsa-miR-542-3p MAML3 1.62 0 -0.65 0.00041 miRanda -0.16 0 NA
89 hsa-miR-590-3p MAML3 0.84 0.00129 -0.65 0.00041 miRanda -0.23 0 NA
90 hsa-miR-2355-5p MFNG 1.86 0 -1.71 0 MirTarget -0.18 0 NA
91 hsa-miR-28-5p MFNG 1.2 0 -1.71 0 miRanda -0.32 0 NA
92 hsa-miR-590-3p MFNG 0.84 0.00129 -1.71 0 miRanda -0.13 0.00281 NA
93 hsa-miR-16-5p NCOR2 0.75 0 -0.22 0.13107 miRNAWalker2 validate; miRTarBase -0.15 0.00045 NA
94 hsa-miR-10a-5p NCSTN 0.79 0.00059 0.13 0.26094 miRNAWalker2 validate -0.11 0 NA
95 hsa-miR-28-5p NOTCH1 1.2 0 -1.08 0 miRanda -0.24 7.0E-5 NA
96 hsa-miR-106a-5p NOTCH2 1.39 6.0E-5 -0.12 0.49288 miRNAWalker2 validate -0.11 1.0E-5 NA
97 hsa-miR-15a-5p NOTCH2 1.63 0 -0.12 0.49288 MirTarget -0.14 0.00147 NA
98 hsa-miR-16-1-3p NOTCH2 1.5 0 -0.12 0.49288 mirMAP -0.11 0.00758 NA
99 hsa-miR-16-5p NOTCH2 0.75 0 -0.12 0.49288 miRNAWalker2 validate; MirTarget -0.18 0.00021 NA
100 hsa-miR-17-5p NOTCH2 2.07 0 -0.12 0.49288 miRNAWalker2 validate -0.2 0 NA
101 hsa-miR-181c-5p NOTCH2 0.53 0.01259 -0.12 0.49288 miRNAWalker2 validate; MirTarget -0.15 6.0E-5 26983574; 25494473 This is supported by the depletion of CTCF in glioblastoma cells affecting the expression levels of NOTCH2 as a target of miR-181c;Finally investigation of the mechanism defined Notch2 a key molecular of Notch signaling as the functional downstream target of miR-181c; An inverse correlation was found between miR-181c and Notch2 in glioma cells and verified in fresh glioma samples; miR-181c acts as a tumor suppressor that attenuates proliferation invasion and self-renewal capacities by downregulation of Notch2 in glioma cells
102 hsa-miR-181d-5p NOTCH2 1.19 0 -0.12 0.49288 MirTarget -0.17 1.0E-5 NA
103 hsa-miR-186-5p NOTCH2 0.85 0 -0.12 0.49288 mirMAP -0.2 0.0005 NA
104 hsa-miR-374a-5p NOTCH2 -0.2 0.29808 -0.12 0.49288 mirMAP -0.14 0.00275 NA
105 hsa-miR-590-3p NOTCH2 0.84 0.00129 -0.12 0.49288 miRanda -0.12 0.00146 NA
106 hsa-miR-590-5p NOTCH2 2.07 0 -0.12 0.49288 miRanda -0.11 0.00108 NA
107 hsa-miR-92a-3p NOTCH2 -0.14 0.49341 -0.12 0.49288 miRNAWalker2 validate -0.17 2.0E-5 NA
108 hsa-miR-150-5p NOTCH3 -0.7 0.02153 0.58 0.00527 miRNAWalker2 validate; miRTarBase -0.12 0.00011 NA
109 hsa-miR-335-5p NOTCH3 -0.47 0.0677 0.58 0.00527 miRNAWalker2 validate -0.14 0.00084 NA
110 hsa-miR-660-5p NOTCH3 2.05 0 0.58 0.00527 MirTarget -0.12 0.00354 NA
111 hsa-miR-421 NOTCH4 0.17 0.53528 -1.86 0 miRanda -0.15 7.0E-5 NA
112 hsa-miR-429 NOTCH4 2.38 0 -1.86 0 miRNATAP -0.12 9.0E-5 NA
113 hsa-miR-542-3p NOTCH4 1.62 0 -1.86 0 miRanda; miRNATAP -0.19 0 NA
114 hsa-let-7a-5p NUMBL -1.37 0 0.48 0.00621 TargetScan; miRNATAP -0.27 0 NA
115 hsa-let-7b-5p NUMBL -1.62 0 0.48 0.00621 miRNATAP -0.21 0 NA
116 hsa-let-7e-5p NUMBL -0.75 7.0E-5 0.48 0.00621 miRNATAP -0.12 0.00637 NA
117 hsa-let-7f-5p NUMBL -0.05 0.83408 0.48 0.00621 miRNATAP -0.17 0 NA
118 hsa-let-7g-5p NUMBL 0.08 0.58308 0.48 0.00621 miRNATAP -0.22 3.0E-5 NA
119 hsa-miR-186-5p PSEN1 0.85 0 -0.06 0.49081 mirMAP -0.14 0 NA
120 hsa-miR-664a-3p RBPJ 0.44 0.02142 0.07 0.55019 mirMAP -0.13 2.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 NOTCH SIGNALING PATHWAY 19 114 9.068e-37 4.219e-33
2 NOTCH RECEPTOR PROCESSING 9 16 8.084e-23 1.881e-19
3 POSITIVE REGULATION OF NOTCH SIGNALING PATHWAY 7 34 3.225e-14 5.001e-11
4 POSITIVE REGULATION OF GENE EXPRESSION 19 1733 5.142e-14 5.981e-11
5 MORPHOGENESIS OF AN EPITHELIUM 12 400 1.328e-13 1.236e-10
6 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 15 957 5.857e-13 3.216e-10
7 EPITHELIUM DEVELOPMENT 15 945 4.881e-13 3.216e-10
8 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 9 153 6.22e-13 3.216e-10
9 CELL FATE COMMITMENT 10 227 4.825e-13 3.216e-10
10 LYMPHOCYTE ACTIVATION 11 342 8.187e-13 3.809e-10
11 POSITIVE REGULATION OF CELL COMMUNICATION 17 1532 2.111e-12 7.556e-10
12 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 18 1805 1.91e-12 7.556e-10
13 ORGAN MORPHOGENESIS 14 841 2.093e-12 7.556e-10
14 TISSUE MORPHOGENESIS 12 533 3.9e-12 1.296e-09
15 EMBRYO DEVELOPMENT 14 894 4.769e-12 1.468e-09
16 REGULATION OF NOTCH SIGNALING PATHWAY 7 67 5.049e-12 1.468e-09
17 POSITIVE REGULATION OF RESPONSE TO STIMULUS 18 1929 5.917e-12 1.53e-09
18 LEUKOCYTE DIFFERENTIATION 10 292 5.917e-12 1.53e-09
19 LEUKOCYTE ACTIVATION 11 414 6.486e-12 1.588e-09
20 DNA TEMPLATED TRANSCRIPTION INITIATION 9 202 7.692e-12 1.79e-09
21 IMMUNE SYSTEM DEVELOPMENT 12 582 1.089e-11 2.203e-09
22 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 13 750 1.02e-11 2.203e-09
23 LYMPHOCYTE DIFFERENTIATION 9 209 1.045e-11 2.203e-09
24 HEART MORPHOGENESIS 9 212 1.188e-11 2.303e-09
25 CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT 5 16 1.925e-11 3.317e-09
26 CARDIOVASCULAR SYSTEM DEVELOPMENT 13 788 1.893e-11 3.317e-09
27 CIRCULATORY SYSTEM DEVELOPMENT 13 788 1.893e-11 3.317e-09
28 HEART DEVELOPMENT 11 466 2.316e-11 3.849e-09
29 TISSUE DEVELOPMENT 16 1518 2.951e-11 4.736e-09
30 MORPHOGENESIS OF AN EPITHELIAL SHEET 6 43 3.143e-11 4.876e-09
31 B CELL DIFFERENTIATION 7 89 3.917e-11 5.879e-09
32 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 16 1672 1.261e-10 1.833e-08
33 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 12 724 1.364e-10 1.923e-08
34 TUBE DEVELOPMENT 11 552 1.414e-10 1.935e-08
35 CELL ACTIVATION 11 568 1.916e-10 2.547e-08
36 PATTERN SPECIFICATION PROCESS 10 418 2.007e-10 2.595e-08
37 EAR DEVELOPMENT 8 195 2.547e-10 3.203e-08
38 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 16 1784 3.317e-10 4.062e-08
39 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 13 1004 3.816e-10 4.553e-08
40 TUBE MORPHOGENESIS 9 323 5.042e-10 5.722e-08
41 NEURON FATE COMMITMENT 6 67 5.025e-10 5.722e-08
42 B CELL ACTIVATION 7 132 6.426e-10 7.119e-08
43 SENSORY ORGAN DEVELOPMENT 10 493 9.952e-10 1.077e-07
44 EMBRYONIC MORPHOGENESIS 10 539 2.35e-09 2.486e-07
45 MATURE B CELL DIFFERENTIATION INVOLVED IN IMMUNE RESPONSE 4 13 2.525e-09 2.611e-07
46 SEGMENTATION 6 89 2.863e-09 2.896e-07
47 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 10 554 3.059e-09 2.91e-07
48 REGULATION OF NEURON DIFFERENTIATION 10 554 3.059e-09 2.91e-07
49 ENDOTHELIUM DEVELOPMENT 6 90 3.065e-09 2.91e-07
50 REGULATION OF BINDING 8 283 4.83e-09 4.406e-07
51 EPITHELIAL CELL FATE COMMITMENT 4 15 4.811e-09 4.406e-07
52 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 12 1021 6.804e-09 6.088e-07
53 CARDIAC CHAMBER MORPHOGENESIS 6 104 7.366e-09 6.467e-07
54 MATURE B CELL DIFFERENTIATION 4 17 8.372e-09 7.214e-07
55 ARTERY MORPHOGENESIS 5 51 9.995e-09 8.389e-07
56 REGIONALIZATION 8 311 1.01e-08 8.389e-07
57 REGULATION OF CELL DEVELOPMENT 11 836 1.106e-08 9.025e-07
58 REGULATION OF EMBRYONIC DEVELOPMENT 6 114 1.282e-08 1.028e-06
59 IMMUNE SYSTEM PROCESS 15 1984 1.693e-08 1.336e-06
60 NEURON DIFFERENTIATION 11 874 1.75e-08 1.357e-06
61 NEUROGENESIS 13 1402 2.193e-08 1.673e-06
62 SOMITOGENESIS 5 62 2.723e-08 2.044e-06
63 REGULATION OF CELL DIFFERENTIATION 13 1492 4.601e-08 3.398e-06
64 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 10 740 4.788e-08 3.428e-06
65 REGULATION OF CELL PROLIFERATION 13 1496 4.749e-08 3.428e-06
66 CARDIAC CHAMBER DEVELOPMENT 6 144 5.2e-08 3.666e-06
67 ENDOTHELIAL CELL DIFFERENTIATION 5 72 5.83e-08 4.048e-06
68 ARTERY DEVELOPMENT 5 75 7.169e-08 4.835e-06
69 AUDITORY RECEPTOR CELL DIFFERENTIATION 4 28 7.124e-08 4.835e-06
70 SOMITE DEVELOPMENT 5 78 8.743e-08 5.812e-06
71 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 10 801 1.006e-07 6.594e-06
72 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA 4 32 1.246e-07 8.053e-06
73 ANGIOGENESIS 7 293 1.596e-07 1.018e-05
74 HAIR CELL DIFFERENTIATION 4 35 1.809e-07 1.122e-05
75 B CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 4 35 1.809e-07 1.122e-05
76 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 12 1395 2.151e-07 1.317e-05
77 VASCULATURE DEVELOPMENT 8 469 2.398e-07 1.449e-05
78 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 6 191 2.775e-07 1.634e-05
79 LYMPHOCYTE ACTIVATION INVOLVED IN IMMUNE RESPONSE 5 98 2.757e-07 1.634e-05
80 ANTERIOR POSTERIOR PATTERN SPECIFICATION 6 194 3.041e-07 1.769e-05
81 CELL FATE DETERMINATION 4 43 4.23e-07 2.43e-05
82 VENTRICULAR TRABECULA MYOCARDIUM MORPHOGENESIS 3 11 4.487e-07 2.546e-05
83 SKIN DEVELOPMENT 6 211 4.982e-07 2.793e-05
84 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 5 111 5.135e-07 2.845e-05
85 REGULATION OF TIMING OF CELL DIFFERENTIATION 3 12 5.977e-07 3.234e-05
86 REGULATION OF DEVELOPMENT HETEROCHRONIC 3 12 5.977e-07 3.234e-05
87 BLOOD VESSEL MORPHOGENESIS 7 364 6.902e-07 3.691e-05
88 CARDIAC SEPTUM MORPHOGENESIS 4 49 7.218e-07 3.817e-05
89 MECHANORECEPTOR DIFFERENTIATION 4 51 8.497e-07 4.442e-05
90 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY INVOLVED IN NEURAL TUBE CLOSURE 3 14 9.87e-07 5.103e-05
91 POSITIVE REGULATION OF BINDING 5 127 1.002e-06 5.126e-05
92 SENSORY ORGAN MORPHOGENESIS 6 239 1.032e-06 5.22e-05
93 MAINTENANCE OF CELL NUMBER 5 132 1.214e-06 6.072e-05
94 N TERMINAL PROTEIN AMINO ACID ACETYLATION 3 15 1.233e-06 6.086e-05
95 OUTFLOW TRACT MORPHOGENESIS 4 56 1.243e-06 6.086e-05
96 EPIDERMIS DEVELOPMENT 6 253 1.437e-06 6.894e-05
97 EMBRYONIC ORGAN DEVELOPMENT 7 406 1.432e-06 6.894e-05
98 MORPHOGENESIS OF AN ENDOTHELIUM 3 16 1.516e-06 7.123e-05
99 LEUKOCYTE CELL CELL ADHESION 6 255 1.504e-06 7.123e-05
100 POSITIVE REGULATION OF CELL DIFFERENTIATION 9 823 1.544e-06 7.182e-05
101 CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 5 139 1.566e-06 7.216e-05
102 NEGATIVE REGULATION OF CELL DIFFERENTIATION 8 609 1.721e-06 7.849e-05
103 EPIDERMAL CELL DIFFERENTIATION 5 142 1.74e-06 7.862e-05
104 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 6 262 1.76e-06 7.876e-05
105 CARDIAC VENTRICLE MORPHOGENESIS 4 62 1.876e-06 8.313e-05
106 NEUROEPITHELIAL CELL DIFFERENTIATION 4 63 2.001e-06 8.784e-05
107 NEURAL TUBE DEVELOPMENT 5 149 2.206e-06 9.592e-05
108 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 7 437 2.333e-06 0.0001005
109 CELL DEVELOPMENT 11 1426 2.427e-06 0.0001036
110 EMBRYONIC ORGAN MORPHOGENESIS 6 279 2.533e-06 0.0001072
111 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 4 67 2.565e-06 0.0001075
112 NEURONAL STEM CELL POPULATION MAINTENANCE 3 19 2.615e-06 0.0001077
113 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 10 1142 2.615e-06 0.0001077
114 SKIN EPIDERMIS DEVELOPMENT 4 71 3.238e-06 0.000131
115 CELL FATE SPECIFICATION 4 71 3.238e-06 0.000131
116 COCHLEA MORPHOGENESIS 3 21 3.582e-06 0.0001437
117 POSITIVE REGULATION OF CELL DEVELOPMENT 7 472 3.881e-06 0.0001543
118 REGULATION OF PROTEIN BINDING 5 168 3.974e-06 0.0001567
119 NEGATIVE REGULATION OF CELL DEVELOPMENT 6 303 4.076e-06 0.000158
120 BETA CATENIN DESTRUCTION COMPLEX DISASSEMBLY 3 22 4.143e-06 0.000158
121 MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS 3 22 4.143e-06 0.000158
122 AORTA MORPHOGENESIS 3 22 4.143e-06 0.000158
123 RESPONSE TO OXYGEN LEVELS 6 311 4.734e-06 0.0001776
124 IMMUNE EFFECTOR PROCESS 7 486 4.703e-06 0.0001776
125 EPITHELIAL CELL DIFFERENTIATION 7 495 5.306e-06 0.0001975
126 CARDIAC SEPTUM DEVELOPMENT 4 85 6.654e-06 0.0002438
127 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 9 983 6.628e-06 0.0002438
128 HEART TRABECULA MORPHOGENESIS 3 26 6.968e-06 0.0002513
129 N TERMINAL PROTEIN AMINO ACID MODIFICATION 3 26 6.968e-06 0.0002513
130 TISSUE REMODELING 4 87 7.3e-06 0.0002613
131 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER INVOLVED IN CELLULAR RESPONSE TO CHEMICAL STIMULUS 3 27 7.832e-06 0.0002782
132 REGULATION OF SPROUTING ANGIOGENESIS 3 28 8.763e-06 0.0003089
133 CANONICAL WNT SIGNALING PATHWAY 4 95 1.036e-05 0.0003624
134 CARDIAC ATRIUM DEVELOPMENT 3 31 1.199e-05 0.0004163
135 ENDOCARDIAL CUSHION DEVELOPMENT 3 32 1.322e-05 0.0004522
136 BLOOD VESSEL REMODELING 3 32 1.322e-05 0.0004522
137 CARDIAC VENTRICLE DEVELOPMENT 4 106 1.599e-05 0.000539
138 HEART VALVE DEVELOPMENT 3 34 1.591e-05 0.000539
139 IMMUNE RESPONSE 9 1100 1.641e-05 0.0005493
140 MEMBRANE PROTEIN PROTEOLYSIS 3 35 1.739e-05 0.0005779
141 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 5 232 1.903e-05 0.0006281
142 CELL CELL ADHESION 7 608 2.02e-05 0.0006618
143 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 5 236 2.066e-05 0.0006631
144 MYOBLAST DIFFERENTIATION 3 37 2.06e-05 0.0006631
145 NEGATIVE REGULATION OF EPITHELIAL CELL DIFFERENTIATION 3 37 2.06e-05 0.0006631
146 POSITIVE REGULATION OF GROWTH 5 238 2.152e-05 0.0006858
147 REGULATION OF NEURON PROJECTION DEVELOPMENT 6 408 2.217e-05 0.000697
148 NEPHRON DEVELOPMENT 4 115 2.205e-05 0.000697
149 REGULATION OF ORGAN MORPHOGENESIS 5 242 2.331e-05 0.000728
150 TRABECULA MORPHOGENESIS 3 39 2.419e-05 0.0007453
151 COCHLEA DEVELOPMENT 3 39 2.419e-05 0.0007453
152 NEGATIVE REGULATION OF GENE EXPRESSION 10 1493 2.798e-05 0.0008562
153 AORTA DEVELOPMENT 3 41 2.816e-05 0.0008562
154 T CELL DIFFERENTIATION 4 123 2.872e-05 0.0008678
155 NEGATIVE REGULATION OF CELL PROLIFERATION 7 643 2.893e-05 0.0008684
156 MUSCLE STRUCTURE DEVELOPMENT 6 432 3.057e-05 0.0009117
157 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 10 1517 3.212e-05 0.000952
158 TUBE FORMATION 4 129 3.462e-05 0.00102
159 VENTRICULAR CARDIAC MUSCLE TISSUE DEVELOPMENT 3 45 3.733e-05 0.001093
160 MORPHOGENESIS OF EMBRYONIC EPITHELIUM 4 134 4.018e-05 0.001168
161 MUSCLE TISSUE DEVELOPMENT 5 275 4.295e-05 0.001234
162 SINGLE ORGANISM CELL ADHESION 6 459 4.29e-05 0.001234
163 MUSCLE ORGAN DEVELOPMENT 5 277 4.446e-05 0.001269
164 GLOMERULUS DEVELOPMENT 3 49 4.828e-05 0.00137
165 CELLULAR RESPONSE TO OXYGEN LEVELS 4 143 5.179e-05 0.001461
166 RHYTHMIC PROCESS 5 298 6.289e-05 0.001763
167 CARDIAC MUSCLE TISSUE MORPHOGENESIS 3 54 6.469e-05 0.001802
168 REGULATION OF MUSCLE CELL DIFFERENTIATION 4 152 6.569e-05 0.001819
169 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 5 303 6.804e-05 0.001873
170 POSITIVE REGULATION OF NEURON DIFFERENTIATION 5 306 7.128e-05 0.001951
171 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 3 56 7.215e-05 0.001963
172 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 4 156 7.266e-05 0.001966
173 REGULATION OF WNT SIGNALING PATHWAY 5 310 7.579e-05 0.002038
174 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 6 513 7.95e-05 0.002126
175 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 4 162 8.412e-05 0.002224
176 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 4 162 8.412e-05 0.002224
177 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 9 1360 8.728e-05 0.002294
178 REGULATION OF PROTEIN TYROSINE KINASE ACTIVITY 3 61 9.322e-05 0.002423
179 EMBRYONIC DIGIT MORPHOGENESIS 3 61 9.322e-05 0.002423
180 EMBRYONIC HEART TUBE MORPHOGENESIS 3 62 9.787e-05 0.00253
181 APPENDAGE DEVELOPMENT 4 169 9.909e-05 0.002533
182 LIMB DEVELOPMENT 4 169 9.909e-05 0.002533
183 REGULATION OF PROTEIN ACETYLATION 3 64 0.0001076 0.002736
184 LOOP OF HENLE DEVELOPMENT 2 11 0.0001108 0.002741
185 ENDOCARDIUM DEVELOPMENT 2 11 0.0001108 0.002741
186 NEGATIVE REGULATION OF SPROUTING ANGIOGENESIS 2 11 0.0001108 0.002741
187 EPITHELIAL TO MESENCHYMAL TRANSITION INVOLVED IN ENDOCARDIAL CUSHION FORMATION 2 11 0.0001108 0.002741
188 ENDOTHELIAL TUBE MORPHOGENESIS 2 11 0.0001108 0.002741
189 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 5 337 0.0001123 0.002764
190 COVALENT CHROMATIN MODIFICATION 5 345 0.0001253 0.003069
191 REGULATION OF CELL PROJECTION ORGANIZATION 6 558 0.0001262 0.003074
192 POSITIVE REGULATION OF CELL PROLIFERATION 7 814 0.0001283 0.003109
193 REGULATION OF CYTOKINE PRODUCTION 6 563 0.0001325 0.003136
194 CARDIAC LEFT VENTRICLE MORPHOGENESIS 2 12 0.0001328 0.003136
195 AMYLOID PRECURSOR PROTEIN METABOLIC PROCESS 2 12 0.0001328 0.003136
196 POSITIVE REGULATION OF MOLECULAR FUNCTION 10 1791 0.0001319 0.003136
197 DISTAL TUBULE DEVELOPMENT 2 12 0.0001328 0.003136
198 MUSCLE ORGAN MORPHOGENESIS 3 70 0.0001406 0.003303
199 EPITHELIAL CELL DEVELOPMENT 4 186 0.0001434 0.003353
200 FOREBRAIN DEVELOPMENT 5 357 0.0001471 0.003421
201 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 8 1135 0.0001544 0.003574
202 LEFT RIGHT AXIS SPECIFICATION 2 13 0.0001568 0.003576
203 CARDIOBLAST DIFFERENTIATION 2 13 0.0001568 0.003576
204 NEGATIVE REGULATION OF EPIDERMAL CELL DIFFERENTIATION 2 13 0.0001568 0.003576
205 POSITIVE REGULATION OF PROTEIN BINDING 3 73 0.0001592 0.003597
206 EMBRYONIC HEART TUBE DEVELOPMENT 3 73 0.0001592 0.003597
207 REGULATION OF CELL DEATH 9 1472 0.0001603 0.003604
208 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 8 1152 0.0001711 0.003827
209 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 9 1492 0.0001777 0.003956
210 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 4 197 0.0001788 0.003962
211 BETA AMYLOID METABOLIC PROCESS 2 14 0.0001828 0.004011
212 CONVERGENT EXTENSION 2 14 0.0001828 0.004011
213 RENAL TUBULE DEVELOPMENT 3 78 0.0001938 0.004234
214 CENTRAL NERVOUS SYSTEM DEVELOPMENT 7 872 0.0001965 0.004273
215 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 7 876 0.0002021 0.004375
216 RESPONSE TO MURAMYL DIPEPTIDE 2 15 0.0002107 0.004497
217 ENDOCARDIAL CUSHION FORMATION 2 15 0.0002107 0.004497
218 REGULATION OF CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS 2 15 0.0002107 0.004497
219 NEGATIVE REGULATION OF CELL COMMUNICATION 8 1192 0.0002164 0.004598
220 REGULATION OF ERBB SIGNALING PATHWAY 3 83 0.0002329 0.004882
221 HAIR CYCLE 3 83 0.0002329 0.004882
222 MOLTING CYCLE 3 83 0.0002329 0.004882
223 GLAND DEVELOPMENT 5 395 0.0002354 0.004911
224 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 4 213 0.000241 0.004941
225 CARDIAC RIGHT VENTRICLE MORPHOGENESIS 2 16 0.0002406 0.004941
226 NEGATIVE REGULATION OF EPIDERMIS DEVELOPMENT 2 16 0.0002406 0.004941
227 APOPTOTIC PROCESS INVOLVED IN MORPHOGENESIS 2 16 0.0002406 0.004941
228 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 3 85 0.0002499 0.0051
229 REGULATION OF CHROMATIN BINDING 2 17 0.0002724 0.005487
230 MEMBRANE PROTEIN INTRACELLULAR DOMAIN PROTEOLYSIS 2 17 0.0002724 0.005487
231 SEGMENT SPECIFICATION 2 17 0.0002724 0.005487
232 PERICARDIUM DEVELOPMENT 2 18 0.0003062 0.00614
233 INNER EAR MORPHOGENESIS 3 92 0.0003156 0.006303
234 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 4 229 0.0003176 0.006315
235 NEPHRON EPITHELIUM DEVELOPMENT 3 93 0.0003258 0.006451
236 KIDNEY VASCULATURE DEVELOPMENT 2 19 0.0003419 0.006628
237 REGULATION OF CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS 2 19 0.0003419 0.006628
238 POSITIVE REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 2 19 0.0003419 0.006628
239 RENAL SYSTEM VASCULATURE DEVELOPMENT 2 19 0.0003419 0.006628
240 NEURAL TUBE FORMATION 3 94 0.0003362 0.006628
241 CELL PROLIFERATION 6 672 0.0003451 0.006663
242 CARDIOCYTE DIFFERENTIATION 3 96 0.0003577 0.006877
243 MEMORY 3 98 0.00038 0.007247
244 MYELOID DENDRITIC CELL DIFFERENTIATION 2 20 0.0003795 0.007247
245 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 3 100 0.0004032 0.007658
246 KERATINOCYTE DIFFERENTIATION 3 101 0.0004152 0.007853
247 LEFT RIGHT PATTERN FORMATION 2 21 0.0004191 0.007863
248 APOPTOTIC PROCESS INVOLVED IN DEVELOPMENT 2 21 0.0004191 0.007863
249 REGULATION OF MUSCLE TISSUE DEVELOPMENT 3 103 0.0004397 0.008184
250 REGULATION OF MUSCLE ORGAN DEVELOPMENT 3 103 0.0004397 0.008184
251 ENDOCARDIAL CUSHION MORPHOGENESIS 2 22 0.0004606 0.008471
252 HEAD DEVELOPMENT 6 709 0.0004592 0.008471
253 SOMATIC STEM CELL DIVISION 2 22 0.0004606 0.008471
254 SPINAL CORD DEVELOPMENT 3 106 0.0004783 0.008762
255 REGULATION OF EPIDERMAL GROWTH FACTOR ACTIVATED RECEPTOR ACTIVITY 2 23 0.000504 0.00909
256 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 2 23 0.000504 0.00909
257 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO STRESS 2 23 0.000504 0.00909
258 POSITIVE REGULATION OF COLLAGEN METABOLIC PROCESS 2 23 0.000504 0.00909
259 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 5 470 0.0005227 0.00939
260 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 3 110 0.000533 0.009538
261 NEGATIVE REGULATION OF BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 2 24 0.0005493 0.009609
262 NEGATIVE REGULATION OF MYOBLAST DIFFERENTIATION 2 24 0.0005493 0.009609
263 EPITHELIAL CELL DIFFERENTIATION INVOLVED IN KIDNEY DEVELOPMENT 2 24 0.0005493 0.009609
264 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 2 24 0.0005493 0.009609
265 REGULATION OF TYPE I INTERFERON PRODUCTION 3 111 0.0005473 0.009609
266 BIOLOGICAL ADHESION 7 1032 0.0005476 0.009609
267 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 7 1036 0.0005605 0.009717
268 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 7 1036 0.0005605 0.009717
269 EAR MORPHOGENESIS 3 112 0.0005618 0.009717
270 REGULATION OF STEM CELL DIFFERENTIATION 3 113 0.0005765 0.009936
NumGOOverlapSizeP ValueAdj. P Value
1 NOTCH BINDING 7 18 1.937e-16 1.8e-13
2 RECEPTOR BINDING 13 1476 4.048e-08 1.88e-05
3 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 9 588 9.14e-08 2.83e-05
4 TRANSCRIPTION FACTOR BINDING 8 524 5.562e-07 0.0001292
5 CHROMATIN BINDING 7 435 2.264e-06 0.0004206
6 TRANSCRIPTION COACTIVATOR ACTIVITY 6 296 3.563e-06 0.0005517
7 CALCIUM ION BINDING 8 697 4.685e-06 0.0006217
8 BETA CATENIN BINDING 4 84 6.347e-06 0.0007371
9 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 4 104 1.483e-05 0.00153
10 FRIZZLED BINDING 3 36 1.895e-05 0.00176
11 RAC GTPASE BINDING 3 39 2.419e-05 0.002043
12 CORE PROMOTER BINDING 4 152 6.569e-05 0.005085
13 PEPTIDE N ACETYLTRANSFERASE ACTIVITY 3 67 0.0001234 0.008816
NumGOOverlapSizeP ValueAdj. P Value
1 CHROMATIN 6 441 3.431e-05 0.008203
2 NUCLEAR CHROMATIN 5 291 5.619e-05 0.008203
3 NUCLEOPLASM PART 7 708 5.342e-05 0.008203
4 GOLGI MEMBRANE 7 703 5.107e-05 0.008203

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04330_Notch_signaling_pathway 29 47 7.679e-82 1.382e-79
2 hsa04310_Wnt_signaling_pathway 7 151 1.651e-09 1.486e-07
3 hsa04320_Dorso.ventral_axis_formation 4 25 4.414e-08 2.649e-06
4 hsa04916_Melanogenesis 5 101 3.206e-07 1.443e-05
5 hsa04110_Cell_cycle 3 128 0.0008284 0.02982
6 hsa04390_Hippo_signaling_pathway 3 154 0.001412 0.04237
7 hsa00514_Other_types_of_O.glycan_biosynthesis 2 46 0.00202 0.05193
8 hsa04720_Long.term_potentiation 2 70 0.004612 0.1001
9 hsa04520_Adherens_junction 2 73 0.005006 0.1001
10 hsa04350_TGF.beta_signaling_pathway 2 85 0.006727 0.1211
11 hsa04630_Jak.STAT_signaling_pathway 2 155 0.02113 0.3457

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 LINC00968 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-450b-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-93-5p 12 KAT2B Sponge network -4.19 0 -1.267 0 0.516
2 RP11-399O19.9 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-429;hsa-miR-576-5p;hsa-miR-93-5p 10 KAT2B Sponge network -0.873 0.00072 -1.267 0 0.51
3 RP11-389C8.2 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-93-5p 10 KAT2B Sponge network -2.039 0 -1.267 0 0.445
4 RP11-354E11.2 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-576-5p;hsa-miR-590-3p 10 KAT2B Sponge network -2.138 0 -1.267 0 0.434
5 MAGI2-AS3 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-429;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-93-5p 15 KAT2B Sponge network -1.892 0 -1.267 0 0.431
6 CTD-2008P7.9 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p 10 KAT2B Sponge network -1.912 1.0E-5 -1.267 0 0.43
7 WDFY3-AS2 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p 10 KAT2B Sponge network -1.297 0 -1.267 0 0.429
8 RP11-1024P17.1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-429;hsa-miR-576-5p;hsa-miR-590-3p 11 KAT2B Sponge network -2.062 0 -1.267 0 0.428
9 RP11-532F6.3 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181d-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-576-5p 10 KAT2B Sponge network -2.028 0 -1.267 0 0.421
10 RP11-1008C21.1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181d-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-590-3p 10 KAT2B Sponge network -1.826 3.0E-5 -1.267 0 0.408
11 RP11-284N8.3 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-576-5p;hsa-miR-590-5p;hsa-miR-93-5p 11 KAT2B Sponge network -0.761 0.05061 -1.267 0 0.404
12 TBX5-AS1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-450b-5p;hsa-miR-576-5p;hsa-miR-590-5p;hsa-miR-92a-3p;hsa-miR-92b-3p 14 KAT2B Sponge network -2.108 0 -1.267 0 0.398
13 AC109642.1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-590-3p;hsa-miR-92a-3p;hsa-miR-93-5p 12 KAT2B Sponge network -2.791 0 -1.267 0 0.394
14 FENDRR hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-450b-5p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-93-5p 11 KAT2B Sponge network -4.222 0 -1.267 0 0.393
15 PCED1B-AS1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-429;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-93-5p 12 KAT2B Sponge network -0.672 0.02084 -1.267 0 0.381
16

LINC00702

 hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-186-5p;hsa-miR-200c-3p;hsa-miR-21-5p;hsa-miR-335-3p;hsa-miR-34a-5p;hsa-miR-450b-5p;hsa-miR-590-5p;hsa-miR-628-5p 10 JAG1 Sponge network -2.856 0 -0.943 0.0001 0.359
17 HLA-F-AS1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181d-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-590-5p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-93-5p 14 KAT2B Sponge network -0.495 0.12126 -1.267 0 0.353
18 CASC2 hsa-miR-106a-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-93-5p 10 KAT2B Sponge network -1.086 0 -1.267 0 0.352
19 RP11-378A13.1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-590-3p;hsa-miR-93-5p 10 KAT2B Sponge network -1.713 0 -1.267 0 0.338
20

LINC00702

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-450b-5p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-93-5p 16 KAT2B Sponge network -2.856 0 -1.267 0 0.322
21 MIR497HG hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-590-5p;hsa-miR-93-5p 10 KAT2B Sponge network -2.142 0 -1.267 0 0.312
22 CTD-2013N24.2 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-429;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-93-5p 11 KAT2B Sponge network -1.745 0 -1.267 0 0.305
23 AC004947.2 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-450b-5p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-93-5p 10 KAT2B Sponge network -3.94 0 -1.267 0 0.302
24 LINC01010 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181d-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-429;hsa-miR-93-5p 10 KAT2B Sponge network -0.54 0.27666 -1.267 0 0.293
25 RP11-166D19.1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-429;hsa-miR-590-5p;hsa-miR-92a-3p;hsa-miR-92b-3p 13 KAT2B Sponge network -0.582 0.05253 -1.267 0 0.272
26 RP11-283G6.4 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181d-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-450b-5p;hsa-miR-93-5p 10 KAT2B Sponge network -3.669 1.0E-5 -1.267 0 0.268
27 GAS6-AS2 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-429;hsa-miR-590-5p;hsa-miR-92a-3p 11 KAT2B Sponge network -1.761 0 -1.267 0 0.263

Quest ID: 3b7f5f9971218f723c4d66e8422acc7d