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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-106a-5p AKT3 -0.2 0.80221 0.46 0.53933 miRNATAP -0.55 0 NA
2 hsa-miR-106b-5p AKT3 -0.3 0.86929 0.46 0.53933 miRNATAP -0.91 0 NA
3 hsa-miR-107 AKT3 -0.04 0.98836 0.46 0.53933 PITA; miRanda -0.55 0.00017 NA
4 hsa-miR-1275 AKT3 -0.83 0.08038 0.46 0.53933 PITA -0.27 0 NA
5 hsa-miR-142-3p AKT3 -0.15 0.9461 0.46 0.53933 miRanda -0.2 0.00627 NA
6 hsa-miR-15a-5p AKT3 -0.07 0.96484 0.46 0.53933 miRNAWalker2 validate; miRTarBase; miRNATAP -0.72 0 NA
7 hsa-miR-15b-5p AKT3 -0.27 0.87097 0.46 0.53933 miRNATAP -0.67 0 NA
8 hsa-miR-16-5p AKT3 0.01 0.99448 0.46 0.53933 miRNAWalker2 validate; miRTarBase; miRNATAP -0.75 0 NA
9 hsa-miR-17-3p AKT3 0.1 0.96011 0.46 0.53933 miRNATAP -0.52 0 NA
10 hsa-miR-17-5p AKT3 -0.18 0.93454 0.46 0.53933 TargetScan; miRNATAP -0.63 0 NA
11 hsa-miR-181b-5p AKT3 0.16 0.93018 0.46 0.53933 miRNATAP -0.27 0.00963 NA
12 hsa-miR-20a-5p AKT3 -0.18 0.92812 0.46 0.53933 miRNATAP -0.53 0 NA
13 hsa-miR-28-3p AKT3 -0.23 0.93535 0.46 0.53933 miRNATAP -0.52 0.00719 NA
14 hsa-miR-29a-3p AKT3 0.01 0.99698 0.46 0.53933 miRNATAP -0.81 0 NA
15 hsa-miR-29b-3p AKT3 -0.1 0.95899 0.46 0.53933 miRNATAP -0.68 0 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
16 hsa-miR-32-3p AKT3 -0.57 0.13133 0.46 0.53933 mirMAP -0.56 0 NA
17 hsa-miR-320a AKT3 -0.42 0.8402 0.46 0.53933 PITA; miRanda; miRNATAP -0.33 0.00138 NA
18 hsa-miR-320b AKT3 -0.24 0.85922 0.46 0.53933 PITA; miRanda; miRNATAP -0.25 0.00855 NA
19 hsa-miR-335-3p AKT3 -0.24 0.8845 0.46 0.53933 mirMAP -0.58 0 NA
20 hsa-miR-33a-3p AKT3 -0.79 0.01052 0.46 0.53933 mirMAP -0.49 0 NA
21 hsa-miR-340-5p AKT3 -0 0.99757 0.46 0.53933 mirMAP -0.28 0.006 NA
22 hsa-miR-362-3p AKT3 -0.72 0.03459 0.46 0.53933 miRanda -0.42 0 NA
23 hsa-miR-362-5p AKT3 -0.27 0.75202 0.46 0.53933 PITA; TargetScan; miRNATAP -0.52 0 NA
24 hsa-miR-369-3p AKT3 0.12 0.8323 0.46 0.53933 mirMAP -0.23 0.00901 NA
25 hsa-miR-374a-5p AKT3 -0.34 0.76692 0.46 0.53933 mirMAP -0.58 0 NA
26 hsa-miR-374b-5p AKT3 -0.29 0.8357 0.46 0.53933 mirMAP -0.68 0 NA
27 hsa-miR-421 AKT3 -0.18 0.7347 0.46 0.53933 miRanda; mirMAP -0.46 0 NA
28 hsa-miR-424-5p AKT3 0.25 0.87015 0.46 0.53933 miRNATAP -0.24 0.00104 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth
29 hsa-miR-501-3p AKT3 -0.75 0.55276 0.46 0.53933 miRNATAP -0.5 0 NA
30 hsa-miR-502-3p AKT3 -0.48 0.5143 0.46 0.53933 miRNATAP -0.64 0 NA
31 hsa-miR-502-5p AKT3 -0.71 0.02613 0.46 0.53933 PITA; miRNATAP -0.41 0 NA
32 hsa-miR-505-3p AKT3 -0.47 0.69038 0.46 0.53933 mirMAP -0.77 0 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR
33 hsa-miR-548o-3p AKT3 -0.19 0.51773 0.46 0.53933 mirMAP -0.31 8.0E-5 NA
34 hsa-miR-577 AKT3 -1.06 0.32606 0.46 0.53933 mirMAP -0.38 0 NA
35 hsa-miR-663b AKT3 0.1 0.81499 0.46 0.53933 PITA -0.25 1.0E-5 NA
36 hsa-miR-769-5p AKT3 -0.31 0.7357 0.46 0.53933 PITA; miRNATAP -0.84 0 NA
37 hsa-miR-93-5p AKT3 -0.61 0.8253 0.46 0.53933 miRNATAP -0.76 0 NA
38 hsa-miR-708-3p APAF1 0.14 0.89698 -0.17 0.88665 mirMAP -0.11 0.0011 NA
39 hsa-miR-324-5p ATM -0.5 0.53742 0.19 0.86463 miRanda -0.12 0.00155 NA
40 hsa-miR-455-5p ATM -0.14 0.86574 0.19 0.86463 miRanda -0.12 0.00128 NA
41 hsa-miR-590-5p ATM -0.55 0.47274 0.19 0.86463 mirMAP -0.1 0.00142 NA
42 hsa-miR-17-5p BCL2 -0.18 0.93454 -0.87 0.24496 miRNAWalker2 validate; miRTarBase -0.31 2.0E-5 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2
43 hsa-miR-192-5p BCL2 -0.12 0.97293 -0.87 0.24496 miRNAWalker2 validate -0.23 0.00056 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192
44 hsa-miR-196b-5p BCL2 -0.08 0.97211 -0.87 0.24496 miRNAWalker2 validate -0.13 0.00926 NA
45 hsa-miR-20a-3p BCL2 0.46 0.57674 -0.87 0.24496 mirMAP -0.19 0.00115 NA
46 hsa-miR-20a-5p BCL2 -0.18 0.92812 -0.87 0.24496 miRNAWalker2 validate; miRTarBase -0.25 0.00046 NA
47 hsa-miR-224-3p BCL2 0.11 0.74909 -0.87 0.24496 mirMAP -0.18 0.00775 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01
48 hsa-miR-224-5p BCL2 -0.24 0.85735 -0.87 0.24496 mirMAP -0.3 0 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01
49 hsa-miR-24-2-5p BCL2 -0.09 0.92016 -0.87 0.24496 miRNAWalker2 validate; miRTarBase -0.41 0.00012 NA
50 hsa-miR-29a-3p BCL2 0.01 0.99698 -0.87 0.24496 miRNAWalker2 validate; miRTarBase -0.34 0.00194 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29
51 hsa-miR-29a-5p BCL2 -0.32 0.60044 -0.87 0.24496 mirMAP -0.34 1.0E-5 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29
52 hsa-miR-29b-3p BCL2 -0.1 0.95899 -0.87 0.24496 miRNAWalker2 validate; miRTarBase -0.27 0.00119 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29
53 hsa-miR-335-3p BCL2 -0.24 0.8845 -0.87 0.24496 mirMAP -0.25 0.00118 NA
54 hsa-miR-33a-5p BCL2 -0.21 0.85331 -0.87 0.24496 mirMAP -0.13 0.00456 NA
55 hsa-miR-450b-5p BCL2 -0.01 0.98315 -0.87 0.24496 mirMAP -0.24 0.00586 NA
56 hsa-miR-452-5p BCL2 -0.05 0.97387 -0.87 0.24496 mirMAP -0.28 0.00061 NA
57 hsa-miR-7-5p BCL2 0.21 0.77371 -0.87 0.24496 miRNAWalker2 validate; miRTarBase; mirMAP -0.2 0.00018 26464649; 25862909; 21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions
58 hsa-let-7a-5p BCL2L1 -0.06 0.98501 0.24 0.89096 TargetScan; miRNATAP -0.27 0.0015 26915294; 20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA
59 hsa-miR-126-5p BIRC2 0.08 0.95664 -0.01 0.9934 mirMAP -0.12 0.00073 NA
60 hsa-miR-24-1-5p BIRC3 -0.19 0.79153 -0.14 0.89724 MirTarget -0.31 0.00145 NA
61 hsa-miR-651-5p BIRC3 -0.57 0.17254 -0.14 0.89724 MirTarget -0.16 0.00706 NA
62 hsa-miR-20a-3p CAPN2 0.46 0.57674 0.04 0.98149 MirTarget -0.11 0.00146 NA
63 hsa-miR-421 CAPN2 -0.18 0.7347 0.04 0.98149 miRanda -0.25 0 NA
64 hsa-miR-7-5p CAPN2 0.21 0.77371 0.04 0.98149 miRNAWalker2 validate -0.12 0.0001 NA
65 hsa-miR-181c-5p CASP10 0.04 0.96916 -0.29 0.80713 mirMAP -0.15 0.00318 NA
66 hsa-miR-30a-5p CASP3 0.22 0.93395 -0.16 0.90316 miRNATAP -0.2 6.0E-5 NA
67 hsa-miR-143-3p CASP8 0.37 0.92734 -0.27 0.82859 MirTarget -0.11 0.00055 NA
68 hsa-miR-130b-3p CFLAR -0.22 0.82466 -0.06 0.9614 mirMAP -0.17 0 NA
69 hsa-miR-374b-5p CFLAR -0.29 0.8357 -0.06 0.9614 MirTarget -0.16 0.00035 NA
70 hsa-miR-421 CFLAR -0.18 0.7347 -0.06 0.9614 miRanda -0.11 0.00016 NA
71 hsa-miR-23b-3p CHUK -0.11 0.96135 -0.1 0.93218 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.14 0.00997 NA
72 hsa-miR-15b-3p CSF2RB -0.56 0.60918 -0.42 0.60801 mirMAP -0.56 0 NA
73 hsa-miR-186-5p CSF2RB -0.32 0.85413 -0.42 0.60801 mirMAP -0.53 0.00037 NA
74 hsa-miR-19a-3p CSF2RB -0.21 0.84464 -0.42 0.60801 MirTarget -0.51 0 NA
75 hsa-miR-19b-3p CSF2RB -0.03 0.98666 -0.42 0.60801 MirTarget -0.67 0 NA
76 hsa-miR-30b-3p CSF2RB -0.51 0.16242 -0.42 0.60801 MirTarget -0.43 2.0E-5 NA
77 hsa-miR-452-3p CSF2RB -0.17 0.79901 -0.42 0.60801 mirMAP -0.43 0 NA
78 hsa-miR-532-5p CSF2RB -0.35 0.87895 -0.42 0.60801 MirTarget -0.37 0.00041 NA
79 hsa-miR-576-5p CSF2RB -0.51 0.41719 -0.42 0.60801 miRNATAP -0.36 0.0007 NA
80 hsa-miR-590-3p CSF2RB -0.28 0.59127 -0.42 0.60801 miRanda; mirMAP -0.39 1.0E-5 NA
81 hsa-miR-625-5p CSF2RB -0.69 0.21031 -0.42 0.60801 MirTarget -0.29 0.00017 NA
82 hsa-miR-139-5p CYCS -0.08 0.92869 -0.08 0.96574 miRanda -0.18 7.0E-5 NA
83 hsa-miR-34c-3p CYCS -0.07 0.82545 -0.08 0.96574 mirMAP -0.1 0.008 NA
84 hsa-miR-34c-5p CYCS -0.02 0.95279 -0.08 0.96574 miRanda -0.16 0.00033 NA
85 hsa-miR-26a-5p DFFA 0.01 0.99772 -0.29 0.79395 mirMAP -0.17 0.00684 NA
86 hsa-miR-30a-3p DFFA 0.25 0.91709 -0.29 0.79395 mirMAP -0.15 0.00034 NA
87 hsa-miR-34c-5p DFFA -0.02 0.95279 -0.29 0.79395 miRanda -0.11 0.00077 NA
88 hsa-miR-664a-3p DFFA -0 0.99612 -0.29 0.79395 mirMAP -0.14 0.00043 NA
89 hsa-miR-19a-3p ENDOD1 -0.21 0.84464 0.04 0.97377 mirMAP -0.12 0.00066 NA
90 hsa-miR-19b-3p ENDOD1 -0.03 0.98666 0.04 0.97377 mirMAP -0.17 0.00013 NA
91 hsa-miR-20a-3p ENDOD1 0.46 0.57674 0.04 0.97377 MirTarget -0.1 0.00063 NA
92 hsa-miR-335-3p ENDOD1 -0.24 0.8845 0.04 0.97377 MirTarget -0.11 0.00518 NA
93 hsa-miR-450b-5p ENDOD1 -0.01 0.98315 0.04 0.97377 MirTarget; mirMAP -0.12 0.00808 NA
94 hsa-miR-454-3p ENDOD1 -0.1 0.84355 0.04 0.97377 MirTarget -0.15 0.00321 NA
95 hsa-miR-106a-5p FAS -0.2 0.80221 -0.35 0.70281 miRNAWalker2 validate; miRTarBase -0.31 0 22431000; 27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway
96 hsa-miR-361-5p FAS -0.14 0.9415 -0.35 0.70281 miRanda -0.42 0.00016 NA
97 hsa-miR-590-5p FAS -0.55 0.47274 -0.35 0.70281 miRanda -0.17 0.00403 NA
98 hsa-miR-98-5p FAS -0.17 0.8988 -0.35 0.70281 miRNAWalker2 validate -0.38 2.0E-5 NA
99 hsa-miR-452-3p FASLG -0.17 0.79901 -1.02 0.04975 mirMAP -0.3 0.00051 NA
100 hsa-miR-92a-3p FASLG 0.03 0.99325 -1.02 0.04975 miRNATAP -0.38 0.00279 NA
101 hsa-miR-130b-5p IL1R1 -0.65 0.3791 0.1 0.93138 mirMAP -0.6 0 NA
102 hsa-miR-17-3p IL1R1 0.1 0.96011 0.1 0.93138 mirMAP -0.55 0 NA
103 hsa-miR-186-5p IL1R1 -0.32 0.85413 0.1 0.93138 mirMAP -0.76 0 NA
104 hsa-miR-192-5p IL1R1 -0.12 0.97293 0.1 0.93138 miRNAWalker2 validate -0.52 0 NA
105 hsa-miR-197-3p IL1R1 -0.46 0.79492 0.1 0.93138 miRNAWalker2 validate -0.45 0 NA
106 hsa-miR-215-5p IL1R1 -0.14 0.94481 0.1 0.93138 miRNAWalker2 validate -0.13 0.00191 NA
107 hsa-miR-24-3p IL1R1 -0.05 0.98527 0.1 0.93138 miRNATAP -0.6 0.0002 NA
108 hsa-miR-26b-5p IL1R1 -0.02 0.99038 0.1 0.93138 mirMAP -0.73 0 NA
109 hsa-miR-30d-3p IL1R1 -0.12 0.81491 0.1 0.93138 mirMAP -0.63 0 NA
110 hsa-miR-335-3p IL1R1 -0.24 0.8845 0.1 0.93138 mirMAP -0.54 0 NA
111 hsa-miR-361-5p IL1R1 -0.14 0.9415 0.1 0.93138 miRanda -0.66 0 NA
112 hsa-miR-491-5p IL1R1 -0.59 0.04526 0.1 0.93138 miRanda -0.22 0.00269 NA
113 hsa-miR-548o-3p IL1R1 -0.19 0.51773 0.1 0.93138 mirMAP -0.32 2.0E-5 NA
114 hsa-miR-590-3p IL1R1 -0.28 0.59127 0.1 0.93138 miRanda; miRNATAP -0.49 0 NA
115 hsa-let-7f-2-3p IL1RAP -0.05 0.88212 0.16 0.83155 MirTarget -0.14 0.00022 NA
116 hsa-miR-106a-5p IL1RAP -0.2 0.80221 0.16 0.83155 MirTarget -0.19 2.0E-5 NA
117 hsa-miR-106b-5p IL1RAP -0.3 0.86929 0.16 0.83155 MirTarget -0.23 1.0E-5 NA
118 hsa-miR-130a-3p IL1RAP 0.09 0.9291 0.16 0.83155 MirTarget -0.18 0.0001 NA
119 hsa-miR-130b-3p IL1RAP -0.22 0.82466 0.16 0.83155 MirTarget -0.22 0 NA
120 hsa-miR-140-5p IL1RAP -0.23 0.84733 0.16 0.83155 miRanda -0.22 0.00096 NA
121 hsa-miR-17-5p IL1RAP -0.18 0.93454 0.16 0.83155 MirTarget; TargetScan -0.17 2.0E-5 NA
122 hsa-miR-186-5p IL1RAP -0.32 0.85413 0.16 0.83155 mirMAP -0.22 0.00072 NA
123 hsa-miR-192-5p IL1RAP -0.12 0.97293 0.16 0.83155 miRNAWalker2 validate -0.13 0.00026 NA
124 hsa-miR-19a-3p IL1RAP -0.21 0.84464 0.16 0.83155 MirTarget -0.17 1.0E-5 NA
125 hsa-miR-19b-3p IL1RAP -0.03 0.98666 0.16 0.83155 MirTarget -0.17 0.00017 NA
126 hsa-miR-20a-5p IL1RAP -0.18 0.92812 0.16 0.83155 MirTarget -0.14 0.00055 NA
127 hsa-miR-224-3p IL1RAP 0.11 0.74909 0.16 0.83155 MirTarget -0.11 0.00206 NA
128 hsa-miR-29a-3p IL1RAP 0.01 0.99698 0.16 0.83155 MirTarget; miRNATAP -0.19 0.00147 NA
129 hsa-miR-29b-3p IL1RAP -0.1 0.95899 0.16 0.83155 MirTarget; miRNATAP -0.21 0 NA
130 hsa-miR-301a-3p IL1RAP -0.11 0.83169 0.16 0.83155 MirTarget -0.11 0.00516 NA
131 hsa-miR-335-3p IL1RAP -0.24 0.8845 0.16 0.83155 mirMAP -0.13 0.00222 NA
132 hsa-miR-339-5p IL1RAP -0.3 0.71291 0.16 0.83155 miRanda -0.16 2.0E-5 NA
133 hsa-miR-362-3p IL1RAP -0.72 0.03459 0.16 0.83155 miRanda -0.12 0.00094 NA
134 hsa-miR-421 IL1RAP -0.18 0.7347 0.16 0.83155 MirTarget; miRanda -0.14 0.00093 NA
135 hsa-miR-454-3p IL1RAP -0.1 0.84355 0.16 0.83155 MirTarget -0.17 0.00132 NA
136 hsa-miR-576-5p IL1RAP -0.51 0.41719 0.16 0.83155 mirMAP -0.17 0.00017 NA
137 hsa-miR-590-3p IL1RAP -0.28 0.59127 0.16 0.83155 MirTarget; miRanda; mirMAP -0.14 0.00029 NA
138 hsa-miR-590-5p IL1RAP -0.55 0.47274 0.16 0.83155 miRanda -0.21 0 NA
139 hsa-miR-7-1-3p IL1RAP -0.46 0.6659 0.16 0.83155 MirTarget -0.12 0.00722 NA
140 hsa-miR-93-5p IL1RAP -0.61 0.8253 0.16 0.83155 MirTarget -0.15 0.00263 NA
141 hsa-miR-95-3p IL1RAP -0.08 0.92405 0.16 0.83155 MirTarget -0.11 0.00158 NA
142 hsa-miR-362-3p IL3RA -0.72 0.03459 0.16 0.80476 miRanda -0.17 0.0019 NA
143 hsa-miR-330-5p IRAK1 -0.28 0.81569 0.08 0.96334 miRNAWalker2 validate -0.2 0.00014 NA
144 hsa-miR-141-3p IRAK3 -0.32 0.87774 0.13 0.83349 mirMAP -0.47 0 NA
145 hsa-miR-148b-5p IRAK3 -0.24 0.43926 0.13 0.83349 mirMAP -0.26 0.00135 NA
146 hsa-miR-16-1-3p IRAK3 0.15 0.73374 0.13 0.83349 mirMAP -0.26 0.00109 NA
147 hsa-miR-16-2-3p IRAK3 -0.37 0.54685 0.13 0.83349 mirMAP -0.37 1.0E-5 NA
148 hsa-miR-16-5p IRAK3 0.01 0.99448 0.13 0.83349 miRNAWalker2 validate -0.4 9.0E-5 NA
149 hsa-miR-186-5p IRAK3 -0.32 0.85413 0.13 0.83349 mirMAP -0.41 0.0011 NA
150 hsa-miR-188-5p IRAK3 -0.57 0.32482 0.13 0.83349 mirMAP -0.35 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 32 1848 1.174e-22 5.464e-19
2 POSITIVE REGULATION OF RESPONSE TO STIMULUS 32 1929 4.393e-22 6.814e-19
3 INTRACELLULAR SIGNAL TRANSDUCTION 30 1572 4.13e-22 6.814e-19
4 RESPONSE TO OXYGEN CONTAINING COMPOUND 28 1381 4.683e-21 5.448e-18
5 RESPONSE TO NITROGEN COMPOUND 22 859 3.466e-18 3.225e-15
6 REGULATION OF CELL DEATH 26 1472 7.754e-18 6.013e-15
7 RESPONSE TO CYTOKINE 20 714 3.437e-17 2.284e-14
8 IMMUNE SYSTEM PROCESS 28 1984 7.109e-17 3.675e-14
9 POSITIVE REGULATION OF MOLECULAR FUNCTION 27 1791 6.996e-17 3.675e-14
10 CELL DEATH 22 1001 8.736e-17 3.695e-14
11 APOPTOTIC SIGNALING PATHWAY 15 289 8.63e-17 3.695e-14
12 EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 9 39 1.948e-16 7.552e-14
13 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 11 99 3.709e-16 1.328e-13
14 RESPONSE TO ENDOGENOUS STIMULUS 24 1450 1.175e-15 3.904e-13
15 NEGATIVE REGULATION OF CELL DEATH 20 872 1.593e-15 4.942e-13
16 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 25 1656 1.858e-15 5.402e-13
17 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 24 1492 2.23e-15 6.104e-13
18 POSITIVE REGULATION OF CELL COMMUNICATION 24 1532 4.032e-15 1.042e-12
19 REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 13 233 5.157e-15 1.263e-12
20 REGULATION OF IMMUNE SYSTEM PROCESS 23 1403 7.579e-15 1.679e-12
21 POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 12 179 7.245e-15 1.679e-12
22 REGULATION OF IMMUNE RESPONSE 19 858 1.914e-14 4.049e-12
23 POSITIVE REGULATION OF CATALYTIC ACTIVITY 23 1518 4.083e-14 8.26e-12
24 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 12 213 5.874e-14 1.139e-11
25 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 18 799 8.548e-14 1.591e-11
26 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 18 876 4.081e-13 7.304e-11
27 ACTIVATION OF IMMUNE RESPONSE 14 427 5.952e-13 1.026e-10
28 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 9 95 9.81e-13 1.586e-10
29 PHOSPHORYLATION 20 1228 9.885e-13 1.586e-10
30 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 24 1977 1.119e-12 1.736e-10
31 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 9 98 1.307e-12 1.962e-10
32 POSITIVE REGULATION OF IMMUNE RESPONSE 15 563 1.504e-12 2.186e-10
33 POSITIVE REGULATION OF CELL DEATH 15 605 4.203e-12 5.888e-10
34 CELLULAR RESPONSE TO CYTOKINE STIMULUS 15 606 4.303e-12 5.888e-10
35 ZYMOGEN ACTIVATION 9 112 4.455e-12 5.923e-10
36 CELLULAR RESPONSE TO NITROGEN COMPOUND 14 505 5.703e-12 7.372e-10
37 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 10 171 6.314e-12 7.94e-10
38 REGULATION OF KINASE ACTIVITY 16 776 1.105e-11 1.353e-09
39 PROTEIN PHOSPHORYLATION 17 944 1.787e-11 2.132e-09
40 REGULATION OF TRANSFERASE ACTIVITY 17 946 1.848e-11 2.149e-09
41 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 7 49 1.978e-11 2.245e-09
42 TOLL LIKE RECEPTOR SIGNALING PATHWAY 8 85 2.088e-11 2.313e-09
43 CYTOKINE MEDIATED SIGNALING PATHWAY 13 452 2.364e-11 2.559e-09
44 REGULATION OF APOPTOTIC SIGNALING PATHWAY 12 363 3.148e-11 3.329e-09
45 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 5 13 7.304e-11 7.552e-09
46 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 9 153 7.528e-11 7.578e-09
47 REGULATION OF PEPTIDASE ACTIVITY 12 392 7.655e-11 7.578e-09
48 POSITIVE REGULATION OF PEPTIDASE ACTIVITY 9 154 7.982e-11 7.737e-09
49 PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 8 109 1.581e-10 1.458e-08
50 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 6 34 1.548e-10 1.458e-08
51 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 11 321 1.598e-10 1.458e-08
52 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 11 323 1.707e-10 1.527e-08
53 NEURON APOPTOTIC PROCESS 6 35 1.865e-10 1.637e-08
54 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 17 1135 3.163e-10 2.726e-08
55 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 8 120 3.43e-10 2.847e-08
56 POSITIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 5 17 3.487e-10 2.847e-08
57 ACTIVATION OF PROTEIN KINASE A ACTIVITY 5 17 3.487e-10 2.847e-08
58 HOMEOSTATIC PROCESS 18 1337 4.503e-10 3.612e-08
59 PROTEIN MATURATION 10 265 4.736e-10 3.735e-08
60 REGULATION OF PROTEOLYSIS 14 711 5.223e-10 4.051e-08
61 POSITIVE REGULATION OF DEFENSE RESPONSE 11 364 6.051e-10 4.616e-08
62 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 15 867 6.524e-10 4.896e-08
63 CHEMICAL HOMEOSTASIS 15 874 7.287e-10 5.382e-08
64 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 9 200 8.193e-10 5.957e-08
65 ACTIVATION OF INNATE IMMUNE RESPONSE 9 204 9.76e-10 6.987e-08
66 NEURON DEATH 6 47 1.208e-09 8.514e-08
67 REGULATION OF PHOSPHORUS METABOLIC PROCESS 19 1618 1.239e-09 8.601e-08
68 FC EPSILON RECEPTOR SIGNALING PATHWAY 8 142 1.318e-09 9.018e-08
69 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 5 22 1.471e-09 9.92e-08
70 RESPONSE TO PEPTIDE 11 404 1.809e-09 1.203e-07
71 POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 6 51 2.011e-09 1.306e-07
72 REGULATION OF RESPONSE TO STRESS 18 1468 2.02e-09 1.306e-07
73 INTRINSIC APOPTOTIC SIGNALING PATHWAY 8 152 2.263e-09 1.442e-07
74 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 7 95 2.348e-09 1.476e-07
75 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 25 2.952e-09 1.832e-07
76 REGULATION OF PROTEIN MODIFICATION PROCESS 19 1710 3.122e-09 1.898e-07
77 RESPONSE TO TUMOR NECROSIS FACTOR 9 233 3.141e-09 1.898e-07
78 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 6 55 3.215e-09 1.918e-07
79 RENAL SYSTEM PROCESS 7 102 3.875e-09 2.283e-07
80 RESPONSE TO WOUNDING 12 563 4.688e-09 2.727e-07
81 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 9 246 5.049e-09 2.897e-07
82 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 15 1008 5.105e-09 2.897e-07
83 RESPONSE TO ABIOTIC STIMULUS 15 1024 6.316e-09 3.54e-07
84 REGULATION OF INNATE IMMUNE RESPONSE 10 357 8.339e-09 4.619e-07
85 WOUND HEALING 11 470 8.725e-09 4.667e-07
86 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 11 470 8.725e-09 4.667e-07
87 POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 4 11 8.726e-09 4.667e-07
88 RESPONSE TO BIOTIC STIMULUS 14 886 8.831e-09 4.67e-07
89 RESPONSE TO HORMONE 14 893 9.758e-09 5.102e-07
90 POSITIVE REGULATION OF KINASE ACTIVITY 11 482 1.132e-08 5.851e-07
91 CELLULAR RESPONSE TO PEPTIDE 9 274 1.289e-08 6.59e-07
92 REGULATION OF DEFENSE RESPONSE 13 759 1.304e-08 6.594e-07
93 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 8 193 1.482e-08 7.414e-07
94 RENAL WATER HOMEOSTASIS 5 34 1.522e-08 7.455e-07
95 ACTIVATION OF PROTEIN KINASE ACTIVITY 9 279 1.507e-08 7.455e-07
96 CELLULAR GLUCOSE HOMEOSTASIS 6 75 2.156e-08 1.045e-06
97 LEUKOCYTE DIFFERENTIATION 9 292 2.234e-08 1.071e-06
98 FC RECEPTOR SIGNALING PATHWAY 8 206 2.463e-08 1.17e-06
99 REGULATION OF CAMP DEPENDENT PROTEIN KINASE ACTIVITY 4 14 2.633e-08 1.238e-06
100 CELLULAR RESPONSE TO GLUCAGON STIMULUS 5 38 2.726e-08 1.269e-06
101 RESPONSE TO BACTERIUM 11 528 2.884e-08 1.329e-06
102 GLYCEROLIPID BIOSYNTHETIC PROCESS 8 211 2.968e-08 1.354e-06
103 HEMOSTASIS 9 311 3.841e-08 1.735e-06
104 REGULATION OF RESPONSE TO CYTOKINE STIMULUS 7 144 4.283e-08 1.916e-06
105 REGULATION OF CELLULAR PROTEIN LOCALIZATION 11 552 4.537e-08 2.011e-06
106 CELL ACTIVATION 11 568 6.065e-08 2.662e-06
107 REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS 4 17 6.229e-08 2.688e-06
108 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 14 1036 6.298e-08 2.688e-06
109 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 14 1036 6.298e-08 2.688e-06
110 PHOSPHOLIPID BIOSYNTHETIC PROCESS 8 235 6.833e-08 2.89e-06
111 LYMPHOCYTE ACTIVATION 9 342 8.655e-08 3.628e-06
112 RESPONSE TO GLUCAGON 5 48 9.14e-08 3.797e-06
113 NEGATIVE REGULATION OF MOLECULAR FUNCTION 14 1079 1.042e-07 4.291e-06
114 REGULATION OF TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 5 50 1.127e-07 4.6e-06
115 LIPID PHOSPHORYLATION 6 99 1.15e-07 4.653e-06
116 LEUKOCYTE CELL CELL ADHESION 8 255 1.281e-07 5.137e-06
117 IMMUNE RESPONSE 14 1100 1.322e-07 5.257e-06
118 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 9 360 1.338e-07 5.277e-06
119 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 11 616 1.376e-07 5.38e-06
120 POSITIVE REGULATION OF PROTEOLYSIS 9 363 1.436e-07 5.532e-06
121 REGULATION OF CELL PROLIFERATION 16 1496 1.438e-07 5.532e-06
122 NECROPTOTIC PROCESS 4 21 1.556e-07 5.885e-06
123 POSITIVE REGULATION OF PROTEIN IMPORT 6 104 1.544e-07 5.885e-06
124 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 9 370 1.688e-07 6.334e-06
125 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 9 372 1.767e-07 6.576e-06
126 EXECUTION PHASE OF APOPTOSIS 5 55 1.834e-07 6.773e-06
127 REGULATION OF HYDROLASE ACTIVITY 15 1327 1.958e-07 7.174e-06
128 REGULATION OF PROTEIN IMPORT 7 183 2.21e-07 8.035e-06
129 MULTICELLULAR ORGANISMAL WATER HOMEOSTASIS 5 58 2.403e-07 8.602e-06
130 RESPONSE TO AMINO ACID 6 112 2.4e-07 8.602e-06
131 CELLULAR RESPONSE TO STRESS 16 1565 2.667e-07 9.474e-06
132 REGULATION OF ORGANELLE ORGANIZATION 14 1178 3.058e-07 1.078e-05
133 TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 6 118 3.271e-07 1.144e-05
134 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 7 195 3.4e-07 1.181e-05
135 NEGATIVE REGULATION OF CELL COMMUNICATION 14 1192 3.531e-07 1.217e-05
136 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 6 121 3.795e-07 1.298e-05
137 REGULATION OF NECROTIC CELL DEATH 4 26 3.852e-07 1.308e-05
138 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 11 684 3.916e-07 1.32e-05
139 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 8 297 4.094e-07 1.37e-05
140 LEUKOCYTE ACTIVATION 9 414 4.345e-07 1.444e-05
141 INOSITOL LIPID MEDIATED SIGNALING 6 124 4.386e-07 1.447e-05
142 NEGATIVE REGULATION OF CATABOLIC PROCESS 7 203 4.462e-07 1.462e-05
143 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 126 4.82e-07 1.568e-05
144 CELLULAR RESPONSE TO HORMONE STIMULUS 10 552 4.885e-07 1.578e-05
145 NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR SIGNALING PATHWAY 4 28 5.258e-07 1.676e-05
146 NECROTIC CELL DEATH 4 28 5.258e-07 1.676e-05
147 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 6 129 5.538e-07 1.753e-05
148 RESPONSE TO OXYGEN LEVELS 8 311 5.8e-07 1.824e-05
149 REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 29 6.089e-07 1.889e-05
150 POSITIVE REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 29 6.089e-07 1.889e-05
151 WATER HOMEOSTASIS 5 70 6.216e-07 1.903e-05
152 REGULATION OF MEMBRANE PERMEABILITY 5 70 6.216e-07 1.903e-05
153 POSITIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 6 132 6.341e-07 1.928e-05
154 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 5 71 6.675e-07 2.017e-05
155 RESPONSE TO LIPID 12 888 6.767e-07 2.031e-05
156 MYD88 INDEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 4 30 7.013e-07 2.092e-05
157 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 7 218 7.21e-07 2.137e-05
158 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 7 220 7.666e-07 2.258e-05
159 IMMUNE SYSTEM DEVELOPMENT 10 582 7.911e-07 2.315e-05
160 POSITIVE REGULATION OF HYDROLASE ACTIVITY 12 905 8.27e-07 2.405e-05
161 RESPONSE TO ORGANIC CYCLIC COMPOUND 12 917 9.503e-07 2.746e-05
162 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 7 228 9.739e-07 2.797e-05
163 SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 4 33 1.042e-06 2.938e-05
164 EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 4 33 1.042e-06 2.938e-05
165 CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 4 33 1.042e-06 2.938e-05
166 T CELL RECEPTOR SIGNALING PATHWAY 6 146 1.145e-06 3.211e-05
167 T CELL HOMEOSTASIS 4 34 1.179e-06 3.284e-05
168 REGULATION OF INTRACELLULAR TRANSPORT 10 621 1.422e-06 3.939e-05
169 NIK NF KAPPAB SIGNALING 5 83 1.458e-06 4.013e-05
170 POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 36 1.492e-06 4.084e-05
171 GLYCEROLIPID METABOLIC PROCESS 8 356 1.599e-06 4.351e-05
172 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 14 1360 1.719e-06 4.651e-05
173 PHOSPHOLIPID METABOLIC PROCESS 8 364 1.887e-06 5.075e-05
174 REGULATION OF NECROPTOTIC PROCESS 3 11 1.981e-06 5.296e-05
175 RESPONSE TO EXTERNAL STIMULUS 16 1821 2.038e-06 5.417e-05
176 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 4 40 2.299e-06 6.009e-05
177 REGULATION OF BODY FLUID LEVELS 9 506 2.291e-06 6.009e-05
178 LEUKOCYTE MIGRATION 7 259 2.277e-06 6.009e-05
179 MITOCHONDRIAL MEMBRANE ORGANIZATION 5 92 2.43e-06 6.317e-05
180 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 11 829 2.575e-06 6.657e-05
181 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 9 514 2.605e-06 6.698e-05
182 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 3 12 2.636e-06 6.74e-05
183 PROTEOLYSIS 13 1208 2.728e-06 6.936e-05
184 GLUCOSE HOMEOSTASIS 6 170 2.777e-06 6.986e-05
185 CARBOHYDRATE HOMEOSTASIS 6 170 2.777e-06 6.986e-05
186 REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 43 3.088e-06 7.685e-05
187 CELLULAR COMPONENT DISASSEMBLY INVOLVED IN EXECUTION PHASE OF APOPTOSIS 4 43 3.088e-06 7.685e-05
188 MULTICELLULAR ORGANISMAL HOMEOSTASIS 7 272 3.147e-06 7.79e-05
189 HEPATOCYTE APOPTOTIC PROCESS 3 13 3.422e-06 8.336e-05
190 INTERLEUKIN 1 MEDIATED SIGNALING PATHWAY 3 13 3.422e-06 8.336e-05
191 RESPONSE TO COBALT ION 3 13 3.422e-06 8.336e-05
192 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 4 46 4.063e-06 9.846e-05
193 REGULATION OF LIPID KINASE ACTIVITY 4 48 4.828e-06 0.0001164
194 PROTEIN DEPHOSPHORYLATION 6 190 5.276e-06 0.0001265
195 T CELL APOPTOTIC PROCESS 3 15 5.426e-06 0.0001295
196 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 12 1087 5.564e-06 0.0001321
197 REGULATION OF NEURON APOPTOTIC PROCESS 6 192 5.603e-06 0.0001323
198 LYMPHOCYTE HOMEOSTASIS 4 50 5.694e-06 0.0001338
199 CELLULAR CHEMICAL HOMEOSTASIS 9 570 6.037e-06 0.0001412
200 REGULATION OF CATABOLIC PROCESS 10 731 6.081e-06 0.0001415
201 REGULATION OF PROTEIN TARGETING 7 307 6.967e-06 0.0001613
202 CELLULAR RESPONSE TO AMINO ACID STIMULUS 4 53 7.203e-06 0.0001659
203 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 3 17 8.082e-06 0.0001843
204 NEGATIVE REGULATION OF ANOIKIS 3 17 8.082e-06 0.0001843
205 POSITIVE REGULATION OF TRANSPORT 11 936 8.223e-06 0.0001866
206 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 8 450 8.988e-06 0.000203
207 LYMPHOCYTE DIFFERENTIATION 6 209 9.105e-06 0.0002047
208 LIPID MODIFICATION 6 210 9.357e-06 0.0002093
209 REGULATION OF PROTEIN LOCALIZATION 11 950 9.462e-06 0.0002107
210 INFLAMMATORY RESPONSE 8 454 9.586e-06 0.0002124
211 INOSITOL PHOSPHATE MEDIATED SIGNALING 3 18 9.682e-06 0.0002125
212 LYMPHOCYTE APOPTOTIC PROCESS 3 18 9.682e-06 0.0002125
213 SINGLE ORGANISM CELL ADHESION 8 459 1.038e-05 0.0002267
214 REGULATION OF MITOCHONDRION ORGANIZATION 6 218 1.158e-05 0.0002517
215 REGULATION OF GLUCOSE IMPORT 4 60 1.185e-05 0.0002553
216 LEUKOCYTE HOMEOSTASIS 4 60 1.185e-05 0.0002553
217 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 4 61 1.266e-05 0.0002715
218 B CELL ACTIVATION 5 132 1.425e-05 0.0003042
219 REGULATION OF CYTOPLASMIC TRANSPORT 8 481 1.456e-05 0.0003095
220 IMMUNE EFFECTOR PROCESS 8 486 1.569e-05 0.0003319
221 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 3 23 2.084e-05 0.0004368
222 LEUKOCYTE APOPTOTIC PROCESS 3 23 2.084e-05 0.0004368
223 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 7 365 2.136e-05 0.0004457
224 I KAPPAB KINASE NF KAPPAB SIGNALING 4 70 2.191e-05 0.000455
225 CELLULAR HOMEOSTASIS 9 676 2.354e-05 0.0004867
226 REGULATION OF ANOIKIS 3 24 2.378e-05 0.0004874
227 REGULATION OF EXECUTION PHASE OF APOPTOSIS 3 24 2.378e-05 0.0004874
228 NEGATIVE REGULATION OF KINASE ACTIVITY 6 250 2.511e-05 0.0005125
229 REGULATION OF NEURON DEATH 6 252 2.626e-05 0.0005336
230 CELLULAR EXTRAVASATION 3 25 2.698e-05 0.0005434
231 EPITHELIAL CELL APOPTOTIC PROCESS 3 25 2.698e-05 0.0005434
232 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 4 74 2.73e-05 0.0005475
233 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 7 381 2.811e-05 0.0005613
234 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 6 258 2.997e-05 0.0005959
235 NEGATIVE REGULATION OF CELLULAR CATABOLIC PROCESS 5 156 3.188e-05 0.0006313
236 LIPID BIOSYNTHETIC PROCESS 8 539 3.292e-05 0.000649
237 CELLULAR RESPONSE TO ABIOTIC STIMULUS 6 263 3.337e-05 0.0006551
238 INSULIN RECEPTOR SIGNALING PATHWAY 4 80 3.714e-05 0.0007261
239 REGULATION OF PROTEIN MATURATION 4 82 4.093e-05 0.0007969
240 POSITIVE REGULATION OF NIK NF KAPPAB SIGNALING 3 29 4.258e-05 0.0008255
241 POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION 5 167 4.416e-05 0.0008526
242 RESPONSE TO CARBOHYDRATE 5 168 4.544e-05 0.0008736
243 NEGATIVE REGULATION OF B CELL ACTIVATION 3 30 4.723e-05 0.0009044
244 NEGATIVE REGULATION OF PROTEIN COMPLEX DISASSEMBLY 5 170 4.807e-05 0.0009167
245 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 6 282 4.923e-05 0.0009312
246 REGULATION OF LIPID METABOLIC PROCESS 6 282 4.923e-05 0.0009312
247 STRIATED MUSCLE CELL DIFFERENTIATION 5 173 5.225e-05 0.0009802
248 LIPOPOLYSACCHARIDE MEDIATED SIGNALING PATHWAY 3 31 5.22e-05 0.0009802
249 DEPHOSPHORYLATION 6 286 5.324e-05 0.0009949
250 CELLULAR RESPONSE TO INTERLEUKIN 1 4 88 5.401e-05 0.001001
251 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 4 88 5.401e-05 0.001001
252 MYD88 DEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 3 32 5.751e-05 0.001049
253 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 3 32 5.751e-05 0.001049
254 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 3 32 5.751e-05 0.001049
255 NEGATIVE REGULATION OF SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 3 32 5.751e-05 0.001049
256 MITOCHONDRIAL TRANSPORT 5 177 5.824e-05 0.001059
257 RESPONSE TO DRUG 7 431 6.141e-05 0.001112
258 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 10 957 6.177e-05 0.001114
259 REGULATION OF INFLAMMATORY RESPONSE 6 294 6.203e-05 0.001114
260 MITOCHONDRION ORGANIZATION 8 594 6.534e-05 0.001169
261 REGULATION OF MYELOID CELL DIFFERENTIATION 5 183 6.821e-05 0.001216
262 NEGATIVE REGULATION OF PROTEIN PROCESSING 3 35 7.551e-05 0.001336
263 NEGATIVE REGULATION OF PROTEIN MATURATION 3 35 7.551e-05 0.001336
264 MYELOID LEUKOCYTE DIFFERENTIATION 4 96 7.59e-05 0.001338
265 CELL CELL ADHESION 8 608 7.689e-05 0.00135
266 MYELOID CELL DIFFERENTIATION 5 189 7.946e-05 0.00139
267 RESPONSE TO REACTIVE OXYGEN SPECIES 5 191 8.351e-05 0.001455
268 REGULATION OF GLUCOSE TRANSPORT 4 100 8.898e-05 0.001545
269 RESPONSE TO ACID CHEMICAL 6 319 9.726e-05 0.001682
270 STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 4 103 9.981e-05 0.00172
271 DEFENSE RESPONSE 11 1231 0.0001025 0.00176
272 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 3 39 0.0001047 0.001792
273 MITOTIC SPINDLE ASSEMBLY 3 41 0.0001218 0.002068
274 MICROTUBULE CYTOSKELETON ORGANIZATION INVOLVED IN MITOSIS 3 41 0.0001218 0.002068
275 REGULATION OF CELL ACTIVATION 7 484 0.0001266 0.002143
276 REGULATION OF NIK NF KAPPAB SIGNALING 3 42 0.0001309 0.002199
277 POSITIVE REGULATION OF GLUCOSE TRANSPORT 3 42 0.0001309 0.002199
278 MYELOID LEUKOCYTE MEDIATED IMMUNITY 3 43 0.0001405 0.002352
279 REGULATION OF CELLULAR LOCALIZATION 11 1277 0.000142 0.002368
280 REGULATION OF PROTEIN COMPLEX DISASSEMBLY 5 217 0.000152 0.002526
281 RESPONSE TO INTERLEUKIN 1 4 115 0.0001529 0.002532
282 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 6 351 0.0001638 0.002703
283 RESPONSE TO OXIDATIVE STRESS 6 352 0.0001664 0.002736
284 SYSTEM PROCESS 13 1785 0.00017 0.002786
285 POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS 3 47 0.0001834 0.002995
286 REGULATION OF B CELL ACTIVATION 4 121 0.0001859 0.003025
287 ORGANOPHOSPHATE METABOLIC PROCESS 9 885 0.0001869 0.003031
288 T CELL DIFFERENTIATION 4 123 0.000198 0.003199
289 EMBRYO DEVELOPMENT 9 894 0.0002016 0.003246
290 REGULATION OF TOLL LIKE RECEPTOR SIGNALING PATHWAY 3 49 0.0002077 0.003333
291 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 5 233 0.0002116 0.003384
292 RESPONSE TO GAMMA RADIATION 3 50 0.0002206 0.003516
293 MUSCLE CELL DIFFERENTIATION 5 237 0.000229 0.003637
294 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION 4 128 0.0002307 0.003651
295 RESPONSE TO NICOTINE 3 51 0.000234 0.003691
296 CELLULAR LIPID METABOLIC PROCESS 9 913 0.0002359 0.003708
297 NUCLEAR IMPORT 4 129 0.0002377 0.003724
298 RESPONSE TO TOXIC SUBSTANCE 5 241 0.0002474 0.003863
299 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 7 541 0.0002508 0.00389
300 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 7 541 0.0002508 0.00389
301 NEGATIVE REGULATION OF ORGANELLE ORGANIZATION 6 387 0.0002774 0.004273
302 RESPONSE TO VIRUS 5 247 0.0002772 0.004273
303 REGULATION OF AUTOPHAGY 5 249 0.0002877 0.004417
304 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 7 554 0.0002897 0.004435
305 REGULATION OF B CELL PROLIFERATION 3 55 0.0002929 0.00446
306 NEGATIVE REGULATION OF NECROTIC CELL DEATH 2 11 0.0002933 0.00446
307 RESPONSE TO ALKALOID 4 137 0.0002991 0.004533
308 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 4 138 0.0003075 0.004645
309 PLATELET ACTIVATION 4 142 0.0003428 0.005162
310 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 6 404 0.000349 0.005238
311 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 7 573 0.0003552 0.005315
312 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 3 59 0.0003605 0.005377
313 RESPONSE TO IONIZING RADIATION 4 145 0.0003711 0.005516
314 AGING 5 264 0.0003763 0.005576
315 ESTABLISHMENT OF LOCALIZATION IN CELL 12 1676 0.0003775 0.005576
316 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 3 60 0.0003789 0.005579
317 CELLULAR RESPONSE TO INSULIN STIMULUS 4 146 0.0003809 0.005591
318 REGULATION OF RESPONSE TO WOUNDING 6 413 0.0003923 0.005723
319 RESPONSE TO RADIATION 6 413 0.0003923 0.005723
320 RESPONSE TO TEMPERATURE STIMULUS 4 148 0.000401 0.005831
321 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 9 983 0.0004068 0.005896
322 REGULATION OF PROTEIN POLYUBIQUITINATION 2 13 0.0004147 0.005993
323 NEGATIVE REGULATION OF PHOSPHORYLATION 6 422 0.0004398 0.006336
324 PROTEIN IMPORT 4 155 0.0004776 0.006859
325 TOLL LIKE RECEPTOR 9 SIGNALING PATHWAY 2 14 0.0004831 0.006874
326 REGULATION OF FIBROBLAST APOPTOTIC PROCESS 2 14 0.0004831 0.006874
327 T CELL MIGRATION 2 14 0.0004831 0.006874
328 PROTEIN LOCALIZATION TO NUCLEUS 4 156 0.0004893 0.006942
329 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 8 801 0.0005024 0.007105
330 NEGATIVE REGULATION OF CELL CYCLE 6 433 0.0005039 0.007105
331 PROTEIN OLIGOMERIZATION 6 434 0.00051 0.00717
332 POSITIVE REGULATION OF GENE EXPRESSION 12 1733 0.000512 0.007174
333 NEGATIVE REGULATION OF CELL ACTIVATION 4 158 0.0005134 0.007174
334 POSITIVE REGULATION OF NEURON DEATH 3 67 0.0005244 0.007305
335 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 6 437 0.0005289 0.007346
336 NEGATIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 3 68 0.0005476 0.007564
337 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 7 616 0.0005478 0.007564
338 RESPIRATORY BURST 2 15 0.0005566 0.007595
339 NEGATIVE REGULATION OF B CELL PROLIFERATION 2 15 0.0005566 0.007595
340 APOPTOTIC DNA FRAGMENTATION 2 15 0.0005566 0.007595
341 REGULATION OF VIRAL INDUCED CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 2 15 0.0005566 0.007595
342 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 5 289 0.0005682 0.00773
343 NEGATIVE REGULATION OF LEUKOCYTE PROLIFERATION 3 69 0.0005716 0.007732
344 MITOTIC SPINDLE ORGANIZATION 3 69 0.0005716 0.007732
345 CELLULAR RESPONSE TO BIOTIC STIMULUS 4 163 0.0005773 0.007786
346 SPINDLE ASSEMBLY 3 70 0.0005962 0.008018
347 REGULATION OF CELL ADHESION 7 629 0.0006201 0.008315
348 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 4 168 0.0006466 0.008645
349 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 3 74 0.0007014 0.009352
350 ACTIVATION OF NF KAPPAB INDUCING KINASE ACTIVITY 2 17 0.0007188 0.009528
351 NEGATIVE REGULATION OF LIPID STORAGE 2 17 0.0007188 0.009528
352 GRANULOCYTE MIGRATION 3 75 0.0007294 0.009642
353 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 6 465 0.0007323 0.009652
354 REGULATION OF TRANSPORT 12 1804 0.0007349 0.009659
355 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 12 1805 0.0007385 0.00968
356 CELLULAR RESPONSE TO ACID CHEMICAL 4 175 0.0007533 0.009818
357 HOMEOSTASIS OF NUMBER OF CELLS 4 175 0.0007533 0.009818
NumGOOverlapSizeP ValueAdj. P Value
1 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 43 7.5e-12 3.484e-09
2 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 8 70 4.204e-12 3.484e-09
3 KINASE REGULATOR ACTIVITY 10 186 1.459e-11 4.517e-09
4 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 7 51 2.657e-11 6.171e-09
5 KINASE ACTIVITY 16 842 3.737e-11 6.943e-09
6 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 16 992 4.19e-10 6.488e-08
7 MOLECULAR FUNCTION REGULATOR 18 1353 5.456e-10 7.242e-08
8 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY BINDING 6 47 1.208e-09 1.402e-07
9 ENZYME REGULATOR ACTIVITY 15 959 2.596e-09 2.68e-07
10 ENZYME BINDING 19 1737 4.05e-09 3.763e-07
11 PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 5 30 7.85e-09 6.63e-07
12 CYTOKINE RECEPTOR BINDING 9 271 1.172e-08 9.07e-07
13 PROTEIN KINASE A CATALYTIC SUBUNIT BINDING 4 15 3.585e-08 2.379e-06
14 CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC PROCESS 4 15 3.585e-08 2.379e-06
15 CYSTEINE TYPE ENDOPEPTIDASE REGULATOR ACTIVITY INVOLVED IN APOPTOTIC PROCESS 5 42 4.588e-08 2.842e-06
16 DEATH RECEPTOR BINDING 4 18 7.994e-08 4.642e-06
17 PROTEASE BINDING 6 104 1.544e-07 8.436e-06
18 UBIQUITIN LIKE PROTEIN LIGASE BINDING 8 264 1.67e-07 8.62e-06
19 PROTEIN KINASE ACTIVITY 11 640 2.019e-07 9.87e-06
20 CAMP BINDING 4 23 2.294e-07 1.065e-05
21 TUMOR NECROSIS FACTOR RECEPTOR BINDING 4 30 7.013e-07 3.103e-05
22 PROTEIN SERINE THREONINE KINASE ACTIVITY 9 445 7.936e-07 3.351e-05
23 ADENYL NUCLEOTIDE BINDING 15 1514 1.061e-06 4.285e-05
24 PROTEIN HETERODIMERIZATION ACTIVITY 9 468 1.205e-06 4.665e-05
25 CYCLIC NUCLEOTIDE BINDING 4 36 1.492e-06 5.544e-05
26 CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 5 86 1.739e-06 6.214e-05
27 KINASE INHIBITOR ACTIVITY 5 89 2.062e-06 7.095e-05
28 ENZYME INHIBITOR ACTIVITY 8 378 2.497e-06 8.285e-05
29 PROTEIN KINASE A BINDING 4 42 2.806e-06 8.989e-05
30 PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY 3 16 6.667e-06 0.0002064
31 RIBONUCLEOTIDE BINDING 15 1860 1.35e-05 0.0004046
32 PROTEIN SERINE THREONINE PHOSPHATASE ACTIVITY 4 64 1.534e-05 0.0004452
33 CYSTEINE TYPE ENDOPEPTIDASE INHIBITOR ACTIVITY INVOLVED IN APOPTOTIC PROCESS 3 23 2.084e-05 0.0005867
34 DEATH RECEPTOR ACTIVITY 3 24 2.378e-05 0.0006497
35 PROTEIN DIMERIZATION ACTIVITY 11 1149 5.51e-05 0.001457
36 CYTOKINE RECEPTOR ACTIVITY 4 89 5.646e-05 0.001457
37 PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 5 178 5.982e-05 0.001502
38 CYSTEINE TYPE PEPTIDASE ACTIVITY 5 184 7e-05 0.001711
39 KINASE BINDING 8 606 7.515e-05 0.00179
40 RECEPTOR BINDING 12 1476 0.000115 0.002671
41 PEPTIDASE REGULATOR ACTIVITY 5 214 0.0001424 0.003227
42 PROTEIN PHOSPHATASE BINDING 4 120 0.0001801 0.003984
43 INSULIN RECEPTOR SUBSTRATE BINDING 2 11 0.0002933 0.006337
44 CYSTEINE TYPE ENDOPEPTIDASE INHIBITOR ACTIVITY 3 56 0.000309 0.006523
45 PHOSPHATASE ACTIVITY 5 275 0.0004534 0.00936
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 13 237 6.431e-15 3.756e-12
2 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 7 20 1.878e-14 5.485e-12
3 CATALYTIC COMPLEX 20 1038 4.309e-14 8.387e-12
4 MEMBRANE MICRODOMAIN 12 288 2.109e-12 3.079e-10
5 MEMBRANE PROTEIN COMPLEX 17 1020 6.021e-11 7.033e-09
6 CILIARY BASE 5 23 1.876e-09 1.826e-07
7 TRANSFERASE COMPLEX 13 703 5.229e-09 4.363e-07
8 PROTEIN KINASE COMPLEX 6 90 6.492e-08 4.739e-06
9 EXTRINSIC COMPONENT OF MEMBRANE 7 252 1.898e-06 0.0001232
10 PLASMA MEMBRANE PROTEIN COMPLEX 9 510 2.444e-06 0.0001427
11 PHOSPHATASE COMPLEX 4 48 4.828e-06 0.0002563
12 MEMBRANE REGION 12 1134 8.565e-06 0.0004168
13 CYTOSOLIC PART 5 223 0.0001726 0.007755
14 SARCOLEMMA 4 125 0.0002107 0.008788

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04210_Apoptosis 47 89 8.812e-118 1.586e-115
2 hsa04650_Natural_killer_cell_mediated_cytotoxicity 18 136 1.166e-27 1.049e-25
3 hsa04662_B_cell_receptor_signaling_pathway 14 75 9.318e-24 5.591e-22
4 hsa04660_T_cell_receptor_signaling_pathway 15 108 2.296e-23 1.033e-21
5 hsa04380_Osteoclast_differentiation 15 128 3.362e-22 1.21e-20
6 hsa04620_Toll.like_receptor_signaling_pathway 14 102 9.478e-22 2.843e-20
7 hsa04722_Neurotrophin_signaling_pathway 14 127 2.375e-20 6.107e-19
8 hsa04370_VEGF_signaling_pathway 12 76 1.715e-19 3.858e-18
9 hsa04910_Insulin_signaling_pathway 13 138 5.196e-18 1.039e-16
10 hsa04510_Focal_adhesion 13 200 7.048e-16 1.269e-14
11 hsa04630_Jak.STAT_signaling_pathway 11 155 5.797e-14 9.486e-13
12 hsa04973_Carbohydrate_digestion_and_absorption 8 44 8.258e-14 1.239e-12
13 hsa04664_Fc_epsilon_RI_signaling_pathway 9 79 1.766e-13 2.445e-12
14 hsa04150_mTOR_signaling_pathway 8 52 3.458e-13 4.446e-12
15 hsa04914_Progesterone.mediated_oocyte_maturation 9 87 4.342e-13 5.21e-12
16 hsa04062_Chemokine_signaling_pathway 11 189 5.188e-13 5.837e-12
17 hsa04010_MAPK_signaling_pathway 12 268 9.028e-13 9.559e-12
18 hsa04151_PI3K_AKT_signaling_pathway 13 351 9.869e-13 9.869e-12
19 hsa04960_Aldosterone.regulated_sodium_reabsorption 7 42 6.29e-12 5.959e-11
20 hsa04012_ErbB_signaling_pathway 8 87 2.526e-11 2.274e-10
21 hsa04666_Fc_gamma_R.mediated_phagocytosis 8 95 5.183e-11 4.442e-10
22 hsa04621_NOD.like_receptor_signaling_pathway 7 59 7.72e-11 6.317e-10
23 hsa04014_Ras_signaling_pathway 10 236 1.528e-10 1.196e-09
24 hsa04115_p53_signaling_pathway 7 69 2.399e-10 1.799e-09
25 hsa04070_Phosphatidylinositol_signaling_system 7 78 5.783e-10 4.164e-09
26 hsa04670_Leukocyte_transendothelial_migration 7 117 1.014e-08 7.018e-08
27 hsa04720_Long.term_potentiation 5 70 6.216e-07 4.093e-06
28 hsa04810_Regulation_of_actin_cytoskeleton 7 214 6.367e-07 4.093e-06
29 hsa04622_RIG.I.like_receptor_signaling_pathway 5 71 6.675e-07 4.143e-06
30 hsa04114_Oocyte_meiosis 5 114 6.981e-06 4.188e-05
31 hsa04920_Adipocytokine_signaling_pathway 4 68 1.952e-05 0.0001134
32 hsa04310_Wnt_signaling_pathway 5 151 2.727e-05 0.0001534
33 hsa04020_Calcium_signaling_pathway 5 177 5.824e-05 0.0003177
34 hsa04360_Axon_guidance 4 130 0.0002448 0.001296
35 hsa00562_Inositol_phosphate_metabolism 3 57 0.0003256 0.001674
36 hsa04640_Hematopoietic_cell_lineage 3 88 0.00116 0.005802
37 hsa04120_Ubiquitin_mediated_proteolysis 3 139 0.00426 0.02073
38 hsa04623_Cytosolic_DNA.sensing_pathway 2 56 0.007678 0.03637
39 hsa04141_Protein_processing_in_endoplasmic_reticulum 2 168 0.05929 0.2736

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

CECR7

hsa-miR-130b-5p;hsa-miR-17-3p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-197-3p;hsa-miR-215-5p;hsa-miR-24-3p;hsa-miR-26b-5p;hsa-miR-335-3p;hsa-miR-361-5p;hsa-miR-491-5p;hsa-miR-590-3p 12 IL1R1 Sponge network 0.551 0.56177 0.097 0.93138 0.556
2

EMX2OS

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-374b-5p;hsa-miR-421;hsa-miR-424-5p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-502-5p;hsa-miR-505-3p;hsa-miR-577;hsa-miR-663b;hsa-miR-93-5p 25 AKT3 Sponge network 1.057 0.31716 0.457 0.53933 0.542
3

EMX2OS

hsa-miR-130b-5p;hsa-miR-17-3p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-197-3p;hsa-miR-215-5p;hsa-miR-26b-5p;hsa-miR-30d-3p;hsa-miR-335-3p;hsa-miR-590-3p 10 IL1R1 Sponge network 1.057 0.31716 0.097 0.93138 0.517
4

CECR7

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1275;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-362-5p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-502-5p;hsa-miR-93-5p 20 AKT3 Sponge network 0.551 0.56177 0.457 0.53933 0.508
5

CECR7

hsa-miR-141-3p;hsa-miR-148b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-200a-3p;hsa-miR-20a-3p;hsa-miR-25-3p;hsa-miR-335-3p;hsa-miR-33a-5p;hsa-miR-33b-5p;hsa-miR-429;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p 18 IRAK3 Sponge network 0.551 0.56177 0.129 0.83349 0.45
6

EMX2OS

hsa-miR-141-3p;hsa-miR-148b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-200a-3p;hsa-miR-20a-3p;hsa-miR-25-3p;hsa-miR-32-5p;hsa-miR-324-5p;hsa-miR-335-3p;hsa-miR-33a-5p;hsa-miR-33b-5p;hsa-miR-374b-5p;hsa-miR-421;hsa-miR-452-3p;hsa-miR-505-3p;hsa-miR-577;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-660-5p;hsa-miR-7-1-3p;hsa-miR-92a-3p 25 IRAK3 Sponge network 1.057 0.31716 0.129 0.83349 0.42
7

MEG3

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-577;hsa-miR-93-5p 12 AKT3 Sponge network 0.433 0.33816 0.457 0.53933 0.405
8

CECR7

hsa-let-7f-1-3p;hsa-miR-148a-5p;hsa-miR-148b-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-32-3p;hsa-miR-335-5p;hsa-miR-582-3p;hsa-miR-590-3p;hsa-miR-590-5p 11 PIK3CA Sponge network 0.551 0.56177 0.023 0.97942 0.368
9

CECR7

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-186-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-335-3p;hsa-miR-361-5p;hsa-miR-362-3p;hsa-miR-429;hsa-miR-590-3p 10 PRKAR2B Sponge network 0.551 0.56177 -0.108 0.86421 0.346
10

ZNF883

hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-33a-3p 10 AKT3 Sponge network 0.913 0.16772 0.457 0.53933 0.3
11

MEG3

hsa-miR-141-3p;hsa-miR-148b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-200a-3p;hsa-miR-20a-3p;hsa-miR-335-3p;hsa-miR-429;hsa-miR-577;hsa-miR-590-5p;hsa-miR-7-1-3p 12 IRAK3 Sponge network 0.433 0.33816 0.129 0.83349 0.279
12

EMX2OS

hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-186-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-32-5p;hsa-miR-335-3p;hsa-miR-362-3p;hsa-miR-452-5p;hsa-miR-590-3p;hsa-miR-92a-3p 11 PRKAR2B Sponge network 1.057 0.31716 -0.108 0.86421 0.278
13

EMX2OS

hsa-let-7f-1-3p;hsa-miR-148a-5p;hsa-miR-148b-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-32-3p;hsa-miR-335-5p;hsa-miR-339-5p;hsa-miR-374b-5p;hsa-miR-576-5p;hsa-miR-582-3p;hsa-miR-590-3p 13 PIK3CA Sponge network 1.057 0.31716 0.023 0.97942 0.254

Quest ID: 50b329c069b3ef065bad3568cb1c0623