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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-142-3p CDC6 -1.42 0 3.43 0 miRNAWalker2 validate -0.21 0.0024 NA
2 hsa-miR-193b-3p CDC6 -0.17 0.27202 3.43 0 miRNAWalker2 validate -0.18 0.04519 NA
3 hsa-miR-199a-5p CDC6 -1.99 0 3.43 0 miRanda -0.27 0 NA
4 hsa-miR-26a-5p CDC6 -0.96 0 3.43 0 miRNAWalker2 validate -0.79 0 25100863; 27158389 Here it is demonstrated that miR26a and miR26b inhibit replication licensing and the proliferation migration and invasion of lung cancer cells by targeting CDC6; The current study suggests that miR26a miR26b and CDC6 and factors regulating their expression represent potential cancer diagnostic and prognostic markers as well as anticancer targets;miR 26a inhibits the proliferation of ovarian cancer cells via regulating CDC6 expression; Bioinformatics analysis revealed Cdc6 was a target gene of miR-26a; dual-luciferase assay and validation assay showed miR-26a could act on the 3'UTR of Cdc6 to regulate Cdc6 expression; These findings suggest that miR-26a may act on the 3'UTR of Cdc6 to regulate Cdc6 expression which then inhibit the proliferation of ovarian cancer cells and induce their apoptosis
5 hsa-miR-3607-3p CDC6 -2.16 0 3.43 0 mirMAP -0.42 0 NA
6 hsa-miR-101-3p CDC7 -1.48 0 2.02 0 miRNAWalker2 validate -0.62 0 NA
7 hsa-miR-126-5p CDC7 -0.43 7.0E-5 2.02 0 mirMAP -0.39 1.0E-5 NA
8 hsa-miR-192-5p CDC7 -0.5 0.00345 2.02 0 miRNAWalker2 validate -0.2 0.00036 NA
9 hsa-miR-199a-5p CDC7 -1.99 0 2.02 0 MirTarget; miRanda -0.11 0.00038 NA
10 hsa-miR-215-5p CDC7 -0.98 3.0E-5 2.02 0 miRNAWalker2 validate -0.11 0.00749 NA
11 hsa-miR-3065-3p CDC7 -1.04 5.0E-5 2.02 0 MirTarget -0.13 0.00068 NA
12 hsa-miR-335-5p CDC7 -1.61 0 2.02 0 MirTarget -0.18 0.00032 NA
13 hsa-miR-3607-3p CDC7 -2.16 0 2.02 0 miRNATAP -0.28 0 NA
14 hsa-miR-455-5p CDC7 -0.27 0.05813 2.02 0 miRanda -0.14 0.03623 NA
15 hsa-miR-195-3p DBF4 -1.09 0 0.92 0 mirMAP -0.12 8.0E-5 NA
16 hsa-miR-30a-5p DBF4 -0.63 0.00011 0.92 0 MirTarget -0.23 0 NA
17 hsa-miR-30b-5p DBF4 -0.54 2.0E-5 0.92 0 MirTarget -0.12 0.0115 NA
18 hsa-miR-30e-5p DBF4 -0.63 0 0.92 0 MirTarget -0.17 0.00391 NA
19 hsa-miR-3607-3p DBF4 -2.16 0 0.92 0 MirTarget; miRNATAP -0.16 0 NA
20 hsa-miR-542-3p DBF4 -1.31 0 0.92 0 miRanda -0.13 0.00125 NA
21 hsa-miR-126-5p MCM10 -0.43 7.0E-5 3.45 0 mirMAP -0.82 0 NA
22 hsa-miR-192-5p MCM10 -0.5 0.00345 3.45 0 miRNAWalker2 validate -0.21 0.01514 NA
23 hsa-miR-199a-5p MCM10 -1.99 0 3.45 0 miRanda -0.26 0 NA
24 hsa-miR-215-5p MCM10 -0.98 3.0E-5 3.45 0 miRNAWalker2 validate -0.16 0.0102 NA
25 hsa-miR-326 MCM10 -1.88 0 3.45 0 miRanda -0.25 0.0003 NA
26 hsa-miR-139-5p MCM2 -2.11 0 2.39 0 miRanda -0.6 0 NA
27 hsa-miR-192-5p MCM3 -0.5 0.00345 1.38 0 miRNAWalker2 validate -0.12 0.00283 NA
28 hsa-miR-193b-3p MCM3 -0.17 0.27202 1.38 0 miRNAWalker2 validate -0.11 0.015 NA
29 hsa-miR-26b-5p MCM3 -1.11 0 1.38 0 miRNAWalker2 validate -0.34 0 NA
30 hsa-miR-450b-5p MCM3 -1.34 0 1.38 0 miRNATAP -0.22 0 NA
31 hsa-let-7b-5p MCM4 -0.96 0 1.33 0 miRNAWalker2 validate -0.13 0.02556 NA
32 hsa-miR-193b-3p MCM4 -0.17 0.27202 1.33 0 miRNAWalker2 validate -0.14 0.01696 NA
33 hsa-miR-486-5p MCM4 -1.78 0 1.33 0 miRanda -0.14 0.00013 NA
34 hsa-miR-542-3p MCM5 -1.31 0 1.34 0 miRanda -0.28 0 NA
35 hsa-miR-192-5p MCM6 -0.5 0.00345 1.69 0 miRNAWalker2 validate -0.13 0.00416 NA
36 hsa-miR-30c-1-3p MCM6 -1.39 0 1.69 0 MirTarget -0.13 0.00482 NA
37 hsa-miR-30c-2-3p MCM6 -1.4 0 1.69 0 MirTarget -0.27 0 NA
38 hsa-let-7b-5p MCM7 -0.96 0 1.29 0 miRNAWalker2 validate -0.25 0 NA
39 hsa-miR-99a-5p MCM8 -1.51 0 1.27 0 miRNAWalker2 validate -0.22 0 NA
40 hsa-miR-24-3p PCNA -0.26 0.0069 0.97 0 miRNAWalker2 validate -0.17 0.00324 NA
41 hsa-miR-26b-5p PCNA -1.11 0 0.97 0 miRNAWalker2 validate -0.27 0 NA
42 hsa-miR-30a-5p PCNA -0.63 0.00011 0.97 0 miRNAWalker2 validate -0.14 4.0E-5 NA
43 hsa-miR-542-3p PCNA -1.31 0 0.97 0 miRanda; miRNATAP -0.26 0 NA
44 hsa-miR-26b-5p POLA1 -1.11 0 0.83 0 miRNAWalker2 validate -0.2 2.0E-5 NA
45 hsa-let-7b-5p POLD2 -0.96 0 -0.1 0.35145 miRNAWalker2 validate -0.12 0.00017 NA
46 hsa-miR-107 POLD3 0.24 0.01708 0.49 0 MirTarget; miRanda -0.11 0.03127 NA
47 hsa-miR-29a-3p POLD3 -0.86 0 0.49 0 miRNAWalker2 validate -0.27 0 NA
48 hsa-miR-125a-3p POLD4 -0.84 4.0E-5 -0.06 0.63158 miRanda -0.1 0.00092 NA
49 hsa-miR-335-5p POLD4 -1.61 0 -0.06 0.63158 miRNAWalker2 validate -0.14 1.0E-5 NA
50 hsa-miR-590-5p POLD4 -0.1 0.31003 -0.06 0.63158 miRanda -0.14 0.0213 NA
51 hsa-miR-29a-3p POLE3 -0.86 0 0.2 0.00379 MirTarget -0.14 0 NA
52 hsa-miR-29c-3p POLE3 -1.44 0 0.2 0.00379 MirTarget -0.14 0 NA
53 hsa-let-7b-5p PRIM1 -0.96 0 1.3 0 miRNAWalker2 validate -0.3 0 NA
54 hsa-miR-125a-3p PRIM1 -0.84 4.0E-5 1.3 0 miRanda -0.13 0.00171 NA
55 hsa-miR-24-3p PRIM1 -0.26 0.0069 1.3 0 miRNAWalker2 validate -0.26 0.00383 NA
56 hsa-miR-30a-5p PRIM1 -0.63 0.00011 1.3 0 miRNAWalker2 validate -0.34 0 NA
57 hsa-miR-326 PRIM2 -1.88 0 1.37 0 miRanda -0.15 0 NA
58 hsa-miR-542-3p PRIM2 -1.31 0 1.37 0 MirTarget; miRanda -0.28 0 NA
59 hsa-miR-342-3p RFC1 -0.32 0.04498 0.44 0 miRanda -0.15 0 NA
60 hsa-miR-450b-5p RFC1 -1.34 0 0.44 0 MirTarget; PITA -0.15 0 NA
61 hsa-let-7a-3p RFC3 -0.57 0 0.96 0 MirTarget -0.17 0.00334 NA
62 hsa-let-7b-3p RFC3 -1.22 0 0.96 0 MirTarget -0.18 3.0E-5 NA
63 hsa-let-7f-1-3p RFC3 -0.7 0 0.96 0 MirTarget -0.15 0.00103 NA
64 hsa-miR-139-5p RFC3 -2.11 0 0.96 0 miRanda -0.18 0 NA
65 hsa-miR-181c-5p RFC3 -0.01 0.96913 0.96 0 MirTarget -0.1 0.00781 NA
66 hsa-miR-125b-5p RFC5 -1.36 0 0.43 2.0E-5 MirTarget -0.18 0 NA
67 hsa-miR-140-5p RFC5 -0.22 0.01407 0.43 2.0E-5 miRanda -0.12 0.03834 NA
68 hsa-miR-126-5p RPA1 -0.43 7.0E-5 0.1 0.17964 mirMAP -0.13 6.0E-5 NA
69 hsa-miR-139-5p RPS27A -2.11 0 0.32 0.00677 miRanda -0.15 0 NA
70 hsa-miR-140-5p RPS27A -0.22 0.01407 0.32 0.00677 miRanda -0.25 0.00014 NA
71 hsa-miR-26a-5p RPS27A -0.96 0 0.32 0.00677 miRNAWalker2 validate -0.18 0.00111 NA
72 hsa-miR-30c-5p RPS27A -0.43 0.00016 0.32 0.00677 miRNAWalker2 validate -0.12 0.01923 NA
73 hsa-miR-139-5p TOP2A -2.11 0 4.15 0 miRanda -0.96 0 26079880 We identified that miR-139 a previous reported anti-metastatic microRNA targets 3'-untranslated region 3'UTR of TOP2a mRNA; Further more we revealed that the forced expression of miR-139 reduces the TOP2a expression at both mRNA and protein levels; And our functional experiments showed that the ectopic expression of miR-139 remarkably inhibits proliferation in luminal type breast cancer cells while exogenous TOP2a expression could rescue inhibition of cell proliferation mediated by miR-139
74 hsa-miR-193b-3p TOP2A -0.17 0.27202 4.15 0 miRNAWalker2 validate -0.21 0.03823 NA
75 hsa-miR-542-3p TOP2A -1.31 0 4.15 0 miRanda -0.73 0 NA
76 hsa-let-7c-5p UBA52 -1.71 0 0.28 0.01101 miRNAWalker2 validate -0.11 0.00013 NA
77 hsa-miR-140-5p UBA52 -0.22 0.01407 0.28 0.01101 miRanda -0.18 0.00278 NA
78 hsa-miR-542-3p UBA52 -1.31 0 0.28 0.01101 miRanda -0.12 0.00113 NA
79 hsa-miR-590-3p UBA52 -0.47 2.0E-5 0.28 0.01101 miRanda; mirMAP -0.2 6.0E-5 NA
80 hsa-miR-148b-5p UBB 0.3 0.02557 -0.54 0 miRNAWalker2 validate -0.1 0.00488 NA
81 hsa-miR-181b-5p UBB 0.49 0.00105 -0.54 0 miRNAWalker2 validate -0.19 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 DNA REPLICATION 24 208 1.862e-45 8.665e-42
2 DNA DEPENDENT DNA REPLICATION 21 99 1.149e-44 2.674e-41
3 DNA METABOLIC PROCESS 27 758 2.675e-39 4.15e-36
4 CELL CYCLE PHASE TRANSITION 19 255 1.04e-30 1.21e-27
5 CELL CYCLE G1 S PHASE TRANSITION 16 111 3.251e-30 2.521e-27
6 G1 S TRANSITION OF MITOTIC CELL CYCLE 16 111 3.251e-30 2.521e-27
7 DNA REPLICATION INITIATION 12 29 1.046e-28 6.954e-26
8 NUCLEOTIDE EXCISION REPAIR DNA GAP FILLING 11 24 6.3e-27 3.664e-24
9 MITOTIC RECOMBINATION 12 41 1.579e-26 8.163e-24
10 TELOMERE MAINTENANCE VIA RECOMBINATION 11 32 3.237e-25 1.506e-22
11 CHROMOSOME ORGANIZATION 22 1009 1.478e-24 5.828e-22
12 DNA DAMAGE RESPONSE DETECTION OF DNA DAMAGE 11 36 1.503e-24 5.828e-22
13 NUCLEOTIDE EXCISION REPAIR DNA INCISION 11 39 4.184e-24 1.498e-21
14 TRANSLESION SYNTHESIS 11 41 7.875e-24 2.617e-21
15 MITOTIC CELL CYCLE 20 766 2.499e-23 7.753e-21
16 DNA SYNTHESIS INVOLVED IN DNA REPAIR 12 74 4.287e-23 1.247e-20
17 DNA BIOSYNTHETIC PROCESS 13 121 1.4e-22 3.832e-20
18 POSTREPLICATION REPAIR 11 54 2.363e-22 6.109e-20
19 DNA RECOMBINATION 14 215 3.184e-21 7.797e-19
20 TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR 11 73 8.664e-21 2.016e-18
21 CELL CYCLE PROCESS 20 1081 2.366e-20 5.241e-18
22 ERROR FREE TRANSLESION SYNTHESIS 8 19 2.622e-19 5.304e-17
23 ERROR PRONE TRANSLESION SYNTHESIS 8 19 2.622e-19 5.304e-17
24 TELOMERE ORGANIZATION 11 104 5.308e-19 1.029e-16
25 CELL CYCLE 20 1316 1.149e-18 2.138e-16
26 NUCLEOTIDE EXCISION REPAIR 11 113 1.374e-18 2.46e-16
27 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 17 720 1.435e-18 2.473e-16
28 DNA STRAND ELONGATION INVOLVED IN DNA REPLICATION 8 25 3.733e-18 6.204e-16
29 DNA GEOMETRIC CHANGE 10 81 5.327e-18 8.547e-16
30 DNA STRAND ELONGATION 8 30 2.012e-17 3.12e-15
31 NUCLEIC ACID PHOSPHODIESTER BOND HYDROLYSIS 12 254 1.993e-16 2.991e-14
32 DNA REPAIR 14 480 2.63e-16 3.824e-14
33 ANATOMICAL STRUCTURE HOMEOSTASIS 11 285 4.322e-14 6.094e-12
34 CELLULAR RESPONSE TO STRESS 17 1565 5.634e-13 7.71e-11
35 DNA CONFORMATION CHANGE 10 273 1.31e-12 1.741e-10
36 DETECTION OF STIMULUS 11 675 4.756e-10 6.147e-08
37 MISMATCH REPAIR 5 31 5.025e-10 6.319e-08
38 DNA INTEGRITY CHECKPOINT 6 146 3.561e-08 4.36e-06
39 NUCLEOTIDE EXCISION REPAIR PREINCISION COMPLEX ASSEMBLY 4 29 6.112e-08 7.292e-06
40 REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 6 162 6.618e-08 7.698e-06
41 CELL CYCLE CHECKPOINT 6 194 1.926e-07 2.186e-05
42 MITOTIC DNA INTEGRITY CHECKPOINT 5 100 2.09e-07 2.315e-05
43 INTERSTRAND CROSS LINK REPAIR 4 44 3.445e-07 3.728e-05
44 SINGLE ORGANISM BIOSYNTHETIC PROCESS 11 1340 5.621e-07 5.813e-05
45 HOMEOSTATIC PROCESS 11 1337 5.497e-07 5.813e-05
46 POSITIVE REGULATION OF CELL CYCLE PROCESS 6 247 7.953e-07 8.044e-05
47 MITOTIC CELL CYCLE CHECKPOINT 5 139 1.077e-06 0.0001066
48 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 5 147 1.42e-06 0.0001376
49 REGULATION OF MITOTIC CELL CYCLE 7 468 2.174e-06 0.0002064
50 REGULATION OF DNA REPLICATION 5 161 2.222e-06 0.0002068
51 G1 DNA DAMAGE CHECKPOINT 4 73 2.69e-06 0.0002454
52 NUCLEOTIDE EXCISION REPAIR DNA DUPLEX UNWINDING 3 22 3.322e-06 0.0002972
53 REGULATION OF CELL CYCLE PHASE TRANSITION 6 321 3.634e-06 0.000319
54 NUCLEOTIDE EXCISION REPAIR DNA DAMAGE RECOGNITION 3 23 3.816e-06 0.0003288
55 POSITIVE REGULATION OF DNA METABOLIC PROCESS 5 185 4.39e-06 0.0003665
56 POSITIVE REGULATION OF CELL CYCLE 6 332 4.411e-06 0.0003665
57 GLYCOGEN BIOSYNTHETIC PROCESS 3 25 4.947e-06 0.0003903
58 POSITIVE REGULATION OF CELL CYCLE ARREST 4 85 4.949e-06 0.0003903
59 GLUCAN BIOSYNTHETIC PROCESS 3 25 4.947e-06 0.0003903
60 REGULATION OF DNA METABOLIC PROCESS 6 340 5.057e-06 0.0003922
61 REGULATION OF NECROTIC CELL DEATH 3 26 5.588e-06 0.0004262
62 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 5 199 6.266e-06 0.0004639
63 REGULATION OF TRANSCRIPTION INVOLVED IN G1 S TRANSITION OF MITOTIC CELL CYCLE 3 27 6.28e-06 0.0004639
64 NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR SIGNALING PATHWAY 3 28 7.028e-06 0.0005109
65 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 4 96 8.037e-06 0.0005753
66 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 4 98 8.724e-06 0.0006058
67 MYD88 INDEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 3 30 8.694e-06 0.0006058
68 MYD88 DEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 3 32 1.06e-05 0.0007047
69 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR 3 32 1.06e-05 0.0007047
70 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA 3 32 1.06e-05 0.0007047
71 CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 3 33 1.165e-05 0.0007636
72 PROTEIN DNA COMPLEX SUBUNIT ORGANIZATION 5 229 1.238e-05 0.0008002
73 REGULATION OF CELL CYCLE ARREST 4 108 1.282e-05 0.0008174
74 POSITIVE REGULATION OF ERBB SIGNALING PATHWAY 3 36 1.521e-05 0.0009562
75 VIRION ASSEMBLY 3 37 1.653e-05 0.001026
76 ERBB2 SIGNALING PATHWAY 3 39 1.941e-05 0.001188
77 NEGATIVE REGULATION OF TYPE I INTERFERON PRODUCTION 3 40 2.097e-05 0.001267
78 REGULATION OF DNA DEPENDENT DNA REPLICATION 3 41 2.26e-05 0.001348
79 POLYSACCHARIDE BIOSYNTHETIC PROCESS 3 42 2.432e-05 0.001414
80 SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 4 127 2.43e-05 0.001414
81 NEGATIVE REGULATION OF ERBB SIGNALING PATHWAY 3 44 2.801e-05 0.001609
82 REGULATION OF TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 3 50 4.122e-05 0.002339
83 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 4 146 4.197e-05 0.002353
84 CELLULAR CARBOHYDRATE BIOSYNTHETIC PROCESS 3 51 4.376e-05 0.002424
85 CELLULAR GLUCAN METABOLIC PROCESS 3 58 6.443e-05 0.003486
86 GLUCAN METABOLIC PROCESS 3 58 6.443e-05 0.003486
87 DOUBLE STRAND BREAK REPAIR 4 165 6.76e-05 0.003615
88 REGULATION OF CELL CYCLE PROCESS 6 558 8.245e-05 0.004359
89 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 3 66 9.487e-05 0.004905
90 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 3 66 9.487e-05 0.004905
91 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 3 67 9.922e-05 0.005074
92 MULTI ORGANISM TRANSPORT 3 68 0.0001037 0.005189
93 MULTI ORGANISM LOCALIZATION 3 68 0.0001037 0.005189
94 POSITIVE REGULATION OF CATALYTIC ACTIVITY 9 1518 0.0001089 0.005392
95 I KAPPAB KINASE NF KAPPAB SIGNALING 3 70 0.0001131 0.005538
96 ENERGY RESERVE METABOLIC PROCESS 3 72 0.000123 0.005961
97 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 6 616 0.0001419 0.006807
98 ANAPHASE PROMOTING COMPLEX DEPENDENT CATABOLIC PROCESS 3 77 0.0001502 0.007129
99 ERBB SIGNALING PATHWAY 3 79 0.000162 0.007616
100 POLYSACCHARIDE METABOLIC PROCESS 3 80 0.0001682 0.007749
101 RECOMBINATIONAL REPAIR 3 80 0.0001682 0.007749
102 JNK CASCADE 3 82 0.000181 0.008256
103 REGULATION OF ERBB SIGNALING PATHWAY 3 83 0.0001876 0.008313
104 NEGATIVE REGULATION OF CELL CYCLE PROCESS 4 214 0.0001844 0.008313
105 NIK NF KAPPAB SIGNALING 3 83 0.0001876 0.008313
106 FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 3 84 0.0001944 0.008532
107 TOLL LIKE RECEPTOR SIGNALING PATHWAY 3 85 0.0002013 0.008754
108 REGULATION OF CELL CYCLE 7 949 0.000204 0.008788
NumGOOverlapSizeP ValueAdj. P Value
1 DNA DEPENDENT ATPASE ACTIVITY 7 79 9.526e-12 8.85e-09
2 DNA HELICASE ACTIVITY 6 53 7.334e-11 3.406e-08
3 DNA DIRECTED DNA POLYMERASE ACTIVITY 5 28 2.915e-10 8.137e-08
4 NUCLEOTIDYLTRANSFERASE ACTIVITY 7 131 3.504e-10 8.137e-08
5 HELICASE ACTIVITY 7 153 1.043e-09 1.938e-07
6 DNA POLYMERASE ACTIVITY 5 40 1.93e-09 2.988e-07
7 HYDROLASE ACTIVITY ACTING ON ACID ANHYDRIDES 11 820 3.677e-09 4.88e-07
8 ATPASE ACTIVITY COUPLED 7 313 1.46e-07 1.507e-05
9 SINGLE STRANDED DNA BINDING 5 93 1.452e-07 1.507e-05
10 ADENYL NUCLEOTIDE BINDING 12 1514 2.018e-07 1.874e-05
11 ATPASE ACTIVITY 7 427 1.182e-06 9.979e-05
12 RIBONUCLEOTIDE BINDING 12 1860 1.858e-06 0.0001439
13 ATP DEPENDENT DNA HELICASE ACTIVITY 3 34 1.277e-05 0.0009124
14 RNA POLYMERASE ACTIVITY 3 44 2.801e-05 0.001858
15 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 8 992 3.398e-05 0.002105
16 SINGLE STRANDED DNA DEPENDENT ATPASE ACTIVITY 2 13 0.0001356 0.007876
NumGOOverlapSizeP ValueAdj. P Value
1 REPLICATION FORK 13 62 1.232e-26 7.194e-24
2 CHROMOSOME 19 880 2.216e-20 6.383e-18
3 REPLISOME 9 29 3.279e-20 6.383e-18
4 MCM COMPLEX 7 11 1.151e-18 1.681e-16
5 NUCLEAR REPLICATION FORK 8 39 2.099e-16 2.451e-14
6 NUCLEAR CHROMOSOME 14 523 8.647e-16 8.417e-14
7 PROTEIN DNA COMPLEX 9 175 1.001e-12 8.348e-11
8 NUCLEAR CHROMOSOME TELOMERIC REGION 8 132 5.805e-12 4.238e-10
9 CHROMOSOME TELOMERIC REGION 8 162 3.033e-11 1.968e-09
10 CHROMOSOMAL REGION 8 330 8.529e-09 4.981e-07
11 DNA POLYMERASE COMPLEX 3 13 6.219e-07 3.302e-05
12 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 5 237 1.462e-05 0.0007113

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Cell_cycle_hsa04110 10 124 4.476e-16 2.327e-14

Quest ID: 45dad421ee0f1f10f05ec758eb4266d5