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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-140-3p KRAS -1.26 0 0.47 0 MirTarget -0.25 0 NA
2 hsa-miR-143-3p KRAS -1.23 0 0.47 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.12 0 22804917; 27725862; 19137007; 26581910; 23173124; 26824186; 21197560 In KRAS mutated tumours increased miR-200b and decreased miR-143 expression were associated with a good PFS;The expression of miR-143 is often down-regulated and it might play an important role by targeting KRAS in colorectal cancer CRC; Dual-luciferase reporter assays were performed to validate whether KRAS was regulated by miR-143; Dual-luciferase assays indicated that KRAS was a direct target of miR-143 as subsequently demonstrated by qPCR and western blot analysis showing that infection of SW480 cells with Ad-ZD55-miR-143 resulted in the down-regulation of KRAS at both mRNA and protein levels;Role of miR 143 targeting KRAS in colorectal tumorigenesis; In particular among a panel of presumed targets generated by in silico analysis that may interact with these aberrantly expressed miRNAs KRAS oncogene has been further experimentally validated as the target of miR-143; First an inverse correlation between KRAS protein and miR-143 in vivo was found; Second KRAS expression in Lovo cells was significantly abolished by treatment with miR-143 mimic whereas miR-143 inhibitor increased KRAS protein level; Third luciferase reporter assay confirmed that miR-143 directly recognize the 3'-untranslated region of KRAS transcripts; Finally inhibition of KRAS expression by miR-143 inhibits constitutive phosphorylation of ERK1/2; Taken together the present study provides the first evidences that miR-143 is significant in suppressing colorectal cancer cell growth through inhibition of KRAS translation;MicroRNA 143 replenishment re sensitizes colorectal cancer cells harboring mutant but not wild type KRAS to paclitaxel treatment; Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS; Combination of miR-143 mimic and paclitaxel induced the onset of apoptosis and reverted in vitro metastatic properties migration and invasion in KRAS mutant tumor cells; MiR-143 thus can be used as a chemosensitizer for the treatment of KRAS mutant tumors and warrants further investigations in in vitro and pre-clinical in vivo models;In turn the level of miR-143 in CRC cells decreasing the amount of MACC1 metastasis-associated in colon cancer-1 and oncogenic KRAS protein may be utilized as a prognostic marker;Stable miR-143 or miR-145 overexpression increased cell sensitivity to cetuximab resulting in a significant increase of cetuximab-mediated ADCC independently of KRAS status;miR 143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS; The expression level of miR-143 and its target gene KRAS were measured by realtime PCR and western blotting respectively; Our results revealed an inverse correlation of expression between miR-143 and KRAS protein in prostate cancer samples Pearson's correlation scatter plots: R = -0.707 P < 0.05; These findings suggest that miR-143 plays an important role in prostate cancer proliferation migration and chemosensitivity by suppressing KRAS and subsequent inactivation of MAPK pathway which provides a potential development of a new approach for the treatment of prostate cancer
3 hsa-miR-181a-5p KRAS 0.64 0 0.47 0 miRNAWalker2 validate -0.09 0.00098 24098024; 27517749; 26124189 The KRAS mutational status was determined by pyrosequencing and miR-181a expression was measured by quantitative RT-PCR in CRC tumour tissue and corresponding non-neoplastic colon tissue;Here we report that miR-181a directly binds to 3'-untranslated regions UTRs; downregulates KRAS NRAS and MAPK1; and decreases AML growth; The delivery of miR-181a mimics to target AML cells using transferrin-targeting lipopolyplex nanoparticles NP increased mature miR-181a; downregulated KRAS NRAS and MAPK1; and resulted in decreased phosphorylation of the downstream RAS effectors;MiR 181a 5p inhibits cell proliferation and migration by targeting Kras in non small cell lung cancer A549 cells; Luciferase activity assay results demonstrated that two binding sites of Kras could be directly targeted by miR-181a-5p; Furthermore Kras was down-regulated by miR-181a-5p at both transcriptional and translational levels; SiRNA-mediated Kras down-regulation could mimic the effects of miR-181a-5p mimic in A549 cells; Our findings suggest that miR-181a-5p plays a potential role in tumor suppression by partially targeting Kras and has the potential therapeutic application in NSCLC patients
4 hsa-miR-195-3p KRAS -1.5 0 0.47 0 mirMAP -0.14 0 NA
5 hsa-miR-199b-5p KRAS -1.37 0 0.47 0 miRanda; miRNATAP -0.07 0.00011 27517624 The miR-199b prognostic impact was particularly evident in both younger and KRAS wild-type subgroups
6 hsa-miR-217 KRAS -0.62 9.0E-5 0.47 0 miRNAWalker2 validate; miRTarBase; MirTarget; PITA; miRanda; miRNATAP -0.05 0.00138 25234467; 26062553 The overexpression of miR-217 significantly inhibited the proliferation migration and invasion as well as promoted the apoptosis of lung cancer cells by targeting KRAS; In conclusion miR-217 suppresses tumour development in lung cancer by targeting KRAS and enhances cell sensitivity to cisplatin;Quercetin Enhances Cisplatin Sensitivity of Human Osteosarcoma Cells by Modulating microRNA 217 KRAS Axis; Expression of miR-217 was upregulated after quercetin and/or cisplatin treatment while its target KRAS was downregulated both at mRNA and protein levels
7 hsa-miR-30b-5p KRAS -0.47 2.0E-5 0.47 0 mirMAP; miRNATAP -0.08 0.00072 NA
8 hsa-miR-30d-5p KRAS -0.25 0.00407 0.47 0 mirMAP; miRNATAP -0.13 1.0E-5 NA
9 hsa-miR-335-3p KRAS -1.88 0 0.47 0 mirMAP -0.06 0.00033 NA
10 hsa-miR-495-3p KRAS -1.68 0 0.47 0 mirMAP -0.05 0.00419 NA
11 hsa-miR-542-3p KRAS 0.57 0 0.47 0 miRanda -0.12 0 NA
12 hsa-miR-584-5p KRAS -1.75 0 0.47 0 MirTarget -0.05 0.00156 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 INTRACELLULAR SIGNAL TRANSDUCTION 182 1572 1.533e-38 7.131e-35
2 REGULATION OF CELL DEATH 164 1472 1.858e-32 4.322e-29
3 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 174 1656 2.336e-31 3.623e-28
4 POSITIVE REGULATION OF MOLECULAR FUNCTION 182 1791 4.875e-31 5.671e-28
5 RESPONSE TO OXYGEN CONTAINING COMPOUND 148 1381 2.378e-27 2.213e-24
6 REGULATION OF PROTEIN MODIFICATION PROCESS 169 1710 2.867e-27 2.224e-24
7 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 177 1848 5.208e-27 3.462e-24
8 POSITIVE REGULATION OF CATALYTIC ACTIVITY 156 1518 6.896e-27 4.011e-24
9 REGULATION OF PHOSPHORUS METABOLIC PROCESS 162 1618 1.053e-26 5.443e-24
10 POSITIVE REGULATION OF RESPONSE TO STIMULUS 181 1929 1.383e-26 6.435e-24
11 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 146 1395 6.598e-26 2.791e-23
12 REGULATION OF KINASE ACTIVITY 102 776 1.641e-25 6.364e-23
13 POSITIVE REGULATION OF CELL COMMUNICATION 152 1532 1.414e-24 5.061e-22
14 PROTEIN PHOSPHORYLATION 111 944 1.156e-23 3.842e-21
15 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 158 1672 2.387e-23 7.405e-21
16 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 146 1492 5.527e-23 1.607e-20
17 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 175 1977 8.78e-23 2.403e-20
18 REGULATION OF TRANSFERASE ACTIVITY 109 946 1.56e-22 4.033e-20
19 REGULATION OF HYDROLASE ACTIVITY 134 1327 2.726e-22 6.342e-20
20 REGULATION OF RESPONSE TO STRESS 143 1468 2.605e-22 6.342e-20
21 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 72 470 4.854e-22 1.075e-19
22 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 162 1805 1.274e-21 2.695e-19
23 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 112 1036 6.359e-21 1.2e-18
24 POSITIVE REGULATION OF GENE EXPRESSION 156 1733 6.447e-21 1.2e-18
25 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 112 1036 6.359e-21 1.2e-18
26 REGULATION OF CELLULAR RESPONSE TO STRESS 87 691 1.42e-20 2.541e-18
27 POSITIVE REGULATION OF HYDROLASE ACTIVITY 102 905 2.136e-20 3.681e-18
28 REGULATION OF CELL DIFFERENTIATION 140 1492 2.454e-20 4.078e-18
29 REGULATION OF CELL PROLIFERATION 140 1496 3.129e-20 5.02e-18
30 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 117 1142 5.904e-20 9.157e-18
31 PHOSPHORYLATION 122 1228 1.06e-19 1.59e-17
32 REGULATION OF MAPK CASCADE 83 660 1.252e-19 1.821e-17
33 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 93 799 1.386e-19 1.954e-17
34 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 130 1360 1.498e-19 2.05e-17
35 NEGATIVE REGULATION OF CELL DEATH 98 872 1.581e-19 2.102e-17
36 REGULATION OF MAP KINASE ACTIVITY 55 319 1.79e-19 2.314e-17
37 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 115 1135 3.059e-19 3.847e-17
38 POSITIVE REGULATION OF CELL DEATH 78 605 3.881e-19 4.752e-17
39 REGULATION OF GTPASE ACTIVITY 83 673 4.254e-19 5.075e-17
40 CELLULAR RESPONSE TO STRESS 141 1565 6.802e-19 7.913e-17
41 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 96 876 2.157e-18 2.448e-16
42 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 114 1152 2.723e-18 3.016e-16
43 POSITIVE REGULATION OF CELL DIFFERENTIATION 92 823 3.247e-18 3.513e-16
44 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 77 616 4.08e-18 4.315e-16
45 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 102 983 7.948e-18 8.218e-16
46 NEGATIVE REGULATION OF KINASE ACTIVITY 46 250 1.269e-17 1.283e-15
47 NEGATIVE REGULATION OF CELL COMMUNICATION 115 1192 1.301e-17 1.288e-15
48 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 108 1087 1.792e-17 1.737e-15
49 CELL DEVELOPMENT 129 1426 2.015e-17 1.913e-15
50 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 150 1784 2.326e-17 2.165e-15
51 RESPONSE TO INORGANIC SUBSTANCE 65 479 3.148e-17 2.872e-15
52 TISSUE DEVELOPMENT 134 1518 3.286e-17 2.94e-15
53 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 54 351 7.1e-17 6.233e-15
54 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 101 1004 9.763e-17 8.413e-15
55 RESPONSE TO ABIOTIC STIMULUS 102 1024 1.322e-16 1.119e-14
56 REGULATION OF IMMUNE SYSTEM PROCESS 125 1403 2.264e-16 1.882e-14
57 NEGATIVE REGULATION OF MOLECULAR FUNCTION 104 1079 6.087e-16 4.969e-14
58 POSITIVE REGULATION OF KINASE ACTIVITY 63 482 6.198e-16 4.972e-14
59 POSITIVE REGULATION OF MAPK CASCADE 62 470 6.862e-16 5.411e-14
60 RESPONSE TO EXTERNAL STIMULUS 148 1821 7.605e-16 5.897e-14
61 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 47 289 8.56e-16 6.529e-14
62 NEGATIVE REGULATION OF PHOSPHORYLATION 58 422 9.599e-16 7.204e-14
63 RESPONSE TO NITROGEN COMPOUND 89 859 1.342e-15 9.911e-14
64 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 99 1021 2.26e-15 1.643e-13
65 RESPONSE TO ENDOGENOUS STIMULUS 125 1450 2.79e-15 1.997e-13
66 NEUROGENESIS 122 1402 3.203e-15 2.258e-13
67 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 86 829 3.928e-15 2.728e-13
68 RESPONSE TO GROWTH FACTOR 61 475 4.175e-15 2.857e-13
69 RESPONSE TO CYTOKINE 78 714 5.138e-15 3.465e-13
70 EPITHELIUM DEVELOPMENT 93 945 7.089e-15 4.712e-13
71 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 65 541 1.296e-14 8.374e-13
72 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 65 541 1.296e-14 8.374e-13
73 IMMUNE SYSTEM PROCESS 153 1984 2.023e-14 1.29e-12
74 INTERSPECIES INTERACTION BETWEEN ORGANISMS 73 662 2.525e-14 1.566e-12
75 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 73 662 2.525e-14 1.566e-12
76 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 36 197 5.584e-14 3.418e-12
77 REGULATION OF NEURON DEATH 41 252 6.005e-14 3.629e-12
78 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 56 437 6.359e-14 3.793e-12
79 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 94 1008 1.306e-13 7.692e-12
80 RESPONSE TO ORGANIC CYCLIC COMPOUND 88 917 1.709e-13 9.943e-12
81 CELL DEATH 93 1001 2.224e-13 1.278e-11
82 GLIOGENESIS 33 175 2.508e-13 1.423e-11
83 POSITIVE REGULATION OF MAP KINASE ACTIVITY 36 207 2.661e-13 1.492e-11
84 REGULATION OF CYTOKINE PRODUCTION 64 563 2.735e-13 1.515e-11
85 AGING 41 264 2.966e-13 1.624e-11
86 RESPONSE TO OXIDATIVE STRESS 48 352 4.132e-13 2.236e-11
87 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 67 616 5.918e-13 3.165e-11
88 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 83 867 1.01e-12 5.338e-11
89 IMMUNE SYSTEM DEVELOPMENT 64 582 1.228e-12 6.42e-11
90 CELL PROLIFERATION 70 672 1.391e-12 7.191e-11
91 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 28 135 1.441e-12 7.367e-11
92 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 51 404 1.546e-12 7.819e-11
93 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 71 689 1.599e-12 7.999e-11
94 REGULATION OF JNK CASCADE 30 159 3.023e-12 1.496e-10
95 RESPONSE TO LIPID 83 888 3.571e-12 1.749e-10
96 REGULATION OF IMMUNE RESPONSE 81 858 3.987e-12 1.931e-10
97 VASCULATURE DEVELOPMENT 55 469 4.026e-12 1.931e-10
98 RESPONSE TO HORMONE 83 893 4.787e-12 2.273e-10
99 REGULATION OF CELLULAR COMPONENT BIOGENESIS 75 767 4.875e-12 2.291e-10
100 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 47 365 5.839e-12 2.717e-10
101 REGULATION OF CELLULAR COMPONENT MOVEMENT 75 771 6.278e-12 2.892e-10
102 CARDIOVASCULAR SYSTEM DEVELOPMENT 76 788 6.843e-12 3.091e-10
103 CIRCULATORY SYSTEM DEVELOPMENT 76 788 6.843e-12 3.091e-10
104 CELLULAR RESPONSE TO CYTOKINE STIMULUS 64 606 7.34e-12 3.284e-10
105 CELLULAR RESPONSE TO NITROGEN COMPOUND 57 505 7.721e-12 3.421e-10
106 ACTIVATION OF PROTEIN KINASE ACTIVITY 40 279 7.86e-12 3.45e-10
107 RESPONSE TO EXTRACELLULAR STIMULUS 52 441 1.285e-11 5.589e-10
108 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 72 740 1.69e-11 7.279e-10
109 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 118 1517 1.955e-11 8.346e-10
110 NEGATIVE REGULATION OF NEURON DEATH 30 171 2.074e-11 8.772e-10
111 REGULATION OF CATABOLIC PROCESS 71 731 2.554e-11 1.07e-09
112 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 39 278 2.826e-11 1.174e-09
113 REGULATION OF CELLULAR PROTEIN LOCALIZATION 59 552 3.09e-11 1.272e-09
114 EMBRYO DEVELOPMENT 81 894 3.189e-11 1.295e-09
115 REGULATION OF ORGANELLE ORGANIZATION 98 1178 3.2e-11 1.295e-09
116 CELL ACTIVATION 60 568 3.386e-11 1.358e-09
117 PROTEIN LOCALIZATION 133 1805 3.653e-11 1.447e-09
118 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 32 197 3.669e-11 1.447e-09
119 NEGATIVE REGULATION OF CYTOKINE PRODUCTION 33 211 5.165e-11 2.02e-09
120 RESPONSE TO ALCOHOL 45 362 5.492e-11 2.13e-09
121 REGULATION OF WNT SIGNALING PATHWAY 41 310 5.776e-11 2.221e-09
122 REGULATION OF NEURON APOPTOTIC PROCESS 31 192 8.695e-11 3.316e-09
123 GLAND DEVELOPMENT 47 395 9.31e-11 3.522e-09
124 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 74 801 9.899e-11 3.715e-09
125 REGULATION OF MYELOID CELL DIFFERENTIATION 30 183 1.19e-10 4.43e-09
126 ESTABLISHMENT OF PROTEIN LOCALIZATION 110 1423 1.514e-10 5.592e-09
127 REGULATION OF INTRACELLULAR TRANSPORT 62 621 1.634e-10 5.987e-09
128 POSITIVE REGULATION OF CELL PROLIFERATION 74 814 2.068e-10 7.519e-09
129 VESICLE MEDIATED TRANSPORT 99 1239 2.383e-10 8.594e-09
130 TUBE DEVELOPMENT 57 552 2.567e-10 9.188e-09
131 REGULATION OF HEMOPOIESIS 40 314 3.122e-10 1.109e-08
132 GLIAL CELL DIFFERENTIATION 25 136 3.501e-10 1.234e-08
133 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 24 126 3.682e-10 1.288e-08
134 REGULATION OF CELL PROJECTION ORGANIZATION 57 558 3.877e-10 1.346e-08
135 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 33 228 4.178e-10 1.44e-08
136 MAMMARY GLAND DEVELOPMENT 23 117 4.443e-10 1.52e-08
137 RESPONSE TO METAL ION 41 333 5.329e-10 1.81e-08
138 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 40 321 6.061e-10 2.043e-08
139 REGULATION OF BINDING 37 283 6.972e-10 2.334e-08
140 BLOOD VESSEL MORPHOGENESIS 43 364 7.439e-10 2.472e-08
141 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 46 406 7.495e-10 2.474e-08
142 RESPONSE TO OXYGEN LEVELS 39 311 8.268e-10 2.69e-08
143 PEPTIDYL TYROSINE MODIFICATION 29 186 8.217e-10 2.69e-08
144 EPITHELIAL CELL DIFFERENTIATION 52 495 8.769e-10 2.833e-08
145 NEURON DIFFERENTIATION 76 874 8.904e-10 2.857e-08
146 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 44 381 9.675e-10 3.083e-08
147 POSITIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 24 132 9.941e-10 3.146e-08
148 NEGATIVE REGULATION OF GENE EXPRESSION 111 1493 1.2e-09 3.772e-08
149 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 38 303 1.36e-09 4.246e-08
150 RESPONSE TO REACTIVE OXYGEN SPECIES 29 191 1.551e-09 4.81e-08
151 RESPONSE TO DRUG 47 431 1.726e-09 5.283e-08
152 NEGATIVE REGULATION OF CELL PROLIFERATION 61 643 1.722e-09 5.283e-08
153 REGULATION OF CELL ADHESION 60 629 1.91e-09 5.81e-08
154 RESPONSE TO PEPTIDE 45 404 1.976e-09 5.971e-08
155 REGULATION OF TRANSPORT 127 1804 1.992e-09 5.98e-08
156 ACTIVATION OF MAPK ACTIVITY 24 137 2.172e-09 6.478e-08
157 REGULATION OF PROTEOLYSIS 65 711 2.213e-09 6.557e-08
158 EMBRYONIC ORGAN DEVELOPMENT 45 406 2.31e-09 6.802e-08
159 REGULATION OF CELLULAR LOCALIZATION 98 1277 2.524e-09 7.388e-08
160 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 41 352 2.819e-09 8.198e-08
161 REGULATION OF VASCULATURE DEVELOPMENT 32 233 2.918e-09 8.432e-08
162 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 63 684 2.956e-09 8.491e-08
163 REGULATION OF CELL CYCLE 79 949 2.999e-09 8.562e-08
164 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 51 498 3.061e-09 8.685e-08
165 CELLULAR RESPONSE TO PEPTIDE 35 274 3.748e-09 1.057e-07
166 CELLULAR MACROMOLECULE LOCALIZATION 95 1234 3.884e-09 1.089e-07
167 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 32 236 4.019e-09 1.12e-07
168 ESTABLISHMENT OF LOCALIZATION IN CELL 119 1676 4.298e-09 1.19e-07
169 MYELOID CELL DIFFERENTIATION 28 189 5.198e-09 1.431e-07
170 CELLULAR RESPONSE TO HORMONE STIMULUS 54 552 5.275e-09 1.444e-07
171 RESPONSE TO ACID CHEMICAL 38 319 5.783e-09 1.573e-07
172 LEUKOCYTE DIFFERENTIATION 36 292 5.848e-09 1.582e-07
173 REGULATION OF GROWTH 59 633 6.188e-09 1.664e-07
174 ANGIOGENESIS 36 293 6.408e-09 1.714e-07
175 REGULATION OF APOPTOTIC SIGNALING PATHWAY 41 363 6.946e-09 1.847e-07
176 REGULATION OF PROTEIN LOCALIZATION 78 950 6.996e-09 1.85e-07
177 REGULATION OF CYTOPLASMIC TRANSPORT 49 481 7.456e-09 1.96e-07
178 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 38 323 8.161e-09 2.133e-07
179 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 51 513 8.314e-09 2.161e-07
180 POSITIVE REGULATION OF NEURON DEATH 16 67 1.072e-08 2.77e-07
181 GLIAL CELL DEVELOPMENT 17 76 1.083e-08 2.783e-07
182 PEPTIDYL AMINO ACID MODIFICATION 71 841 1.125e-08 2.86e-07
183 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 76 926 1.125e-08 2.86e-07
184 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 25 162 1.482e-08 3.747e-07
185 REGULATION OF HOMEOSTATIC PROCESS 46 447 1.585e-08 3.987e-07
186 CELLULAR RESPONSE TO EXTERNAL STIMULUS 33 264 1.791e-08 4.48e-07
187 POSITIVE REGULATION OF LOCOMOTION 44 420 1.924e-08 4.787e-07
188 RESPONSE TO HYDROGEN PEROXIDE 20 109 2.088e-08 5.167e-07
189 RESPONSE TO BACTERIUM 51 528 2.151e-08 5.296e-07
190 REGULATION OF PROTEIN TARGETING 36 307 2.196e-08 5.379e-07
191 CYTOKINE MEDIATED SIGNALING PATHWAY 46 452 2.229e-08 5.43e-07
192 TUBE MORPHOGENESIS 37 323 2.61e-08 6.326e-07
193 RESPONSE TO NUTRIENT 27 191 2.696e-08 6.499e-07
194 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 23 144 2.878e-08 6.867e-07
195 REGULATION OF TYPE I INTERFERON PRODUCTION 20 111 2.878e-08 6.867e-07
196 PROTEIN AUTOPHOSPHORYLATION 27 192 3.015e-08 7.158e-07
197 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 29 218 3.296e-08 7.784e-07
198 JNK CASCADE 17 82 3.631e-08 8.533e-07
199 INTRACELLULAR PROTEIN TRANSPORT 66 781 3.65e-08 8.534e-07
200 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 30 232 3.678e-08 8.556e-07
201 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 19 103 4.292e-08 9.936e-07
202 REGULATION OF VESICLE MEDIATED TRANSPORT 46 462 4.325e-08 9.963e-07
203 RESPONSE TO ETHANOL 22 136 4.537e-08 1.04e-06
204 NEGATIVE REGULATION OF CELL CYCLE 44 433 4.723e-08 1.077e-06
205 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 26 184 4.906e-08 1.113e-06
206 APOPTOTIC SIGNALING PATHWAY 34 289 4.982e-08 1.125e-06
207 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 46 465 5.253e-08 1.181e-06
208 ORGAN MORPHOGENESIS 69 841 5.611e-08 1.255e-06
209 ACTIVATION OF MAPKKK ACTIVITY 7 11 5.995e-08 1.335e-06
210 REGULATION OF CELL ACTIVATION 47 484 6.599e-08 1.455e-06
211 REGULATION OF ERK1 AND ERK2 CASCADE 30 238 6.569e-08 1.455e-06
212 POSITIVE REGULATION OF IMMUNE RESPONSE 52 563 6.757e-08 1.483e-06
213 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 26 188 7.637e-08 1.661e-06
214 WNT SIGNALING PATHWAY 38 351 7.638e-08 1.661e-06
215 CELLULAR COMPONENT MORPHOGENESIS 72 900 7.78e-08 1.684e-06
216 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 23 152 8.074e-08 1.739e-06
217 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 20 118 8.332e-08 1.787e-06
218 RESPONSE TO TOXIC SUBSTANCE 30 241 8.709e-08 1.859e-06
219 RESPONSE TO RADIATION 42 413 9.349e-08 1.986e-06
220 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 75 957 9.475e-08 2.004e-06
221 REGULATION OF EPITHELIAL CELL MIGRATION 24 166 1.029e-07 2.166e-06
222 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 52 573 1.186e-07 2.486e-06
223 OLIGODENDROCYTE DIFFERENTIATION 14 60 1.217e-07 2.539e-06
224 NEGATIVE REGULATION OF MAPK CASCADE 22 145 1.467e-07 3.033e-06
225 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 28 220 1.463e-07 3.033e-06
226 RESPONSE TO KETONE 25 182 1.548e-07 3.187e-06
227 RESPONSE TO ESTRADIOL 22 146 1.66e-07 3.394e-06
228 RESPONSE TO WOUNDING 51 563 1.663e-07 3.394e-06
229 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 21 135 1.819e-07 3.697e-06
230 REGULATION OF NEURON PROJECTION DEVELOPMENT 41 408 1.836e-07 3.714e-06
231 REGULATION OF JUN KINASE ACTIVITY 16 81 1.857e-07 3.741e-06
232 TISSUE MORPHOGENESIS 49 533 1.871e-07 3.752e-06
233 REGULATION OF CELL DEVELOPMENT 67 836 2.107e-07 4.207e-06
234 POSITIVE REGULATION OF JUN KINASE ACTIVITY 14 63 2.335e-07 4.643e-06
235 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 50 554 2.463e-07 4.877e-06
236 NEURON DEVELOPMENT 58 687 2.608e-07 5.139e-06
237 REGULATION OF OXIDATIVE STRESS INDUCED CELL DEATH 12 46 2.618e-07 5.139e-06
238 MULTI ORGANISM METABOLIC PROCESS 21 138 2.664e-07 5.208e-06
239 LEUKOCYTE ACTIVATION 41 414 2.716e-07 5.289e-06
240 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 91 1275 2.823e-07 5.473e-06
241 MORPHOGENESIS OF AN EPITHELIUM 40 400 2.945e-07 5.686e-06
242 POSITIVE REGULATION OF CYTOKINE PRODUCTION 38 370 2.977e-07 5.725e-06
243 NEGATIVE REGULATION OF CELL DIFFERENTIATION 53 609 3.389e-07 6.463e-06
244 POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS 12 47 3.383e-07 6.463e-06
245 NON CANONICAL WNT SIGNALING PATHWAY 21 140 3.413e-07 6.482e-06
246 PEPTIDYL TYROSINE AUTOPHOSPHORYLATION 11 39 3.48e-07 6.582e-06
247 REGULATION OF FAT CELL DIFFERENTIATION 18 106 3.567e-07 6.719e-06
248 NEURON PROJECTION DEVELOPMENT 49 545 3.644e-07 6.837e-06
249 REGULATION OF ACTIN CYTOSKELETON REORGANIZATION 10 32 4.122e-07 7.702e-06
250 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 37 360 4.183e-07 7.785e-06
251 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 61 750 4.583e-07 8.496e-06
252 NEGATIVE REGULATION OF TYPE I INTERFERON PRODUCTION 11 40 4.62e-07 8.531e-06
253 REGULATION OF CELL CYCLE ARREST 18 108 4.759e-07 8.753e-06
254 NEGATIVE REGULATION OF BINDING 20 131 4.84e-07 8.866e-06
255 CELLULAR RESPONSE TO OXYGEN LEVELS 21 143 4.904e-07 8.948e-06
256 REGULATION OF PROTEIN CATABOLIC PROCESS 39 393 5.035e-07 9.151e-06
257 POSITIVE REGULATION OF CELL DEVELOPMENT 44 472 5.422e-07 9.816e-06
258 RESPONSE TO VITAMIN 17 98 5.489e-07 9.9e-06
259 REGULATION OF BODY FLUID LEVELS 46 506 6.104e-07 1.097e-05
260 REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 21 145 6.207e-07 1.111e-05
261 RESPONSE TO PURINE CONTAINING COMPOUND 22 158 6.726e-07 1.199e-05
262 REGULATION OF DEFENSE RESPONSE 61 759 6.847e-07 1.216e-05
263 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 23 171 7.04e-07 1.245e-05
264 POSITIVE REGULATION OF TRANSPORT 71 936 7.195e-07 1.268e-05
265 CELL PROJECTION ORGANIZATION 69 902 7.679e-07 1.348e-05
266 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 37 372 9.324e-07 1.631e-05
267 ACTIVATION OF JUN KINASE ACTIVITY 10 35 1.047e-06 1.82e-05
268 REGULATION OF ORGAN MORPHOGENESIS 28 242 1.048e-06 1.82e-05
269 POSITIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 12 52 1.103e-06 1.908e-05
270 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 41 437 1.119e-06 1.929e-05
271 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 27 229 1.126e-06 1.933e-05
272 REGULATION OF PROTEIN COMPLEX ASSEMBLY 37 375 1.132e-06 1.936e-05
273 POSITIVE REGULATION OF HEMOPOIESIS 22 163 1.152e-06 1.964e-05
274 REGULATION OF CELL GROWTH 38 391 1.177e-06 1.999e-05
275 POSITIVE REGULATION OF CELL ADHESION 37 376 1.206e-06 2.041e-05
276 LOCOMOTION 80 1114 1.233e-06 2.079e-05
277 RESPONSE TO ORGANOPHOSPHORUS 20 139 1.27e-06 2.133e-05
278 REPRODUCTIVE SYSTEM DEVELOPMENT 39 408 1.289e-06 2.158e-05
279 INTRINSIC APOPTOTIC SIGNALING PATHWAY 21 152 1.366e-06 2.279e-05
280 MAMMARY GLAND EPITHELIUM DEVELOPMENT 12 53 1.373e-06 2.281e-05
281 REGULATION OF ERYTHROCYTE DIFFERENTIATION 10 36 1.396e-06 2.307e-05
282 POSITIVE REGULATION OF PROTEOLYSIS 36 363 1.398e-06 2.307e-05
283 RESPONSE TO ESTROGEN 26 218 1.424e-06 2.342e-05
284 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 58 724 1.435e-06 2.343e-05
285 REGULATION OF OSSIFICATION 23 178 1.434e-06 2.343e-05
286 EMBRYONIC MORPHOGENESIS 47 539 1.493e-06 2.43e-05
287 NEGATIVE REGULATION OF MAP KINASE ACTIVITY 14 73 1.569e-06 2.53e-05
288 VIRAL LIFE CYCLE 31 290 1.572e-06 2.53e-05
289 ACTIVATION OF IMMUNE RESPONSE 40 427 1.571e-06 2.53e-05
290 RESPONSE TO BIOTIC STIMULUS 67 886 1.667e-06 2.675e-05
291 CELL CYCLE ARREST 21 154 1.695e-06 2.711e-05
292 NEGATIVE REGULATION OF MYELOID CELL DIFFERENTIATION 15 84 1.731e-06 2.748e-05
293 POSITIVE REGULATION OF OSSIFICATION 15 84 1.731e-06 2.748e-05
294 REGULATION OF PROTEIN ACETYLATION 13 64 1.871e-06 2.961e-05
295 CENTRAL NERVOUS SYSTEM DEVELOPMENT 66 872 1.939e-06 3.059e-05
296 RESPONSE TO RETINOIC ACID 17 107 1.963e-06 3.086e-05
297 MYELOID LEUKOCYTE DIFFERENTIATION 16 96 2.044e-06 3.202e-05
298 LYMPHOCYTE DIFFERENTIATION 25 209 2.141e-06 3.343e-05
299 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 36 370 2.183e-06 3.397e-05
300 REGULATION OF RESPONSE TO OXIDATIVE STRESS 13 65 2.251e-06 3.491e-05
301 NEURON PROJECTION MORPHOGENESIS 38 402 2.302e-06 3.559e-05
302 REGULATION OF PROTEIN IMPORT 23 183 2.324e-06 3.581e-05
303 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 15 86 2.356e-06 3.618e-05
304 POSITIVE REGULATION OF PROTEIN COMPLEX ASSEMBLY 24 197 2.463e-06 3.769e-05
305 REGULATION OF INNATE IMMUNE RESPONSE 35 357 2.538e-06 3.873e-05
306 CELLULAR RESPONSE TO OXIDATIVE STRESS 23 184 2.554e-06 3.883e-05
307 LYMPHOCYTE ACTIVATION 34 342 2.587e-06 3.922e-05
308 REGULATION OF ACTIN FILAMENT BASED PROCESS 32 312 2.621e-06 3.96e-05
309 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 50 602 2.818e-06 4.244e-05
310 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 25 213 3.025e-06 4.541e-05
311 EPITHELIAL CELL DEVELOPMENT 23 186 3.076e-06 4.603e-05
312 REGULATION OF EPITHELIAL CELL PROLIFERATION 30 285 3.164e-06 4.706e-05
313 REGULATION OF NEURON DIFFERENTIATION 47 554 3.17e-06 4.706e-05
314 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 15 88 3.176e-06 4.706e-05
315 REGULATION OF PEPTIDASE ACTIVITY 37 392 3.231e-06 4.772e-05
316 PYRIMIDINE NUCLEOTIDE METABOLIC PROCESS 11 48 3.33e-06 4.904e-05
317 PEPTIDYL SERINE MODIFICATION 20 148 3.432e-06 5.037e-05
318 CELLULAR RESPONSE TO LIPID 41 457 3.462e-06 5.065e-05
319 REGULATION OF OSTEOBLAST DIFFERENTIATION 17 112 3.742e-06 5.458e-05
320 ENDOCYTOSIS 44 509 4.037e-06 5.871e-05
321 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 29 274 4.128e-06 5.98e-05
322 SENSORY ORGAN DEVELOPMENT 43 493 4.139e-06 5.98e-05
323 PYRIMIDINE CONTAINING COMPOUND METABOLIC PROCESS 14 79 4.191e-06 6.037e-05
324 OVULATION CYCLE 17 113 4.236e-06 6.084e-05
325 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 23 190 4.424e-06 6.334e-05
326 REGULATION OF LEUKOCYTE DIFFERENTIATION 26 232 4.562e-06 6.511e-05
327 REGULATION OF ENDOTHELIAL CELL MIGRATION 17 114 4.789e-06 6.814e-05
328 RESPONSE TO PROGESTERONE 11 50 5.103e-06 7.239e-05
329 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 44 514 5.189e-06 7.339e-05
330 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 56 720 5.326e-06 7.51e-05
331 CELLULAR RESPONSE TO ABIOTIC STIMULUS 28 263 5.381e-06 7.565e-05
332 RESPONSE TO CALCIUM ION 17 115 5.405e-06 7.575e-05
333 REGULATION OF AUTOPHAGY 27 249 5.605e-06 7.831e-05
334 ACTIN FILAMENT BASED PROCESS 40 450 5.684e-06 7.918e-05
335 ESTABLISHMENT OF PROTEIN LOCALIZATION TO MEMBRANE 28 264 5.787e-06 8.038e-05
336 CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES 16 104 6.006e-06 8.317e-05
337 MORPHOGENESIS OF A BRANCHING STRUCTURE 21 167 6.276e-06 8.665e-05
338 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 29 280 6.318e-06 8.697e-05
339 REGULATION OF DNA BINDING 15 93 6.444e-06 8.819e-05
340 REGULATION OF MITOPHAGY 10 42 6.443e-06 8.819e-05
341 POSITIVE REGULATION OF CELL ACTIVATION 31 311 6.723e-06 9.147e-05
342 IMMUNE EFFECTOR PROCESS 42 486 6.717e-06 9.147e-05
343 HOMEOSTATIC PROCESS 89 1337 6.811e-06 9.24e-05
344 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 23 195 6.857e-06 9.275e-05
345 PROTEIN KINASE B SIGNALING 9 34 7.335e-06 9.893e-05
346 RESPONSE TO MECHANICAL STIMULUS 24 210 7.523e-06 0.0001012
347 CELLULAR RESPONSE TO INORGANIC SUBSTANCE 20 156 7.73e-06 0.0001037
348 PROTEIN LOCALIZATION TO MEMBRANE 35 376 8.038e-06 0.0001075
349 RESPIRATORY SYSTEM DEVELOPMENT 23 197 8.132e-06 0.0001084
350 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 18 131 8.266e-06 0.0001099
351 NEGATIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 15 95 8.428e-06 0.0001114
352 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 15 95 8.428e-06 0.0001114
353 REGULATION OF RESPONSE TO CYTOKINE STIMULUS 19 144 8.523e-06 0.0001123
354 POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 17 119 8.646e-06 0.0001136
355 REGULATION OF RESPONSE TO EXTRACELLULAR STIMULUS 21 171 9.108e-06 0.000119
356 REGULATION OF RESPONSE TO NUTRIENT LEVELS 21 171 9.108e-06 0.000119
357 IMMUNE RESPONSE 76 1100 9.307e-06 0.0001213
358 NEGATIVE REGULATION OF RESPONSE TO OXIDATIVE STRESS 9 35 9.512e-06 0.0001233
359 NEGATIVE REGULATION OF CELLULAR RESPONSE TO OXIDATIVE STRESS 9 35 9.512e-06 0.0001233
360 REGULATION OF ENDOCYTOSIS 23 199 9.618e-06 0.0001243
361 SINGLE ORGANISM CELLULAR LOCALIZATION 65 898 9.995e-06 0.0001288
362 MYELOID CELL DEVELOPMENT 10 44 1.008e-05 0.0001295
363 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 13 74 1.015e-05 0.0001302
364 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 27 258 1.081e-05 0.0001382
365 REGULATION OF PROTEIN KINASE B SIGNALING 17 121 1.084e-05 0.0001382
366 RESPONSE TO STEROID HORMONE 42 497 1.159e-05 0.0001473
367 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 24 216 1.215e-05 0.0001541
368 DEOXYRIBONUCLEOTIDE METABOLIC PROCESS 9 36 1.222e-05 0.0001545
369 NEGATIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 18 135 1.263e-05 0.0001592
370 POSITIVE REGULATION OF NEURON DIFFERENTIATION 30 306 1.304e-05 0.0001639
371 REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 12 65 1.31e-05 0.0001643
372 DEOXYRIBOSE PHOSPHATE CATABOLIC PROCESS 7 21 1.465e-05 0.0001833
373 DEFENSE RESPONSE 82 1231 1.566e-05 0.0001954
374 CYTOSKELETON ORGANIZATION 61 838 1.591e-05 0.0001979
375 REGULATION OF LEUKOCYTE PROLIFERATION 23 206 1.696e-05 0.0002099
376 FC RECEPTOR SIGNALING PATHWAY 23 206 1.696e-05 0.0002099
377 REGULATION OF OXIDATIVE STRESS INDUCED INTRINSIC APOPTOTIC SIGNALING PATHWAY 8 29 1.708e-05 0.0002108
378 RESPONSE TO LIGHT STIMULUS 28 280 1.746e-05 0.000215
379 IN UTERO EMBRYONIC DEVELOPMENT 30 311 1.783e-05 0.0002189
380 REGULATION OF TUMOR NECROSIS FACTOR SUPERFAMILY CYTOKINE PRODUCTION 15 101 1.802e-05 0.0002207
381 CELL AGING 12 67 1.808e-05 0.0002208
382 REGULATION OF OXIDOREDUCTASE ACTIVITY 14 90 1.993e-05 0.0002415
383 ENDOTHELIUM DEVELOPMENT 14 90 1.993e-05 0.0002415
384 MUSCLE SYSTEM PROCESS 28 282 1.99e-05 0.0002415
385 POSITIVE REGULATION OF BINDING 17 127 2.073e-05 0.0002505
386 RHYTHMIC PROCESS 29 298 2.078e-05 0.0002505
387 ERBB SIGNALING PATHWAY 13 79 2.114e-05 0.0002542
388 REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 21 181 2.187e-05 0.0002623
389 REGULATED EXOCYTOSIS 24 224 2.232e-05 0.000267
390 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 15 103 2.289e-05 0.0002731
391 POSITIVE REGULATION OF CATABOLIC PROCESS 35 395 2.308e-05 0.0002746
392 REGULATION OF PROTEIN BINDING 20 168 2.341e-05 0.0002779
393 CELLULAR RESPONSE TO NUTRIENT 9 39 2.459e-05 0.0002911
394 REGULATION OF CELL CELL ADHESION 34 380 2.465e-05 0.0002911
395 CELL JUNCTION ASSEMBLY 17 129 2.548e-05 0.0003002
396 RESPONSE TO CAMP 15 104 2.574e-05 0.0003024
397 DEVELOPMENTAL GROWTH 31 333 2.608e-05 0.0003056
398 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 11 59 2.717e-05 0.0003177
399 CIRCULATORY SYSTEM PROCESS 33 366 2.77e-05 0.0003206
400 NEGATIVE REGULATION OF CYTOPLASMIC TRANSPORT 16 117 2.754e-05 0.0003206
401 REGULATION OF NITRIC OXIDE SYNTHASE ACTIVITY 10 49 2.764e-05 0.0003206
402 CELLULAR RESPONSE TO CALCIUM ION 10 49 2.764e-05 0.0003206
403 POSITIVE REGULATION OF MYELOID CELL DIFFERENTIATION 13 81 2.785e-05 0.0003216
404 RAS PROTEIN SIGNAL TRANSDUCTION 18 143 2.794e-05 0.0003218
405 POSITIVE REGULATION OF TYPE I INTERFERON PRODUCTION 12 70 2.86e-05 0.000327
406 POSITIVE REGULATION OF ACTIN CYTOSKELETON REORGANIZATION 6 16 2.848e-05 0.000327
407 MUSCLE STRUCTURE DEVELOPMENT 37 432 2.854e-05 0.000327
408 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 23 213 2.903e-05 0.0003311
409 LIPOPOLYSACCHARIDE MEDIATED SIGNALING PATHWAY 8 31 2.916e-05 0.0003317
410 POSITIVE REGULATION OF DNA METABOLIC PROCESS 21 185 3.041e-05 0.0003435
411 CELL JUNCTION ORGANIZATION 21 185 3.041e-05 0.0003435
412 REGULATION OF CELL MORPHOGENESIS 44 552 3.032e-05 0.0003435
413 FORELIMB MORPHOGENESIS 9 40 3.056e-05 0.0003443
414 REGULATION OF MONOOXYGENASE ACTIVITY 11 60 3.204e-05 0.0003592
415 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 11 60 3.204e-05 0.0003592
416 NEGATIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 12 71 3.313e-05 0.0003706
417 REPRODUCTION 84 1297 3.394e-05 0.0003787
418 T CELL RECEPTOR SIGNALING PATHWAY 18 146 3.701e-05 0.000412
419 PYRIMIDINE NUCLEOSIDE BIOSYNTHETIC PROCESS 8 32 3.747e-05 0.0004151
420 PYRIMIDINE CONTAINING COMPOUND CATABOLIC PROCESS 8 32 3.747e-05 0.0004151
421 CELLULAR RESPONSE TO HYDROGEN PEROXIDE 11 61 3.763e-05 0.0004159
422 REGULATION OF DNA METABOLIC PROCESS 31 340 3.887e-05 0.0004286
423 ERYTHROCYTE DEVELOPMENT 7 24 3.909e-05 0.00043
424 REGULATION OF BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 10 51 3.986e-05 0.0004364
425 PYRIMIDINE NUCLEOSIDE METABOLIC PROCESS 10 51 3.986e-05 0.0004364
426 REGULATION OF METAL ION TRANSPORT 30 325 4.102e-05 0.000448
427 REGENERATION 19 161 4.197e-05 0.0004563
428 REGULATION OF MITOCHONDRION ORGANIZATION 23 218 4.191e-05 0.0004563
429 POSITIVE REGULATION OF CYTOSKELETON ORGANIZATION 20 175 4.233e-05 0.0004575
430 REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 24 233 4.248e-05 0.0004575
431 HOMEOSTASIS OF NUMBER OF CELLS 20 175 4.233e-05 0.0004575
432 RESPONSE TO TUMOR NECROSIS FACTOR 24 233 4.248e-05 0.0004575
433 REGULATION OF PROTEASOMAL UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 18 148 4.443e-05 0.0004763
434 RESPONSE TO TEMPERATURE STIMULUS 18 148 4.443e-05 0.0004763
435 POSITIVE REGULATION OF OXIDATIVE STRESS INDUCED CELL DEATH 5 11 4.612e-05 0.0004934
436 PYRIMIDINE CONTAINING COMPOUND BIOSYNTHETIC PROCESS 9 42 4.625e-05 0.0004936
437 NEGATIVE REGULATION OF ERK1 AND ERK2 CASCADE 10 52 4.753e-05 0.0005061
438 CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 8 33 4.767e-05 0.0005064
439 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 15 110 5.033e-05 0.0005335
440 RESPONSE TO OSMOTIC STRESS 11 63 5.139e-05 0.0005422
441 T CELL DIFFERENTIATION 16 123 5.134e-05 0.0005422
442 MYELOID LEUKOCYTE ACTIVATION 14 98 5.291e-05 0.000557
443 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 22 207 5.47e-05 0.0005745
444 INNATE IMMUNE RESPONSE 47 619 5.491e-05 0.0005754
445 REGULATION OF NITRIC OXIDE BIOSYNTHETIC PROCESS 10 53 5.643e-05 0.00059
446 NEGATIVE REGULATION OF HOMEOSTATIC PROCESS 16 124 5.671e-05 0.0005917
447 DEVELOPMENTAL MATURATION 21 193 5.695e-05 0.0005928
448 TAXIS 38 464 5.896e-05 0.0006124
449 OLIGODENDROCYTE DEVELOPMENT 8 34 6.008e-05 0.0006226
450 POSITIVE REGULATION OF CELL CYCLE 30 332 6.078e-05 0.0006285
451 PLACENTA DEVELOPMENT 17 138 6.099e-05 0.0006292
452 PYRIMIDINE DEOXYRIBONUCLEOTIDE METABOLIC PROCESS 6 18 6.146e-05 0.0006313
453 RESPONSE TO WATER 6 18 6.146e-05 0.0006313
454 MULTICELLULAR ORGANISM GROWTH 12 76 6.638e-05 0.0006803
455 OVULATION CYCLE PROCESS 13 88 6.816e-05 0.0006935
456 REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 9 44 6.826e-05 0.0006935
457 NEGATIVE REGULATION OF JAK STAT CASCADE 9 44 6.826e-05 0.0006935
458 NEGATIVE REGULATION OF STAT CASCADE 9 44 6.826e-05 0.0006935
459 RESPONSE TO UV 16 126 6.896e-05 0.0006991
460 REGULATION OF CYTOSKELETON ORGANIZATION 40 502 6.952e-05 0.0007032
461 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 32 368 7.31e-05 0.0007378
462 POSITIVE REGULATION OF PEPTIDASE ACTIVITY 18 154 7.518e-05 0.0007572
463 HEMIDESMOSOME ASSEMBLY 5 12 7.636e-05 0.0007657
464 PYRIMIDINE NUCLEOTIDE CATABOLIC PROCESS 5 12 7.636e-05 0.0007657
465 REGULATION OF MULTI ORGANISM PROCESS 38 470 7.734e-05 0.0007739
466 NEGATIVE REGULATION OF HEMOPOIESIS 16 128 8.347e-05 0.0008335
467 SKELETAL SYSTEM DEVELOPMENT 37 455 8.502e-05 0.0008471
468 PLATELET MORPHOGENESIS 6 19 8.668e-05 0.0008618
469 PLATELET ACTIVATION 17 142 8.751e-05 0.0008663
470 FC EPSILON RECEPTOR SIGNALING PATHWAY 17 142 8.751e-05 0.0008663
471 REGULATION OF LEUKOCYTE MEDIATED IMMUNITY 18 156 8.897e-05 0.000879
472 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 11 67 9.219e-05 0.0009088
473 POSITIVE REGULATION OF PROTEIN ACETYLATION 8 36 9.301e-05 0.0009131
474 REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING 8 36 9.301e-05 0.0009131
475 FEMALE SEX DIFFERENTIATION 15 116 9.354e-05 0.0009163
476 CELL PART MORPHOGENESIS 47 633 9.391e-05 0.0009179
477 NEGATIVE REGULATION OF INTRACELLULAR TRANSPORT 17 143 9.554e-05 0.000932
478 NEGATIVE REGULATION OF TRANSPORT 37 458 9.727e-05 0.0009469
479 NEGATIVE REGULATION OF PROTEIN BINDING 12 79 9.776e-05 0.0009496
480 CHEMICAL HOMEOSTASIS 60 874 9.92e-05 0.0009616
481 RECEPTOR MEDIATED ENDOCYTOSIS 23 231 0.0001024 0.0009905
482 POSITIVE REGULATION OF ERK1 AND ERK2 CASCADE 19 172 0.0001034 0.0009978
483 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 23 232 0.0001093 0.001053
484 SYSTEM PROCESS 106 1785 0.0001098 0.001055
485 CELL MATURATION 16 131 0.0001102 0.001058
486 ORGANIC CYCLIC COMPOUND CATABOLIC PROCESS 35 427 0.0001121 0.001074
487 TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 15 118 0.0001138 0.001087
488 REGULATION OF PEPTIDYL THREONINE PHOSPHORYLATION 8 37 0.0001144 0.001091
489 BIOLOGICAL ADHESION 68 1032 0.0001179 0.001122
490 MULTICELLULAR ORGANISM REPRODUCTION 54 768 0.0001205 0.001145
491 REGULATION OF FIBROBLAST PROLIFERATION 12 81 0.0001251 0.001186
492 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 14 106 0.0001261 0.001193
493 ACTIVATION OF INNATE IMMUNE RESPONSE 21 204 0.0001265 0.001194
494 RESPONSE TO INSULIN 21 205 0.0001355 0.001274
495 REGULATION OF SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 21 205 0.0001355 0.001274
496 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 9 48 0.0001391 0.0013
497 I KAPPAB KINASE NF KAPPAB SIGNALING 11 70 0.0001386 0.0013
498 RESPONSE TO AXON INJURY 9 48 0.0001391 0.0013
499 PLATELET DEGRANULATION 14 107 0.0001397 0.0013
500 MESENCHYME MORPHOGENESIS 8 38 0.0001396 0.0013
501 UROGENITAL SYSTEM DEVELOPMENT 27 299 0.000141 0.00131
502 POSITIVE REGULATION OF MONOOXYGENASE ACTIVITY 7 29 0.000147 0.001362
503 REGULATION OF MITOTIC CELL CYCLE 37 468 0.0001505 0.001392
504 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 15 121 0.0001514 0.001397
505 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 13 95 0.0001517 0.001397
506 REGULATION OF MYELOID LEUKOCYTE DIFFERENTIATION 14 108 0.0001545 0.00142
507 CELLULAR RESPONSE TO BIOTIC STIMULUS 18 163 0.0001564 0.001435
508 BODY FLUID SECRETION 11 71 0.0001579 0.001447
509 EMBRYONIC PLACENTA DEVELOPMENT 12 83 0.0001588 0.001452
510 MRNA TRANSCRIPTION 6 21 0.0001614 0.00147
511 NEGATIVE REGULATION OF OXIDATIVE STRESS INDUCED INTRINSIC APOPTOTIC SIGNALING PATHWAY 6 21 0.0001614 0.00147
512 ERBB2 SIGNALING PATHWAY 8 39 0.0001693 0.001533
513 MAINTENANCE OF LOCATION IN CELL 13 96 0.0001689 0.001533
514 NUCLEOTIDE EXCISION REPAIR DNA INCISION 8 39 0.0001693 0.001533
515 CELL MOTILITY 57 835 0.000171 0.001542
516 LOCALIZATION OF CELL 57 835 0.000171 0.001542
517 ENDOTHELIAL CELL DIFFERENTIATION 11 72 0.0001795 0.001608
518 POSITIVE REGULATION OF P38MAPK CASCADE 5 14 0.00018 0.001608
519 REGULATION OF PROTON TRANSPORT 5 14 0.00018 0.001608
520 REGULATION OF MONOCYTE DIFFERENTIATION 5 14 0.00018 0.001608
521 REGULATION OF PROTEIN KINASE C SIGNALING 5 14 0.00018 0.001608
522 CELLULAR RESPONSE TO VASCULAR ENDOTHELIAL GROWTH FACTOR STIMULUS 7 30 0.0001849 0.001648
523 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 29 337 0.0001872 0.001666
524 REGULATION OF TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 9 50 0.000193 0.001714
525 POSITIVE REGULATION OF CELL CYCLE ARREST 12 85 2e-04 0.001773
526 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 17 152 0.0002024 0.00179
527 MAMMARY GLAND MORPHOGENESIS 8 40 0.000204 0.001795
528 REGULATION OF PLASMA MEMBRANE ORGANIZATION 11 73 0.0002035 0.001795
529 CYTOPLASMIC SEQUESTERING OF PROTEIN 8 40 0.000204 0.001795
530 CELL FATE COMMITMENT 22 227 0.0002116 0.001855
531 REGULATION OF IMMUNE EFFECTOR PROCESS 34 424 0.0002114 0.001855
532 RESPONSE TO IMMOBILIZATION STRESS 6 22 0.0002142 0.001863
533 REGULATION OF B CELL DIFFERENTIATION 6 22 0.0002142 0.001863
534 POSITIVE REGULATION OF NITRIC OXIDE SYNTHASE ACTIVITY 6 22 0.0002142 0.001863
535 REGULATION OF CGMP BIOSYNTHETIC PROCESS 6 22 0.0002142 0.001863
536 SINGLE ORGANISM CELL ADHESION 36 459 0.0002148 0.001865
537 REGULATION OF HOMOTYPIC CELL CELL ADHESION 27 307 0.0002171 0.001881
538 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 17 153 0.000219 0.001894
539 NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 16 139 0.0002214 0.001911
540 REGULATION OF TISSUE REMODELING 10 62 0.000222 0.001913
541 POSITIVE REGULATION OF FAT CELL DIFFERENTIATION 9 51 0.0002258 0.001938
542 CELLULAR CARBOHYDRATE BIOSYNTHETIC PROCESS 9 51 0.0002258 0.001938
543 RESPONSE TO INTERLEUKIN 4 7 31 0.0002303 0.00197
544 NEGATIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 7 31 0.0002303 0.00197
545 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 17 154 0.0002369 0.002022
546 OSTEOBLAST DIFFERENTIATION 15 126 0.0002381 0.002029
547 GROWTH 33 410 0.0002434 0.002071
548 EYE DEVELOPMENT 28 326 0.0002476 0.002103
549 CELL CYCLE 81 1316 0.0002498 0.002117
550 EXOCYTOSIS 27 310 0.0002539 0.002148
551 REGULATION OF CYCLIC NUCLEOTIDE METABOLIC PROCESS 17 155 0.000256 0.002154
552 GASTRULATION 17 155 0.000256 0.002154
553 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 13 100 0.0002554 0.002154
554 ACTIVATION OF GTPASE ACTIVITY 11 75 0.0002598 0.002175
555 POSITIVE REGULATION OF RESPONSE TO OXIDATIVE STRESS 5 15 0.0002608 0.002175
556 GRANULOCYTE DIFFERENTIATION 5 15 0.0002608 0.002175
557 NEUROTROPHIN TRK RECEPTOR SIGNALING PATHWAY 5 15 0.0002608 0.002175
558 MRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 5 15 0.0002608 0.002175
559 NEGATIVE REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 9 52 0.0002631 0.00219
560 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 20 200 0.0002674 0.002222
561 POSITIVE REGULATION OF ERYTHROCYTE DIFFERENTIATION 6 23 0.0002796 0.002304
562 MYELOID CELL HOMEOSTASIS 12 88 0.0002786 0.002304
563 POSITIVE REGULATION OF HOMEOSTATIC PROCESS 21 216 0.0002798 0.002304
564 REGULATION OF RESPONSE TO WOUNDING 33 413 0.0002779 0.002304
565 ADRENAL GLAND DEVELOPMENT 6 23 0.0002796 0.002304
566 EMBRYONIC FORELIMB MORPHOGENESIS 7 32 0.0002843 0.002337
567 NEGATIVE REGULATION OF PROTEOLYSIS 28 329 0.0002877 0.002361
568 PROTEIN TARGETING TO MEMBRANE 17 157 0.0002982 0.002443
569 MUSCLE CONTRACTION 22 233 0.0003058 0.0025
570 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 15 129 0.0003084 0.002513
571 POSITIVE REGULATION OF DEFENSE RESPONSE 30 364 0.0003079 0.002513
572 CATABOLIC PROCESS 103 1773 0.0003098 0.00252
573 REGULATION OF CELL CYCLE PROCESS 41 558 0.0003208 0.002605
574 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 25 282 0.0003247 0.002632
575 NEGATIVE REGULATION OF CATABOLIC PROCESS 20 203 0.0003254 0.002633
576 SEX DIFFERENTIATION 24 266 0.0003278 0.002648
577 REGULATION OF ACTIN FILAMENT BUNDLE ASSEMBLY 11 77 0.0003287 0.002651
578 NUCLEOSIDE PHOSPHATE BIOSYNTHETIC PROCESS 19 188 0.0003296 0.002654
579 CELLULAR RESPONSE TO RETINOIC ACID 10 65 0.0003304 0.002655
580 REGULATION OF JAK STAT CASCADE 16 144 0.000332 0.002659
581 REGULATION OF STAT CASCADE 16 144 0.000332 0.002659
582 REGULATION OF INSULIN RECEPTOR SIGNALING PATHWAY 8 43 0.0003446 0.002755
583 OSSIFICATION 23 251 0.0003472 0.002771
584 RESPONSE TO VITAMIN D 7 33 0.000348 0.002773
585 REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 16 145 0.0003591 0.002856
586 MAMMARY GLAND EPITHELIAL CELL DIFFERENTIATION 5 16 0.0003665 0.002895
587 GUANOSINE CONTAINING COMPOUND BIOSYNTHETIC PROCESS 5 16 0.0003665 0.002895
588 APOPTOTIC PROCESS INVOLVED IN MORPHOGENESIS 5 16 0.0003665 0.002895
589 REGULATION OF ARF PROTEIN SIGNAL TRANSDUCTION 5 16 0.0003665 0.002895
590 MEMBRANE ORGANIZATION 59 899 0.0003674 0.002898
591 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ENDOPLASMIC RETICULUM 13 104 0.0003773 0.002966
592 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 13 104 0.0003773 0.002966
593 CELLULAR RESPONSE TO ACID CHEMICAL 18 175 0.0003783 0.002968
594 TRANSLATIONAL INITIATION 16 146 0.0003881 0.003035
595 CELLULAR RESPONSE TO INSULIN STIMULUS 16 146 0.0003881 0.003035
596 NUCLEAR TRANSCRIBED MRNA CATABOLIC PROCESS NONSENSE MEDIATED DECAY 14 118 0.0003934 0.003071
597 REGULATION OF INTERFERON BETA PRODUCTION 8 44 0.000406 0.003159
598 NEGATIVE REGULATION OF TUMOR NECROSIS FACTOR SUPERFAMILY CYTOKINE PRODUCTION 8 44 0.000406 0.003159
599 POSITIVE REGULATION OF GROWTH 22 238 0.0004104 0.003188
600 RESPONSE TO FLUID SHEAR STRESS 7 34 0.0004227 0.003278
601 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 10 67 0.0004247 0.003288
602 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 19 192 0.0004298 0.003322
603 POSITIVE REGULATION OF PEPTIDYL THREONINE PHOSPHORYLATION 6 25 0.0004569 0.003526
604 NEGATIVE REGULATION OF VASCULATURE DEVELOPMENT 11 80 0.0004604 0.003547
605 VASCULAR PROCESS IN CIRCULATORY SYSTEM 17 163 0.0004632 0.003563
606 LUNG MORPHOGENESIS 8 45 0.000476 0.003649
607 SPROUTING ANGIOGENESIS 8 45 0.000476 0.003649
608 REGULATION OF PHAGOCYTOSIS 10 68 0.0004797 0.003671
609 ORGANONITROGEN COMPOUND METABOLIC PROCESS 103 1796 0.0004885 0.00373
610 CONNECTIVE TISSUE DEVELOPMENT 19 194 0.000489 0.00373
611 BEHAVIOR 38 516 0.0005018 0.003822
612 NEGATIVE REGULATION OF INTERLEUKIN 6 PRODUCTION 7 35 0.0005096 0.003862
613 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 14 121 0.000509 0.003862
614 CLATHRIN MEDIATED ENDOCYTOSIS 7 35 0.0005096 0.003862
615 POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING 11 81 0.0005131 0.003882
616 REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 12 94 0.0005163 0.0039
617 REGULATION OF NUCLEOTIDE METABOLIC PROCESS 20 211 0.0005366 0.004047
618 NUCLEOSIDE PHOSPHATE CATABOLIC PROCESS 10 69 0.0005404 0.004069
619 POSITIVE REGULATION OF CELL CELL ADHESION 22 243 0.0005451 0.004098
620 CYCLIC NUCLEOTIDE MEDIATED SIGNALING 8 46 0.0005555 0.004162
621 POSITIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 19 196 0.0005553 0.004162
622 REGULATION OF ION TRANSPORT 42 592 0.0005594 0.004185
623 ORGANONITROGEN COMPOUND CATABOLIC PROCESS 28 343 0.0005604 0.004186
624 DEVELOPMENTAL PROGRAMMED CELL DEATH 6 26 0.0005732 0.004227
625 POLYOL METABOLIC PROCESS 12 95 0.000569 0.004227
626 CANONICAL WNT SIGNALING PATHWAY 12 95 0.000569 0.004227
627 REGULATION OF LIPID TRANSPORT 12 95 0.000569 0.004227
628 SCHWANN CELL DEVELOPMENT 6 26 0.0005732 0.004227
629 REGULATION OF P38MAPK CASCADE 6 26 0.0005732 0.004227
630 CELLULAR RESPONSE TO VITAMIN 6 26 0.0005732 0.004227
631 INACTIVATION OF MAPK ACTIVITY 6 26 0.0005732 0.004227
632 MUSCLE ORGAN DEVELOPMENT 24 277 0.0005893 0.004339
633 POSITIVE REGULATION OF CYCLIC NUCLEOTIDE METABOLIC PROCESS 13 109 0.0005964 0.004384
634 PROTEIN LOCALIZATION TO ENDOPLASMIC RETICULUM 14 123 0.0006011 0.004405
635 ENDOCRINE SYSTEM DEVELOPMENT 14 123 0.0006011 0.004405
636 NEGATIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 7 36 0.0006101 0.004464
637 NEGATIVE REGULATION OF HYDROLASE ACTIVITY 31 397 0.0006186 0.004518
638 MICROTUBULE BASED PROCESS 38 522 0.0006246 0.004555
639 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 12 96 0.0006261 0.004559
640 ORGAN REGENERATION 11 83 0.0006337 0.004607
641 MAINTENANCE OF LOCATION 15 138 0.000636 0.004617
642 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 22 246 0.0006432 0.004662
643 PIGMENT BIOSYNTHETIC PROCESS 8 47 0.0006454 0.00467
644 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 25 296 0.0006651 0.004805
645 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 23 263 0.0006684 0.004814
646 NEGATIVE REGULATION OF LOCOMOTION 23 263 0.0006684 0.004814
647 LABYRINTHINE LAYER BLOOD VESSEL DEVELOPMENT 5 18 0.0006707 0.004816
648 OVULATION 5 18 0.0006707 0.004816
649 WOUND HEALING 35 470 0.0006754 0.004843
650 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 10 71 0.0006811 0.004875
651 CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 15 139 0.0006862 0.00489
652 PURINE CONTAINING COMPOUND BIOSYNTHETIC PROCESS 15 139 0.0006862 0.00489
653 MITOTIC CELL CYCLE CHECKPOINT 15 139 0.0006862 0.00489
654 GLAND MORPHOGENESIS 12 97 0.000688 0.004895
655 REGULATION OF BLOOD PRESSURE 17 169 0.0007015 0.004984
656 KIDNEY EPITHELIUM DEVELOPMENT 14 125 0.0007071 0.005015
657 POSITIVE REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 13 111 0.00071 0.005028
658 NEGATIVE REGULATION OF FIBROBLAST PROLIFERATION 6 27 0.0007113 0.00503
659 HINDLIMB MORPHOGENESIS 7 37 0.0007258 0.005117
660 VIRION ASSEMBLY 7 37 0.0007258 0.005117
661 SINGLE ORGANISM BEHAVIOR 30 384 0.0007455 0.00524
662 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE 8 48 0.0007466 0.00524
663 POSITIVE REGULATION OF ACTIN FILAMENT BUNDLE ASSEMBLY 8 48 0.0007466 0.00524
664 NEGATIVE REGULATION OF CELL GROWTH 17 170 0.00075 0.00524
665 GLUCOSE HOMEOSTASIS 17 170 0.00075 0.00524
666 CARBOHYDRATE HOMEOSTASIS 17 170 0.00075 0.00524
667 REGULATION OF CELL PROJECTION ASSEMBLY 16 155 0.0007527 0.005251
668 HEMATOPOIETIC PROGENITOR CELL DIFFERENTIATION 12 98 0.000755 0.005259
669 REGULATION OF LIPID METABOLIC PROCESS 24 282 0.0007589 0.005276
670 CELLULAR HOMEOSTASIS 46 676 0.0007597 0.005276
671 ENERGY RESERVE METABOLIC PROCESS 10 72 0.000762 0.005284
672 CELL DIFFERENTIATION INVOLVED IN METANEPHROS DEVELOPMENT 4 11 0.0007761 0.00535
673 POSITIVE REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 4 11 0.0007761 0.00535
674 ERYTHROCYTE MATURATION 4 11 0.0007761 0.00535
675 REGULATION OF HISTONE H4 ACETYLATION 4 11 0.0007761 0.00535
676 TISSUE HOMEOSTASIS 17 171 0.0008014 0.005516
677 NEGATIVE REGULATION OF ION TRANSPORT 14 127 0.0008284 0.005693
678 REGULATION OF SYNAPSE ORGANIZATION 13 113 0.0008413 0.005765
679 ORGANOPHOSPHATE CATABOLIC PROCESS 13 113 0.0008413 0.005765
680 MODULATION OF SYNAPTIC TRANSMISSION 25 301 0.0008465 0.005792
681 ERYTHROCYTE HOMEOSTASIS 10 73 0.0008506 0.005803
682 MULTI ORGANISM REPRODUCTIVE PROCESS 57 891 0.0008497 0.005803
683 PIGMENTATION 11 86 0.000858 0.005845
684 POSITIVE REGULATION OF MULTI ORGANISM PROCESS 16 157 0.0008649 0.005884
685 NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR SIGNALING PATHWAY 6 28 0.0008738 0.005927
686 PLACENTA BLOOD VESSEL DEVELOPMENT 6 28 0.0008738 0.005927
687 CYTOPLASMIC SEQUESTERING OF TRANSCRIPTION FACTOR 5 19 0.0008793 0.005955
688 OVARIAN FOLLICLE DEVELOPMENT 9 61 0.0008887 0.00601
689 REGULATION OF LIPID BIOSYNTHETIC PROCESS 14 128 0.0008953 0.006046
690 MODIFICATION OF MORPHOLOGY OR PHYSIOLOGY OF OTHER ORGANISM 12 100 0.0009052 0.006096
691 PEPTIDYL TYROSINE DEPHOSPHORYLATION 12 100 0.0009052 0.006096
692 REGULATION OF CELL SUBSTRATE ADHESION 17 173 0.0009131 0.00614
693 DEPHOSPHORYLATION 24 286 0.0009236 0.006201
694 NEGATIVE REGULATION OF CELL DEVELOPMENT 25 303 0.0009303 0.006237
695 PEPTIDE METABOLIC PROCESS 40 571 0.0009549 0.006393
696 REGULATION OF PROTEIN STABILITY 20 221 0.00096 0.006418
697 STAT CASCADE 8 50 0.0009874 0.006582
698 JAK STAT CASCADE 8 50 0.0009874 0.006582
699 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 13 115 0.0009923 0.006587
700 CELLULAR CARBOHYDRATE METABOLIC PROCESS 15 144 0.0009904 0.006587
701 NEPHRON DEVELOPMENT 13 115 0.0009923 0.006587
702 PROTEIN DEPHOSPHORYLATION 18 190 0.001003 0.006636
703 PIGMENT METABOLIC PROCESS 9 62 0.001002 0.006636
704 LEUKOCYTE PROLIFERATION 11 88 0.001041 0.006873
705 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 11 88 0.001041 0.006873
706 SENSORY PERCEPTION OF PAIN 10 75 0.001053 0.006942
707 SECOND MESSENGER MEDIATED SIGNALING 16 160 0.00106 0.006974
708 PIGMENT CELL DIFFERENTIATION 6 29 0.001063 0.006979
709 REGULATION OF CGMP METABOLIC PROCESS 6 29 0.001063 0.006979
710 RENAL SYSTEM PROCESS 12 102 0.00108 0.007075
711 RESPONSE TO CORTICOSTEROID 17 176 0.001105 0.007234
712 CELLULAR CATABOLIC PROCESS 78 1322 0.001111 0.007262
713 UV PROTECTION 4 12 0.001126 0.0073
714 HEMATOPOIETIC STEM CELL DIFFERENTIATION 4 12 0.001126 0.0073
715 ANATOMICAL STRUCTURE REGRESSION 4 12 0.001126 0.0073
716 REGULATION OF CELLULAR RESPONSE TO VASCULAR ENDOTHELIAL GROWTH FACTOR STIMULUS 4 12 0.001126 0.0073
717 NEUROEPITHELIAL CELL DIFFERENTIATION 9 63 0.001127 0.0073
718 MYELIN MAINTENANCE 4 12 0.001126 0.0073
719 EMBRYONIC HEMOPOIESIS 5 20 0.001133 0.007309
720 CELLULAR RESPONSE TO GROWTH HORMONE STIMULUS 5 20 0.001133 0.007309
721 TRACHEA DEVELOPMENT 5 20 0.001133 0.007309
722 HEAD DEVELOPMENT 47 709 0.001155 0.007443
723 POSITIVE REGULATION OF CELL MATRIX ADHESION 7 40 0.00118 0.007591
724 NEGATIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 19 209 0.001205 0.007739
725 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 16 162 0.001209 0.007739
726 REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 16 162 0.001209 0.007739
727 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 16 162 0.001209 0.007739
728 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ORGANELLE 28 361 0.001228 0.007849
729 MESONEPHROS DEVELOPMENT 11 90 0.001256 0.008016
730 RESPONSE TO EPIDERMAL GROWTH FACTOR 6 30 0.001283 0.008144
731 RESPONSE TO GROWTH HORMONE 6 30 0.001283 0.008144
732 MYD88 INDEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 6 30 0.001283 0.008144
733 HYDROGEN PEROXIDE METABOLIC PROCESS 6 30 0.001283 0.008144
734 INTERACTION WITH SYMBIONT 8 52 0.001286 0.008155
735 DETOXIFICATION 10 77 0.001294 0.008192
736 POSITIVE REGULATION OF PURINE NUCLEOTIDE METABOLIC PROCESS 14 133 0.001302 0.008212
737 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 14 133 0.001302 0.008212
738 POSITIVE REGULATION OF NUCLEOTIDE METABOLIC PROCESS 14 133 0.001302 0.008212
739 POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 17 179 0.001331 0.008382
740 EAR DEVELOPMENT 18 195 0.001349 0.008483
741 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 7 41 0.001372 0.008569
742 CELL SUBSTRATE JUNCTION ASSEMBLY 7 41 0.001372 0.008569
743 MYELOID CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 7 41 0.001372 0.008569
744 REGULATION OF LEUKOCYTE DEGRANULATION 7 41 0.001372 0.008569
745 LACTATION 7 41 0.001372 0.008569
746 REGULATION OF CHROMOSOME ORGANIZATION 23 278 0.00141 0.008794
747 REGULATION OF CHEMOKINE PRODUCTION 9 65 0.001413 0.008803
748 INFLAMMATORY RESPONSE 33 454 0.001419 0.008827
749 SENSORY PERCEPTION OF TEMPERATURE STIMULUS 5 21 0.001436 0.008885
750 POSITIVE T CELL SELECTION 5 21 0.001436 0.008885
751 APOPTOTIC PROCESS INVOLVED IN DEVELOPMENT 5 21 0.001436 0.008885
752 NEGATIVE REGULATION OF PROTEIN ACETYLATION 5 21 0.001436 0.008885
753 NEGATIVE REGULATION OF PEPTIDASE ACTIVITY 21 245 0.001444 0.008921
754 NEURON PROJECTION EXTENSION 8 53 0.001461 0.009004
755 NEGATIVE REGULATION OF EPITHELIAL CELL MIGRATION 8 53 0.001461 0.009004
756 GLYCOSYL COMPOUND BIOSYNTHETIC PROCESS 13 120 0.001472 0.009059
757 EMBRYONIC ORGAN MORPHOGENESIS 23 279 0.001478 0.009085
758 POSITIVE REGULATION OF VIRAL PROCESS 11 92 0.001506 0.009242
759 FAT CELL DIFFERENTIATION 12 106 0.001513 0.009273
760 PYRIMIDINE NUCLEOTIDE BIOSYNTHETIC PROCESS 6 31 0.001536 0.009353
761 REGULATION OF PROTEIN TARGETING TO MEMBRANE 6 31 0.001536 0.009353
762 REGULATION OF DNA TEMPLATED TRANSCRIPTION INITIATION 6 31 0.001536 0.009353
763 MACROPHAGE ACTIVATION 6 31 0.001536 0.009353
764 SCHWANN CELL DIFFERENTIATION 6 31 0.001536 0.009353
765 DETECTION OF TEMPERATURE STIMULUS INVOLVED IN SENSORY PERCEPTION OF PAIN 4 13 0.001573 0.009543
766 REGULATION OF HISTONE PHOSPHORYLATION 4 13 0.001573 0.009543
767 DETECTION OF TEMPERATURE STIMULUS INVOLVED IN SENSORY PERCEPTION 4 13 0.001573 0.009543
768 NEGATIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 7 42 0.001588 0.009573
769 POSITIVE REGULATION OF DNA BINDING 7 42 0.001588 0.009573
770 REGULATION OF B CELL ACTIVATION 13 121 0.001588 0.009573
771 NEGATIVE REGULATION OF GTPASE ACTIVITY 7 42 0.001588 0.009573
772 NEGATIVE REGULATION OF IMMUNE RESPONSE 13 121 0.001588 0.009573
773 RESPONSE TO VIRUS 21 247 0.001596 0.00961
774 POSITIVE REGULATION OF LEUKOCYTE PROLIFERATION 14 136 0.001614 0.009701
775 NEPHRON EPITHELIUM DEVELOPMENT 11 93 0.001645 0.009875
776 B CELL RECEPTOR SIGNALING PATHWAY 8 54 0.001654 0.009915
NumGOOverlapSizeP ValueAdj. P Value
1 MOLECULAR FUNCTION REGULATOR 135 1353 5.531e-22 2.955e-19
2 RIBONUCLEOTIDE BINDING 166 1860 6.361e-22 2.955e-19
3 ENZYME BINDING 153 1737 1.348e-19 4.174e-17
4 KINASE BINDING 72 606 8.1e-16 1.881e-13
5 KINASE ACTIVITY 87 842 3.392e-15 6.303e-13
6 PROTEIN KINASE ACTIVITY 73 640 4.377e-15 6.777e-13
7 ADENYL NUCLEOTIDE BINDING 128 1514 5.384e-15 7.146e-13
8 ENZYME REGULATOR ACTIVITY 94 959 6.4e-15 7.432e-13
9 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 90 992 2.14e-12 2.209e-10
10 TRANSCRIPTION FACTOR BINDING 57 524 3.385e-11 3.144e-09
11 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 63 629 1.012e-10 8.548e-09
12 PROTEIN SERINE THREONINE KINASE ACTIVITY 50 445 1.814e-10 1.404e-08
13 IDENTICAL PROTEIN BINDING 96 1209 6.412e-10 4.582e-08
14 ENZYME ACTIVATOR ACTIVITY 50 471 1.304e-09 8.654e-08
15 MACROMOLECULAR COMPLEX BINDING 105 1399 2.15e-09 1.332e-07
16 GTPASE ACTIVITY 33 246 3.029e-09 1.759e-07
17 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 93 1199 3.979e-09 2.161e-07
18 NUCLEOSIDE TRIPHOSPHATASE REGULATOR ACTIVITY 39 329 4.187e-09 2.161e-07
19 PROTEIN TYROSINE KINASE ACTIVITY 26 176 1.938e-08 8.574e-07
20 REGULATORY REGION NUCLEIC ACID BINDING 69 818 1.892e-08 8.574e-07
21 GUANYL NUCLEOTIDE BINDING 42 390 1.838e-08 8.574e-07
22 KINASE REGULATOR ACTIVITY 26 186 6.131e-08 2.589e-06
23 PROTEIN COMPLEX BINDING 74 935 7.835e-08 3.164e-06
24 DOUBLE STRANDED DNA BINDING 64 764 8.177e-08 3.165e-06
25 HYDROLASE ACTIVITY ACTING ON ACID ANHYDRIDES 67 820 1.03e-07 3.827e-06
26 SEQUENCE SPECIFIC DNA BINDING 78 1037 2.775e-07 9.917e-06
27 RECEPTOR BINDING 101 1476 4.364e-07 1.502e-05
28 KINASE INHIBITOR ACTIVITY 16 89 7.149e-07 2.372e-05
29 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 32 303 1.394e-06 4.466e-05
30 CYTOSKELETAL PROTEIN BINDING 63 819 1.967e-06 6.09e-05
31 NON MEMBRANE SPANNING PROTEIN TYROSINE KINASE ACTIVITY 11 46 2.122e-06 6.16e-05
32 MOTOR ACTIVITY 19 131 2.06e-06 6.16e-05
33 RECEPTOR SIGNALING PROTEIN ACTIVITY 22 172 2.863e-06 8.061e-05
34 RECEPTOR SIGNALING PROTEIN SERINE THREONINE KINASE ACTIVITY 15 92 5.618e-06 0.0001535
35 PROTEIN DIMERIZATION ACTIVITY 78 1149 1.322e-05 0.0003509
36 PHOSPHATASE BINDING 20 162 1.366e-05 0.0003526
37 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 14 90 1.993e-05 0.0004873
38 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 31 328 1.943e-05 0.0004873
39 PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 8 30 2.245e-05 0.0005347
40 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 20 168 2.341e-05 0.0005438
41 PROTEIN HOMODIMERIZATION ACTIVITY 53 722 4.602e-05 0.001043
42 RNA POLYMERASE II CORE PROMOTER SEQUENCE SPECIFIC DNA BINDING 10 53 5.643e-05 0.001248
43 CORE PROMOTER BINDING 18 152 6.331e-05 0.001368
44 CORE PROMOTER SEQUENCE SPECIFIC DNA BINDING 14 101 7.415e-05 0.001566
45 PROTEIN C TERMINUS BINDING 20 186 1e-04 0.002065
46 ENZYME INHIBITOR ACTIVITY 32 378 0.0001207 0.002437
47 PROTEIN PHOSPHATASE BINDING 15 120 0.0001378 0.002724
48 ION CHANNEL BINDING 14 111 0.0002072 0.004009
49 DNA N GLYCOSYLASE ACTIVITY 5 15 0.0002608 0.00466
50 CALCIUM ION BINDING 49 697 0.0002474 0.00466
51 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 43 588 0.000256 0.00466
52 PROTEIN DOMAIN SPECIFIC BINDING 45 624 0.0002525 0.00466
53 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 27 315 0.0003276 0.005684
54 RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC DNA BINDING 10 65 0.0003304 0.005684
55 MITOGEN ACTIVATED PROTEIN KINASE BINDING 6 24 0.0003598 0.00593
56 RHO GTPASE BINDING 11 78 0.0003685 0.00593
57 PHOSPHORIC ESTER HYDROLASE ACTIVITY 30 368 0.0003702 0.00593
58 DEATH RECEPTOR ACTIVITY 6 24 0.0003598 0.00593
59 PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 18 178 0.0004647 0.007318
60 SCAFFOLD PROTEIN BINDING 8 45 0.000476 0.00737
61 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 21 226 0.0005134 0.007819
62 PHOSPHATASE ACTIVITY 24 275 0.0005314 0.007962
63 G PROTEIN COUPLED RECEPTOR BINDING 23 259 0.0005405 0.007971
64 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 21 228 0.0005765 0.008369
65 DRUG BINDING 13 109 0.0005964 0.008523
66 FRIZZLED BINDING 7 36 0.0006101 0.008588
67 GTPASE BINDING 25 295 0.0006332 0.00878
NumGOOverlapSizeP ValueAdj. P Value
1 CELL PROJECTION 134 1786 8.59e-12 5.017e-09
2 NEURON PROJECTION 84 942 3.02e-11 8.819e-09
3 NEURON PART 101 1265 1.6e-10 3.114e-08
4 CELL LEADING EDGE 43 350 2.154e-10 3.145e-08
5 INTRACELLULAR VESICLE 96 1259 5.18e-09 6.05e-07
6 CELL SUBSTRATE JUNCTION 43 398 1.13e-08 1.1e-06
7 PERINUCLEAR REGION OF CYTOPLASM 58 642 2.551e-08 1.782e-06
8 ENDOCYTIC VESICLE 32 256 2.942e-08 1.782e-06
9 CELL PROJECTION PART 76 946 2.777e-08 1.782e-06
10 RUFFLE 24 156 3.052e-08 1.782e-06
11 SIDE OF MEMBRANE 44 428 3.362e-08 1.785e-06
12 CYTOPLASMIC SIDE OF MEMBRANE 25 170 3.972e-08 1.933e-06
13 ANCHORING JUNCTION 47 489 8.989e-08 4.038e-06
14 CELL BODY 47 494 1.218e-07 5.08e-06
15 CYTOPLASMIC VESICLE PART 53 601 2.237e-07 8.709e-06
16 CYTOSKELETON 127 1967 3.023e-07 1.103e-05
17 EXTRINSIC COMPONENT OF CYTOPLASMIC SIDE OF PLASMA MEMBRANE 17 98 5.489e-07 1.886e-05
18 ACTIN CYTOSKELETON 42 444 6.676e-07 2.166e-05
19 SOMATODENDRITIC COMPARTMENT 54 650 1.117e-06 3.432e-05
20 EXTRACELLULAR SPACE 94 1376 1.229e-06 3.588e-05
21 EXTRINSIC COMPONENT OF PLASMA MEMBRANE 19 136 3.641e-06 0.0001013
22 LAMELLIPODIUM 21 172 9.977e-06 0.0002648
23 LEADING EDGE MEMBRANE 18 134 1.138e-05 0.0002889
24 ENDOCYTIC VESICLE MEMBRANE 19 152 1.866e-05 0.0004359
25 MYOSIN COMPLEX 12 67 1.808e-05 0.0004359
26 EXTRINSIC COMPONENT OF MEMBRANE 26 252 2.009e-05 0.0004512
27 CYTOSKELETAL PART 92 1436 2.126e-05 0.0004598
28 RUFFLE MEMBRANE 13 80 2.43e-05 0.0005067
29 MEMBRANE REGION 76 1134 2.652e-05 0.0005341
30 DENDRITE 38 451 3.199e-05 0.0006227
31 CELL PROJECTION MEMBRANE 28 298 5.367e-05 0.001011
32 VACUOLE 77 1180 5.72e-05 0.001044
33 CYTOSOLIC PART 23 223 5.969e-05 0.001056
34 MEMBRANE MICRODOMAIN 27 288 7.53e-05 0.001293
35 KINESIN COMPLEX 10 55 7.852e-05 0.00131
36 EXTRACELLULAR MATRIX 35 426 0.0001071 0.001691
37 VESICLE MEMBRANE 40 512 0.0001064 0.001691
38 VESICLE LUMEN 14 106 0.0001261 0.001905
39 CELL JUNCTION 74 1151 0.0001272 0.001905
40 CELL SURFACE 53 757 0.0001547 0.002259
41 GOLGI APPARATUS 88 1445 0.0001917 0.00273
42 MYELIN SHEATH 18 168 0.0002288 0.003181
43 CYTOSOLIC RIBOSOME 14 113 0.0002503 0.0034
44 INTRINSIC COMPONENT OF THE CYTOPLASMIC SIDE OF THE PLASMA MEMBRANE 5 15 0.0002608 0.003462
45 AXON 33 418 0.0003449 0.004476
46 SECRETORY GRANULE 29 352 0.0003876 0.004921
47 CYTOSOLIC SMALL RIBOSOMAL SUBUNIT 8 44 0.000406 0.005045
48 MICROTUBULE 32 405 0.0004154 0.005054
49 SITE OF POLARIZED GROWTH 16 149 0.0004874 0.005809
50 CLATHRIN ADAPTOR COMPLEX 6 27 0.0007113 0.008308
51 SECRETORY GRANULE LUMEN 11 85 0.0007769 0.008896
52 ENDOSOME 52 793 0.0008234 0.009248

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04010_MAPK_signaling_pathway 49 268 1.426e-18 2.523e-16
2 hsa04722_Neurotrophin_signaling_pathway 28 127 2.911e-13 2.576e-11
3 hsa04380_Osteoclast_differentiation 27 128 2.37e-12 1.398e-10
4 hsa04662_B_cell_receptor_signaling_pathway 20 75 1.775e-11 7.855e-10
5 hsa04910_Insulin_signaling_pathway 26 138 8.804e-11 3.117e-09
6 hsa04912_GnRH_signaling_pathway 22 101 1.319e-10 3.335e-09
7 hsa04916_Melanogenesis 22 101 1.319e-10 3.335e-09
8 hsa04062_Chemokine_signaling_pathway 29 189 1.206e-09 2.669e-08
9 hsa04370_VEGF_signaling_pathway 18 76 1.497e-09 2.944e-08
10 hsa04012_ErbB_signaling_pathway 18 87 1.494e-08 2.645e-07
11 hsa04660_T_cell_receptor_signaling_pathway 20 108 1.773e-08 2.732e-07
12 hsa04510_Focal_adhesion 28 200 1.852e-08 2.732e-07
13 hsa04310_Wnt_signaling_pathway 23 151 7.127e-08 9.704e-07
14 hsa04664_Fc_epsilon_RI_signaling_pathway 16 79 1.289e-07 1.629e-06
15 hsa04540_Gap_junction 17 90 1.532e-07 1.808e-06
16 hsa04620_Toll.like_receptor_signaling_pathway 18 102 1.957e-07 2.165e-06
17 hsa04270_Vascular_smooth_muscle_contraction 18 116 1.406e-06 1.464e-05
18 hsa04530_Tight_junction 19 133 2.597e-06 2.554e-05
19 hsa04144_Endocytosis 24 203 4.18e-06 3.894e-05
20 hsa04150_mTOR_signaling_pathway 11 52 7.648e-06 6.769e-05
21 hsa04810_Regulation_of_actin_cytoskeleton 24 214 1.038e-05 8.751e-05
22 hsa04914_Progesterone.mediated_oocyte_maturation 14 87 1.339e-05 0.0001077
23 hsa04650_Natural_killer_cell_mediated_cytotoxicity 18 136 1.4e-05 0.0001077
24 hsa04630_Jak.STAT_signaling_pathway 19 155 2.464e-05 0.0001817
25 hsa04720_Long.term_potentiation 12 70 2.86e-05 0.0002025
26 hsa04622_RIG.I.like_receptor_signaling_pathway 12 71 3.313e-05 0.0002256
27 hsa04666_Fc_gamma_R.mediated_phagocytosis 14 95 3.72e-05 0.0002438
28 hsa00230_Purine_metabolism 19 162 4.573e-05 0.0002891
29 hsa04210_Apoptosis 13 89 7.683e-05 0.0004689
30 hsa04670_Leukocyte_transendothelial_migration 15 117 0.0001032 0.0006018
31 hsa04920_Adipocytokine_signaling_pathway 11 68 0.0001059 0.0006018
32 hsa03010_Ribosome 13 92 0.0001088 0.0006018
33 hsa04730_Long.term_depression 11 70 0.0001386 0.0007434
34 hsa00983_Drug_metabolism_._other_enzymes 9 52 0.0002631 0.00137
35 hsa04360_Axon_guidance 15 130 0.0003355 0.001697
36 hsa00562_Inositol_phosphate_metabolism 9 57 0.0005345 0.002628
37 hsa00240_Pyrimidine_metabolism 12 99 0.0008272 0.003957
38 hsa04110_Cell_cycle 14 128 0.0008953 0.00417
39 hsa04744_Phototransduction 6 29 0.001063 0.004826
40 hsa04070_Phosphatidylinositol_signaling_system 10 78 0.00143 0.006328
41 hsa04623_Cytosolic_DNA.sensing_pathway 8 56 0.002099 0.009061
42 hsa04115_p53_signaling_pathway 9 69 0.002162 0.009113
43 hsa04330_Notch_signaling_pathway 7 47 0.003094 0.01274
44 hsa04130_SNARE_interactions_in_vesicular_transport 6 36 0.003406 0.0137
45 hsa04971_Gastric_acid_secretion 9 74 0.003509 0.0138
46 hsa04020_Calcium_signaling_pathway 15 177 0.0072 0.0277
47 hsa04340_Hedgehog_signaling_pathway 7 56 0.008273 0.03116
48 hsa04520_Adherens_junction 8 73 0.01073 0.03951
49 hsa04621_NOD.like_receptor_signaling_pathway 7 59 0.01094 0.03951
50 hsa03410_Base_excision_repair 5 34 0.01258 0.04454
51 hsa04114_Oocyte_meiosis 10 114 0.02052 0.07121
52 hsa04350_TGF.beta_signaling_pathway 8 85 0.02499 0.08506
53 hsa04960_Aldosterone.regulated_sodium_reabsorption 5 42 0.02935 0.09802
54 hsa04640_Hematopoietic_cell_lineage 8 88 0.02999 0.09831
55 hsa00460_Cyanoamino_acid_metabolism 2 7 0.03158 0.1005
56 hsa04970_Salivary_secretion 8 89 0.0318 0.1005
57 hsa04973_Carbohydrate_digestion_and_absorption 5 44 0.03504 0.1088
58 hsa04972_Pancreatic_secretion 8 101 0.05951 0.1816
59 hsa04145_Phagosome 11 156 0.0614 0.1842
60 hsa04142_Lysosome 9 121 0.06553 0.1933
61 hsa04976_Bile_secretion 6 71 0.0747 0.2167
62 hsa04320_Dorso.ventral_axis_formation 3 25 0.08372 0.239
63 hsa04962_Vasopressin.regulated_water_reabsorption 4 44 0.1093 0.3071
64 hsa03420_Nucleotide_excision_repair 4 45 0.1162 0.3215
65 hsa04512_ECM.receptor_interaction 6 85 0.1425 0.3881
66 hsa00040_Pentose_and_glucuronate_interconversions 3 32 0.1466 0.3931
67 hsa04614_Renin.angiotensin_system 2 17 0.156 0.4121
68 hsa04140_Regulation_of_autophagy 3 34 0.1668 0.4341
69 hsa00860_Porphyrin_and_chlorophyll_metabolism 3 43 0.265 0.674
70 hsa00970_Aminoacyl.tRNA_biosynthesis 4 63 0.2666 0.674
71 hsa00310_Lysine_degradation 3 44 0.2764 0.6892
72 hsa03050_Proteasome 3 45 0.2879 0.7077
73 hsa04975_Fat_digestion_and_absorption 3 46 0.2994 0.7259
74 hsa00052_Galactose_metabolism 2 27 0.3104 0.7424
75 hsa04672_Intestinal_immune_network_for_IgA_production 3 49 0.3339 0.7757
76 hsa04514_Cell_adhesion_molecules_.CAMs. 7 136 0.3375 0.7757
77 hsa00980_Metabolism_of_xenobiotics_by_cytochrome_P450 4 71 0.3421 0.7757
78 hsa00591_Linoleic_acid_metabolism 2 30 0.3566 0.7889
79 hsa04742_Taste_transduction 3 52 0.3684 0.8049
80 hsa00260_Glycine._serine_and_threonine_metabolism 2 32 0.3867 0.8223
81 hsa00500_Starch_and_sucrose_metabolism 3 54 0.3912 0.8223
82 hsa04260_Cardiac_muscle_contraction 4 77 0.3992 0.8223
83 hsa04141_Protein_processing_in_endoplasmic_reticulum 8 168 0.3995 0.8223
84 hsa03008_Ribosome_biogenesis_in_eukaryotes 4 81 0.4368 0.8888
85 hsa00565_Ether_lipid_metabolism 2 36 0.445 0.8892
86 hsa00590_Arachidonic_acid_metabolism 3 59 0.4471 0.8892
87 hsa03015_mRNA_surveillance_pathway 4 83 0.4554 0.8957
88 hsa00830_Retinol_metabolism 3 64 0.5009 0.9742
89 hsa00350_Tyrosine_metabolism 2 41 0.5134 0.9793
90 hsa04120_Ubiquitin_mediated_proteolysis 6 139 0.522 0.9829
91 hsa04610_Complement_and_coagulation_cascades 3 69 0.5518 1
92 hsa03320_PPAR_signaling_pathway 3 70 0.5616 1
93 hsa00982_Drug_metabolism_._cytochrome_P450 3 73 0.5903 1
94 hsa00480_Glutathione_metabolism 2 50 0.6215 1
95 hsa00561_Glycerolipid_metabolism 2 50 0.6215 1
96 hsa04612_Antigen_processing_and_presentation 3 78 0.6353 1
97 hsa00564_Glycerophospholipid_metabolism 3 80 0.6523 1
98 hsa04974_Protein_digestion_and_absorption 3 81 0.6606 1
99 hsa00330_Arginine_and_proline_metabolism 2 54 0.6633 1
100 hsa04146_Peroxisome 2 79 0.8462 1
101 hsa03013_RNA_transport 4 152 0.8816 1
102 hsa03040_Spliceosome 3 128 0.9057 1
103 hsa00190_Oxidative_phosphorylation 3 132 0.9163 1
104 hsa04740_Olfactory_transduction 7 388 0.997 1

Quest ID: 4c8e72a880aad0f65502beb2409aeed3