This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are
presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.
"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.
Num | microRNA | Gene | miRNA log2FC | miRNA pvalue | Gene log2FC | Gene pvalue | Interaction | Correlation beta | Correlation P-value | PMID | Reported in cancer studies |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | hsa-miR-137 | ACTBL2 | -0.08 | 0.93052 | 1.45 | 0.14365 | miRanda | -0.2 | 0.02175 | NA | |
2 | hsa-miR-137 | AGR3 | -0.08 | 0.93052 | 4.01 | 0.00125 | miRanda | -0.25 | 0.02171 | NA | |
3 | hsa-miR-137 | AMOT | -0.08 | 0.93052 | 0.06 | 0.88976 | miRanda; mirMAP | -0.11 | 0.00201 | NA | |
4 | hsa-miR-137 | ANKRD22 | -0.08 | 0.93052 | 1.13 | 0.17977 | miRanda | -0.19 | 0.00722 | NA | |
5 | hsa-miR-137 | APOBEC1 | -0.08 | 0.93052 | 4.29 | 0.00238 | miRanda | -0.29 | 0.01725 | NA | |
6 | hsa-miR-137 | ASPH | -0.08 | 0.93052 | 0.98 | 0.03201 | MirTarget; PITA; miRanda; miRNATAP | -0.14 | 0.00031 | NA | |
7 | hsa-miR-137 | ATP10B | -0.08 | 0.93052 | 2.38 | 0.05795 | miRanda | -0.43 | 6.0E-5 | NA | |
8 | hsa-miR-137 | ATP1B1 | -0.08 | 0.93052 | 1.43 | 0.00225 | PITA; miRanda; miRNATAP | -0.13 | 0.00165 | NA | |
9 | hsa-miR-137 | B4GALNT2 | -0.08 | 0.93052 | 0.09 | 0.94128 | miRanda | -0.28 | 0.00975 | NA | |
10 | hsa-miR-137 | CASP7 | -0.08 | 0.93052 | 0.21 | 0.50664 | miRanda | -0.12 | 1.0E-5 | NA | |
11 | hsa-miR-137 | CD55 | -0.08 | 0.93052 | 1.28 | 0.03321 | miRanda | -0.14 | 0.0064 | NA | |
12 | hsa-miR-137 | CDC6 | -0.08 | 0.93052 | 1.47 | 0.00558 | miRanda | -0.12 | 0.00825 | NA | |
13 | hsa-miR-137 | CDCA2 | -0.08 | 0.93052 | 0.79 | 0.2076 | miRanda | -0.13 | 0.0148 | NA | |
14 | hsa-miR-137 | CDCA7L | -0.08 | 0.93052 | -0.03 | 0.95412 | miRNATAP | -0.12 | 0.00504 | NA | |
15 | hsa-miR-137 | CDK6 | -0.08 | 0.93052 | 0.11 | 0.76976 | miRNAWalker2 validate; miRTarBase; PITA; miRNATAP | -0.11 | 0.00051 | 25342326; 18577219; 23178712; 21051724 | Bioinformatics prediction and luciferase reporter assay revealed CDK6 as a target gene through which miR-137 exerted an inhibitory function;Transfection of microRNA-124 or microRNA-137 also induced G1 cell cycle arrest in U251 and SF6969 glioblastoma multiforme cells which was associated with decreased expression of cyclin-dependent kinase 6 and phosphorylated retinoblastoma pSer 807/811 proteins;miR 137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6; Ectopic expression of miR-137 in lung cancer cells significantly downregulated Cdc42 Cdk6 and induced G1 cell cycle arrest leading to a significant decrease in cell growth in vivo and in vitro; Further both Cdc42 and Cdk6 were confirmed as targets of miR-137;The results showed that miR-137 can act as a tumor suppressor in uveal melanoma cell proliferation through downregulation of the targets MITF and CDK6 miR-137 may be epigenetically silenced during uveal melanoma tumorigenesis |
16 | hsa-miR-137 | CENPE | -0.08 | 0.93052 | 0.69 | 0.21533 | miRanda | -0.15 | 0.00159 | NA | |
17 | hsa-miR-137 | CHPT1 | -0.08 | 0.93052 | 0.37 | 0.35447 | miRanda | -0.1 | 0.00335 | NA | |
18 | hsa-miR-137 | CLIC6 | -0.08 | 0.93052 | -0.84 | 0.21863 | miRanda | -0.18 | 0.00245 | NA | |
19 | hsa-miR-137 | CLSPN | -0.08 | 0.93052 | 0.41 | 0.57124 | miRanda | -0.19 | 0.00167 | NA | |
20 | hsa-miR-137 | COL4A5 | -0.08 | 0.93052 | 0.15 | 0.79476 | PITA; miRanda | -0.11 | 0.03182 | NA | |
21 | hsa-miR-137 | DENND1B | -0.08 | 0.93052 | -0.04 | 0.93862 | mirMAP; miRNATAP | -0.19 | 1.0E-5 | NA | |
22 | hsa-miR-137 | DKK1 | -0.08 | 0.93052 | 2.08 | 0.13092 | miRanda | -0.36 | 0.00235 | NA | |
23 | hsa-miR-137 | DOCK5 | -0.08 | 0.93052 | 0.01 | 0.97929 | miRanda | -0.14 | 0.00313 | NA | |
24 | hsa-miR-137 | DTL | -0.08 | 0.93052 | 1.01 | 0.05737 | miRanda | -0.16 | 0.00049 | NA | |
25 | hsa-miR-137 | DUSP10 | -0.08 | 0.93052 | 0.14 | 0.74338 | miRNATAP | -0.12 | 0.00082 | NA | |
26 | hsa-miR-137 | E2F7 | -0.08 | 0.93052 | 0.87 | 0.2158 | PITA; miRanda | -0.17 | 0.00533 | NA | |
27 | hsa-miR-137 | ECT2 | -0.08 | 0.93052 | 1.43 | 0.00432 | miRanda | -0.12 | 0.00683 | NA | |
28 | hsa-miR-137 | ENC1 | -0.08 | 0.93052 | -0.13 | 0.79858 | miRanda | -0.1 | 0.01498 | NA | |
29 | hsa-miR-137 | ERAP2 | -0.08 | 0.93052 | -0.12 | 0.8847 | miRanda | -0.15 | 0.03781 | NA | |
30 | hsa-miR-137 | ERBB3 | -0.08 | 0.93052 | 3.09 | 0 | miRanda | -0.14 | 0.02002 | NA | |
31 | hsa-miR-137 | ERGIC1 | -0.08 | 0.93052 | 0.13 | 0.58748 | miRanda | -0.11 | 0 | NA | |
32 | hsa-miR-137 | EXO1 | -0.08 | 0.93052 | 0.73 | 0.23077 | PITA; miRanda | -0.19 | 0.00029 | NA | |
33 | hsa-miR-137 | EZH2 | -0.08 | 0.93052 | 0.15 | 0.69427 | miRanda; miRNATAP | -0.1 | 0.00153 | 25939439 | MiR 137 inhibits proliferation and angiogenesis of human glioblastoma cells by targeting EZH2; EZH2 was identified as a direct target of miR-137 by using luciferase reporter and Western blot assays and EZH2 overexpression can rescue the inhibitory effect of miR-137 on cell proliferation and angiogenesis; Furthermore tumor samples from GBM patients showed an inverse relationship between miR-137 and EZH2 levels |
34 | hsa-miR-137 | FANCA | -0.08 | 0.93052 | 0.32 | 0.57691 | miRanda | -0.13 | 0.00924 | NA | |
35 | hsa-miR-137 | FERMT1 | -0.08 | 0.93052 | 2.37 | 0.00699 | miRanda | -0.24 | 0.00125 | NA | |
36 | hsa-miR-137 | FLRT3 | -0.08 | 0.93052 | 0.44 | 0.53529 | miRanda | -0.19 | 0.00181 | NA | |
37 | hsa-miR-137 | FOXF1 | -0.08 | 0.93052 | 0.81 | 0.13344 | miRanda | -0.11 | 0.01729 | NA | |
38 | hsa-miR-137 | FRAS1 | -0.08 | 0.93052 | 0.22 | 0.75194 | miRanda | -0.2 | 0.00058 | NA | |
39 | hsa-miR-137 | FREM2 | -0.08 | 0.93052 | 0.19 | 0.85046 | miRanda; mirMAP | -0.25 | 0.00315 | NA | |
40 | hsa-miR-137 | GALNT5 | -0.08 | 0.93052 | 3.38 | 0.0047 | miRanda | -0.31 | 0.00297 | NA | |
41 | hsa-miR-137 | GATM | -0.08 | 0.93052 | -0.47 | 0.60767 | miRanda | -0.17 | 0.0332 | NA | |
42 | hsa-miR-137 | GBP3 | -0.08 | 0.93052 | -0.07 | 0.92197 | MirTarget; miRanda; miRNATAP | -0.21 | 0.00061 | NA | |
43 | hsa-miR-137 | GDA | -0.08 | 0.93052 | 2.64 | 0.01236 | miRanda | -0.33 | 0.00025 | NA | |
44 | hsa-miR-137 | GINS1 | -0.08 | 0.93052 | 0.46 | 0.32951 | miRanda | -0.11 | 0.00924 | NA | |
45 | hsa-miR-137 | GPR157 | -0.08 | 0.93052 | 0.08 | 0.88757 | mirMAP | -0.11 | 0.0255 | NA | |
46 | hsa-miR-137 | GPR37 | -0.08 | 0.93052 | -1.31 | 0.12271 | miRanda | -0.16 | 0.03212 | NA | |
47 | hsa-miR-137 | GPRC5A | -0.08 | 0.93052 | 3.96 | 0.00162 | miRanda | -0.29 | 0.00831 | NA | |
48 | hsa-miR-137 | GREM1 | -0.08 | 0.93052 | 1.25 | 0.2658 | MirTarget; PITA; miRanda | -0.23 | 0.01669 | NA | |
49 | hsa-miR-137 | GULP1 | -0.08 | 0.93052 | 0.45 | 0.34504 | MirTarget; miRanda | -0.1 | 0.01391 | NA | |
50 | hsa-miR-137 | HMGA2 | -0.08 | 0.93052 | 2.01 | 0.08779 | MirTarget; PITA; miRanda | -0.3 | 0.00247 | NA | |
51 | hsa-miR-137 | HOXD10 | -0.08 | 0.93052 | 2.78 | 0.01225 | miRanda; miRNATAP | -0.19 | 0.04707 | NA | |
52 | hsa-miR-137 | HPGD | -0.08 | 0.93052 | 1.42 | 0.09548 | miRanda | -0.16 | 0.02511 | NA | |
53 | hsa-miR-137 | HS3ST3B1 | -0.08 | 0.93052 | -0.6 | 0.33145 | miRanda | -0.11 | 0.03371 | NA | |
54 | hsa-miR-137 | IDE | -0.08 | 0.93052 | 0.09 | 0.79323 | miRanda; mirMAP | -0.1 | 0.00061 | NA | |
55 | hsa-miR-137 | IMPA2 | -0.08 | 0.93052 | 0.45 | 0.40944 | miRanda; miRNATAP | -0.15 | 0.00115 | NA | |
56 | hsa-miR-137 | ITGAV | -0.08 | 0.93052 | -0.33 | 0.42648 | MirTarget; miRanda; mirMAP | -0.12 | 0.00084 | NA | |
57 | hsa-miR-137 | ITPR3 | -0.08 | 0.93052 | 0.61 | 0.2572 | MirTarget; miRanda | -0.14 | 0.00261 | NA | |
58 | hsa-miR-137 | JPH1 | -0.08 | 0.93052 | 2.34 | 4.0E-5 | miRanda | -0.14 | 0.00409 | NA | |
59 | hsa-miR-137 | KCNK1 | -0.08 | 0.93052 | 2.33 | 9.0E-5 | miRanda | -0.15 | 0.0034 | NA | |
60 | hsa-miR-137 | KDELR3 | -0.08 | 0.93052 | 1.57 | 0.00197 | miRanda | -0.18 | 3.0E-5 | NA | |
61 | hsa-miR-137 | KIAA1217 | -0.08 | 0.93052 | 0.15 | 0.72848 | miRanda | -0.1 | 0.00487 | NA | |
62 | hsa-let-7a-3p | KLF12 | -0.95 | 0.00672 | -1.06 | 0.01138 | MirTarget | -0.27 | 0.00277 | NA | |
63 | hsa-miR-130b-3p | KLF12 | -0.37 | 0.37726 | -1.06 | 0.01138 | mirMAP | -0.21 | 0.00417 | NA | |
64 | hsa-miR-141-3p | KLF12 | 1.13 | 0.09667 | -1.06 | 0.01138 | MirTarget; TargetScan | -0.26 | 0 | NA | |
65 | hsa-miR-16-2-3p | KLF12 | -1.03 | 0.00735 | -1.06 | 0.01138 | mirMAP | -0.22 | 0.00765 | NA | |
66 | hsa-miR-192-3p | KLF12 | 1.99 | 0.00569 | -1.06 | 0.01138 | mirMAP | -0.28 | 0 | NA | |
67 | hsa-miR-194-5p | KLF12 | 2.55 | 0.00024 | -1.06 | 0.01138 | MirTarget | -0.25 | 0 | NA | |
68 | hsa-miR-19b-1-5p | KLF12 | -0.14 | 0.71996 | -1.06 | 0.01138 | mirMAP | -0.19 | 0.02466 | NA | |
69 | hsa-miR-200a-3p | KLF12 | 1.69 | 0.00872 | -1.06 | 0.01138 | MirTarget | -0.25 | 0 | NA | |
70 | hsa-miR-200a-5p | KLF12 | 2.65 | 1.0E-5 | -1.06 | 0.01138 | mirMAP | -0.21 | 2.0E-5 | NA | |
71 | hsa-miR-200b-3p | KLF12 | 1.84 | 0.00297 | -1.06 | 0.01138 | TargetScan | -0.28 | 0 | NA | |
72 | hsa-miR-200b-5p | KLF12 | 0.86 | 0.18327 | -1.06 | 0.01138 | mirMAP | -0.27 | 0 | NA | |
73 | hsa-miR-27b-3p | KLF12 | -0.44 | 0.12801 | -1.06 | 0.01138 | mirMAP | -0.32 | 0.0033 | NA | |
74 | hsa-miR-30b-5p | KLF12 | -0.68 | 0.07316 | -1.06 | 0.01138 | MirTarget; mirMAP | -0.28 | 0.00066 | NA | |
75 | hsa-miR-30d-5p | KLF12 | -0.01 | 0.97473 | -1.06 | 0.01138 | MirTarget; mirMAP | -0.23 | 0.03473 | NA | |
76 | hsa-miR-32-5p | KLF12 | -1.17 | 0.00457 | -1.06 | 0.01138 | mirMAP | -0.21 | 0.00432 | NA | |
77 | hsa-miR-362-3p | KLF12 | -1.21 | 0.01257 | -1.06 | 0.01138 | PITA; miRNATAP | -0.15 | 0.02093 | NA | |
78 | hsa-miR-429 | KLF12 | 1.86 | 0.00726 | -1.06 | 0.01138 | PITA; miRNATAP | -0.26 | 0 | NA | |
79 | hsa-miR-137 | KLF5 | -0.08 | 0.93052 | 2.53 | 0.00055 | miRanda | -0.16 | 0.01023 | NA | |
80 | hsa-miR-137 | LPGAT1 | -0.08 | 0.93052 | -0.15 | 0.61899 | mirMAP | -0.12 | 0 | NA | |
81 | hsa-miR-137 | LPP | -0.08 | 0.93052 | 0.05 | 0.92861 | mirMAP | -0.12 | 0.00889 | NA | |
82 | hsa-miR-137 | LRRN1 | -0.08 | 0.93052 | -0.03 | 0.97151 | miRanda | -0.17 | 0.01078 | NA | |
83 | hsa-miR-137 | LYPD6 | -0.08 | 0.93052 | 0.45 | 0.54131 | miRanda; mirMAP | -0.19 | 0.00324 | NA | |
84 | hsa-miR-137 | MGST1 | -0.08 | 0.93052 | 1.98 | 0.01957 | miRanda | -0.19 | 0.01016 | NA | |
85 | hsa-miR-137 | MIPOL1 | -0.08 | 0.93052 | 0.93 | 0.01754 | miRanda | -0.12 | 0.00017 | NA | |
86 | hsa-miR-137 | MMP7 | -0.08 | 0.93052 | 1.11 | 0.44682 | miRanda | -0.29 | 0.02065 | NA | |
87 | hsa-miR-137 | MORC4 | -0.08 | 0.93052 | 0.74 | 0.01543 | PITA; miRanda | -0.11 | 2.0E-5 | NA | |
88 | hsa-miR-137 | MUC20 | -0.08 | 0.93052 | 0.85 | 0.28357 | miRanda; mirMAP | -0.15 | 0.03013 | NA | |
89 | hsa-miR-137 | MXRA5 | -0.08 | 0.93052 | 0.35 | 0.66986 | miRanda | -0.18 | 0.00934 | NA | |
90 | hsa-miR-137 | MYO3B | -0.08 | 0.93052 | -0.85 | 0.33468 | miRanda | -0.19 | 0.01149 | NA | |
91 | hsa-miR-137 | NEIL3 | -0.08 | 0.93052 | 0.75 | 0.19998 | miRanda | -0.15 | 0.00305 | NA | |
92 | hsa-miR-137 | NEK2 | -0.08 | 0.93052 | 1.77 | 0.01265 | miRanda | -0.16 | 0.00916 | NA | |
93 | hsa-miR-137 | OAS1 | -0.08 | 0.93052 | 0.23 | 0.68958 | miRanda | -0.12 | 0.01258 | NA | |
94 | hsa-miR-137 | OSMR | -0.08 | 0.93052 | 0.18 | 0.7299 | miRanda | -0.11 | 0.0146 | NA | |
95 | hsa-miR-137 | PARD3B | -0.08 | 0.93052 | 0.01 | 0.98353 | mirMAP | -0.12 | 0.04232 | NA | |
96 | hsa-miR-137 | PHGDH | -0.08 | 0.93052 | -0.28 | 0.65262 | miRanda | -0.2 | 0.00011 | NA | |
97 | hsa-miR-137 | PLBD1 | -0.08 | 0.93052 | 1.06 | 0.12792 | miRanda | -0.16 | 0.00539 | NA | |
98 | hsa-miR-137 | PLD1 | -0.08 | 0.93052 | 0.2 | 0.6783 | miRanda | -0.12 | 0.00439 | NA | |
99 | hsa-miR-137 | POSTN | -0.08 | 0.93052 | 0.55 | 0.53451 | miRanda | -0.17 | 0.02708 | NA | |
100 | hsa-miR-137 | PPIC | -0.08 | 0.93052 | 0.35 | 0.41467 | miRanda | -0.1 | 0.00419 | NA | |
101 | hsa-miR-137 | PRR11 | -0.08 | 0.93052 | 1.08 | 0.23953 | miRanda | -0.17 | 0.0344 | NA | |
102 | hsa-miR-137 | PRRG1 | -0.08 | 0.93052 | 0.81 | 0.04025 | miRanda | -0.11 | 0.00085 | NA | |
103 | hsa-miR-137 | PRSS16 | -0.08 | 0.93052 | 0.91 | 0.16328 | miRanda | -0.22 | 5.0E-5 | NA | |
104 | hsa-miR-137 | PTER | -0.08 | 0.93052 | 0.15 | 0.66494 | miRanda | -0.14 | 0 | NA | |
105 | hsa-miR-137 | PTGFRN | -0.08 | 0.93052 | 0.59 | 0.16374 | MirTarget; PITA; miRanda; miRNATAP | -0.13 | 0.00031 | NA | |
106 | hsa-miR-137 | PTGS2 | -0.08 | 0.93052 | 2.09 | 0.02703 | miRNAWalker2 validate; miRTarBase; MirTarget; miRanda | -0.18 | 0.02895 | 22406049 | miR 137 is frequently down regulated in glioblastoma and is a negative regulator of Cox 2; Using computational and expression analysis Cox-2 was identified as a candidate target of miR-137; Reporter assay with 3'UTR of Cox-2 cloned downstream of the luciferase gene showed reduced luciferase activity in the presence of miR-137 providing strong evidence that miR-137 was a direct regulator of Cox-2; Furthermore we observed that Cox-2 knockdown resulted in effects similar to those with miR-137 transfection in glioma cells |
107 | hsa-miR-137 | PTPN14 | -0.08 | 0.93052 | 0.52 | 0.29139 | miRNATAP | -0.11 | 0.00724 | NA | |
108 | hsa-miR-137 | RCC1 | -0.08 | 0.93052 | 0.08 | 0.8926 | MirTarget; miRanda | -0.2 | 5.0E-5 | NA | |
109 | hsa-miR-137 | RTP4 | -0.08 | 0.93052 | -0.08 | 0.87124 | miRanda | -0.1 | 0.01593 | NA | |
110 | hsa-miR-137 | S100A11 | -0.08 | 0.93052 | 0.67 | 0.26503 | miRanda | -0.11 | 0.03619 | NA | |
111 | hsa-miR-137 | SEL1L3 | -0.08 | 0.93052 | -0.47 | 0.31995 | miRanda | -0.24 | 0 | NA | |
112 | hsa-miR-137 | SERPINA3 | -0.08 | 0.93052 | -0.66 | 0.59748 | miRanda | -0.28 | 0.00835 | NA | |
113 | hsa-miR-137 | SH3RF2 | -0.08 | 0.93052 | 2.41 | 0.01711 | mirMAP | -0.31 | 0.00026 | NA | |
114 | hsa-miR-137 | SLC12A2 | -0.08 | 0.93052 | 0.15 | 0.76981 | MirTarget; PITA; miRanda; miRNATAP | -0.16 | 0.00033 | NA | |
115 | hsa-miR-137 | SLC1A5 | -0.08 | 0.93052 | 1.01 | 0.02718 | PITA; miRanda; miRNATAP | -0.14 | 0.00046 | NA | |
116 | hsa-miR-137 | SLC5A1 | -0.08 | 0.93052 | 1.6 | 0.11365 | miRanda | -0.3 | 0.00047 | NA | |
117 | hsa-miR-137 | SLC6A20 | -0.08 | 0.93052 | 1.71 | 0.1145 | mirMAP | -0.27 | 0.00371 | NA | |
118 | hsa-miR-137 | STRA6 | -0.08 | 0.93052 | 0.15 | 0.85847 | miRanda | -0.21 | 0.00228 | NA | |
119 | hsa-miR-137 | SYTL4 | -0.08 | 0.93052 | 0.4 | 0.37603 | miRanda | -0.15 | 0.00013 | NA | |
120 | hsa-miR-137 | TCEA3 | -0.08 | 0.93052 | 0.69 | 0.27073 | miRanda | -0.21 | 5.0E-5 | NA | |
121 | hsa-miR-137 | TCF7L2 | -0.08 | 0.93052 | 0.35 | 0.38095 | miRanda | -0.11 | 0.00168 | NA | |
122 | hsa-miR-137 | TFPI | -0.08 | 0.93052 | 0.61 | 0.2441 | miRanda | -0.11 | 0.01787 | NA | |
123 | hsa-miR-137 | TGFA | -0.08 | 0.93052 | 0.69 | 0.27654 | PITA; miRanda | -0.13 | 0.0212 | NA | |
124 | hsa-miR-137 | TMPRSS13 | -0.08 | 0.93052 | -0.88 | 0.24263 | miRanda | -0.18 | 0.00636 | NA | |
125 | hsa-miR-137 | TMPRSS4 | -0.08 | 0.93052 | 5.41 | 0.00024 | miRanda | -0.31 | 0.0161 | NA | |
126 | hsa-miR-137 | TRPA1 | -0.08 | 0.93052 | 0.83 | 0.39097 | miRanda | -0.28 | 0.00066 | NA | |
127 | hsa-miR-137 | UBQLNL | -0.08 | 0.93052 | -0.49 | 0.3764 | miRanda | -0.1 | 0.03027 | NA | |
128 | hsa-miR-137 | WDR72 | -0.08 | 0.93052 | 2.41 | 0.09538 | miRanda | -0.32 | 0.00971 | NA | |
129 | hsa-miR-137 | ZNF217 | -0.08 | 0.93052 | -0.36 | 0.36411 | MirTarget; PITA; miRanda; miRNATAP | -0.12 | 0.00056 | NA |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | APICAL PART OF CELL | 12 | 361 | 9.598e-07 | 0.0005605 |
2 | APICAL PLASMA MEMBRANE | 10 | 292 | 6.231e-06 | 0.001819 |
Num | Pathway | Pathview | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|---|
1 | hsa00564_Glycerophospholipid_metabolism | 3 | 80 | 0.01053 | 0.5884 | |
2 | hsa04974_Protein_digestion_and_absorption | 3 | 81 | 0.01089 | 0.5884 | |
3 | hsa04970_Salivary_secretion | 3 | 89 | 0.01403 | 0.5884 | |
4 | hsa00260_Glycine._serine_and_threonine_metabolism | 2 | 32 | 0.01405 | 0.5884 | |
5 | hsa00565_Ether_lipid_metabolism | 2 | 36 | 0.01759 | 0.5884 | |
6 | hsa04972_Pancreatic_secretion | 3 | 101 | 0.01961 | 0.5884 | |
7 | hsa04973_Carbohydrate_digestion_and_absorption | 2 | 44 | 0.02565 | 0.6596 | |
8 | hsa04151_PI3K_AKT_signaling_pathway | 5 | 351 | 0.04906 | 0.9857 | |
9 | hsa04310_Wnt_signaling_pathway | 3 | 151 | 0.05419 | 0.9857 | |
10 | hsa04610_Complement_and_coagulation_cascades | 2 | 69 | 0.05811 | 0.9857 | |
11 | hsa04976_Bile_secretion | 2 | 71 | 0.06111 | 0.9857 | |
12 | hsa04971_Gastric_acid_secretion | 2 | 74 | 0.06571 | 0.9857 | |
13 | hsa04070_Phosphatidylinositol_signaling_system | 2 | 78 | 0.07202 | 0.9972 | |
14 | hsa04512_ECM.receptor_interaction | 2 | 85 | 0.0835 | 1 | |
15 | hsa04012_ErbB_signaling_pathway | 2 | 87 | 0.08688 | 1 | |
16 | hsa04912_GnRH_signaling_pathway | 2 | 101 | 0.1116 | 1 | |
17 | hsa04110_Cell_cycle | 2 | 128 | 0.1633 | 1 | |
18 | hsa04390_Hippo_signaling_pathway | 2 | 154 | 0.2163 | 1 | |
19 | hsa04020_Calcium_signaling_pathway | 2 | 177 | 0.2642 | 1 | |
20 | hsa04510_Focal_adhesion | 2 | 200 | 0.3123 | 1 | |
21 | hsa04144_Endocytosis | 2 | 203 | 0.3185 | 1 | |
22 | hsa04014_Ras_signaling_pathway | 2 | 236 | 0.386 | 1 |
Num | lncRNA | miRNAs | miRNAs count | Gene | Sponge regulatory network | lncRNA log2FC | lncRNA pvalue | Gene log2FC | Gene pvalue | lncRNA-gene Pearson correlation |
---|---|---|---|---|---|---|---|---|---|---|
1 | RFPL1S | hsa-let-7a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-192-3p;hsa-miR-194-5p;hsa-miR-200a-3p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-27b-3p;hsa-miR-32-5p;hsa-miR-429 | 13 | KLF12 | Sponge network | -0.457 | 0.43621 | -1.061 | 0.01138 | 0.523 |
2 | HCG11 | hsa-let-7a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-192-3p;hsa-miR-194-5p;hsa-miR-19b-1-5p;hsa-miR-200a-3p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-27b-3p;hsa-miR-362-3p | 13 | KLF12 | Sponge network | -0.31 | 0.48859 | -1.061 | 0.01138 | 0.472 |
3 | CECR7 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-192-3p;hsa-miR-194-5p;hsa-miR-19b-1-5p;hsa-miR-200a-3p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-27b-3p;hsa-miR-30b-5p;hsa-miR-30d-5p;hsa-miR-429 | 13 | KLF12 | Sponge network | -0.527 | 0.47624 | -1.061 | 0.01138 | 0.406 |