This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are
presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.
"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.
Num | microRNA | Gene | miRNA log2FC | miRNA pvalue | Gene log2FC | Gene pvalue | Interaction | Correlation beta | Correlation P-value | PMID | Reported in cancer studies |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | hsa-miR-16-5p | AADAT | 0.47 | 0.02635 | -0.43 | 0.07498 | miRNAWalker2 validate | -0.28 | 6.0E-5 | NA | |
2 | hsa-miR-16-5p | ABCB5 | 0.47 | 0.02635 | -0.96 | 0.04077 | MirTarget | -1.06 | 0 | NA | |
3 | hsa-miR-16-5p | ABCC1 | 0.47 | 0.02635 | 0.34 | 0.00384 | miRNAWalker2 validate | -0.1 | 0.0029 | NA | |
4 | hsa-miR-16-5p | ABL1 | 0.47 | 0.02635 | -0.21 | 0.07804 | mirMAP | -0.25 | 0 | NA | |
5 | hsa-miR-16-5p | ABL2 | 0.47 | 0.02635 | 0.82 | 0 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.13 | 3.0E-5 | NA | |
6 | hsa-miR-16-5p | ABTB2 | 0.47 | 0.02635 | 0.16 | 0.33586 | MirTarget | -0.13 | 0.00519 | NA | |
7 | hsa-miR-16-5p | ACSBG1 | 0.47 | 0.02635 | -0.89 | 4.0E-5 | MirTarget | -0.57 | 0 | NA | |
8 | hsa-miR-16-5p | ACTB | 0.47 | 0.02635 | -0.25 | 0.01736 | miRNAWalker2 validate | -0.16 | 0 | NA | |
9 | hsa-miR-16-5p | ACTN1 | 0.47 | 0.02635 | 0.14 | 0.44606 | miRNAWalker2 validate | -0.5 | 0 | NA | |
10 | hsa-miR-16-5p | ACVR2A | 0.47 | 0.02635 | -0.41 | 0.00039 | miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP | -0.2 | 0 | NA | |
11 | hsa-miR-16-5p | ACVR2B | 0.47 | 0.02635 | 0.48 | 0.00365 | miRNATAP | -0.12 | 0.01367 | NA | |
12 | hsa-miR-16-5p | ADAMTS18 | 0.47 | 0.02635 | 3.26 | 0 | miRNATAP | -0.24 | 0.03133 | NA | |
13 | hsa-miR-16-5p | ADAMTS3 | 0.47 | 0.02635 | 0.38 | 0.04723 | miRNATAP | -0.31 | 0 | NA | |
14 | hsa-miR-16-5p | ADAMTS5 | 0.47 | 0.02635 | 0.19 | 0.27716 | miRNATAP | -0.28 | 0 | NA | |
15 | hsa-miR-16-5p | ADAMTSL3 | 0.47 | 0.02635 | -1.56 | 0 | MirTarget | -0.86 | 0 | NA | |
16 | hsa-miR-16-5p | ADCY2 | 0.47 | 0.02635 | -1.53 | 4.0E-5 | mirMAP | -1.03 | 0 | NA | |
17 | hsa-miR-16-5p | ADCY5 | 0.47 | 0.02635 | -1.84 | 1.0E-5 | MirTarget; miRNATAP | -1.19 | 0 | NA | |
18 | hsa-miR-16-5p | ADRB2 | 0.47 | 0.02635 | -2.78 | 0 | MirTarget | -0.45 | 0 | NA | |
19 | hsa-miR-16-5p | AFF4 | 0.47 | 0.02635 | -0.27 | 0.01565 | MirTarget; miRNATAP | -0.21 | 0 | NA | |
20 | hsa-miR-16-5p | AGPAT4 | 0.47 | 0.02635 | 0.09 | 0.61321 | mirMAP | -0.4 | 0 | NA | |
21 | hsa-miR-16-5p | AHNAK2 | 0.47 | 0.02635 | -0.59 | 0.13882 | miRNAWalker2 validate | -1.14 | 0 | NA | |
22 | hsa-miR-16-5p | AK4 | 0.47 | 0.02635 | -1.12 | 0.00017 | MirTarget; miRNATAP | -0.47 | 0 | NA | |
23 | hsa-miR-16-5p | AKAP11 | 0.47 | 0.02635 | 0.2 | 0.09825 | MirTarget; miRNATAP | -0.19 | 0 | NA | |
24 | hsa-miR-16-5p | AKT3 | 0.47 | 0.02635 | -0.27 | 0.18865 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.57 | 0 | NA | |
25 | hsa-miR-16-5p | AMOTL1 | 0.47 | 0.02635 | -0.49 | 0.0546 | MirTarget; miRNATAP | -0.66 | 0 | NA | |
26 | hsa-miR-16-5p | ANAPC16 | 0.47 | 0.02635 | -0.56 | 0 | miRNAWalker2 validate | -0.13 | 1.0E-5 | NA | |
27 | hsa-miR-16-5p | ANK2 | 0.47 | 0.02635 | -1.6 | 1.0E-5 | MirTarget; miRNATAP | -1.03 | 0 | NA | |
28 | hsa-miR-16-5p | ANKRD29 | 0.47 | 0.02635 | -1.35 | 1.0E-5 | MirTarget | -0.51 | 0 | NA | |
29 | hsa-miR-16-5p | ANKS1A | 0.47 | 0.02635 | -0.13 | 0.22949 | MirTarget | -0.26 | 0 | NA | |
30 | hsa-miR-16-5p | ANO3 | 0.47 | 0.02635 | -0.68 | 0.15551 | MirTarget; miRNATAP | -0.28 | 0.04553 | NA | |
31 | hsa-miR-16-5p | AR | 0.47 | 0.02635 | -1.55 | 0 | mirMAP; miRNATAP | -0.99 | 0 | NA | |
32 | hsa-miR-16-5p | ARHGAP20 | 0.47 | 0.02635 | -1.38 | 0 | MirTarget; miRNATAP | -0.75 | 0 | NA | |
33 | hsa-miR-16-5p | ARHGAP5 | 0.47 | 0.02635 | -0.12 | 0.26304 | MirTarget; miRNATAP | -0.21 | 0 | NA | |
34 | hsa-miR-16-5p | ARHGEF12 | 0.47 | 0.02635 | 0.09 | 0.35693 | MirTarget | -0.17 | 0 | NA | |
35 | hsa-miR-16-5p | ARHGEF9 | 0.47 | 0.02635 | -0.63 | 0 | miRNATAP | -0.23 | 0 | NA | |
36 | hsa-miR-16-5p | ARIH1 | 0.47 | 0.02635 | 0.02 | 0.79347 | MirTarget | -0.12 | 0 | NA | |
37 | hsa-miR-16-5p | ARL10 | 0.47 | 0.02635 | -0.28 | 0.19832 | miRNAWalker2 validate | -0.49 | 0 | NA | |
38 | hsa-miR-16-5p | ARL3 | 0.47 | 0.02635 | -0.52 | 0 | miRNAWalker2 validate; MirTarget | -0.12 | 7.0E-5 | NA | |
39 | hsa-miR-16-5p | ARL8B | 0.47 | 0.02635 | -0.21 | 0.01117 | MirTarget; miRNATAP | -0.16 | 0 | NA | |
40 | hsa-miR-16-5p | ARMCX2 | 0.47 | 0.02635 | -0.77 | 0.00112 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.53 | 0 | NA | |
41 | hsa-miR-16-5p | ARNT2 | 0.47 | 0.02635 | -0.33 | 0.25851 | mirMAP | -0.26 | 0.00249 | NA | |
42 | hsa-miR-16-5p | ARVCF | 0.47 | 0.02635 | 0.32 | 0.05547 | mirMAP | -0.27 | 0 | NA | |
43 | hsa-miR-16-5p | ASB1 | 0.47 | 0.02635 | -0.28 | 0.00868 | MirTarget | -0.21 | 0 | NA | |
44 | hsa-miR-16-5p | ASH1L | 0.47 | 0.02635 | 0.11 | 0.30048 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.2 | 0 | NA | |
45 | hsa-miR-16-5p | ASTN1 | 0.47 | 0.02635 | -2.39 | 2.0E-5 | MirTarget | -1.23 | 0 | NA | |
46 | hsa-miR-16-5p | ATF7 | 0.47 | 0.02635 | 0.07 | 0.43806 | miRNAWalker2 validate | -0.22 | 0 | NA | |
47 | hsa-miR-16-5p | ATG14 | 0.47 | 0.02635 | 0 | 0.96836 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.27 | 0 | NA | |
48 | hsa-miR-16-5p | ATL2 | 0.47 | 0.02635 | -0.38 | 0.00058 | miRNAWalker2 validate | -0.25 | 0 | NA | |
49 | hsa-miR-16-5p | ATP2B2 | 0.47 | 0.02635 | -1.89 | 0 | MirTarget; miRNATAP | -0.94 | 0 | NA | |
50 | hsa-miR-16-5p | ATP7A | 0.47 | 0.02635 | -0.24 | 0.02606 | MirTarget | -0.12 | 5.0E-5 | NA | |
51 | hsa-miR-16-5p | ATP8A2 | 0.47 | 0.02635 | -1.33 | 1.0E-5 | miRNAWalker2 validate | -0.31 | 0.0004 | NA | |
52 | hsa-miR-16-5p | ATXN1L | 0.47 | 0.02635 | -0.07 | 0.43241 | miRNATAP | -0.14 | 0 | NA | |
53 | hsa-miR-16-5p | ATXN2 | 0.47 | 0.02635 | 0.27 | 0.00072 | MirTarget; miRNATAP | -0.14 | 0 | NA | |
54 | hsa-miR-16-5p | ATXN7L1 | 0.47 | 0.02635 | 0.06 | 0.53653 | miRNATAP | -0.15 | 0 | NA | |
55 | hsa-miR-16-5p | BACE1 | 0.47 | 0.02635 | -0.1 | 0.49755 | miRNATAP | -0.36 | 0 | NA | |
56 | hsa-miR-16-5p | BACH2 | 0.47 | 0.02635 | -0.15 | 0.55909 | MirTarget; miRNATAP | -0.34 | 1.0E-5 | NA | |
57 | hsa-miR-16-5p | BCAP29 | 0.47 | 0.02635 | -0.09 | 0.29187 | MirTarget | -0.17 | 0 | NA | |
58 | hsa-miR-16-5p | BCL2 | 0.47 | 0.02635 | -0.9 | 0 | miRNAWalker2 validate; miRTarBase | -0.31 | 0 | 18449891; 21336967; 24447552; 25435430; 24598659; 18931683; 22966344; 25623762 | miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells |
59 | hsa-miR-16-5p | BHLHE41 | 0.47 | 0.02635 | 0.35 | 0.12753 | miRNATAP | -0.34 | 0 | NA | |
60 | hsa-miR-16-5p | BMX | 0.47 | 0.02635 | -1.36 | 0 | MirTarget; miRNATAP | -0.41 | 0 | NA | |
61 | hsa-miR-16-5p | BNC2 | 0.47 | 0.02635 | -0.49 | 0.09988 | miRNAWalker2 validate | -0.9 | 0 | NA | |
62 | hsa-miR-16-5p | BRD3 | 0.47 | 0.02635 | 0.37 | 0.00013 | mirMAP | -0.15 | 0 | NA | |
63 | hsa-miR-16-5p | BRSK2 | 0.47 | 0.02635 | 0.55 | 0.14019 | mirMAP | -0.45 | 3.0E-5 | NA | |
64 | hsa-miR-16-5p | BTBD19 | 0.47 | 0.02635 | 0.96 | 0 | mirMAP | -0.37 | 0 | NA | |
65 | hsa-miR-16-5p | BTG2 | 0.47 | 0.02635 | -1.76 | 0 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.27 | 3.0E-5 | NA | |
66 | hsa-miR-16-5p | BTRC | 0.47 | 0.02635 | -0.03 | 0.74173 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.13 | 0 | NA | |
67 | hsa-miR-16-5p | BVES | 0.47 | 0.02635 | -1.51 | 1.0E-5 | MirTarget | -1.02 | 0 | NA | |
68 | hsa-miR-16-5p | C15orf52 | 0.47 | 0.02635 | -0.77 | 0.00649 | mirMAP | -0.85 | 0 | NA | |
69 | hsa-miR-16-5p | C16orf52 | 0.47 | 0.02635 | -0.07 | 0.3851 | miRNATAP | -0.18 | 0 | NA | |
70 | hsa-miR-16-5p | C1orf21 | 0.47 | 0.02635 | -0.73 | 9.0E-5 | mirMAP; miRNATAP | -0.38 | 0 | NA | |
71 | hsa-miR-16-5p | CACNA1E | 0.47 | 0.02635 | 1.75 | 0 | MirTarget | -0.23 | 0.03849 | NA | |
72 | hsa-miR-16-5p | CACNA2D1 | 0.47 | 0.02635 | -0.85 | 0.00675 | miRNAWalker2 validate | -0.8 | 0 | NA | |
73 | hsa-miR-16-5p | CACNB2 | 0.47 | 0.02635 | -1.06 | 0.00045 | miRNAWalker2 validate | -0.95 | 0 | NA | |
74 | hsa-miR-16-5p | CACNB4 | 0.47 | 0.02635 | -1.06 | 0.0002 | miRNATAP | -0.57 | 0 | NA | |
75 | hsa-miR-16-5p | CADM1 | 0.47 | 0.02635 | -0.9 | 0.00084 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.32 | 5.0E-5 | NA | |
76 | hsa-miR-16-5p | CALM1 | 0.47 | 0.02635 | -0.78 | 0 | miRNATAP | -0.17 | 0 | NA | |
77 | hsa-miR-16-5p | CALU | 0.47 | 0.02635 | 0.67 | 0 | miRNAWalker2 validate; MirTarget | -0.11 | 0.0011 | NA | |
78 | hsa-miR-16-5p | CAMK2G | 0.47 | 0.02635 | -0.53 | 0.00041 | miRNAWalker2 validate | -0.44 | 0 | NA | |
79 | hsa-miR-16-5p | CAMKV | 0.47 | 0.02635 | 0.37 | 0.43837 | miRNAWalker2 validate; miRNATAP | -0.29 | 0.03624 | NA | |
80 | hsa-miR-16-5p | CAMSAP1 | 0.47 | 0.02635 | 0.24 | 0.03991 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.1 | 0.00344 | NA | |
81 | hsa-miR-16-5p | CAMSAP2 | 0.47 | 0.02635 | 0.42 | 0.00053 | miRNATAP | -0.29 | 0 | NA | |
82 | hsa-miR-16-5p | CAPN6 | 0.47 | 0.02635 | -1.29 | 0.02537 | miRNATAP | -0.64 | 0.00013 | NA | |
83 | hsa-miR-16-5p | CAPZA2 | 0.47 | 0.02635 | -0.19 | 0.08777 | miRNAWalker2 validate; MirTarget | -0.16 | 0 | NA | |
84 | hsa-miR-16-5p | CASZ1 | 0.47 | 0.02635 | -0.74 | 0 | MirTarget | -0.17 | 8.0E-5 | NA | |
85 | hsa-miR-16-5p | CBFA2T3 | 0.47 | 0.02635 | -1.22 | 1.0E-5 | MirTarget; miRNATAP | -0.26 | 0.00132 | NA | |
86 | hsa-miR-16-5p | CBL | 0.47 | 0.02635 | 0.29 | 0.01267 | mirMAP | -0.13 | 8.0E-5 | NA | |
87 | hsa-miR-16-5p | CBX5 | 0.47 | 0.02635 | 0.16 | 0.24446 | miRNATAP | -0.11 | 0.00638 | NA | |
88 | hsa-miR-16-5p | CCDC144A | 0.47 | 0.02635 | -0.22 | 0.66837 | mirMAP | -0.48 | 0.00167 | NA | |
89 | hsa-miR-16-5p | CCDC149 | 0.47 | 0.02635 | -0.52 | 0.00236 | MirTarget | -0.25 | 0 | NA | |
90 | hsa-miR-16-5p | CCDC6 | 0.47 | 0.02635 | 0.27 | 0.02555 | MirTarget; miRNATAP | -0.16 | 0 | NA | |
91 | hsa-miR-16-5p | CCND2 | 0.47 | 0.02635 | -0.27 | 0.3112 | miRNAWalker2 validate; miRNATAP | -0.52 | 0 | NA | |
92 | hsa-miR-16-5p | CCPG1 | 0.47 | 0.02635 | -0.21 | 0.04535 | miRNAWalker2 validate | -0.13 | 1.0E-5 | NA | |
93 | hsa-miR-16-5p | CD44 | 0.47 | 0.02635 | 0.22 | 0.30295 | miRNAWalker2 validate | -0.18 | 0.00451 | NA | |
94 | hsa-miR-16-5p | CDADC1 | 0.47 | 0.02635 | -0.18 | 0.09805 | miRNAWalker2 validate | -0.12 | 9.0E-5 | NA | |
95 | hsa-miR-16-5p | CDC37L1 | 0.47 | 0.02635 | -0.43 | 9.0E-5 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.15 | 0 | NA | |
96 | hsa-miR-16-5p | CDK17 | 0.47 | 0.02635 | 0.07 | 0.48708 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.23 | 0 | NA | |
97 | hsa-miR-16-5p | CDS2 | 0.47 | 0.02635 | -0.26 | 0.01248 | miRNAWalker2 validate; mirMAP; miRNATAP | -0.24 | 0 | NA | |
98 | hsa-miR-16-5p | CEP63 | 0.47 | 0.02635 | -0.1 | 0.21895 | miRNAWalker2 validate | -0.14 | 0 | NA | |
99 | hsa-miR-16-5p | CFL2 | 0.47 | 0.02635 | -1.3 | 0 | miRNAWalker2 validate | -0.83 | 0 | NA | |
100 | hsa-miR-16-5p | CHD3 | 0.47 | 0.02635 | -0 | 0.99669 | miRNAWalker2 validate | -0.16 | 4.0E-5 | NA | |
101 | hsa-miR-16-5p | CHD5 | 0.47 | 0.02635 | -0.92 | 0.01521 | miRNATAP | -0.94 | 0 | NA | |
102 | hsa-miR-16-5p | CHD9 | 0.47 | 0.02635 | -0.26 | 0.02092 | miRNATAP | -0.26 | 0 | NA | |
103 | hsa-miR-16-5p | CLASP1 | 0.47 | 0.02635 | 0.09 | 0.35045 | miRNAWalker2 validate | -0.2 | 0 | NA | |
104 | hsa-miR-16-5p | CLOCK | 0.47 | 0.02635 | -0.1 | 0.34735 | MirTarget | -0.13 | 2.0E-5 | NA | |
105 | hsa-miR-16-5p | CNKSR2 | 0.47 | 0.02635 | -1.85 | 0.00014 | miRNATAP | -1.33 | 0 | NA | |
106 | hsa-miR-16-5p | CNN1 | 0.47 | 0.02635 | -2.63 | 0 | miRNATAP | -1.53 | 0 | NA | |
107 | hsa-miR-16-5p | CNN3 | 0.47 | 0.02635 | -0.56 | 0.00032 | miRNAWalker2 validate | -0.27 | 0 | NA | |
108 | hsa-miR-16-5p | CNTNAP1 | 0.47 | 0.02635 | 0.36 | 0.13727 | MirTarget | -0.6 | 0 | NA | |
109 | hsa-miR-16-5p | COL12A1 | 0.47 | 0.02635 | 1.85 | 0 | MirTarget; miRNATAP | -0.32 | 1.0E-5 | NA | |
110 | hsa-miR-16-5p | COL24A1 | 0.47 | 0.02635 | 0.06 | 0.83086 | MirTarget; miRNATAP | -0.59 | 0 | NA | |
111 | hsa-miR-16-5p | COL4A1 | 0.47 | 0.02635 | 1.79 | 0 | miRNAWalker2 validate | -0.15 | 0.01216 | NA | |
112 | hsa-miR-16-5p | COL4A2 | 0.47 | 0.02635 | 1.02 | 0 | miRNAWalker2 validate | -0.28 | 0 | NA | |
113 | hsa-miR-16-5p | COL4A3BP | 0.47 | 0.02635 | -0.44 | 0 | MirTarget; miRNATAP | -0.16 | 0 | NA | |
114 | hsa-miR-16-5p | COL4A4 | 0.47 | 0.02635 | 0.2 | 0.56272 | mirMAP | -0.44 | 1.0E-5 | NA | |
115 | hsa-miR-16-5p | COLQ | 0.47 | 0.02635 | -0.03 | 0.88881 | MirTarget | -0.39 | 0 | NA | |
116 | hsa-miR-16-5p | COPS2 | 0.47 | 0.02635 | -0.18 | 0.04974 | MirTarget | -0.13 | 0 | NA | |
117 | hsa-miR-16-5p | CPEB2 | 0.47 | 0.02635 | -0.81 | 0 | miRNATAP | -0.29 | 0 | NA | |
118 | hsa-miR-16-5p | CPEB3 | 0.47 | 0.02635 | -0.73 | 0 | MirTarget; miRNATAP | -0.19 | 0 | NA | |
119 | hsa-miR-16-5p | CPNE8 | 0.47 | 0.02635 | 0.01 | 0.9743 | miRNAWalker2 validate | -0.38 | 0 | NA | |
120 | hsa-miR-16-5p | CREB3L2 | 0.47 | 0.02635 | -0.53 | 2.0E-5 | miRNAWalker2 validate | -0.18 | 0 | NA | |
121 | hsa-miR-16-5p | CREB5 | 0.47 | 0.02635 | 0.01 | 0.953 | miRNATAP | -0.43 | 0 | NA | |
122 | hsa-miR-16-5p | CREBL2 | 0.47 | 0.02635 | -0.29 | 0.00289 | miRNAWalker2 validate | -0.14 | 0 | NA | |
123 | hsa-miR-16-5p | CREBRF | 0.47 | 0.02635 | -0.37 | 0.00727 | MirTarget; miRNATAP | -0.41 | 0 | NA | |
124 | hsa-miR-16-5p | CRHBP | 0.47 | 0.02635 | -1.87 | 0 | miRNAWalker2 validate | -0.5 | 0 | NA | |
125 | hsa-miR-16-5p | CRIM1 | 0.47 | 0.02635 | 0.2 | 0.18944 | MirTarget; miRNATAP | -0.31 | 0 | NA | |
126 | hsa-miR-16-5p | CRTC3 | 0.47 | 0.02635 | 0.16 | 0.16786 | miRNATAP | -0.23 | 0 | NA | |
127 | hsa-miR-16-5p | CSDE1 | 0.47 | 0.02635 | -0.49 | 0 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.22 | 0 | NA | |
128 | hsa-miR-16-5p | CSGALNACT1 | 0.47 | 0.02635 | 0.02 | 0.92021 | miRNAWalker2 validate | -0.19 | 2.0E-5 | NA | |
129 | hsa-miR-16-5p | CSRNP1 | 0.47 | 0.02635 | -1.45 | 0 | MirTarget | -0.17 | 0.00117 | NA | |
130 | hsa-miR-16-5p | CSRNP2 | 0.47 | 0.02635 | 0.24 | 0.00293 | miRNATAP | -0.11 | 0 | NA | |
131 | hsa-miR-16-5p | CTDSPL | 0.47 | 0.02635 | 0.08 | 0.45121 | miRNATAP | -0.18 | 0 | NA | |
132 | hsa-miR-16-5p | CYS1 | 0.47 | 0.02635 | -1.28 | 0.00036 | mirMAP | -0.94 | 0 | NA | |
133 | hsa-miR-16-5p | DCAF5 | 0.47 | 0.02635 | -0.43 | 0 | MirTarget; miRNATAP | -0.14 | 0 | NA | |
134 | hsa-miR-16-5p | DCLK1 | 0.47 | 0.02635 | -1.32 | 0.00014 | miRNATAP | -0.84 | 0 | NA | |
135 | hsa-miR-16-5p | DCUN1D4 | 0.47 | 0.02635 | -0.26 | 0.02159 | MirTarget; miRNATAP | -0.23 | 0 | NA | |
136 | hsa-miR-16-5p | DCX | 0.47 | 0.02635 | -0.84 | 0.10669 | mirMAP | -0.99 | 0 | NA | |
137 | hsa-miR-16-5p | DDHD2 | 0.47 | 0.02635 | -0.15 | 0.19384 | miRNAWalker2 validate | -0.21 | 0 | NA | |
138 | hsa-miR-16-5p | DDX3Y | 0.47 | 0.02635 | -1.08 | 0.26927 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.67 | 0.01858 | NA | |
139 | hsa-miR-16-5p | DDX6 | 0.47 | 0.02635 | 0.09 | 0.36428 | miRNAWalker2 validate | -0.21 | 0 | NA | |
140 | hsa-miR-16-5p | DENND4A | 0.47 | 0.02635 | 0.06 | 0.54641 | MirTarget | -0.15 | 0 | NA | |
141 | hsa-miR-16-5p | DEPTOR | 0.47 | 0.02635 | -0.64 | 0.00063 | MirTarget | -0.12 | 0.03198 | NA | |
142 | hsa-miR-16-5p | DICER1 | 0.47 | 0.02635 | 0.04 | 0.674 | miRNAWalker2 validate | -0.11 | 0.00017 | NA | |
143 | hsa-miR-16-5p | DIXDC1 | 0.47 | 0.02635 | -1.16 | 0 | miRNAWalker2 validate; MirTarget | -0.8 | 0 | NA | |
144 | hsa-miR-16-5p | DLC1 | 0.47 | 0.02635 | -0.38 | 0.05038 | miRNAWalker2 validate | -0.47 | 0 | NA | |
145 | hsa-miR-16-5p | DLL1 | 0.47 | 0.02635 | -0.37 | 0.03112 | miRNATAP | -0.14 | 0.00452 | NA | |
146 | hsa-miR-16-5p | DMD | 0.47 | 0.02635 | -1.51 | 0 | miRNAWalker2 validate | -0.99 | 0 | NA | |
147 | hsa-miR-16-5p | DMTF1 | 0.47 | 0.02635 | 0.25 | 0.02726 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.12 | 0.00016 | NA | |
148 | hsa-miR-16-5p | DNAJA4 | 0.47 | 0.02635 | 0.27 | 0.13216 | miRNAWalker2 validate | -0.12 | 0.0268 | NA | |
149 | hsa-miR-16-5p | DNAJB4 | 0.47 | 0.02635 | -0.7 | 1.0E-5 | miRNAWalker2 validate | -0.45 | 0 | NA | |
150 | hsa-miR-16-5p | DOCK4 | 0.47 | 0.02635 | 0.5 | 0.00108 | MirTarget | -0.21 | 0 | NA |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | NEUROGENESIS | 107 | 1402 | 1.628e-16 | 7.573e-13 |
2 | NEURON DIFFERENTIATION | 73 | 874 | 2.382e-13 | 5.543e-10 |
3 | CELLULAR COMPONENT MORPHOGENESIS | 73 | 900 | 1.005e-12 | 1.559e-09 |
4 | CENTRAL NERVOUS SYSTEM DEVELOPMENT | 71 | 872 | 1.768e-12 | 2.056e-09 |
5 | CELL DEVELOPMENT | 97 | 1426 | 5.446e-12 | 5.068e-09 |
6 | HEAD DEVELOPMENT | 61 | 709 | 7.496e-12 | 5.813e-09 |
7 | NEURON DEVELOPMENT | 59 | 687 | 1.82e-11 | 1.21e-08 |
8 | INTRACELLULAR SIGNAL TRANSDUCTION | 102 | 1572 | 2.302e-11 | 1.339e-08 |
9 | REGULATION OF DEVELOPMENTAL GROWTH | 35 | 289 | 3.244e-11 | 1.677e-08 |
10 | ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS | 72 | 957 | 4.915e-11 | 2.287e-08 |
11 | NEURON PROJECTION DEVELOPMENT | 50 | 545 | 6.796e-11 | 2.474e-08 |
12 | REGULATION OF CELL DIFFERENTIATION | 97 | 1492 | 6.955e-11 | 2.474e-08 |
13 | CARDIOVASCULAR SYSTEM DEVELOPMENT | 63 | 788 | 7.444e-11 | 2.474e-08 |
14 | CIRCULATORY SYSTEM DEVELOPMENT | 63 | 788 | 7.444e-11 | 2.474e-08 |
15 | REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT | 104 | 1672 | 1.644e-10 | 4.781e-08 |
16 | CELL PROJECTION ORGANIZATION | 68 | 902 | 1.628e-10 | 4.781e-08 |
17 | CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION | 47 | 513 | 2.712e-10 | 7.422e-08 |
18 | TISSUE DEVELOPMENT | 96 | 1518 | 3.926e-10 | 1.015e-07 |
19 | PROTEIN PHOSPHORYLATION | 69 | 944 | 4.48e-10 | 1.097e-07 |
20 | REGULATION OF NEURON DIFFERENTIATION | 48 | 554 | 1.133e-09 | 2.635e-07 |
21 | REGULATION OF NERVOUS SYSTEM DEVELOPMENT | 58 | 750 | 1.548e-09 | 3.43e-07 |
22 | POSITIVE REGULATION OF DEVELOPMENTAL PROCESS | 77 | 1142 | 1.646e-09 | 3.482e-07 |
23 | ORGAN MORPHOGENESIS | 61 | 841 | 6.602e-09 | 1.336e-06 |
24 | REGULATION OF NEURON PROJECTION DEVELOPMENT | 38 | 408 | 9.292e-09 | 1.802e-06 |
25 | REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | 102 | 1784 | 2.273e-08 | 4.23e-06 |
26 | ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY | 52 | 689 | 2.534e-08 | 4.535e-06 |
27 | VASCULATURE DEVELOPMENT | 40 | 469 | 4.396e-08 | 7.306e-06 |
28 | POSITIVE REGULATION OF CELL DIFFERENTIATION | 58 | 823 | 4.365e-08 | 7.306e-06 |
29 | EMBRYO DEVELOPMENT | 61 | 894 | 6.127e-08 | 9.83e-06 |
30 | REGULATION OF ION TRANSPORT | 46 | 592 | 7.111e-08 | 1.103e-05 |
31 | REGULATION OF GROWTH | 48 | 633 | 7.717e-08 | 1.122e-05 |
32 | REGULATION OF CELL DEVELOPMENT | 58 | 836 | 7.491e-08 | 1.122e-05 |
33 | PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS | 108 | 1977 | 8.805e-08 | 1.241e-05 |
34 | REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION | 94 | 1656 | 1.241e-07 | 1.699e-05 |
35 | CELLULAR RESPONSE TO ENDOGENOUS STIMULUS | 65 | 1008 | 1.773e-07 | 2.357e-05 |
36 | EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING | 43 | 554 | 1.977e-07 | 2.42e-05 |
37 | CELL PART MORPHOGENESIS | 47 | 633 | 1.966e-07 | 2.42e-05 |
38 | REGULATION OF EXTENT OF CELL GROWTH | 16 | 101 | 1.909e-07 | 2.42e-05 |
39 | POSITIVE REGULATION OF DEVELOPMENTAL GROWTH | 20 | 156 | 2.167e-07 | 2.586e-05 |
40 | HEART DEVELOPMENT | 38 | 466 | 3.015e-07 | 3.507e-05 |
41 | REGULATION OF METAL ION TRANSPORT | 30 | 325 | 4.137e-07 | 4.695e-05 |
42 | REGULATION OF CELL MORPHOGENESIS | 42 | 552 | 4.677e-07 | 5.181e-05 |
43 | REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS | 64 | 1021 | 5.977e-07 | 6.468e-05 |
44 | REGULATION OF CELL PROJECTION ORGANIZATION | 42 | 558 | 6.222e-07 | 6.58e-05 |
45 | PHOSPHORYLATION | 73 | 1228 | 6.935e-07 | 7.17e-05 |
46 | MOVEMENT OF CELL OR SUBCELLULAR COMPONENT | 75 | 1275 | 7.191e-07 | 7.273e-05 |
47 | FOREBRAIN DEVELOPMENT | 31 | 357 | 1e-06 | 9.597e-05 |
48 | SECRETION | 43 | 588 | 9.847e-07 | 9.597e-05 |
49 | CEREBRAL CORTEX CELL MIGRATION | 10 | 43 | 1.011e-06 | 9.597e-05 |
50 | TISSUE MORPHOGENESIS | 40 | 533 | 1.244e-06 | 0.0001157 |
51 | MORPHOGENESIS OF AN EPITHELIUM | 33 | 400 | 1.409e-06 | 0.0001286 |
52 | TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY | 38 | 498 | 1.544e-06 | 0.0001382 |
53 | CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION | 31 | 368 | 1.9e-06 | 0.0001668 |
54 | HEART MORPHOGENESIS | 22 | 212 | 2.15e-06 | 0.0001852 |
55 | SECRETION BY CELL | 37 | 486 | 2.236e-06 | 0.0001892 |
56 | POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT | 23 | 232 | 2.783e-06 | 0.0002312 |
57 | REGULATION OF TRANSPORT | 95 | 1804 | 2.954e-06 | 0.0002411 |
58 | POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT | 34 | 437 | 3.596e-06 | 0.0002752 |
59 | NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH | 13 | 84 | 3.493e-06 | 0.0002752 |
60 | RESPONSE TO ENDOGENOUS STIMULUS | 80 | 1450 | 3.607e-06 | 0.0002752 |
61 | BEHAVIOR | 38 | 516 | 3.586e-06 | 0.0002752 |
62 | REGULATION OF MEMBRANE POTENTIAL | 29 | 343 | 3.78e-06 | 0.0002837 |
63 | EPITHELIUM DEVELOPMENT | 58 | 945 | 3.982e-06 | 0.0002941 |
64 | MEMBRANE DEPOLARIZATION | 11 | 61 | 4.269e-06 | 0.0003047 |
65 | REGULATION OF CELL SIZE | 19 | 172 | 4.215e-06 | 0.0003047 |
66 | NEURON PROJECTION MORPHOGENESIS | 32 | 402 | 4.322e-06 | 0.0003047 |
67 | HINDBRAIN MORPHOGENESIS | 9 | 40 | 4.746e-06 | 0.0003296 |
68 | FOREBRAIN CELL MIGRATION | 11 | 62 | 5.037e-06 | 0.0003447 |
69 | REGULATION OF TRANSMEMBRANE TRANSPORT | 33 | 426 | 5.476e-06 | 0.0003693 |
70 | REGULATION OF BLOOD CIRCULATION | 26 | 295 | 5.668e-06 | 0.0003767 |
71 | REGULATION OF CALCIUM ION TRANSPORT | 21 | 209 | 6.065e-06 | 0.0003975 |
72 | INNERVATION | 7 | 23 | 6.317e-06 | 0.0004082 |
73 | REGULATION OF PHOSPHORUS METABOLIC PROCESS | 86 | 1618 | 6.502e-06 | 0.0004144 |
74 | TUBE DEVELOPMENT | 39 | 552 | 7.124e-06 | 0.0004479 |
75 | MUSCLE STRUCTURE DEVELOPMENT | 33 | 432 | 7.346e-06 | 0.0004558 |
76 | REGULATION OF ANATOMICAL STRUCTURE SIZE | 35 | 472 | 7.478e-06 | 0.0004578 |
77 | REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION | 28 | 337 | 7.699e-06 | 0.0004652 |
78 | SKELETAL SYSTEM DEVELOPMENT | 34 | 455 | 8.566e-06 | 0.000511 |
79 | CEREBRAL CORTEX DEVELOPMENT | 14 | 105 | 8.942e-06 | 0.0005267 |
80 | REGULATION OF TRANSPORTER ACTIVITY | 20 | 198 | 9.283e-06 | 0.0005399 |
81 | POSITIVE REGULATION OF NEURON DIFFERENTIATION | 26 | 306 | 1.09e-05 | 0.0006263 |
82 | HINDBRAIN DEVELOPMENT | 16 | 137 | 1.179e-05 | 0.0006454 |
83 | NEGATIVE REGULATION OF PHOSPHORYLATION | 32 | 422 | 1.17e-05 | 0.0006454 |
84 | CELLULAR MACROMOLECULE LOCALIZATION | 69 | 1234 | 1.154e-05 | 0.0006454 |
85 | REGULATION OF AXONOGENESIS | 18 | 168 | 1.148e-05 | 0.0006454 |
86 | PALLIUM DEVELOPMENT | 17 | 153 | 1.237e-05 | 0.0006692 |
87 | NERVE DEVELOPMENT | 11 | 68 | 1.27e-05 | 0.0006794 |
88 | PEPTIDYL TYROSINE MODIFICATION | 19 | 186 | 1.316e-05 | 0.0006878 |
89 | MULTICELLULAR ORGANISMAL SIGNALING | 15 | 123 | 1.302e-05 | 0.0006878 |
90 | PLASMA MEMBRANE ORGANIZATION | 20 | 203 | 1.345e-05 | 0.0006918 |
91 | ENDOMEMBRANE SYSTEM ORGANIZATION | 34 | 465 | 1.353e-05 | 0.0006918 |
92 | REGULATION OF HEART CONTRACTION | 21 | 221 | 1.436e-05 | 0.0006965 |
93 | POSITIVE REGULATION OF GROWTH | 22 | 238 | 1.398e-05 | 0.0006965 |
94 | REGULATION OF SYSTEM PROCESS | 36 | 507 | 1.437e-05 | 0.0006965 |
95 | BIOLOGICAL ADHESION | 60 | 1032 | 1.422e-05 | 0.0006965 |
96 | INOSITOL LIPID MEDIATED SIGNALING | 15 | 124 | 1.437e-05 | 0.0006965 |
97 | POSITIVE REGULATION OF CELL COMMUNICATION | 81 | 1532 | 1.504e-05 | 0.0007216 |
98 | CELL CELL SIGNALING | 48 | 767 | 1.688e-05 | 0.0008012 |
99 | REGULATION OF PROTEIN MODIFICATION PROCESS | 88 | 1710 | 1.739e-05 | 0.0008172 |
100 | SEMAPHORIN PLEXIN SIGNALING PATHWAY | 8 | 36 | 1.78e-05 | 0.000828 |
101 | NEGATIVE REGULATION OF NEURON DIFFERENTIATION | 19 | 191 | 1.918e-05 | 0.0008798 |
102 | REGULATION OF CELLULAR COMPONENT MOVEMENT | 48 | 771 | 1.929e-05 | 0.0008798 |
103 | RESPONSE TO GROWTH FACTOR | 34 | 475 | 2.101e-05 | 0.0009493 |
104 | NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION | 16 | 144 | 2.215e-05 | 0.0009909 |
105 | NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION | 32 | 437 | 2.346e-05 | 0.00104 |
106 | METENCEPHALON DEVELOPMENT | 13 | 100 | 2.45e-05 | 0.001069 |
107 | NEGATIVE REGULATION OF CELL COMMUNICATION | 66 | 1192 | 2.458e-05 | 0.001069 |
108 | NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS | 49 | 801 | 2.487e-05 | 0.001071 |
109 | NEGATIVE REGULATION OF AXON EXTENSION | 8 | 38 | 2.714e-05 | 0.001127 |
110 | POSITIVE REGULATION OF LOCOMOTION | 31 | 420 | 2.695e-05 | 0.001127 |
111 | SUBSTRATE ADHESION DEPENDENT CELL SPREADING | 8 | 38 | 2.714e-05 | 0.001127 |
112 | PROTEIN LOCALIZATION | 91 | 1805 | 2.696e-05 | 0.001127 |
113 | TUBE MORPHOGENESIS | 26 | 323 | 2.792e-05 | 0.00115 |
114 | CELL SUBSTRATE ADHESION | 17 | 164 | 3.07e-05 | 0.001253 |
115 | MUSCLE CONTRACTION | 21 | 233 | 3.178e-05 | 0.001275 |
116 | BLOOD VESSEL MORPHOGENESIS | 28 | 364 | 3.158e-05 | 0.001275 |
117 | POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS | 74 | 1395 | 3.259e-05 | 0.001296 |
118 | MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL | 8 | 39 | 3.316e-05 | 0.001297 |
119 | REGULATION OF AXON GUIDANCE | 8 | 39 | 3.316e-05 | 0.001297 |
120 | REGULATION OF CELL PROLIFERATION | 78 | 1496 | 3.541e-05 | 0.001373 |
121 | CYTOSKELETON ORGANIZATION | 50 | 838 | 3.915e-05 | 0.001505 |
122 | IN UTERO EMBRYONIC DEVELOPMENT | 25 | 311 | 4.051e-05 | 0.001545 |
123 | ACTIN FILAMENT BASED PROCESS | 32 | 450 | 4.148e-05 | 0.001569 |
124 | SENSORY ORGAN DEVELOPMENT | 34 | 493 | 4.459e-05 | 0.001673 |
125 | POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | 57 | 1004 | 4.559e-05 | 0.001697 |
126 | NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS | 36 | 541 | 5.625e-05 | 0.002061 |
127 | NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS | 36 | 541 | 5.625e-05 | 0.002061 |
128 | REGULATION OF CELLULAR COMPONENT SIZE | 26 | 337 | 5.71e-05 | 0.002076 |
129 | MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL | 5 | 14 | 5.98e-05 | 0.002137 |
130 | ACTION POTENTIAL | 12 | 94 | 5.994e-05 | 0.002137 |
131 | PROTEIN DEPHOSPHORYLATION | 18 | 190 | 6.017e-05 | 0.002137 |
132 | REGULATION OF CATION TRANSMEMBRANE TRANSPORT | 19 | 208 | 6.23e-05 | 0.002196 |
133 | NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS | 60 | 1087 | 6.371e-05 | 0.002229 |
134 | MUSCLE SYSTEM PROCESS | 23 | 282 | 6.531e-05 | 0.002268 |
135 | NEURON MIGRATION | 13 | 110 | 6.765e-05 | 0.002332 |
136 | LOCOMOTION | 61 | 1114 | 6.931e-05 | 0.002371 |
137 | REGULATION OF BODY FLUID LEVELS | 34 | 506 | 7.447e-05 | 0.002529 |
138 | EXTRACELLULAR STRUCTURE ORGANIZATION | 24 | 304 | 7.625e-05 | 0.002571 |
139 | NEGATIVE REGULATION OF RESPONSE TO STIMULUS | 71 | 1360 | 7.826e-05 | 0.00262 |
140 | SINGLE ORGANISM BEHAVIOR | 28 | 384 | 8.061e-05 | 0.002679 |
141 | POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT | 9 | 56 | 8.22e-05 | 0.002693 |
142 | NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS | 39 | 616 | 8.167e-05 | 0.002693 |
143 | REGULATION OF HOMEOSTATIC PROCESS | 31 | 447 | 8.654e-05 | 0.002816 |
144 | NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS | 55 | 983 | 9.117e-05 | 0.002946 |
145 | CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT | 10 | 70 | 9.396e-05 | 0.003015 |
146 | CYCLIC NUCLEOTIDE METABOLIC PROCESS | 9 | 57 | 9.479e-05 | 0.003021 |
147 | FOREBRAIN NEURON DEVELOPMENT | 7 | 34 | 0.0001011 | 0.003179 |
148 | CAMP METABOLIC PROCESS | 7 | 34 | 0.0001011 | 0.003179 |
149 | REGULATION OF CELL GROWTH | 28 | 391 | 0.0001097 | 0.003426 |
150 | ESTABLISHMENT OF LOCALIZATION IN CELL | 83 | 1676 | 0.0001157 | 0.003563 |
151 | EMBRYONIC MORPHOGENESIS | 35 | 539 | 0.0001151 | 0.003563 |
152 | ANGIOGENESIS | 23 | 293 | 0.0001164 | 0.003563 |
153 | POSITIVE REGULATION OF BIOSYNTHETIC PROCESS | 88 | 1805 | 0.0001218 | 0.003704 |
154 | CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION | 16 | 166 | 0.0001244 | 0.003758 |
155 | POSITIVE REGULATION OF GENE EXPRESSION | 85 | 1733 | 0.0001315 | 0.003948 |
156 | SINGLE ORGANISM CELL ADHESION | 31 | 459 | 0.0001397 | 0.00414 |
157 | MESENCHYMAL CELL DIFFERENTIATION | 14 | 134 | 0.0001388 | 0.00414 |
158 | REGULATION OF CATION CHANNEL ACTIVITY | 11 | 88 | 0.0001463 | 0.004307 |
159 | POSITIVE REGULATION OF AXON EXTENSION | 7 | 36 | 0.0001482 | 0.004337 |
160 | CELL GROWTH | 14 | 135 | 0.0001503 | 0.00437 |
161 | REGULATED EXOCYTOSIS | 19 | 224 | 0.0001663 | 0.004806 |
162 | NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT | 21 | 262 | 0.0001706 | 0.00484 |
163 | CELLULAR RESPONSE TO ORGANIC SUBSTANCE | 89 | 1848 | 0.0001692 | 0.00484 |
164 | MYELIN ASSEMBLY | 5 | 17 | 0.0001702 | 0.00484 |
165 | NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION | 41 | 684 | 0.000176 | 0.004963 |
166 | AXON EXTENSION | 7 | 37 | 0.0001776 | 0.004979 |
167 | POSITIVE REGULATION OF RESPONSE TO STIMULUS | 92 | 1929 | 0.0001825 | 0.005053 |
168 | PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS | 8 | 49 | 0.0001819 | 0.005053 |
169 | NEGATIVE REGULATION OF CELL DEVELOPMENT | 23 | 303 | 0.0001909 | 0.005225 |
170 | POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION | 23 | 303 | 0.0001909 | 0.005225 |
171 | NEGATIVE REGULATION OF AXON GUIDANCE | 6 | 27 | 0.0002048 | 0.005574 |
172 | TELENCEPHALON DEVELOPMENT | 19 | 228 | 0.000209 | 0.005654 |
173 | REGULATION OF SEQUESTERING OF CALCIUM ION | 12 | 107 | 0.000211 | 0.005676 |
174 | DEPHOSPHORYLATION | 22 | 286 | 0.0002167 | 0.00578 |
175 | PROTEIN AUTOPHOSPHORYLATION | 17 | 192 | 0.0002174 | 0.00578 |
176 | MEMBRANE ORGANIZATION | 50 | 899 | 0.0002193 | 0.005797 |
177 | REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS | 19 | 229 | 0.0002211 | 0.005811 |
178 | POSITIVE REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC | 5 | 18 | 0.0002293 | 0.005962 |
179 | POSITIVE REGULATION OF CELL DEVELOPMENT | 31 | 472 | 0.0002288 | 0.005962 |
180 | CONNECTIVE TISSUE DEVELOPMENT | 17 | 194 | 0.0002459 | 0.006356 |
181 | REGULATION OF GTPASE ACTIVITY | 40 | 673 | 0.0002504 | 0.006438 |
182 | COGNITION | 20 | 251 | 0.0002612 | 0.00664 |
183 | REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY | 19 | 232 | 0.000261 | 0.00664 |
184 | EXOCYTOSIS | 23 | 310 | 0.0002657 | 0.006705 |
185 | NEGATIVE REGULATION OF AXONOGENESIS | 9 | 65 | 0.0002666 | 0.006705 |
186 | SECOND MESSENGER MEDIATED SIGNALING | 15 | 160 | 0.0002716 | 0.006794 |
187 | CELLULAR RESPONSE TO OXYGEN LEVELS | 14 | 143 | 0.0002754 | 0.006852 |
188 | DEVELOPMENTAL GROWTH | 24 | 333 | 0.0003027 | 0.007492 |
189 | GLAND DEVELOPMENT | 27 | 395 | 0.0003057 | 0.007526 |
190 | CEREBRAL CORTEX RADIALLY ORIENTED CELL MIGRATION | 6 | 29 | 0.0003108 | 0.007611 |
191 | POSITIVE REGULATION OF NEURON MIGRATION | 4 | 11 | 0.0003204 | 0.007804 |
192 | CELL JUNCTION ASSEMBLY | 13 | 129 | 0.0003398 | 0.008235 |
193 | MUSCLE CELL DIFFERENTIATION | 19 | 237 | 0.0003416 | 0.008236 |
194 | MUSCLE ORGAN DEVELOPMENT | 21 | 277 | 0.0003633 | 0.008714 |
195 | CARTILAGE DEVELOPMENT | 14 | 147 | 0.000366 | 0.008733 |
196 | PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL | 48 | 873 | 0.0003781 | 0.008841 |
197 | CEREBELLAR CORTEX MORPHOGENESIS | 6 | 30 | 0.0003778 | 0.008841 |
198 | REGULATION OF ION HOMEOSTASIS | 17 | 201 | 0.0003728 | 0.008841 |
199 | ORGAN GROWTH | 9 | 68 | 0.0003765 | 0.008841 |
200 | CEREBRAL CORTEX RADIAL GLIA GUIDED MIGRATION | 5 | 20 | 0.0003929 | 0.009005 |
201 | TELENCEPHALON GLIAL CELL MIGRATION | 5 | 20 | 0.0003929 | 0.009005 |
202 | PROTEIN STABILIZATION | 13 | 131 | 0.0003948 | 0.009005 |
203 | REGULATION OF POTASSIUM ION TRANSPORT | 10 | 83 | 0.0003928 | 0.009005 |
204 | SINGLE ORGANISM CELLULAR LOCALIZATION | 49 | 898 | 0.000391 | 0.009005 |
205 | MODULATION OF SYNAPTIC TRANSMISSION | 22 | 301 | 0.0004398 | 0.009982 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | PROTEIN KINASE ACTIVITY | 54 | 640 | 2.626e-10 | 2.439e-07 |
2 | CYTOSKELETAL PROTEIN BINDING | 59 | 819 | 1.517e-08 | 5.232e-06 |
3 | KINASE ACTIVITY | 60 | 842 | 1.689e-08 | 5.232e-06 |
4 | RIBONUCLEOTIDE BINDING | 100 | 1860 | 6.072e-07 | 0.000141 |
5 | TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS | 62 | 992 | 9.996e-07 | 0.0001857 |
6 | ENZYME BINDING | 93 | 1737 | 1.91e-06 | 0.0002958 |
7 | TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY | 13 | 81 | 2.294e-06 | 0.0003044 |
8 | PROTEIN TYROSINE KINASE ACTIVITY | 19 | 176 | 5.913e-06 | 0.0006866 |
9 | ACTIN BINDING | 31 | 393 | 7.315e-06 | 0.0007551 |
10 | ZINC ION BINDING | 66 | 1155 | 9.085e-06 | 0.0008283 |
11 | ADENYL NUCLEOTIDE BINDING | 81 | 1514 | 9.808e-06 | 0.0008283 |
12 | VOLTAGE GATED ION CHANNEL ACTIVITY | 19 | 190 | 1.781e-05 | 0.00137 |
13 | TRANSITION METAL ION BINDING | 75 | 1400 | 2.064e-05 | 0.00137 |
14 | MACROMOLECULAR COMPLEX BINDING | 75 | 1399 | 2.015e-05 | 0.00137 |
15 | PROTEIN COMPLEX BINDING | 55 | 935 | 2.377e-05 | 0.001472 |
16 | TUBULIN BINDING | 23 | 273 | 3.959e-05 | 0.002163 |
17 | PDZ DOMAIN BINDING | 12 | 90 | 3.875e-05 | 0.002163 |
18 | TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY | 10 | 64 | 4.283e-05 | 0.002211 |
19 | UBIQUITIN LIKE PROTEIN CONJUGATING ENZYME BINDING | 7 | 34 | 0.0001011 | 0.004944 |
20 | CHANNEL REGULATOR ACTIVITY | 14 | 131 | 0.0001088 | 0.005055 |
21 | MICROTUBULE BINDING | 18 | 201 | 0.0001242 | 0.005495 |
22 | CALCIUM ION BINDING | 42 | 697 | 0.0001313 | 0.005542 |
23 | MOLECULAR FUNCTION REGULATOR | 69 | 1353 | 0.0001972 | 0.007299 |
24 | CORECEPTOR ACTIVITY | 7 | 38 | 0.0002116 | 0.007299 |
25 | PROTEIN SERINE THREONINE KINASE ACTIVITY | 30 | 445 | 0.0001838 | 0.007299 |
26 | CHEMOREPELLENT ACTIVITY | 6 | 27 | 0.0002048 | 0.007299 |
27 | GROWTH FACTOR BINDING | 13 | 123 | 0.0002121 | 0.007299 |
28 | KINASE BINDING | 37 | 606 | 0.0002531 | 0.008398 |
29 | PHOSPHOPROTEIN PHOSPHATASE ACTIVITY | 16 | 178 | 0.0002782 | 0.008913 |
30 | METAL ION TRANSMEMBRANE TRANSPORTER ACTIVITY | 28 | 417 | 0.000318 | 0.009847 |
31 | PHOSPHATASE ACTIVITY | 21 | 275 | 0.0003298 | 0.009883 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | NEURON PART | 91 | 1265 | 1.266e-12 | 7.392e-10 |
2 | NEURON PROJECTION | 71 | 942 | 6.252e-11 | 1.826e-08 |
3 | CELL PROJECTION | 109 | 1786 | 1.68e-10 | 3.271e-08 |
4 | CYTOSKELETON | 109 | 1967 | 3.606e-08 | 5.265e-06 |
5 | SOMATODENDRITIC COMPARTMENT | 49 | 650 | 6.741e-08 | 7.874e-06 |
6 | SYNAPSE | 52 | 754 | 4.379e-07 | 4.263e-05 |
7 | CATION CHANNEL COMPLEX | 20 | 167 | 6.588e-07 | 5.496e-05 |
8 | CELL JUNCTION | 69 | 1151 | 1.067e-06 | 7.787e-05 |
9 | DENDRITE | 35 | 451 | 2.741e-06 | 0.0001779 |
10 | SARCOLEMMA | 16 | 125 | 3.577e-06 | 0.0002089 |
11 | CELL PROJECTION PART | 56 | 946 | 1.673e-05 | 0.0008882 |
12 | PLASMA MEMBRANE RAFT | 12 | 86 | 2.438e-05 | 0.001187 |
13 | MICROTUBULE CYTOSKELETON | 60 | 1068 | 3.869e-05 | 0.001329 |
14 | MICROTUBULE | 30 | 405 | 3.388e-05 | 0.001329 |
15 | MEMBRANE MICRODOMAIN | 24 | 288 | 3.231e-05 | 0.001329 |
16 | ANCHORING JUNCTION | 34 | 489 | 3.789e-05 | 0.001329 |
17 | PLASMA MEMBRANE PROTEIN COMPLEX | 35 | 510 | 3.82e-05 | 0.001329 |
18 | CELL SUBSTRATE JUNCTION | 29 | 398 | 6.123e-05 | 0.001987 |
19 | EXTRACELLULAR MATRIX COMPONENT | 14 | 125 | 6.525e-05 | 0.002006 |
20 | EXCITATORY SYNAPSE | 18 | 197 | 9.612e-05 | 0.002715 |
21 | T TUBULE | 8 | 45 | 9.762e-05 | 0.002715 |
22 | CELL BODY | 33 | 494 | 0.0001057 | 0.002807 |
23 | PROTEINACEOUS EXTRACELLULAR MATRIX | 26 | 356 | 0.0001397 | 0.003548 |
24 | PRIMARY CILIUM | 18 | 205 | 0.0001593 | 0.003876 |
25 | BASEMENT MEMBRANE | 11 | 93 | 0.0002402 | 0.00561 |
26 | COSTAMERE | 5 | 19 | 0.0003029 | 0.006802 |
27 | POSTSYNAPSE | 26 | 378 | 0.0003569 | 0.007443 |
28 | MEMBRANE REGION | 59 | 1134 | 0.0003505 | 0.007443 |
29 | CYTOSKELETAL PART | 71 | 1436 | 0.0003891 | 0.007836 |
30 | EXTRACELLULAR MATRIX | 28 | 426 | 0.000447 | 0.008702 |
31 | PLASMA MEMBRANE REGION | 50 | 929 | 0.0004668 | 0.008794 |
Num | Pathway | Pathview | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|---|
1 | Focal_adhesion_hsa04510 | 25 | 199 | 1.021e-08 | 5.309e-07 | |
2 | MAPK_signaling_pathway_hsa04010 | 27 | 295 | 1.839e-06 | 4.782e-05 | |
3 | Regulation_of_actin_cytoskeleton_hsa04810 | 21 | 208 | 5.626e-06 | 9.751e-05 | |
4 | Rap1_signaling_pathway_hsa04015 | 19 | 206 | 5.465e-05 | 0.0007105 | |
5 | Autophagy_animal_hsa04140 | 14 | 128 | 8.463e-05 | 0.0008456 | |
6 | cGMP_PKG_signaling_pathway_hsa04022 | 16 | 163 | 0.0001003 | 0.0008456 | |
7 | Calcium_signaling_pathway_hsa04020 | 17 | 182 | 0.0001138 | 0.0008456 | |
8 | mTOR_signaling_pathway_hsa04150 | 15 | 151 | 0.0001434 | 0.0009323 | |
9 | Oocyte_meiosis_hsa04114 | 13 | 124 | 0.00023 | 0.001329 | |
10 | Hippo_signaling_pathway_multiple_species_hsa04392 | 6 | 29 | 0.0003108 | 0.001616 | |
11 | ECM_receptor_interaction_hsa04512 | 10 | 82 | 0.0003558 | 0.001682 | |
12 | PI3K_Akt_signaling_pathway_hsa04151 | 24 | 352 | 0.0006709 | 0.002907 | |
13 | ErbB_signaling_pathway_hsa04012 | 9 | 85 | 0.001919 | 0.007209 | |
14 | Apelin_signaling_pathway_hsa04371 | 12 | 137 | 0.001941 | 0.007209 | |
15 | Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 | 12 | 139 | 0.002193 | 0.007602 | |
16 | cAMP_signaling_pathway_hsa04024 | 15 | 198 | 0.00242 | 0.007864 | |
17 | Ras_signaling_pathway_hsa04014 | 16 | 232 | 0.004476 | 0.01369 | |
18 | AMPK_signaling_pathway_hsa04152 | 10 | 121 | 0.006733 | 0.01945 | |
19 | Gap_junction_hsa04540 | 8 | 88 | 0.008474 | 0.02319 | |
20 | Wnt_signaling_pathway_hsa04310 | 11 | 146 | 0.009067 | 0.02339 | |
21 | Adherens_junction_hsa04520 | 7 | 72 | 0.009446 | 0.02339 | |
22 | FoxO_signaling_pathway_hsa04068 | 10 | 132 | 0.01208 | 0.02855 | |
23 | Phosphatidylinositol_signaling_system_hsa04070 | 8 | 99 | 0.01653 | 0.03737 | |
24 | HIF_1_signaling_pathway_hsa04066 | 8 | 100 | 0.01747 | 0.03785 | |
25 | Jak_STAT_signaling_pathway_hsa04630 | 11 | 162 | 0.01858 | 0.03866 | |
26 | Mitophagy_animal_hsa04137 | 6 | 65 | 0.01997 | 0.03994 | |
27 | Phospholipase_D_signaling_pathway_hsa04072 | 10 | 146 | 0.02289 | 0.04408 | |
28 | Hippo_signaling_pathway_hsa04390 | 10 | 154 | 0.03155 | 0.05859 | |
29 | Hedgehog_signaling_pathway_hsa04340 | 4 | 47 | 0.06845 | 0.1227 | |
30 | p53_signaling_pathway_hsa04115 | 5 | 68 | 0.07332 | 0.1271 | |
31 | Cellular_senescence_hsa04218 | 9 | 160 | 0.083 | 0.1392 | |
32 | Endocytosis_hsa04144 | 12 | 244 | 0.1098 | 0.1785 | |
33 | VEGF_signaling_pathway_hsa04370 | 4 | 59 | 0.1295 | 0.2041 | |
34 | TNF_signaling_pathway_hsa04668 | 6 | 108 | 0.1464 | 0.2239 | |
35 | Tight_junction_hsa04530 | 8 | 170 | 0.1994 | 0.2926 | |
36 | Cell_adhesion_molecules_.CAMs._hsa04514 | 7 | 145 | 0.2026 | 0.2926 | |
37 | Notch_signaling_pathway_hsa04330 | 3 | 48 | 0.2099 | 0.295 | |
38 | Apoptosis_hsa04210 | 6 | 138 | 0.3035 | 0.4153 | |
39 | Phagosome_hsa04145 | 6 | 152 | 0.3855 | 0.514 | |
40 | ABC_transporters_hsa02010 | 2 | 45 | 0.4393 | 0.5711 | |
41 | TGF_beta_signaling_pathway_hsa04350 | 3 | 84 | 0.5263 | 0.6675 | |
42 | Sphingolipid_signaling_pathway_hsa04071 | 4 | 118 | 0.5479 | 0.6783 | |
43 | NF_kappa_B_signaling_pathway_hsa04064 | 3 | 95 | 0.61 | 0.7376 | |
44 | Cell_cycle_hsa04110 | 3 | 124 | 0.78 | 0.863 | |
45 | Neuroactive_ligand_receptor_interaction_hsa04080 | 6 | 278 | 0.8992 | 0.9741 | |
46 | Cytokine_cytokine_receptor_interaction_hsa04060 | 5 | 270 | 0.9455 | 0.9833 | |
47 | Necroptosis_hsa04217 | 2 | 164 | 0.9734 | 0.984 |