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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-28-5p APC2 -0.43 0 1.72 0 mirMAP -0.3 0.00527 NA
2 hsa-let-7g-3p AXIN2 -1.14 0 0.11 0.75298 MirTarget -0.33 0.01126 NA
3 hsa-miR-15b-5p AXIN2 0.23 0.08248 0.11 0.75298 miRTarBase; MirTarget; miRNATAP -0.45 0.00081 NA
4 hsa-miR-16-2-3p AXIN2 -0.03 0.80516 0.11 0.75298 mirMAP -0.64 0 NA
5 hsa-miR-16-5p AXIN2 -0.4 0.0001 0.11 0.75298 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.49 0.00421 NA
6 hsa-miR-195-3p AXIN2 -1.09 0 0.11 0.75298 mirMAP -0.31 0.00083 NA
7 hsa-miR-26b-3p AXIN2 -1.26 0 0.11 0.75298 MirTarget -0.59 3.0E-5 NA
8 hsa-miR-326 AXIN2 -1.88 0 0.11 0.75298 miRanda -0.36 2.0E-5 NA
9 hsa-miR-338-5p AXIN2 -0.22 0.25239 0.11 0.75298 miRNATAP -0.34 0.00017 NA
10 hsa-miR-616-3p AXIN2 -0.7 2.0E-5 0.11 0.75298 MirTarget -0.42 8.0E-5 NA
11 hsa-miR-30e-3p CACYBP -1.21 0 0.95 0 MirTarget -0.35 0 NA
12 hsa-miR-15b-3p CAMK2A 0.24 0.09977 -0.33 0.35691 mirMAP -0.44 0.00022 NA
13 hsa-miR-21-3p CAMK2A -0.48 0.003 -0.33 0.35691 MirTarget -0.43 5.0E-5 NA
14 hsa-miR-25-3p CAMK2A 0.63 0 -0.33 0.35691 MirTarget -0.35 0.03714 NA
15 hsa-miR-7-1-3p CAMK2A -0.57 2.0E-5 -0.33 0.35691 MirTarget -0.36 0.00584 NA
16 hsa-miR-10b-3p CAMK2B 2.77 0 -3.79 0 mirMAP -0.45 0 NA
17 hsa-miR-10b-5p CAMK2B 2.87 0 -3.79 0 miRNATAP -0.42 0 NA
18 hsa-miR-140-3p CAMK2B 0.55 0 -3.79 0 mirMAP -1.81 0 NA
19 hsa-miR-186-5p CAMK2B -0.06 0.53529 -3.79 0 miRNAWalker2 validate; miRNATAP -0.97 5.0E-5 NA
20 hsa-miR-18a-5p CAMK2B 0.92 2.0E-5 -3.79 0 mirMAP -0.42 6.0E-5 NA
21 hsa-miR-34a-5p CAMK2B 1.04 0 -3.79 0 mirMAP -0.52 0.00135 NA
22 hsa-miR-362-3p CAMK2B 0.81 0 -3.79 0 miRanda -0.35 0.03414 NA
23 hsa-miR-362-5p CAMK2B 0.72 2.0E-5 -3.79 0 miRNATAP -0.35 0.01129 NA
24 hsa-miR-3913-5p CAMK2B 0.25 0.0628 -3.79 0 mirMAP -0.41 0.01943 NA
25 hsa-miR-589-3p CAMK2B 1.17 0 -3.79 0 MirTarget -0.78 0 NA
26 hsa-miR-106b-5p CCND1 0.65 0 -0.9 1.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.43 0 NA
27 hsa-miR-15b-5p CCND1 0.23 0.08248 -0.9 1.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.54 0 NA
28 hsa-miR-16-5p CCND1 -0.4 0.0001 -0.9 1.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.31 0.00178 23991964; 22922827; 18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL
29 hsa-miR-17-5p CCND1 0.7 2.0E-5 -0.9 1.0E-5 miRNAWalker2 validate; MirTarget; TargetScan; miRNATAP -0.34 0 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene
30 hsa-miR-186-5p CCND1 -0.06 0.53529 -0.9 1.0E-5 mirMAP -0.32 0.00286 NA
31 hsa-miR-19b-1-5p CCND1 -0.28 0.07831 -0.9 1.0E-5 miRNAWalker2 validate; miRTarBase -0.31 0 NA
32 hsa-miR-19b-3p CCND1 0.6 0.00017 -0.9 1.0E-5 miRNATAP -0.34 0 NA
33 hsa-miR-20a-5p CCND1 0.85 0 -0.9 1.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.33 0 NA
34 hsa-miR-340-5p CCND1 -0 0.9685 -0.9 1.0E-5 mirMAP -0.32 0.00013 NA
35 hsa-miR-425-5p CCND1 0.59 2.0E-5 -0.9 1.0E-5 miRNAWalker2 validate -0.39 0 NA
36 hsa-miR-92a-3p CCND1 0.21 0.13429 -0.9 1.0E-5 miRNAWalker2 validate -0.41 0 NA
37 hsa-miR-93-5p CCND1 1.4 0 -0.9 1.0E-5 miRNAWalker2 validate; MirTarget; miRNATAP -0.34 0 NA
38 hsa-miR-28-5p CCND2 -0.43 0 0.36 0.03656 miRanda -0.48 0 NA
39 hsa-miR-616-5p CCND2 0.15 0.40284 0.36 0.03656 mirMAP -0.32 0 NA
40 hsa-miR-22-3p CSNK2A1 -0.63 0 0.31 6.0E-5 miRNAWalker2 validate -0.31 0 NA
41 hsa-miR-616-5p CTBP2 0.15 0.40284 -0.39 0.02251 mirMAP -0.31 0 NA
42 hsa-miR-618 CTBP2 0.14 0.51715 -0.39 0.02251 MirTarget; PITA -0.33 0 NA
43 hsa-miR-21-5p DAAM1 1.51 0 -0.82 3.0E-5 miRNAWalker2 validate -0.58 0 NA
44 hsa-miR-92a-3p DAAM1 0.21 0.13429 -0.82 3.0E-5 miRNATAP -0.33 0 NA
45 hsa-miR-18a-5p DAAM2 0.92 2.0E-5 -0.83 6.0E-5 miRNAWalker2 validate -0.32 0 NA
46 hsa-miR-193a-3p DAAM2 -0.12 0.30939 -0.83 6.0E-5 miRanda -0.34 0.0001 NA
47 hsa-miR-339-5p DAAM2 0.28 0.03557 -0.83 6.0E-5 miRanda -0.41 0 NA
48 hsa-miR-29a-3p DKK1 -0.86 0 2.54 1.0E-5 miRNAWalker2 validate; miRTarBase -1.21 0 NA
49 hsa-miR-33a-3p DKK2 -0.68 1.0E-5 0.71 0.03131 mirMAP -0.4 0.00011 NA
50 hsa-miR-361-5p DKK2 0.23 0.00962 0.71 0.03131 miRanda -0.66 0.00028 NA
51 hsa-miR-374a-5p DKK2 0.02 0.86978 0.71 0.03131 mirMAP -0.77 0 NA
52 hsa-miR-374b-5p DKK2 -0.31 0.00301 0.71 0.03131 mirMAP -0.8 0 NA
53 hsa-miR-455-5p DKK2 -0.27 0.05813 0.71 0.03131 miRanda -0.45 6.0E-5 NA
54 hsa-miR-590-3p DKK2 -0.47 2.0E-5 0.71 0.03131 miRanda; mirMAP; miRNATAP -0.51 0.00043 NA
55 hsa-miR-590-5p DKK2 -0.1 0.31003 0.71 0.03131 miRanda -0.74 0 NA
56 hsa-miR-335-5p DKK4 -1.61 0 1.46 0.00691 miRNAWalker2 validate -0.64 0 NA
57 hsa-miR-192-5p FZD1 -0.5 0.00345 -0.99 0 miRNAWalker2 validate -0.46 0 NA
58 hsa-miR-107 FZD10 0.24 0.01708 1.19 0.00016 miRanda -0.69 1.0E-5 NA
59 hsa-miR-15a-5p FZD10 0.35 0.00077 1.19 0.00016 miRNATAP -0.44 0.00326 NA
60 hsa-miR-455-3p FZD10 -1.4 0 1.19 0.00016 PITA; miRNATAP -0.56 0 NA
61 hsa-miR-616-5p FZD2 0.15 0.40284 0.41 0.07557 MirTarget -0.34 0 NA
62 hsa-miR-107 FZD3 0.24 0.01708 -0.43 0.07605 MirTarget; miRanda -0.33 0.00541 NA
63 hsa-miR-30e-5p FZD3 -0.63 0 -0.43 0.07605 MirTarget -0.31 0.0078 NA
64 hsa-miR-361-5p FZD3 0.23 0.00962 -0.43 0.07605 miRanda; miRNATAP -0.46 0.0005 NA
65 hsa-miR-374a-5p FZD3 0.02 0.86978 -0.43 0.07605 mirMAP -0.52 2.0E-5 NA
66 hsa-miR-374b-5p FZD3 -0.31 0.00301 -0.43 0.07605 mirMAP -0.31 0.00624 NA
67 hsa-miR-106b-5p FZD4 0.65 0 -0.35 0.01097 miRNATAP -0.37 0 NA
68 hsa-miR-21-5p FZD4 1.51 0 -0.35 0.01097 mirMAP -0.32 0 NA
69 hsa-miR-324-3p FZD4 0.26 0.05061 -0.35 0.01097 miRNATAP -0.33 0 NA
70 hsa-miR-101-3p FZD6 -1.48 0 0.59 0.00374 miRNAWalker2 validate; MirTarget -0.31 1.0E-5 NA
71 hsa-miR-192-5p FZD7 -0.5 0.00345 -0.28 0.25656 miRNAWalker2 validate -0.59 0 NA
72 hsa-miR-192-5p FZD9 -0.5 0.00345 -0.24 0.50534 miRNATAP -0.31 0.0031 NA
73 hsa-miR-93-5p JUN 1.4 0 -1.6 0 miRNAWalker2 validate -0.35 0 NA
74 hsa-let-7a-3p LEF1 -0.57 0 2.66 0 miRNATAP -0.64 4.0E-5 NA
75 hsa-let-7b-3p LEF1 -1.22 0 2.66 0 miRNATAP -0.67 0 NA
76 hsa-miR-193b-3p LEF1 -0.17 0.27202 2.66 0 miRNAWalker2 validate -0.53 0 NA
77 hsa-miR-26a-5p LEF1 -0.96 0 2.66 0 miRNATAP -0.92 0 NA
78 hsa-miR-26b-5p LEF1 -1.11 0 2.66 0 miRNATAP -0.88 0 24785257 miR26b is downregulated in several cancers and tumors and miR26b directly targets the lymphoid enhancer factor 1 Lef13'UTR and inhibits endogenous Lef1 expression; We report that miR26b expression is associated with human colon cancer through the regulation of LEF1 expression in colon cancer cells; Analyses of multiple colon cancer cell lines revealed an inverse correlation between miR26b and LEF1 expression; Normal human colon cells express low levels of LEF1 and high levels of miR26b; however human colon cancer cells have decreased miR26b expression and increased LEF1 expression; We demonstrate that miR26b expression is a potent inhibitor of colon cancer cell proliferation and significantly decreases LEF1 expression; Analyses of human colon cancer databases also demonstrated a link between miR26b and LEF1 expression
79 hsa-miR-326 LEF1 -1.88 0 2.66 0 miRanda -0.39 0 NA
80 hsa-miR-33a-3p LEF1 -0.68 1.0E-5 2.66 0 miRNATAP -0.44 5.0E-5 NA
81 hsa-miR-455-5p LEF1 -0.27 0.05813 2.66 0 miRanda -0.35 0.00298 NA
82 hsa-miR-590-3p LEF1 -0.47 2.0E-5 2.66 0 PITA; miRanda; mirMAP -0.43 0.00459 NA
83 hsa-miR-7-1-3p LEF1 -0.57 2.0E-5 2.66 0 mirMAP -0.45 0.00035 NA
84 hsa-miR-221-3p MAPK10 1.12 0 -1.09 3.0E-5 miRNATAP -0.35 2.0E-5 NA
85 hsa-miR-590-5p MAPK10 -0.1 0.31003 -1.09 3.0E-5 PITA; miRanda; miRNATAP -0.37 0.00397 NA
86 hsa-miR-455-5p MMP7 -0.27 0.05813 -2.02 0.00038 miRanda -0.54 0.00528 NA
87 hsa-miR-423-5p MYC 0.7 0 -1.53 0 miRNAWalker2 validate -0.33 0.00485 NA
88 hsa-miR-455-5p NFATC1 -0.27 0.05813 -0.75 4.0E-5 miRanda -0.31 0 NA
89 hsa-miR-29a-5p NFATC2 -0.11 0.34962 -1.87 0 mirMAP; miRNATAP -0.58 6.0E-5 NA
90 hsa-miR-30d-5p NFATC2 0.72 0 -1.87 0 MirTarget; mirMAP -0.43 0.00143 NA
91 hsa-miR-24-3p NKD1 -0.26 0.0069 0.62 0.18603 miRNAWalker2 validate -0.72 0.00289 NA
92 hsa-miR-326 NKD1 -1.88 0 0.62 0.18603 miRanda -0.46 3.0E-5 NA
93 hsa-miR-330-5p NKD1 0.44 0.00533 0.62 0.18603 miRanda; miRNATAP -0.8 0 NA
94 hsa-miR-340-5p NKD1 -0 0.9685 0.62 0.18603 mirMAP -0.5 0.00902 NA
95 hsa-miR-501-5p NKD1 1.15 0 0.62 0.18603 mirMAP -0.34 0.00492 NA
96 hsa-let-7g-3p PLCB1 -1.14 0 1.21 0 miRNATAP -0.38 1.0E-5 NA
97 hsa-miR-125b-5p PLCB1 -1.36 0 1.21 0 miRNATAP -0.43 0 NA
98 hsa-miR-139-5p PLCB1 -2.11 0 1.21 0 miRanda -0.44 0 NA
99 hsa-miR-192-3p PLCB4 -0.64 0.00027 0.84 0.00057 miRNATAP -0.56 0 NA
100 hsa-miR-361-5p PLCB4 0.23 0.00962 0.84 0.00057 miRanda -0.32 0.01855 NA
101 hsa-miR-374a-5p PLCB4 0.02 0.86978 0.84 0.00057 mirMAP -0.4 0.00081 NA
102 hsa-miR-374b-5p PLCB4 -0.31 0.00301 0.84 0.00057 mirMAP -0.47 4.0E-5 NA
103 hsa-miR-590-3p PLCB4 -0.47 2.0E-5 0.84 0.00057 miRanda -0.41 0.00017 NA
104 hsa-miR-17-5p PRICKLE1 0.7 2.0E-5 -1.74 0 miRNAWalker2 validate -0.47 0 NA
105 hsa-miR-192-5p PRICKLE1 -0.5 0.00345 -1.74 0 miRNAWalker2 validate -0.65 0 NA
106 hsa-miR-361-5p PRICKLE1 0.23 0.00962 -1.74 0 miRanda -0.91 0 NA
107 hsa-miR-532-5p PRICKLE1 1.03 0 -1.74 0 miRNATAP -0.72 0 NA
108 hsa-miR-148a-3p PRICKLE2 -0.75 0 -1.36 0 MirTarget; miRNATAP -0.36 1.0E-5 NA
109 hsa-miR-148a-5p PRICKLE2 -0.77 0 -1.36 0 mirMAP -0.35 0 NA
110 hsa-miR-148b-3p PRICKLE2 0.27 0.00185 -1.36 0 MirTarget; miRNATAP -0.46 0.00102 NA
111 hsa-miR-589-5p PRICKLE2 1.19 0 -1.36 0 MirTarget; miRNATAP -0.54 0 NA
112 hsa-miR-194-5p PRKCB -0.29 0.09961 -1.62 0 miRNATAP -0.31 0 NA
113 hsa-miR-30d-5p PRKCB 0.72 0 -1.62 0 mirMAP -0.36 2.0E-5 NA
114 hsa-miR-361-5p PRKCB 0.23 0.00962 -1.62 0 MirTarget; miRanda; miRNATAP -0.42 0.00071 NA
115 hsa-miR-589-5p PRKCB 1.19 0 -1.62 0 mirMAP -0.55 0 NA
116 hsa-miR-664a-3p PRKCB 0.49 0.00073 -1.62 0 mirMAP -0.35 1.0E-5 NA
117 hsa-miR-140-3p PRKX 0.55 0 -0.24 0.24037 mirMAP -0.41 0.00049 NA
118 hsa-miR-148a-3p PRKX -0.75 0 -0.24 0.24037 MirTarget -0.59 0 NA
119 hsa-miR-23b-3p PRKX -0.53 0 -0.24 0.24037 mirMAP -0.34 0.00031 NA
120 hsa-miR-374a-3p PRKX -0.21 0.06235 -0.24 0.24037 mirMAP -0.33 0.0002 NA
121 hsa-miR-125a-5p RAC3 -0.91 0 0.67 0.00109 PITA -0.32 0 NA
122 hsa-miR-1301-3p SFRP1 1.12 0 -4.15 0 MirTarget -0.33 0.00114 NA
123 hsa-miR-16-1-3p SFRP1 0.39 0.00112 -4.15 0 MirTarget -0.72 0 NA
124 hsa-miR-192-3p SFRP1 -0.64 0.00027 -4.15 0 MirTarget -0.42 4.0E-5 NA
125 hsa-miR-501-5p SFRP1 1.15 0 -4.15 0 mirMAP -0.48 0 NA
126 hsa-miR-548b-3p SFRP1 -0.02 0.93082 -4.15 0 mirMAP -0.43 0 NA
127 hsa-miR-548j-5p SFRP1 0.25 0.17136 -4.15 0 MirTarget -0.45 1.0E-5 NA
128 hsa-miR-33a-3p SFRP2 -0.68 1.0E-5 0.47 0.28903 miRNATAP -0.32 0.02258 NA
129 hsa-miR-455-5p SFRP2 -0.27 0.05813 0.47 0.28903 miRanda -0.8 0 NA
130 hsa-miR-144-5p SFRP4 -1.55 0 2.13 0 MirTarget -0.35 0 NA
131 hsa-miR-26b-5p SFRP4 -1.11 0 2.13 0 miRNAWalker2 validate -0.77 0 NA
132 hsa-miR-3607-3p SFRP4 -2.16 0 2.13 0 MirTarget -0.34 1.0E-5 NA
133 hsa-miR-146b-5p SFRP5 0.42 0.04574 -6.77 0 miRanda -0.32 0.0319 NA
134 hsa-miR-590-3p SOX17 -0.47 2.0E-5 0.08 0.62256 miRanda; miRNATAP -0.31 1.0E-5 NA
135 hsa-miR-590-5p SOX17 -0.1 0.31003 0.08 0.62256 miRanda -0.4 0 NA
136 hsa-miR-24-3p TCF7 -0.26 0.0069 0.32 0.14929 miRNATAP -0.56 0 NA
137 hsa-miR-30e-3p TCF7 -1.21 0 0.32 0.14929 mirMAP -0.35 6.0E-5 NA
138 hsa-miR-331-3p TCF7 -0.28 0.03738 0.32 0.14929 MirTarget; miRNATAP -0.48 0 NA
139 hsa-miR-107 VANGL2 0.24 0.01708 -0.7 0.02922 miRanda -0.71 0 NA
140 hsa-miR-140-3p VANGL2 0.55 0 -0.7 0.02922 PITA; miRNATAP -0.75 5.0E-5 NA
141 hsa-miR-362-3p VANGL2 0.81 0 -0.7 0.02922 PITA; miRanda; miRNATAP -0.33 0.00342 NA
142 hsa-miR-378a-5p VANGL2 -1.59 0 -0.7 0.02922 MirTarget -0.38 0 NA
143 hsa-miR-589-5p VANGL2 1.19 0 -0.7 0.02922 mirMAP -0.4 0.00101 NA
144 hsa-miR-28-5p WIF1 -0.43 0 0.56 0.11285 miRanda -0.5 0.00804 NA
145 hsa-miR-378a-3p WNT10A -1.19 0 -0.7 0.01484 MirTarget; miRNATAP -0.31 1.0E-5 NA
146 hsa-miR-664a-3p WNT10A 0.49 0.00073 -0.7 0.01484 mirMAP -0.33 0.00058 NA
147 hsa-miR-362-3p WNT2 0.81 0 -3.92 0 miRanda -0.6 7.0E-5 NA
148 hsa-miR-532-5p WNT2 1.03 0 -3.92 0 miRNATAP -1.17 0 NA
149 hsa-miR-548b-3p WNT2 -0.02 0.93082 -3.92 0 MirTarget -0.5 0 NA
150 hsa-miR-616-5p WNT2B 0.15 0.40284 0.92 9.0E-5 mirMAP -0.36 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 WNT SIGNALING PATHWAY 39 351 2.026e-58 9.427e-55
2 NON CANONICAL WNT SIGNALING PATHWAY 21 140 1.872e-32 4.355e-29
3 REGULATION OF WNT SIGNALING PATHWAY 25 310 7.079e-32 1.098e-28
4 CANONICAL WNT SIGNALING PATHWAY 18 95 1.031e-29 1.199e-26
5 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 20 197 2.642e-27 2.426e-24
6 REGULATION OF ORGAN MORPHOGENESIS 21 242 3.129e-27 2.426e-24
7 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 20 236 1.093e-25 7.264e-23
8 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 29 1021 2.646e-24 1.539e-21
9 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 17 162 2.025e-23 1.047e-20
10 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 33 1672 3.193e-23 1.486e-20
11 REGULATION OF EMBRYONIC DEVELOPMENT 15 114 3.154e-22 1.334e-19
12 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 13 110 1.077e-18 4.177e-16
13 EPITHELIUM DEVELOPMENT 24 945 1.391e-18 4.978e-16
14 ORGAN MORPHOGENESIS 22 841 3.302e-17 1.098e-14
15 REGULATION OF CELL DIFFERENTIATION 26 1492 2.962e-16 9.187e-14
16 TISSUE MORPHOGENESIS 18 533 6.384e-16 1.857e-13
17 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 23 1142 1.461e-15 3.998e-13
18 MORPHOGENESIS OF AN EPITHELIUM 16 400 2.614e-15 6.402e-13
19 TUBE MORPHOGENESIS 15 323 2.507e-15 6.402e-13
20 NEGATIVE REGULATION OF CELL COMMUNICATION 23 1192 3.671e-15 8.54e-13
21 TISSUE DEVELOPMENT 25 1518 5.39e-15 1.194e-12
22 TUBE DEVELOPMENT 17 552 2.201e-14 4.655e-12
23 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 23 1360 6.104e-14 1.235e-11
24 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 8 39 6.872e-14 1.332e-11
25 POSITIVE REGULATION OF CELL DIFFERENTIATION 19 823 8.14e-14 1.515e-11
26 NEUROGENESIS 23 1402 1.161e-13 2.078e-11
27 NEURAL TUBE DEVELOPMENT 11 149 1.255e-13 2.163e-11
28 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 11 152 1.566e-13 2.602e-11
29 NEURON DIFFERENTIATION 19 874 2.377e-13 3.814e-11
30 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 16 554 3.998e-13 6.202e-11
31 REGULATION OF CATENIN IMPORT INTO NUCLEUS 7 27 4.502e-13 6.757e-11
32 MORPHOGENESIS OF EMBRYONIC EPITHELIUM 10 134 1.616e-12 2.349e-10
33 EMBRYONIC MORPHOGENESIS 15 539 4.238e-12 5.976e-10
34 SENSORY ORGAN DEVELOPMENT 14 493 1.911e-11 2.615e-09
35 POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 9 119 2.041e-11 2.713e-09
36 TUBE FORMATION 9 129 4.241e-11 5.481e-09
37 EMBRYO DEVELOPMENT 17 894 4.905e-11 6.168e-09
38 POSITIVE REGULATION OF CELL COMMUNICATION 21 1532 6.166e-11 7.55e-09
39 MIDBRAIN DEVELOPMENT 8 90 7.834e-11 9.347e-09
40 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 16 801 1.014e-10 1.18e-08
41 NEURAL TUBE FORMATION 8 94 1.116e-10 1.267e-08
42 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 12 365 1.221e-10 1.337e-08
43 REGULATION OF CELL FATE SPECIFICATION 5 13 1.235e-10 1.337e-08
44 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY INVOLVED IN NEURAL TUBE CLOSURE 5 14 1.918e-10 2.028e-08
45 HEAD DEVELOPMENT 15 709 2.005e-10 2.074e-08
46 CELL FATE COMMITMENT 10 227 3.034e-10 3.069e-08
47 RESPONSE TO RETINOIC ACID 8 107 3.186e-10 3.154e-08
48 CELLULAR RESPONSE TO RETINOIC ACID 7 65 3.274e-10 3.174e-08
49 PATTERN SPECIFICATION PROCESS 12 418 5.758e-10 5.468e-08
50 POSITIVE REGULATION OF GENE EXPRESSION 21 1733 6.053e-10 5.633e-08
51 POSITIVE REGULATION OF RESPONSE TO STIMULUS 22 1929 6.241e-10 5.694e-08
52 POSITIVE REGULATION OF MOLECULAR FUNCTION 21 1791 1.105e-09 9.741e-08
53 CELL PROLIFERATION 14 672 1.11e-09 9.741e-08
54 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 16 957 1.362e-09 1.174e-07
55 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 19 1492 2.403e-09 2.033e-07
56 CENTRAL NERVOUS SYSTEM DEVELOPMENT 15 872 3.432e-09 2.852e-07
57 HEART MORPHOGENESIS 9 212 3.534e-09 2.885e-07
58 NEGATIVE REGULATION OF EMBRYONIC DEVELOPMENT 5 26 6.155e-09 4.854e-07
59 REGULATION OF CELL FATE COMMITMENT 5 26 6.155e-09 4.854e-07
60 REGIONALIZATION 10 311 6.353e-09 4.927e-07
61 CELL DEVELOPMENT 18 1426 8.415e-09 6.288e-07
62 CARDIOVASCULAR SYSTEM DEVELOPMENT 14 788 8.514e-09 6.288e-07
63 CIRCULATORY SYSTEM DEVELOPMENT 14 788 8.514e-09 6.288e-07
64 STEM CELL PROLIFERATION 6 60 1.031e-08 7.499e-07
65 SOMITOGENESIS 6 62 1.262e-08 9.031e-07
66 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 20 1848 1.288e-08 9.082e-07
67 CELLULAR RESPONSE TO ACID CHEMICAL 8 175 1.586e-08 1.102e-06
68 NEGATIVE REGULATION OF GENE EXPRESSION 18 1493 1.722e-08 1.178e-06
69 REGULATION OF CELL PROLIFERATION 18 1496 1.777e-08 1.198e-06
70 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 18 1517 2.206e-08 1.445e-06
71 POSITIVE REGULATION OF EMBRYONIC DEVELOPMENT 5 33 2.191e-08 1.445e-06
72 BRAIN MORPHOGENESIS 5 34 2.563e-08 1.657e-06
73 NEURAL PRECURSOR CELL PROLIFERATION 6 70 2.649e-08 1.688e-06
74 REGULATION OF GASTRULATION 5 35 2.985e-08 1.877e-06
75 ANTERIOR POSTERIOR PATTERN SPECIFICATION 8 194 3.543e-08 2.198e-06
76 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 8 197 3.991e-08 2.443e-06
77 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 17 1395 4.185e-08 2.529e-06
78 SOMITE DEVELOPMENT 6 78 5.107e-08 3.047e-06
79 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 19 1805 5.388e-08 3.158e-06
80 REGULATION OF MESODERM DEVELOPMENT 4 15 5.429e-08 3.158e-06
81 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 11 513 6.633e-08 3.81e-06
82 EMBRYONIC ORGAN DEVELOPMENT 10 406 7.869e-08 4.465e-06
83 REPRODUCTIVE SYSTEM DEVELOPMENT 10 408 8.238e-08 4.618e-06
84 SEGMENTATION 6 89 1.131e-07 6.263e-06
85 RESPONSE TO ACID CHEMICAL 9 319 1.202e-07 6.547e-06
86 POST ANAL TAIL MORPHOGENESIS 4 18 1.21e-07 6.547e-06
87 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 14 983 1.346e-07 7.198e-06
88 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 7 154 1.4e-07 7.405e-06
89 DIGESTIVE TRACT MORPHOGENESIS 5 48 1.535e-07 8.024e-06
90 REGULATION OF JNK CASCADE 7 159 1.742e-07 9.005e-06
91 SENSORY ORGAN MORPHOGENESIS 8 239 1.769e-07 9.046e-06
92 CELLULAR RESPONSE TO LIPID 10 457 2.357e-07 1.18e-05
93 IMMUNE SYSTEM DEVELOPMENT 11 582 2.359e-07 1.18e-05
94 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 14 1036 2.558e-07 1.253e-05
95 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 14 1036 2.558e-07 1.253e-05
96 REGULATION OF MUSCLE TISSUE DEVELOPMENT 6 103 2.706e-07 1.298e-05
97 REGULATION OF MUSCLE ORGAN DEVELOPMENT 6 103 2.706e-07 1.298e-05
98 HEART DEVELOPMENT 10 466 2.821e-07 1.339e-05
99 SOMATIC STEM CELL DIVISION 4 22 2.87e-07 1.349e-05
100 RESPONSE TO LIPID 13 888 3.032e-07 1.411e-05
101 OUTFLOW TRACT MORPHOGENESIS 5 56 3.37e-07 1.553e-05
102 REGULATION OF PHOSPHORUS METABOLIC PROCESS 17 1618 3.562e-07 1.625e-05
103 NEGATIVE REGULATION OF CELL DIFFERENTIATION 11 609 3.705e-07 1.674e-05
104 REGULATION OF OSTEOBLAST DIFFERENTIATION 6 112 4.448e-07 1.99e-05
105 REGULATION OF PROTEIN IMPORT 7 183 4.524e-07 2.005e-05
106 REGULATION OF STEM CELL DIFFERENTIATION 6 113 4.688e-07 2.058e-05
107 MAMMARY GLAND DEVELOPMENT 6 117 5.758e-07 2.488e-05
108 MESENCHYME DEVELOPMENT 7 190 5.828e-07 2.488e-05
109 STEM CELL DIFFERENTIATION 7 190 5.828e-07 2.488e-05
110 REGULATION OF EPITHELIAL CELL PROLIFERATION 8 285 6.736e-07 2.849e-05
111 AXIS ELONGATION 4 27 6.821e-07 2.859e-05
112 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 12 799 7.204e-07 2.985e-05
113 GLAND DEVELOPMENT 9 395 7.25e-07 2.985e-05
114 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 14 1135 7.702e-07 3.144e-05
115 REGULATION OF PROTEIN MODIFICATION PROCESS 17 1710 7.78e-07 3.148e-05
116 DOPAMINERGIC NEURON DIFFERENTIATION 4 28 7.942e-07 3.186e-05
117 POSITIVE REGULATION OF CATALYTIC ACTIVITY 16 1518 8.424e-07 3.35e-05
118 POSITIVE REGULATION OF CELL PROLIFERATION 12 814 8.766e-07 3.457e-05
119 STEM CELL DIVISION 4 29 9.195e-07 3.595e-05
120 UROGENITAL SYSTEM DEVELOPMENT 8 299 9.662e-07 3.746e-05
121 SKIN EPIDERMIS DEVELOPMENT 5 71 1.116e-06 4.29e-05
122 REGULATION OF CELLULAR RESPONSE TO STRESS 11 691 1.284e-06 4.897e-05
123 REGULATION OF ORGAN FORMATION 4 32 1.384e-06 5.235e-05
124 G PROTEIN COUPLED RECEPTOR SIGNALING PATHWAY 14 1193 1.395e-06 5.235e-05
125 RESPONSE TO OXYGEN CONTAINING COMPOUND 15 1381 1.408e-06 5.243e-05
126 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 7 218 1.465e-06 5.408e-05
127 MUSCLE STRUCTURE DEVELOPMENT 9 432 1.522e-06 5.575e-05
128 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 7 220 1.556e-06 5.658e-05
129 CELL ACTIVATION 10 568 1.705e-06 6.15e-05
130 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 7 228 1.974e-06 7.065e-05
131 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 7 229 2.032e-06 7.218e-05
132 REGULATION OF JUN KINASE ACTIVITY 5 81 2.153e-06 7.588e-05
133 KIDNEY MORPHOGENESIS 5 82 2.288e-06 8.004e-05
134 HAIR CYCLE 5 83 2.43e-06 8.375e-05
135 MOLTING CYCLE 5 83 2.43e-06 8.375e-05
136 CELLULAR COMPONENT MORPHOGENESIS 12 900 2.503e-06 8.565e-05
137 POSITIVE REGULATION OF GROWTH 7 238 2.624e-06 8.912e-05
138 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 11 750 2.84e-06 9.577e-05
139 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 10 602 2.867e-06 9.598e-05
140 GASTRULATION 6 155 2.983e-06 9.851e-05
141 VASCULATURE DEVELOPMENT 9 469 2.985e-06 9.851e-05
142 REGULATION OF WNT SIGNALING PATHWAY PLANAR CELL POLARITY PATHWAY 3 12 3.587e-06 0.0001175
143 FOREBRAIN DEVELOPMENT 8 357 3.615e-06 0.0001176
144 INNER EAR MORPHOGENESIS 5 92 4.044e-06 0.0001307
145 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 4 42 4.227e-06 0.0001356
146 NEGATIVE REGULATION OF STEM CELL DIFFERENTIATION 4 43 4.651e-06 0.0001452
147 MORPHOGENESIS OF A BRANCHING STRUCTURE 6 167 4.589e-06 0.0001452
148 BETA CATENIN TCF COMPLEX ASSEMBLY 4 43 4.651e-06 0.0001452
149 EPITHELIAL CELL DIFFERENTIATION 9 495 4.629e-06 0.0001452
150 CELLULAR RESPONSE TO EXTERNAL STIMULUS 7 264 5.196e-06 0.0001612
151 SEX DIFFERENTIATION 7 266 5.46e-06 0.0001682
152 CONVERGENT EXTENSION 3 14 5.913e-06 0.000181
153 REGULATION OF MAPK CASCADE 10 660 6.468e-06 0.0001967
154 REGULATION OF OSSIFICATION 6 178 6.622e-06 0.0002001
155 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 16 1784 6.966e-06 0.0002091
156 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 4 48 7.264e-06 0.0002166
157 CARDIAC CHAMBER MORPHOGENESIS 5 104 7.386e-06 0.0002175
158 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 5 104 7.386e-06 0.0002175
159 EMBRYONIC ORGAN MORPHOGENESIS 7 279 7.459e-06 0.0002183
160 REGULATION OF FAT CELL DIFFERENTIATION 5 106 8.108e-06 0.0002358
161 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 6 188 9.053e-06 0.0002616
162 POSITIVE REGULATION OF FAT CELL DIFFERENTIATION 4 51 9.275e-06 0.0002664
163 EAR MORPHOGENESIS 5 112 1.061e-05 0.0003028
164 MAMMARY GLAND EPITHELIUM DEVELOPMENT 4 53 1.083e-05 0.0003072
165 ESTABLISHMENT OF TISSUE POLARITY 3 17 1.099e-05 0.0003098
166 REGULATION OF KIDNEY DEVELOPMENT 4 55 1.256e-05 0.0003521
167 EPITHELIAL TO MESENCHYMAL TRANSITION 4 56 1.35e-05 0.0003762
168 REGULATION OF PROTEIN TARGETING 7 307 1.388e-05 0.0003844
169 REGULATION OF NON CANONICAL WNT SIGNALING PATHWAY 3 19 1.56e-05 0.0004244
170 REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 3 19 1.56e-05 0.0004244
171 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 5 121 1.544e-05 0.0004244
172 POSITIVE REGULATION OF HYDROLASE ACTIVITY 11 905 1.684e-05 0.0004535
173 RESPONSE TO EXTRACELLULAR STIMULUS 8 441 1.686e-05 0.0004535
174 SKIN DEVELOPMENT 6 211 1.745e-05 0.0004665
175 CHONDROCYTE DIFFERENTIATION 4 60 1.779e-05 0.000473
176 REPRODUCTION 13 1297 1.985e-05 0.0005235
177 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 6 216 1.991e-05 0.0005235
178 EYE DEVELOPMENT 7 326 2.044e-05 0.0005342
179 NEGATIVE REGULATION OF TRANSPORT 8 458 2.212e-05 0.000575
180 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 5 131 2.267e-05 0.0005861
181 BETA CATENIN DESTRUCTION COMPLEX DISASSEMBLY 3 22 2.465e-05 0.0006338
182 REGULATION OF HYDROLASE ACTIVITY 13 1327 2.527e-05 0.000636
183 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 7 337 2.528e-05 0.000636
184 MESENCHYMAL CELL DIFFERENTIATION 5 134 2.529e-05 0.000636
185 REGULATION OF CELLULAR COMPONENT MOVEMENT 10 771 2.49e-05 0.000636
186 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 5 135 2.621e-05 0.0006486
187 REGULATION OF CELL CYCLE 11 949 2.615e-05 0.0006486
188 LENS DEVELOPMENT IN CAMERA TYPE EYE 4 66 2.599e-05 0.0006486
189 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 8 470 2.661e-05 0.0006551
190 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 4 67 2.759e-05 0.0006756
191 RESPONSE TO GROWTH FACTOR 8 475 2.869e-05 0.000699
192 REGULATION OF CELL ADHESION 9 629 3.122e-05 0.0007566
193 REGULATION OF GROWTH 9 633 3.281e-05 0.000787
194 MUSCLE ORGAN MORPHOGENESIS 4 70 3.281e-05 0.000787
195 NEGATIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 4 71 3.471e-05 0.0008281
196 CARDIAC CHAMBER DEVELOPMENT 5 144 3.572e-05 0.0008438
197 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 5 144 3.572e-05 0.0008438
198 REGULATION OF TRANSPORT 15 1804 3.609e-05 0.0008482
199 CARTILAGE DEVELOPMENT 5 147 3.943e-05 0.0009219
200 DIGESTIVE SYSTEM DEVELOPMENT 5 148 4.073e-05 0.0009381
201 POSITIVE REGULATION OF CELL GROWTH 5 148 4.073e-05 0.0009381
202 MALE SEX DIFFERENTIATION 5 148 4.073e-05 0.0009381
203 BLOOD VESSEL MORPHOGENESIS 7 364 4.129e-05 0.0009465
204 DEVELOPMENTAL INDUCTION 3 27 4.64e-05 0.001053
205 REGULATION OF MUSCLE CELL DIFFERENTIATION 5 152 4.626e-05 0.001053
206 REGULATION OF BMP SIGNALING PATHWAY 4 77 4.778e-05 0.001079
207 REGULATION OF CELL DEVELOPMENT 10 836 4.949e-05 0.001113
208 VENTRICULAR SEPTUM MORPHOGENESIS 3 28 5.187e-05 0.001155
209 MORPHOGENESIS OF A POLARIZED EPITHELIUM 3 28 5.187e-05 0.001155
210 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 7 381 5.51e-05 0.001221
211 NEUROBLAST PROLIFERATION 3 29 5.775e-05 0.001273
212 REGULATION OF FIBROBLAST PROLIFERATION 4 81 5.83e-05 0.00128
213 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 14 1656 5.901e-05 0.001289
214 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 5 162 6.264e-05 0.001362
215 RESPONSE TO X RAY 3 30 6.405e-05 0.001386
216 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 4 84 6.722e-05 0.001448
217 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 4 85 7.041e-05 0.001496
218 PALATE DEVELOPMENT 4 85 7.041e-05 0.001496
219 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 5 166 7.032e-05 0.001496
220 REGULATION OF CELL DIVISION 6 272 7.213e-05 0.001526
221 REGULATION OF CELL DEATH 13 1472 7.424e-05 0.001563
222 REGULATION OF STEM CELL PROLIFERATION 4 88 8.062e-05 0.00169
223 REGULATION OF CELL SUBSTRATE ADHESION 5 173 8.549e-05 0.001784
224 LEUKOCYTE ACTIVATION 7 414 9.274e-05 0.001926
225 REGULATION OF DEVELOPMENTAL GROWTH 6 289 0.0001007 0.002073
226 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 289 0.0001007 0.002073
227 LEUKOCYTE DIFFERENTIATION 6 292 0.0001065 0.002184
228 IMMUNE SYSTEM PROCESS 15 1984 0.0001079 0.002202
229 NEGATIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 4 95 0.0001086 0.002207
230 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 9 740 0.0001093 0.002211
231 NEGATIVE REGULATION OF MUSCLE ORGAN DEVELOPMENT 3 36 0.0001114 0.002234
232 NEGATIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 3 36 0.0001114 0.002234
233 RESPONSE TO DRUG 7 431 0.0001191 0.002378
234 REGULATION OF RECEPTOR INTERNALIZATION 3 37 0.000121 0.002406
235 CELL CELL SIGNALING 9 767 0.0001433 0.002825
236 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 4 102 0.000143 0.002825
237 CONNECTIVE TISSUE DEVELOPMENT 5 194 0.0001464 0.002875
238 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 11 1152 0.0001502 0.002924
239 EAR DEVELOPMENT 5 195 0.00015 0.002924
240 POSITIVE REGULATION OF CELL DEATH 8 605 0.0001557 0.003018
241 REGULATION OF KINASE ACTIVITY 9 776 0.0001565 0.003021
242 RESPIRATORY SYSTEM DEVELOPMENT 5 197 0.0001573 0.003024
243 POSITIVE REGULATION OF KIDNEY DEVELOPMENT 3 41 0.0001648 0.003126
244 NEGATIVE REGULATION OF STRESS ACTIVATED MAPK CASCADE 3 41 0.0001648 0.003126
245 CARDIAC VENTRICLE DEVELOPMENT 4 106 0.0001659 0.003126
246 FAT CELL DIFFERENTIATION 4 106 0.0001659 0.003126
247 NEGATIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 3 41 0.0001648 0.003126
248 REGULATION OF MAP KINASE ACTIVITY 6 319 0.0001725 0.003236
249 SINGLE ORGANISM CELL ADHESION 7 459 0.0001756 0.003281
250 REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 4 108 0.0001783 0.003319
251 FORMATION OF PRIMARY GERM LAYER 4 110 0.0001914 0.003547
252 LABYRINTHINE LAYER DEVELOPMENT 3 44 0.0002036 0.003745
253 POSITIVE REGULATION OF MAPK CASCADE 7 470 0.000203 0.003745
254 NEGATIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 5 209 0.0002071 0.003779
255 LYMPHOCYTE DIFFERENTIATION 5 209 0.0002071 0.003779
256 POSITIVE REGULATION OF CELL DEVELOPMENT 7 472 0.0002083 0.003786
257 DEVELOPMENTAL GROWTH 6 333 0.0002175 0.003939
258 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 10 1004 0.0002243 0.004045
259 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 5 213 0.0002261 0.004062
260 NEPHRON DEVELOPMENT 4 115 0.000227 0.004062
261 REGULATION OF CYTOPLASMIC TRANSPORT 7 481 0.0002338 0.004167
262 NEGATIVE REGULATION OF CELL PROLIFERATION 8 643 0.0002357 0.004187
263 POSITIVE REGULATION OF KINASE ACTIVITY 7 482 0.0002367 0.004188
264 NEGATIVE REGULATION OF CYTOPLASMIC TRANSPORT 4 117 0.0002425 0.004241
265 SPECIFICATION OF SYMMETRY 4 117 0.0002425 0.004241
266 CELLULAR RESPONSE TO STARVATION 4 117 0.0002425 0.004241
267 LYMPHOCYTE ACTIVATION 6 342 0.0002511 0.004376
268 CARDIAC SEPTUM MORPHOGENESIS 3 49 0.0002807 0.004873
269 T CELL DIFFERENTIATION 4 123 0.0002935 0.005077
270 REGULATION OF SKELETAL MUSCLE TISSUE DEVELOPMENT 3 50 0.0002981 0.005137
271 REGULATION OF RESPONSE TO STRESS 12 1468 0.0003064 0.005261
272 KIDNEY EPITHELIUM DEVELOPMENT 4 125 0.0003122 0.00534
273 REGULATION OF GTPASE ACTIVITY 8 673 0.0003206 0.005464
274 OSTEOBLAST DIFFERENTIATION 4 126 0.0003218 0.005464
275 HEPATICOBILIARY SYSTEM DEVELOPMENT 4 128 0.0003416 0.005781
276 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 3 53 0.0003543 0.005951
277 POSITIVE REGULATION OF FIBROBLAST PROLIFERATION 3 53 0.0003543 0.005951
278 POSITIVE REGULATION OF CELL FATE COMMITMENT 2 11 0.0003592 0.00597
279 CARDIAC CELL FATE COMMITMENT 2 11 0.0003592 0.00597
280 POSITIVE REGULATION OF NON CANONICAL WNT SIGNALING PATHWAY 2 11 0.0003592 0.00597
281 NEGATIVE REGULATION OF GROWTH 5 236 0.0003627 0.006006
282 NEGATIVE REGULATION OF CELL DEATH 9 872 0.0003717 0.006134
283 VENTRICULAR SEPTUM DEVELOPMENT 3 54 0.0003744 0.006156
284 NEGATIVE REGULATION OF MOLECULAR FUNCTION 10 1079 0.000399 0.006538
285 NEGATIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 4 135 0.0004181 0.006779
286 POSITIVE REGULATION OF CELL ADHESION 6 376 0.0004163 0.006779
287 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 3 56 0.0004169 0.006779
288 POSITIVE REGULATION BY HOST OF VIRAL TRANSCRIPTION 2 12 0.0004304 0.006881
289 HEART FORMATION 2 12 0.0004304 0.006881
290 POSITIVE REGULATION OF CATENIN IMPORT INTO NUCLEUS 2 12 0.0004304 0.006881
291 LENS FIBER CELL DEVELOPMENT 2 12 0.0004304 0.006881
292 OSSIFICATION 5 251 0.0004806 0.007658
293 VASCULOGENESIS 3 59 0.0004863 0.007722
294 EPIDERMIS DEVELOPMENT 5 253 0.0004982 0.007885
295 NEURONAL STEM CELL DIVISION 2 13 0.0005078 0.007928
296 FC EPSILON RECEPTOR SIGNALING PATHWAY 4 142 0.0005062 0.007928
297 HEMATOPOIETIC STEM CELL PROLIFERATION 2 13 0.0005078 0.007928
298 NEUROBLAST DIVISION 2 13 0.0005078 0.007928
299 REGULATION OF CELL GROWTH 6 391 0.0005119 0.007939
300 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 3 60 0.0005109 0.007939
301 NEGATIVE REGULATION OF INTRACELLULAR TRANSPORT 4 143 0.0005198 0.008035
302 POSITIVE REGULATION OF STEM CELL PROLIFERATION 3 61 0.0005364 0.00821
303 REGULATION OF CELLULAR PROTEIN LOCALIZATION 7 552 0.0005355 0.00821
304 REGULATION OF CELL MORPHOGENESIS 7 552 0.0005355 0.00821
305 RESPONSE TO IONIZING RADIATION 4 145 0.0005477 0.008355
306 EMBRYONIC HEART TUBE MORPHOGENESIS 3 62 0.0005626 0.008555
307 INTRACELLULAR SIGNAL TRANSDUCTION 12 1572 0.000571 0.008626
308 REGULATION OF CELL CYCLE PROCESS 7 558 0.000571 0.008626
309 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 5 263 0.000594 0.008774
310 NEGATIVE REGULATION OF LOCOMOTION 5 263 0.000594 0.008774
311 NEGATIVE REGULATION OF JUN KINASE ACTIVITY 2 14 0.0005914 0.008774
312 POSITIVE REGULATION OF MEIOTIC CELL CYCLE 2 14 0.0005914 0.008774
313 REGULATION OF MONOCYTE DIFFERENTIATION 2 14 0.0005914 0.008774
314 POSITIVE REGULATION OF JUN KINASE ACTIVITY 3 63 0.0005897 0.008774
315 CELLULAR RESPONSE TO VITAMIN D 2 14 0.0005914 0.008774
316 RESPONSE TO WOUNDING 7 563 0.000602 0.008864
317 GROWTH 6 410 0.0006566 0.009638
318 REGULATION OF TRANSFERASE ACTIVITY 9 946 0.0006706 0.009813
319 FOREBRAIN GENERATION OF NEURONS 3 66 0.0006758 0.009826
320 MESODERM MORPHOGENESIS 3 66 0.0006758 0.009826
321 MESENCHYMAL TO EPITHELIAL TRANSITION 2 15 0.0006813 0.009857
322 RESPONSE TO RADIATION 6 413 0.0006821 0.009857
323 RESPONSE TO STARVATION 4 154 0.0006866 0.009891
NumGOOverlapSizeP ValueAdj. P Value
1 WNT PROTEIN BINDING 13 31 9.674e-27 7.14e-24
2 WNT ACTIVATED RECEPTOR ACTIVITY 12 22 1.537e-26 7.14e-24
3 FRIZZLED BINDING 10 36 1.359e-18 4.208e-16
4 G PROTEIN COUPLED RECEPTOR BINDING 10 259 1.094e-09 2.541e-07
5 SIGNAL TRANSDUCER ACTIVITY 20 1731 4.197e-09 7.797e-07
6 BETA CATENIN BINDING 6 84 7.987e-08 1.06e-05
7 RECEPTOR AGONIST ACTIVITY 4 16 7.224e-08 1.06e-05
8 PDZ DOMAIN BINDING 6 90 1.209e-07 1.248e-05
9 RECEPTOR REGULATOR ACTIVITY 5 45 1.101e-07 1.248e-05
10 RECEPTOR BINDING 16 1476 5.787e-07 5.376e-05
11 RECEPTOR ACTIVATOR ACTIVITY 4 32 1.384e-06 0.0001169
12 G PROTEIN COUPLED RECEPTOR ACTIVITY 12 879 1.959e-06 0.0001517
13 PROTEIN DOMAIN SPECIFIC BINDING 10 624 3.944e-06 0.0002818
14 MOLECULAR FUNCTION REGULATOR 14 1353 6.084e-06 0.0004037
15 TRANSCRIPTION FACTOR BINDING 9 524 7.33e-06 0.0004539
16 SIGNALING RECEPTOR ACTIVITY 13 1393 4.201e-05 0.002439
17 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 4 90 8.8e-05 0.004809
18 ENZYME BINDING 14 1737 9.905e-05 0.005112
19 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 6 315 0.0001611 0.007876
NumGOOverlapSizeP ValueAdj. P Value
1 ENDOCYTIC VESICLE MEMBRANE 8 152 5.244e-09 3.062e-06
2 EXTRACELLULAR MATRIX 10 426 1.231e-07 3.594e-05
3 ENDOCYTIC VESICLE 8 256 2.988e-07 4.437e-05
4 PROTEINACEOUS EXTRACELLULAR MATRIX 9 356 3.039e-07 4.437e-05
5 CELL SURFACE 12 757 4.062e-07 4.745e-05
6 VESICLE MEMBRANE 9 512 6.082e-06 0.0005074
7 BETA CATENIN DESTRUCTION COMPLEX 3 14 5.913e-06 0.0005074
8 EXTRACELLULAR SPACE 14 1376 7.388e-06 0.0005393
9 CYTOPLASMIC VESICLE PART 9 601 2.184e-05 0.001417
10 TRANSCRIPTIONAL REPRESSOR COMPLEX 4 74 4.086e-05 0.002386
11 GOLGI LUMEN 4 94 0.0001042 0.005533

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04310_Wnt_signaling_pathway 52 151 2.193e-115 3.882e-113
2 hsa04916_Melanogenesis 23 101 3.18e-40 2.815e-38
3 hsa04340_Hedgehog_signaling_pathway 8 56 1.535e-12 9.055e-11
4 hsa04912_GnRH_signaling_pathway 8 101 1.999e-10 8.845e-09
5 hsa04720_Long.term_potentiation 6 70 2.649e-08 9.376e-07
6 hsa04971_Gastric_acid_secretion 6 74 3.713e-08 1.095e-06
7 hsa04012_ErbB_signaling_pathway 6 87 9.864e-08 2.494e-06
8 hsa04662_B_cell_receptor_signaling_pathway 5 75 1.467e-06 3.246e-05
9 hsa04010_MAPK_signaling_pathway 7 268 5.734e-06 0.0001128
10 hsa04020_Calcium_signaling_pathway 6 177 6.411e-06 0.0001135
11 hsa04510_Focal_adhesion 6 200 1.288e-05 0.0002072
12 hsa04520_Adherens_junction 4 73 3.873e-05 0.0005712
13 hsa04370_VEGF_signaling_pathway 4 76 4.539e-05 0.000618
14 hsa04970_Salivary_secretion 4 89 8.425e-05 0.001038
15 hsa04540_Gap_junction 4 90 8.8e-05 0.001038
16 hsa04270_Vascular_smooth_muscle_contraction 4 116 0.0002346 0.002596
17 hsa04722_Neurotrophin_signaling_pathway 4 127 0.0003316 0.003359
18 hsa04380_Osteoclast_differentiation 4 128 0.0003416 0.003359
19 hsa04650_Natural_killer_cell_mediated_cytotoxicity 4 136 0.00043 0.004006
20 hsa04730_Long.term_depression 3 70 0.0008025 0.007102
21 hsa04070_Phosphatidylinositol_signaling_system 3 78 0.001099 0.009175
22 hsa04664_Fc_epsilon_RI_signaling_pathway 3 79 0.00114 0.009175
23 hsa04062_Chemokine_signaling_pathway 4 189 0.001468 0.0113
24 hsa04972_Pancreatic_secretion 3 101 0.002309 0.01703
25 hsa04660_T_cell_receptor_signaling_pathway 3 108 0.002792 0.01977
26 hsa04114_Oocyte_meiosis 3 114 0.003253 0.02215
27 hsa04110_Cell_cycle 3 128 0.004502 0.02951
28 hsa04360_Axon_guidance 3 130 0.004701 0.02972
29 hsa04630_Jak.STAT_signaling_pathway 3 155 0.007643 0.04665
30 hsa00562_Inositol_phosphate_metabolism 2 57 0.009658 0.05698
31 hsa04115_p53_signaling_pathway 2 69 0.01392 0.07947
32 hsa04914_Progesterone.mediated_oocyte_maturation 2 87 0.02155 0.1192
33 hsa04620_Toll.like_receptor_signaling_pathway 2 102 0.02895 0.1553
34 hsa04530_Tight_junction 2 133 0.04689 0.2441
35 hsa04910_Insulin_signaling_pathway 2 138 0.05009 0.2533
36 hsa04740_Olfactory_transduction 3 388 0.07987 0.3927
37 hsa04810_Regulation_of_actin_cytoskeleton 2 214 0.1068 0.4794

Quest ID: 3ee26fe5680f0f4589d7f8374a585b83