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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-15a-5p ABCB5 0 0 0 0 MirTarget -0.85 0 NA
2 hsa-miR-15a-5p ABHD13 0 0 0 0 MirTarget; miRNATAP -0.13 0 NA
3 hsa-miR-15a-5p ACOX1 0 0 0 0 miRNATAP -0.12 1.0E-5 NA
4 hsa-miR-15a-5p ACSL4 0 0 0 0 MirTarget; miRNATAP -0.35 0 NA
5 hsa-miR-15a-5p ACSS2 0 0 0 0 MirTarget -0.11 0.0013 NA
6 hsa-miR-15a-5p ACVR2A 0 0 0 0 MirTarget; miRNATAP -0.37 0 NA
7 hsa-miR-15a-5p ACVR2B 0 0 0 0 miRNATAP -0.18 0 NA
8 hsa-miR-15a-5p ADAMTS18 0 0 0 0 miRNATAP -0.6 0 NA
9 hsa-miR-15a-5p ADAMTS3 0 0 0 0 miRNATAP -0.4 0 NA
10 hsa-miR-15a-5p ADAMTS5 0 0 0 0 miRNATAP -0.79 0 NA
11 hsa-miR-15a-5p ADAMTSL3 0 0 0 0 MirTarget -0.46 0 NA
12 hsa-miR-15a-5p ADCY1 0 0 0 0 mirMAP -0.27 0.00416 NA
13 hsa-miR-15a-5p ADCY5 0 0 0 0 MirTarget; miRNATAP -0.65 0 NA
14 hsa-miR-15a-5p ADRB2 0 0 0 0 MirTarget -0.5 0 NA
15 hsa-miR-15a-5p AEBP2 0 0 0 0 MirTarget -0.14 0 NA
16 hsa-miR-15a-5p AFF4 0 0 0 0 MirTarget; miRNATAP -0.32 0 NA
17 hsa-miR-15a-5p AGPAT4 0 0 0 0 mirMAP -0.11 0.01325 NA
18 hsa-miR-15a-5p AHCYL2 0 0 0 0 miRNATAP -0.19 0 NA
19 hsa-miR-15a-5p AKAP11 0 0 0 0 MirTarget; miRNATAP -0.26 0 NA
20 hsa-miR-15a-5p AKT3 0 0 0 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.51 0 NA
21 hsa-miR-15a-5p ALX4 0 0 0 0 mirMAP -0.84 0 NA
22 hsa-miR-15a-5p AMMECR1L 0 0 0 0 MirTarget -0.15 0 NA
23 hsa-miR-15a-5p AMOTL1 0 0 0 0 MirTarget; miRNATAP -0.53 0 NA
24 hsa-miR-15a-5p ANK2 0 0 0 0 MirTarget; miRNATAP -0.47 0 NA
25 hsa-miR-15a-5p ANKIB1 0 0 0 0 miRNATAP -0.19 0 NA
26 hsa-miR-15a-5p ANKRD29 0 0 0 0 MirTarget -0.53 0 NA
27 hsa-miR-15a-5p ANKRD46 0 0 0 0 MirTarget -0.13 5.0E-5 NA
28 hsa-miR-15a-5p ANKS1A 0 0 0 0 MirTarget -0.12 0 NA
29 hsa-miR-15a-5p ANO3 0 0 0 0 MirTarget; miRNATAP -0.65 0 NA
30 hsa-miR-15a-5p APLNR 0 0 0 0 MirTarget -0.12 0.00686 NA
31 hsa-miR-15a-5p APP 0 0 0 0 miRNAWalker2 validate; miRNATAP -0.18 0 NA
32 hsa-miR-15a-5p AR 0 0 0 0 mirMAP; miRNATAP -0.95 0 NA
33 hsa-miR-15a-5p ARHGAP12 0 0 0 0 miRNATAP -0.3 0 NA
34 hsa-miR-15a-5p ARHGAP19 0 0 0 0 MirTarget; mirMAP -0.22 0 NA
35 hsa-miR-15a-5p ARHGAP20 0 0 0 0 MirTarget; miRNATAP -0.87 0 NA
36 hsa-miR-15a-5p ARHGAP32 0 0 0 0 MirTarget -0.29 0 NA
37 hsa-miR-15a-5p ARHGAP5 0 0 0 0 MirTarget; miRNATAP -0.38 0 NA
38 hsa-miR-15a-5p ARHGEF12 0 0 0 0 MirTarget -0.38 0 NA
39 hsa-miR-15a-5p ARIH1 0 0 0 0 MirTarget -0.23 0 NA
40 hsa-miR-15a-5p ARMC8 0 0 0 0 MirTarget; miRNATAP -0.1 0 NA
41 hsa-miR-15a-5p ASB1 0 0 0 0 MirTarget; miRNATAP -0.1 5.0E-5 NA
42 hsa-miR-15a-5p ASH1L 0 0 0 0 MirTarget; miRNATAP -0.29 0 NA
43 hsa-miR-15a-5p ASNSD1 0 0 0 0 miRNAWalker2 validate -0.11 0 NA
44 hsa-miR-15a-5p ASPH 0 0 0 0 miRNATAP -0.29 0 NA
45 hsa-miR-15a-5p ASTN1 0 0 0 0 MirTarget -0.73 0 NA
46 hsa-miR-15a-5p ASXL2 0 0 0 0 miRNAWalker2 validate -0.58 0 NA
47 hsa-miR-15a-5p ATF2 0 0 0 0 miRNAWalker2 validate -0.36 0 NA
48 hsa-miR-15a-5p ATF6 0 0 0 0 MirTarget -0.16 0 NA
49 hsa-miR-15a-5p ATP13A3 0 0 0 0 MirTarget; miRNATAP -0.17 0 NA
50 hsa-miR-15a-5p ATP7A 0 0 0 0 MirTarget -0.39 0 NA
51 hsa-miR-15a-5p ATP8A1 0 0 0 0 MirTarget -0.26 0 NA
52 hsa-miR-15a-5p ATXN1L 0 0 0 0 miRNATAP -0.34 0 NA
53 hsa-miR-15a-5p ATXN7L1 0 0 0 0 miRNATAP -0.14 0 NA
54 hsa-miR-15a-5p ATXN7L3B 0 0 0 0 MirTarget -0.2 0 NA
55 hsa-miR-15a-5p AVL9 0 0 0 0 MirTarget; miRNATAP -0.27 0 NA
56 hsa-miR-15a-5p AXIN2 0 0 0 0 MirTarget; miRNATAP -0.31 0 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy
57 hsa-miR-15a-5p BACE1 0 0 0 0 miRNAWalker2 validate; miRNATAP -0.27 0 NA
58 hsa-miR-15a-5p BACH2 0 0 0 0 MirTarget; miRNATAP -0.57 0 NA
59 hsa-miR-15a-5p BAG4 0 0 0 0 MirTarget -0.3 0 NA
60 hsa-miR-15a-5p BAG5 0 0 0 0 miRNATAP -0.16 0 NA
61 hsa-miR-15a-5p BAZ2A 0 0 0 0 miRNATAP -0.14 0 NA
62 hsa-miR-15a-5p BCL2 0 0 0 0 miRNAWalker2 validate; miRTarBase -0.39 0 25594541; 22335947; 26915294; 18931683; 25623762 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells
63 hsa-miR-15a-5p BCL2L13 0 0 0 0 MirTarget -0.1 0 NA
64 hsa-miR-15a-5p BCL2L2 0 0 0 0 MirTarget; miRNATAP -0.12 0 25874488 MicroRNA 15a induces cell apoptosis and inhibits metastasis by targeting BCL2L2 in non small cell lung cancer; Furthermore we identified that BCL2L2 was a target of miR-15a and negatively regulated by miR-15a at the translational level; miR-15a acts as a tumor suppressor in NSCLC by directly targeting BCL2L2 and may serve as a potential diagnostic biomarker and therapeutic target for NSCLC
65 hsa-miR-15a-5p BDNF 0 0 0 0 MirTarget; miRNATAP -0.27 0.0009 26581909 MicroRNA 15a 5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF; BDNF was then overexpressed in HepG2 and SNU-182 cells to evaluate its selective effect on miR-15a-5p in HCC modulation; MiR-15a-5p selectively and negatively regulated BDNF at both gene and protein levels in HCC cells; Forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-15a-5p on HCC proliferation and cell division in vitro; Our study demonstrated that miR-15a-5p is a tumor suppressor in HCC and its regulation is through BDNF in HCC
66 hsa-miR-15a-5p BHLHE41 0 0 0 0 miRNATAP -0.5 0 NA
67 hsa-miR-15a-5p BMI1 0 0 0 0 miRNAWalker2 validate; miRTarBase -0.11 0.00226 27596816 Our results suggest that overexpression of miR-15a and miR-16 mediates down-regulation of BMI1 and leads to mitochondrial mediated apoptosis
68 hsa-miR-15a-5p BMX 0 0 0 0 MirTarget; miRNATAP -0.66 0 NA
69 hsa-miR-15a-5p BPTF 0 0 0 0 miRNATAP -0.3 0 NA
70 hsa-miR-15a-5p BRPF3 0 0 0 0 miRNATAP -0.17 0 NA
71 hsa-miR-15a-5p BRWD1 0 0 0 0 miRNAWalker2 validate -0.18 0 NA
72 hsa-miR-15a-5p BRWD3 0 0 0 0 MirTarget -0.32 0 NA
73 hsa-miR-15a-5p BTAF1 0 0 0 0 MirTarget -0.33 0 NA
74 hsa-miR-15a-5p BTBD19 0 0 0 0 mirMAP -0.28 0 NA
75 hsa-miR-15a-5p BTG2 0 0 0 0 MirTarget; miRNATAP -0.18 0.00165 NA
76 hsa-miR-15a-5p BTRC 0 0 0 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.19 0 NA
77 hsa-miR-15a-5p BVES 0 0 0 0 MirTarget -0.42 0 NA
78 hsa-miR-15a-5p C16orf52 0 0 0 0 miRNATAP -0.15 0 NA
79 hsa-miR-15a-5p C1QL3 0 0 0 0 miRNATAP -0.36 1.0E-5 NA
80 hsa-miR-15a-5p C1orf21 0 0 0 0 mirMAP; miRNATAP -0.2 0.00024 NA
81 hsa-miR-15a-5p C2orf72 0 0 0 0 miRNATAP -0.52 0 NA
82 hsa-miR-15a-5p C3orf58 0 0 0 0 miRNATAP -0.19 2.0E-5 NA
83 hsa-miR-15a-5p CAB39 0 0 0 0 miRNATAP -0.15 0 NA
84 hsa-miR-15a-5p CACNB4 0 0 0 0 miRNATAP -0.52 0 NA
85 hsa-miR-15a-5p CADM1 0 0 0 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.2 4.0E-5 NA
86 hsa-miR-15a-5p CALD1 0 0 0 0 miRNAWalker2 validate -0.39 0 NA
87 hsa-miR-15a-5p CALN1 0 0 0 0 mirMAP -0.67 0 NA
88 hsa-miR-15a-5p CAMSAP1 0 0 0 0 MirTarget; miRNATAP -0.11 0 NA
89 hsa-miR-15a-5p CAPN6 0 0 0 0 miRNATAP -0.43 0.0014 NA
90 hsa-miR-15a-5p CAPRIN1 0 0 0 0 MirTarget -0.11 1.0E-5 NA
91 hsa-miR-15a-5p CAPZA2 0 0 0 0 MirTarget -0.11 0 NA
92 hsa-miR-15a-5p CASK 0 0 0 0 MirTarget; miRNATAP -0.14 1.0E-5 NA
93 hsa-miR-15a-5p CASZ1 0 0 0 0 MirTarget -0.11 0.00585 NA
94 hsa-miR-15a-5p CBX5 0 0 0 0 miRNATAP -0.15 0 NA
95 hsa-miR-15a-5p CCDC144A 0 0 0 0 mirMAP -0.57 0 NA
96 hsa-miR-15a-5p CCDC6 0 0 0 0 MirTarget; miRNATAP -0.18 0 NA
97 hsa-miR-15a-5p CCND2 0 0 0 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.38 0 NA
98 hsa-miR-15a-5p CCNJ 0 0 0 0 miRNATAP -0.14 1.0E-5 NA
99 hsa-miR-15a-5p CCNJL 0 0 0 0 miRNATAP -0.26 2.0E-5 NA
100 hsa-miR-15a-5p CCNT1 0 0 0 0 miRNATAP -0.76 0 NA
101 hsa-miR-15a-5p CCNT2 0 0 0 0 MirTarget; miRNATAP -0.22 0 NA
102 hsa-miR-15a-5p CCNYL1 0 0 0 0 miRNAWalker2 validate -0.13 2.0E-5 NA
103 hsa-miR-15a-5p CCT6B 0 0 0 0 miRNAWalker2 validate -0.15 0.00017 NA
104 hsa-miR-15a-5p CD164 0 0 0 0 MirTarget; miRNATAP -0.11 0.00014 NA
105 hsa-miR-15a-5p CD274 0 0 0 0 MirTarget -0.29 0 NA
106 hsa-miR-15a-5p CD2AP 0 0 0 0 miRNATAP -0.12 4.0E-5 NA
107 hsa-miR-15a-5p CD47 0 0 0 0 MirTarget -0.16 0 NA
108 hsa-miR-15a-5p CDC14B 0 0 0 0 miRNAWalker2 validate; MirTarget -0.48 0 NA
109 hsa-miR-15a-5p CDC27 0 0 0 0 miRNATAP -0.13 0 NA
110 hsa-miR-15a-5p CDC42SE2 0 0 0 0 MirTarget -0.15 0 NA
111 hsa-miR-15a-5p CDK17 0 0 0 0 MirTarget; miRNATAP -0.24 0 NA
112 hsa-miR-15a-5p CDK6 0 0 0 0 miRNATAP -0.31 0 NA
113 hsa-miR-15a-5p CDS2 0 0 0 0 mirMAP; miRNATAP -0.11 0 NA
114 hsa-miR-15a-5p CEP350 0 0 0 0 miRNATAP -0.18 0 NA
115 hsa-miR-15a-5p CHD2 0 0 0 0 MirTarget -0.17 0 NA
116 hsa-miR-15a-5p CHD9 0 0 0 0 miRNATAP -0.44 0 NA
117 hsa-miR-15a-5p CHPT1 0 0 0 0 MirTarget; miRNATAP -0.18 8.0E-5 NA
118 hsa-miR-10a-5p CHRNA5 0 0 0 0 miRNAWalker2 validate -0.35 0 NA
119 hsa-miR-15a-5p CHUK 0 0 0 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.14 0 NA
120 hsa-miR-15a-5p CLCN3 0 0 0 0 miRTarBase -0.4 0 NA
121 hsa-miR-15a-5p CLDN12 0 0 0 0 MirTarget; miRNATAP -0.17 0 NA
122 hsa-miR-15a-5p CLOCK 0 0 0 0 MirTarget -0.45 0 NA
123 hsa-miR-15a-5p CNKSR2 0 0 0 0 miRNATAP -0.71 0 NA
124 hsa-miR-15a-5p CNN1 0 0 0 0 miRNATAP -0.66 0 NA
125 hsa-miR-15a-5p CNN3 0 0 0 0 miRNAWalker2 validate -0.24 0 NA
126 hsa-miR-15a-5p COBLL1 0 0 0 0 MirTarget; miRNATAP -0.4 0 NA
127 hsa-miR-15a-5p COL12A1 0 0 0 0 MirTarget; miRNATAP -0.32 0 NA
128 hsa-miR-15a-5p COL4A3BP 0 0 0 0 MirTarget; miRNATAP -0.3 0 NA
129 hsa-miR-15a-5p COPS2 0 0 0 0 MirTarget -0.15 0 NA
130 hsa-miR-15a-5p CPD 0 0 0 0 MirTarget; miRNATAP -0.32 0 NA
131 hsa-miR-15a-5p CPEB2 0 0 0 0 miRNATAP -0.29 0 NA
132 hsa-miR-15a-5p CPEB3 0 0 0 0 MirTarget; miRNATAP -0.3 0 NA
133 hsa-miR-15a-5p CREB5 0 0 0 0 miRNATAP -0.46 0 NA
134 hsa-miR-15a-5p CREBL2 0 0 0 0 miRNAWalker2 validate -0.23 0 NA
135 hsa-miR-15a-5p CRIM1 0 0 0 0 MirTarget; miRNATAP -0.55 0 NA
136 hsa-miR-15a-5p CRTC3 0 0 0 0 miRNATAP -0.15 0 NA
137 hsa-miR-15a-5p CSDE1 0 0 0 0 MirTarget; miRNATAP -0.17 0 NA
138 hsa-miR-15a-5p CSF1 0 0 0 0 miRNATAP -0.1 0.02245 NA
139 hsa-miR-15a-5p CSRNP1 0 0 0 0 MirTarget -0.25 0 NA
140 hsa-miR-15a-5p CTDSPL 0 0 0 0 miRNATAP -0.16 0 NA
141 hsa-miR-15a-5p CX3CL1 0 0 0 0 miRNATAP -0.32 1.0E-5 NA
142 hsa-miR-15a-5p CYP26B1 0 0 0 0 MirTarget; miRNATAP -0.24 0.00048 NA
143 hsa-miR-15a-5p CYS1 0 0 0 0 mirMAP -0.43 0 NA
144 hsa-miR-15a-5p DCAF5 0 0 0 0 MirTarget; miRNATAP -0.1 0 NA
145 hsa-miR-15a-5p DCLK1 0 0 0 0 miRNATAP -0.25 0.00208 NA
146 hsa-miR-15a-5p DCP1A 0 0 0 0 MirTarget -0.22 0 NA
147 hsa-miR-15a-5p DCUN1D1 0 0 0 0 MirTarget -0.2 0 NA
148 hsa-miR-15a-5p DCX 0 0 0 0 mirMAP -0.42 0.00244 NA
149 hsa-miR-15a-5p DDX3X 0 0 0 0 miRNATAP -0.24 0 NA
150 hsa-miR-15a-5p DENND1B 0 0 0 0 miRNATAP -0.28 2.0E-5 NA
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEIN PHOSPHORYLATION 80 944 1.21e-14 5.632e-11
2 CARDIOVASCULAR SYSTEM DEVELOPMENT 67 788 1.804e-12 2.798e-09
3 CIRCULATORY SYSTEM DEVELOPMENT 67 788 1.804e-12 2.798e-09
4 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 121 1977 2.197e-11 2.555e-08
5 PHOSPHORYLATION 85 1228 9.683e-11 9.011e-08
6 NEUROGENESIS 90 1402 1.228e-09 8.434e-07
7 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 107 1784 1.269e-09 8.434e-07
8 HEART DEVELOPMENT 42 466 5.5e-09 3.199e-06
9 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 53 689 1.393e-08 6.481e-06
10 CELL DEVELOPMENT 88 1426 1.264e-08 6.481e-06
11 ORGAN MORPHOGENESIS 60 841 2.375e-08 8.845e-06
12 REGULATION OF CELL DIFFERENTIATION 90 1492 2.475e-08 8.845e-06
13 RESPONSE TO GROWTH FACTOR 41 475 2.851e-08 8.845e-06
14 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 13 56 2.786e-08 8.845e-06
15 TISSUE DEVELOPMENT 91 1518 2.742e-08 8.845e-06
16 INTRACELLULAR SIGNAL TRANSDUCTION 93 1572 3.537e-08 1.028e-05
17 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 67 1008 5.408e-08 1.48e-05
18 VASCULATURE DEVELOPMENT 40 469 5.843e-08 1.51e-05
19 CELLULAR COMPONENT MORPHOGENESIS 60 900 2.539e-07 6.217e-05
20 POSITIVE REGULATION OF GENE EXPRESSION 96 1733 4.521e-07 0.0001047
21 NEURON DIFFERENTIATION 58 874 4.724e-07 0.0001047
22 HEAD DEVELOPMENT 50 709 5.204e-07 0.0001101
23 CENTRAL NERVOUS SYSTEM DEVELOPMENT 57 872 9.638e-07 0.000195
24 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 92 1672 1.087e-06 0.0002107
25 REGULATION OF DEVELOPMENTAL GROWTH 27 289 1.513e-06 0.0002593
26 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 97 1805 1.512e-06 0.0002593
27 PROTEIN DEPHOSPHORYLATION 21 190 1.56e-06 0.0002593
28 CYTOSKELETON DEPENDENT INTRACELLULAR TRANSPORT 16 116 1.506e-06 0.0002593
29 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 60 957 1.92e-06 0.0003081
30 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 56 873 2.152e-06 0.0003338
31 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 90 1656 2.413e-06 0.0003622
32 RESPONSE TO ENDOGENOUS STIMULUS 81 1450 2.92e-06 0.0004246
33 FOREBRAIN DEVELOPMENT 30 357 3.603e-06 0.0004831
34 MUSCLE STRUCTURE DEVELOPMENT 34 432 3.516e-06 0.0004831
35 POSITIVE REGULATION OF CELL DIFFERENTIATION 53 823 3.634e-06 0.0004831
36 DEPHOSPHORYLATION 26 286 3.899e-06 0.000504
37 SKELETAL SYSTEM DEVELOPMENT 35 455 4.214e-06 0.0005299
38 EMBRYO DEVELOPMENT 56 894 4.405e-06 0.0005393
39 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 67 1142 4.613e-06 0.0005504
40 POSITIVE REGULATION OF LOCOMOTION 33 420 5.064e-06 0.000589
41 NEURON PROJECTION DEVELOPMENT 39 545 6.763e-06 0.0007675
42 REGULATION OF MUSCLE TISSUE DEVELOPMENT 14 103 8.032e-06 0.0008691
43 REGULATION OF MUSCLE ORGAN DEVELOPMENT 14 103 8.032e-06 0.0008691
44 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 22 229 8.945e-06 0.0009003
45 HEART MORPHOGENESIS 21 212 8.891e-06 0.0009003
46 REGULATION OF PROTEIN MODIFICATION PROCESS 90 1710 8.741e-06 0.0009003
47 REGULATION OF CELL MORPHOGENESIS 39 552 9.094e-06 0.0009003
48 PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 16 134 1.012e-05 0.0009233
49 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 37 513 9.765e-06 0.0009233
50 REGULATION OF PHOSPHORUS METABOLIC PROCESS 86 1618 9.799e-06 0.0009233
51 BIOLOGICAL ADHESION 61 1032 1.005e-05 0.0009233
52 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 36 498 1.224e-05 0.001096
53 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 71 1275 1.401e-05 0.00123
54 POSITIVE REGULATION OF SKELETAL MUSCLE TISSUE DEVELOPMENT 7 26 1.665e-05 0.001394
55 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 59 1004 1.678e-05 0.001394
56 INOSITOL LIPID MEDIATED SIGNALING 15 124 1.626e-05 0.001394
57 MUSCLE ORGAN DEVELOPMENT 24 277 2.03e-05 0.001657
58 DEVELOPMENTAL GROWTH 27 333 2.082e-05 0.001671
59 EPITHELIUM DEVELOPMENT 56 945 2.191e-05 0.001728
60 COLUMNAR CUBOIDAL EPITHELIAL CELL DEVELOPMENT 9 48 2.5e-05 0.001939
61 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 59 1021 2.731e-05 0.002083
62 NEURON DEVELOPMENT 44 687 2.818e-05 0.002115
63 PATTERN SPECIFICATION PROCESS 31 418 3.006e-05 0.00222
64 PROTEIN UBIQUITINATION 41 629 3.553e-05 0.002583
65 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 46 740 3.866e-05 0.002768
66 REGIONALIZATION 25 311 4.806e-05 0.003388
67 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 37 554 5.137e-05 0.003519
68 REGULATION OF CELLULAR COMPONENT MOVEMENT 47 771 5.143e-05 0.003519
69 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 5 14 6.288e-05 0.00424
70 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 26 337 6.79e-05 0.004476
71 PROTEIN POLYUBIQUITINATION 21 243 6.829e-05 0.004476
72 NEURON MIGRATION 13 110 7.526e-05 0.004864
73 ANTERIOR POSTERIOR PATTERN SPECIFICATION 18 194 9.015e-05 0.005692
74 NEGATIVE REGULATION OF OSSIFICATION 10 69 9.052e-05 0.005692
75 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 15 144 9.43e-05 0.00585
76 BLOOD VESSEL MORPHOGENESIS 27 364 9.624e-05 0.005892
77 REGULATION OF OSSIFICATION 17 178 9.834e-05 0.005943
78 EMBRYONIC PATTERN SPECIFICATION 9 58 0.000118 0.007042
79 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 57 1036 0.0001405 0.008071
80 REGULATION OF EPITHELIAL CELL MIGRATION 16 166 0.0001403 0.008071
81 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 57 1036 0.0001405 0.008071
82 TISSUE REMODELING 11 87 0.0001446 0.008205
83 POSITIVE REGULATION OF GROWTH 20 238 0.0001478 0.008284
84 GLAND DEVELOPMENT 28 395 0.0001553 0.008603
85 REGULATION OF DENDRITE MORPHOGENESIS 10 74 0.0001648 0.008793
86 PEPTIDYL TYROSINE MODIFICATION 17 186 0.0001682 0.008793
87 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 12 103 0.0001618 0.008793
88 CELL PROJECTION ORGANIZATION 51 902 0.0001649 0.008793
89 CELL GROWTH 14 135 0.0001676 0.008793
90 CELL CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 18 204 0.0001706 0.00882
91 MEMBRANE DEPOLARIZATION 9 61 0.0001759 0.008975
92 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 12 104 0.0001775 0.008975
93 REGULATION OF CELL DEVELOPMENT 48 836 0.0001799 0.009002
94 POSITIVE REGULATION OF CELL COMMUNICATION 77 1532 0.0001832 0.00907
95 PALLIUM DEVELOPMENT 15 153 0.0001862 0.00912
96 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 8 49 0.0001955 0.009475
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEIN KINASE ACTIVITY 63 640 1.255e-14 1.166e-11
2 KINASE ACTIVITY 69 842 4.533e-12 2.106e-09
3 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 72 992 3.956e-10 1.225e-07
4 PROTEIN SERINE THREONINE KINASE ACTIVITY 42 445 1.395e-09 3.241e-07
5 ADENYL NUCLEOTIDE BINDING 89 1514 9.684e-08 1.799e-05
6 ENZYME BINDING 98 1737 1.431e-07 2.215e-05
7 UBIQUITIN LIKE PROTEIN TRANSFERASE ACTIVITY 35 420 6.833e-07 9.069e-05
8 RIBONUCLEOTIDE BINDING 100 1860 9.928e-07 0.0001153
9 UBIQUITIN LIKE PROTEIN LIGASE ACTIVITY 21 199 3.289e-06 0.0003395
10 SMAD BINDING 12 72 4.154e-06 0.000386
11 PHOSPHATASE ACTIVITY 25 275 5.961e-06 0.0005035
12 PROTEIN SERINE THREONINE PHOSPHATASE ACTIVITY 11 64 7.671e-06 0.0005789
13 PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 19 178 8.1e-06 0.0005789
14 UBIQUITIN LIKE PROTEIN CONJUGATING ENZYME BINDING 8 34 1.222e-05 0.0008109
15 MACROMOLECULAR COMPLEX BINDING 76 1399 1.619e-05 0.001003
16 KINASE BINDING 40 606 3.343e-05 0.001941
17 PHOSPHATIDYLINOSITOL PHOSPHATE PHOSPHATASE ACTIVITY 7 29 3.621e-05 0.001979
18 ZINC ION BINDING 64 1155 4.409e-05 0.002275
19 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 11 81 7.496e-05 0.003665
20 PROTEIN TYROSINE KINASE ACTIVITY 17 176 8.551e-05 0.003972
21 LIGASE ACTIVITY 29 406 0.0001044 0.004621
22 PHOSPHORIC ESTER HYDROLASE ACTIVITY 27 368 0.0001154 0.004872
23 PDZ DOMAIN BINDING 11 90 0.0001963 0.00793
24 MICROTUBULE MOTOR ACTIVITY 10 77 0.0002301 0.008906
25 ATP DEPENDENT MICROTUBULE MOTOR ACTIVITY 5 18 0.0002409 0.008951
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PART 80 1265 2.206e-08 1.288e-05
2 NEURON PROJECTION 64 942 4.936e-08 1.441e-05
3 CELL PROJECTION 101 1786 7.945e-08 1.547e-05
4 SOMATODENDRITIC COMPARTMENT 43 650 1.613e-05 0.002354
5 TRANSFERASE COMPLEX 45 703 2.317e-05 0.002706
6 CELL PROJECTION PART 55 946 4.371e-05 0.004254
7 VOLTAGE GATED SODIUM CHANNEL COMPLEX 5 14 6.288e-05 0.00459
8 SYNAPSE 46 754 6.063e-05 0.00459
9 KINESIN COMPLEX 9 55 7.703e-05 0.004998
10 RECEPTOR COMPLEX 25 327 0.0001076 0.006283
11 DENDRITE 31 451 0.000123 0.006532
12 AXON 29 418 0.0001723 0.007667
13 PROTEIN KINASE COMPLEX 11 90 0.0001963 0.007667
14 SODIUM CHANNEL COMPLEX 5 17 0.0001789 0.007667
15 UBIQUITIN LIGASE COMPLEX 21 262 0.0001969 0.007667

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 PI3K_Akt_signaling_pathway_hsa04151 32 352 3.048e-07 1.585e-05
2 MAPK_signaling_pathway_hsa04010 28 295 7.07e-07 1.838e-05
3 Focal_adhesion_hsa04510 19 199 3.924e-05 0.0005881
4 mTOR_signaling_pathway_hsa04150 16 151 4.524e-05 0.0005881
5 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 14 139 0.0002281 0.002208
6 Oocyte_meiosis_hsa04114 13 124 0.0002547 0.002208
7 Autophagy_animal_hsa04140 13 128 0.0003483 0.002587
8 FoxO_signaling_pathway_hsa04068 13 132 0.0004696 0.003052
9 Rap1_signaling_pathway_hsa04015 17 206 0.0005574 0.003221
10 Ras_signaling_pathway_hsa04014 18 232 0.0008043 0.004182
11 cGMP_PKG_signaling_pathway_hsa04022 14 163 0.001135 0.005364
12 Regulation_of_actin_cytoskeleton_hsa04810 16 208 0.001678 0.00727
13 Apelin_signaling_pathway_hsa04371 12 137 0.002118 0.008472
14 AMPK_signaling_pathway_hsa04152 11 121 0.002388 0.008551
15 Hippo_signaling_pathway_multiple_species_hsa04392 5 29 0.002467 0.008551
16 Cellular_senescence_hsa04218 13 160 0.002749 0.008933
17 TNF_signaling_pathway_hsa04668 10 108 0.003242 0.009918
18 Mitophagy_animal_hsa04137 7 65 0.005749 0.01576
19 Phosphatidylinositol_signaling_system_hsa04070 9 99 0.00576 0.01576
20 cAMP_signaling_pathway_hsa04024 13 198 0.01556 0.04045
21 Endocytosis_hsa04144 15 244 0.01705 0.04223
22 ECM_receptor_interaction_hsa04512 7 82 0.01942 0.04418
23 Hedgehog_signaling_pathway_hsa04340 5 47 0.01954 0.04418
24 Phospholipase_D_signaling_pathway_hsa04072 10 146 0.0244 0.05074
25 Wnt_signaling_pathway_hsa04310 10 146 0.0244 0.05074
26 p53_signaling_pathway_hsa04115 6 68 0.02551 0.05103
27 Gap_junction_hsa04540 7 88 0.02741 0.05279
28 Calcium_signaling_pathway_hsa04020 11 182 0.04159 0.07723
29 Tight_junction_hsa04530 10 170 0.05854 0.105
30 Hippo_signaling_pathway_hsa04390 9 154 0.07259 0.1258
31 Notch_signaling_pathway_hsa04330 4 48 0.07507 0.1259
32 Adherens_junction_hsa04520 5 72 0.09178 0.1491
33 Sphingolipid_signaling_pathway_hsa04071 7 118 0.09929 0.1565
34 HIF_1_signaling_pathway_hsa04066 6 100 0.1168 0.1786
35 VEGF_signaling_pathway_hsa04370 4 59 0.1331 0.1978
36 TGF_beta_signaling_pathway_hsa04350 5 84 0.1483 0.2142
37 Jak_STAT_signaling_pathway_hsa04630 8 162 0.1736 0.2429
38 Apoptosis_hsa04210 7 138 0.1775 0.2429
39 Cell_cycle_hsa04110 6 124 0.2325 0.31
40 Peroxisome_hsa04146 4 83 0.299 0.3887
41 ErbB_signaling_pathway_hsa04012 4 85 0.3141 0.3984
42 Cell_adhesion_molecules_.CAMs._hsa04514 6 145 0.3533 0.4374
43 Ferroptosis_hsa04216 2 40 0.3865 0.4609
44 NF_kappa_B_signaling_pathway_hsa04064 4 95 0.39 0.4609
45 Neuroactive_ligand_receptor_interaction_hsa04080 8 278 0.7113 0.8041
46 Phagosome_hsa04145 4 152 0.7494 0.8291
47 Cytokine_cytokine_receptor_interaction_hsa04060 7 270 0.7989 0.8478
48 Lysosome_hsa04142 2 123 0.9194 0.9561
49 Necroptosis_hsa04217 2 164 0.9747 0.9938

Quest ID: 4439311c76040a1d487a1929ea08adca