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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-145-5p CNDP2 -2.63 0 0.62 0 MirTarget -0.11 0 NA
2 hsa-miR-361-5p CNDP2 -0.1 0.09543 0.62 0 miRanda -0.17 1.0E-5 NA
NumGOOverlapSizeP ValueAdj. P Value
1 SMALL MOLECULE METABOLIC PROCESS 26 1767 1.244e-09 2.393e-06
2 ETHANOL METABOLIC PROCESS 5 14 1.543e-09 2.393e-06
3 PRIMARY ALCOHOL METABOLIC PROCESS 7 47 5.783e-10 2.393e-06
4 CARBOXYLIC ACID BIOSYNTHETIC PROCESS 9 270 1.054e-06 0.0008176
5 ORGANIC ACID BIOSYNTHETIC PROCESS 9 270 1.054e-06 0.0008176
6 CELLULAR ALDEHYDE METABOLIC PROCESS 6 84 9.238e-07 0.0008176
7 ORGANIC ACID METABOLIC PROCESS 15 953 3.469e-06 0.002306
8 NEURONAL ACTION POTENTIAL 4 28 4.081e-06 0.002374
9 OXIDATION REDUCTION PROCESS 14 898 8.588e-06 0.00444
10 CATION TRANSPORT 13 796 1.149e-05 0.005348
11 ORGANONITROGEN COMPOUND METABOLIC PROCESS 20 1796 1.274e-05 0.005391
12 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 4 39 1.587e-05 0.005783
13 ION TRANSMEMBRANE TRANSPORT 13 822 1.616e-05 0.005783
14 ORGANIC HYDROXY COMPOUND METABOLIC PROCESS 10 482 1.748e-05 0.00581
15 TRANSMEMBRANE TRANSPORT 15 1098 1.89e-05 0.005863
16 CELLULAR AMINO ACID BIOSYNTHETIC PROCESS 5 93 3.15e-05 0.008622
17 POSITIVE REGULATION OF TELOMERE CAPPING 3 16 3.081e-05 0.008622
NumGOOverlapSizeP ValueAdj. P Value
1 OXIDOREDUCTASE ACTIVITY ACTING ON THE ALDEHYDE OR OXO GROUP OF DONORS NAD OR NADP AS ACCEPTOR 5 36 2.717e-07 0.0001343
2 OXIDOREDUCTASE ACTIVITY ACTING ON THE CH OH GROUP OF DONORS NAD OR NADP AS ACCEPTOR 7 113 2.892e-07 0.0001343
3 ALDEHYDE DEHYDROGENASE NAD ACTIVITY 4 19 7.935e-07 0.0001531
4 VOLTAGE GATED SODIUM CHANNEL ACTIVITY 4 20 9.889e-07 0.0001531
5 OXIDOREDUCTASE ACTIVITY ACTING ON CH OH GROUP OF DONORS 7 134 9.207e-07 0.0001531
6 OXIDOREDUCTASE ACTIVITY ACTING ON THE ALDEHYDE OR OXO GROUP OF DONORS 5 46 9.583e-07 0.0001531
7 EXOPEPTIDASE ACTIVITY 6 106 3.622e-06 0.0004808
8 CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 12 622 4.906e-06 0.0005697
9 SODIUM CHANNEL ACTIVITY 4 37 1.282e-05 0.001323
10 AMINOPEPTIDASE ACTIVITY 4 43 2.353e-05 0.00212
11 METALLOAMINOPEPTIDASE ACTIVITY 3 15 2.51e-05 0.00212
12 NAD BINDING 4 53 5.421e-05 0.004197
13 ACTIVE TRANSMEMBRANE TRANSPORTER ACTIVITY 8 356 7.384e-05 0.004346
14 RIBONUCLEOTIDE BINDING 19 1860 7.271e-05 0.004346
15 LIGASE ACTIVITY FORMING CARBON NITROGEN BONDS 4 56 6.74e-05 0.004346
16 COFACTOR BINDING 7 263 7.486e-05 0.004346
17 METALLOPEPTIDASE ACTIVITY 6 188 9.332e-05 0.005099
18 TRANSMEMBRANE TRANSPORTER ACTIVITY 13 997 0.0001174 0.00606
NumGOOverlapSizeP ValueAdj. P Value
1 VOLTAGE GATED SODIUM CHANNEL COMPLEX 4 14 2.08e-07 0.0001215
2 SODIUM CHANNEL COMPLEX 4 17 4.901e-07 0.0001431
3 INTRINSIC COMPONENT OF PLASMA MEMBRANE 18 1649 5.003e-05 0.009739

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa00010_Glycolysis_._Gluconeogenesis 7 65 6.053e-09 1.05e-06
2 hsa00350_Tyrosine_metabolism 6 41 1.167e-08 1.05e-06
3 hsa00980_Metabolism_of_xenobiotics_by_cytochrome_P450 6 71 3.388e-07 1.801e-05
4 hsa00982_Drug_metabolism_._cytochrome_P450 6 73 4.002e-07 1.801e-05
5 hsa00830_Retinol_metabolism 5 64 5.047e-06 0.0001817
6 hsa00071_Fatty_acid_metabolism 4 43 2.353e-05 0.000706
7 hsa00340_Histidine_metabolism 3 29 0.0001938 0.004984
8 hsa00360_Phenylalanine_metabolism 2 17 0.001966 0.03754
9 hsa04614_Renin.angiotensin_system 2 17 0.001966 0.03754
10 hsa04910_Insulin_signaling_pathway 4 138 0.002085 0.03754
11 hsa00020_Citrate_cycle_.TCA_cycle. 2 30 0.006086 0.08877
12 hsa00250_Alanine._aspartate_and_glutamate_metabolism 2 32 0.006904 0.08877
13 hsa00260_Glycine._serine_and_threonine_metabolism 2 32 0.006904 0.08877
14 hsa00640_Propanoate_metabolism 2 32 0.006904 0.08877
15 hsa00620_Pyruvate_metabolism 2 40 0.01064 0.1277
16 hsa04960_Aldosterone.regulated_sodium_reabsorption 2 42 0.01169 0.1315
17 hsa04514_Cell_adhesion_molecules_.CAMs. 3 136 0.01615 0.171
18 hsa04150_mTOR_signaling_pathway 2 52 0.01755 0.1755
19 hsa04920_Adipocytokine_signaling_pathway 2 68 0.02898 0.2484
20 hsa04730_Long.term_depression 2 70 0.03057 0.2501
21 hsa04974_Protein_digestion_and_absorption 2 81 0.0399 0.2993
22 hsa04510_Focal_adhesion 3 200 0.0434 0.3089
23 hsa04914_Progesterone.mediated_oocyte_maturation 2 87 0.0454 0.3089
24 hsa04640_Hematopoietic_cell_lineage 2 88 0.04634 0.3089
25 hsa04151_PI3K_AKT_signaling_pathway 4 351 0.04836 0.3109
26 hsa04810_Regulation_of_actin_cytoskeleton 3 214 0.05123 0.318
27 hsa04014_Ras_signaling_pathway 3 236 0.06481 0.3822
28 hsa04114_Oocyte_meiosis 2 114 0.07313 0.3989
29 hsa04360_Axon_guidance 2 130 0.09154 0.4656

Quest ID: 3ea0eed62024970d616da1a9a2638f05