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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-27a-3p A1CF 0.25 0.02787 -1.64 0.01422 MirTarget -1.22 0.00822 NA
2 hsa-miR-196b-5p A2ML1 0.19 0.26231 -1.28 0.1174 MirTarget -1.44 0.04437 NA
3 hsa-miR-146b-5p ABCC13 0.36 0.20747 -1.22 0.13482 miRanda -0.34 0.02054 NA
4 hsa-miR-199a-5p ABCC3 0.71 0.03923 -1.25 0.13146 miRanda -0.3 0.03124 NA
5 hsa-miR-145-5p ABHD17B 0.59 0.13573 -1.43 0.09215 MirTarget; miRNATAP -0.58 0.00504 NA
6 hsa-miR-27a-3p ABHD17B 0.25 0.02787 -1.43 0.09215 miRNATAP -1.82 0.03127 NA
7 hsa-miR-320a ABHD3 0.13 0.34701 -1.37 0.00856 miRanda -1.18 0.04786 NA
8 hsa-miR-361-5p ABHD3 0.45 0.0617 -1.37 0.00856 PITA; miRanda -0.63 0.03367 NA
9 hsa-miR-26a-5p ABHD5 0.25 0.17155 -2.89 0.06265 MirTarget -0.89 0.01875 NA
10 hsa-miR-199a-5p ABI1 0.71 0.03923 -0.02 0.98901 miRanda -0.39 0.03629 NA
11 hsa-miR-15b-5p ABTB2 0.16 0.15019 -1.52 0.20603 MirTarget -2.86 0.00522 NA
12 hsa-miR-331-3p ABTB2 0.4 0.0084 -1.52 0.20603 MirTarget -1.8 0.00337 NA
13 hsa-miR-429 ACAD11 -0.09 0.68169 0.47 0.45368 miRanda -1.04 0.04068 NA
14 hsa-miR-140-5p ACER3 0.33 0.06517 -0.93 0.22269 miRanda -0.5 0.0022 NA
15 hsa-miR-146b-5p ACER3 0.36 0.20747 -0.93 0.22269 miRanda; mirMAP -0.29 0.0046 NA
16 hsa-miR-150-5p ACER3 0.26 0.33481 -0.93 0.22269 MirTarget -0.33 0.00213 NA
17 hsa-miR-21-5p ACER3 0.23 0.00828 -0.93 0.22269 mirMAP -1.12 0.00895 NA
18 hsa-miR-320a ACER3 0.13 0.34701 -0.93 0.22269 mirMAP -0.53 0.0324 NA
19 hsa-miR-361-5p ACER3 0.45 0.0617 -0.93 0.22269 mirMAP -0.33 0.00531 NA
20 hsa-miR-146b-5p ACOT8 0.36 0.20747 -1.11 0.42123 miRanda -0.3 0.02845 NA
21 hsa-miR-320a ACTG1 0.13 0.34701 -0.4 0.7067 miRNAWalker2 validate -0.27 0.00042 NA
22 hsa-miR-331-3p ACTG1 0.4 0.0084 -0.4 0.7067 miRNAWalker2 validate -0.22 0.00056 NA
23 hsa-miR-34a-5p ACTG1 0.19 0.17145 -0.4 0.7067 miRNAWalker2 validate -0.21 0.00529 NA
24 hsa-miR-361-5p ACTG1 0.45 0.0617 -0.4 0.7067 miRNAWalker2 validate; MirTarget; PITA; miRanda; miRNATAP -0.13 0.00051 NA
25 hsa-miR-15b-5p ACTR1A 0.16 0.15019 -0.43 0.67875 miRNATAP -0.83 0.01272 NA
26 hsa-miR-20a-5p ACTR1A 0.29 0.03283 -0.43 0.67875 miRNATAP -0.49 0.0415 NA
27 hsa-miR-15b-5p ACVR2A 0.16 0.15019 -1.27 0.11456 MirTarget; miRNATAP -1.88 0.04631 NA
28 hsa-miR-140-5p ACVRL1 0.33 0.06517 -1.67 0.04482 mirMAP -0.78 0.03686 NA
29 hsa-miR-199a-5p ADAM11 0.71 0.03923 -0.48 0.28458 miRanda -0.32 0.00927 NA
30 hsa-miR-320a ADAM11 0.13 0.34701 -0.48 0.28458 miRanda -0.78 0.03319 NA
31 hsa-miR-429 ADAMTS10 -0.09 0.68169 -0.36 0.46298 miRNATAP -0.94 0.03177 NA
32 hsa-miR-26a-5p ADAMTS17 0.25 0.17155 -0.17 0.70513 miRNATAP -0.65 0.0334 NA
33 hsa-miR-27a-3p ADGRG6 0.25 0.02787 -3.6 0.02512 miRNATAP -1.87 0.00305 NA
34 hsa-miR-21-5p AGO4 0.23 0.00828 -0.38 0.56213 miRNAWalker2 validate -1.79 0.03385 NA
35 hsa-miR-96-5p AGO4 0.23 0.38745 -0.38 0.56213 MirTarget; TargetScan -0.46 0.03799 NA
36 hsa-miR-324-5p AGTRAP 0.58 0.02606 -1.23 0.11718 miRanda -0.58 0.01776 NA
37 hsa-miR-15b-5p AHRR 0.16 0.15019 -1.81 0.01799 mirMAP -1.42 0.03584 NA
38 hsa-miR-17-5p AHRR 0.44 0.00967 -1.81 0.01799 MirTarget; TargetScan -0.74 0.0395 NA
39 hsa-miR-20a-5p AHRR 0.29 0.03283 -1.81 0.01799 MirTarget -0.97 0.04241 NA
40 hsa-miR-96-5p AHRR 0.23 0.38745 -1.81 0.01799 mirMAP -0.5 0.0325 NA
41 hsa-miR-21-5p AHSA2 0.23 0.00828 -2.45 0.01934 miRNAWalker2 validate -5.69 0.02164 NA
42 hsa-miR-338-3p AIM1L -0 0.98134 0 0 miRanda -0.48 0.00276 NA
43 hsa-miR-96-5p AJAP1 0.23 0.38745 -0.62 0.33251 MirTarget; TargetScan -0.63 0.01261 NA
44 hsa-miR-17-5p AKAP13 0.44 0.00967 -1.03 0.04078 MirTarget; TargetScan; mirMAP; miRNATAP -1.06 0.00939 NA
45 hsa-miR-20a-5p AKAP13 0.29 0.03283 -1.03 0.04078 MirTarget; mirMAP; miRNATAP -1.33 0.01444 NA
46 hsa-miR-140-5p AKIRIN2 0.33 0.06517 -0.28 0.72979 miRanda; miRNATAP -0.42 0.0462 NA
47 hsa-miR-34a-5p ALDH9A1 0.19 0.17145 -1.3 0.46922 miRNAWalker2 validate -2.51 0.0446 NA
48 hsa-miR-34a-5p ALS2CL 0.19 0.17145 -0.68 0.56194 MirTarget -1.26 0.04874 NA
49 hsa-miR-630 AMER2 0.17 0.10746 -0.71 0.44428 MirTarget -1.55 0.02916 NA
50 hsa-miR-429 ANGPT1 -0.09 0.68169 -0.07 0.91782 miRanda -0.95 0.00428 NA
51 hsa-miR-140-5p ANK3 0.33 0.06517 -1.54 0.03502 miRanda -0.51 0.03263 NA
52 hsa-miR-199a-5p ANK3 0.71 0.03923 -1.54 0.03502 MirTarget; PITA; miRanda -0.27 0.02189 NA
53 hsa-miR-27a-3p ANK3 0.25 0.02787 -1.54 0.03502 MirTarget; miRNATAP -1.18 0.00245 NA
54 hsa-miR-324-5p ANK3 0.58 0.02606 -1.54 0.03502 miRanda -0.49 0.00074 NA
55 hsa-miR-34a-5p ANK3 0.19 0.17145 -1.54 0.03502 miRNATAP -0.9 0.00422 NA
56 hsa-miR-630 ANK3 0.17 0.10746 -1.54 0.03502 PITA; miRNATAP -0.97 0.0356 NA
57 hsa-miR-17-5p ANKRD12 0.44 0.00967 -0.9 0.02817 MirTarget; TargetScan -0.64 0.01729 NA
58 hsa-miR-19a-3p ANKRD12 0.29 0.05074 -0.9 0.02817 miRNATAP -0.72 0.02617 NA
59 hsa-miR-20a-5p ANKRD12 0.29 0.03283 -0.9 0.02817 MirTarget -0.75 0.03828 NA
60 hsa-miR-625-3p ANKRD20A2 0.71 0.00052 -0.95 0.07774 MirTarget -0.32 0.04527 NA
61 hsa-miR-17-5p ANKRD29 0.44 0.00967 -0.78 0.39056 MirTarget; TargetScan -1.22 0.03362 NA
62 hsa-miR-20a-5p ANKRD29 0.29 0.03283 -0.78 0.39056 MirTarget -1.68 0.02687 NA
63 hsa-miR-361-5p ANKRD33 0.45 0.0617 -0.76 0.23562 MirTarget; miRanda -0.56 0.04939 NA
64 hsa-miR-199a-5p ANO10 0.71 0.03923 -2.39 0.0011 miRanda -0.53 0.04957 NA
65 hsa-miR-24-3p ANPEP 0.28 0.01927 -1.38 0.02061 miRNAWalker2 validate -1.46 0.02357 NA
66 hsa-miR-150-5p ANXA11 0.26 0.33481 -0.54 0.53201 mirMAP -0.31 0.00834 NA
67 hsa-miR-30e-5p ANXA11 0.06 0.69845 -0.54 0.53201 mirMAP -0.52 0.01742 NA
68 hsa-miR-320a ANXA11 0.13 0.34701 -0.54 0.53201 miRNAWalker2 validate -0.58 0.02658 NA
69 hsa-miR-146b-5p AP3S2 0.36 0.20747 -0.43 0.70456 mirMAP -0.24 0.00086 NA
70 hsa-miR-150-5p AP3S2 0.26 0.33481 -0.43 0.70456 mirMAP -0.3 4.0E-5 NA
71 hsa-miR-21-3p AP3S2 0.68 0.00116 -0.43 0.70456 mirMAP -0.28 0.00244 NA
72 hsa-miR-30e-5p AP3S2 0.06 0.69845 -0.43 0.70456 mirMAP -0.43 0.00301 NA
73 hsa-miR-320a AP3S2 0.13 0.34701 -0.43 0.70456 mirMAP -0.39 0.02511 NA
74 hsa-miR-590-5p APAF1 0.14 0.54667 -0.09 0.90749 miRanda -0.78 0.04851 NA
75 hsa-miR-142-3p APPL2 0.22 0.11381 -1.37 0.06698 miRanda -2.06 0.03261 NA
76 hsa-miR-15b-5p AQP11 0.16 0.15019 -1.78 0.04756 MirTarget -1.81 0.04139 NA
77 hsa-miR-199a-5p AQP11 0.71 0.03923 -1.78 0.04756 miRNATAP -0.6 0.00543 NA
78 hsa-miR-27a-3p AQP11 0.25 0.02787 -1.78 0.04756 MirTarget; miRNATAP -1.88 0.01497 NA
79 hsa-miR-15b-5p AQP2 0.16 0.15019 0.09 0.90688 mirMAP -2.27 0.04794 NA
80 hsa-miR-96-5p AQP2 0.23 0.38745 0.09 0.90688 MirTarget -0.83 0.03572 NA
81 hsa-miR-145-5p ARAP2 0.59 0.13573 -2.08 0.00646 MirTarget -0.52 0.03056 NA
82 hsa-miR-199a-5p ARC 0.71 0.03923 0.26 0.82335 miRanda -0.47 0.03185 NA
83 hsa-miR-199a-5p ARF6 0.71 0.03923 -1.22 0.05489 MirTarget; PITA; miRanda; miRNATAP -0.24 0.025 NA
84 hsa-miR-34a-5p ARF6 0.19 0.17145 -1.22 0.05489 miRNAWalker2 validate -0.6 0.0491 NA
85 hsa-miR-320a ARFRP1 0.13 0.34701 -0.36 0.68863 miRanda -0.95 0.00634 NA
86 hsa-miR-331-3p ARFRP1 0.4 0.0084 -0.36 0.68863 mirMAP -0.65 0.02677 NA
87 hsa-miR-199a-5p ARHGAP12 0.71 0.03923 0.78 0.62398 PITA; miRanda; miRNATAP -0.41 0.04544 NA
88 hsa-miR-146b-5p ARHGAP26 0.36 0.20747 -0.16 0.84788 mirMAP -0.39 0.00158 NA
89 hsa-miR-150-5p ARHGAP26 0.26 0.33481 -0.16 0.84788 mirMAP -0.44 0.00096 NA
90 hsa-miR-19a-3p ARHGAP26 0.29 0.05074 -0.16 0.84788 mirMAP -0.54 0.04084 NA
91 hsa-miR-21-3p ARHGAP26 0.68 0.00116 -0.16 0.84788 mirMAP -0.46 0.00379 NA
92 hsa-miR-24-3p ARHGAP26 0.28 0.01927 -0.16 0.84788 MirTarget -0.83 0.01373 NA
93 hsa-miR-26a-5p ARHGAP26 0.25 0.17155 -0.16 0.84788 miRNATAP -0.7 0.00051 NA
94 hsa-miR-30e-5p ARHGAP26 0.06 0.69845 -0.16 0.84788 MirTarget -0.66 0.00929 NA
95 hsa-miR-320a ARHGAP26 0.13 0.34701 -0.16 0.84788 miRNAWalker2 validate; mirMAP -0.81 0.00642 NA
96 hsa-miR-140-5p ARHGEF18 0.33 0.06517 -2.22 0.02833 miRanda -2.31 0.00881 NA
97 hsa-miR-17-5p ARHGEF18 0.44 0.00967 -2.22 0.02833 TargetScan; miRNATAP -1.91 0.04375 NA
98 hsa-miR-24-3p ARHGEF18 0.28 0.01927 -2.22 0.02833 miRNAWalker2 validate -3.45 0.01626 NA
99 hsa-miR-429 ARHGEF25 -0.09 0.68169 0.89 0.04529 miRNATAP -0.63 0.02131 NA
100 hsa-miR-145-5p ARL5B 0.59 0.13573 -1.2 0.33643 MirTarget -0.33 0.02719 NA
101 hsa-miR-146b-5p ARL5B 0.36 0.20747 -1.2 0.33643 miRanda -0.56 0.00737 NA
102 hsa-miR-30e-5p ARL5B 0.06 0.69845 -1.2 0.33643 mirMAP -0.87 0.04114 NA
103 hsa-miR-625-3p ARL5B 0.71 0.00052 -1.2 0.33643 mirMAP -0.62 0.0227 NA
104 hsa-miR-28-5p ARMC7 0.14 0.34859 1.56 0.41454 miRanda -2.12 0.04371 NA
105 hsa-miR-146b-5p ARRDC1 0.36 0.20747 -2.57 0.17827 miRanda -0.29 0.00799 NA
106 hsa-miR-27a-3p ARRDC4 0.25 0.02787 -1.09 0.03723 miRNATAP -1.58 0.04441 NA
107 hsa-miR-27a-3p ARX 0.25 0.02787 -1.15 0.06632 miRNATAP -2.04 0.00689 NA
108 hsa-miR-320a ARX 0.13 0.34701 -1.15 0.06632 miRanda -1.64 0.00972 NA
109 hsa-miR-574-5p ARX 0.31 0.04403 -1.15 0.06632 PITA; miRNATAP -1.55 0.00248 NA
110 hsa-miR-15b-5p ASB6 0.16 0.15019 0 0 mirMAP -1.01 0.03348 NA
111 hsa-miR-96-5p ASB6 0.23 0.38745 0 0 TargetScan -0.35 0.03514 NA
112 hsa-miR-140-5p ASB7 0.33 0.06517 -0.35 0.70485 miRanda -0.52 0.01166 NA
113 hsa-miR-142-3p ASB7 0.22 0.11381 -0.35 0.70485 PITA; miRanda; miRNATAP -0.74 0.01185 NA
114 hsa-miR-146b-5p ASB7 0.36 0.20747 -0.35 0.70485 miRanda -0.33 0.00995 NA
115 hsa-miR-320a ASB7 0.13 0.34701 -0.35 0.70485 mirMAP -0.74 0.01385 NA
116 hsa-miR-361-5p ASB7 0.45 0.0617 -0.35 0.70485 miRanda -0.4 0.0076 NA
117 hsa-miR-17-5p ASPA 0.44 0.00967 -1.14 0.00823 mirMAP -0.93 0.00982 NA
118 hsa-miR-20a-5p ASPA 0.29 0.03283 -1.14 0.00823 mirMAP -1.21 0.01178 NA
119 hsa-miR-324-5p ASS1 0.58 0.02606 -2.05 0.11854 miRNAWalker2 validate -0.53 0.01618 NA
120 hsa-miR-140-5p ATG4A 0.33 0.06517 -2.06 0.00094 miRanda -1.14 0.01507 NA
121 hsa-miR-24-3p ATG4A 0.28 0.01927 -2.06 0.00094 MirTarget; miRNATAP -1.87 0.01359 25426560 Mir 24 3p downregulation contributes to VP16 DDP resistance in small cell lung cancer by targeting ATG4A; We further found that downregulated miR-24-3p enhanced autophagy activation as it directly targets and inhibits autophagy-associated gene 4A ATG4A; Overexpression of miR-24-3p into H446/EP cells led to reduction of the ATG4A protein level allowing SCLC cells to resensitize to VP16-DDP; We conclude that miR-24-3p regulates autophagy by targeting ATG4A
122 hsa-miR-142-3p ATG4D 0.22 0.11381 -1.54 0.0788 miRanda -1.73 0.00918 NA
123 hsa-miR-199a-5p ATG4D 0.71 0.03923 -1.54 0.0788 miRNATAP -0.5 0.03194 NA
124 hsa-miR-96-5p ATG7 0.23 0.38745 -1.79 0.12183 TargetScan; miRNATAP -0.64 0.0497 25333253 Further studies have shown that high levels of miR-96 inhibited autophagy through suppressing ATG7 a key autophagy-associated gene; These data demonstrate hypoxia-induced autophagy is at least partially regulated by miR-96; miR-96 can promote or inhibit autophagy by principally inhibiting MTOR or ATG7 depending on the expression levels of miR-96
125 hsa-miR-15b-5p ATG9A 0.16 0.15019 -1.62 0.41711 MirTarget -3.45 0.00946 NA
126 hsa-miR-96-5p ATG9A 0.23 0.38745 -1.62 0.41711 TargetScan; miRNATAP -1.09 0.0193 NA
127 hsa-miR-34a-5p ATMIN 0.19 0.17145 0 0 MirTarget -0.26 0.03462 NA
128 hsa-miR-17-5p ATP1A2 0.44 0.00967 -1.62 0.01031 MirTarget; TargetScan -1.48 0.04574 NA
129 hsa-miR-142-3p ATP1B1 0.22 0.11381 -0.08 0.96093 PITA; miRanda; miRNATAP -0.55 0.00332 NA
130 hsa-miR-29c-3p ATP1B1 -0.03 0.80456 -0.08 0.96093 miRNATAP -0.66 0.0053 NA
131 hsa-miR-338-3p ATP1B1 -0 0.98134 -0.08 0.96093 miRanda -0.45 0.00013 NA
132 hsa-miR-21-3p ATP2B1 0.68 0.00116 -2.15 0.00063 MirTarget -1.3 0.00242 NA
133 hsa-miR-24-3p ATP2B1 0.28 0.01927 -2.15 0.00063 MirTarget -2.12 0.01968 NA
134 hsa-miR-27a-3p ATP2B1 0.25 0.02787 -2.15 0.00063 miRNATAP -2.1 0.03212 NA
135 hsa-miR-590-5p ATP5SL 0.14 0.54667 0 0 miRanda -0.48 0.00492 NA
136 hsa-miR-429 ATP6V1B2 -0.09 0.68169 1.85 0.05277 miRNATAP -1.25 0.02212 NA
137 hsa-miR-17-5p ATXN7 0.44 0.00967 -0.57 0.30246 miRNAWalker2 validate -0.62 0.03908 NA
138 hsa-miR-19a-3p ATXN7 0.29 0.05074 -0.57 0.30246 MirTarget; miRNATAP -0.83 0.01961 NA
139 hsa-miR-26a-5p ATXN7 0.25 0.17155 -0.57 0.30246 miRNATAP -0.59 0.04803 NA
140 hsa-miR-324-5p ATXN7 0.58 0.02606 -0.57 0.30246 MirTarget; miRanda; miRNATAP -0.4 0.03614 NA
141 hsa-miR-361-5p B2M 0.45 0.0617 -1.3 0.02328 miRanda -0.63 0.02227 NA
142 hsa-miR-24-3p B3GALT5 0.28 0.01927 -2.45 0.01578 MirTarget -1.42 0.04864 NA
143 hsa-miR-142-3p B3GNT5 0.22 0.11381 -1.83 0.13612 miRanda -2.06 0.00547 NA
144 hsa-miR-146b-5p B3GNT5 0.36 0.20747 -1.83 0.13612 miRanda -0.83 0.01129 NA
145 hsa-miR-26a-5p B3GNT5 0.25 0.17155 -1.83 0.13612 MirTarget -1.4 0.00936 NA
146 hsa-miR-140-5p B4GALT1 0.33 0.06517 -1.31 0.10447 PITA -0.96 0.02207 NA
147 hsa-miR-26a-5p B4GALT1 0.25 0.17155 -1.31 0.10447 miRNATAP -1.25 0.0025 NA
148 hsa-miR-30e-5p B4GALT1 0.06 0.69845 -1.31 0.10447 mirMAP -1.34 0.00787 NA
149 hsa-miR-140-5p BACH1 0.33 0.06517 0.05 0.963 MirTarget; PITA; miRanda; miRNATAP -0.48 0.04325 NA
150 hsa-miR-142-3p BACH1 0.22 0.11381 0.05 0.963 MirTarget; PITA; miRanda; miRNATAP -0.76 0.02221 NA
NumGOOverlapSizeP ValueAdj. P Value
1 INTRACELLULAR SIGNAL TRANSDUCTION 115 1572 2.604e-09 1.212e-05
2 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 130 1977 1.32e-07 0.0003072
3 EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 13 55 3.259e-07 0.0005054
4 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 17 99 7.276e-07 0.0008464
5 APOPTOTIC SIGNALING PATHWAY 31 289 1.782e-06 0.001658
6 POSITIVE REGULATION OF HYDROLASE ACTIVITY 68 905 2.423e-06 0.001879
7 ERBB SIGNALING PATHWAY 14 79 4.678e-06 0.00311
8 POSITIVE REGULATION OF MOLECULAR FUNCTION 113 1791 6.984e-06 0.003611
9 CELLULAR LIPID METABOLIC PROCESS 67 913 6.345e-06 0.003611
10 LAYER FORMATION IN CEREBRAL CORTEX 6 14 1.212e-05 0.005639
11 POSITIVE REGULATION OF CATALYTIC ACTIVITY 97 1518 2.034e-05 0.007135
12 PROTEIN PHOSPHORYLATION 67 944 1.865e-05 0.007135
13 LIPID BIOSYNTHETIC PROCESS 44 539 2.147e-05 0.007135
14 PHOSPHORYLATION 82 1228 2.027e-05 0.007135
NumGOOverlapSizeP ValueAdj. P Value
1 KINASE ACTIVITY 66 842 8.063e-07 0.0003745
2 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 75 992 5.663e-07 0.0003745
3 RIBONUCLEOTIDE BINDING 118 1860 3.266e-06 0.001011
4 KINASE BINDING 50 606 4.432e-06 0.001013
5 PROTEIN SERINE THREONINE KINASE ACTIVITY 40 445 5.454e-06 0.001013
6 SODIUM ION BINDING 6 14 1.212e-05 0.001876
7 ALKALI METAL ION BINDING 7 21 1.559e-05 0.002069
8 PROTEIN KINASE ACTIVITY 48 640 7.83e-05 0.008729
9 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 28 303 8.456e-05 0.008729
10 RHO GTPASE BINDING 12 78 9.43e-05 0.00876
NumGOOverlapSizeP ValueAdj. P Value
1 MEMBRANE REGION 89 1134 8.034e-09 4.692e-06
2 CELL JUNCTION 86 1151 1.324e-07 3.866e-05
3 NEURON PART 91 1265 3.053e-07 5.943e-05
4 PLASMA MEMBRANE REGION 69 929 3.044e-06 0.0004444
5 NEURON PROJECTION 68 942 9.315e-06 0.001088
6 DENDRITE 39 451 1.742e-05 0.001696
7 VACUOLE 79 1180 2.647e-05 0.001932
8 SYNAPSE PART 48 610 2.373e-05 0.001932
9 EXTRINSIC COMPONENT OF MEMBRANE 25 252 6.441e-05 0.004179
10 BASOLATERAL PLASMA MEMBRANE 22 211 8.379e-05 0.004662
11 EXCITATORY SYNAPSE 21 197 8.781e-05 0.004662
12 CELL PROJECTION 107 1786 0.000105 0.004878
13 CELL PROJECTION PART 64 946 0.0001169 0.004878
14 SOMATODENDRITIC COMPARTMENT 48 650 0.0001136 0.004878
15 SITE OF POLARIZED GROWTH 17 149 0.0001779 0.006925
16 CYTOPLASMIC REGION 26 287 0.0002052 0.00705
17 AXON 34 418 0.0001934 0.00705
18 APICAL JUNCTION COMPLEX 15 128 0.0003135 0.009402
19 POSTSYNAPSE 31 378 0.0003163 0.009402
20 SYNAPSE 52 754 0.000322 0.009402

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Tight_junction_hsa04530 20 170 3.186e-05 0.001657
2 Endocytosis_hsa04144 23 244 0.0002647 0.006882
3 Apoptosis_hsa04210 15 138 0.0007014 0.009834
4 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 15 139 0.0007565 0.009834
5 Phospholipase_D_signaling_pathway_hsa04072 15 146 0.001254 0.01304
6 Apoptosis_multiple_species_hsa04215 6 33 0.002259 0.0176
7 Autophagy_animal_hsa04140 13 128 0.002854 0.0176
8 Phosphatidylinositol_signaling_system_hsa04070 11 99 0.002924 0.0176
9 Regulation_of_actin_cytoskeleton_hsa04810 18 208 0.003047 0.0176
10 Focal_adhesion_hsa04510 17 199 0.004462 0.0232
11 Wnt_signaling_pathway_hsa04310 13 146 0.00863 0.03459
12 ErbB_signaling_pathway_hsa04012 9 85 0.009275 0.03459
13 HIF_1_signaling_pathway_hsa04066 10 100 0.009289 0.03459
14 Ras_signaling_pathway_hsa04014 18 232 0.009313 0.03459
15 Autophagy_other_hsa04136 5 32 0.01013 0.03513
16 Rap1_signaling_pathway_hsa04015 16 206 0.01357 0.0441
17 Mitophagy_animal_hsa04137 7 65 0.01892 0.05787
18 Sphingolipid_signaling_pathway_hsa04071 10 118 0.02689 0.07768
19 Hippo_signaling_pathway_hsa04390 12 154 0.02923 0.07798
20 Adherens_junction_hsa04520 7 72 0.03122 0.07798
21 Gap_junction_hsa04540 8 88 0.03149 0.07798
22 TNF_signaling_pathway_hsa04668 9 108 0.03802 0.08987
23 PI3K_Akt_signaling_pathway_hsa04151 22 352 0.0419 0.09425
24 MAPK_signaling_pathway_hsa04010 19 295 0.0435 0.09425
25 mTOR_signaling_pathway_hsa04150 11 151 0.05373 0.1118
26 TGF_beta_signaling_pathway_hsa04350 7 84 0.0629 0.1258
27 Jak_STAT_signaling_pathway_hsa04630 11 162 0.0799 0.1531
28 Cell_adhesion_molecules_.CAMs._hsa04514 10 145 0.08501 0.1531
29 Necroptosis_hsa04217 11 164 0.08539 0.1531
30 VEGF_signaling_pathway_hsa04370 5 59 0.1013 0.1755
31 cAMP_signaling_pathway_hsa04024 12 198 0.1303 0.2186
32 cGMP_PKG_signaling_pathway_hsa04022 10 163 0.1489 0.2419
33 p53_signaling_pathway_hsa04115 5 68 0.1569 0.2472
34 Cellular_senescence_hsa04218 9 160 0.2311 0.3507
35 Calcium_signaling_pathway_hsa04020 10 182 0.2361 0.3507
36 AMPK_signaling_pathway_hsa04152 7 121 0.2465 0.356
37 ECM_receptor_interaction_hsa04512 5 82 0.2615 0.3675
38 FoxO_signaling_pathway_hsa04068 7 132 0.319 0.4366
39 Hippo_signaling_pathway_multiple_species_hsa04392 2 29 0.3456 0.4592
40 Apelin_signaling_pathway_hsa04371 7 137 0.3532 0.4592
41 Oocyte_meiosis_hsa04114 6 124 0.4213 0.5344
42 NF_kappa_B_signaling_pathway_hsa04064 4 95 0.5692 0.7047
43 Lysosome_hsa04142 5 123 0.593 0.7144
44 Notch_signaling_pathway_hsa04330 2 48 0.6045 0.7144
45 Neuroactive_ligand_receptor_interaction_hsa04080 11 278 0.6232 0.7201
46 Cytokine_cytokine_receptor_interaction_hsa04060 10 270 0.7019 0.7935
47 Cell_cycle_hsa04110 4 124 0.7699 0.8343
48 Phagosome_hsa04145 5 152 0.7701 0.8343

Quest ID: 4e3fecb7a19e3d1809359331431c2658