This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are
presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.
"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.
Num | microRNA | Gene | miRNA log2FC | miRNA pvalue | Gene log2FC | Gene pvalue | Interaction | Correlation beta | Correlation P-value | PMID | Reported in cancer studies |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | hsa-miR-27a-3p | A1CF | 0.25 | 0.02787 | -1.64 | 0.01422 | MirTarget | -1.22 | 0.00822 | NA | |
2 | hsa-miR-196b-5p | A2ML1 | 0.19 | 0.26231 | -1.28 | 0.1174 | MirTarget | -1.44 | 0.04437 | NA | |
3 | hsa-miR-146b-5p | ABCC13 | 0.36 | 0.20747 | -1.22 | 0.13482 | miRanda | -0.34 | 0.02054 | NA | |
4 | hsa-miR-199a-5p | ABCC3 | 0.71 | 0.03923 | -1.25 | 0.13146 | miRanda | -0.3 | 0.03124 | NA | |
5 | hsa-miR-145-5p | ABHD17B | 0.59 | 0.13573 | -1.43 | 0.09215 | MirTarget; miRNATAP | -0.58 | 0.00504 | NA | |
6 | hsa-miR-27a-3p | ABHD17B | 0.25 | 0.02787 | -1.43 | 0.09215 | miRNATAP | -1.82 | 0.03127 | NA | |
7 | hsa-miR-320a | ABHD3 | 0.13 | 0.34701 | -1.37 | 0.00856 | miRanda | -1.18 | 0.04786 | NA | |
8 | hsa-miR-361-5p | ABHD3 | 0.45 | 0.0617 | -1.37 | 0.00856 | PITA; miRanda | -0.63 | 0.03367 | NA | |
9 | hsa-miR-26a-5p | ABHD5 | 0.25 | 0.17155 | -2.89 | 0.06265 | MirTarget | -0.89 | 0.01875 | NA | |
10 | hsa-miR-199a-5p | ABI1 | 0.71 | 0.03923 | -0.02 | 0.98901 | miRanda | -0.39 | 0.03629 | NA | |
11 | hsa-miR-15b-5p | ABTB2 | 0.16 | 0.15019 | -1.52 | 0.20603 | MirTarget | -2.86 | 0.00522 | NA | |
12 | hsa-miR-331-3p | ABTB2 | 0.4 | 0.0084 | -1.52 | 0.20603 | MirTarget | -1.8 | 0.00337 | NA | |
13 | hsa-miR-429 | ACAD11 | -0.09 | 0.68169 | 0.47 | 0.45368 | miRanda | -1.04 | 0.04068 | NA | |
14 | hsa-miR-140-5p | ACER3 | 0.33 | 0.06517 | -0.93 | 0.22269 | miRanda | -0.5 | 0.0022 | NA | |
15 | hsa-miR-146b-5p | ACER3 | 0.36 | 0.20747 | -0.93 | 0.22269 | miRanda; mirMAP | -0.29 | 0.0046 | NA | |
16 | hsa-miR-150-5p | ACER3 | 0.26 | 0.33481 | -0.93 | 0.22269 | MirTarget | -0.33 | 0.00213 | NA | |
17 | hsa-miR-21-5p | ACER3 | 0.23 | 0.00828 | -0.93 | 0.22269 | mirMAP | -1.12 | 0.00895 | NA | |
18 | hsa-miR-320a | ACER3 | 0.13 | 0.34701 | -0.93 | 0.22269 | mirMAP | -0.53 | 0.0324 | NA | |
19 | hsa-miR-361-5p | ACER3 | 0.45 | 0.0617 | -0.93 | 0.22269 | mirMAP | -0.33 | 0.00531 | NA | |
20 | hsa-miR-146b-5p | ACOT8 | 0.36 | 0.20747 | -1.11 | 0.42123 | miRanda | -0.3 | 0.02845 | NA | |
21 | hsa-miR-320a | ACTG1 | 0.13 | 0.34701 | -0.4 | 0.7067 | miRNAWalker2 validate | -0.27 | 0.00042 | NA | |
22 | hsa-miR-331-3p | ACTG1 | 0.4 | 0.0084 | -0.4 | 0.7067 | miRNAWalker2 validate | -0.22 | 0.00056 | NA | |
23 | hsa-miR-34a-5p | ACTG1 | 0.19 | 0.17145 | -0.4 | 0.7067 | miRNAWalker2 validate | -0.21 | 0.00529 | NA | |
24 | hsa-miR-361-5p | ACTG1 | 0.45 | 0.0617 | -0.4 | 0.7067 | miRNAWalker2 validate; MirTarget; PITA; miRanda; miRNATAP | -0.13 | 0.00051 | NA | |
25 | hsa-miR-15b-5p | ACTR1A | 0.16 | 0.15019 | -0.43 | 0.67875 | miRNATAP | -0.83 | 0.01272 | NA | |
26 | hsa-miR-20a-5p | ACTR1A | 0.29 | 0.03283 | -0.43 | 0.67875 | miRNATAP | -0.49 | 0.0415 | NA | |
27 | hsa-miR-15b-5p | ACVR2A | 0.16 | 0.15019 | -1.27 | 0.11456 | MirTarget; miRNATAP | -1.88 | 0.04631 | NA | |
28 | hsa-miR-140-5p | ACVRL1 | 0.33 | 0.06517 | -1.67 | 0.04482 | mirMAP | -0.78 | 0.03686 | NA | |
29 | hsa-miR-199a-5p | ADAM11 | 0.71 | 0.03923 | -0.48 | 0.28458 | miRanda | -0.32 | 0.00927 | NA | |
30 | hsa-miR-320a | ADAM11 | 0.13 | 0.34701 | -0.48 | 0.28458 | miRanda | -0.78 | 0.03319 | NA | |
31 | hsa-miR-429 | ADAMTS10 | -0.09 | 0.68169 | -0.36 | 0.46298 | miRNATAP | -0.94 | 0.03177 | NA | |
32 | hsa-miR-26a-5p | ADAMTS17 | 0.25 | 0.17155 | -0.17 | 0.70513 | miRNATAP | -0.65 | 0.0334 | NA | |
33 | hsa-miR-27a-3p | ADGRG6 | 0.25 | 0.02787 | -3.6 | 0.02512 | miRNATAP | -1.87 | 0.00305 | NA | |
34 | hsa-miR-21-5p | AGO4 | 0.23 | 0.00828 | -0.38 | 0.56213 | miRNAWalker2 validate | -1.79 | 0.03385 | NA | |
35 | hsa-miR-96-5p | AGO4 | 0.23 | 0.38745 | -0.38 | 0.56213 | MirTarget; TargetScan | -0.46 | 0.03799 | NA | |
36 | hsa-miR-324-5p | AGTRAP | 0.58 | 0.02606 | -1.23 | 0.11718 | miRanda | -0.58 | 0.01776 | NA | |
37 | hsa-miR-15b-5p | AHRR | 0.16 | 0.15019 | -1.81 | 0.01799 | mirMAP | -1.42 | 0.03584 | NA | |
38 | hsa-miR-17-5p | AHRR | 0.44 | 0.00967 | -1.81 | 0.01799 | MirTarget; TargetScan | -0.74 | 0.0395 | NA | |
39 | hsa-miR-20a-5p | AHRR | 0.29 | 0.03283 | -1.81 | 0.01799 | MirTarget | -0.97 | 0.04241 | NA | |
40 | hsa-miR-96-5p | AHRR | 0.23 | 0.38745 | -1.81 | 0.01799 | mirMAP | -0.5 | 0.0325 | NA | |
41 | hsa-miR-21-5p | AHSA2 | 0.23 | 0.00828 | -2.45 | 0.01934 | miRNAWalker2 validate | -5.69 | 0.02164 | NA | |
42 | hsa-miR-338-3p | AIM1L | -0 | 0.98134 | 0 | 0 | miRanda | -0.48 | 0.00276 | NA | |
43 | hsa-miR-96-5p | AJAP1 | 0.23 | 0.38745 | -0.62 | 0.33251 | MirTarget; TargetScan | -0.63 | 0.01261 | NA | |
44 | hsa-miR-17-5p | AKAP13 | 0.44 | 0.00967 | -1.03 | 0.04078 | MirTarget; TargetScan; mirMAP; miRNATAP | -1.06 | 0.00939 | NA | |
45 | hsa-miR-20a-5p | AKAP13 | 0.29 | 0.03283 | -1.03 | 0.04078 | MirTarget; mirMAP; miRNATAP | -1.33 | 0.01444 | NA | |
46 | hsa-miR-140-5p | AKIRIN2 | 0.33 | 0.06517 | -0.28 | 0.72979 | miRanda; miRNATAP | -0.42 | 0.0462 | NA | |
47 | hsa-miR-34a-5p | ALDH9A1 | 0.19 | 0.17145 | -1.3 | 0.46922 | miRNAWalker2 validate | -2.51 | 0.0446 | NA | |
48 | hsa-miR-34a-5p | ALS2CL | 0.19 | 0.17145 | -0.68 | 0.56194 | MirTarget | -1.26 | 0.04874 | NA | |
49 | hsa-miR-630 | AMER2 | 0.17 | 0.10746 | -0.71 | 0.44428 | MirTarget | -1.55 | 0.02916 | NA | |
50 | hsa-miR-429 | ANGPT1 | -0.09 | 0.68169 | -0.07 | 0.91782 | miRanda | -0.95 | 0.00428 | NA | |
51 | hsa-miR-140-5p | ANK3 | 0.33 | 0.06517 | -1.54 | 0.03502 | miRanda | -0.51 | 0.03263 | NA | |
52 | hsa-miR-199a-5p | ANK3 | 0.71 | 0.03923 | -1.54 | 0.03502 | MirTarget; PITA; miRanda | -0.27 | 0.02189 | NA | |
53 | hsa-miR-27a-3p | ANK3 | 0.25 | 0.02787 | -1.54 | 0.03502 | MirTarget; miRNATAP | -1.18 | 0.00245 | NA | |
54 | hsa-miR-324-5p | ANK3 | 0.58 | 0.02606 | -1.54 | 0.03502 | miRanda | -0.49 | 0.00074 | NA | |
55 | hsa-miR-34a-5p | ANK3 | 0.19 | 0.17145 | -1.54 | 0.03502 | miRNATAP | -0.9 | 0.00422 | NA | |
56 | hsa-miR-630 | ANK3 | 0.17 | 0.10746 | -1.54 | 0.03502 | PITA; miRNATAP | -0.97 | 0.0356 | NA | |
57 | hsa-miR-17-5p | ANKRD12 | 0.44 | 0.00967 | -0.9 | 0.02817 | MirTarget; TargetScan | -0.64 | 0.01729 | NA | |
58 | hsa-miR-19a-3p | ANKRD12 | 0.29 | 0.05074 | -0.9 | 0.02817 | miRNATAP | -0.72 | 0.02617 | NA | |
59 | hsa-miR-20a-5p | ANKRD12 | 0.29 | 0.03283 | -0.9 | 0.02817 | MirTarget | -0.75 | 0.03828 | NA | |
60 | hsa-miR-625-3p | ANKRD20A2 | 0.71 | 0.00052 | -0.95 | 0.07774 | MirTarget | -0.32 | 0.04527 | NA | |
61 | hsa-miR-17-5p | ANKRD29 | 0.44 | 0.00967 | -0.78 | 0.39056 | MirTarget; TargetScan | -1.22 | 0.03362 | NA | |
62 | hsa-miR-20a-5p | ANKRD29 | 0.29 | 0.03283 | -0.78 | 0.39056 | MirTarget | -1.68 | 0.02687 | NA | |
63 | hsa-miR-361-5p | ANKRD33 | 0.45 | 0.0617 | -0.76 | 0.23562 | MirTarget; miRanda | -0.56 | 0.04939 | NA | |
64 | hsa-miR-199a-5p | ANO10 | 0.71 | 0.03923 | -2.39 | 0.0011 | miRanda | -0.53 | 0.04957 | NA | |
65 | hsa-miR-24-3p | ANPEP | 0.28 | 0.01927 | -1.38 | 0.02061 | miRNAWalker2 validate | -1.46 | 0.02357 | NA | |
66 | hsa-miR-150-5p | ANXA11 | 0.26 | 0.33481 | -0.54 | 0.53201 | mirMAP | -0.31 | 0.00834 | NA | |
67 | hsa-miR-30e-5p | ANXA11 | 0.06 | 0.69845 | -0.54 | 0.53201 | mirMAP | -0.52 | 0.01742 | NA | |
68 | hsa-miR-320a | ANXA11 | 0.13 | 0.34701 | -0.54 | 0.53201 | miRNAWalker2 validate | -0.58 | 0.02658 | NA | |
69 | hsa-miR-146b-5p | AP3S2 | 0.36 | 0.20747 | -0.43 | 0.70456 | mirMAP | -0.24 | 0.00086 | NA | |
70 | hsa-miR-150-5p | AP3S2 | 0.26 | 0.33481 | -0.43 | 0.70456 | mirMAP | -0.3 | 4.0E-5 | NA | |
71 | hsa-miR-21-3p | AP3S2 | 0.68 | 0.00116 | -0.43 | 0.70456 | mirMAP | -0.28 | 0.00244 | NA | |
72 | hsa-miR-30e-5p | AP3S2 | 0.06 | 0.69845 | -0.43 | 0.70456 | mirMAP | -0.43 | 0.00301 | NA | |
73 | hsa-miR-320a | AP3S2 | 0.13 | 0.34701 | -0.43 | 0.70456 | mirMAP | -0.39 | 0.02511 | NA | |
74 | hsa-miR-590-5p | APAF1 | 0.14 | 0.54667 | -0.09 | 0.90749 | miRanda | -0.78 | 0.04851 | NA | |
75 | hsa-miR-142-3p | APPL2 | 0.22 | 0.11381 | -1.37 | 0.06698 | miRanda | -2.06 | 0.03261 | NA | |
76 | hsa-miR-15b-5p | AQP11 | 0.16 | 0.15019 | -1.78 | 0.04756 | MirTarget | -1.81 | 0.04139 | NA | |
77 | hsa-miR-199a-5p | AQP11 | 0.71 | 0.03923 | -1.78 | 0.04756 | miRNATAP | -0.6 | 0.00543 | NA | |
78 | hsa-miR-27a-3p | AQP11 | 0.25 | 0.02787 | -1.78 | 0.04756 | MirTarget; miRNATAP | -1.88 | 0.01497 | NA | |
79 | hsa-miR-15b-5p | AQP2 | 0.16 | 0.15019 | 0.09 | 0.90688 | mirMAP | -2.27 | 0.04794 | NA | |
80 | hsa-miR-96-5p | AQP2 | 0.23 | 0.38745 | 0.09 | 0.90688 | MirTarget | -0.83 | 0.03572 | NA | |
81 | hsa-miR-145-5p | ARAP2 | 0.59 | 0.13573 | -2.08 | 0.00646 | MirTarget | -0.52 | 0.03056 | NA | |
82 | hsa-miR-199a-5p | ARC | 0.71 | 0.03923 | 0.26 | 0.82335 | miRanda | -0.47 | 0.03185 | NA | |
83 | hsa-miR-199a-5p | ARF6 | 0.71 | 0.03923 | -1.22 | 0.05489 | MirTarget; PITA; miRanda; miRNATAP | -0.24 | 0.025 | NA | |
84 | hsa-miR-34a-5p | ARF6 | 0.19 | 0.17145 | -1.22 | 0.05489 | miRNAWalker2 validate | -0.6 | 0.0491 | NA | |
85 | hsa-miR-320a | ARFRP1 | 0.13 | 0.34701 | -0.36 | 0.68863 | miRanda | -0.95 | 0.00634 | NA | |
86 | hsa-miR-331-3p | ARFRP1 | 0.4 | 0.0084 | -0.36 | 0.68863 | mirMAP | -0.65 | 0.02677 | NA | |
87 | hsa-miR-199a-5p | ARHGAP12 | 0.71 | 0.03923 | 0.78 | 0.62398 | PITA; miRanda; miRNATAP | -0.41 | 0.04544 | NA | |
88 | hsa-miR-146b-5p | ARHGAP26 | 0.36 | 0.20747 | -0.16 | 0.84788 | mirMAP | -0.39 | 0.00158 | NA | |
89 | hsa-miR-150-5p | ARHGAP26 | 0.26 | 0.33481 | -0.16 | 0.84788 | mirMAP | -0.44 | 0.00096 | NA | |
90 | hsa-miR-19a-3p | ARHGAP26 | 0.29 | 0.05074 | -0.16 | 0.84788 | mirMAP | -0.54 | 0.04084 | NA | |
91 | hsa-miR-21-3p | ARHGAP26 | 0.68 | 0.00116 | -0.16 | 0.84788 | mirMAP | -0.46 | 0.00379 | NA | |
92 | hsa-miR-24-3p | ARHGAP26 | 0.28 | 0.01927 | -0.16 | 0.84788 | MirTarget | -0.83 | 0.01373 | NA | |
93 | hsa-miR-26a-5p | ARHGAP26 | 0.25 | 0.17155 | -0.16 | 0.84788 | miRNATAP | -0.7 | 0.00051 | NA | |
94 | hsa-miR-30e-5p | ARHGAP26 | 0.06 | 0.69845 | -0.16 | 0.84788 | MirTarget | -0.66 | 0.00929 | NA | |
95 | hsa-miR-320a | ARHGAP26 | 0.13 | 0.34701 | -0.16 | 0.84788 | miRNAWalker2 validate; mirMAP | -0.81 | 0.00642 | NA | |
96 | hsa-miR-140-5p | ARHGEF18 | 0.33 | 0.06517 | -2.22 | 0.02833 | miRanda | -2.31 | 0.00881 | NA | |
97 | hsa-miR-17-5p | ARHGEF18 | 0.44 | 0.00967 | -2.22 | 0.02833 | TargetScan; miRNATAP | -1.91 | 0.04375 | NA | |
98 | hsa-miR-24-3p | ARHGEF18 | 0.28 | 0.01927 | -2.22 | 0.02833 | miRNAWalker2 validate | -3.45 | 0.01626 | NA | |
99 | hsa-miR-429 | ARHGEF25 | -0.09 | 0.68169 | 0.89 | 0.04529 | miRNATAP | -0.63 | 0.02131 | NA | |
100 | hsa-miR-145-5p | ARL5B | 0.59 | 0.13573 | -1.2 | 0.33643 | MirTarget | -0.33 | 0.02719 | NA | |
101 | hsa-miR-146b-5p | ARL5B | 0.36 | 0.20747 | -1.2 | 0.33643 | miRanda | -0.56 | 0.00737 | NA | |
102 | hsa-miR-30e-5p | ARL5B | 0.06 | 0.69845 | -1.2 | 0.33643 | mirMAP | -0.87 | 0.04114 | NA | |
103 | hsa-miR-625-3p | ARL5B | 0.71 | 0.00052 | -1.2 | 0.33643 | mirMAP | -0.62 | 0.0227 | NA | |
104 | hsa-miR-28-5p | ARMC7 | 0.14 | 0.34859 | 1.56 | 0.41454 | miRanda | -2.12 | 0.04371 | NA | |
105 | hsa-miR-146b-5p | ARRDC1 | 0.36 | 0.20747 | -2.57 | 0.17827 | miRanda | -0.29 | 0.00799 | NA | |
106 | hsa-miR-27a-3p | ARRDC4 | 0.25 | 0.02787 | -1.09 | 0.03723 | miRNATAP | -1.58 | 0.04441 | NA | |
107 | hsa-miR-27a-3p | ARX | 0.25 | 0.02787 | -1.15 | 0.06632 | miRNATAP | -2.04 | 0.00689 | NA | |
108 | hsa-miR-320a | ARX | 0.13 | 0.34701 | -1.15 | 0.06632 | miRanda | -1.64 | 0.00972 | NA | |
109 | hsa-miR-574-5p | ARX | 0.31 | 0.04403 | -1.15 | 0.06632 | PITA; miRNATAP | -1.55 | 0.00248 | NA | |
110 | hsa-miR-15b-5p | ASB6 | 0.16 | 0.15019 | 0 | 0 | mirMAP | -1.01 | 0.03348 | NA | |
111 | hsa-miR-96-5p | ASB6 | 0.23 | 0.38745 | 0 | 0 | TargetScan | -0.35 | 0.03514 | NA | |
112 | hsa-miR-140-5p | ASB7 | 0.33 | 0.06517 | -0.35 | 0.70485 | miRanda | -0.52 | 0.01166 | NA | |
113 | hsa-miR-142-3p | ASB7 | 0.22 | 0.11381 | -0.35 | 0.70485 | PITA; miRanda; miRNATAP | -0.74 | 0.01185 | NA | |
114 | hsa-miR-146b-5p | ASB7 | 0.36 | 0.20747 | -0.35 | 0.70485 | miRanda | -0.33 | 0.00995 | NA | |
115 | hsa-miR-320a | ASB7 | 0.13 | 0.34701 | -0.35 | 0.70485 | mirMAP | -0.74 | 0.01385 | NA | |
116 | hsa-miR-361-5p | ASB7 | 0.45 | 0.0617 | -0.35 | 0.70485 | miRanda | -0.4 | 0.0076 | NA | |
117 | hsa-miR-17-5p | ASPA | 0.44 | 0.00967 | -1.14 | 0.00823 | mirMAP | -0.93 | 0.00982 | NA | |
118 | hsa-miR-20a-5p | ASPA | 0.29 | 0.03283 | -1.14 | 0.00823 | mirMAP | -1.21 | 0.01178 | NA | |
119 | hsa-miR-324-5p | ASS1 | 0.58 | 0.02606 | -2.05 | 0.11854 | miRNAWalker2 validate | -0.53 | 0.01618 | NA | |
120 | hsa-miR-140-5p | ATG4A | 0.33 | 0.06517 | -2.06 | 0.00094 | miRanda | -1.14 | 0.01507 | NA | |
121 | hsa-miR-24-3p | ATG4A | 0.28 | 0.01927 | -2.06 | 0.00094 | MirTarget; miRNATAP | -1.87 | 0.01359 | 25426560 | Mir 24 3p downregulation contributes to VP16 DDP resistance in small cell lung cancer by targeting ATG4A; We further found that downregulated miR-24-3p enhanced autophagy activation as it directly targets and inhibits autophagy-associated gene 4A ATG4A; Overexpression of miR-24-3p into H446/EP cells led to reduction of the ATG4A protein level allowing SCLC cells to resensitize to VP16-DDP; We conclude that miR-24-3p regulates autophagy by targeting ATG4A |
122 | hsa-miR-142-3p | ATG4D | 0.22 | 0.11381 | -1.54 | 0.0788 | miRanda | -1.73 | 0.00918 | NA | |
123 | hsa-miR-199a-5p | ATG4D | 0.71 | 0.03923 | -1.54 | 0.0788 | miRNATAP | -0.5 | 0.03194 | NA | |
124 | hsa-miR-96-5p | ATG7 | 0.23 | 0.38745 | -1.79 | 0.12183 | TargetScan; miRNATAP | -0.64 | 0.0497 | 25333253 | Further studies have shown that high levels of miR-96 inhibited autophagy through suppressing ATG7 a key autophagy-associated gene; These data demonstrate hypoxia-induced autophagy is at least partially regulated by miR-96; miR-96 can promote or inhibit autophagy by principally inhibiting MTOR or ATG7 depending on the expression levels of miR-96 |
125 | hsa-miR-15b-5p | ATG9A | 0.16 | 0.15019 | -1.62 | 0.41711 | MirTarget | -3.45 | 0.00946 | NA | |
126 | hsa-miR-96-5p | ATG9A | 0.23 | 0.38745 | -1.62 | 0.41711 | TargetScan; miRNATAP | -1.09 | 0.0193 | NA | |
127 | hsa-miR-34a-5p | ATMIN | 0.19 | 0.17145 | 0 | 0 | MirTarget | -0.26 | 0.03462 | NA | |
128 | hsa-miR-17-5p | ATP1A2 | 0.44 | 0.00967 | -1.62 | 0.01031 | MirTarget; TargetScan | -1.48 | 0.04574 | NA | |
129 | hsa-miR-142-3p | ATP1B1 | 0.22 | 0.11381 | -0.08 | 0.96093 | PITA; miRanda; miRNATAP | -0.55 | 0.00332 | NA | |
130 | hsa-miR-29c-3p | ATP1B1 | -0.03 | 0.80456 | -0.08 | 0.96093 | miRNATAP | -0.66 | 0.0053 | NA | |
131 | hsa-miR-338-3p | ATP1B1 | -0 | 0.98134 | -0.08 | 0.96093 | miRanda | -0.45 | 0.00013 | NA | |
132 | hsa-miR-21-3p | ATP2B1 | 0.68 | 0.00116 | -2.15 | 0.00063 | MirTarget | -1.3 | 0.00242 | NA | |
133 | hsa-miR-24-3p | ATP2B1 | 0.28 | 0.01927 | -2.15 | 0.00063 | MirTarget | -2.12 | 0.01968 | NA | |
134 | hsa-miR-27a-3p | ATP2B1 | 0.25 | 0.02787 | -2.15 | 0.00063 | miRNATAP | -2.1 | 0.03212 | NA | |
135 | hsa-miR-590-5p | ATP5SL | 0.14 | 0.54667 | 0 | 0 | miRanda | -0.48 | 0.00492 | NA | |
136 | hsa-miR-429 | ATP6V1B2 | -0.09 | 0.68169 | 1.85 | 0.05277 | miRNATAP | -1.25 | 0.02212 | NA | |
137 | hsa-miR-17-5p | ATXN7 | 0.44 | 0.00967 | -0.57 | 0.30246 | miRNAWalker2 validate | -0.62 | 0.03908 | NA | |
138 | hsa-miR-19a-3p | ATXN7 | 0.29 | 0.05074 | -0.57 | 0.30246 | MirTarget; miRNATAP | -0.83 | 0.01961 | NA | |
139 | hsa-miR-26a-5p | ATXN7 | 0.25 | 0.17155 | -0.57 | 0.30246 | miRNATAP | -0.59 | 0.04803 | NA | |
140 | hsa-miR-324-5p | ATXN7 | 0.58 | 0.02606 | -0.57 | 0.30246 | MirTarget; miRanda; miRNATAP | -0.4 | 0.03614 | NA | |
141 | hsa-miR-361-5p | B2M | 0.45 | 0.0617 | -1.3 | 0.02328 | miRanda | -0.63 | 0.02227 | NA | |
142 | hsa-miR-24-3p | B3GALT5 | 0.28 | 0.01927 | -2.45 | 0.01578 | MirTarget | -1.42 | 0.04864 | NA | |
143 | hsa-miR-142-3p | B3GNT5 | 0.22 | 0.11381 | -1.83 | 0.13612 | miRanda | -2.06 | 0.00547 | NA | |
144 | hsa-miR-146b-5p | B3GNT5 | 0.36 | 0.20747 | -1.83 | 0.13612 | miRanda | -0.83 | 0.01129 | NA | |
145 | hsa-miR-26a-5p | B3GNT5 | 0.25 | 0.17155 | -1.83 | 0.13612 | MirTarget | -1.4 | 0.00936 | NA | |
146 | hsa-miR-140-5p | B4GALT1 | 0.33 | 0.06517 | -1.31 | 0.10447 | PITA | -0.96 | 0.02207 | NA | |
147 | hsa-miR-26a-5p | B4GALT1 | 0.25 | 0.17155 | -1.31 | 0.10447 | miRNATAP | -1.25 | 0.0025 | NA | |
148 | hsa-miR-30e-5p | B4GALT1 | 0.06 | 0.69845 | -1.31 | 0.10447 | mirMAP | -1.34 | 0.00787 | NA | |
149 | hsa-miR-140-5p | BACH1 | 0.33 | 0.06517 | 0.05 | 0.963 | MirTarget; PITA; miRanda; miRNATAP | -0.48 | 0.04325 | NA | |
150 | hsa-miR-142-3p | BACH1 | 0.22 | 0.11381 | 0.05 | 0.963 | MirTarget; PITA; miRanda; miRNATAP | -0.76 | 0.02221 | NA |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | INTRACELLULAR SIGNAL TRANSDUCTION | 115 | 1572 | 2.604e-09 | 1.212e-05 |
2 | PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS | 130 | 1977 | 1.32e-07 | 0.0003072 |
3 | EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY | 13 | 55 | 3.259e-07 | 0.0005054 |
4 | EXTRINSIC APOPTOTIC SIGNALING PATHWAY | 17 | 99 | 7.276e-07 | 0.0008464 |
5 | APOPTOTIC SIGNALING PATHWAY | 31 | 289 | 1.782e-06 | 0.001658 |
6 | POSITIVE REGULATION OF HYDROLASE ACTIVITY | 68 | 905 | 2.423e-06 | 0.001879 |
7 | ERBB SIGNALING PATHWAY | 14 | 79 | 4.678e-06 | 0.00311 |
8 | POSITIVE REGULATION OF MOLECULAR FUNCTION | 113 | 1791 | 6.984e-06 | 0.003611 |
9 | CELLULAR LIPID METABOLIC PROCESS | 67 | 913 | 6.345e-06 | 0.003611 |
10 | LAYER FORMATION IN CEREBRAL CORTEX | 6 | 14 | 1.212e-05 | 0.005639 |
11 | POSITIVE REGULATION OF CATALYTIC ACTIVITY | 97 | 1518 | 2.034e-05 | 0.007135 |
12 | PROTEIN PHOSPHORYLATION | 67 | 944 | 1.865e-05 | 0.007135 |
13 | LIPID BIOSYNTHETIC PROCESS | 44 | 539 | 2.147e-05 | 0.007135 |
14 | PHOSPHORYLATION | 82 | 1228 | 2.027e-05 | 0.007135 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | KINASE ACTIVITY | 66 | 842 | 8.063e-07 | 0.0003745 |
2 | TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS | 75 | 992 | 5.663e-07 | 0.0003745 |
3 | RIBONUCLEOTIDE BINDING | 118 | 1860 | 3.266e-06 | 0.001011 |
4 | KINASE BINDING | 50 | 606 | 4.432e-06 | 0.001013 |
5 | PROTEIN SERINE THREONINE KINASE ACTIVITY | 40 | 445 | 5.454e-06 | 0.001013 |
6 | SODIUM ION BINDING | 6 | 14 | 1.212e-05 | 0.001876 |
7 | ALKALI METAL ION BINDING | 7 | 21 | 1.559e-05 | 0.002069 |
8 | PROTEIN KINASE ACTIVITY | 48 | 640 | 7.83e-05 | 0.008729 |
9 | GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY | 28 | 303 | 8.456e-05 | 0.008729 |
10 | RHO GTPASE BINDING | 12 | 78 | 9.43e-05 | 0.00876 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | MEMBRANE REGION | 89 | 1134 | 8.034e-09 | 4.692e-06 |
2 | CELL JUNCTION | 86 | 1151 | 1.324e-07 | 3.866e-05 |
3 | NEURON PART | 91 | 1265 | 3.053e-07 | 5.943e-05 |
4 | PLASMA MEMBRANE REGION | 69 | 929 | 3.044e-06 | 0.0004444 |
5 | NEURON PROJECTION | 68 | 942 | 9.315e-06 | 0.001088 |
6 | DENDRITE | 39 | 451 | 1.742e-05 | 0.001696 |
7 | VACUOLE | 79 | 1180 | 2.647e-05 | 0.001932 |
8 | SYNAPSE PART | 48 | 610 | 2.373e-05 | 0.001932 |
9 | EXTRINSIC COMPONENT OF MEMBRANE | 25 | 252 | 6.441e-05 | 0.004179 |
10 | BASOLATERAL PLASMA MEMBRANE | 22 | 211 | 8.379e-05 | 0.004662 |
11 | EXCITATORY SYNAPSE | 21 | 197 | 8.781e-05 | 0.004662 |
12 | CELL PROJECTION | 107 | 1786 | 0.000105 | 0.004878 |
13 | CELL PROJECTION PART | 64 | 946 | 0.0001169 | 0.004878 |
14 | SOMATODENDRITIC COMPARTMENT | 48 | 650 | 0.0001136 | 0.004878 |
15 | SITE OF POLARIZED GROWTH | 17 | 149 | 0.0001779 | 0.006925 |
16 | CYTOPLASMIC REGION | 26 | 287 | 0.0002052 | 0.00705 |
17 | AXON | 34 | 418 | 0.0001934 | 0.00705 |
18 | APICAL JUNCTION COMPLEX | 15 | 128 | 0.0003135 | 0.009402 |
19 | POSTSYNAPSE | 31 | 378 | 0.0003163 | 0.009402 |
20 | SYNAPSE | 52 | 754 | 0.000322 | 0.009402 |
Num | Pathway | Pathview | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|---|
1 | Tight_junction_hsa04530 | 20 | 170 | 3.186e-05 | 0.001657 | |
2 | Endocytosis_hsa04144 | 23 | 244 | 0.0002647 | 0.006882 | |
3 | Apoptosis_hsa04210 | 15 | 138 | 0.0007014 | 0.009834 | |
4 | Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 | 15 | 139 | 0.0007565 | 0.009834 | |
5 | Phospholipase_D_signaling_pathway_hsa04072 | 15 | 146 | 0.001254 | 0.01304 | |
6 | Apoptosis_multiple_species_hsa04215 | 6 | 33 | 0.002259 | 0.0176 | |
7 | Autophagy_animal_hsa04140 | 13 | 128 | 0.002854 | 0.0176 | |
8 | Phosphatidylinositol_signaling_system_hsa04070 | 11 | 99 | 0.002924 | 0.0176 | |
9 | Regulation_of_actin_cytoskeleton_hsa04810 | 18 | 208 | 0.003047 | 0.0176 | |
10 | Focal_adhesion_hsa04510 | 17 | 199 | 0.004462 | 0.0232 | |
11 | Wnt_signaling_pathway_hsa04310 | 13 | 146 | 0.00863 | 0.03459 | |
12 | ErbB_signaling_pathway_hsa04012 | 9 | 85 | 0.009275 | 0.03459 | |
13 | HIF_1_signaling_pathway_hsa04066 | 10 | 100 | 0.009289 | 0.03459 | |
14 | Ras_signaling_pathway_hsa04014 | 18 | 232 | 0.009313 | 0.03459 | |
15 | Autophagy_other_hsa04136 | 5 | 32 | 0.01013 | 0.03513 | |
16 | Rap1_signaling_pathway_hsa04015 | 16 | 206 | 0.01357 | 0.0441 | |
17 | Mitophagy_animal_hsa04137 | 7 | 65 | 0.01892 | 0.05787 | |
18 | Sphingolipid_signaling_pathway_hsa04071 | 10 | 118 | 0.02689 | 0.07768 | |
19 | Hippo_signaling_pathway_hsa04390 | 12 | 154 | 0.02923 | 0.07798 | |
20 | Adherens_junction_hsa04520 | 7 | 72 | 0.03122 | 0.07798 | |
21 | Gap_junction_hsa04540 | 8 | 88 | 0.03149 | 0.07798 | |
22 | TNF_signaling_pathway_hsa04668 | 9 | 108 | 0.03802 | 0.08987 | |
23 | PI3K_Akt_signaling_pathway_hsa04151 | 22 | 352 | 0.0419 | 0.09425 | |
24 | MAPK_signaling_pathway_hsa04010 | 19 | 295 | 0.0435 | 0.09425 | |
25 | mTOR_signaling_pathway_hsa04150 | 11 | 151 | 0.05373 | 0.1118 | |
26 | TGF_beta_signaling_pathway_hsa04350 | 7 | 84 | 0.0629 | 0.1258 | |
27 | Jak_STAT_signaling_pathway_hsa04630 | 11 | 162 | 0.0799 | 0.1531 | |
28 | Cell_adhesion_molecules_.CAMs._hsa04514 | 10 | 145 | 0.08501 | 0.1531 | |
29 | Necroptosis_hsa04217 | 11 | 164 | 0.08539 | 0.1531 | |
30 | VEGF_signaling_pathway_hsa04370 | 5 | 59 | 0.1013 | 0.1755 | |
31 | cAMP_signaling_pathway_hsa04024 | 12 | 198 | 0.1303 | 0.2186 | |
32 | cGMP_PKG_signaling_pathway_hsa04022 | 10 | 163 | 0.1489 | 0.2419 | |
33 | p53_signaling_pathway_hsa04115 | 5 | 68 | 0.1569 | 0.2472 | |
34 | Cellular_senescence_hsa04218 | 9 | 160 | 0.2311 | 0.3507 | |
35 | Calcium_signaling_pathway_hsa04020 | 10 | 182 | 0.2361 | 0.3507 | |
36 | AMPK_signaling_pathway_hsa04152 | 7 | 121 | 0.2465 | 0.356 | |
37 | ECM_receptor_interaction_hsa04512 | 5 | 82 | 0.2615 | 0.3675 | |
38 | FoxO_signaling_pathway_hsa04068 | 7 | 132 | 0.319 | 0.4366 | |
39 | Hippo_signaling_pathway_multiple_species_hsa04392 | 2 | 29 | 0.3456 | 0.4592 | |
40 | Apelin_signaling_pathway_hsa04371 | 7 | 137 | 0.3532 | 0.4592 | |
41 | Oocyte_meiosis_hsa04114 | 6 | 124 | 0.4213 | 0.5344 | |
42 | NF_kappa_B_signaling_pathway_hsa04064 | 4 | 95 | 0.5692 | 0.7047 | |
43 | Lysosome_hsa04142 | 5 | 123 | 0.593 | 0.7144 | |
44 | Notch_signaling_pathway_hsa04330 | 2 | 48 | 0.6045 | 0.7144 | |
45 | Neuroactive_ligand_receptor_interaction_hsa04080 | 11 | 278 | 0.6232 | 0.7201 | |
46 | Cytokine_cytokine_receptor_interaction_hsa04060 | 10 | 270 | 0.7019 | 0.7935 | |
47 | Cell_cycle_hsa04110 | 4 | 124 | 0.7699 | 0.8343 | |
48 | Phagosome_hsa04145 | 5 | 152 | 0.7701 | 0.8343 |