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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-27a-3p A1CF -0.37 0.00876 -0.98 1.0E-5 MirTarget -0.55 0 NA
2 hsa-miR-106b-5p AADAC 0.65 0 -1.53 0 MirTarget -0.77 0 NA
3 hsa-miR-421 AASDH 0.94 0 -0.44 0 miRanda -0.12 0 NA
4 hsa-miR-182-5p AASS 1.97 0 -1.86 0 MirTarget -0.24 0 NA
5 hsa-miR-218-5p ABAT -0.5 0.03986 -2.16 0 mirMAP -0.18 0.00036 NA
6 hsa-miR-27a-3p ABAT -0.37 0.00876 -2.16 0 MirTarget -0.5 0 NA
7 hsa-miR-421 ABAT 0.94 0 -2.16 0 PITA; miRanda; miRNATAP -0.63 0 NA
8 hsa-miR-106b-5p ABCA1 0.65 0 -1.1 0 MirTarget; miRNATAP -0.19 0.00194 NA
9 hsa-miR-27a-3p ABCA1 -0.37 0.00876 -1.1 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.15 0.00176 NA
10 hsa-miR-301a-3p ABCA1 0.84 0 -1.1 0 miRNATAP -0.13 0.00125 NA
11 hsa-miR-421 ABCA5 0.94 0 -0.14 0.30791 miRanda -0.14 0.00018 NA
12 hsa-miR-421 ABCA6 0.94 0 -1.73 0 miRanda -0.53 0 NA
13 hsa-miR-421 ABCB1 0.94 0 -0.9 0.00459 miRanda -0.32 0.00022 NA
14 hsa-miR-421 ABCB11 0.94 0 -2.63 0 miRanda; miRNATAP -0.73 0 NA
15 hsa-miR-421 ABCB4 0.94 0 -1.52 0 miRanda -0.52 0 NA
16 hsa-miR-301a-3p ABCB7 0.84 0 -0.34 4.0E-5 MirTarget; miRNATAP -0.11 0 NA
17 hsa-miR-421 ABCC6P1 0.94 0 -0.64 0.01293 miRanda -0.34 0 NA
18 hsa-miR-25-3p ABHD13 0.63 0 -0.68 0 miRNATAP -0.14 0.00082 NA
19 hsa-miR-421 ABHD14B 0.94 0 -0.88 0 mirMAP -0.26 0 NA
20 hsa-miR-940 ABHD14B 0.45 0.01771 -0.88 0 MirTarget; miRNATAP -0.2 0 NA
21 hsa-miR-106b-5p ABHD2 0.65 0 -1.2 0 miRNATAP -0.46 0 NA
22 hsa-miR-301a-3p ABHD2 0.84 0 -1.2 0 mirMAP -0.38 0 NA
23 hsa-miR-940 ABHD2 0.45 0.01771 -1.2 0 mirMAP -0.17 2.0E-5 NA
24 hsa-miR-106b-5p ABHD5 0.65 0 -0.6 0 MirTarget -0.19 1.0E-5 NA
25 hsa-miR-421 ABHD5 0.94 0 -0.6 0 miRanda -0.17 0 NA
26 hsa-miR-27a-3p ABHD6 -0.37 0.00876 -1.31 0 miRNATAP -0.41 0 NA
27 hsa-miR-421 ABI3BP 0.94 0 -1.96 0 miRanda -0.25 0.00236 NA
28 hsa-miR-25-3p ABLIM1 0.63 0 0.05 0.66786 mirMAP -0.12 0.02419 NA
29 hsa-miR-106b-5p ABTB2 0.65 0 -0.43 0.0031 miRNAWalker2 validate -0.25 5.0E-5 NA
30 hsa-miR-301a-3p ABTB2 0.84 0 -0.43 0.0031 mirMAP -0.21 0 NA
31 hsa-miR-421 ACAD11 0.94 0 -1.86 0 miRanda -0.29 0 NA
32 hsa-miR-421 ACADS 0.94 0 -1.98 0 miRanda -0.41 0 NA
33 hsa-miR-182-5p ACADSB 1.97 0 -2.11 0 mirMAP -0.26 0 NA
34 hsa-miR-421 ACADVL 0.94 0 -0.74 0 miRanda -0.18 0 NA
35 hsa-miR-301a-3p ACBD5 0.84 0 -0.75 0 MirTarget; miRNATAP -0.25 0 NA
36 hsa-miR-421 ACE2 0.94 0 -2.26 0 miRanda -0.67 0 NA
37 hsa-miR-421 ACOT13 0.94 0 -0.49 3.0E-5 miRanda -0.14 4.0E-5 NA
38 hsa-miR-106b-5p ACOX1 0.65 0 -1.16 0 mirMAP -0.51 0 NA
39 hsa-miR-218-5p ACSL1 -0.5 0.03986 -2.33 0 MirTarget; miRNATAP -0.15 0.00314 NA
40 hsa-miR-301a-3p ACSL1 0.84 0 -2.33 0 MirTarget; miRNATAP -0.56 0 NA
41 hsa-miR-106b-5p ACSL6 0.65 0 0.39 0.26458 mirMAP -0.64 2.0E-5 NA
42 hsa-miR-218-5p ACSL6 -0.5 0.03986 0.39 0.26458 miRNATAP -0.38 0 NA
43 hsa-miR-421 ACSM3 0.94 0 -2.91 0 miRanda -0.49 0 NA
44 hsa-miR-106b-5p ACTR3C 0.65 0 -0.99 0 mirMAP -0.5 0 NA
45 hsa-miR-421 ACYP2 0.94 0 -0.82 0 miRanda -0.33 0 NA
46 hsa-miR-25-3p ADAMTSL1 0.63 0 -0.65 0.00587 miRNAWalker2 validate; miRNATAP -0.65 0 NA
47 hsa-miR-421 ADAMTSL1 0.94 0 -0.65 0.00587 miRanda -0.25 0.00015 NA
48 hsa-miR-25-3p ADAMTSL3 0.63 0 -1.86 0 MirTarget; miRNATAP -0.54 0.0002 NA
49 hsa-miR-940 ADAMTSL4 0.45 0.01771 -0.48 0.01202 MirTarget -0.15 0.00256 NA
50 hsa-miR-106b-5p ADARB1 0.65 0 -0.13 0.22208 MirTarget -0.22 0 NA
51 hsa-miR-106b-5p ADCY1 0.65 0 -2.7 0 mirMAP -0.54 0.00112 NA
52 hsa-miR-132-3p ADCY1 0.32 0.00272 -2.7 0 mirMAP -0.61 0.00048 NA
53 hsa-miR-301a-3p ADCY1 0.84 0 -2.7 0 MirTarget; miRNATAP -0.4 0.00018 NA
54 hsa-miR-421 ADCY1 0.94 0 -2.7 0 MirTarget; mirMAP -0.42 9.0E-5 NA
55 hsa-miR-106b-5p ADCY9 0.65 0 -0.11 0.30518 mirMAP -0.23 0 NA
56 hsa-miR-132-3p ADH1A 0.32 0.00272 -2.69 0 miRNAWalker2 validate -1.27 0 NA
57 hsa-miR-421 ADH1C 0.94 0 -3.37 0 miRanda -1.04 0 NA
58 hsa-miR-421 ADH4 0.94 0 -4.41 0 miRanda; mirMAP -0.89 0 NA
59 hsa-miR-106b-5p ADH5 0.65 0 -0.53 0 miRNAWalker2 validate -0.27 0 NA
60 hsa-miR-421 ADH5 0.94 0 -0.53 0 miRanda -0.12 3.0E-5 NA
61 hsa-miR-421 ADI1 0.94 0 -1.25 0 miRanda -0.37 0 NA
62 hsa-miR-25-3p ADM 0.63 0 -1.26 0 miRNATAP -0.2 0.02351 NA
63 hsa-miR-106b-5p ADRA2A 0.65 0 -0.76 0.02558 miRNATAP -0.6 3.0E-5 NA
64 hsa-miR-421 ADRB1 0.94 0 -2.23 0 miRanda -0.4 1.0E-5 NA
65 hsa-miR-106b-5p AEN 0.65 0 0.28 0.01239 MirTarget -0.11 0.02721 NA
66 hsa-miR-132-3p AFF1 0.32 0.00272 -0.71 0 mirMAP -0.2 0.0001 NA
67 hsa-miR-301a-3p AFF1 0.84 0 -0.71 0 MirTarget -0.16 0 NA
68 hsa-miR-421 AFF1 0.94 0 -0.71 0 mirMAP -0.17 0 NA
69 hsa-miR-106b-5p AFF4 0.65 0 -0.64 0 miRNATAP -0.27 0 NA
70 hsa-miR-132-3p AFF4 0.32 0.00272 -0.64 0 mirMAP; miRNATAP -0.24 0 NA
71 hsa-miR-25-3p AFF4 0.63 0 -0.64 0 mirMAP; miRNATAP -0.26 0 NA
72 hsa-miR-421 AFF4 0.94 0 -0.64 0 miRNAWalker2 validate; MirTarget; PITA; miRanda; miRNATAP -0.13 0 NA
73 hsa-miR-940 AFF4 0.45 0.01771 -0.64 0 miRNATAP -0.1 5.0E-5 NA
74 hsa-miR-940 AFMID 0.45 0.01771 -0.39 0.00105 MirTarget -0.14 1.0E-5 NA
75 hsa-miR-106b-5p AGA 0.65 0 0.02 0.86356 MirTarget -0.17 0.00102 NA
76 hsa-miR-218-5p AGBL5 -0.5 0.03986 0.72 0 miRNATAP -0.12 0 NA
77 hsa-miR-27a-3p AGGF1 -0.37 0.00876 0.14 0.03026 miRNATAP -0.12 0 24462738 Role of microRNA 27a in down regulation of angiogenic factor AGGF1 under hypoxia associated with high grade bladder urothelial carcinoma; Hypoxia-induced down-regulation of AGGF1 was mediated by miR-27a; Overexpression of miR-27a suppressed AGGF1 expression through translational inhibition but not by RNA degradation; Moreover the hypoxia-induced decrease of AGGF1 expression disappeared after miR-27a expression was inhibited
78 hsa-miR-421 AGMAT 0.94 0 -1.19 0 MirTarget -0.15 0.00908 NA
79 hsa-miR-27a-3p AGPAT3 -0.37 0.00876 -0.18 0.05507 miRNATAP -0.14 1.0E-5 NA
80 hsa-miR-25-3p AHCYL1 0.63 0 -0.28 0.00031 miRNATAP -0.12 0.00095 NA
81 hsa-miR-421 AHDC1 0.94 0 -0.23 0.02626 miRanda -0.12 5.0E-5 NA
82 hsa-miR-182-5p AHR 1.97 0 -0.97 0 miRNATAP -0.13 0 NA
83 hsa-miR-25-3p AIM1 0.63 0 -1.46 0 miRNAWalker2 validate -0.41 4.0E-5 NA
84 hsa-miR-421 AK2 0.94 0 -0.39 1.0E-5 miRanda -0.12 0 NA
85 hsa-miR-106b-5p AKAP11 0.65 0 -0.7 0 miRNAWalker2 validate -0.25 0 NA
86 hsa-miR-940 AKAP11 0.45 0.01771 -0.7 0 MirTarget -0.12 2.0E-5 NA
87 hsa-miR-25-3p AKAP12 0.63 0 -1.36 0 mirMAP -0.49 0.00019 NA
88 hsa-miR-106b-5p AKAP13 0.65 0 -0.32 0.00142 MirTarget; mirMAP; miRNATAP -0.23 0 NA
89 hsa-miR-421 AKAP13 0.94 0 -0.32 0.00142 miRanda -0.15 0 NA
90 hsa-miR-421 AKAP2 0.94 0 -1.9 0 miRanda -0.25 0.02141 NA
91 hsa-miR-421 AKAP6 0.94 0 -0.97 0 miRanda -0.37 0 NA
92 hsa-miR-421 AKAP7 0.94 0 -0.93 0 miRanda; miRNATAP -0.2 1.0E-5 NA
93 hsa-miR-27a-3p AKIRIN2 -0.37 0.00876 -0.26 0.00807 miRNATAP -0.12 0.00021 NA
94 hsa-miR-421 AKR1A1 0.94 0 -0.54 0 miRanda -0.17 0 NA
95 hsa-miR-182-5p AKR1C1 1.97 0 -0.12 0.65413 mirMAP -0.19 0 NA
96 hsa-miR-218-5p AKR1C1 -0.5 0.03986 -0.12 0.65413 mirMAP -0.28 0 NA
97 hsa-miR-421 AKR1D1 0.94 0 -3.67 0 MirTarget; miRanda; miRNATAP -0.78 0 NA
98 hsa-miR-421 AKR7A2 0.94 0 -0.24 0.02117 miRanda -0.12 7.0E-5 NA
99 hsa-miR-106b-5p AKT3 0.65 0 -0.66 0.00047 miRNATAP -0.26 0.00148 NA
100 hsa-miR-421 AKT3 0.94 0 -0.66 0.00047 miRanda; mirMAP -0.13 0.01091 NA
101 hsa-miR-106b-5p AKTIP 0.65 0 -0.37 0.00054 MirTarget; miRNATAP -0.36 0 NA
102 hsa-miR-27a-3p ALCAM -0.37 0.00876 0.24 0.05364 MirTarget -0.16 0.00029 NA
103 hsa-miR-106b-5p ALDH3A2 0.65 0 -0.55 0.00022 mirMAP -0.45 0 NA
104 hsa-miR-421 ALDH3A2 0.94 0 -0.55 0.00022 miRanda -0.19 1.0E-5 NA
105 hsa-miR-301a-3p ALDH5A1 0.84 0 -1.1 0 mirMAP -0.41 0 NA
106 hsa-miR-421 ALDH6A1 0.94 0 -2.57 0 miRanda -0.55 0 NA
107 hsa-miR-25-3p ALDH7A1 0.63 0 -0.75 0 mirMAP -0.29 0.00016 NA
108 hsa-miR-27a-3p ALDH9A1 -0.37 0.00876 -1.02 0 miRNAWalker2 validate -0.22 0 NA
109 hsa-miR-27a-3p ALG9 -0.37 0.00876 0.16 0.03963 MirTarget -0.12 0 NA
110 hsa-miR-421 ALOX12P2 0.94 0 -0.43 0.1811 miRanda -0.26 0.00358 NA
111 hsa-miR-421 ALPK1 0.94 0 -0.31 0.03312 miRanda -0.21 0 NA
112 hsa-miR-421 AMACR 0.94 0 -0.65 0.0082 miRanda -0.25 0.00026 NA
113 hsa-miR-421 AMFR 0.94 0 -0.44 3.0E-5 miRanda -0.18 0 NA
114 hsa-miR-301a-3p AMOTL1 0.84 0 -0.53 0.02603 mirMAP -0.16 0.01497 NA
115 hsa-miR-182-5p AMT 1.97 0 -0.85 0 MirTarget -0.16 0 NA
116 hsa-miR-421 ANG 0.94 0 -1.78 0 miRanda -0.46 0 NA
117 hsa-miR-421 ANGPTL1 0.94 0 -2.91 0 miRanda -0.76 0 NA
118 hsa-miR-421 ANK3 0.94 0 -2.37 0 miRanda -0.17 0.04528 NA
119 hsa-miR-106b-5p ANKFY1 0.65 0 -0.58 0 miRNAWalker2 validate; MirTarget -0.24 0 NA
120 hsa-miR-132-3p ANKRD28 0.32 0.00272 -0.36 1.0E-5 miRNAWalker2 validate -0.15 2.0E-5 NA
121 hsa-miR-106b-5p ANKRD29 0.65 0 1.13 4.0E-5 MirTarget -0.64 0 NA
122 hsa-miR-106b-5p ANKRD50 0.65 0 -0.25 0.04433 MirTarget; miRNATAP -0.12 0.02751 NA
123 hsa-miR-421 ANO3 0.94 0 -2.3 0 miRanda -0.29 0.0085 NA
124 hsa-miR-106b-5p ANO6 0.65 0 -0.29 0.00464 MirTarget -0.14 0.00107 NA
125 hsa-miR-421 ANTXR1 0.94 0 -0.48 0.04009 miRanda -0.18 0.00652 NA
126 hsa-miR-940 ANTXR2 0.45 0.01771 -1.47 0 miRNATAP -0.16 4.0E-5 NA
127 hsa-miR-940 AOC3 0.45 0.01771 -0.85 0 MirTarget -0.14 5.0E-5 NA
128 hsa-miR-25-3p AP1AR 0.63 0 -0.61 0 MirTarget -0.18 0.00077 NA
129 hsa-miR-106b-5p AP1G1 0.65 0 -0.48 0 miRNAWalker2 validate -0.28 0 NA
130 hsa-miR-301a-3p AP1G1 0.84 0 -0.48 0 miRNATAP -0.19 0 NA
131 hsa-miR-421 AP1G1 0.94 0 -0.48 0 PITA; miRanda; mirMAP; miRNATAP -0.12 0 NA
132 hsa-miR-106b-5p AP3S2 0.65 0 -0.33 4.0E-5 mirMAP -0.2 0 NA
133 hsa-miR-25-3p AP3S2 0.63 0 -0.33 4.0E-5 mirMAP -0.13 0.00051 NA
134 hsa-miR-301a-3p AP3S2 0.84 0 -0.33 4.0E-5 mirMAP -0.17 0 NA
135 hsa-miR-106b-5p APBB2 0.65 0 -0.24 0.03085 MirTarget; miRNATAP -0.21 1.0E-5 NA
136 hsa-miR-301a-3p APBB2 0.84 0 -0.24 0.03085 mirMAP -0.13 1.0E-5 NA
137 hsa-miR-106b-5p APC 0.65 0 -0.18 0.06792 miRNAWalker2 validate; miRTarBase -0.15 0.00024 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells
138 hsa-miR-940 APLNR 0.45 0.01771 -0.98 9.0E-5 MirTarget -0.16 0.01343 NA
139 hsa-miR-27a-3p APOOL -0.37 0.00876 -0.42 0.00899 MirTarget -0.11 0.04681 NA
140 hsa-miR-27a-3p AQP11 -0.37 0.00876 -0.63 0.00064 MirTarget; miRNATAP -0.58 0 NA
141 hsa-miR-106b-5p AR 0.65 0 -2.66 0 mirMAP -1.42 0 NA
142 hsa-miR-132-3p AR 0.32 0.00272 -2.66 0 mirMAP -1.03 0 NA
143 hsa-miR-212-3p AR -0.29 0.10039 -2.66 0 mirMAP -0.44 0.00013 26553749 Aberrant coexpression of AR and hnRNPH1 and downregulation of miR-212 were detected in prostate tumors and correlate with disease progression in AA men compared with CA men; Ectopic expression of miR-212 mimics downregulated hnRNPH1 transcripts which in turn reduced expression of AR and its splice variant AR-V7 or AR3 in prostate cancer cells
144 hsa-miR-301a-3p AR 0.84 0 -2.66 0 mirMAP; miRNATAP -1.06 0 25940439 Mechanism dissection revealed infiltrating pre-adipocytes might function through down-regulation of the androgen receptor AR via modulation of miR-301a and then increase PCa cell invasion via induction of TGF-β1/Smad/MMP9 signals
145 hsa-miR-421 AR 0.94 0 -2.66 0 MirTarget; miRNATAP -0.67 0 26827675 A transcriptional target of androgen receptor miR 421 regulates proliferation and metabolism of prostate cancer cells; Expression of miR-421 was significantly suppressed by androgen treatment and correlated to AR expression in different prostate cancer cell lines; Furthermore androgen-activated AR could directly bind to androgen responsive element ARE of miR-421 as predicted by bioinformatics resources and demonstrated by ChIP and luciferase reporter assays
146 hsa-miR-301a-3p ARFIP1 0.84 0 -0.21 0.00812 miRNATAP -0.12 0 NA
147 hsa-miR-106b-5p ARHGAP23 0.65 0 -0.14 0.32985 mirMAP -0.31 0 NA
148 hsa-miR-106b-5p ARHGAP24 0.65 0 -0.99 0 MirTarget -0.32 3.0E-5 NA
149 hsa-miR-25-3p ARHGAP24 0.63 0 -0.99 0 MirTarget -0.36 3.0E-5 NA
150 hsa-miR-132-3p ARHGAP32 0.32 0.00272 -0.2 0.09921 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.19 0.00042 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 SMALL MOLECULE METABOLIC PROCESS 281 1767 9.502e-24 4.421e-20
2 RESPONSE TO ENDOGENOUS STIMULUS 235 1450 7.155e-21 1.665e-17
3 RESPONSE TO OXYGEN CONTAINING COMPOUND 222 1381 2.785e-19 4.32e-16
4 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 175 1008 1.201e-18 1.397e-15
5 ORGANIC ACID METABOLIC PROCESS 166 953 7.284e-18 6.779e-15
6 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 269 1848 2.656e-17 2.06e-14
7 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 245 1656 1.295e-16 7.969e-14
8 RESPONSE TO HORMONE 155 893 1.37e-16 7.969e-14
9 CELLULAR RESPONSE TO HORMONE STIMULUS 110 552 3.049e-16 1.577e-13
10 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 256 1805 4.447e-15 1.948e-12
11 INTRACELLULAR SIGNAL TRANSDUCTION 230 1572 4.604e-15 1.948e-12
12 POSITIVE REGULATION OF MOLECULAR FUNCTION 254 1791 5.854e-15 2.27e-12
13 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 273 1977 1.302e-14 4.661e-12
14 POSITIVE REGULATION OF GENE EXPRESSION 246 1733 1.532e-14 5.093e-12
15 CELLULAR CATABOLIC PROCESS 199 1322 2.542e-14 7.393e-12
16 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 137 799 2.415e-14 7.393e-12
17 REGULATION OF CELLULAR COMPONENT MOVEMENT 133 771 3.692e-14 1.011e-11
18 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 201 1360 1.163e-13 3.006e-11
19 ORGANONITROGEN COMPOUND METABOLIC PROCESS 248 1796 2.715e-13 6.648e-11
20 RESPONSE TO NITROGEN COMPOUND 141 859 3.287e-13 7.647e-11
21 NEGATIVE REGULATION OF CELL COMMUNICATION 178 1192 1.405e-12 3.113e-10
22 POSITIVE REGULATION OF CATABOLIC PROCESS 80 395 1.56e-12 3.3e-10
23 CATABOLIC PROCESS 242 1773 1.932e-12 3.908e-10
24 RESPONSE TO ORGANIC CYCLIC COMPOUND 145 917 2.826e-12 5.479e-10
25 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 210 1492 3.966e-12 7.381e-10
26 REGULATION OF CELL DIFFERENTIATION 209 1492 7.083e-12 1.268e-09
27 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 240 1784 1.092e-11 1.881e-09
28 RESPONSE TO LIPID 139 888 1.729e-11 2.873e-09
29 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 152 1004 2.476e-11 3.972e-09
30 REGULATION OF PHOSPHORUS METABOLIC PROCESS 220 1618 3.335e-11 5.172e-09
31 CELLULAR RESPONSE TO NITROGEN COMPOUND 91 505 4.245e-11 6.371e-09
32 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 82 437 4.993e-11 7.26e-09
33 HOMEOSTATIC PROCESS 188 1337 6.65e-11 9.163e-09
34 LIPID METABOLIC PROCESS 168 1158 6.695e-11 9.163e-09
35 SINGLE ORGANISM CATABOLIC PROCESS 145 957 6.945e-11 9.233e-09
36 OXIDATION REDUCTION PROCESS 138 898 7.658e-11 9.898e-09
37 RESPONSE TO PEPTIDE 77 404 9.034e-11 1.088e-08
38 CARBOXYLIC ACID CATABOLIC PROCESS 49 205 9.12e-11 1.088e-08
39 ORGANIC ACID CATABOLIC PROCESS 49 205 9.12e-11 1.088e-08
40 ORGANOPHOSPHATE METABOLIC PROCESS 136 885 1.061e-10 1.234e-08
41 COFACTOR METABOLIC PROCESS 67 334 1.578e-10 1.791e-08
42 POSITIVE REGULATION OF CATALYTIC ACTIVITY 206 1518 1.835e-10 1.985e-08
43 TISSUE DEVELOPMENT 206 1518 1.835e-10 1.985e-08
44 ORGANIC HYDROXY COMPOUND METABOLIC PROCESS 86 482 2.455e-10 2.596e-08
45 CELLULAR RESPONSE TO PEPTIDE 58 274 3.122e-10 3.182e-08
46 CARDIOVASCULAR SYSTEM DEVELOPMENT 123 788 3.214e-10 3.182e-08
47 CIRCULATORY SYSTEM DEVELOPMENT 123 788 3.214e-10 3.182e-08
48 REGULATION OF CATABOLIC PROCESS 116 731 3.83e-10 3.713e-08
49 REGULATION OF TRANSFERASE ACTIVITY 141 946 4.08e-10 3.874e-08
50 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 221 1672 4.175e-10 3.885e-08
51 REGULATION OF KINASE ACTIVITY 121 776 4.813e-10 4.392e-08
52 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 83 465 4.961e-10 4.412e-08
53 SMALL MOLECULE CATABOLIC PROCESS 65 328 5.026e-10 4.412e-08
54 REGULATION OF CELL DEATH 199 1472 5.381e-10 4.637e-08
55 REGULATION OF PROTEIN MODIFICATION PROCESS 224 1710 7.078e-10 5.988e-08
56 MONOCARBOXYLIC ACID METABOLIC PROCESS 87 503 9.621e-10 7.994e-08
57 REGULATION OF LIPID METABOLIC PROCESS 58 282 9.956e-10 8.127e-08
58 NEGATIVE REGULATION OF CELL DEATH 131 872 1.06e-09 8.507e-08
59 RESPONSE TO STEROID HORMONE 86 497 1.176e-09 9.274e-08
60 CHEMICAL HOMEOSTASIS 131 874 1.23e-09 9.538e-08
61 SULFUR COMPOUND METABOLIC PROCESS 68 359 1.489e-09 1.136e-07
62 CELL DEVELOPMENT 192 1426 1.564e-09 1.174e-07
63 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 91 541 1.7e-09 1.236e-07
64 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 91 541 1.7e-09 1.236e-07
65 CELLULAR RESPONSE TO LIPID 80 457 2.593e-09 1.857e-07
66 RESPONSE TO INSULIN 46 205 3.034e-09 2.139e-07
67 COENZYME METABOLIC PROCESS 54 265 5.263e-09 3.655e-07
68 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 134 926 7.601e-09 5.201e-07
69 POSITIVE REGULATION OF CELL COMMUNICATION 200 1532 8.623e-09 5.79e-07
70 REGULATION OF HYDROLASE ACTIVITY 178 1327 8.71e-09 5.79e-07
71 NEGATIVE REGULATION OF PHOSPHORYLATION 74 422 9.505e-09 6.229e-07
72 CELLULAR LIPID METABOLIC PROCESS 132 913 1.046e-08 6.757e-07
73 POSITIVE REGULATION OF RESPONSE TO STIMULUS 241 1929 1.177e-08 7.504e-07
74 REGULATION OF EPITHELIAL CELL MIGRATION 39 166 1.234e-08 7.759e-07
75 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 184 1395 1.7e-08 1.055e-06
76 CARBOHYDRATE DERIVATIVE METABOLIC PROCESS 146 1047 1.839e-08 1.116e-06
77 REGULATION OF TRANSPORT 227 1804 1.846e-08 1.116e-06
78 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 46 218 2.315e-08 1.38e-06
79 REGULATION OF CELL ADHESION 98 629 2.343e-08 1.38e-06
80 RESPONSE TO DRUG 74 431 2.374e-08 1.381e-06
81 REGULATION OF GTPASE ACTIVITY 103 673 2.62e-08 1.505e-06
82 RESPONSE TO ALCOHOL 65 362 2.976e-08 1.689e-06
83 ORGAN MORPHOGENESIS 122 841 3.187e-08 1.787e-06
84 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 142 1021 3.439e-08 1.905e-06
85 ALPHA AMINO ACID METABOLIC PROCESS 47 229 4.037e-08 2.159e-06
86 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 155 1142 4.003e-08 2.159e-06
87 REGULATION OF CELL PROLIFERATION 193 1496 3.982e-08 2.159e-06
88 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 195 1517 4.417e-08 2.336e-06
89 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 154 1135 4.536e-08 2.371e-06
90 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 104 689 4.606e-08 2.381e-06
91 ORGANONITROGEN COMPOUND CATABOLIC PROCESS 62 343 4.801e-08 2.455e-06
92 EPITHELIUM DEVELOPMENT 132 945 8.308e-08 4.171e-06
93 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 142 1036 8.476e-08 4.171e-06
94 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 142 1036 8.476e-08 4.171e-06
95 BLOOD VESSEL MORPHOGENESIS 64 364 8.516e-08 4.171e-06
96 CELL DEATH 138 1001 9.211e-08 4.464e-06
97 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 77 470 9.501e-08 4.558e-06
98 CELLULAR RESPONSE TO INSULIN STIMULUS 34 146 1.307e-07 6.205e-06
99 SECOND MESSENGER MEDIATED SIGNALING 36 160 1.423e-07 6.69e-06
100 RESPONSE TO EXTERNAL STIMULUS 224 1821 1.464e-07 6.814e-06
101 SMALL MOLECULE BIOSYNTHETIC PROCESS 73 443 1.613e-07 7.433e-06
102 REGULATION OF RESPONSE TO STRESS 187 1468 1.642e-07 7.463e-06
103 ENDOTHELIUM DEVELOPMENT 25 90 1.668e-07 7.463e-06
104 MONOCARBOXYLIC ACID CATABOLIC PROCESS 26 96 1.655e-07 7.463e-06
105 NUCLEOBASE CONTAINING SMALL MOLECULE METABOLIC PROCESS 84 535 1.69e-07 7.49e-06
106 POSITIVE REGULATION OF LOCOMOTION 70 420 1.854e-07 8.138e-06
107 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 146 1087 1.928e-07 8.384e-06
108 NEGATIVE REGULATION OF GENE EXPRESSION 189 1493 2.181e-07 9.397e-06
109 NEGATIVE REGULATION OF MOLECULAR FUNCTION 144 1079 3.437e-07 1.467e-05
110 STEROID HORMONE MEDIATED SIGNALING PATHWAY 30 125 3.517e-07 1.488e-05
111 WATER SOLUBLE VITAMIN METABOLIC PROCESS 24 88 4.252e-07 1.781e-05
112 POSITIVE REGULATION OF TRANSPORT 128 936 4.286e-07 1.781e-05
113 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 92 616 4.479e-07 1.844e-05
114 VITAMIN METABOLIC PROCESS 29 120 4.693e-07 1.915e-05
115 REGULATION OF CYTOPLASMIC TRANSPORT 76 481 5.058e-07 2.039e-05
116 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 36 168 5.082e-07 2.039e-05
117 REGULATION OF ENDOTHELIAL CELL MIGRATION 28 114 5.16e-07 2.052e-05
118 POSITIVE REGULATION OF KINASE ACTIVITY 76 482 5.495e-07 2.167e-05
119 REGULATION OF CELLULAR LOCALIZATION 164 1277 6.079e-07 2.377e-05
120 TUBE DEVELOPMENT 84 552 6.487e-07 2.515e-05
121 ENDOTHELIAL CELL DIFFERENTIATION 21 72 6.584e-07 2.532e-05
122 VASCULATURE DEVELOPMENT 74 469 7.528e-07 2.871e-05
123 LIPID HOMEOSTASIS 27 110 8.307e-07 3.143e-05
124 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 105 740 8.66e-07 3.249e-05
125 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 36 172 9.234e-07 3.437e-05
126 HORMONE MEDIATED SIGNALING PATHWAY 34 158 9.418e-07 3.478e-05
127 REGULATION OF PROTEIN LOCALIZATION 128 950 9.554e-07 3.5e-05
128 REGULATION OF ANATOMICAL STRUCTURE SIZE 74 472 9.636e-07 3.503e-05
129 REGULATION OF HOMEOSTATIC PROCESS 71 447 9.786e-07 3.53e-05
130 REGULATION OF OSTEOBLAST DIFFERENTIATION 27 112 1.215e-06 4.348e-05
131 REGULATION OF GLUCOSE METABOLIC PROCESS 26 106 1.338e-06 4.752e-05
132 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 111 801 1.35e-06 4.759e-05
133 FATTY ACID METABOLIC PROCESS 52 296 1.389e-06 4.86e-05
134 PHOSPHORYLATION 157 1228 1.403e-06 4.872e-05
135 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 51 289 1.524e-06 5.23e-05
136 SERINE FAMILY AMINO ACID METABOLIC PROCESS 15 42 1.529e-06 5.23e-05
137 EPITHELIAL CELL DIFFERENTIATION 76 495 1.561e-06 5.303e-05
138 REGULATION OF FATTY ACID OXIDATION 12 28 1.803e-06 6.081e-05
139 ANGIOGENESIS 51 293 2.31e-06 7.678e-05
140 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 40 208 2.3e-06 7.678e-05
141 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 118 876 2.594e-06 8.549e-05
142 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 25 103 2.609e-06 8.549e-05
143 RESPONSE TO ACID CHEMICAL 54 319 2.821e-06 9.114e-05
144 POSITIVE REGULATION OF HYDROLASE ACTIVITY 121 905 2.804e-06 9.114e-05
145 RESPONSE TO INORGANIC SUBSTANCE 73 479 3.284e-06 0.0001054
146 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 147 1152 3.439e-06 0.0001096
147 CENTRAL NERVOUS SYSTEM DEVELOPMENT 117 872 3.463e-06 0.0001096
148 FATTY ACID CATABOLIC PROCESS 20 73 3.548e-06 0.0001108
149 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 19 67 3.535e-06 0.0001108
150 NEUROGENESIS 173 1402 3.676e-06 0.000114
151 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 48 274 3.775e-06 0.0001163
152 CELLULAR RESPONSE TO ACID CHEMICAL 35 175 3.877e-06 0.0001179
153 NEURON DIFFERENTIATION 117 874 3.868e-06 0.0001179
154 CELLULAR AMINO ACID CATABOLIC PROCESS 26 112 4.036e-06 0.000122
155 RESPONSE TO ABIOTIC STIMULUS 133 1024 4.153e-06 0.0001247
156 REGULATION OF FAT CELL DIFFERENTIATION 25 106 4.544e-06 0.0001338
157 HEART DEVELOPMENT 71 466 4.501e-06 0.0001338
158 FAT CELL DIFFERENTIATION 25 106 4.544e-06 0.0001338
159 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 42 229 4.603e-06 0.0001347
160 SINGLE ORGANISM BIOSYNTHETIC PROCESS 166 1340 4.658e-06 0.0001355
161 NEURON DEVELOPMENT 96 687 4.925e-06 0.0001423
162 REGULATION OF FATTY ACID METABOLIC PROCESS 22 87 5.001e-06 0.0001436
163 LOCOMOTION 142 1114 5.372e-06 0.0001534
164 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 128 983 5.57e-06 0.000158
165 CARBOXYLIC ACID BIOSYNTHETIC PROCESS 47 270 5.66e-06 0.0001586
166 ORGANIC ACID BIOSYNTHETIC PROCESS 47 270 5.66e-06 0.0001586
167 NEGATIVE REGULATION OF CELL DIFFERENTIATION 87 609 5.729e-06 0.0001587
168 IRON ION HOMEOSTASIS 19 69 5.699e-06 0.0001587
169 REGULATION OF OSSIFICATION 35 178 5.771e-06 0.0001589
170 REGULATION OF CELL DEVELOPMENT 112 836 6.016e-06 0.0001647
171 EPITHELIAL CELL DEVELOPMENT 36 186 6.213e-06 0.0001674
172 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 46 263 6.224e-06 0.0001674
173 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 57 352 6.182e-06 0.0001674
174 POSITIVE REGULATION OF FATTY ACID OXIDATION 8 14 6.953e-06 0.0001859
175 REGULATION OF INTRACELLULAR TRANSPORT 88 621 7.005e-06 0.0001863
176 REGULATION OF SYSTEM PROCESS 75 507 7.265e-06 0.0001921
177 REGULATION OF RESPONSE TO WOUNDING 64 413 7.548e-06 0.0001984
178 CELLULAR LIPID CATABOLIC PROCESS 31 151 7.79e-06 0.0002036
179 REGULATION OF CELLULAR KETONE METABOLIC PROCESS 34 173 7.887e-06 0.0002036
180 REGULATION OF CELL SUBSTRATE ADHESION 34 173 7.887e-06 0.0002036
181 REGULATION OF CELLULAR PROTEIN LOCALIZATION 80 552 7.922e-06 0.0002036
182 POST GOLGI VESICLE MEDIATED TRANSPORT 21 83 8.074e-06 0.0002059
183 POSITIVE REGULATION OF CELL DIFFERENTIATION 110 823 8.099e-06 0.0002059
184 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 60 381 8.697e-06 0.0002199
185 CELLULAR AMINO ACID METABOLIC PROCESS 54 332 9.424e-06 0.000237
186 TELENCEPHALON DEVELOPMENT 41 228 9.791e-06 0.0002449
187 CELLULAR ALDEHYDE METABOLIC PROCESS 21 84 9.874e-06 0.0002457
188 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 31 153 1.03e-05 0.000255
189 REGULATION OF TRANSPORTER ACTIVITY 37 198 1.073e-05 0.0002629
190 HEAD DEVELOPMENT 97 709 1.073e-05 0.0002629
191 KIDNEY EPITHELIUM DEVELOPMENT 27 125 1.114e-05 0.0002715
192 ORGANIC HYDROXY COMPOUND CATABOLIC PROCESS 19 72 1.121e-05 0.0002716
193 GROWTH 63 410 1.165e-05 0.0002808
194 CELLULAR RESPONSE TO OXIDATIVE STRESS 35 184 1.233e-05 0.0002958
195 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 47 278 1.256e-05 0.0002998
196 RESPONSE TO OXIDATIVE STRESS 56 352 1.266e-05 0.0003007
197 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 28 133 1.287e-05 0.000304
198 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 73 498 1.318e-05 0.0003098
199 NEGATIVE REGULATION OF LOCOMOTION 45 263 1.396e-05 0.0003264
200 TRANSITION METAL ION HOMEOSTASIS 24 106 1.468e-05 0.0003416
201 COENZYME BIOSYNTHETIC PROCESS 27 127 1.514e-05 0.0003504
202 CELLULAR AMINO ACID BIOSYNTHETIC PROCESS 22 93 1.584e-05 0.0003648
203 REGULATION OF NEURON DIFFERENTIATION 79 554 1.628e-05 0.0003732
204 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 41 233 1.676e-05 0.0003822
205 RESPONSE TO EXTRACELLULAR STIMULUS 66 441 1.736e-05 0.000394
206 ORGAN GROWTH 18 68 1.81e-05 0.0004088
207 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 109 829 1.831e-05 0.0004095
208 ALCOHOL METABOLIC PROCESS 55 348 1.828e-05 0.0004095
209 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 17 62 1.861e-05 0.0004142
210 NEGATIVE REGULATION OF KINASE ACTIVITY 43 250 1.882e-05 0.000417
211 ER NUCLEUS SIGNALING PATHWAY 12 34 1.964e-05 0.000431
212 UROGENITAL SYSTEM DEVELOPMENT 49 299 1.955e-05 0.000431
213 CIRCULATORY SYSTEM PROCESS 57 366 2.012e-05 0.0004376
214 PROTEIN UBIQUITINATION 87 629 2.009e-05 0.0004376
215 POSITIVE REGULATION OF AUTOPHAGY 19 75 2.11e-05 0.0004566
216 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 39 220 2.239e-05 0.0004823
217 RESPONSE TO LEPTIN 9 20 2.263e-05 0.0004853
218 REGULATION OF JNK CASCADE 31 159 2.294e-05 0.0004897
219 REGULATION OF MUSCLE ADAPTATION 17 63 2.34e-05 0.0004971
220 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORT 25 116 2.42e-05 0.0005072
221 RESPONSE TO KETONE 34 182 2.418e-05 0.0005072
222 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 30 152 2.419e-05 0.0005072
223 PURINE CONTAINING COMPOUND METABOLIC PROCESS 60 394 2.449e-05 0.0005109
224 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 122 957 2.489e-05 0.000517
225 REGULATION OF MAPK CASCADE 90 660 2.514e-05 0.0005177
226 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 97 724 2.511e-05 0.0005177
227 PROTEIN CATABOLIC PROCESS 81 579 2.565e-05 0.0005234
228 ORGANONITROGEN COMPOUND BIOSYNTHETIC PROCESS 129 1024 2.563e-05 0.0005234
229 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 28 138 2.637e-05 0.0005359
230 REGULATION OF MAP KINASE ACTIVITY 51 319 2.653e-05 0.0005367
231 NEGATIVE REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 27 131 2.723e-05 0.0005462
232 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 85 616 2.722e-05 0.0005462
233 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 18 70 2.777e-05 0.0005546
234 CYCLIC NUCLEOTIDE MEDIATED SIGNALING 14 46 2.794e-05 0.0005557
235 RESPONSE TO REACTIVE OXYGEN SPECIES 35 191 2.826e-05 0.0005595
236 AMMONIUM ION METABOLIC PROCESS 32 169 3.14e-05 0.0006191
237 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 13 41 3.314e-05 0.0006505
238 CELLULAR RESPONSE TO STRESS 184 1565 3.348e-05 0.0006545
239 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 73 513 3.617e-05 0.0007042
240 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 56 365 3.645e-05 0.0007067
241 ION HOMEOSTASIS 80 576 3.705e-05 0.0007153
242 REGULATION OF VASCULATURE DEVELOPMENT 40 233 3.785e-05 0.0007278
243 RESPONSE TO XENOBIOTIC STIMULUS 23 105 3.846e-05 0.0007365
244 TISSUE MORPHOGENESIS 75 533 4.157e-05 0.0007895
245 RESPONSE TO ESTROGEN 38 218 4.157e-05 0.0007895
246 DEVELOPMENTAL GROWTH 52 333 4.242e-05 0.0008024
247 REGULATION OF MUSCLE SYSTEM PROCESS 35 195 4.423e-05 0.0008332
248 NEGATIVE REGULATION OF CELL PROLIFERATION 87 643 4.549e-05 0.0008535
249 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 20 86 4.928e-05 0.0009208
250 RESPONSE TO WOUNDING 78 563 5.023e-05 0.0009282
251 NEURON PROJECTION DEVELOPMENT 76 545 5.023e-05 0.0009282
252 GLAND DEVELOPMENT 59 395 5.027e-05 0.0009282
253 ENDOMEMBRANE SYSTEM ORGANIZATION 67 465 5.067e-05 0.000932
254 PROTEIN PHOSPHORYLATION 119 944 5.126e-05 0.000939
255 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 22 100 5.243e-05 0.0009566
256 COFACTOR BIOSYNTHETIC PROCESS 31 166 5.455e-05 0.0009914
257 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 35 197 5.497e-05 0.0009952
258 RESPONSE TO OXYGEN LEVELS 49 311 5.535e-05 0.0009983
259 STEROID METABOLIC PROCESS 40 237 5.611e-05 0.001008
260 REGULATION OF MUSCLE CELL APOPTOTIC PROCESS 13 43 5.813e-05 0.001036
261 CHONDROITIN SULFATE PROTEOGLYCAN METABOLIC PROCESS 13 43 5.813e-05 0.001036
262 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 65 450 6.047e-05 0.001062
263 REGULATION OF ACTIN FILAMENT BASED PROCESS 49 312 6.013e-05 0.001062
264 GOLGI TO VACUOLE TRANSPORT 10 27 6.049e-05 0.001062
265 CELLULAR RESPONSE TO ALCOHOL 24 115 6.041e-05 0.001062
266 DICARBOXYLIC ACID METABOLIC PROCESS 22 101 6.149e-05 0.001076
267 GLYCEROLIPID METABOLIC PROCESS 54 356 6.798e-05 0.001184
268 PROTEIN LOCALIZATION 206 1805 6.822e-05 0.001184
269 POSITIVE REGULATION OF CELL DEATH 82 605 7.025e-05 0.001215
270 LIPID LOCALIZATION 43 264 7.102e-05 0.001224
271 RESPONSE TO HYDROGEN PEROXIDE 23 109 7.132e-05 0.001224
272 REGULATION OF BODY FLUID LEVELS 71 506 7.213e-05 0.001234
273 BEHAVIOR 72 516 7.692e-05 0.001311
274 RESPONSE TO STARVATION 29 154 8.008e-05 0.00136
275 REGULATION OF PROTEIN CATABOLIC PROCESS 58 393 8.141e-05 0.001377
276 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 152 1275 8.546e-05 0.001441
277 REGULATION OF METAL ION TRANSPORT 50 325 8.673e-05 0.001452
278 GLYOXYLATE METABOLIC PROCESS 10 28 8.665e-05 0.001452
279 AUTOPHAGY 58 394 8.74e-05 0.001458
280 MUSCLE TISSUE DEVELOPMENT 44 275 9.022e-05 0.001499
281 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 12 39 9.216e-05 0.001526
282 PROTEOGLYCAN METABOLIC PROCESS 19 83 9.464e-05 0.001551
283 RESPONSE TO FATTY ACID 19 83 9.464e-05 0.001551
284 REGULATION OF ION TRANSPORT 80 592 9.47e-05 0.001551
285 CELL MOTILITY 106 835 9.949e-05 0.001617
286 LOCALIZATION OF CELL 106 835 9.949e-05 0.001617
287 LIPID OXIDATION 17 70 0.0001001 0.001617
288 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 17 70 0.0001001 0.001617
289 REGULATION OF WOUND HEALING 25 126 0.000102 0.001636
290 NEGATIVE REGULATION OF RESPONSE TO WOUNDING 29 156 0.0001017 0.001636
291 SULFUR COMPOUND BIOSYNTHETIC PROCESS 35 203 0.0001028 0.001639
292 REGULATION OF NUCLEOTIDE METABOLIC PROCESS 36 211 0.0001028 0.001639
293 REGULATION OF EPITHELIAL CELL PROLIFERATION 45 285 0.0001038 0.001648
294 RESPONSE TO FLUID SHEAR STRESS 11 34 0.0001085 0.001717
295 REGULATION OF CELL PROJECTION ORGANIZATION 76 558 0.0001091 0.00172
296 ION TRANSPORT 150 1262 0.0001099 0.001728
297 POSITIVE REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 21 98 0.0001148 0.001798
298 CELLULAR RESPONSE TO FLUID SHEAR STRESS 8 19 0.0001167 0.001822
299 REGULATION OF HORMONE LEVELS 67 478 0.0001175 0.001829
300 MACROMOLECULE CATABOLIC PROCESS 115 926 0.0001268 0.001966
301 RESPONSE TO PURINE CONTAINING COMPOUND 29 158 0.0001284 0.001984
302 REGULATION OF CELL MORPHOGENESIS 75 552 0.0001304 0.002009
303 REGULATION OF LIPID BIOSYNTHETIC PROCESS 25 128 0.0001327 0.002032
304 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 25 128 0.0001327 0.002032
305 REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 16 65 0.000134 0.002044
306 FOREBRAIN DEVELOPMENT 53 357 0.0001388 0.002111
307 POSITIVE REGULATION OF CELL PROLIFERATION 103 814 0.0001406 0.002132
308 RESPONSE TO ETHANOL 26 136 0.0001419 0.002142
309 REGULATION OF CELLULAR COMPONENT BIOGENESIS 98 767 0.0001423 0.002142
310 CELLULAR COMPONENT MORPHOGENESIS 112 900 0.0001428 0.002143
311 TUBE MORPHOGENESIS 49 323 0.0001439 0.002153
312 AGING 42 264 0.0001465 0.002186
313 POSITIVE REGULATION OF CELL CYCLE 50 332 0.0001485 0.002207
314 REGULATION OF PEPTIDE TRANSPORT 41 256 0.0001507 0.002234
315 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 109 873 0.0001537 0.00227
316 CELLULAR RESPONSE TO TOPOLOGICALLY INCORRECT PROTEIN 24 122 0.0001597 0.002349
317 RESPONSE TO METAL ION 50 333 0.00016 0.002349
318 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 38 232 0.0001616 0.002365
319 NEGATIVE REGULATION OF MUSCLE CELL APOPTOTIC PROCESS 10 30 0.0001682 0.002446
320 RESPONSE TO CYTOKINE 92 714 0.0001678 0.002446
321 REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 22 108 0.0001746 0.00253
322 REGULATION OF GLUCOSE IMPORT 15 60 0.0001787 0.002582
323 NEGATIVE REGULATION OF LIPID METABOLIC PROCESS 18 80 0.0001809 0.002605
324 REGULATION OF VOLTAGE GATED CALCIUM CHANNEL ACTIVITY 9 25 0.0001829 0.002626
325 REGULATION OF CARBOHYDRATE BIOSYNTHETIC PROCESS 19 87 0.0001837 0.00263
326 CARBOHYDRATE DERIVATIVE BIOSYNTHETIC PROCESS 79 595 0.0001854 0.002647
327 RESPONSE TO ESTRADIOL 27 146 0.0001897 0.002694
328 MUSCLE STRUCTURE DEVELOPMENT 61 432 0.0001899 0.002694
329 ACTIN FILAMENT BASED PROCESS 63 450 0.0001915 0.002708
330 REGULATION OF NUCLEOTIDE CATABOLIC PROCESS 11 36 0.000193 0.002713
331 POSITIVE REGULATION OF GLUCOSE METABOLIC PROCESS 11 36 0.000193 0.002713
332 CATECHOLAMINE METABOLIC PROCESS 12 42 0.0002029 0.002835
333 CATECHOL CONTAINING COMPOUND METABOLIC PROCESS 12 42 0.0002029 0.002835
334 CONNECTIVE TISSUE DEVELOPMENT 33 194 0.0002074 0.00289
335 ALPHA AMINO ACID CATABOLIC PROCESS 20 95 0.0002129 0.002957
336 REGULATION OF JUN KINASE ACTIVITY 18 81 0.0002135 0.002957
337 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 50 337 0.0002146 0.002961
338 REGULATION OF CATION CHANNEL ACTIVITY 19 88 0.0002151 0.002961
339 CELLULAR RESPONSE TO HYDROGEN PEROXIDE 15 61 0.0002178 0.002989
340 REGULATION OF CELL CYCLE 116 949 0.0002247 0.003066
341 RESPONSE TO TOPOLOGICALLY INCORRECT PROTEIN 29 163 0.0002244 0.003066
342 REGULATION OF NEURON PROJECTION DEVELOPMENT 58 408 0.0002259 0.003073
343 POSITIVE REGULATION OF ION TRANSPORT 38 236 0.000231 0.003134
344 SERINE FAMILY AMINO ACID BIOSYNTHETIC PROCESS 7 16 0.0002379 0.003199
345 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 37 228 0.0002367 0.003199
346 CELLULAR RESPONSE TO LEPTIN STIMULUS 7 16 0.0002379 0.003199
347 DIGESTIVE SYSTEM DEVELOPMENT 27 148 0.000239 0.003205
348 CELLULAR MODIFIED AMINO ACID METABOLIC PROCESS 36 220 0.0002417 0.003232
349 POSITIVE REGULATION OF CATION CHANNEL ACTIVITY 11 37 0.0002528 0.003332
350 REGULATION OF CELL SIZE 30 172 0.0002527 0.003332
351 REGULATION OF MUSCLE HYPERTROPHY 11 37 0.0002528 0.003332
352 REGULATION OF GENERATION OF PRECURSOR METABOLITES AND ENERGY 19 89 0.000251 0.003332
353 CAMP MEDIATED SIGNALING 11 37 0.0002528 0.003332
354 TEMPERATURE HOMEOSTASIS 9 26 0.0002578 0.003389
355 RESPONSE TO COLD 12 43 0.0002589 0.003394
356 SINGLE ORGANISM BEHAVIOR 55 384 0.0002677 0.003499
357 CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES 21 104 0.0002756 0.003592
358 POSITIVE REGULATION OF CELL ADHESION 54 376 0.0002831 0.003679
359 CALCIUM MEDIATED SIGNALING 19 90 0.0002921 0.003755
360 RESPONSE TO GROWTH FACTOR 65 475 0.000292 0.003755
361 LIPID CATABOLIC PROCESS 39 247 0.0002904 0.003755
362 MESONEPHROS DEVELOPMENT 19 90 0.0002921 0.003755
363 ORGAN REGENERATION 18 83 0.0002946 0.003776
364 POSITIVE REGULATION OF BINDING 24 127 0.0003012 0.00384
365 REGULATION OF PROTEIN TARGETING 46 307 0.0003007 0.00384
366 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 51 351 0.0003114 0.003959
367 POSITIVE REGULATION OF JUN KINASE ACTIVITY 15 63 0.0003184 0.004026
368 NEGATIVE REGULATION OF NUCLEOTIDE METABOLIC PROCESS 15 63 0.0003184 0.004026
369 CELLULAR RESPONSE TO OXYGEN LEVELS 26 143 0.0003262 0.004114
370 REGULATION OF SODIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 11 38 0.0003275 0.004118
371 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 34 207 0.0003301 0.004129
372 POSITIVE REGULATION OF MAP KINASE ACTIVITY 34 207 0.0003301 0.004129
373 REGULATION OF CELLULAR RESPONSE TO STRESS 88 691 0.0003407 0.00425
374 ACTOMYOSIN STRUCTURE ORGANIZATION 17 77 0.0003436 0.004275
375 GENERATION OF PRECURSOR METABOLITES AND ENERGY 44 292 0.0003552 0.004407
376 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 23 121 0.0003651 0.004518
377 POSITIVE REGULATION OF MAPK CASCADE 64 470 0.0003704 0.004542
378 WOUND HEALING 64 470 0.0003704 0.004542
379 REGULATION OF PROTEIN SECRETION 55 389 0.000371 0.004542
380 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 33 200 0.0003683 0.004542
381 REGULATION OF WNT SIGNALING PATHWAY 46 310 0.0003748 0.004577
382 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 31 184 0.0003776 0.004599
383 REGULATION OF ANDROGEN RECEPTOR SIGNALING PATHWAY 8 22 0.0003876 0.004625
384 ENERGY DERIVATION BY OXIDATION OF ORGANIC COMPOUNDS 35 217 0.0003867 0.004625
385 POSITIVE REGULATION OF MUSCLE HYPERTROPHY 8 22 0.0003876 0.004625
386 CELLULAR RESPONSE TO FATTY ACID 13 51 0.000387 0.004625
387 POSITIVE REGULATION OF CARDIAC MUSCLE HYPERTROPHY 8 22 0.0003876 0.004625
388 CELLULAR RESPONSE TO INTERLEUKIN 6 8 22 0.0003876 0.004625
389 REGULATION OF STRIATED MUSCLE CELL APOPTOTIC PROCESS 8 22 0.0003876 0.004625
390 REGULATION OF APOPTOTIC SIGNALING PATHWAY 52 363 0.0003864 0.004625
391 REGULATION OF CELLULAR COMPONENT SIZE 49 337 0.0003976 0.004731
392 NEUTRAL LIPID METABOLIC PROCESS 18 85 0.0004011 0.004761
393 BIOLOGICAL ADHESION 123 1032 0.0004081 0.004832
394 ENDOTHELIAL CELL DEVELOPMENT 12 45 0.000411 0.004854
395 PALLIUM DEVELOPMENT 27 153 0.0004152 0.004891
396 TRABECULA MORPHOGENESIS 11 39 0.0004199 0.004934
397 REGULATION OF HEART RATE 18 86 0.0004659 0.00546
398 REGULATION OF LIPID CATABOLIC PROCESS 13 52 0.0004746 0.005548
399 NEURON PROJECTION MORPHOGENESIS 56 402 0.0004789 0.005572
400 NEGATIVE REGULATION OF FATTY ACID BIOSYNTHETIC PROCESS 6 13 0.000479 0.005572
401 MUSCLE CELL DIFFERENTIATION 37 237 0.0005113 0.005933
402 CARBOHYDRATE METABOLIC PROCESS 84 662 0.0005158 0.00597
403 POSITIVE REGULATION OF NEURON DIFFERENTIATION 45 306 0.0005251 0.006063
404 CAMP METABOLIC PROCESS 10 34 0.0005286 0.006088
405 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 56 404 0.0005415 0.006221
406 CELLULAR RESPONSE TO KETONE 16 73 0.0005533 0.006341
407 PHOSPHATIDYLETHANOLAMINE METABOLIC PROCESS 7 18 0.0005646 0.006439
408 AMINO ACID BETAINE METABOLIC PROCESS 7 18 0.0005646 0.006439
409 BONE DEVELOPMENT 27 156 0.0005687 0.006454
410 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 20 102 0.0005681 0.006454
411 REGULATION OF NITRIC OXIDE BIOSYNTHETIC PROCESS 13 53 0.0005784 0.006548
412 REGULATION OF COAGULATION 18 88 0.0006229 0.007001
413 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 18 88 0.0006229 0.007001
414 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 14 60 0.0006213 0.007001
415 CELLULAR HOMEOSTASIS 85 676 0.0006366 0.007137
416 NEGATIVE REGULATION OF CELL ADHESION 35 223 0.0006467 0.007233
417 RESPONSE TO MONOAMINE 10 35 0.0006818 0.007606
418 REGULATION OF TRANSMEMBRANE TRANSPORT 58 426 0.0006833 0.007606
419 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 28 166 0.0006933 0.007699
420 MONOSACCHARIDE TRANSPORT 13 54 0.0007008 0.007764
421 RESPONSE TO CAMP 20 104 0.0007358 0.008113
422 REGULATION OF CELL GROWTH 54 391 0.0007346 0.008113
423 REGULATION OF PROTEIN IMPORT 30 183 0.0007413 0.008155
424 SKELETAL SYSTEM DEVELOPMENT 61 455 0.0007489 0.008218
425 ORGANIC HYDROXY COMPOUND BIOSYNTHETIC PROCESS 29 175 0.0007542 0.008257
426 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 15 68 0.0007589 0.008289
427 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 12 48 0.0007759 0.008338
428 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 14 0.0007755 0.008338
429 RAS PROTEIN SIGNAL TRANSDUCTION 25 143 0.000768 0.008338
430 PHOSPHATIDYLETHANOLAMINE BIOSYNTHETIC PROCESS 6 14 0.0007755 0.008338
431 POSITIVE REGULATION OF CELL SIZE 6 14 0.0007755 0.008338
432 REGULATION OF SODIUM ION TRANSMEMBRANE TRANSPORT 12 48 0.0007759 0.008338
433 RESPONSE TO LAMINAR FLUID SHEAR STRESS 6 14 0.0007755 0.008338
434 REGULATION OF DENDRITE DEVELOPMENT 22 120 0.0008081 0.008664
435 REGULATION OF PEPTIDE SECRETION 33 209 0.0008171 0.00874
436 SODIUM ION TRANSMEMBRANE TRANSPORT 18 90 0.0008235 0.008753
437 EMBRYO DEVELOPMENT 107 894 0.0008242 0.008753
438 ASPARTATE FAMILY AMINO ACID CATABOLIC PROCESS 7 19 0.0008258 0.008753
439 GOLGI TO ENDOSOME TRANSPORT 7 19 0.0008258 0.008753
440 REGULATION OF CELLULAR CARBOHYDRATE CATABOLIC PROCESS 11 42 0.0008372 0.008833
441 REGULATION OF CARBOHYDRATE CATABOLIC PROCESS 11 42 0.0008372 0.008833
442 ASPARTATE FAMILY AMINO ACID METABOLIC PROCESS 13 55 0.0008442 0.008887
443 THIOESTER METABOLIC PROCESS 17 83 0.0008581 0.008893
444 NEGATIVE REGULATION OF INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY 9 30 0.0008527 0.008893
445 RESPONSE TO GROWTH HORMONE 9 30 0.0008527 0.008893
446 NEGATIVE REGULATION OF TOR SIGNALING 9 30 0.0008527 0.008893
447 REGULATION OF NEURON DEATH 38 252 0.0008528 0.008893
448 ACYL COA METABOLIC PROCESS 17 83 0.0008581 0.008893
449 REGULATION OF POTASSIUM ION TRANSPORT 17 83 0.0008581 0.008893
450 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 92 750 0.0008695 0.008991
451 ORGANOPHOSPHATE CATABOLIC PROCESS 21 113 0.0008758 0.009036
452 REGULATION OF CALCIUM MEDIATED SIGNALING 16 76 0.0008822 0.009062
453 IMMUNE SYSTEM PROCESS 215 1984 0.0008807 0.009062
454 RESPONSE TO MECHANICAL STIMULUS 33 210 0.0008888 0.009109
455 NUCLEOSIDE PHOSPHATE CATABOLIC PROCESS 15 69 0.0008915 0.009117
456 REGULATION OF MITOTIC CELL CYCLE 62 468 0.0009223 0.009411
457 NEGATIVE REGULATION OF GROWTH 36 236 0.000931 0.009479
458 REGULATION OF NUCLEOSIDE METABOLIC PROCESS 12 49 0.0009458 0.009555
459 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 26 153 0.0009436 0.009555
460 REGULATION OF ATP METABOLIC PROCESS 12 49 0.0009458 0.009555
461 CELLULAR MACROMOLECULE LOCALIZATION 141 1234 0.0009467 0.009555
462 PROTEASOMAL PROTEIN CATABOLIC PROCESS 40 271 0.0009672 0.009741
463 POSITIVE REGULATION OF OSSIFICATION 17 84 0.0009885 0.009934
464 ORGANIC ANION TRANSPORT 53 387 0.0009933 0.00996
465 WNT SIGNALING PATHWAY 49 351 0.0009967 0.009974
466 PLASMA MEMBRANE ORGANIZATION 32 203 0.0009994 0.009979
NumGOOverlapSizeP ValueAdj. P Value
1 ENZYME BINDING 249 1737 3.229e-15 1.922e-12
2 COFACTOR BINDING 66 263 4.137e-15 1.922e-12
3 COENZYME BINDING 44 179 3.151e-10 9.758e-08
4 TRANSCRIPTION FACTOR BINDING 90 524 7.114e-10 1.652e-07
5 OXIDOREDUCTASE ACTIVITY 113 719 1.158e-09 2.151e-07
6 MOLECULAR FUNCTION REGULATOR 177 1353 5.857e-08 9.068e-06
7 STEROID HORMONE RECEPTOR ACTIVITY 20 59 7.74e-08 1.027e-05
8 IDENTICAL PROTEIN BINDING 160 1209 1.272e-07 1.477e-05
9 CYTOSKELETAL PROTEIN BINDING 116 819 2.523e-07 2.344e-05
10 TRANSITION METAL ION BINDING 179 1400 2.411e-07 2.344e-05
11 TRANSCRIPTION FACTOR ACTIVITY DIRECT LIGAND REGULATED SEQUENCE SPECIFIC DNA BINDING 17 48 3.545e-07 2.745e-05
12 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 94 629 3.264e-07 2.745e-05
13 PROTEIN HOMODIMERIZATION ACTIVITY 104 722 4.764e-07 3.161e-05
14 UBIQUITIN LIKE PROTEIN CONJUGATING ENZYME BINDING 14 34 4.488e-07 3.161e-05
15 SULFUR COMPOUND BINDING 45 234 5.508e-07 3.411e-05
16 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 57 328 6.342e-07 3.682e-05
17 UBIQUITIN LIKE PROTEIN TRANSFERASE ACTIVITY 68 420 8.209e-07 4.486e-05
18 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 26 104 9.044e-07 4.668e-05
19 ZINC ION BINDING 150 1155 9.906e-07 4.843e-05
20 KINASE ACTIVITY 115 842 1.784e-06 8.287e-05
21 PROTEIN DIMERIZATION ACTIVITY 147 1149 2.977e-06 0.0001317
22 FLAVIN ADENINE DINUCLEOTIDE BINDING 20 74 4.46e-06 0.0001801
23 LIGASE ACTIVITY 64 406 4.274e-06 0.0001801
24 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 52 315 8.944e-06 0.0003462
25 TRANSCRIPTION COACTIVATOR BINDING 7 11 1.023e-05 0.0003791
26 RECEPTOR BINDING 178 1476 1.061e-05 0.0003791
27 ACTIN BINDING 61 393 1.163e-05 4e-04
28 LIPID BINDING 91 657 1.233e-05 0.000409
29 RIBONUCLEOTIDE BINDING 216 1860 1.477e-05 0.0004619
30 OXIDOREDUCTASE ACTIVITY ACTING ON CH OH GROUP OF DONORS 28 134 1.492e-05 0.0004619
31 ORGANIC ACID BINDING 38 209 1.575e-05 0.0004721
32 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 40 226 1.837e-05 0.0005334
33 ADENYL NUCLEOTIDE BINDING 180 1514 2.176e-05 0.0005946
34 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 126 992 2.175e-05 0.0005946
35 TRANSLATION REPRESSOR ACTIVITY 9 20 2.263e-05 0.0006007
36 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 49 303 2.793e-05 0.0007013
37 ENZYME REGULATOR ACTIVITY 122 959 2.737e-05 0.0007013
38 UBIQUITIN LIKE PROTEIN LIGASE ACTIVITY 36 199 2.913e-05 0.0007122
39 STEROID BINDING 21 91 3.645e-05 0.0008682
40 FATTY ACYL COA BINDING 11 31 4.119e-05 0.0009567
41 KINASE BINDING 83 606 4.4e-05 0.0009969
42 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 39 228 5.107e-05 0.00113
43 PROTEIN KINASE ACTIVITY 86 640 6.425e-05 0.001388
44 NADP BINDING 13 44 7.586e-05 0.001602
45 HISTONE ACETYLTRANSFERASE BINDING 10 28 8.665e-05 0.001789
46 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 144 1199 9.318e-05 0.001882
47 REGULATORY REGION NUCLEIC ACID BINDING 104 818 0.0001089 0.002064
48 E BOX BINDING 11 34 0.0001085 0.002064
49 MACROMOLECULAR COMPLEX BINDING 164 1399 0.0001062 0.002064
50 OXIDOREDUCTASE ACTIVITY ACTING ON THE CH OH GROUP OF DONORS NAD OR NADP AS ACCEPTOR 23 113 0.0001272 0.002318
51 TRANSCRIPTION COFACTOR BINDING 9 24 0.000127 0.002318
52 MONOCARBOXYLIC ACID BINDING 16 65 0.000134 0.002394
53 CHAPERONE BINDING 18 81 0.0002135 0.003743
54 RECEPTOR SIGNALING PROTEIN ACTIVITY 30 172 0.0002527 0.004348
55 GLYCOSAMINOGLYCAN BINDING 34 205 0.0002742 0.004632
56 PYRIDOXAL PHOSPHATE BINDING 13 52 0.0004746 0.007873
57 PROTEIN DOMAIN SPECIFIC BINDING 80 624 0.0005082 0.008196
58 OXIDOREDUCTASE ACTIVITY ACTING ON THE ALDEHYDE OR OXO GROUP OF DONORS 12 46 0.0005117 0.008196
59 CAMP BINDING 8 23 0.0005484 0.008491
60 TRANSFERASE ACTIVITY TRANSFERRING NITROGENOUS GROUPS 8 23 0.0005484 0.008491
61 UBIQUITIN LIKE PROTEIN LIGASE BINDING 40 264 0.0005751 0.008759
62 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 17 81 0.0006408 0.009602
NumGOOverlapSizeP ValueAdj. P Value
1 ENDOPLASMIC RETICULUM 225 1631 4.603e-12 2.688e-09
2 MEMBRANE REGION 165 1134 8.004e-11 2.337e-08
3 VACUOLE 165 1180 1.655e-09 3.222e-07
4 MITOCHONDRION 212 1633 4.634e-09 6.766e-07
5 BASAL PLASMA MEMBRANE 15 33 3.467e-08 2.531e-06
6 NUCLEAR OUTER MEMBRANE ENDOPLASMIC RETICULUM MEMBRANE NETWORK 141 1005 2.231e-08 2.531e-06
7 GOLGI APPARATUS 188 1445 3.274e-08 2.531e-06
8 BASAL PART OF CELL 19 51 2.823e-08 2.531e-06
9 ENDOPLASMIC RETICULUM PART 157 1163 4.65e-08 3.017e-06
10 PLASMA MEMBRANE REGION 130 929 9.42e-08 5.501e-06
11 MEMBRANE MICRODOMAIN 53 288 2.467e-07 1.31e-05
12 ENDOSOME 112 793 4.707e-07 2.291e-05
13 CYTOPLASMIC REGION 52 287 5.266e-07 2.366e-05
14 NEURON PROJECTION 128 942 6.067e-07 2.531e-05
15 NEURON PART 162 1265 8.516e-07 3.316e-05
16 MITOCHONDRIAL PART 125 953 5.026e-06 0.0001824
17 CELL CORTEX 43 238 5.309e-06 0.0001824
18 APICAL PART OF CELL 58 361 6.58e-06 0.0002135
19 PERINUCLEAR REGION OF CYTOPLASM 90 642 8.531e-06 0.0002622
20 PROTEIN KINASE COMPLEX 22 90 9.042e-06 0.000264
21 ACTIN CYTOSKELETON 67 444 1.144e-05 0.0003181
22 SOMATODENDRITIC COMPARTMENT 90 650 1.393e-05 0.0003697
23 PLASMA MEMBRANE RAFT 21 86 1.46e-05 0.0003707
24 CELL CORTEX PART 25 119 3.81e-05 0.0008559
25 CELL PROJECTION 206 1786 3.616e-05 0.0008559
26 ENVELOPE 135 1090 3.774e-05 0.0008559
27 CYCLIN DEPENDENT PROTEIN KINASE HOLOENZYME COMPLEX 11 31 4.119e-05 0.000891
28 UBIQUITIN LIGASE COMPLEX 43 262 5.929e-05 0.001237
29 SYNAPSE 98 754 7.501e-05 0.001511
30 CELL LEADING EDGE 53 350 8.266e-05 0.001609
31 AXON PART 37 219 0.0001024 0.001929
32 MICROBODY 26 134 0.0001102 0.00195
33 CATALYTIC COMPLEX 127 1038 0.0001097 0.00195
34 VACUOLAR PART 90 694 0.0001575 0.002706
35 MITOCHONDRIAL MATRIX 59 412 0.0001642 0.00274
36 CELL BODY 68 494 0.0001801 0.002922
37 DENDRITE 63 451 0.0002037 0.003216
38 LYTIC VACUOLE 71 526 0.000237 0.003642
39 SITE OF POLARIZED GROWTH 27 149 0.0002677 0.004009
40 ACTIN BASED CELL PROJECTION 31 181 0.0002809 0.004101
41 APICAL JUNCTION COMPLEX 24 128 0.0003401 0.004844
42 RECEPTOR COMPLEX 48 327 0.0003643 0.005065
43 TRANSFERASE COMPLEX 89 703 0.0003842 0.0051
44 GOLGI MEMBRANE 89 703 0.0003842 0.0051
45 INTRINSIC COMPONENT OF PLASMA MEMBRANE 185 1649 0.0003957 0.005136
46 CELL JUNCTION 135 1151 0.0004249 0.005394
47 BASOLATERAL PLASMA MEMBRANE 34 211 0.000473 0.005755
48 CONTRACTILE FIBER 34 211 0.000473 0.005755
49 VACUOLAR MEMBRANE 76 587 0.0005204 0.006202
50 EXCITATORY SYNAPSE 32 197 0.0005929 0.006925
51 CORTICAL CYTOSKELETON 17 81 0.0006408 0.007338
52 APICAL PLASMA MEMBRANE 43 292 0.0006703 0.007528
53 INTERSTITIAL MATRIX 6 14 0.0007755 0.008546
54 MITOCHONDRIAL ENVELOPE 86 691 0.0008149 0.008813

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 FoxO_signaling_pathway_hsa04068 33 132 3.237e-08 1.683e-06
2 AMPK_signaling_pathway_hsa04152 28 121 1.866e-06 4.851e-05
3 Cellular_senescence_hsa04218 32 160 9.902e-06 0.0001716
4 cGMP_PKG_signaling_pathway_hsa04022 30 163 9.41e-05 0.001223
5 Rap1_signaling_pathway_hsa04015 34 206 0.000301 0.00313
6 p53_signaling_pathway_hsa04115 15 68 0.0007589 0.006154
7 MAPK_signaling_pathway_hsa04010 43 295 0.0008284 0.006154
8 PI3K_Akt_signaling_pathway_hsa04151 48 352 0.001829 0.01189
9 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 23 139 0.002571 0.01486
10 Hippo_signaling_pathway_multiple_species_hsa04392 8 29 0.00297 0.01544
11 Phospholipase_D_signaling_pathway_hsa04072 23 146 0.004827 0.02282
12 HIF_1_signaling_pathway_hsa04066 17 100 0.006679 0.02702
13 Ferroptosis_hsa04216 9 40 0.007277 0.02702
14 mTOR_signaling_pathway_hsa04150 23 151 0.00729 0.02702
15 Tight_junction_hsa04530 25 170 0.008302 0.02702
16 Cell_adhesion_molecules_.CAMs._hsa04514 22 145 0.008941 0.02702
17 Hippo_signaling_pathway_hsa04390 23 154 0.009207 0.02702
18 Apelin_signaling_pathway_hsa04371 21 137 0.009353 0.02702
19 Adherens_junction_hsa04520 13 72 0.01008 0.0276
20 Peroxisome_hsa04146 14 83 0.01397 0.03632
21 TGF_beta_signaling_pathway_hsa04350 14 84 0.01544 0.03701
22 Sphingolipid_signaling_pathway_hsa04071 18 118 0.01606 0.03701
23 cAMP_signaling_pathway_hsa04024 27 198 0.01637 0.03701
24 Focal_adhesion_hsa04510 27 199 0.01739 0.03718
25 Autophagy_animal_hsa04140 19 128 0.01787 0.03718
26 Calcium_signaling_pathway_hsa04020 25 182 0.01869 0.03738
27 Gap_junction_hsa04540 14 88 0.02251 0.04336
28 Ras_signaling_pathway_hsa04014 30 232 0.02342 0.04349
29 Oocyte_meiosis_hsa04114 18 124 0.02547 0.04567
30 TNF_signaling_pathway_hsa04668 15 108 0.05413 0.09082
31 Phosphatidylinositol_signaling_system_hsa04070 14 99 0.05414 0.09082
32 Jak_STAT_signaling_pathway_hsa04630 20 162 0.08185 0.133
33 ABC_transporters_hsa02010 7 45 0.09974 0.1572
34 ErbB_signaling_pathway_hsa04012 11 85 0.1306 0.1998
35 Wnt_signaling_pathway_hsa04310 17 146 0.1499 0.2227
36 Lysosome_hsa04142 14 123 0.2008 0.29
37 Mitophagy_animal_hsa04137 8 65 0.2163 0.2989
38 Cytokine_cytokine_receptor_interaction_hsa04060 28 270 0.2184 0.2989
39 Notch_signaling_pathway_hsa04330 6 48 0.2502 0.3336
40 Cell_cycle_hsa04110 12 124 0.4205 0.5413
41 VEGF_signaling_pathway_hsa04370 6 59 0.4268 0.5413
42 Apoptosis_hsa04210 13 138 0.4528 0.5606
43 Regulation_of_actin_cytoskeleton_hsa04810 19 208 0.4819 0.5827
44 Autophagy_other_hsa04136 3 32 0.549 0.6488
45 Endocytosis_hsa04144 21 244 0.591 0.6829
46 NF_kappa_B_signaling_pathway_hsa04064 8 95 0.614 0.6941
47 ECM_receptor_interaction_hsa04512 6 82 0.7458 0.8195
48 Necroptosis_hsa04217 12 164 0.7967 0.8195
49 Hedgehog_signaling_pathway_hsa04340 3 47 0.7993 0.8195
50 Phagosome_hsa04145 11 152 0.8007 0.8195
51 Apoptosis_multiple_species_hsa04215 2 33 0.8038 0.8195
52 Neuroactive_ligand_receptor_interaction_hsa04080 18 278 0.9413 0.9413

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 RP11-116D2.1 hsa-miR-106b-5p;hsa-miR-132-3p;hsa-miR-182-5p;hsa-miR-212-3p;hsa-miR-218-5p;hsa-miR-25-3p;hsa-miR-27a-3p;hsa-miR-301a-3p;hsa-miR-421;hsa-miR-940 10 SLC1A2 Sponge network -1.423 2.0E-5 -2.052 1.0E-5 0.481

Quest ID: 435fdfd6b4ba0fed8bcb7fea287cf7f4