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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-30a-5p ABL2 -0.92 0.00076 0.31 0.01567 mirMAP; miRNATAP -0.11 0 NA
2 hsa-miR-30a-5p ADAM22 -0.92 0.00076 0.04 0.92539 MirTarget; miRNATAP -0.16 0.01239 NA
3 hsa-miR-30a-5p ADAMTS6 -0.92 0.00076 0.37 0.18207 MirTarget; miRNATAP -0.15 0.00099 NA
4 hsa-miR-30a-5p ALG10 -0.92 0.00076 0.64 5.0E-5 MirTarget -0.13 0 NA
5 hsa-miR-30a-5p ALG6 -0.92 0.00076 0.8 0 MirTarget -0.11 0 NA
6 hsa-miR-30a-5p AMMECR1 -0.92 0.00076 0.59 1.0E-5 miRNATAP -0.11 0 NA
7 hsa-miR-30a-5p ANTXR1 -0.92 0.00076 -0.82 0.00129 mirMAP -0.1 0.018 NA
8 hsa-miR-30a-5p ARL4A -0.92 0.00076 -0.32 0.06979 MirTarget -0.1 0.00042 NA
9 hsa-miR-30a-5p ARL4C -0.92 0.00076 0.66 0.00161 miRNATAP -0.12 0.00063 NA
10 hsa-miR-30a-5p ARL6IP6 -0.92 0.00076 0.14 0.36045 miRNATAP -0.13 0 NA
11 hsa-miR-30a-5p ATL2 -0.92 0.00076 0.61 3.0E-5 miRNAWalker2 validate; miRNATAP -0.1 2.0E-5 NA
12 hsa-miR-30a-5p ATL3 -0.92 0.00076 0.11 0.46975 mirMAP -0.11 1.0E-5 NA
13 hsa-miR-30a-5p ATP2A2 -0.92 0.00076 0.63 1.0E-5 miRNAWalker2 validate; mirMAP -0.16 0 NA
14 hsa-miR-30a-5p ATP6V1C1 -0.92 0.00076 0.29 0.00966 miRNAWalker2 validate -0.12 0 NA
15 hsa-miR-30a-5p ATP8B1 -0.92 0.00076 0.31 0.17188 miRNATAP -0.11 0.00311 NA
16 hsa-miR-30a-5p AVEN -0.92 0.00076 0.61 4.0E-5 miRNAWalker2 validate -0.16 0 23445407 At least one of these targets the anti-apoptotic protein AVEN was able to partially revert the effect of miR-30a overexpression
17 hsa-miR-30a-5p AVL9 -0.92 0.00076 0.94 0 MirTarget; mirMAP; miRNATAP -0.17 0 NA
18 hsa-miR-30a-5p AZIN1 -0.92 0.00076 0.34 0.00945 miRNATAP -0.14 0 NA
19 hsa-miR-30a-5p B3GNT5 -0.92 0.00076 -0.33 0.14374 MirTarget; miRNATAP -0.13 0.00065 NA
20 hsa-miR-30a-5p B4GALT1 -0.92 0.00076 0.36 0.02384 mirMAP -0.18 0 NA
21 hsa-miR-30a-5p BCL9 -0.92 0.00076 1.24 0 miRNATAP -0.18 0 NA
22 hsa-miR-30a-5p BEND3 -0.92 0.00076 0.58 0.00022 mirMAP; miRNATAP -0.12 0 NA
23 hsa-miR-30a-5p BMS1 -0.92 0.00076 0.42 5.0E-5 miRNAWalker2 validate -0.11 0 NA
24 hsa-miR-30a-5p BRAP -0.92 0.00076 0.19 0.03293 miRNATAP -0.1 0 NA
25 hsa-miR-30a-5p BRWD3 -0.92 0.00076 0.68 0.00035 MirTarget; miRNATAP -0.12 0.00016 NA
26 hsa-miR-30a-5p C16orf87 -0.92 0.00076 0.57 1.0E-5 miRNATAP -0.16 0 NA
27 hsa-miR-30a-5p C4orf46 -0.92 0.00076 0.7 1.0E-5 mirMAP -0.25 0 NA
28 hsa-miR-30a-5p CALU -0.92 0.00076 0.7 3.0E-5 MirTarget -0.25 0 NA
29 hsa-miR-30a-5p CAND1 -0.92 0.00076 0.38 0.00711 mirMAP -0.12 0 NA
30 hsa-miR-30a-5p CARS -0.92 0.00076 0.48 1.0E-5 miRNAWalker2 validate; MirTarget; miRNATAP -0.12 0 NA
31 hsa-miR-30a-5p CBX2 -0.92 0.00076 1.86 0 miRNATAP -0.4 0 NA
32 hsa-miR-30a-5p CBX3 -0.92 0.00076 1.01 0 MirTarget -0.22 0 NA
33 hsa-miR-30a-5p CCDC43 -0.92 0.00076 0.57 0 MirTarget -0.17 0 NA
34 hsa-miR-30a-5p CCNE2 -0.92 0.00076 2.15 0 miRNATAP -0.49 0 NA
35 hsa-miR-30a-5p CDC123 -0.92 0.00076 0.41 0.00055 miRNAWalker2 validate -0.1 0 NA
36 hsa-miR-30a-5p CDC20 -0.92 0.00076 3.63 0 miRNAWalker2 validate -0.66 0 NA
37 hsa-miR-30a-5p CDCA7 -0.92 0.00076 2.75 0 MirTarget -0.31 0 NA
38 hsa-miR-30a-5p CDH2 -0.92 0.00076 0.21 0.68235 miRNAWalker2 validate -0.38 1.0E-5 21633953 Consistent with this microRNA-30a expression was found inversely proportional to the invasive potential of various NSCLC cell lines correlating positively with E-cadherin epithelial marker and negatively with N-cadherin mesenchymal marker expression
39 hsa-miR-30a-5p CELF3 -0.92 0.00076 1.15 0.11981 MirTarget -0.48 0.0001 NA
40 hsa-miR-30a-5p CELSR3 -0.92 0.00076 3.19 0 MirTarget; miRNATAP -0.41 0 NA
41 hsa-miR-30a-5p CEP72 -0.92 0.00076 1.46 0 miRNAWalker2 validate -0.23 0 NA
42 hsa-miR-30a-5p CEP76 -0.92 0.00076 0.44 0.0025 MirTarget -0.12 0 NA
43 hsa-miR-30a-5p CHST1 -0.92 0.00076 -0.09 0.76687 MirTarget -0.2 0.0001 NA
44 hsa-miR-30a-5p CIT -0.92 0.00076 1.27 0.001 miRNATAP -0.18 0.00634 NA
45 hsa-miR-30a-5p CLDN12 -0.92 0.00076 1.02 0 mirMAP -0.12 2.0E-5 NA
46 hsa-miR-30a-5p CMC1 -0.92 0.00076 0.34 0.01376 mirMAP -0.12 0 NA
47 hsa-miR-30a-5p CNP -0.92 0.00076 0.68 0 miRNAWalker2 validate -0.14 0 NA
48 hsa-miR-30a-5p COL12A1 -0.92 0.00076 -0.85 0.03497 mirMAP -0.37 0 NA
49 hsa-miR-30a-5p COPS7B -0.92 0.00076 0.71 0 miRNAWalker2 validate; mirMAP; miRNATAP -0.1 0 NA
50 hsa-miR-30a-5p CPD -0.92 0.00076 0.91 9.0E-5 mirMAP -0.25 0 NA
51 hsa-miR-30a-5p CPLX1 -0.92 0.00076 0.63 0.05262 mirMAP -0.33 0 NA
52 hsa-miR-30a-5p CPOX -0.92 0.00076 0.87 0 miRNAWalker2 validate -0.13 0 NA
53 hsa-miR-30a-5p CPSF1 -0.92 0.00076 0.84 0 miRNAWalker2 validate -0.11 0.00011 NA
54 hsa-miR-30a-5p CPSF3 -0.92 0.00076 0.74 0 miRNAWalker2 validate -0.16 0 NA
55 hsa-miR-30a-5p CPSF4 -0.92 0.00076 0.7 0 miRNAWalker2 validate -0.14 0 NA
56 hsa-miR-30a-5p CPSF6 -0.92 0.00076 0.62 0 MirTarget; miRNATAP -0.11 0 NA
57 hsa-miR-30a-5p CTHRC1 -0.92 0.00076 3.35 0 MirTarget -0.65 0 NA
58 hsa-miR-30a-5p CUL2 -0.92 0.00076 0.19 0.08607 MirTarget; miRNATAP -0.11 0 NA
59 hsa-miR-30a-5p CYP24A1 -0.92 0.00076 5.26 0 miRNATAP -0.69 0 NA
60 hsa-miR-30a-5p DARS2 -0.92 0.00076 1.03 0 miRNAWalker2 validate -0.24 0 NA
61 hsa-miR-30a-5p DBF4 -0.92 0.00076 1.26 0 MirTarget -0.32 0 NA
62 hsa-miR-30a-5p DDX10 -0.92 0.00076 0.39 0.00203 miRNAWalker2 validate -0.13 0 NA
63 hsa-miR-30a-5p DDX52 -0.92 0.00076 0.67 0 mirMAP -0.13 0 NA
64 hsa-miR-30a-5p DERL1 -0.92 0.00076 0.12 0.24598 miRNAWalker2 validate -0.12 0 NA
65 hsa-miR-30a-5p DHX33 -0.92 0.00076 0.21 0.19056 miRNAWalker2 validate -0.11 5.0E-5 NA
66 hsa-miR-30a-5p DHX36 -0.92 0.00076 0.08 0.48345 miRNAWalker2 validate -0.11 0 NA
67 hsa-miR-30a-5p DIO2 -0.92 0.00076 1.92 0 mirMAP; miRNATAP -0.47 0 NA
68 hsa-miR-30a-5p DLG5 -0.92 0.00076 1.13 0 miRNATAP -0.11 0.00011 NA
69 hsa-miR-30a-5p DLGAP4 -0.92 0.00076 0.27 0.02041 MirTarget; miRNATAP -0.11 0 NA
70 hsa-miR-30a-5p DNAJA1 -0.92 0.00076 -0.13 0.31726 miRNAWalker2 validate -0.13 0 NA
71 hsa-miR-30a-5p DNAJC2 -0.92 0.00076 0.82 0 miRNAWalker2 validate -0.18 0 NA
72 hsa-miR-30a-5p DNMT3A -0.92 0.00076 1.2 0 MirTarget; miRNATAP -0.24 0 NA
73 hsa-miR-30a-5p DPY19L1 -0.92 0.00076 0.84 8.0E-5 miRNAWalker2 validate; miRNATAP -0.14 6.0E-5 NA
74 hsa-miR-30a-5p DRP2 -0.92 0.00076 2.45 0 mirMAP -0.65 0 NA
75 hsa-miR-30a-5p DSG2 -0.92 0.00076 0.96 0.00021 miRNAWalker2 validate; MirTarget -0.1 0.01959 NA
76 hsa-miR-30a-5p DSP -0.92 0.00076 2.27 0 MirTarget -0.37 0 NA
77 hsa-miR-30a-5p DTL -0.92 0.00076 1.88 0 miRNAWalker2 validate; miRTarBase -0.4 0 22287560 MiR 30a 5p suppresses tumor growth in colon carcinoma by targeting DTL; Subsequent reporter gene assays confirmed the predicted miR-30a-5p binding site in the 3'untranslated region of DTL; In conclusion our data identified miR-30a-5p as a tumor-suppressing miRNA in colon cancer cells exerting its function via modulation of DTL expression which is frequently overexpressed in colorectal cancer
78 hsa-miR-30a-5p E2F3 -0.92 0.00076 1.31 0 miRNATAP -0.21 0 NA
79 hsa-miR-30a-5p E2F7 -0.92 0.00076 2.4 0 miRNATAP -0.33 0 NA
80 hsa-miR-30a-5p EED -0.92 0.00076 0.65 0 MirTarget; miRNATAP -0.15 0 NA
81 hsa-miR-30a-5p EFNA3 -0.92 0.00076 2.4 0 MirTarget; mirMAP; miRNATAP -0.32 0 NA
82 hsa-miR-30a-5p EIF2AK2 -0.92 0.00076 0.62 9.0E-5 mirMAP -0.15 0 NA
83 hsa-miR-30a-5p EIF2B1 -0.92 0.00076 0.35 0.0002 miRNAWalker2 validate -0.12 0 NA
84 hsa-miR-30a-5p EIF5A2 -0.92 0.00076 -0.01 0.97137 mirMAP; miRNATAP -0.11 0.00111 NA
85 hsa-miR-30a-5p ELMOD2 -0.92 0.00076 0.46 6.0E-5 miRNAWalker2 validate; MirTarget; miRNATAP -0.1 0 NA
86 hsa-miR-30a-5p ENPP1 -0.92 0.00076 0.22 0.5129 mirMAP -0.26 0 NA
87 hsa-miR-30a-5p ERRFI1 -0.92 0.00076 0.44 0.10678 MirTarget -0.17 0.00017 NA
88 hsa-miR-30a-5p ESPN -0.92 0.00076 2.31 0 MirTarget; miRNATAP -0.32 3.0E-5 NA
89 hsa-miR-30a-5p FAM104A -0.92 0.00076 0.38 3.0E-5 MirTarget -0.13 0 NA
90 hsa-miR-30a-5p FAM126A -0.92 0.00076 0.13 0.58359 mirMAP -0.14 0.0003 NA
91 hsa-miR-30a-5p FAM196A -0.92 0.00076 0.36 0.37 MirTarget; miRNATAP -0.18 0.00617 NA
92 hsa-miR-30a-5p FAM199X -0.92 0.00076 0.79 0 mirMAP; miRNATAP -0.15 0 NA
93 hsa-miR-30a-5p FAM69A -0.92 0.00076 0.75 1.0E-5 MirTarget -0.11 0.00018 NA
94 hsa-miR-30a-5p FAM91A1 -0.92 0.00076 0.6 0 MirTarget -0.15 0 NA
95 hsa-miR-30a-5p FAP -0.92 0.00076 1.77 0 miRNATAP -0.35 0 NA
96 hsa-miR-30a-5p FBXL20 -0.92 0.00076 0.58 7.0E-5 miRNATAP -0.1 2.0E-5 NA
97 hsa-miR-30a-5p FBXO45 -0.92 0.00076 0.67 2.0E-5 miRNATAP -0.21 0 NA
98 hsa-miR-30a-5p FGF5 -0.92 0.00076 1.42 0.00664 mirMAP -0.46 0 NA
99 hsa-miR-30a-5p FKBP3 -0.92 0.00076 0.93 0 MirTarget -0.22 0 NA
100 hsa-miR-30a-5p FLVCR1 -0.92 0.00076 1.37 0 MirTarget -0.23 0 NA
101 hsa-miR-30a-5p FNDC3B -0.92 0.00076 0.22 0.12432 miRNAWalker2 validate; miRNATAP -0.11 1.0E-5 NA
102 hsa-miR-30a-5p FOXA1 -0.92 0.00076 1.08 0.00032 miRNATAP -0.41 0 NA
103 hsa-miR-30a-5p FOXP2 -0.92 0.00076 -0.82 0.04073 mirMAP -0.16 0.02004 NA
104 hsa-miR-30a-5p FZD3 -0.92 0.00076 0.79 0.00088 MirTarget; miRNATAP -0.21 0 NA
105 hsa-miR-30a-5p GALNT7 -0.92 0.00076 1.46 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.14 4.0E-5 NA
106 hsa-miR-30a-5p GATC -0.92 0.00076 0.23 0.19835 miRNAWalker2 validate -0.16 0 NA
107 hsa-miR-30a-5p GCH1 -0.92 0.00076 0.08 0.67135 mirMAP -0.17 0 NA
108 hsa-miR-30a-5p GFPT2 -0.92 0.00076 -0.71 0.0142 MirTarget; miRNATAP -0.16 0.00123 NA
109 hsa-miR-30a-5p GGCT -0.92 0.00076 1.58 0 miRNAWalker2 validate -0.22 0 NA
110 hsa-miR-30a-5p GLDC -0.92 0.00076 1.59 0.0024 MirTarget; miRNATAP -0.48 0 NA
111 hsa-miR-30a-5p GLRX3 -0.92 0.00076 0.76 0 miRNAWalker2 validate -0.13 0 NA
112 hsa-miR-30a-5p GMEB2 -0.92 0.00076 0.23 0.05926 MirTarget; miRNATAP -0.1 0 NA
113 hsa-miR-30a-5p GORASP2 -0.92 0.00076 0.7 0 miRNATAP -0.14 0 NA
114 hsa-miR-30a-5p GPR180 -0.92 0.00076 0.52 0.00037 mirMAP -0.15 0 NA
115 hsa-miR-30a-5p GRHL2 -0.92 0.00076 0.7 0.00242 miRNATAP -0.1 0.00751 NA
116 hsa-miR-30a-5p GTF2E2 -0.92 0.00076 0.57 2.0E-5 miRNATAP -0.13 0 NA
117 hsa-miR-30a-5p HDAC2 -0.92 0.00076 0.48 0.00021 mirMAP -0.14 0 NA
118 hsa-miR-30a-5p HDGF -0.92 0.00076 0.95 0 miRNAWalker2 validate -0.22 0 NA
119 hsa-miR-30a-5p HMGB3 -0.92 0.00076 2.91 0 miRNATAP -0.65 0 NA
120 hsa-miR-30a-5p HOXA11 -0.92 0.00076 1.33 0.02898 miRNATAP -0.41 5.0E-5 NA
121 hsa-miR-30a-5p HOXB8 -0.92 0.00076 0.5 0.46283 miRNATAP -0.47 4.0E-5 NA
122 hsa-miR-30a-5p HS2ST1 -0.92 0.00076 0.16 0.27392 mirMAP -0.11 1.0E-5 NA
123 hsa-miR-30a-5p HSPA5 -0.92 0.00076 0.82 0 miRNATAP -0.15 0 NA
124 hsa-miR-30a-5p HTRA3 -0.92 0.00076 0.53 0.0926 miRNATAP -0.31 0 NA
125 hsa-miR-30a-5p IFRD1 -0.92 0.00076 0.35 0.07398 miRNAWalker2 validate -0.2 0 NA
126 hsa-miR-30a-5p IKBIP -0.92 0.00076 0.08 0.59742 miRNAWalker2 validate; MirTarget -0.14 0 NA
127 hsa-miR-30a-5p IL1RAPL2 -0.92 0.00076 2.45 0 MirTarget -0.26 0.0037 NA
128 hsa-miR-30a-5p INHBA -0.92 0.00076 -0.96 0.00524 mirMAP -0.29 0 NA
129 hsa-miR-30a-5p IPMK -0.92 0.00076 -0.02 0.93735 mirMAP; miRNATAP -0.11 0.0099 NA
130 hsa-miR-30a-5p JAG2 -0.92 0.00076 0.03 0.91715 miRNATAP -0.19 0 NA
131 hsa-miR-30a-5p KCND2 -0.92 0.00076 1.52 0.00037 mirMAP -0.7 0 NA
132 hsa-miR-30a-5p KCTD5 -0.92 0.00076 0.56 3.0E-5 miRNATAP -0.11 0 NA
133 hsa-miR-30a-5p KIAA1549 -0.92 0.00076 0.45 0.10267 miRNATAP -0.11 0.02172 NA
134 hsa-miR-30a-5p KIF11 -0.92 0.00076 2.52 0 miRNAWalker2 validate; MirTarget -0.48 0 NA
135 hsa-miR-128-3p KLF4 1.04 0 -2.55 0 miRNAWalker2 validate; MirTarget -0.24 0.01045 NA
136 hsa-miR-135b-5p KLF4 3.25 0 -2.55 0 miRNAWalker2 validate; MirTarget -0.11 0.00341 NA
137 hsa-miR-148a-3p KLF4 2.31 0 -2.55 0 MirTarget; miRNATAP -0.29 0 NA
138 hsa-miR-200b-3p KLF4 1.55 0 -2.55 0 MirTarget; TargetScan -0.19 0.00094 NA
139 hsa-miR-29b-3p KLF4 3.11 0 -2.55 0 MirTarget; miRNATAP -0.17 0.0016 22751119 Progestin suppression of miR 29 potentiates dedifferentiation of breast cancer cells via KLF4; We demonstrate that miR-29 directly targets Krüppel-like factor 4 KLF4 a transcription factor required for the reprogramming of differentiated cells to pluripotent stem cells and for the maintenance of breast cancer stem cells; These results reveal a novel mechanism whereby progestins increase the stem cell-like population in hormone-responsive breast cancers by decreasing miR-29 to augment PR-mediated upregulation of KLF4
140 hsa-miR-301a-3p KLF4 2.7 0 -2.55 0 miRNATAP -0.32 0 NA
141 hsa-miR-30b-5p KLF4 0.36 0.13803 -2.55 0 miRNAWalker2 validate -0.17 0.00836 NA
142 hsa-miR-429 KLF4 2.38 0 -2.55 0 MirTarget; PITA; miRanda; miRNATAP -0.22 1.0E-5 NA
143 hsa-miR-92b-3p KLF4 0.05 0.83172 -2.55 0 MirTarget; miRNATAP -0.23 0.00061 NA
144 hsa-miR-30a-5p KPNA4 -0.92 0.00076 -0.01 0.93016 miRNAWalker2 validate; mirMAP -0.11 0 NA
145 hsa-miR-30a-5p KRAS -0.92 0.00076 0.54 0.00142 mirMAP; miRNATAP -0.16 0 NA
146 hsa-miR-30a-5p KSR1 -0.92 0.00076 0.25 0.33039 MirTarget -0.11 0.01192 NA
147 hsa-miR-30a-5p LARP1 -0.92 0.00076 0.42 0.0011 miRNATAP -0.1 0 NA
148 hsa-miR-30a-5p LARP4 -0.92 0.00076 0.16 0.18031 miRNAWalker2 validate; mirMAP; miRNATAP -0.12 0 NA
149 hsa-miR-30a-5p LCLAT1 -0.92 0.00076 0.68 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.16 0 NA
150 hsa-miR-30a-5p LGSN -0.92 0.00076 3.19 2.0E-5 mirMAP -0.59 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELL CYCLE PHASE TRANSITION 17 255 3.033e-06 0.003937
2 EMBRYO DEVELOPMENT 36 894 3.521e-06 0.003937
3 CELL CYCLE G1 S PHASE TRANSITION 11 111 4.23e-06 0.003937
4 EMBRYONIC MORPHOGENESIS 27 539 1.21e-06 0.003937
5 G1 S TRANSITION OF MITOTIC CELL CYCLE 11 111 4.23e-06 0.003937
6 NEUROGENESIS 48 1402 7.162e-06 0.005554
NumGOOverlapSizeP ValueAdj. P Value
1 RNA BINDING 62 1598 2.641e-09 2.453e-06
2 POLY A RNA BINDING 47 1170 1.058e-07 4.917e-05
3 ENZYME BINDING 60 1737 3.134e-07 9.706e-05
4 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING 8 53 3.779e-06 0.0008776
5 RIBONUCLEOTIDE BINDING 58 1860 1.243e-05 0.002309
6 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 9 86 2.043e-05 0.003163
7 RNA POLYMERASE II TRANSCRIPTION COACTIVATOR ACTIVITY 6 36 3.552e-05 0.004714
8 IDENTICAL PROTEIN BINDING 41 1209 4.399e-05 0.005109
9 CORE PROMOTER BINDING 11 152 8.16e-05 0.00758
10 UBIQUITIN LIKE PROTEIN LIGASE BINDING 15 264 7.377e-05 0.00758
11 HISTONE DEACETYLASE BINDING 9 105 9.967e-05 0.008418
12 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 10 133 0.0001248 0.009658
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa03015_mRNA_surveillance_pathway 10 83 1.954e-06 0.0003516
2 hsa04110_Cell_cycle 10 128 9.061e-05 0.008155
3 hsa03013_RNA_transport 10 152 0.0003696 0.02218
4 hsa04120_Ubiquitin_mediated_proteolysis 9 139 0.0008073 0.02913
5 hsa04141_Protein_processing_in_endoplasmic_reticulum 10 168 0.0008092 0.02913
6 hsa00520_Amino_sugar_and_nucleotide_sugar_metabolism 5 48 0.001511 0.04532
7 hsa03008_Ribosome_biogenesis_in_eukaryotes 6 81 0.003052 0.07849
8 hsa04114_Oocyte_meiosis 7 114 0.004063 0.09141
9 hsa03060_Protein_export 3 23 0.007372 0.1474
10 hsa00510_N.Glycan_biosynthesis 4 49 0.01072 0.193
11 hsa04350_TGF.beta_signaling_pathway 5 85 0.01712 0.2801
12 hsa03410_Base_excision_repair 3 34 0.02162 0.3243
13 hsa00230_Purine_metabolism 7 162 0.02482 0.3437
14 hsa00533_Glycosaminoglycan_biosynthesis_._keratan_sulfate 2 15 0.02788 0.3585
15 hsa03050_Proteasome 3 45 0.04456 0.5347
16 hsa04390_Hippo_signaling_pathway 6 154 0.05521 0.6143
17 hsa04014_Ras_signaling_pathway 8 236 0.05802 0.6143
18 hsa04012_ErbB_signaling_pathway 4 87 0.06751 0.6751
19 hsa00534_Glycosaminoglycan_biosynthesis_._heparan_sulfate 2 26 0.07611 0.677
20 hsa00601_Glycosphingolipid_biosynthesis_._lacto_and_neolacto_series 2 26 0.07611 0.677
21 hsa00562_Inositol_phosphate_metabolism 3 57 0.07898 0.677
22 hsa03020_RNA_polymerase 2 29 0.09191 0.7014
23 hsa04151_PI3K_AKT_signaling_pathway 10 351 0.09294 0.7014
24 hsa04910_Insulin_signaling_pathway 5 138 0.09703 0.7014
25 hsa00240_Pyrimidine_metabolism 4 99 0.09741 0.7014
26 hsa04730_Long.term_depression 3 70 0.1257 0.8184
27 hsa03018_RNA_degradation 3 71 0.1296 0.8184
28 hsa00051_Fructose_and_mannose_metabolism 2 36 0.1319 0.8184
29 hsa03030_DNA_replication 2 36 0.1319 0.8184
30 hsa04664_Fc_epsilon_RI_signaling_pathway 3 79 0.1626 0.9646
31 hsa00564_Glycerophospholipid_metabolism 3 80 0.1669 0.9646
32 hsa04722_Neurotrophin_signaling_pathway 4 127 0.1857 0.9646
33 hsa03420_Nucleotide_excision_repair 2 45 0.1876 0.9646
34 hsa00514_Other_types_of_O.glycan_biosynthesis 2 46 0.194 0.9698
35 hsa04330_Notch_signaling_pathway 2 47 0.2004 0.9748
36 hsa04540_Gap_junction 3 90 0.2113 0.9849
37 hsa00480_Glutathione_metabolism 2 50 0.2197 0.9849
38 hsa04150_mTOR_signaling_pathway 2 52 0.2327 0.9849
39 hsa00330_Arginine_and_proline_metabolism 2 54 0.2458 0.9849
40 hsa00500_Starch_and_sucrose_metabolism 2 54 0.2458 0.9849
41 hsa04912_GnRH_signaling_pathway 3 101 0.2627 0.9849
42 hsa04310_Wnt_signaling_pathway 4 151 0.2756 0.9849
43 hsa04145_Phagosome 4 156 0.2952 0.9849
44 hsa00970_Aminoacyl.tRNA_biosynthesis 2 63 0.3046 0.9849
45 hsa04810_Regulation_of_actin_cytoskeleton 5 214 0.325 0.9849
46 hsa04920_Adipocytokine_signaling_pathway 2 68 0.337 0.9849
47 hsa04115_p53_signaling_pathway 2 69 0.3434 0.9849
48 hsa04720_Long.term_potentiation 2 70 0.3498 0.9849
49 hsa04520_Adherens_junction 2 73 0.3689 0.9849
50 hsa04370_VEGF_signaling_pathway 2 76 0.3877 0.9849
51 hsa03040_Spliceosome 3 128 0.3922 0.9849
52 hsa04260_Cardiac_muscle_contraction 2 77 0.3939 0.9849
53 hsa04612_Antigen_processing_and_presentation 2 78 0.4001 0.9849
54 hsa04360_Axon_guidance 3 130 0.4017 0.9849
55 hsa00190_Oxidative_phosphorylation 3 132 0.4111 0.9849
56 hsa04530_Tight_junction 3 133 0.4158 0.9849
57 hsa04914_Progesterone.mediated_oocyte_maturation 2 87 0.4545 1
58 hsa04666_Fc_gamma_R.mediated_phagocytosis 2 95 0.5004 1
59 hsa04010_MAPK_signaling_pathway 5 268 0.5105 1
60 hsa04916_Melanogenesis 2 101 0.5331 1
61 hsa04972_Pancreatic_secretion 2 101 0.5331 1
62 hsa04270_Vascular_smooth_muscle_contraction 2 116 0.6084 1
63 hsa04020_Calcium_signaling_pathway 2 177 0.8213 1
64 hsa04510_Focal_adhesion 2 200 0.8698 1

Quest ID: 4b38288a3deff3a8c1ff4865341ea323