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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-532-3p ACHE 0.03 0.96292 0.34 0.36972 miRNATAP -0.31 0.02272 NA
2 hsa-miR-532-3p ACTN1 0.03 0.96292 0.19 0.85494 miRNATAP -0.28 0 NA
3 hsa-miR-532-3p ADAMTS2 0.03 0.96292 -0.17 0.66831 mirMAP -0.35 0.00281 NA
4 hsa-miR-532-3p AEBP2 0.03 0.96292 -0.07 0.92553 PITA; miRNATAP -0.13 0.0011 NA
5 hsa-miR-532-3p ATP11B 0.03 0.96292 -0.01 0.99071 MirTarget -0.18 0.0014 NA
6 hsa-miR-532-3p BASP1 0.03 0.96292 0.64 0.35468 PITA -0.49 0.0001 NA
7 hsa-miR-532-3p BCL2L2 0.03 0.96292 -0.01 0.99028 MirTarget; miRNATAP -0.11 0.01255 NA
8 hsa-miR-532-3p BCL9L 0.03 0.96292 0.01 0.99002 mirMAP -0.16 0.00089 NA
9 hsa-miR-532-3p BDKRB2 0.03 0.96292 -0.12 0.85875 mirMAP -0.31 0.00012 NA
10 hsa-miR-532-3p BTK 0.03 0.96292 0.02 0.9601 miRNATAP -0.35 0.0001 NA
11 hsa-miR-532-3p C6orf132 0.03 0.96292 0.23 0.66918 miRNATAP -0.2 0.01001 NA
12 hsa-miR-532-3p CADM3 0.03 0.96292 0.51 0.2616 MirTarget -0.32 0.0407 NA
13 hsa-miR-532-3p CCDC68 0.03 0.96292 0.11 0.78962 MirTarget -0.33 0.01125 NA
14 hsa-miR-532-3p CD44 0.03 0.96292 -0.15 0.89705 miRNATAP -0.32 1.0E-5 NA
15 hsa-miR-532-3p CHST2 0.03 0.96292 0.06 0.90196 MirTarget -0.32 0.00515 NA
16 hsa-miR-532-3p COL1A1 0.03 0.96292 -0.46 0.71115 PITA; miRNATAP -0.26 0.00868 NA
17 hsa-miR-532-3p COL4A4 0.03 0.96292 0.48 0.18628 miRNATAP -0.36 0.00835 NA
18 hsa-miR-532-3p COL6A6 0.03 0.96292 0.07 0.88599 MirTarget -0.6 2.0E-5 NA
19 hsa-miR-532-3p CRISPLD2 0.03 0.96292 0.08 0.89316 miRNATAP -0.23 0.00724 NA
20 hsa-miR-532-3p CSF1 0.03 0.96292 0.22 0.69417 MirTarget; PITA -0.32 5.0E-5 NA
21 hsa-miR-532-3p CYP26B1 0.03 0.96292 -0.05 0.90069 MirTarget; miRNATAP -0.32 0.00205 NA
22 hsa-miR-532-3p DAB2 0.03 0.96292 -0.13 0.81546 PITA -0.22 0.00269 NA
23 hsa-miR-532-3p DAB2IP 0.03 0.96292 0.02 0.97637 mirMAP -0.15 0.00378 NA
24 hsa-miR-532-3p DOCK2 0.03 0.96292 0.1 0.8233 miRNATAP -0.31 0.00079 NA
25 hsa-miR-532-3p DST 0.03 0.96292 0.35 0.72945 mirMAP -0.55 0 NA
26 hsa-miR-532-3p DUSP7 0.03 0.96292 -0.2 0.81463 mirMAP -0.36 2.0E-5 NA
27 hsa-miR-532-3p EFNB1 0.03 0.96292 0.08 0.93293 PITA; miRNATAP -0.31 0.00018 NA
28 hsa-miR-532-3p EHBP1 0.03 0.96292 0.05 0.94981 PITA -0.21 0 NA
29 hsa-miR-532-3p ELOVL3 0.03 0.96292 0.45 0.18648 miRNATAP -0.25 0.04718 NA
30 hsa-miR-532-3p ENAH 0.03 0.96292 0.04 0.96386 miRNATAP -0.12 0.02758 NA
31 hsa-miR-532-3p ETS1 0.03 0.96292 0.16 0.83815 MirTarget; PITA; miRNATAP -0.16 0.01662 NA
32 hsa-miR-532-3p FAM49A 0.03 0.96292 -0.01 0.98041 MirTarget; miRNATAP -0.27 0.00306 NA
33 hsa-miR-532-3p FGF1 0.03 0.96292 0.44 0.17318 miRNATAP -0.39 0.00053 NA
34 hsa-miR-532-3p FGF11 0.03 0.96292 -0.1 0.8531 mirMAP -0.39 0.00098 NA
35 hsa-miR-194-5p FGFR3 0.08 0.9409 -0.04 0.96357 miRNATAP -0.21 0.00062 NA
36 hsa-miR-99b-5p FGFR3 0.25 0.88903 -0.04 0.96357 MirTarget; miRNATAP -0.82 0 22969861 miR-99b was downregulated and FGFR3 was upregulated in lung cancer patients; We demonstrated that the overexpression of miR-99b induced a reduction in FGFR3 expression and confirmed the target specificity between miR-99b and the FGFR3 3'-untranslated region by luciferase reporter assay; Taken together these results suggest that miR-99b may be a tumor suppressor through the downregulation of FGFR3 miR-99b may be a potent tumor suppressor and may be a potential therapeutic tool for patients with lung cancer
37 hsa-miR-532-3p FLYWCH1 0.03 0.96292 0.06 0.93496 mirMAP -0.11 0.01486 NA
38 hsa-miR-532-3p FOXD3 0.03 0.96292 0.05 0.91708 miRNATAP -0.33 0.04056 NA
39 hsa-miR-532-3p FOXK1 0.03 0.96292 -0.04 0.95497 mirMAP -0.12 0.02695 NA
40 hsa-miR-532-3p FRMD4A 0.03 0.96292 0.1 0.84221 MirTarget -0.18 0.00144 NA
41 hsa-miR-532-3p GABRA3 0.03 0.96292 -0.27 0.66373 MirTarget -0.41 0.046 NA
42 hsa-miR-532-3p GDF6 0.03 0.96292 0.16 0.78605 PITA; miRNATAP -0.6 0.00112 NA
43 hsa-miR-532-3p GFRA1 0.03 0.96292 -0.09 0.8253 miRNATAP -0.38 0.0097 NA
44 hsa-miR-532-3p GPR68 0.03 0.96292 -0.57 0.30857 mirMAP -0.64 0 NA
45 hsa-miR-532-3p GPRC5A 0.03 0.96292 0.15 0.86152 MirTarget -0.37 0.00213 NA
46 hsa-miR-532-3p GRIP2 0.03 0.96292 0.14 0.73686 MirTarget -0.38 0.00094 NA
47 hsa-miR-532-3p HAS3 0.03 0.96292 -0.09 0.90632 PITA; miRNATAP -0.51 0.00083 NA
48 hsa-miR-532-3p HDAC7 0.03 0.96292 0.08 0.92352 miRNATAP -0.11 0.00222 NA
49 hsa-miR-532-3p HES2 0.03 0.96292 -0.78 0.31028 mirMAP -0.62 0.00014 NA
50 hsa-miR-532-3p IER2 0.03 0.96292 -0.13 0.89192 miRNATAP -0.13 0.01685 NA
51 hsa-miR-532-3p IFFO2 0.03 0.96292 -0.27 0.73741 MirTarget -0.32 0.00075 NA
52 hsa-miR-532-3p IGFBP4 0.03 0.96292 -0.32 0.76514 miRNATAP -0.19 0.00836 NA
53 hsa-miR-532-3p IL19 0.03 0.96292 -0.08 0.87338 MirTarget; miRNATAP -0.44 0.01047 NA
54 hsa-miR-532-3p KIAA1644 0.03 0.96292 0.32 0.38311 MirTarget -0.45 0.00036 NA
55 hsa-miR-532-3p LIMK2 0.03 0.96292 0.09 0.92104 MirTarget; miRNATAP -0.2 0 NA
56 hsa-miR-532-3p LMNA 0.03 0.96292 -0.06 0.95805 miRNATAP -0.14 0.0023 NA
57 hsa-miR-532-3p LPCAT3 0.03 0.96292 -0.04 0.95949 miRNATAP -0.1 0.0105 NA
58 hsa-miR-532-3p MAFK 0.03 0.96292 -0.25 0.73852 MirTarget -0.15 0.00722 NA
59 hsa-miR-532-3p MEF2D 0.03 0.96292 0.08 0.92121 mirMAP -0.12 0.00039 NA
60 hsa-miR-532-3p MET 0.03 0.96292 0.27 0.74718 PITA -0.19 0.01423 NA
61 hsa-miR-532-3p MMP14 0.03 0.96292 -0.03 0.98067 miRNATAP -0.25 2.0E-5 NA
62 hsa-miR-532-3p MRVI1 0.03 0.96292 0 0.99206 MirTarget -0.19 0.02905 NA
63 hsa-miR-532-3p MSRB3 0.03 0.96292 0.17 0.72624 MirTarget; PITA; miRNATAP -0.37 0.00035 NA
64 hsa-miR-532-3p MYOM3 0.03 0.96292 -0.68 0.05571 MirTarget -0.43 0.00109 NA
65 hsa-miR-532-3p NEFM 0.03 0.96292 -1 0.07354 miRNATAP -0.55 0.00696 NA
66 hsa-miR-532-3p NFASC 0.03 0.96292 -0.48 0.29576 MirTarget; miRNATAP -0.44 0.00024 NA
67 hsa-miR-532-3p NPTX1 0.03 0.96292 0.29 0.54636 PITA; miRNATAP -0.33 0.0368 NA
68 hsa-miR-532-3p OLFML2A 0.03 0.96292 -0.04 0.95135 mirMAP -0.37 0.00018 NA
69 hsa-miR-532-3p OSCAR 0.03 0.96292 -0.04 0.89921 MirTarget -0.19 0.01053 NA
70 hsa-miR-532-3p P2RX6 0.03 0.96292 0.18 0.66047 mirMAP -0.43 0.00017 NA
71 hsa-miR-532-3p PACS1 0.03 0.96292 0.08 0.92439 miRNATAP -0.11 0.00083 NA
72 hsa-miR-532-3p PAPPA 0.03 0.96292 0.21 0.55328 PITA; miRNATAP -0.5 9.0E-5 NA
73 hsa-miR-532-3p PDE4D 0.03 0.96292 0.17 0.77377 PITA; miRNATAP -0.22 0.02087 NA
74 hsa-miR-532-3p PDE7B 0.03 0.96292 -0.16 0.54894 miRNATAP -0.26 0.00398 NA
75 hsa-miR-532-3p PDPN 0.03 0.96292 0.61 0.34229 miRNATAP -0.54 5.0E-5 NA
76 hsa-miR-532-3p PFKM 0.03 0.96292 0 0.99745 miRNATAP -0.19 0.00198 NA
77 hsa-miR-532-3p PID1 0.03 0.96292 0.01 0.98399 MirTarget -0.47 9.0E-5 NA
78 hsa-miR-532-3p PIM1 0.03 0.96292 0.07 0.93224 miRNATAP -0.33 0 NA
79 hsa-miR-532-3p PKP1 0.03 0.96292 -0.49 0.66613 mirMAP -1.04 3.0E-5 NA
80 hsa-miR-532-3p PLA2G2F 0.03 0.96292 -0.53 0.37347 mirMAP -0.5 0.0191 NA
81 hsa-miR-532-3p PLCH2 0.03 0.96292 -0.23 0.74997 mirMAP -0.75 0 NA
82 hsa-miR-532-3p PLXDC1 0.03 0.96292 -0.07 0.87202 mirMAP -0.22 0.00275 NA
83 hsa-miR-532-3p PMEPA1 0.03 0.96292 -0.02 0.9833 mirMAP -0.44 0 NA
84 hsa-miR-532-3p POU2F2 0.03 0.96292 0.11 0.67688 mirMAP -0.2 0.00981 NA
85 hsa-miR-532-3p PPM1F 0.03 0.96292 -0.24 0.7276 MirTarget; mirMAP -0.12 0.01133 NA
86 hsa-miR-532-3p PPP1R16B 0.03 0.96292 0.28 0.48044 miRNATAP -0.17 0.04201 NA
87 hsa-miR-532-3p PROS1 0.03 0.96292 -0.46 0.40375 MirTarget -0.23 0.03121 NA
88 hsa-miR-532-3p PTGIS 0.03 0.96292 0.17 0.65484 miRNATAP -0.32 0.02444 NA
89 hsa-miR-532-3p PTPRK 0.03 0.96292 0.13 0.87264 PITA; miRNATAP -0.13 0.01068 NA
90 hsa-miR-532-3p RASIP1 0.03 0.96292 -0.46 0.53219 PITA -0.28 0.00353 NA
91 hsa-miR-532-3p RCSD1 0.03 0.96292 0.07 0.85678 miRNATAP -0.21 0.01151 NA
92 hsa-miR-532-3p RIMKLB 0.03 0.96292 0.21 0.74798 MirTarget -0.24 0.00089 NA
93 hsa-miR-532-3p RIMS3 0.03 0.96292 -0.1 0.79566 mirMAP -0.42 3.0E-5 NA
94 hsa-miR-532-3p RNF145 0.03 0.96292 0.06 0.94315 MirTarget -0.11 0.02374 NA
95 hsa-miR-532-3p RNF165 0.03 0.96292 0.26 0.46245 mirMAP -0.34 0.00534 NA
96 hsa-miR-532-3p RPS6KA2 0.03 0.96292 0.21 0.72583 MirTarget; mirMAP -0.17 0.04214 NA
97 hsa-miR-532-3p S1PR5 0.03 0.96292 -0.12 0.85341 miRNATAP -0.79 0 NA
98 hsa-miR-532-3p SAMD4A 0.03 0.96292 0.35 0.45428 MirTarget -0.3 0.00034 NA
99 hsa-miR-532-3p SCN2B 0.03 0.96292 0.5 0.40354 mirMAP -0.29 0.03048 NA
100 hsa-miR-532-3p SFN 0.03 0.96292 -0.17 0.89833 miRNATAP -0.43 0.00047 NA
101 hsa-miR-532-3p SH2D5 0.03 0.96292 0.32 0.45694 mirMAP -0.35 0.03082 NA
102 hsa-miR-532-3p SH3PXD2A 0.03 0.96292 0.07 0.93884 MirTarget -0.13 0.00658 NA
103 hsa-miR-532-3p SLC6A17 0.03 0.96292 0.15 0.76037 mirMAP -0.47 0.0085 NA
104 hsa-miR-532-3p SLC7A5 0.03 0.96292 -0.23 0.81516 mirMAP -0.28 0.01172 NA
105 hsa-miR-532-3p SNX24 0.03 0.96292 -0.02 0.96035 MirTarget -0.14 0.0015 NA
106 hsa-miR-532-3p SNX33 0.03 0.96292 0.12 0.86733 mirMAP -0.21 2.0E-5 NA
107 hsa-miR-532-3p SPARC 0.03 0.96292 -0.27 0.81142 miRNATAP -0.2 0.01751 NA
108 hsa-miR-532-3p SPN 0.03 0.96292 0.13 0.74573 mirMAP -0.26 0.00366 NA
109 hsa-miR-532-3p ST3GAL1 0.03 0.96292 -0.06 0.93411 mirMAP -0.24 0.0016 NA
110 hsa-miR-532-3p ST6GALNAC2 0.03 0.96292 0.23 0.75366 MirTarget -0.21 0.00786 NA
111 hsa-miR-532-3p STAT1 0.03 0.96292 0.17 0.87548 MirTarget -0.24 0.00078 NA
112 hsa-miR-532-3p STX1B 0.03 0.96292 0.45 0.09432 mirMAP -0.24 0.01175 NA
113 hsa-miR-532-3p SYDE1 0.03 0.96292 0.31 0.53746 miRNATAP -0.58 0 NA
114 hsa-miR-532-3p SYNM 0.03 0.96292 -0.08 0.88094 miRNATAP -0.19 0.01883 NA
115 hsa-miR-532-3p TBC1D2B 0.03 0.96292 0.07 0.92344 MirTarget -0.16 5.0E-5 NA
116 hsa-miR-532-3p TEAD3 0.03 0.96292 0.12 0.88229 miRNATAP -0.1 0.00523 NA
117 hsa-miR-532-3p TREM2 0.03 0.96292 -0.23 0.62372 miRNATAP -0.26 0.03219 NA
118 hsa-miR-532-3p TUB 0.03 0.96292 0.14 0.69706 mirMAP -0.32 0.01306 NA
119 hsa-miR-532-3p UST 0.03 0.96292 0.08 0.86708 miRNATAP -0.25 0.01469 NA
120 hsa-miR-532-3p WNT9A 0.03 0.96292 -0.49 0.12327 mirMAP -0.27 0.01919 NA
121 hsa-miR-532-3p ZNF462 0.03 0.96292 0.37 0.41984 PITA -0.32 0.00935 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 23 1151 3.051e-07 0.0001782
2 EXTRACELLULAR MATRIX 13 426 1.72e-06 0.0003348
3 PROTEINACEOUS EXTRACELLULAR MATRIX 12 356 1.582e-06 0.0003348
4 ANCHORING JUNCTION 12 489 3.852e-05 0.005624

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 ECM_receptor_interaction_hsa04512 4 82 0.001503 0.04184
2 Regulation_of_actin_cytoskeleton_hsa04810 6 208 0.001609 0.04184
3 Ras_signaling_pathway_hsa04014 6 232 0.002781 0.0482
4 PI3K_Akt_signaling_pathway_hsa04151 7 352 0.005374 0.06986
5 Focal_adhesion_hsa04510 5 199 0.007027 0.07308
6 MAPK_signaling_pathway_hsa04010 6 295 0.008807 0.07633
7 Hippo_signaling_pathway_hsa04390 4 154 0.01394 0.1036
8 TNF_signaling_pathway_hsa04668 3 108 0.02728 0.1773
9 Rap1_signaling_pathway_hsa04015 4 206 0.03566 0.206
10 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.05681 0.2785
11 mTOR_signaling_pathway_hsa04150 3 151 0.06261 0.2785
12 Adherens_junction_hsa04520 2 72 0.06956 0.2785
13 Jak_STAT_signaling_pathway_hsa04630 3 162 0.07392 0.2785
14 cGMP_PKG_signaling_pathway_hsa04022 3 163 0.07499 0.2785
15 Neuroactive_ligand_receptor_interaction_hsa04080 4 278 0.08651 0.2999
16 Sphingolipid_signaling_pathway_hsa04071 2 118 0.158 0.4902
17 Apoptosis_hsa04210 2 138 0.2009 0.5468
18 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.2031 0.5468
19 Cytokine_cytokine_receptor_interaction_hsa04060 3 270 0.2208 0.5468
20 Calcium_signaling_pathway_hsa04020 2 182 0.2983 0.705
21 Endocytosis_hsa04144 2 244 0.4315 0.8724

Quest ID: 3d93d990f70327c1398fd9e4c9bde3a0