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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-141-3p ABL1 -5.02 0 1.32 0 MirTarget -0.18 0 NA
2 hsa-miR-141-3p ABL2 -5.02 0 0.32 0.04554 MirTarget; TargetScan; miRNATAP -0.13 0 NA
3 hsa-miR-141-3p ACO1 -5.02 0 0.65 0.00055 MirTarget; TargetScan -0.13 0 NA
4 hsa-miR-141-3p ADARB1 -5.02 0 1.93 0 MirTarget -0.34 0 NA
5 hsa-miR-141-3p AFAP1 -5.02 0 0.98 0.00012 mirMAP -0.24 0 NA
6 hsa-miR-141-3p AKAP2 -5.02 0 2.51 8.0E-5 TargetScan -0.59 0 NA
7 hsa-miR-141-3p AMOTL1 -5.02 0 1.62 0 TargetScan -0.26 0 NA
8 hsa-miR-141-3p AMZ1 -5.02 0 -0.48 0.33638 mirMAP -0.17 0.00019 NA
9 hsa-miR-141-3p ANGPTL1 -5.02 0 4.51 0 MirTarget -0.76 0 NA
10 hsa-miR-141-3p ANK2 -5.02 0 4.32 0 TargetScan; miRNATAP -0.68 0 NA
11 hsa-miR-141-3p ANKRD44 -5.02 0 1.93 0 TargetScan -0.35 0 NA
12 hsa-miR-141-3p ANO5 -5.02 0 3.19 0 mirMAP -0.3 0 NA
13 hsa-miR-141-3p APBB2 -5.02 0 0.59 0.0014 MirTarget; TargetScan -0.17 0 NA
14 hsa-miR-141-3p APOLD1 -5.02 0 2.62 0 TargetScan -0.24 0 NA
15 hsa-miR-141-3p ARHGAP24 -5.02 0 2.02 0 TargetScan; miRNATAP -0.38 0 NA
16 hsa-miR-141-3p ARID5B -5.02 0 1.57 0 TargetScan; miRNATAP -0.16 0 NA
17 hsa-miR-141-3p ARL10 -5.02 0 1.12 0.00198 mirMAP -0.25 0 NA
18 hsa-miR-141-3p ARL4A -5.02 0 0.62 0.01525 TargetScan -0.1 1.0E-5 NA
19 hsa-miR-141-3p ARNT2 -5.02 0 1.45 0.00019 mirMAP -0.13 0.00022 NA
20 hsa-miR-141-3p ARNTL -5.02 0 0.36 0.08956 MirTarget; TargetScan; miRNATAP -0.1 0 NA
21 hsa-miR-141-3p ASB1 -5.02 0 0.87 0 mirMAP -0.12 0 NA
22 hsa-miR-141-3p ASTN1 -5.02 0 2.34 2.0E-5 MirTarget; miRNATAP -0.14 0.00582 NA
23 hsa-miR-141-3p ASXL3 -5.02 0 3.34 0 TargetScan -0.31 0 NA
24 hsa-miR-141-3p ATP8A1 -5.02 0 1.48 8.0E-5 MirTarget; TargetScan -0.16 1.0E-5 NA
25 hsa-miR-141-3p ATXN1 -5.02 0 1.51 0 MirTarget; TargetScan; miRNATAP -0.24 0 NA
26 hsa-miR-141-3p BACE1 -5.02 0 0.72 0.00096 TargetScan; miRNATAP -0.22 0 NA
27 hsa-miR-141-3p BACH2 -5.02 0 1.52 0.00134 TargetScan -0.49 0 NA
28 hsa-miR-210-3p BDNF -6.07 0 2.91 0 miRNAWalker2 validate; miRTarBase -0.24 0 NA
29 hsa-miR-141-3p BEND4 -5.02 0 1.97 7.0E-5 TargetScan; miRNATAP -0.29 0 NA
30 hsa-miR-141-3p BNC2 -5.02 0 2.95 0 TargetScan -0.63 0 NA
31 hsa-miR-141-3p BVES -5.02 0 2.76 0 mirMAP -0.48 0 NA
32 hsa-miR-141-3p C11orf21 -5.02 0 1.31 0.00227 mirMAP -0.24 0 NA
33 hsa-miR-141-3p CACNA2D1 -5.02 0 3.32 0 TargetScan -0.71 0 NA
34 hsa-miR-141-3p CADM1 -5.02 0 1.19 0.01251 MirTarget; TargetScan -0.16 0.00033 NA
35 hsa-miR-141-3p CADM2 -5.02 0 3.84 0 TargetScan; miRNATAP -0.3 0 NA
36 hsa-miR-141-3p CALU -5.02 0 0.15 0.46318 TargetScan -0.2 0 NA
37 hsa-miR-141-3p CAMK4 -5.02 0 1.28 0.0022 mirMAP -0.29 0 NA
38 hsa-miR-141-3p CCDC80 -5.02 0 3.33 0 MirTarget; TargetScan -0.69 0 NA
39 hsa-miR-141-3p CCND2 -5.02 0 2.43 0 MirTarget; TargetScan -0.34 0 NA
40 hsa-miR-141-3p CCPG1 -5.02 0 1 0 MirTarget; miRNATAP -0.19 0 NA
41 hsa-miR-141-3p CD274 -5.02 0 -0.06 0.90454 MirTarget -0.22 0 NA
42 hsa-miR-141-3p CD59 -5.02 0 0.7 0.0013 mirMAP -0.1 0 NA
43 hsa-miR-141-3p CDC25B -5.02 0 -0.78 0.00479 TargetScan -0.12 0 NA
44 hsa-miR-141-3p CDC42EP3 -5.02 0 1.35 0 MirTarget; TargetScan -0.22 0 NA
45 hsa-miR-141-3p CDK6 -5.02 0 0.77 0.06479 TargetScan; miRNATAP -0.28 0 NA
46 hsa-miR-141-3p CDON -5.02 0 2.61 0 TargetScan; miRNATAP -0.4 0 NA
47 hsa-miR-141-3p CDV3 -5.02 0 0.42 0.0021 TargetScan; miRNATAP -0.11 0 NA
48 hsa-miR-141-3p CELF2 -5.02 0 3.05 0 mirMAP; miRNATAP -0.47 0 NA
49 hsa-miR-141-3p CEP170 -5.02 0 0.11 0.58268 TargetScan -0.14 0 NA
50 hsa-miR-141-3p CFL2 -5.02 0 2.62 0 TargetScan -0.42 0 NA
51 hsa-miR-141-3p CHRDL1 -5.02 0 6.15 0 MirTarget; TargetScan -0.9 0 NA
52 hsa-miR-141-3p CLIC4 -5.02 0 1.72 0 MirTarget -0.4 0 NA
53 hsa-miR-141-3p CLIP2 -5.02 0 0.8 0.00158 MirTarget; TargetScan -0.15 0 NA
54 hsa-miR-141-3p CNTN1 -5.02 0 4.98 0 MirTarget; TargetScan; miRNATAP -0.75 0 NA
55 hsa-miR-141-3p COL11A1 -5.02 0 -4.69 0 miRNATAP -0.23 0.00397 NA
56 hsa-miR-141-3p COL15A1 -5.02 0 0.94 0.00988 MirTarget -0.34 0 NA
57 hsa-miR-141-3p COL8A1 -5.02 0 0.75 0.115 mirMAP -0.38 0 NA
58 hsa-miR-141-3p CORO1C -5.02 0 1.12 0 TargetScan -0.25 0 NA
59 hsa-miR-210-3p CORO2B -6.07 0 2.03 0 MirTarget -0.22 0 NA
60 hsa-miR-141-3p CPEB4 -5.02 0 1.56 0 TargetScan -0.12 0 NA
61 hsa-miR-141-3p CREB5 -5.02 0 2.28 0 mirMAP -0.41 0 NA
62 hsa-miR-141-3p CRMP1 -5.02 0 1.11 0.00158 MirTarget; TargetScan -0.23 0 NA
63 hsa-miR-141-3p CSF3 -5.02 0 4.55 0 TargetScan; miRNATAP -0.54 0 NA
64 hsa-miR-141-3p CTSB -5.02 0 -0.1 0.67673 mirMAP -0.17 0 NA
65 hsa-miR-141-3p CTTNBP2 -5.02 0 2.9 1.0E-5 miRNATAP -0.24 7.0E-5 NA
66 hsa-miR-141-3p CXCL12 -5.02 0 3.26 0 miRNATAP -0.58 0 NA
67 hsa-miR-141-3p CYLD -5.02 0 0.89 0 mirMAP -0.14 0 NA
68 hsa-miR-141-3p CYP26B1 -5.02 0 0.69 0.15191 MirTarget; TargetScan; miRNATAP -0.38 0 NA
69 hsa-miR-141-3p DIO2 -5.02 0 0.24 0.63454 miRNATAP -0.29 0 NA
70 hsa-miR-141-3p DLC1 -5.02 0 1.8 0 TargetScan; miRNATAP -0.21 0 26278151 MicroRNA 141 regulates the tumour suppressor DLC1 in colorectal cancer; Luciferase reporter assays and Western blots showed that DLC1 was a direct target of miR-141 in CRC; The expression levels of miR-141 were obviously up-regulated in CRC tissues compared to non-cancerous tissues while DLC1 expression levels were down-regulated in a high proportion of clinical samples 14/18; In addition correlation analyses revealed negative correlation between miR-141 levels and DLC1 expression levels in CRC tissues; In conclusion we demonstrated that miR-141 is up-regulated in CRC and acts as a functional oncogene by targeting DLC1
71 hsa-miR-141-3p DOCK4 -5.02 0 0.48 0.07912 MirTarget; TargetScan -0.18 0 NA
72 hsa-miR-141-3p DPYSL3 -5.02 0 2.32 0 TargetScan -0.54 0 NA
73 hsa-miR-141-3p DSEL -5.02 0 1.79 0 TargetScan -0.29 0 NA
74 hsa-miR-141-3p DST -5.02 0 1.12 9.0E-5 mirMAP -0.12 0 NA
75 hsa-miR-141-3p DUSP1 -5.02 0 3.47 0 TargetScan -0.34 0 NA
76 hsa-miR-141-3p DUSP3 -5.02 0 1.04 0 MirTarget; TargetScan; miRNATAP -0.15 0 NA
77 hsa-miR-141-3p DYNC1I1 -5.02 0 2.05 0.0001 MirTarget -0.21 1.0E-5 NA
78 hsa-miR-141-3p DZIP1 -5.02 0 1.57 2.0E-5 TargetScan; miRNATAP -0.29 0 NA
79 hsa-miR-141-3p EGR2 -5.02 0 2.81 0 TargetScan; miRNATAP -0.47 0 NA
80 hsa-miR-210-3p ELFN2 -6.07 0 0.56 0.36612 MirTarget -0.17 0.00076 NA
81 hsa-miR-141-3p ELK3 -5.02 0 0.31 0.25641 TargetScan -0.19 0 NA
82 hsa-miR-141-3p ELL2 -5.02 0 1.08 1.0E-5 TargetScan -0.13 0 NA
83 hsa-miR-141-3p ENAH -5.02 0 0.68 0.00063 TargetScan -0.15 0 NA
84 hsa-miR-141-3p EPB41L3 -5.02 0 1.63 7.0E-5 miRNATAP -0.29 0 NA
85 hsa-miR-141-3p EPHA7 -5.02 0 4.2 0 TargetScan; miRNATAP -0.33 0 26261572 Among those the expression of EPHA7 and PI15 were negatively correlated with that of microRNA-141 and they were also identified as potential targets of this microRNA via microRNA-mRNA interaction; We thus concluded that microRNA-141 EPHA7 and PI15 might jointly participate in the regulation of drug resistance in ovarian cancer and serve as potential targets in targeted therapies
86 hsa-miR-141-3p ERC2 -5.02 0 0.08 0.86617 MirTarget; TargetScan -0.11 0.01934 NA
87 hsa-miR-141-3p ERG -5.02 0 1.35 0 MirTarget; TargetScan -0.25 0 NA
88 hsa-miR-141-3p ETS1 -5.02 0 0.7 0.00228 mirMAP -0.14 0 NA
89 hsa-miR-141-3p FAM133A -5.02 0 0.54 0.49453 mirMAP -0.31 1.0E-5 NA
90 hsa-miR-141-3p FAM167A -5.02 0 -0.27 0.48779 mirMAP -0.19 0 NA
91 hsa-miR-141-3p FAM168A -5.02 0 0.72 0.00481 TargetScan -0.17 0 NA
92 hsa-miR-141-3p FAM168B -5.02 0 0.95 0 MirTarget; TargetScan -0.11 0 NA
93 hsa-miR-141-3p FAM20C -5.02 0 1.33 0.00181 MirTarget -0.46 0 NA
94 hsa-miR-141-3p FAM26E -5.02 0 1.51 4.0E-5 mirMAP -0.41 0 NA
95 hsa-miR-141-3p FAM46C -5.02 0 1.66 0 TargetScan; miRNATAP -0.11 0.00024 NA
96 hsa-miR-141-3p FAT3 -5.02 0 2.79 0 MirTarget; miRNATAP -0.24 1.0E-5 NA
97 hsa-miR-141-3p FER -5.02 0 0.96 0.00017 mirMAP -0.18 0 NA
98 hsa-miR-141-3p FGF13 -5.02 0 2.8 0 TargetScan -0.3 0 NA
99 hsa-miR-141-3p FKBP5 -5.02 0 1.54 4.0E-5 TargetScan -0.39 0 NA
100 hsa-miR-141-3p FLI1 -5.02 0 1.11 7.0E-5 TargetScan -0.28 0 NA
101 hsa-miR-141-3p FNIP2 -5.02 0 0.76 0.01045 TargetScan -0.15 0 NA
102 hsa-miR-141-3p FOXN3 -5.02 0 1.44 0 MirTarget; TargetScan; miRNATAP -0.14 0 NA
103 hsa-miR-141-3p FOXP2 -5.02 0 3.99 0 TargetScan -0.49 0 NA
104 hsa-miR-141-3p FRMD6 -5.02 0 0.93 0.00183 MirTarget; TargetScan; miRNATAP -0.12 2.0E-5 NA
105 hsa-miR-141-3p FSD1L -5.02 0 0.15 0.71855 TargetScan -0.29 0 NA
106 hsa-miR-141-3p FTO -5.02 0 0.52 0.0001 mirMAP -0.1 0 NA
107 hsa-miR-141-3p FYCO1 -5.02 0 1.62 0 mirMAP -0.12 0 NA
108 hsa-miR-141-3p FZD4 -5.02 0 0.83 0.00068 TargetScan -0.11 0 NA
109 hsa-miR-141-3p GAB2 -5.02 0 1.2 0 mirMAP -0.13 0 NA
110 hsa-miR-141-3p GATA6 -5.02 0 3.38 0 TargetScan; miRNATAP -0.51 0 NA
111 hsa-miR-141-3p GCNT2 -5.02 0 0.71 0.08266 TargetScan -0.11 0.00337 NA
112 hsa-miR-141-3p GDF6 -5.02 0 1.14 0.02791 TargetScan -0.34 0 NA
113 hsa-miR-141-3p GEM -5.02 0 3.69 0 MirTarget -0.59 0 NA
114 hsa-miR-141-3p GFRA1 -5.02 0 5 0 mirMAP -0.39 0 NA
115 hsa-miR-141-3p GFRA2 -5.02 0 3.22 0 mirMAP -0.44 0 NA
116 hsa-miR-141-3p GJC1 -5.02 0 0.97 0.00222 MirTarget; TargetScan; miRNATAP -0.25 0 NA
117 hsa-miR-141-3p GLI2 -5.02 0 2.29 0 MirTarget -0.49 0 NA
118 hsa-miR-141-3p GLRX -5.02 0 0.28 0.31677 MirTarget; TargetScan; miRNATAP -0.13 0 NA
119 hsa-miR-141-3p GNA12 -5.02 0 0.33 0.08399 mirMAP -0.16 0 NA
120 hsa-miR-141-3p GNE -5.02 0 0.89 0.00299 MirTarget -0.13 0 NA
121 hsa-miR-141-3p GNG4 -5.02 0 -0.22 0.74468 mirMAP -0.31 0 NA
122 hsa-miR-141-3p GNG7 -5.02 0 3.48 0 MirTarget; TargetScan; miRNATAP -0.3 0 NA
123 hsa-miR-141-3p GPC6 -5.02 0 2.71 0 TargetScan -0.64 0 NA
124 hsa-miR-141-3p GPD1 -5.02 0 1.45 0.00526 TargetScan -0.19 6.0E-5 NA
125 hsa-miR-141-3p GPM6B -5.02 0 2.39 0 TargetScan; miRNATAP -0.3 0 NA
126 hsa-miR-141-3p GPR174 -5.02 0 0.71 0.15454 TargetScan -0.28 0 NA
127 hsa-miR-141-3p GPR63 -5.02 0 0.92 0.01437 TargetScan -0.15 1.0E-5 NA
128 hsa-miR-141-3p GPRC5B -5.02 0 0.92 0.00843 mirMAP -0.17 0 NA
129 hsa-miR-141-3p GRAP2 -5.02 0 1.99 0 mirMAP -0.34 0 NA
130 hsa-miR-141-3p GRIK3 -5.02 0 4.42 0 mirMAP -0.34 0 NA
131 hsa-miR-141-3p GRIN3A -5.02 0 0.24 0.40319 TargetScan; miRNATAP -0.19 0 NA
132 hsa-miR-141-3p GSN -5.02 0 2.39 0 MirTarget -0.26 0 NA
133 hsa-miR-141-3p HAS2 -5.02 0 1.45 0.00631 MirTarget -0.37 0 NA
134 hsa-miR-141-3p HDAC4 -5.02 0 1.8 0 TargetScan; miRNATAP -0.22 0 NA
135 hsa-miR-141-3p HECW1 -5.02 0 -0.08 0.87699 TargetScan -0.23 0 NA
136 hsa-miR-141-3p HEYL -5.02 0 0.31 0.27592 mirMAP -0.21 0 NA
137 hsa-miR-141-3p HGF -5.02 0 2.97 0 MirTarget; TargetScan -0.68 0 NA
138 hsa-miR-141-3p HIPK3 -5.02 0 1.75 0 MirTarget; TargetScan -0.22 0 NA
139 hsa-miR-141-3p HIVEP3 -5.02 0 -0.03 0.92033 mirMAP -0.17 0 NA
140 hsa-miR-141-3p HLF -5.02 0 5.48 0 TargetScan -0.59 0 NA
141 hsa-miR-141-3p HOXA11 -5.02 0 0.78 0.02922 TargetScan; miRNATAP -0.12 0.00017 NA
142 hsa-miR-141-3p HS3ST3B1 -5.02 0 0.64 0.18337 mirMAP -0.38 0 NA
143 hsa-miR-141-3p HSPA13 -5.02 0 0.29 0.10635 TargetScan -0.13 0 NA
144 hsa-miR-141-3p IFFO2 -5.02 0 0.91 0.00201 MirTarget; TargetScan -0.1 0.00019 NA
145 hsa-miR-141-3p IGDCC4 -5.02 0 1.99 0 TargetScan; miRNATAP -0.35 0 NA
146 hsa-miR-141-3p IGF2BP2 -5.02 0 -0.95 0.14454 MirTarget; TargetScan; miRNATAP -0.31 0 NA
147 hsa-miR-141-3p IGSF6 -5.02 0 -0.29 0.48351 TargetScan -0.26 0 NA
148 hsa-miR-141-3p IGSF9B -5.02 0 3.7 0 TargetScan -0.38 0 NA
149 hsa-miR-141-3p IL18R1 -5.02 0 0.49 0.12464 MirTarget -0.13 1.0E-5 NA
150 hsa-miR-141-3p IL6R -5.02 0 1.87 0 MirTarget -0.24 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELL DEVELOPMENT 79 1426 3.752e-17 1.746e-13
2 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 43 513 1.33e-15 3.094e-12
3 REGULATION OF CELL DIFFERENTIATION 77 1492 4.933e-15 6.847e-12
4 NEUROGENESIS 74 1402 5.886e-15 6.847e-12
5 CELLULAR COMPONENT MORPHOGENESIS 54 900 3.268e-13 2.243e-10
6 CARDIOVASCULAR SYSTEM DEVELOPMENT 50 788 3.374e-13 2.243e-10
7 CIRCULATORY SYSTEM DEVELOPMENT 50 788 3.374e-13 2.243e-10
8 POSITIVE REGULATION OF CELL DIFFERENTIATION 51 823 4.72e-13 2.745e-10
9 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 77 1672 1.817e-12 9.394e-10
10 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 68 1395 3.698e-12 1.721e-09
11 VASCULATURE DEVELOPMENT 36 469 4.178e-12 1.767e-09
12 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 58 1142 3.696e-11 1.433e-08
13 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 62 1275 4.298e-11 1.538e-08
14 BLOOD VESSEL MORPHOGENESIS 30 364 4.878e-11 1.621e-08
15 TISSUE DEVELOPMENT 69 1518 5.849e-11 1.814e-08
16 POSITIVE REGULATION OF CELL DEVELOPMENT 34 472 9.478e-11 2.756e-08
17 POSITIVE REGULATION OF NEURON DIFFERENTIATION 27 306 1.007e-10 2.758e-08
18 REGULATION OF NEURON DIFFERENTIATION 37 554 1.182e-10 3.055e-08
19 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 53 1021 1.309e-10 3.205e-08
20 REGULATION OF CELL PROJECTION ORGANIZATION 37 558 1.448e-10 3.37e-08
21 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 29 368 2.996e-10 6.504e-08
22 REGULATION OF CELLULAR COMPONENT MOVEMENT 44 771 3.075e-10 6.504e-08
23 REGULATION OF CELL DEVELOPMENT 46 836 3.855e-10 7.798e-08
24 NEURON PROJECTION MORPHOGENESIS 30 402 5.442e-10 1.055e-07
25 REGULATION OF NEURON PROJECTION DEVELOPMENT 30 408 7.744e-10 1.441e-07
26 LOCOMOTION 54 1114 1.029e-09 1.841e-07
27 NEURON PROJECTION DEVELOPMENT 35 545 1.092e-09 1.882e-07
28 REGULATION OF CELL MORPHOGENESIS 35 552 1.527e-09 2.537e-07
29 NEURON DIFFERENTIATION 46 874 1.598e-09 2.563e-07
30 POSITIVE REGULATION OF GENE EXPRESSION 71 1733 2.771e-09 4.298e-07
31 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 48 957 3.269e-09 4.906e-07
32 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 41 750 4.517e-09 6.369e-07
33 CENTRAL NERVOUS SYSTEM DEVELOPMENT 45 872 4.476e-09 6.369e-07
34 NEURON PROJECTION GUIDANCE 20 205 5.074e-09 6.745e-07
35 ANGIOGENESIS 24 293 4.979e-09 6.745e-07
36 NEURON DEVELOPMENT 38 687 1.26e-08 1.628e-06
37 CELL PROJECTION ORGANIZATION 44 902 3.528e-08 4.32e-06
38 BIOLOGICAL ADHESION 48 1032 3.494e-08 4.32e-06
39 POSITIVE REGULATION OF CELL PROLIFERATION 41 814 4.488e-08 5.355e-06
40 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 28 437 5.658e-08 6.582e-06
41 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 24 337 7.341e-08 8.332e-06
42 REGULATION OF EXTENT OF CELL GROWTH 13 101 9.978e-08 1.105e-05
43 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 36 689 1.285e-07 1.391e-05
44 MUSCLE TISSUE DEVELOPMENT 21 275 1.521e-07 1.587e-05
45 CELL PART MORPHOGENESIS 34 633 1.535e-07 1.587e-05
46 MUSCLE STRUCTURE DEVELOPMENT 27 432 1.621e-07 1.639e-05
47 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 22 303 1.853e-07 1.835e-05
48 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 19 232 2.031e-07 1.969e-05
49 HEART DEVELOPMENT 28 466 2.14e-07 2.032e-05
50 STEM CELL DIFFERENTIATION 17 190 2.549e-07 2.372e-05
51 TAXIS 27 464 6.628e-07 6.047e-05
52 HEAD DEVELOPMENT 35 709 7.337e-07 6.565e-05
53 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 15 162 8.376e-07 7.353e-05
54 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 35 724 1.185e-06 0.0001021
55 EMBRYONIC MORPHOGENESIS 29 539 1.255e-06 0.0001062
56 MESENCHYME DEVELOPMENT 16 190 1.293e-06 0.0001074
57 CONNECTIVE TISSUE DEVELOPMENT 16 194 1.702e-06 0.0001385
58 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 43 1004 1.726e-06 0.0001385
59 SENSORY ORGAN DEVELOPMENT 27 493 2.11e-06 0.0001664
60 GROWTH 24 410 2.522e-06 0.0001945
61 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 27 498 2.55e-06 0.0001945
62 MESENCHYMAL CELL DIFFERENTIATION 13 134 2.683e-06 0.0002014
63 MEMBRANE DEPOLARIZATION 9 61 2.983e-06 0.0002169
64 REGULATION OF CHONDROCYTE DIFFERENTIATION 8 46 2.974e-06 0.0002169
65 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 64 1805 3.246e-06 0.0002323
66 REGULATION OF CELL ADHESION 31 629 3.341e-06 0.0002356
67 REGULATION OF PHOSPHORUS METABOLIC PROCESS 59 1618 3.533e-06 0.0002453
68 POSITIVE REGULATION OF LOCOMOTION 24 420 3.816e-06 0.0002611
69 REGULATION OF CARTILAGE DEVELOPMENT 9 63 3.931e-06 0.0002651
70 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 63 1784 4.474e-06 0.0002974
71 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 5 14 5.127e-06 0.000336
72 REGULATION OF DEVELOPMENTAL GROWTH 19 289 5.498e-06 0.0003553
73 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 8 50 5.711e-06 0.000364
74 MULTICELLULAR ORGANISMAL SIGNALING 12 123 6.124e-06 0.0003851
75 REGULATION OF AXONOGENESIS 14 168 6.709e-06 0.0004163
76 RESPONSE TO WOUNDING 28 563 8.512e-06 0.000515
77 EMBRYO DEVELOPMENT 38 894 8.523e-06 0.000515
78 REGULATION OF CELL SIZE 14 172 8.801e-06 0.0005183
79 EYE DEVELOPMENT 20 326 8.767e-06 0.0005183
80 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 7 39 1.007e-05 0.0005859
81 NEURON MIGRATION 11 110 1.178e-05 0.0006764
82 DEVELOPMENTAL GROWTH 20 333 1.197e-05 0.0006792
83 ORGAN MORPHOGENESIS 36 841 1.278e-05 0.0007164
84 REGULATION OF CELLULAR COMPONENT SIZE 20 337 1.424e-05 0.0007888
85 SKELETAL SYSTEM DEVELOPMENT 24 455 1.458e-05 0.000798
86 ACTIN FILAMENT BASED MOVEMENT 10 93 1.548e-05 0.0008378
87 REGULATION OF ACTIN FILAMENT BASED PROCESS 19 312 1.628e-05 0.0008709
88 REGULATION OF MEMBRANE POTENTIAL 20 343 1.838e-05 0.0009687
89 STEM CELL DIVISION 6 29 1.874e-05 0.0009687
90 CARDIAC MUSCLE CELL CONTRACTION 6 29 1.874e-05 0.0009687
91 VASCULOGENESIS 8 59 2.02e-05 0.001033
92 CARDIOCYTE DIFFERENTIATION 10 96 2.051e-05 0.001037
93 CARDIAC MUSCLE TISSUE DEVELOPMENT 12 140 2.296e-05 0.001149
94 NEGATIVE REGULATION OF CELL COMMUNICATION 45 1192 2.493e-05 0.001234
95 CELL MOTILITY 35 835 2.621e-05 0.00127
96 LOCALIZATION OF CELL 35 835 2.621e-05 0.00127
97 REGULATION OF EPITHELIAL CELL MIGRATION 13 166 2.767e-05 0.001314
98 POSITIVE REGULATION OF CHONDROCYTE DIFFERENTIATION 5 19 2.744e-05 0.001314
99 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 49 1360 3.544e-05 0.001665
100 ACTIN FILAMENT BASED PROCESS 23 450 3.59e-05 0.00167
101 MUSCLE ORGAN DEVELOPMENT 17 277 4.101e-05 0.001871
102 EMBRYONIC DIGESTIVE TRACT DEVELOPMENT 6 33 4.086e-05 0.001871
103 INTRACELLULAR SIGNAL TRANSDUCTION 54 1572 4.997e-05 0.002257
104 REGULATION OF CELL PROLIFERATION 52 1496 5.155e-05 0.002306
105 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 22 437 6.617e-05 0.002932
106 CARDIAC MUSCLE CELL ACTION POTENTIAL 6 37 8.022e-05 0.003521
107 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 25 541 8.516e-05 0.003623
108 TUBE MORPHOGENESIS 18 323 8.565e-05 0.003623
109 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 25 541 8.516e-05 0.003623
110 REGULATION OF STEM CELL DIFFERENTIATION 10 113 8.384e-05 0.003623
111 HINDBRAIN DEVELOPMENT 11 137 9.088e-05 0.003692
112 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 60 1848 9.126e-05 0.003692
113 HEART MORPHOGENESIS 14 212 8.946e-05 0.003692
114 SKELETAL MUSCLE ORGAN DEVELOPMENT 11 137 9.088e-05 0.003692
115 NEGATIVE REGULATION OF CELL DIFFERENTIATION 27 609 8.929e-05 0.003692
116 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 39 1036 9.471e-05 0.003703
117 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 39 1036 9.471e-05 0.003703
118 SEMAPHORIN PLEXIN SIGNALING PATHWAY INVOLVED IN NEURON PROJECTION GUIDANCE 4 13 9.394e-05 0.003703
119 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 5 24 9.246e-05 0.003703
120 FOREBRAIN DEVELOPMENT 19 357 0.0001007 0.003903
121 ACTION POTENTIAL 9 94 0.0001031 0.003937
122 REGULATION OF ORGAN MORPHOGENESIS 15 242 0.0001032 0.003937
123 CARDIAC MUSCLE CELL DIFFERENTIATION 8 74 0.000106 0.004012
124 EPITHELIAL TO MESENCHYMAL TRANSITION 7 56 0.0001138 0.004168
125 MEMBRANE ASSEMBLY 5 25 0.0001137 0.004168
126 NEGATIVE REGULATION OF PHOSPHORYLATION 21 422 0.0001136 0.004168
127 OUTFLOW TRACT MORPHOGENESIS 7 56 0.0001138 0.004168
128 TUBE DEVELOPMENT 25 552 0.0001168 0.004245
129 VASCULAR ENDOTHELIAL GROWTH FACTOR SIGNALING PATHWAY 4 14 0.0001295 0.00467
130 PROTEIN PHOSPHORYLATION 36 944 0.0001378 0.00493
131 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 32 801 0.0001423 0.005056
132 SYNAPSE ORGANIZATION 11 145 0.0001509 0.005319
133 METENCEPHALON DEVELOPMENT 9 100 0.0001661 0.005811
134 CARTILAGE DEVELOPMENT 11 147 0.0001703 0.005913
135 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 30 740 0.0001788 0.006162
136 REGULATION OF ANATOMICAL STRUCTURE SIZE 22 472 0.0001996 0.006828
137 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 9 103 0.000208 0.007066
138 CELL CELL ADHESION 26 608 0.0002127 0.007171
139 CARDIAC CONDUCTION 8 82 0.0002186 0.007318
140 RETINA VASCULATURE DEVELOPMENT IN CAMERA TYPE EYE 4 16 0.0002281 0.007582
141 POSITIVE REGULATION OF CARTILAGE DEVELOPMENT 5 29 0.0002381 0.007858
142 REGULATION OF FAT CELL DIFFERENTIATION 9 106 0.0002584 0.008469
143 CARDIAC SEPTUM DEVELOPMENT 8 85 0.0002804 0.00896
144 MEMBRANE BIOGENESIS 5 30 0.0002812 0.00896
145 AMINOGLYCAN BIOSYNTHETIC PROCESS 9 107 0.0002773 0.00896
146 REGULATION OF HEART RATE BY CARDIAC CONDUCTION 5 30 0.0002812 0.00896
147 BONE DEVELOPMENT 11 156 0.000286 0.009001
148 MUSCLE CELL DIFFERENTIATION 14 237 0.0002863 0.009001
149 POSITIVE REGULATION OF RESPONSE TO STIMULUS 60 1929 0.00029 0.009056
150 REGULATION OF CELL GROWTH 19 391 0.0003212 0.009965
NumGOOverlapSizeP ValueAdj. P Value
1 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 36 629 1.304e-08 1.211e-05
2 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 51 1199 2.103e-07 9.77e-05
3 CYTOSKELETAL PROTEIN BINDING 38 819 1.099e-06 0.0003404
4 REGULATORY REGION NUCLEIC ACID BINDING 37 818 2.771e-06 0.0006437
5 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 20 328 9.592e-06 0.001485
6 SEQUENCE SPECIFIC DNA BINDING 42 1037 9.121e-06 0.001485
7 ACTIN BINDING 21 393 4.137e-05 0.005196
8 SEMAPHORIN RECEPTOR ACTIVITY 4 11 4.474e-05 0.005196
9 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 18 315 6.218e-05 0.006419
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 61 1151 1.778e-12 1.038e-09
2 CELL PROJECTION 75 1786 2.926e-10 8.544e-08
3 SYNAPSE 42 754 1.657e-09 3.227e-07
4 NEURON PART 55 1265 3.172e-08 4.631e-06
5 NEURON PROJECTION 43 942 3.201e-07 3.739e-05
6 CELL LEADING EDGE 22 350 2.104e-06 0.0002048
7 CYTOSKELETON 66 1967 1.37e-05 0.001143
8 ACTIN CYTOSKELETON 23 444 2.915e-05 0.001741
9 CELL CELL JUNCTION 21 383 2.842e-05 0.001741
10 CELL PROJECTION PART 38 946 2.98e-05 0.001741
11 SITE OF POLARIZED GROWTH 12 149 4.261e-05 0.002178
12 SEMAPHORIN RECEPTOR COMPLEX 4 11 4.474e-05 0.002178
13 CELL SUBSTRATE JUNCTION 21 398 4.964e-05 0.00223
14 MICROTUBULE END 5 22 5.918e-05 0.002469
15 VOLTAGE GATED SODIUM CHANNEL COMPLEX 4 14 0.0001295 0.004726
16 ANCHORING JUNCTION 23 489 0.0001257 0.004726
17 LAMELLIPODIUM 12 172 0.0001691 0.005809
18 SODIUM CHANNEL COMPLEX 4 17 0.0002937 0.009027
19 MICROTUBULE PLUS END 4 17 0.0002937 0.009027

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04514_Cell_adhesion_molecules_.CAMs. 12 136 1.715e-05 0.003087
2 hsa04014_Ras_signaling_pathway 13 236 0.0008978 0.04564
3 hsa04722_Neurotrophin_signaling_pathway 9 127 0.0009706 0.04564
4 hsa04390_Hippo_signaling_pathway 10 154 0.001014 0.04564
5 hsa04010_MAPK_signaling_pathway 13 268 0.00278 0.1001
6 hsa04310_Wnt_signaling_pathway 8 151 0.01054 0.2733
7 hsa04151_PI3K_AKT_signaling_pathway 14 351 0.01063 0.2733
8 hsa04360_Axon_guidance 7 130 0.01499 0.3372
9 hsa04630_Jak.STAT_signaling_pathway 7 155 0.03494 0.6987
10 hsa04380_Osteoclast_differentiation 6 128 0.04212 0.7582
11 hsa04962_Vasopressin.regulated_water_reabsorption 3 44 0.0562 0.9196
12 hsa04810_Regulation_of_actin_cytoskeleton 8 214 0.06355 0.9422
13 hsa04710_Circadian_rhythm_._mammal 2 23 0.0753 0.9422
14 hsa00760_Nicotinate_and_nicotinamide_metabolism 2 24 0.08111 0.9422
15 hsa04350_TGF.beta_signaling_pathway 4 85 0.08829 0.9422
16 hsa04512_ECM.receptor_interaction 4 85 0.08829 0.9422
17 hsa00601_Glycosphingolipid_biosynthesis_._lacto_and_neolacto_series 2 26 0.09311 0.9422
18 hsa04012_ErbB_signaling_pathway 4 87 0.09422 0.9422
19 hsa04510_Focal_adhesion 7 200 0.1034 0.9796
20 hsa04110_Cell_cycle 5 128 0.1108 0.9973
21 hsa04912_GnRH_signaling_pathway 4 101 0.1406 1
22 hsa04916_Melanogenesis 4 101 0.1406 1
23 hsa04130_SNARE_interactions_in_vesicular_transport 2 36 0.1591 1
24 hsa04720_Long.term_potentiation 3 70 0.1614 1
25 hsa04971_Gastric_acid_secretion 3 74 0.1809 1
26 hsa04640_Hematopoietic_cell_lineage 3 88 0.2531 1
27 hsa04540_Gap_junction 3 90 0.2638 1
28 hsa04530_Tight_junction 4 133 0.2702 1
29 hsa04020_Calcium_signaling_pathway 5 177 0.274 1
30 hsa04666_Fc_gamma_R.mediated_phagocytosis 3 95 0.2907 1
31 hsa04340_Hedgehog_signaling_pathway 2 56 0.3046 1
32 hsa04062_Chemokine_signaling_pathway 5 189 0.3202 1
33 hsa04660_T_cell_receptor_signaling_pathway 3 108 0.3612 1
34 hsa04920_Adipocytokine_signaling_pathway 2 68 0.3909 1
35 hsa04115_p53_signaling_pathway 2 69 0.3979 1
36 hsa04270_Vascular_smooth_muscle_contraction 3 116 0.4041 1
37 hsa04730_Long.term_depression 2 70 0.4049 1
38 hsa04520_Adherens_junction 2 73 0.4255 1
39 hsa04664_Fc_epsilon_RI_signaling_pathway 2 79 0.4656 1
40 hsa00564_Glycerophospholipid_metabolism 2 80 0.4722 1
41 hsa04974_Protein_digestion_and_absorption 2 81 0.4786 1
42 hsa04914_Progesterone.mediated_oocyte_maturation 2 87 0.5164 1
43 hsa04910_Insulin_signaling_pathway 3 138 0.5167 1
44 hsa04210_Apoptosis 2 89 0.5286 1
45 hsa04970_Salivary_secretion 2 89 0.5286 1
46 hsa04142_Lysosome 2 121 0.6946 1
47 hsa04145_Phagosome 2 156 0.8178 1
48 hsa04144_Endocytosis 2 203 0.9131 1
49 hsa04740_Olfactory_transduction 2 388 0.9964 1

Quest ID: 3bd37a2a78a9967906606817b21d8edf