Explanation
This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are
presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.
"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.
miRNA-gene regulations
| Num | microRNA | Gene | miRNA log2FC | miRNA pvalue | Gene log2FC | Gene pvalue | Interaction | Correlation beta | Correlation P-value | PMID | Reported in cancer studies |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | hsa-let-7a-5p | AIFM1 | -0.44 | 3.0E-5 | 0.03 | 0.68966 | TargetScan; miRNATAP | -0.1 | 0.00076 | NA | |
| 2 | hsa-let-7b-5p | AIFM1 | -0.25 | 0.02114 | 0.03 | 0.68966 | miRNATAP | -0.16 | 0 | NA | |
| 3 | hsa-miR-139-5p | AKT3 | -1.46 | 0 | 0.76 | 5.0E-5 | PITA; miRanda | -0.2 | 7.0E-5 | NA | |
| 4 | hsa-miR-15a-5p | AKT3 | 0.78 | 0 | 0.76 | 5.0E-5 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.27 | 0.00011 | NA | |
| 5 | hsa-miR-17-5p | AKT3 | 1.42 | 0 | 0.76 | 5.0E-5 | TargetScan; miRNATAP | -0.21 | 1.0E-5 | NA | |
| 6 | hsa-miR-205-3p | AKT3 | 1.3 | 0 | 0.76 | 5.0E-5 | mirMAP | -0.25 | 0 | NA | |
| 7 | hsa-miR-20a-5p | AKT3 | 1.15 | 0 | 0.76 | 5.0E-5 | miRNATAP | -0.24 | 0 | NA | |
| 8 | hsa-miR-29b-3p | AKT3 | -0.11 | 0.51126 | 0.76 | 5.0E-5 | miRNATAP | -0.26 | 0 | 26512921 | MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 |
| 9 | hsa-miR-362-3p | AKT3 | -0.7 | 0 | 0.76 | 5.0E-5 | miRanda | -0.2 | 0.00031 | NA | |
| 10 | hsa-miR-362-5p | AKT3 | 0.41 | 0.04043 | 0.76 | 5.0E-5 | PITA; TargetScan; miRNATAP | -0.16 | 0.00012 | NA | |
| 11 | hsa-miR-664a-3p | APAF1 | -0.26 | 0.05132 | 0.25 | 0.00843 | mirMAP | -0.13 | 3.0E-5 | NA | |
| 12 | hsa-miR-18a-5p | ATM | 1.65 | 0 | -0.09 | 0.45414 | miRNAWalker2 validate; miRTarBase; MirTarget | -0.17 | 0 | 23437304; 25963391; 23857602; 23229340 | MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases |
| 13 | hsa-miR-19b-3p | ATM | 0.54 | 0.00062 | -0.09 | 0.45414 | miRNAWalker2 validate | -0.19 | 0 | NA | |
| 14 | hsa-miR-203a-3p | ATM | 0.04 | 0.88046 | -0.09 | 0.45414 | MirTarget | -0.1 | 0 | 24145123; 27542403 | miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression |
| 15 | hsa-miR-21-5p | ATM | 1.62 | 0 | -0.09 | 0.45414 | mirMAP | -0.14 | 0.00355 | 26289851 | MiR-21 is an oncomiR that is overexpressed in nearly all cancers including ATC; Hence suppression of miR-21 could pave the way for ATC therapy |
| 16 | hsa-miR-30c-5p | ATM | 0.02 | 0.88637 | -0.09 | 0.45414 | mirMAP | -0.12 | 0.00081 | NA | |
| 17 | hsa-miR-339-5p | ATM | 1.08 | 0 | -0.09 | 0.45414 | miRanda | -0.14 | 0 | NA | |
| 18 | hsa-miR-455-5p | ATM | 1.41 | 0 | -0.09 | 0.45414 | miRanda | -0.22 | 0 | NA | |
| 19 | hsa-miR-500a-5p | ATM | 0.68 | 8.0E-5 | -0.09 | 0.45414 | mirMAP | -0.14 | 1.0E-5 | NA | |
| 20 | hsa-miR-576-5p | ATM | 0.94 | 0 | -0.09 | 0.45414 | mirMAP | -0.17 | 2.0E-5 | NA | |
| 21 | hsa-miR-590-5p | ATM | 0.76 | 0 | -0.09 | 0.45414 | mirMAP | -0.15 | 0.00038 | NA | |
| 22 | hsa-miR-127-3p | BAD | -1.47 | 0 | 0.23 | 0.0411 | miRanda; miRNATAP | -0.11 | 1.0E-5 | NA | |
| 23 | hsa-miR-326 | BAD | -0.43 | 0.0415 | 0.23 | 0.0411 | miRanda | -0.16 | 0 | NA | |
| 24 | hsa-miR-17-5p | BCL2 | 1.42 | 0 | -0.91 | 1.0E-5 | miRNAWalker2 validate; miRTarBase | -0.29 | 0 | 25435430 | Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 |
| 25 | hsa-miR-181b-5p | BCL2 | 0.97 | 0 | -0.91 | 1.0E-5 | miRNAWalker2 validate; miRTarBase | -0.37 | 0 | 25524579 | Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression |
| 26 | hsa-miR-205-3p | BCL2 | 1.3 | 0 | -0.91 | 1.0E-5 | mirMAP | -0.23 | 0 | 23612742 | MicroRNA 205 a novel regulator of the anti apoptotic protein Bcl2 is downregulated in prostate cancer; In addition we describe the anti-apoptotic protein BCL2 as a target of miR-205 relevant for prostate cancer due to its role in prognosis of primary tumours and in the appearance of androgen independence; The repression of BCL2 by miR-205 was confirmed using reporter assays and western blotting; Consistent with its anti-apoptotic target BCL2 miR-205 promoted apoptosis in prostate cancer cells in response to DNA damage by cisplatin and doxorubicin in the prostate cancer cell lines PC3 and LnCap |
| 27 | hsa-miR-20a-3p | BCL2 | 1.35 | 0 | -0.91 | 1.0E-5 | mirMAP | -0.21 | 1.0E-5 | NA | |
| 28 | hsa-miR-20a-5p | BCL2 | 1.15 | 0 | -0.91 | 1.0E-5 | miRNAWalker2 validate; miRTarBase | -0.21 | 8.0E-5 | NA | |
| 29 | hsa-miR-21-5p | BCL2 | 1.62 | 0 | -0.91 | 1.0E-5 | miRNAWalker2 validate; miRTarBase | -0.44 | 0 | 21468550; 25994220; 25381586; 26555418; 23359184; 22964582; 21376256 | BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells |
| 30 | hsa-miR-224-3p | BCL2 | 0.5 | 0.00811 | -0.91 | 1.0E-5 | mirMAP | -0.15 | 0.00211 | 24796455 | In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 |
| 31 | hsa-miR-224-5p | BCL2 | 1.95 | 0 | -0.91 | 1.0E-5 | mirMAP | -0.35 | 0 | 24796455 | In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 |
| 32 | hsa-miR-24-2-5p | BCL2 | 1.27 | 0 | -0.91 | 1.0E-5 | miRNAWalker2 validate; miRTarBase | -0.49 | 0 | NA | |
| 33 | hsa-miR-29a-5p | BCL2 | 0.32 | 0.03704 | -0.91 | 1.0E-5 | mirMAP | -0.16 | 0.00917 | 20041405 | Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 |
| 34 | hsa-miR-365a-3p | BCL2 | 0.45 | 0.00234 | -0.91 | 1.0E-5 | miRNAWalker2 validate; miRTarBase | -0.62 | 0 | NA | |
| 35 | hsa-miR-450b-5p | BCL2 | 1.26 | 0 | -0.91 | 1.0E-5 | mirMAP | -0.3 | 0 | NA | |
| 36 | hsa-miR-452-5p | BCL2 | 0.37 | 0.03485 | -0.91 | 1.0E-5 | mirMAP | -0.29 | 0 | NA | |
| 37 | hsa-miR-455-5p | BCL2 | 1.41 | 0 | -0.91 | 1.0E-5 | mirMAP | -0.67 | 0 | NA | |
| 38 | hsa-miR-542-3p | BCL2 | 0.64 | 0 | -0.91 | 1.0E-5 | mirMAP | -0.3 | 2.0E-5 | NA | |
| 39 | hsa-miR-590-5p | BCL2 | 0.76 | 0 | -0.91 | 1.0E-5 | miRanda | -0.21 | 0.00251 | NA | |
| 40 | hsa-miR-7-5p | BCL2 | 1.56 | 0 | -0.91 | 1.0E-5 | miRNAWalker2 validate; miRTarBase; mirMAP | -0.24 | 0 | 26464649; 25862909; 21750649 | Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions |
| 41 | hsa-miR-338-5p | BID | -1.72 | 0 | 0.97 | 0 | MirTarget | -0.15 | 0 | NA | |
| 42 | hsa-miR-369-3p | BIRC3 | -1.23 | 0 | 0.2 | 0.3995 | MirTarget; miRNATAP | -0.25 | 0 | NA | |
| 43 | hsa-miR-34a-5p | CAPN1 | -0.12 | 0.364 | -0.35 | 0.00055 | miRNAWalker2 validate | -0.18 | 0 | NA | |
| 44 | hsa-miR-491-5p | CAPN1 | -0.54 | 0.00136 | -0.35 | 0.00055 | miRanda | -0.12 | 2.0E-5 | NA | |
| 45 | hsa-miR-16-2-3p | CAPN2 | 1.16 | 0 | -0.39 | 3.0E-5 | mirMAP | -0.1 | 7.0E-5 | NA | |
| 46 | hsa-miR-320a | CAPN2 | 0.8 | 0 | -0.39 | 3.0E-5 | miRanda | -0.14 | 0 | NA | |
| 47 | hsa-miR-320b | CAPN2 | 1.23 | 0 | -0.39 | 3.0E-5 | miRanda | -0.11 | 0 | NA | |
| 48 | hsa-miR-590-5p | CAPN2 | 0.76 | 0 | -0.39 | 3.0E-5 | miRanda | -0.1 | 0.00115 | NA | |
| 49 | hsa-miR-125a-5p | CASP10 | 0.22 | 0.11955 | 0.04 | 0.78895 | mirMAP | -0.16 | 0.00042 | NA | |
| 50 | hsa-miR-145-3p | CASP10 | -1.31 | 0 | 0.04 | 0.78895 | mirMAP | -0.19 | 5.0E-5 | NA | |
| 51 | hsa-miR-145-5p | CASP10 | -0.47 | 0.00069 | 0.04 | 0.78895 | mirMAP | -0.21 | 0 | NA | |
| 52 | hsa-miR-28-3p | CASP10 | 0.46 | 0 | 0.04 | 0.78895 | mirMAP | -0.23 | 0.00093 | NA | |
| 53 | hsa-miR-320a | CASP10 | 0.8 | 0 | 0.04 | 0.78895 | miRanda | -0.13 | 0.00592 | NA | |
| 54 | hsa-miR-339-5p | CASP10 | 1.08 | 0 | 0.04 | 0.78895 | MirTarget | -0.1 | 0.00304 | NA | |
| 55 | hsa-miR-361-5p | CASP10 | 0.08 | 0.31404 | 0.04 | 0.78895 | miRanda | -0.23 | 0.00452 | NA | |
| 56 | hsa-miR-744-3p | CASP10 | 1.19 | 0 | 0.04 | 0.78895 | mirMAP | -0.15 | 1.0E-5 | NA | |
| 57 | hsa-miR-361-5p | CASP7 | 0.08 | 0.31404 | 0.36 | 0.00041 | PITA; miRanda | -0.33 | 0 | NA | |
| 58 | hsa-miR-664a-3p | CASP7 | -0.26 | 0.05132 | 0.36 | 0.00041 | MirTarget | -0.14 | 3.0E-5 | NA | |
| 59 | hsa-miR-193b-3p | CASP9 | 1.73 | 0 | -0.46 | 0 | miRNAWalker2 validate | -0.15 | 0 | NA | |
| 60 | hsa-miR-424-5p | CASP9 | 1.48 | 0 | -0.46 | 0 | mirMAP | -0.14 | 0 | NA | |
| 61 | hsa-miR-7-5p | CASP9 | 1.56 | 0 | -0.46 | 0 | miRNAWalker2 validate | -0.1 | 0 | NA | |
| 62 | hsa-miR-130a-3p | CFLAR | 0.67 | 0 | -0.35 | 0.00043 | mirMAP | -0.13 | 1.0E-5 | NA | |
| 63 | hsa-miR-130b-3p | CFLAR | 1.45 | 0 | -0.35 | 0.00043 | mirMAP | -0.18 | 0 | NA | |
| 64 | hsa-miR-708-5p | CFLAR | 1.54 | 0 | -0.35 | 0.00043 | mirMAP | -0.12 | 0 | NA | |
| 65 | hsa-miR-19a-3p | CSF2RB | 1.36 | 0 | -0.37 | 0.08597 | MirTarget | -0.32 | 0 | NA | |
| 66 | hsa-miR-19b-3p | CSF2RB | 0.54 | 0.00062 | -0.37 | 0.08597 | MirTarget | -0.36 | 0 | NA | |
| 67 | hsa-miR-452-3p | CSF2RB | 1.1 | 0 | -0.37 | 0.08597 | mirMAP | -0.2 | 1.0E-5 | NA | |
| 68 | hsa-miR-455-5p | CSF2RB | 1.41 | 0 | -0.37 | 0.08597 | miRanda | -0.35 | 0 | NA | |
| 69 | hsa-miR-485-3p | CSF2RB | 0.36 | 0.09294 | -0.37 | 0.08597 | MirTarget | -0.12 | 0.0086 | NA | |
| 70 | hsa-miR-493-3p | CSF2RB | -0.59 | 0.00436 | -0.37 | 0.08597 | MirTarget | -0.12 | 0.00918 | NA | |
| 71 | hsa-miR-576-5p | CSF2RB | 0.94 | 0 | -0.37 | 0.08597 | miRNATAP | -0.19 | 0.00484 | NA | |
| 72 | hsa-miR-125a-3p | CYCS | 0.12 | 0.44483 | -0.13 | 0.13395 | miRanda | -0.11 | 3.0E-5 | NA | |
| 73 | hsa-miR-26a-5p | DFFA | -1.09 | 0 | 0.11 | 0.16666 | mirMAP | -0.17 | 0 | NA | |
| 74 | hsa-miR-374b-5p | DFFA | -0.29 | 0.00415 | 0.11 | 0.16666 | mirMAP | -0.11 | 0.00054 | NA | |
| 75 | hsa-miR-628-5p | DFFA | -0.55 | 5.0E-5 | 0.11 | 0.16666 | mirMAP | -0.11 | 0 | NA | |
| 76 | hsa-miR-365a-3p | DFFB | 0.45 | 0.00234 | 0.13 | 0.25677 | MirTarget | -0.15 | 1.0E-5 | NA | |
| 77 | hsa-miR-130b-3p | ENDOD1 | 1.45 | 0 | -0.55 | 0.00014 | MirTarget | -0.32 | 0 | NA | |
| 78 | hsa-miR-16-1-3p | ENDOD1 | 0.96 | 0 | -0.55 | 0.00014 | mirMAP | -0.34 | 0 | NA | |
| 79 | hsa-miR-181c-5p | ENDOD1 | -0.17 | 0.19695 | -0.55 | 0.00014 | MirTarget | -0.32 | 0 | NA | |
| 80 | hsa-miR-181d-5p | ENDOD1 | 0.37 | 0.00537 | -0.55 | 0.00014 | MirTarget | -0.21 | 1.0E-5 | NA | |
| 81 | hsa-miR-192-5p | ENDOD1 | 0.38 | 0.00987 | -0.55 | 0.00014 | miRNAWalker2 validate | -0.28 | 0 | NA | |
| 82 | hsa-miR-19a-3p | ENDOD1 | 1.36 | 0 | -0.55 | 0.00014 | mirMAP | -0.14 | 1.0E-5 | NA | |
| 83 | hsa-miR-19b-3p | ENDOD1 | 0.54 | 0.00062 | -0.55 | 0.00014 | mirMAP | -0.18 | 1.0E-5 | NA | |
| 84 | hsa-miR-200b-3p | ENDOD1 | 0.07 | 0.68286 | -0.55 | 0.00014 | TargetScan | -0.24 | 0 | NA | |
| 85 | hsa-miR-205-3p | ENDOD1 | 1.3 | 0 | -0.55 | 0.00014 | mirMAP | -0.13 | 3.0E-5 | NA | |
| 86 | hsa-miR-20a-3p | ENDOD1 | 1.35 | 0 | -0.55 | 0.00014 | MirTarget | -0.1 | 0.00166 | NA | |
| 87 | hsa-miR-26b-3p | ENDOD1 | 0.42 | 0.00223 | -0.55 | 0.00014 | mirMAP | -0.18 | 8.0E-5 | NA | |
| 88 | hsa-miR-330-5p | ENDOD1 | 0.94 | 0 | -0.55 | 0.00014 | miRanda | -0.15 | 0.00219 | NA | |
| 89 | hsa-miR-335-3p | ENDOD1 | 0.34 | 0.05424 | -0.55 | 0.00014 | MirTarget | -0.19 | 0 | NA | |
| 90 | hsa-miR-3607-3p | ENDOD1 | 1.01 | 9.0E-5 | -0.55 | 0.00014 | MirTarget; miRNATAP | -0.13 | 0 | NA | |
| 91 | hsa-miR-3613-5p | ENDOD1 | 0.41 | 0.00535 | -0.55 | 0.00014 | MirTarget | -0.2 | 0 | NA | |
| 92 | hsa-miR-429 | ENDOD1 | 0.56 | 0.00564 | -0.55 | 0.00014 | miRanda; miRNATAP | -0.18 | 0 | NA | |
| 93 | hsa-miR-454-3p | ENDOD1 | 1.54 | 0 | -0.55 | 0.00014 | MirTarget | -0.16 | 1.0E-5 | NA | |
| 94 | hsa-miR-589-5p | ENDOD1 | 0.81 | 0 | -0.55 | 0.00014 | MirTarget | -0.3 | 0 | NA | |
| 95 | hsa-miR-590-3p | ENDOD1 | 0.22 | 0.09659 | -0.55 | 0.00014 | miRanda | -0.28 | 0 | NA | |
| 96 | hsa-miR-24-3p | EXOG | 0.13 | 0.20389 | 0.35 | 7.0E-5 | MirTarget | -0.19 | 0 | NA | |
| 97 | hsa-miR-146a-5p | FADD | -0.02 | 0.90588 | 1.28 | 0 | miRNAWalker2 validate; miRTarBase | -0.13 | 0.00824 | NA | |
| 98 | hsa-miR-361-5p | FAS | 0.08 | 0.31404 | -0.35 | 0.02248 | miRanda | -0.25 | 0.00313 | NA | |
| 99 | hsa-miR-590-5p | FAS | 0.76 | 0 | -0.35 | 0.02248 | miRanda | -0.18 | 0.00052 | NA | |
| 100 | hsa-let-7e-5p | FASLG | 0.09 | 0.51287 | 0.39 | 0.21882 | miRNATAP | -0.35 | 0.00097 | NA | |
| 101 | hsa-miR-199a-5p | FASLG | -0.36 | 0.04351 | 0.39 | 0.21882 | miRanda | -0.27 | 0.0004 | NA | |
| 102 | hsa-miR-452-3p | FASLG | 1.1 | 0 | 0.39 | 0.21882 | mirMAP | -0.3 | 0 | NA | |
| 103 | hsa-miR-125a-3p | IKBKB | 0.12 | 0.44483 | -0.4 | 2.0E-5 | miRanda | -0.11 | 6.0E-5 | NA | |
| 104 | hsa-miR-151a-3p | IKBKB | 0.13 | 0.29527 | -0.4 | 2.0E-5 | miRNAWalker2 validate | -0.1 | 0.0014 | NA | |
| 105 | hsa-miR-542-3p | IKBKB | 0.64 | 0 | -0.4 | 2.0E-5 | miRanda | -0.16 | 0 | NA | |
| 106 | hsa-miR-107 | IKBKG | -0.04 | 0.67162 | 0.57 | 0 | miRanda | -0.19 | 0 | NA | |
| 107 | hsa-miR-143-3p | IKBKG | -1.34 | 0 | 0.57 | 0 | mirMAP | -0.14 | 0 | NA | |
| 108 | hsa-miR-338-5p | IKBKG | -1.72 | 0 | 0.57 | 0 | mirMAP | -0.12 | 0 | NA | |
| 109 | hsa-miR-140-5p | IL1A | -0.41 | 0.00014 | 2.01 | 0 | miRanda | -0.46 | 0.00165 | NA | |
| 110 | hsa-miR-181c-5p | IL1A | -0.17 | 0.19695 | 2.01 | 0 | MirTarget | -0.78 | 0 | NA | |
| 111 | hsa-miR-181d-5p | IL1A | 0.37 | 0.00537 | 2.01 | 0 | MirTarget | -0.56 | 0 | NA | |
| 112 | hsa-miR-30a-5p | IL1A | -1.8 | 0 | 2.01 | 0 | MirTarget | -0.54 | 0 | NA | |
| 113 | hsa-miR-30b-5p | IL1A | -0.4 | 0.00347 | 2.01 | 0 | MirTarget | -0.43 | 0.00022 | NA | |
| 114 | hsa-miR-30d-5p | IL1A | -0.38 | 0.00017 | 2.01 | 0 | MirTarget | -0.87 | 0 | NA | |
| 115 | hsa-miR-30e-5p | IL1A | -1.02 | 0 | 2.01 | 0 | MirTarget | -0.77 | 0 | NA | |
| 116 | hsa-miR-335-5p | IL1A | -1.17 | 0 | 2.01 | 0 | miRNAWalker2 validate | -0.51 | 0 | NA | |
| 117 | hsa-miR-493-5p | IL1A | -0.47 | 0.02213 | 2.01 | 0 | MirTarget | -0.26 | 0.00094 | NA | |
| 118 | hsa-miR-532-5p | IL1A | -0.02 | 0.83099 | 2.01 | 0 | MirTarget | -0.73 | 0 | NA | |
| 119 | hsa-miR-664a-3p | IL1A | -0.26 | 0.05132 | 2.01 | 0 | MirTarget | -0.51 | 2.0E-5 | NA | |
| 120 | hsa-miR-30a-3p | IL1B | -2.26 | 0 | 0.99 | 0.00035 | MirTarget | -0.23 | 7.0E-5 | NA | |
| 121 | hsa-miR-30e-3p | IL1B | -0.89 | 0 | 0.99 | 0.00035 | MirTarget | -0.36 | 0.00102 | NA | |
| 122 | hsa-miR-495-3p | IL1B | -1.48 | 0 | 0.99 | 0.00035 | MirTarget | -0.27 | 0 | NA | |
| 123 | hsa-miR-130b-5p | IL1R1 | 1.77 | 0 | -0.26 | 0.08776 | mirMAP | -0.14 | 0.00042 | NA | |
| 124 | hsa-miR-17-3p | IL1R1 | -0.01 | 0.90956 | -0.26 | 0.08776 | mirMAP | -0.46 | 0 | NA | |
| 125 | hsa-miR-186-5p | IL1R1 | 0.35 | 0.00015 | -0.26 | 0.08776 | mirMAP | -0.39 | 0 | NA | |
| 126 | hsa-miR-192-5p | IL1R1 | 0.38 | 0.00987 | -0.26 | 0.08776 | miRNAWalker2 validate | -0.16 | 0.0003 | NA | |
| 127 | hsa-miR-197-3p | IL1R1 | 0.88 | 0 | -0.26 | 0.08776 | miRNAWalker2 validate | -0.21 | 0.00036 | NA | |
| 128 | hsa-miR-26b-5p | IL1R1 | -0.25 | 0.02852 | -0.26 | 0.08776 | mirMAP | -0.27 | 0 | NA | |
| 129 | hsa-miR-30d-3p | IL1R1 | -0.58 | 0 | -0.26 | 0.08776 | mirMAP | -0.35 | 0 | NA | |
| 130 | hsa-miR-335-3p | IL1R1 | 0.34 | 0.05424 | -0.26 | 0.08776 | mirMAP | -0.17 | 0 | NA | |
| 131 | hsa-miR-361-5p | IL1R1 | 0.08 | 0.31404 | -0.26 | 0.08776 | miRanda | -0.28 | 0.00096 | NA | |
| 132 | hsa-miR-590-3p | IL1R1 | 0.22 | 0.09659 | -0.26 | 0.08776 | miRanda; miRNATAP | -0.21 | 2.0E-5 | NA | |
| 133 | hsa-miR-106a-5p | IL1RAP | 0.68 | 0.00222 | 0.49 | 0.00341 | MirTarget | -0.12 | 0.00024 | NA | |
| 134 | hsa-miR-140-5p | IL1RAP | -0.41 | 0.00014 | 0.49 | 0.00341 | miRanda | -0.24 | 0.00052 | NA | |
| 135 | hsa-miR-17-5p | IL1RAP | 1.42 | 0 | 0.49 | 0.00341 | MirTarget; TargetScan | -0.13 | 0.00413 | NA | |
| 136 | hsa-miR-186-5p | IL1RAP | 0.35 | 0.00015 | 0.49 | 0.00341 | mirMAP | -0.26 | 0.0012 | NA | |
| 137 | hsa-miR-192-5p | IL1RAP | 0.38 | 0.00987 | 0.49 | 0.00341 | miRNAWalker2 validate | -0.14 | 0.00681 | NA | |
| 138 | hsa-miR-199a-5p | IL1RAP | -0.36 | 0.04351 | 0.49 | 0.00341 | miRanda | -0.11 | 0.00958 | NA | |
| 139 | hsa-miR-199b-5p | IL1RAP | -1.08 | 0 | 0.49 | 0.00341 | miRanda | -0.11 | 0.00568 | NA | |
| 140 | hsa-miR-19a-3p | IL1RAP | 1.36 | 0 | 0.49 | 0.00341 | MirTarget | -0.14 | 0.00023 | NA | |
| 141 | hsa-miR-19b-3p | IL1RAP | 0.54 | 0.00062 | 0.49 | 0.00341 | MirTarget | -0.24 | 0 | NA | |
| 142 | hsa-miR-20a-5p | IL1RAP | 1.15 | 0 | 0.49 | 0.00341 | MirTarget | -0.17 | 5.0E-5 | NA | |
| 143 | hsa-miR-20b-5p | IL1RAP | 0.35 | 0.23201 | 0.49 | 0.00341 | MirTarget | -0.16 | 0 | NA | |
| 144 | hsa-miR-217 | IL1RAP | -1.35 | 0 | 0.49 | 0.00341 | miRanda | -0.12 | 0.0002 | NA | |
| 145 | hsa-miR-29b-3p | IL1RAP | -0.11 | 0.51126 | 0.49 | 0.00341 | MirTarget; miRNATAP | -0.19 | 1.0E-5 | NA | |
| 146 | hsa-miR-320a | IL1RAP | 0.8 | 0 | 0.49 | 0.00341 | MirTarget; PITA; miRanda | -0.26 | 0 | NA | |
| 147 | hsa-miR-335-3p | IL1RAP | 0.34 | 0.05424 | 0.49 | 0.00341 | mirMAP | -0.17 | 4.0E-5 | NA | |
| 148 | hsa-miR-339-5p | IL1RAP | 1.08 | 0 | 0.49 | 0.00341 | miRanda | -0.1 | 0.00939 | NA | |
| 149 | hsa-miR-361-5p | IL1RAP | 0.08 | 0.31404 | 0.49 | 0.00341 | miRanda | -0.26 | 0.00559 | NA | |
| 150 | hsa-miR-362-3p | IL1RAP | -0.7 | 0 | 0.49 | 0.00341 | miRanda | -0.17 | 0.00046 | NA |
| Num | GO | Overlap | Size | P Value | Adj. P Value |
|---|---|---|---|---|---|
| 1 | CELL DEATH | 34 | 1001 | 7.014e-29 | 1.088e-25 |
| 2 | APOPTOTIC SIGNALING PATHWAY | 24 | 289 | 5.926e-29 | 1.088e-25 |
| 3 | EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS | 15 | 39 | 5.1e-29 | 1.088e-25 |
| 4 | POSITIVE REGULATION OF RESPONSE TO STIMULUS | 41 | 1929 | 5.007e-28 | 4.659e-25 |
| 5 | EXTRINSIC APOPTOTIC SIGNALING PATHWAY | 18 | 99 | 4.87e-28 | 4.659e-25 |
| 6 | REGULATION OF CELL DEATH | 37 | 1472 | 3.428e-27 | 2.658e-24 |
| 7 | POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS | 37 | 1492 | 5.547e-27 | 3.687e-24 |
| 8 | INTRACELLULAR SIGNAL TRANSDUCTION | 37 | 1572 | 3.559e-26 | 2.07e-23 |
| 9 | ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY | 16 | 95 | 2.25e-24 | 1.163e-21 |
| 10 | POSITIVE REGULATION OF MOLECULAR FUNCTION | 37 | 1791 | 3.582e-24 | 1.667e-21 |
| 11 | POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION | 29 | 876 | 8e-24 | 3.384e-21 |
| 12 | ZYMOGEN ACTIVATION | 16 | 112 | 3.746e-23 | 1.452e-20 |
| 13 | REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION | 35 | 1656 | 6.451e-23 | 2.309e-20 |
| 14 | POSITIVE REGULATION OF CELL COMMUNICATION | 34 | 1532 | 8.051e-23 | 2.676e-20 |
| 15 | NEGATIVE REGULATION OF CELL DEATH | 28 | 872 | 1.447e-22 | 4.489e-20 |
| 16 | CELLULAR RESPONSE TO ORGANIC SUBSTANCE | 36 | 1848 | 1.669e-22 | 4.853e-20 |
| 17 | REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY | 18 | 213 | 9.363e-22 | 2.563e-19 |
| 18 | IMMUNE SYSTEM PROCESS | 36 | 1984 | 1.849e-21 | 4.75e-19 |
| 19 | POSITIVE REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING | 17 | 179 | 1.94e-21 | 4.75e-19 |
| 20 | REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING | 18 | 233 | 4.828e-21 | 1.123e-18 |
| 21 | POSITIVE REGULATION OF PEPTIDASE ACTIVITY | 16 | 154 | 7.698e-21 | 1.706e-18 |
| 22 | RESPONSE TO OXYGEN CONTAINING COMPOUND | 31 | 1381 | 1.21e-20 | 2.558e-18 |
| 23 | PROTEIN MATURATION | 18 | 265 | 4.989e-20 | 1.009e-17 |
| 24 | RESPONSE TO CYTOKINE | 24 | 714 | 1.349e-19 | 2.616e-17 |
| 25 | POSITIVE REGULATION OF CATALYTIC ACTIVITY | 31 | 1518 | 1.904e-19 | 3.544e-17 |
| 26 | POSITIVE REGULATION OF CELL DEATH | 22 | 605 | 1.25e-18 | 2.237e-16 |
| 27 | NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY | 13 | 98 | 1.759e-18 | 3.031e-16 |
| 28 | REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY | 14 | 153 | 1.644e-17 | 2.733e-15 |
| 29 | CELLULAR RESPONSE TO CYTOKINE STIMULUS | 21 | 606 | 2.426e-17 | 3.892e-15 |
| 30 | CYTOKINE MEDIATED SIGNALING PATHWAY | 19 | 452 | 3.202e-17 | 4.967e-15 |
| 31 | REGULATION OF PEPTIDASE ACTIVITY | 18 | 392 | 5.391e-17 | 8.092e-15 |
| 32 | POSITIVE REGULATION OF PROTEOLYSIS | 17 | 363 | 3.301e-16 | 4.655e-14 |
| 33 | REGULATION OF APOPTOTIC SIGNALING PATHWAY | 17 | 363 | 3.301e-16 | 4.655e-14 |
| 34 | REGULATION OF PROTEOLYSIS | 21 | 711 | 5.99e-16 | 8.197e-14 |
| 35 | ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY | 7 | 13 | 2.576e-15 | 3.425e-13 |
| 36 | RESPONSE TO BIOTIC STIMULUS | 22 | 886 | 3.681e-15 | 4.757e-13 |
| 37 | POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS | 24 | 1135 | 4.95e-15 | 6.225e-13 |
| 38 | REGULATION OF IMMUNE SYSTEM PROCESS | 26 | 1403 | 5.415e-15 | 6.63e-13 |
| 39 | CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND | 21 | 799 | 6.059e-15 | 7.163e-13 |
| 40 | RESPONSE TO ABIOTIC STIMULUS | 23 | 1024 | 6.158e-15 | 7.163e-13 |
| 41 | POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS | 23 | 1036 | 7.895e-15 | 8.747e-13 |
| 42 | POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS | 23 | 1036 | 7.895e-15 | 8.747e-13 |
| 43 | INFLAMMATORY RESPONSE | 17 | 454 | 1.325e-14 | 1.433e-12 |
| 44 | REGULATION OF TRANSFERASE ACTIVITY | 22 | 946 | 1.412e-14 | 1.493e-12 |
| 45 | REGULATION OF PHOSPHORUS METABOLIC PROCESS | 27 | 1618 | 1.69e-14 | 1.747e-12 |
| 46 | REGULATION OF IMMUNE RESPONSE | 21 | 858 | 2.458e-14 | 2.334e-12 |
| 47 | INTRINSIC APOPTOTIC SIGNALING PATHWAY | 12 | 152 | 2.445e-14 | 2.334e-12 |
| 48 | NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY | 13 | 200 | 2.311e-14 | 2.334e-12 |
| 49 | RESPONSE TO MOLECULE OF BACTERIAL ORIGIN | 15 | 321 | 2.418e-14 | 2.334e-12 |
| 50 | RESPONSE TO NITROGEN COMPOUND | 21 | 859 | 2.515e-14 | 2.34e-12 |
| 51 | POSITIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY | 7 | 17 | 2.893e-14 | 2.602e-12 |
| 52 | POSITIVE REGULATION OF IMMUNE RESPONSE | 18 | 563 | 2.908e-14 | 2.602e-12 |
| 53 | CELLULAR RESPONSE TO ABIOTIC STIMULUS | 14 | 263 | 3.308e-14 | 2.904e-12 |
| 54 | POSITIVE REGULATION OF KINASE ACTIVITY | 17 | 482 | 3.519e-14 | 3.033e-12 |
| 55 | CELLULAR RESPONSE TO MECHANICAL STIMULUS | 10 | 80 | 3.759e-14 | 3.18e-12 |
| 56 | REGULATION OF KINASE ACTIVITY | 20 | 776 | 4.559e-14 | 3.788e-12 |
| 57 | NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS | 8 | 34 | 6.899e-14 | 5.632e-12 |
| 58 | ACTIVATION OF PROTEIN KINASE ACTIVITY | 14 | 279 | 7.456e-14 | 5.982e-12 |
| 59 | ACTIVATION OF IMMUNE RESPONSE | 16 | 427 | 8.934e-14 | 7.046e-12 |
| 60 | POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY | 12 | 171 | 1.013e-13 | 7.859e-12 |
| 61 | POSITIVE REGULATION OF DEFENSE RESPONSE | 15 | 364 | 1.513e-13 | 1.154e-11 |
| 62 | POSITIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY | 11 | 132 | 1.765e-13 | 1.324e-11 |
| 63 | PROTEOLYSIS | 23 | 1208 | 2.03e-13 | 1.499e-11 |
| 64 | REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY | 7 | 22 | 2.507e-13 | 1.823e-11 |
| 65 | RESPONSE TO EXTERNAL STIMULUS | 27 | 1821 | 2.964e-13 | 2.122e-11 |
| 66 | POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS | 20 | 867 | 3.591e-13 | 2.532e-11 |
| 67 | REGULATION OF PROTEIN MODIFICATION PROCESS | 26 | 1710 | 5.638e-13 | 3.915e-11 |
| 68 | I KAPPAB KINASE NF KAPPAB SIGNALING | 9 | 70 | 5.933e-13 | 4.059e-11 |
| 69 | CELLULAR RESPONSE TO EXTERNAL STIMULUS | 13 | 264 | 8.178e-13 | 5.515e-11 |
| 70 | RESPONSE TO ENDOGENOUS STIMULUS | 24 | 1450 | 1.046e-12 | 6.953e-11 |
| 71 | CELLULAR RESPONSE TO NITROGEN COMPOUND | 16 | 505 | 1.16e-12 | 7.605e-11 |
| 72 | RESPONSE TO MECHANICAL STIMULUS | 12 | 210 | 1.178e-12 | 7.613e-11 |
| 73 | POSITIVE REGULATION OF TRANSFERASE ACTIVITY | 17 | 616 | 1.835e-12 | 1.17e-10 |
| 74 | TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY | 10 | 118 | 2.04e-12 | 1.283e-10 |
| 75 | RESPONSE TO BACTERIUM | 16 | 528 | 2.278e-12 | 1.413e-10 |
| 76 | PHOSPHORYLATION | 22 | 1228 | 2.712e-12 | 1.66e-10 |
| 77 | IMMUNE RESPONSE | 21 | 1100 | 2.991e-12 | 1.807e-10 |
| 78 | POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY | 12 | 228 | 3.115e-12 | 1.858e-10 |
| 79 | RESPONSE TO TUMOR NECROSIS FACTOR | 12 | 233 | 4.022e-12 | 2.369e-10 |
| 80 | REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS | 8 | 55 | 4.407e-12 | 2.563e-10 |
| 81 | SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND | 7 | 33 | 6.122e-12 | 3.391e-10 |
| 82 | RESPONSE TO LIPID | 19 | 888 | 6.027e-12 | 3.391e-10 |
| 83 | EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND | 7 | 33 | 6.122e-12 | 3.391e-10 |
| 84 | REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY | 15 | 470 | 5.955e-12 | 3.391e-10 |
| 85 | NEURON APOPTOTIC PROCESS | 7 | 35 | 9.592e-12 | 5.251e-10 |
| 86 | IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY | 13 | 323 | 1.045e-11 | 5.652e-10 |
| 87 | REGULATION OF RESPONSE TO STRESS | 23 | 1468 | 1.142e-11 | 6.11e-10 |
| 88 | FC EPSILON RECEPTOR SIGNALING PATHWAY | 10 | 142 | 1.316e-11 | 6.96e-10 |
| 89 | PROTEIN PHOSPHORYLATION | 19 | 944 | 1.74e-11 | 9.095e-10 |
| 90 | ACTIVATION OF INNATE IMMUNE RESPONSE | 11 | 204 | 2.101e-11 | 1.086e-09 |
| 91 | PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY | 9 | 109 | 3.555e-11 | 1.818e-09 |
| 92 | INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE | 8 | 71 | 3.711e-11 | 1.877e-09 |
| 93 | REGULATION OF DEFENSE RESPONSE | 17 | 759 | 4.937e-11 | 2.47e-09 |
| 94 | NEURON DEATH | 7 | 47 | 8.725e-11 | 4.319e-09 |
| 95 | REGULATION OF HYDROLASE ACTIVITY | 21 | 1327 | 1.017e-10 | 4.98e-09 |
| 96 | PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS | 25 | 1977 | 1.08e-10 | 5.234e-09 |
| 97 | HOMEOSTATIC PROCESS | 21 | 1337 | 1.169e-10 | 5.606e-09 |
| 98 | PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS | 7 | 49 | 1.186e-10 | 5.632e-09 |
| 99 | REGULATION OF CELL PROLIFERATION | 22 | 1496 | 1.285e-10 | 6.041e-09 |
| 100 | POSITIVE REGULATION OF INNATE IMMUNE RESPONSE | 11 | 246 | 1.571e-10 | 7.309e-09 |
| 101 | TOLL LIKE RECEPTOR SIGNALING PATHWAY | 8 | 85 | 1.625e-10 | 7.486e-09 |
| 102 | REGULATION OF NEURON DEATH | 11 | 252 | 2.031e-10 | 9.266e-09 |
| 103 | ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY | 10 | 195 | 3.042e-10 | 1.365e-08 |
| 104 | CELLULAR RESPONSE TO STRESS | 22 | 1565 | 3.051e-10 | 1.365e-08 |
| 105 | REGULATION OF RESPONSE TO CYTOKINE STIMULUS | 9 | 144 | 4.373e-10 | 1.938e-08 |
| 106 | CELLULAR RESPONSE TO ENDOGENOUS STIMULUS | 18 | 1008 | 4.697e-10 | 2.062e-08 |
| 107 | T CELL RECEPTOR SIGNALING PATHWAY | 9 | 146 | 4.946e-10 | 2.151e-08 |
| 108 | FC RECEPTOR SIGNALING PATHWAY | 10 | 206 | 5.201e-10 | 2.241e-08 |
| 109 | REGULATION OF INNATE IMMUNE RESPONSE | 12 | 357 | 5.642e-10 | 2.409e-08 |
| 110 | RESPONSE TO HORMONE | 17 | 893 | 6.072e-10 | 2.568e-08 |
| 111 | REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY | 12 | 365 | 7.26e-10 | 3.044e-08 |
| 112 | POSITIVE REGULATION OF HYDROLASE ACTIVITY | 17 | 905 | 7.443e-10 | 3.092e-08 |
| 113 | POSITIVE REGULATION OF NEURON DEATH | 7 | 67 | 1.152e-09 | 4.742e-08 |
| 114 | NEGATIVE REGULATION OF RESPONSE TO STIMULUS | 20 | 1360 | 1.18e-09 | 4.816e-08 |
| 115 | DEFENSE RESPONSE | 19 | 1231 | 1.566e-09 | 6.336e-08 |
| 116 | RESPONSE TO INTERLEUKIN 1 | 8 | 115 | 1.863e-09 | 7.472e-08 |
| 117 | RESPONSE TO PEPTIDE | 12 | 404 | 2.289e-09 | 9.105e-08 |
| 118 | PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS | 8 | 120 | 2.616e-09 | 1.032e-07 |
| 119 | CHEMICAL HOMEOSTASIS | 16 | 874 | 3.793e-09 | 1.483e-07 |
| 120 | NEGATIVE REGULATION OF CELL COMMUNICATION | 18 | 1192 | 6.701e-09 | 2.598e-07 |
| 121 | CELLULAR RESPONSE TO INTERLEUKIN 1 | 7 | 88 | 8.006e-09 | 3.079e-07 |
| 122 | REGULATION OF TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY | 6 | 50 | 8.088e-09 | 3.085e-07 |
| 123 | RESPONSE TO WOUNDING | 13 | 563 | 9.34e-09 | 3.533e-07 |
| 124 | PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING | 5 | 25 | 1.04e-08 | 3.902e-07 |
| 125 | WOUND HEALING | 12 | 470 | 1.242e-08 | 4.622e-07 |
| 126 | POSITIVE REGULATION OF GENE EXPRESSION | 21 | 1733 | 1.277e-08 | 4.716e-07 |
| 127 | REGULATION OF INFLAMMATORY RESPONSE | 10 | 294 | 1.594e-08 | 5.84e-07 |
| 128 | NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR SIGNALING PATHWAY | 5 | 28 | 1.91e-08 | 6.944e-07 |
| 129 | CELLULAR RESPONSE TO BIOTIC STIMULUS | 8 | 163 | 2.925e-08 | 1.055e-06 |
| 130 | REGULATION OF MAP KINASE ACTIVITY | 10 | 319 | 3.446e-08 | 1.233e-06 |
| 131 | REGULATION OF ENDOTHELIAL CELL DEVELOPMENT | 4 | 12 | 3.557e-08 | 1.254e-06 |
| 132 | REGULATION OF ESTABLISHMENT OF ENDOTHELIAL BARRIER | 4 | 12 | 3.557e-08 | 1.254e-06 |
| 133 | CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY | 5 | 33 | 4.561e-08 | 1.596e-06 |
| 134 | INTERLEUKIN 1 MEDIATED SIGNALING PATHWAY | 4 | 13 | 5.127e-08 | 1.78e-06 |
| 135 | RESPONSE TO ORGANIC CYCLIC COMPOUND | 15 | 917 | 5.701e-08 | 1.965e-06 |
| 136 | LEUKOCYTE CELL CELL ADHESION | 9 | 255 | 6.485e-08 | 2.219e-06 |
| 137 | CELLULAR RESPONSE TO HORMONE STIMULUS | 12 | 552 | 7.26e-08 | 2.466e-06 |
| 138 | REGULATION OF EPITHELIAL CELL DIFFERENTIATION | 7 | 122 | 7.806e-08 | 2.632e-06 |
| 139 | RESPONSE TO OXIDATIVE STRESS | 10 | 352 | 8.665e-08 | 2.901e-06 |
| 140 | INOSITOL LIPID MEDIATED SIGNALING | 7 | 124 | 8.732e-08 | 2.902e-06 |
| 141 | CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS | 6 | 74 | 8.919e-08 | 2.943e-06 |
| 142 | CELLULAR GLUCOSE HOMEOSTASIS | 6 | 75 | 9.672e-08 | 3.169e-06 |
| 143 | CELL ACTIVATION | 12 | 568 | 9.9e-08 | 3.221e-06 |
| 144 | RESPONSE TO REACTIVE OXYGEN SPECIES | 8 | 191 | 9.998e-08 | 3.231e-06 |
| 145 | REGULATION OF NEURON APOPTOTIC PROCESS | 8 | 192 | 1.041e-07 | 3.34e-06 |
| 146 | PHOSPHATIDYLINOSITOL METABOLIC PROCESS | 8 | 193 | 1.083e-07 | 3.453e-06 |
| 147 | CELLULAR RESPONSE TO PEPTIDE | 9 | 274 | 1.197e-07 | 3.789e-06 |
| 148 | POSITIVE REGULATION OF MAPK CASCADE | 11 | 470 | 1.304e-07 | 4.099e-06 |
| 149 | RESPONSE TO INORGANIC SUBSTANCE | 11 | 479 | 1.577e-07 | 4.925e-06 |
| 150 | NEGATIVE REGULATION OF CATABOLIC PROCESS | 8 | 203 | 1.597e-07 | 4.955e-06 |
| 151 | ACTIVATION OF PROTEIN KINASE A ACTIVITY | 4 | 17 | 1.691e-07 | 5.212e-06 |
| 152 | POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY | 9 | 289 | 1.881e-07 | 5.758e-06 |
| 153 | REGULATION OF CATABOLIC PROCESS | 13 | 731 | 1.975e-07 | 6.008e-06 |
| 154 | LEUKOCYTE DIFFERENTIATION | 9 | 292 | 2.053e-07 | 6.202e-06 |
| 155 | GLYCEROLIPID BIOSYNTHETIC PROCESS | 8 | 211 | 2.147e-07 | 6.447e-06 |
| 156 | REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT | 19 | 1672 | 2.188e-07 | 6.525e-06 |
| 157 | REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND | 5 | 46 | 2.557e-07 | 7.577e-06 |
| 158 | POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS | 5 | 47 | 2.855e-07 | 8.406e-06 |
| 159 | REGULATION OF CELL ADHESION | 12 | 629 | 2.967e-07 | 8.683e-06 |
| 160 | RESPONSE TO OXYGEN LEVELS | 9 | 311 | 3.491e-07 | 1.009e-05 |
| 161 | HEMOSTASIS | 9 | 311 | 3.491e-07 | 1.009e-05 |
| 162 | REGULATION OF RESPONSE TO WOUNDING | 10 | 413 | 3.796e-07 | 1.09e-05 |
| 163 | REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS | 6 | 95 | 3.986e-07 | 1.138e-05 |
| 164 | NECROPTOTIC PROCESS | 4 | 21 | 4.215e-07 | 1.196e-05 |
| 165 | POSITIVE REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS | 5 | 51 | 4.331e-07 | 1.214e-05 |
| 166 | RESPONSE TO NICOTINE | 5 | 51 | 4.331e-07 | 1.214e-05 |
| 167 | NEGATIVE REGULATION OF MOLECULAR FUNCTION | 15 | 1079 | 4.666e-07 | 1.3e-05 |
| 168 | PHOSPHOLIPID BIOSYNTHETIC PROCESS | 8 | 235 | 4.876e-07 | 1.35e-05 |
| 169 | REGULATION OF MAPK CASCADE | 12 | 660 | 4.952e-07 | 1.363e-05 |
| 170 | LIPID PHOSPHORYLATION | 6 | 99 | 5.091e-07 | 1.394e-05 |
| 171 | RESPONSE TO DRUG | 10 | 431 | 5.606e-07 | 1.525e-05 |
| 172 | RENAL SYSTEM PROCESS | 6 | 102 | 6.076e-07 | 1.644e-05 |
| 173 | RESPONSE TO CARBOHYDRATE | 7 | 168 | 6.915e-07 | 1.86e-05 |
| 174 | POSITIVE REGULATION OF BIOSYNTHETIC PROCESS | 19 | 1805 | 7.137e-07 | 1.898e-05 |
| 175 | RESPONSE TO VIRUS | 8 | 247 | 7.104e-07 | 1.898e-05 |
| 176 | GLUCOSE HOMEOSTASIS | 7 | 170 | 7.488e-07 | 1.957e-05 |
| 177 | CARBOHYDRATE HOMEOSTASIS | 7 | 170 | 7.488e-07 | 1.957e-05 |
| 178 | REGULATION OF EXECUTION PHASE OF APOPTOSIS | 4 | 24 | 7.434e-07 | 1.957e-05 |
| 179 | INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY | 6 | 106 | 7.627e-07 | 1.982e-05 |
| 180 | LYMPHOCYTE ACTIVATION | 9 | 342 | 7.724e-07 | 1.997e-05 |
| 181 | RESPONSE TO CORTICOSTEROID | 7 | 176 | 9.455e-07 | 2.431e-05 |
| 182 | CELLULAR RESPONSE TO LIPID | 10 | 457 | 9.542e-07 | 2.44e-05 |
| 183 | SINGLE ORGANISM CELL ADHESION | 10 | 459 | 9.927e-07 | 2.524e-05 |
| 184 | REGULATION OF NECROTIC CELL DEATH | 4 | 26 | 1.041e-06 | 2.633e-05 |
| 185 | RESPONSE TO AMINO ACID | 6 | 112 | 1.055e-06 | 2.653e-05 |
| 186 | IMMUNE SYSTEM DEVELOPMENT | 11 | 582 | 1.084e-06 | 2.712e-05 |
| 187 | CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND | 10 | 465 | 1.116e-06 | 2.777e-05 |
| 188 | AGING | 8 | 264 | 1.172e-06 | 2.892e-05 |
| 189 | POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | 14 | 1004 | 1.175e-06 | 2.892e-05 |
| 190 | POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION | 9 | 360 | 1.182e-06 | 2.894e-05 |
| 191 | REGULATION OF ENDOTHELIAL CELL DIFFERENTIATION | 4 | 27 | 1.22e-06 | 2.971e-05 |
| 192 | NECROTIC CELL DEATH | 4 | 28 | 1.42e-06 | 3.423e-05 |
| 193 | POSITIVE REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA | 4 | 28 | 1.42e-06 | 3.423e-05 |
| 194 | MULTICELLULAR ORGANISMAL HOMEOSTASIS | 8 | 272 | 1.465e-06 | 3.514e-05 |
| 195 | POSITIVE REGULATION OF INTRACELLULAR TRANSPORT | 9 | 370 | 1.482e-06 | 3.536e-05 |
| 196 | NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS | 9 | 372 | 1.549e-06 | 3.677e-05 |
| 197 | REGULATION OF CELL ACTIVATION | 10 | 484 | 1.601e-06 | 3.781e-05 |
| 198 | REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY | 4 | 29 | 1.643e-06 | 3.842e-05 |
| 199 | POSITIVE REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY | 4 | 29 | 1.643e-06 | 3.842e-05 |
| 200 | POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT | 6 | 121 | 1.66e-06 | 3.861e-05 |
| 201 | MYD88 INDEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY | 4 | 30 | 1.892e-06 | 4.379e-05 |
| 202 | REGULATION OF LIPID METABOLIC PROCESS | 8 | 282 | 1.918e-06 | 4.418e-05 |
| 203 | LIPOPOLYSACCHARIDE MEDIATED SIGNALING PATHWAY | 4 | 31 | 2.167e-06 | 4.967e-05 |
| 204 | NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND | 4 | 32 | 2.471e-06 | 5.581e-05 |
| 205 | INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS | 4 | 32 | 2.471e-06 | 5.581e-05 |
| 206 | NEGATIVE REGULATION OF SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND | 4 | 32 | 2.471e-06 | 5.581e-05 |
| 207 | POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION | 10 | 514 | 2.741e-06 | 6.161e-05 |
| 208 | POSITIVE REGULATION OF MAP KINASE ACTIVITY | 7 | 207 | 2.789e-06 | 6.24e-05 |
| 209 | GLYCEROPHOSPHOLIPID METABOLIC PROCESS | 8 | 297 | 2.818e-06 | 6.275e-05 |
| 210 | LYMPHOCYTE DIFFERENTIATION | 7 | 209 | 2.973e-06 | 6.586e-05 |
| 211 | T CELL HOMEOSTASIS | 4 | 34 | 3.173e-06 | 6.93e-05 |
| 212 | RENAL WATER HOMEOSTASIS | 4 | 34 | 3.173e-06 | 6.93e-05 |
| 213 | CELLULAR RESPONSE TO ALKALOID | 4 | 34 | 3.173e-06 | 6.93e-05 |
| 214 | RESPONSE TO ALKALOID | 6 | 137 | 3.42e-06 | 7.435e-05 |
| 215 | LEUKOCYTE ACTIVATION | 9 | 414 | 3.717e-06 | 8.045e-05 |
| 216 | POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY | 4 | 36 | 4.012e-06 | 8.642e-05 |
| 217 | REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT | 7 | 220 | 4.171e-06 | 8.861e-05 |
| 218 | REGULATION OF NECROPTOTIC PROCESS | 3 | 11 | 4.163e-06 | 8.861e-05 |
| 219 | POSITIVE REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS | 3 | 11 | 4.163e-06 | 8.861e-05 |
| 220 | CELLULAR HOMEOSTASIS | 11 | 676 | 4.599e-06 | 9.727e-05 |
| 221 | RESPONSE TO ACID CHEMICAL | 8 | 319 | 4.775e-06 | 0.0001005 |
| 222 | NIK NF KAPPAB SIGNALING | 5 | 83 | 4.975e-06 | 0.0001043 |
| 223 | CELLULAR RESPONSE TO GLUCAGON STIMULUS | 4 | 38 | 5.005e-06 | 0.0001044 |
| 224 | REGULATION OF CELLULAR PROTEIN LOCALIZATION | 10 | 552 | 5.155e-06 | 0.0001071 |
| 225 | NEGATIVE REGULATION OF CATALYTIC ACTIVITY | 12 | 829 | 5.31e-06 | 0.0001098 |
| 226 | REGULATION OF CELL DIFFERENTIATION | 16 | 1492 | 5.458e-06 | 0.0001124 |
| 227 | REGULATION OF VITAMIN METABOLIC PROCESS | 3 | 12 | 5.539e-06 | 0.0001135 |
| 228 | REGULATION OF CYTOKINE PRODUCTION | 10 | 563 | 6.132e-06 | 0.0001251 |
| 229 | CELLULAR CHEMICAL HOMEOSTASIS | 10 | 570 | 6.834e-06 | 0.0001389 |
| 230 | HEPATOCYTE APOPTOTIC PROCESS | 3 | 13 | 7.186e-06 | 0.0001454 |
| 231 | REGULATION OF NIK NF KAPPAB SIGNALING | 4 | 42 | 7.521e-06 | 0.0001514 |
| 232 | RESPONSE TO TOXIC SUBSTANCE | 7 | 241 | 7.583e-06 | 0.0001514 |
| 233 | REGULATION OF ORGANELLE ORGANIZATION | 14 | 1178 | 7.562e-06 | 0.0001514 |
| 234 | POSITIVE REGULATION OF CELL CELL ADHESION | 7 | 243 | 8.003e-06 | 0.0001591 |
| 235 | REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY | 4 | 43 | 8.274e-06 | 0.0001638 |
| 236 | CELLULAR RESPONSE TO DNA DAMAGE STIMULUS | 11 | 720 | 8.361e-06 | 0.0001648 |
| 237 | REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA | 4 | 44 | 9.081e-06 | 0.0001783 |
| 238 | REGULATION OF CAMP DEPENDENT PROTEIN KINASE ACTIVITY | 3 | 14 | 9.126e-06 | 0.0001784 |
| 239 | REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS | 5 | 94 | 9.172e-06 | 0.0001786 |
| 240 | GLYCEROLIPID METABOLIC PROCESS | 8 | 356 | 1.064e-05 | 0.0002062 |
| 241 | POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS | 15 | 1395 | 1.117e-05 | 0.0002157 |
| 242 | T CELL APOPTOTIC PROCESS | 3 | 15 | 1.138e-05 | 0.0002189 |
| 243 | CELL CELL ADHESION | 10 | 608 | 1.2e-05 | 0.0002297 |
| 244 | LEUKOCYTE MIGRATION | 7 | 259 | 1.211e-05 | 0.000231 |
| 245 | PHOSPHOLIPID METABOLIC PROCESS | 8 | 364 | 1.25e-05 | 0.0002364 |
| 246 | REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER | 17 | 1784 | 1.245e-05 | 0.0002364 |
| 247 | RESPONSE TO GLUCAGON | 4 | 48 | 1.29e-05 | 0.000243 |
| 248 | IMMUNE EFFECTOR PROCESS | 9 | 486 | 1.349e-05 | 0.0002532 |
| 249 | POSITIVE REGULATION OF CYTOKINE PRODUCTION | 8 | 370 | 1.406e-05 | 0.0002628 |
| 250 | STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE | 5 | 103 | 1.433e-05 | 0.0002667 |
| 251 | REGULATION OF INTRACELLULAR TRANSPORT | 10 | 621 | 1.441e-05 | 0.0002671 |
| 252 | POSITIVE REGULATION OF PROTEIN IMPORT | 5 | 104 | 1.502e-05 | 0.0002773 |
| 253 | LYMPHOCYTE HOMEOSTASIS | 4 | 50 | 1.52e-05 | 0.0002785 |
| 254 | RESPONSE TO GAMMA RADIATION | 4 | 50 | 1.52e-05 | 0.0002785 |
| 255 | NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS | 13 | 1087 | 1.595e-05 | 0.000291 |
| 256 | RESPONSE TO STEROID HORMONE | 9 | 497 | 1.612e-05 | 0.0002929 |
| 257 | REGULATION OF NFAT PROTEIN IMPORT INTO NUCLEUS | 3 | 17 | 1.694e-05 | 0.0003067 |
| 258 | REGULATION OF CELL CELL ADHESION | 8 | 380 | 1.704e-05 | 0.0003073 |
| 259 | RESPONSE TO KETONE | 6 | 182 | 1.741e-05 | 0.0003128 |
| 260 | POSITIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY | 4 | 52 | 1.779e-05 | 0.0003184 |
| 261 | REGULATION OF PROTEIN IMPORT | 6 | 183 | 1.796e-05 | 0.0003201 |
| 262 | POSITIVE REGULATION OF TRANSPORT | 12 | 936 | 1.802e-05 | 0.0003201 |
| 263 | REGULATION OF BODY FLUID LEVELS | 9 | 506 | 1.857e-05 | 0.0003286 |
| 264 | RESPONSE TO HYDROGEN PEROXIDE | 5 | 109 | 1.886e-05 | 0.0003324 |
| 265 | POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY | 4 | 53 | 1.92e-05 | 0.0003371 |
| 266 | LYMPHOCYTE APOPTOTIC PROCESS | 3 | 18 | 2.028e-05 | 0.0003548 |
| 267 | EXECUTION PHASE OF APOPTOSIS | 4 | 55 | 2.226e-05 | 0.0003879 |
| 268 | ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS | 12 | 957 | 2.245e-05 | 0.0003898 |
| 269 | RESPONSE TO MUSCLE STRETCH | 3 | 19 | 2.404e-05 | 0.0004158 |
| 270 | PROTEIN COMPLEX BIOGENESIS | 13 | 1132 | 2.447e-05 | 0.0004201 |
| 271 | PROTEIN COMPLEX ASSEMBLY | 13 | 1132 | 2.447e-05 | 0.0004201 |
| 272 | SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION | 8 | 404 | 2.642e-05 | 0.000452 |
| 273 | MULTICELLULAR ORGANISMAL WATER HOMEOSTASIS | 4 | 58 | 2.751e-05 | 0.0004671 |
| 274 | POSITIVE REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS | 4 | 58 | 2.751e-05 | 0.0004671 |
| 275 | CELL PROLIFERATION | 10 | 672 | 2.835e-05 | 0.0004797 |
| 276 | POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION | 13 | 1152 | 2.939e-05 | 0.0004945 |
| 277 | REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS | 4 | 59 | 2.944e-05 | 0.0004945 |
| 278 | RESPONSE TO RADIATION | 8 | 413 | 3.091e-05 | 0.0005173 |
| 279 | LEUKOCYTE HOMEOSTASIS | 4 | 60 | 3.147e-05 | 0.0005249 |
| 280 | NEGATIVE REGULATION OF LIPID CATABOLIC PROCESS | 3 | 21 | 3.285e-05 | 0.0005456 |
| 281 | NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION | 10 | 684 | 3.295e-05 | 0.0005456 |
| 282 | T CELL DIFFERENTIATION | 5 | 123 | 3.378e-05 | 0.0005575 |
| 283 | REGULATION OF HOMOTYPIC CELL CELL ADHESION | 7 | 307 | 3.608e-05 | 0.0005933 |
| 284 | POSITIVE REGULATION OF PROTEIN OLIGOMERIZATION | 3 | 22 | 3.796e-05 | 0.0006154 |
| 285 | RELEASE OF CYTOCHROME C FROM MITOCHONDRIA | 3 | 22 | 3.796e-05 | 0.0006154 |
| 286 | RESPONSE TO UV | 5 | 126 | 3.793e-05 | 0.0006154 |
| 287 | NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY | 5 | 126 | 3.793e-05 | 0.0006154 |
| 288 | LIPID MODIFICATION | 6 | 210 | 3.895e-05 | 0.0006293 |
| 289 | POSITIVE REGULATION OF CELL ACTIVATION | 7 | 311 | 3.917e-05 | 0.0006307 |
| 290 | REGULATION OF HEMOPOIESIS | 7 | 314 | 4.163e-05 | 0.000668 |
| 291 | POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS | 5 | 129 | 4.245e-05 | 0.0006787 |
| 292 | LEUKOCYTE APOPTOTIC PROCESS | 3 | 23 | 4.356e-05 | 0.0006941 |
| 293 | RESPONSE TO ESTROGEN | 6 | 218 | 4.798e-05 | 0.0007593 |
| 294 | REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS | 6 | 218 | 4.798e-05 | 0.0007593 |
| 295 | CELLULAR RESPONSE TO DRUG | 4 | 67 | 4.87e-05 | 0.0007682 |
| 296 | POSITIVE REGULATION OF ORGANELLE ORGANIZATION | 9 | 573 | 4.909e-05 | 0.0007717 |
| 297 | ORGANOPHOSPHATE BIOSYNTHETIC PROCESS | 8 | 450 | 5.665e-05 | 0.0008787 |
| 298 | CELLULAR EXTRAVASATION | 3 | 25 | 5.633e-05 | 0.0008787 |
| 299 | EPITHELIAL CELL APOPTOTIC PROCESS | 3 | 25 | 5.633e-05 | 0.0008787 |
| 300 | ACTIVATION OF MAPK ACTIVITY | 5 | 137 | 5.657e-05 | 0.0008787 |
| 301 | WATER HOMEOSTASIS | 4 | 70 | 5.787e-05 | 0.0008916 |
| 302 | REGULATION OF MEMBRANE PERMEABILITY | 4 | 70 | 5.787e-05 | 0.0008916 |
| 303 | RESPONSE TO METAL ION | 7 | 333 | 6.033e-05 | 0.0009265 |
| 304 | DEVELOPMENTAL PROGRAMMED CELL DEATH | 3 | 26 | 6.354e-05 | 0.0009725 |
| 305 | SINGLE ORGANISM CELLULAR LOCALIZATION | 11 | 898 | 6.404e-05 | 0.000977 |
| 306 | PLATELET ACTIVATION | 5 | 142 | 6.708e-05 | 0.00102 |
| 307 | REGULATION OF LEUKOCYTE DIFFERENTIATION | 6 | 232 | 6.776e-05 | 0.001027 |
| 308 | RESPONSE TO ENDOPLASMIC RETICULUM STRESS | 6 | 233 | 6.939e-05 | 0.001045 |
| 309 | CELLULAR RESPONSE TO OXYGEN LEVELS | 5 | 143 | 6.935e-05 | 0.001045 |
| 310 | DNA CATABOLIC PROCESS | 3 | 27 | 7.133e-05 | 0.001071 |
| 311 | CELLULAR LIPID METABOLIC PROCESS | 11 | 913 | 7.43e-05 | 0.001112 |
| 312 | RESPONSE TO ESTRADIOL | 5 | 146 | 7.653e-05 | 0.001141 |
| 313 | POSITIVE REGULATION OF ACUTE INFLAMMATORY RESPONSE | 3 | 28 | 7.972e-05 | 0.001185 |
| 314 | PEPTIDYL SERINE MODIFICATION | 5 | 148 | 8.162e-05 | 0.001206 |
| 315 | RESPONSE TO TRANSITION METAL NANOPARTICLE | 5 | 148 | 8.162e-05 | 0.001206 |
| 316 | REGULATION OF RESPONSE TO EXTERNAL STIMULUS | 11 | 926 | 8.431e-05 | 0.001242 |
| 317 | POSITIVE REGULATION OF NIK NF KAPPAB SIGNALING | 3 | 29 | 8.872e-05 | 0.001298 |
| 318 | MUSCLE ADAPTATION | 3 | 29 | 8.872e-05 | 0.001298 |
| 319 | REGULATION OF CYTOPLASMIC TRANSPORT | 8 | 481 | 9.018e-05 | 0.001315 |
| 320 | NEGATIVE REGULATION OF LIPID METABOLIC PROCESS | 4 | 80 | 9.762e-05 | 0.001419 |
| 321 | REGULATION OF PROTEIN LOCALIZATION | 11 | 950 | 0.0001059 | 0.001535 |
| 322 | REGULATION OF PEPTIDE TRANSPORT | 6 | 256 | 0.0001164 | 0.001682 |
| 323 | MYD88 DEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY | 3 | 32 | 0.0001197 | 0.001724 |
| 324 | POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT | 6 | 258 | 0.0001215 | 0.001745 |
| 325 | POSITIVE REGULATION OF DEVELOPMENTAL PROCESS | 12 | 1142 | 0.0001239 | 0.001774 |
| 326 | POSITIVE REGULATION OF CELL ADHESION | 7 | 376 | 0.0001287 | 0.001837 |
| 327 | PROTEIN COMPLEX SUBUNIT ORGANIZATION | 14 | 1527 | 0.0001325 | 0.001886 |
| 328 | REGULATION OF INTRACELLULAR PROTEIN TRANSPORT | 7 | 381 | 0.0001396 | 0.001981 |
| 329 | NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS | 11 | 983 | 0.0001431 | 0.002024 |
| 330 | POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION | 5 | 167 | 0.0001441 | 0.002025 |
| 331 | PROTEIN KINASE B SIGNALING | 3 | 34 | 0.0001438 | 0.002025 |
| 332 | INTERSPECIES INTERACTION BETWEEN ORGANISMS | 9 | 662 | 0.0001476 | 0.002058 |
| 333 | EPITHELIAL CELL PROLIFERATION | 4 | 89 | 0.0001477 | 0.002058 |
| 334 | SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM | 9 | 662 | 0.0001476 | 0.002058 |
| 335 | INTRACELLULAR RECEPTOR SIGNALING PATHWAY | 5 | 168 | 0.0001482 | 0.002058 |
| 336 | REGULATION OF PROTEIN OLIGOMERIZATION | 3 | 35 | 0.0001569 | 0.002173 |
| 337 | MITOCHONDRIAL MEMBRANE ORGANIZATION | 4 | 92 | 0.0001679 | 0.002318 |
| 338 | GLAND DEVELOPMENT | 7 | 395 | 0.0001743 | 0.0024 |
| 339 | POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT | 6 | 282 | 0.000197 | 0.002692 |
| 340 | SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE | 4 | 96 | 0.0001978 | 0.002692 |
| 341 | LIPID BIOSYNTHETIC PROCESS | 8 | 539 | 0.0001971 | 0.002692 |
| 342 | FEMALE GAMETE GENERATION | 4 | 96 | 0.0001978 | 0.002692 |
| 343 | MACROMOLECULAR COMPLEX ASSEMBLY | 13 | 1398 | 0.0002102 | 0.002852 |
| 344 | REGULATION OF TRANSPORT | 15 | 1804 | 0.000215 | 0.002908 |
| 345 | SPLEEN DEVELOPMENT | 3 | 39 | 0.0002172 | 0.00293 |
| 346 | BIOLOGICAL ADHESION | 11 | 1032 | 0.0002188 | 0.002942 |
| 347 | REGULATION OF MYELOID CELL DIFFERENTIATION | 5 | 183 | 0.0002206 | 0.002959 |
| 348 | CELLULAR RESPONSE TO OXIDATIVE STRESS | 5 | 184 | 0.0002263 | 0.003026 |
| 349 | REGULATION OF GLUCOSE TRANSPORT | 4 | 100 | 0.0002315 | 0.003086 |
| 350 | REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY | 3 | 40 | 0.0002343 | 0.003115 |
| 351 | REGULATION OF LIPID STORAGE | 3 | 41 | 0.0002523 | 0.003345 |
| 352 | CELL DEVELOPMENT | 13 | 1426 | 0.0002555 | 0.003377 |
| 353 | MYELOID CELL DIFFERENTIATION | 5 | 189 | 0.0002562 | 0.003377 |
| 354 | REGULATION OF INTERLEUKIN 6 PRODUCTION | 4 | 104 | 0.000269 | 0.003536 |
| 355 | ORGANOPHOSPHATE METABOLIC PROCESS | 10 | 885 | 0.000276 | 0.003618 |
| 356 | CELLULAR COMPONENT DISASSEMBLY INVOLVED IN EXECUTION PHASE OF APOPTOSIS | 3 | 43 | 0.0002908 | 0.003801 |
| 357 | PROTEIN OLIGOMERIZATION | 7 | 434 | 0.0003092 | 0.004031 |
| 358 | REGULATION OF PROTEIN TARGETING | 6 | 307 | 0.0003108 | 0.00404 |
| 359 | POSITIVE REGULATION OF INTERLEUKIN 8 PRODUCTION | 3 | 45 | 0.000333 | 0.00428 |
| 360 | THYMOCYTE AGGREGATION | 3 | 45 | 0.000333 | 0.00428 |
| 361 | T CELL DIFFERENTIATION IN THYMUS | 3 | 45 | 0.000333 | 0.00428 |
| 362 | REGULATION OF ALCOHOL BIOSYNTHETIC PROCESS | 3 | 45 | 0.000333 | 0.00428 |
| 363 | REGULATION OF HOMEOSTATIC PROCESS | 7 | 447 | 0.0003694 | 0.004722 |
| 364 | POSITIVE REGULATION OF INFLAMMATORY RESPONSE | 4 | 113 | 0.0003692 | 0.004722 |
| 365 | MITOCHONDRION ORGANIZATION | 8 | 594 | 0.0003791 | 0.00482 |
| 366 | RESPONSE TO ANTIBIOTIC | 3 | 47 | 0.0003789 | 0.00482 |
| 367 | REGULATION OF LEUKOCYTE PROLIFERATION | 5 | 206 | 0.0003808 | 0.004827 |
| 368 | REGULATION OF LYMPHOCYTE MEDIATED IMMUNITY | 4 | 114 | 0.0003818 | 0.004827 |
| 369 | REGULATION OF LIPID KINASE ACTIVITY | 3 | 48 | 0.0004033 | 0.005072 |
| 370 | REGULATION OF NF KAPPAB IMPORT INTO NUCLEUS | 3 | 48 | 0.0004033 | 0.005072 |
| 371 | REGULATION OF PEPTIDE SECRETION | 5 | 209 | 0.0004068 | 0.005102 |
| 372 | POSITIVE REGULATION OF PROTEIN SECRETION | 5 | 211 | 0.0004249 | 0.005315 |
| 373 | REGULATION OF STEROID BIOSYNTHETIC PROCESS | 3 | 49 | 0.0004287 | 0.005348 |
| 374 | POSITIVE REGULATION OF HOMEOSTATIC PROCESS | 5 | 216 | 0.0004728 | 0.005875 |
| 375 | REGULATION OF CERAMIDE BIOSYNTHETIC PROCESS | 2 | 11 | 0.0004784 | 0.005875 |
| 376 | POSITIVE REGULATION OF HAIR CYCLE | 2 | 11 | 0.0004784 | 0.005875 |
| 377 | REGULATION OF FEVER GENERATION | 2 | 11 | 0.0004784 | 0.005875 |
| 378 | REGULATION OF B CELL ACTIVATION | 4 | 121 | 0.0004785 | 0.005875 |
| 379 | NEGATIVE REGULATION OF NECROTIC CELL DEATH | 2 | 11 | 0.0004784 | 0.005875 |
| 380 | REGULATION OF INTERLEUKIN 12 PRODUCTION | 3 | 51 | 0.0004825 | 0.005908 |
| 381 | REGULATION OF MITOCHONDRION ORGANIZATION | 5 | 218 | 0.0004931 | 0.006022 |
| 382 | INNATE IMMUNE RESPONSE | 8 | 619 | 0.0004984 | 0.00607 |
| 383 | REGULATION OF ADAPTIVE IMMUNE RESPONSE | 4 | 123 | 0.0005091 | 0.006175 |
| 384 | REGULATION OF T CELL MEDIATED IMMUNITY | 3 | 52 | 0.0005109 | 0.006175 |
| 385 | REGULATION OF LIPID CATABOLIC PROCESS | 3 | 52 | 0.0005109 | 0.006175 |
| 386 | RESPONSE TO GROWTH FACTOR | 7 | 475 | 0.0005311 | 0.006402 |
| 387 | REGULATION OF DNA METABOLIC PROCESS | 6 | 340 | 0.000534 | 0.00642 |
| 388 | CELLULAR RESPONSE TO AMINO ACID STIMULUS | 3 | 53 | 0.0005404 | 0.006481 |
| 389 | REGULATION OF LYMPHOCYTE APOPTOTIC PROCESS | 3 | 54 | 0.000571 | 0.006783 |
| 390 | REGULATION OF CHEMOKINE BIOSYNTHETIC PROCESS | 2 | 12 | 0.0005729 | 0.006783 |
| 391 | REPLICATIVE SENESCENCE | 2 | 12 | 0.0005729 | 0.006783 |
| 392 | POSITIVE REGULATION OF INTERLEUKIN 2 BIOSYNTHETIC PROCESS | 2 | 12 | 0.0005729 | 0.006783 |
| 393 | POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS | 2 | 12 | 0.0005729 | 0.006783 |
| 394 | LIPID METABOLIC PROCESS | 11 | 1158 | 0.0005836 | 0.006893 |
| 395 | REGULATION OF LIPID BIOSYNTHETIC PROCESS | 4 | 128 | 0.0005916 | 0.006951 |
| 396 | REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION | 4 | 128 | 0.0005916 | 0.006951 |
| 397 | NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS | 9 | 801 | 0.0005994 | 0.007025 |
| 398 | NUCLEAR IMPORT | 4 | 129 | 0.0006092 | 0.007122 |
| 399 | NEGATIVE REGULATION OF TRANSFERASE ACTIVITY | 6 | 351 | 0.0006311 | 0.007359 |
| 400 | POSITIVE REGULATION OF LEUKOCYTE DIFFERENTIATION | 4 | 131 | 0.0006454 | 0.007508 |
| 401 | REGULATION OF SPHINGOLIPID BIOSYNTHETIC PROCESS | 2 | 13 | 0.0006758 | 0.00767 |
| 402 | REGULATION OF MEMBRANE LIPID METABOLIC PROCESS | 2 | 13 | 0.0006758 | 0.00767 |
| 403 | POSITIVE REGULATION OF CELL PROLIFERATION | 9 | 814 | 0.0006726 | 0.00767 |
| 404 | POSITIVE REGULATION OF STEROID BIOSYNTHETIC PROCESS | 2 | 13 | 0.0006758 | 0.00767 |
| 405 | B CELL ACTIVATION | 4 | 132 | 0.0006641 | 0.00767 |
| 406 | REGULATION OF HISTONE PHOSPHORYLATION | 2 | 13 | 0.0006758 | 0.00767 |
| 407 | RESPONSE TO COBALT ION | 2 | 13 | 0.0006758 | 0.00767 |
| 408 | APOPTOTIC MITOCHONDRIAL CHANGES | 3 | 57 | 0.0006693 | 0.00767 |
| 409 | PROTEIN AUTOPROCESSING | 2 | 13 | 0.0006758 | 0.00767 |
| 410 | REGULATION OF BICELLULAR TIGHT JUNCTION ASSEMBLY | 2 | 13 | 0.0006758 | 0.00767 |
| 411 | POSITIVE REGULATION OF CELL DIFFERENTIATION | 9 | 823 | 0.0007275 | 0.008237 |
| 412 | ESTABLISHMENT OF PROTEIN LOCALIZATION TO ORGANELLE | 6 | 361 | 0.0007307 | 0.008253 |
| 413 | RESPONSE TO ALCOHOL | 6 | 362 | 0.0007413 | 0.008352 |
| 414 | CELLULAR RESPONSE TO RADIATION | 4 | 137 | 0.0007633 | 0.008579 |
| 415 | REGULATION OF GLUCOSE IMPORT | 3 | 60 | 0.0007778 | 0.008697 |
| 416 | REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING | 4 | 138 | 0.0007844 | 0.008697 |
| 417 | REGULATION OF MONOOXYGENASE ACTIVITY | 3 | 60 | 0.0007778 | 0.008697 |
| 418 | TOLL LIKE RECEPTOR 9 SIGNALING PATHWAY | 2 | 14 | 0.0007869 | 0.008697 |
| 419 | REGULATION OF FIBROBLAST APOPTOTIC PROCESS | 2 | 14 | 0.0007869 | 0.008697 |
| 420 | T CELL MIGRATION | 2 | 14 | 0.0007869 | 0.008697 |
| 421 | DETERMINATION OF ADULT LIFESPAN | 2 | 14 | 0.0007869 | 0.008697 |
| 422 | REGULATION OF PHOSPHOLIPID METABOLIC PROCESS | 3 | 61 | 0.0008163 | 0.008937 |
| 423 | CELLULAR RESPONSE TO HYDROGEN PEROXIDE | 3 | 61 | 0.0008163 | 0.008937 |
| 424 | REGULATION OF INTERLEUKIN 8 PRODUCTION | 3 | 61 | 0.0008163 | 0.008937 |
| 425 | REGULATION OF CELL DEVELOPMENT | 9 | 836 | 0.0008133 | 0.008937 |
| 426 | NEGATIVE REGULATION OF PHOSPHOPROTEIN PHOSPHATASE ACTIVITY | 2 | 15 | 0.0009062 | 0.009671 |
| 427 | REGULATION OF AUTOPHAGY | 5 | 249 | 0.0008983 | 0.009671 |
| 428 | REGULATION OF HEAT GENERATION | 2 | 15 | 0.0009062 | 0.009671 |
| 429 | RESPONSE TO MURAMYL DIPEPTIDE | 2 | 15 | 0.0009062 | 0.009671 |
| 430 | REGULATION OF HAIR FOLLICLE DEVELOPMENT | 2 | 15 | 0.0009062 | 0.009671 |
| 431 | RESPIRATORY BURST | 2 | 15 | 0.0009062 | 0.009671 |
| 432 | NEGATIVE REGULATION OF INTERLEUKIN 12 PRODUCTION | 2 | 15 | 0.0009062 | 0.009671 |
| 433 | APOPTOTIC DNA FRAGMENTATION | 2 | 15 | 0.0009062 | 0.009671 |
| 434 | CHRONIC INFLAMMATORY RESPONSE | 2 | 15 | 0.0009062 | 0.009671 |
| 435 | POSITIVE REGULATION OF MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS | 2 | 15 | 0.0009062 | 0.009671 |
| 436 | REGULATION OF CELL KILLING | 3 | 63 | 0.0008969 | 0.009671 |
| 437 | NEGATIVE REGULATION OF KINASE ACTIVITY | 5 | 250 | 0.0009145 | 0.009738 |
| 438 | RESPONSE TO IONIZING RADIATION | 4 | 145 | 0.0009433 | 0.009998 |
| 439 | REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY | 4 | 145 | 0.0009433 | 0.009998 |
| Num | GO | Overlap | Size | P Value | Adj. P Value |
|---|---|---|---|---|---|
| 1 | TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY BINDING | 9 | 47 | 1.311e-14 | 1.218e-11 |
| 2 | CYTOKINE RECEPTOR BINDING | 13 | 271 | 1.141e-12 | 5.298e-10 |
| 3 | ENZYME BINDING | 25 | 1737 | 6.465e-12 | 2.002e-09 |
| 4 | DEATH RECEPTOR BINDING | 6 | 18 | 1.018e-11 | 2.363e-09 |
| 5 | PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY | 8 | 70 | 3.3e-11 | 6.132e-09 |
| 6 | X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY | 7 | 43 | 4.512e-11 | 6.986e-09 |
| 7 | PHOSPHATIDYLINOSITOL KINASE ACTIVITY | 7 | 51 | 1.591e-10 | 2.112e-08 |
| 8 | UBIQUITIN LIKE PROTEIN LIGASE BINDING | 11 | 264 | 3.331e-10 | 3.868e-08 |
| 9 | PROTEASE BINDING | 8 | 104 | 8.322e-10 | 8.59e-08 |
| 10 | KINASE ACTIVITY | 16 | 842 | 2.225e-09 | 2.067e-07 |
| 11 | DEATH RECEPTOR ACTIVITY | 5 | 24 | 8.338e-09 | 7.042e-07 |
| 12 | PROTEIN HETERODIMERIZATION ACTIVITY | 12 | 468 | 1.184e-08 | 9.168e-07 |
| 13 | TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS | 16 | 992 | 2.269e-08 | 1.622e-06 |
| 14 | TUMOR NECROSIS FACTOR RECEPTOR BINDING | 5 | 30 | 2.757e-08 | 1.83e-06 |
| 15 | CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC PROCESS | 4 | 15 | 9.744e-08 | 6.035e-06 |
| 16 | PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY | 4 | 16 | 1.296e-07 | 7.527e-06 |
| 17 | CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY | 6 | 86 | 2.202e-07 | 1.203e-05 |
| 18 | ENZYME REGULATOR ACTIVITY | 14 | 959 | 6.805e-07 | 3.512e-05 |
| 19 | PROTEIN SERINE THREONINE KINASE ACTIVITY | 10 | 445 | 7.497e-07 | 3.666e-05 |
| 20 | RECEPTOR BINDING | 17 | 1476 | 9.538e-07 | 4.43e-05 |
| 21 | PROTEIN DIMERIZATION ACTIVITY | 15 | 1149 | 1.033e-06 | 4.569e-05 |
| 22 | KINASE REGULATOR ACTIVITY | 7 | 186 | 1.369e-06 | 5.53e-05 |
| 23 | ADENYL NUCLEOTIDE BINDING | 17 | 1514 | 1.357e-06 | 5.53e-05 |
| 24 | MOLECULAR FUNCTION REGULATOR | 16 | 1353 | 1.535e-06 | 5.943e-05 |
| 25 | KINASE BINDING | 11 | 606 | 1.607e-06 | 5.971e-05 |
| 26 | IDENTICAL PROTEIN BINDING | 15 | 1209 | 1.95e-06 | 6.968e-05 |
| 27 | PROTEIN KINASE ACTIVITY | 11 | 640 | 2.723e-06 | 9.369e-05 |
| 28 | INSULIN RECEPTOR SUBSTRATE BINDING | 3 | 11 | 4.163e-06 | 0.0001381 |
| 29 | CYSTEINE TYPE ENDOPEPTIDASE REGULATOR ACTIVITY INVOLVED IN APOPTOTIC PROCESS | 4 | 42 | 7.521e-06 | 0.0002409 |
| 30 | PROTEIN KINASE A CATALYTIC SUBUNIT BINDING | 3 | 15 | 1.138e-05 | 0.0003525 |
| 31 | INTERLEUKIN 1 RECEPTOR BINDING | 3 | 16 | 1.398e-05 | 0.000419 |
| 32 | PROTEIN DOMAIN SPECIFIC BINDING | 10 | 624 | 1.502e-05 | 0.000436 |
| 33 | CYSTEINE TYPE PEPTIDASE ACTIVITY | 6 | 184 | 1.852e-05 | 0.0005215 |
| 34 | RIBONUCLEOTIDE BINDING | 17 | 1860 | 2.149e-05 | 0.0005872 |
| 35 | PROTEIN PHOSPHATASE BINDING | 5 | 120 | 3e-05 | 0.0007964 |
| 36 | CAMP BINDING | 3 | 23 | 4.356e-05 | 0.001124 |
| 37 | PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY | 3 | 30 | 9.837e-05 | 0.00247 |
| 38 | PHOSPHATASE BINDING | 5 | 162 | 0.0001249 | 0.003055 |
| 39 | CYCLIC NUCLEOTIDE BINDING | 3 | 36 | 0.0001708 | 0.004069 |
| 40 | PROTEIN KINASE A BINDING | 3 | 42 | 0.0002711 | 0.006297 |
| Num | GO | Overlap | Size | P Value | Adj. P Value |
|---|---|---|---|---|---|
| 1 | TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS | 14 | 237 | 7.836e-15 | 4.576e-12 |
| 2 | PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX | 7 | 20 | 1.145e-13 | 3.343e-11 |
| 3 | MEMBRANE MICRODOMAIN | 13 | 288 | 2.466e-12 | 4.8e-10 |
| 4 | CATALYTIC COMPLEX | 20 | 1038 | 9.707e-12 | 1.417e-09 |
| 5 | TRANSFERASE COMPLEX | 14 | 703 | 1.499e-08 | 1.751e-06 |
| 6 | MEMBRANE PROTEIN COMPLEX | 15 | 1020 | 2.272e-07 | 2.212e-05 |
| 7 | PROTEIN KINASE COMPLEX | 6 | 90 | 2.889e-07 | 2.41e-05 |
| 8 | CILIARY BASE | 4 | 23 | 6.209e-07 | 4.532e-05 |
| 9 | CYTOSOLIC PART | 7 | 223 | 4.559e-06 | 0.0002959 |
| 10 | EXTRINSIC COMPONENT OF MEMBRANE | 7 | 252 | 1.014e-05 | 0.0005923 |
| 11 | MEMBRANE REGION | 13 | 1134 | 2.492e-05 | 0.001323 |
Over-represented Pathway
| Num | Pathway | Pathview | Overlap | Size | P Value | Adj. P Value |
|---|---|---|---|---|---|---|
| 1 | hsa04210_Apoptosis | 60 | 89 | 1.769e-153 | 3.185e-151 | |
| 2 | hsa04380_Osteoclast_differentiation | 21 | 128 | 9.904e-32 | 8.913e-30 | |
| 3 | hsa04722_Neurotrophin_signaling_pathway | 19 | 127 | 7.243e-28 | 4.346e-26 | |
| 4 | hsa04620_Toll.like_receptor_signaling_pathway | 17 | 102 | 8.537e-26 | 3.842e-24 | |
| 5 | hsa04660_T_cell_receptor_signaling_pathway | 17 | 108 | 2.421e-25 | 8.715e-24 | |
| 6 | hsa04662_B_cell_receptor_signaling_pathway | 15 | 75 | 4.286e-24 | 1.286e-22 | |
| 7 | hsa04650_Natural_killer_cell_mediated_cytotoxicity | 17 | 136 | 1.532e-23 | 3.939e-22 | |
| 8 | hsa04010_MAPK_signaling_pathway | 19 | 268 | 1.712e-21 | 3.852e-20 | |
| 9 | hsa04910_Insulin_signaling_pathway | 15 | 138 | 7.163e-20 | 1.433e-18 | |
| 10 | hsa04370_VEGF_signaling_pathway | 12 | 76 | 4.418e-18 | 7.953e-17 | |
| 11 | hsa04151_PI3K_AKT_signaling_pathway | 18 | 351 | 7.65e-18 | 1.252e-16 | |
| 12 | hsa04062_Chemokine_signaling_pathway | 15 | 189 | 8.948e-18 | 1.342e-16 | |
| 13 | hsa04014_Ras_signaling_pathway | 14 | 236 | 7.389e-15 | 1.023e-13 | |
| 14 | hsa04510_Focal_adhesion | 13 | 200 | 2.311e-14 | 2.971e-13 | |
| 15 | hsa04914_Progesterone.mediated_oocyte_maturation | 10 | 87 | 8.989e-14 | 1.079e-12 | |
| 16 | hsa04621_NOD.like_receptor_signaling_pathway | 9 | 59 | 1.176e-13 | 1.323e-12 | |
| 17 | hsa04920_Adipocytokine_signaling_pathway | 9 | 68 | 4.516e-13 | 4.782e-12 | |
| 18 | hsa04973_Carbohydrate_digestion_and_absorption | 8 | 44 | 6.58e-13 | 6.421e-12 | |
| 19 | hsa04622_RIG.I.like_receptor_signaling_pathway | 9 | 71 | 6.778e-13 | 6.421e-12 | |
| 20 | hsa04664_Fc_epsilon_RI_signaling_pathway | 9 | 79 | 1.839e-12 | 1.655e-11 | |
| 21 | hsa04150_mTOR_signaling_pathway | 8 | 52 | 2.743e-12 | 2.351e-11 | |
| 22 | hsa04012_ErbB_signaling_pathway | 9 | 87 | 4.499e-12 | 3.681e-11 | |
| 23 | hsa04115_p53_signaling_pathway | 8 | 69 | 2.93e-11 | 2.293e-10 | |
| 24 | hsa04960_Aldosterone.regulated_sodium_reabsorption | 7 | 42 | 3.786e-11 | 2.84e-10 | |
| 25 | hsa04666_Fc_gamma_R.mediated_phagocytosis | 8 | 95 | 4.01e-10 | 2.887e-09 | |
| 26 | hsa04630_Jak.STAT_signaling_pathway | 9 | 155 | 8.424e-10 | 5.832e-09 | |
| 27 | hsa04070_Phosphatidylinositol_signaling_system | 7 | 78 | 3.41e-09 | 2.274e-08 | |
| 28 | hsa04623_Cytosolic_DNA.sensing_pathway | 6 | 56 | 1.63e-08 | 1.048e-07 | |
| 29 | hsa04670_Leukocyte_transendothelial_migration | 7 | 117 | 5.847e-08 | 3.629e-07 | |
| 30 | hsa04810_Regulation_of_actin_cytoskeleton | 7 | 214 | 3.475e-06 | 2.085e-05 | |
| 31 | hsa00562_Inositol_phosphate_metabolism | 4 | 57 | 2.567e-05 | 0.000149 | |
| 32 | hsa04720_Long.term_potentiation | 4 | 70 | 5.787e-05 | 0.0003255 | |
| 33 | hsa04310_Wnt_signaling_pathway | 5 | 151 | 8.974e-05 | 0.0004895 | |
| 34 | hsa04640_Hematopoietic_cell_lineage | 4 | 88 | 0.0001414 | 0.0007485 | |
| 35 | hsa04114_Oocyte_meiosis | 4 | 114 | 0.0003818 | 0.001963 | |
| 36 | hsa04020_Calcium_signaling_pathway | 4 | 177 | 0.001965 | 0.009827 | |
| 37 | hsa04962_Vasopressin.regulated_water_reabsorption | 2 | 44 | 0.007722 | 0.03756 | |
| 38 | hsa04742_Taste_transduction | 2 | 52 | 0.01066 | 0.05049 | |
| 39 | hsa04340_Hedgehog_signaling_pathway | 2 | 56 | 0.01228 | 0.0567 | |
| 40 | hsa04141_Protein_processing_in_endoplasmic_reticulum | 3 | 168 | 0.01404 | 0.06318 | |
| 41 | hsa04976_Bile_secretion | 2 | 71 | 0.01926 | 0.08457 | |
| 42 | hsa04971_Gastric_acid_secretion | 2 | 74 | 0.02082 | 0.08922 | |
| 43 | hsa04970_Salivary_secretion | 2 | 89 | 0.02933 | 0.1225 | |
| 44 | hsa04540_Gap_junction | 2 | 90 | 0.02994 | 0.1225 | |
| 45 | hsa04912_GnRH_signaling_pathway | 2 | 101 | 0.03697 | 0.1447 | |
| 46 | hsa04916_Melanogenesis | 2 | 101 | 0.03697 | 0.1447 | |
| 47 | hsa04270_Vascular_smooth_muscle_contraction | 2 | 116 | 0.04747 | 0.1818 | |
| 48 | hsa04110_Cell_cycle | 2 | 128 | 0.05655 | 0.2121 | |
| 49 | hsa04360_Axon_guidance | 2 | 130 | 0.05812 | 0.2135 | |
| 50 | hsa04120_Ubiquitin_mediated_proteolysis | 2 | 139 | 0.06536 | 0.2353 | |
| 51 | hsa04740_Olfactory_transduction | 2 | 388 | 0.325 | 1 |
lncRNA-mediated sponge
| Num | lncRNA | miRNAs | miRNAs count | Gene | Sponge regulatory network | lncRNA log2FC | lncRNA pvalue | Gene log2FC | Gene pvalue | lncRNA-gene Pearson correlation |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | RP11-193H5.1 |
hsa-miR-103a-3p;hsa-miR-125a-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-26b-5p;hsa-miR-29a-5p;hsa-miR-320a;hsa-miR-7-1-3p | 10 | PRKAR2A | Sponge network | -0.426 | 0.01062 | -1.252 | 0 | 0.655 |
| 2 | RAMP2-AS1 | hsa-miR-17-5p;hsa-miR-181b-5p;hsa-miR-205-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-29a-5p;hsa-miR-365a-3p;hsa-miR-455-5p;hsa-miR-7-5p | 12 | BCL2 | Sponge network | -1.258 | 0.00026 | -0.91 | 1.0E-5 | 0.623 |
| 3 | RP1-193H18.2 |
hsa-miR-17-5p;hsa-miR-181b-5p;hsa-miR-205-3p;hsa-miR-20a-3p;hsa-miR-21-5p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-450b-5p;hsa-miR-452-5p;hsa-miR-542-3p;hsa-miR-7-5p | 11 | BCL2 | Sponge network | -1.539 | 0 | -0.91 | 1.0E-5 | 0.62 |
| 4 | ZNF667-AS1 |
hsa-miR-17-5p;hsa-miR-181b-5p;hsa-miR-205-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-224-3p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-452-5p;hsa-miR-590-5p;hsa-miR-7-5p | 12 | BCL2 | Sponge network | -1.395 | 0 | -0.91 | 1.0E-5 | 0.598 |
| 5 | MAGI2-AS3 |
hsa-miR-103a-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-222-3p;hsa-miR-224-3p;hsa-miR-29b-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-424-5p;hsa-miR-429;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 25 | PIK3R1 | Sponge network | -0.939 | 4.0E-5 | -1.219 | 0 | 0.589 |
| 6 | PWAR6 |
hsa-miR-17-5p;hsa-miR-205-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-224-3p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-452-5p;hsa-miR-455-5p;hsa-miR-7-5p | 10 | BCL2 | Sponge network | -1.629 | 0 | -0.91 | 1.0E-5 | 0.509 |
| 7 | PCBP1-AS1 | hsa-miR-181b-5p;hsa-miR-21-5p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-365a-3p;hsa-miR-450b-5p;hsa-miR-452-5p;hsa-miR-455-5p;hsa-miR-542-3p;hsa-miR-7-5p | 10 | BCL2 | Sponge network | -0.746 | 0 | -0.91 | 1.0E-5 | 0.509 |
| 8 | RP11-774O3.3 |
hsa-miR-17-5p;hsa-miR-205-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-365a-3p;hsa-miR-542-3p;hsa-miR-7-5p | 10 | BCL2 | Sponge network | -1.712 | 0 | -0.91 | 1.0E-5 | 0.509 |
| 9 | SNHG14 |
hsa-miR-17-5p;hsa-miR-205-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-365a-3p;hsa-miR-452-5p;hsa-miR-455-5p;hsa-miR-7-5p | 10 | BCL2 | Sponge network | -1.125 | 0.0001 | -0.91 | 1.0E-5 | 0.505 |
| 10 | MAGI2-AS3 |
hsa-miR-141-3p;hsa-miR-188-5p;hsa-miR-200a-3p;hsa-miR-205-5p;hsa-miR-20a-3p;hsa-miR-324-5p;hsa-miR-33a-5p;hsa-miR-429;hsa-miR-452-3p;hsa-miR-501-5p;hsa-miR-589-3p;hsa-miR-708-3p;hsa-miR-92a-3p;hsa-miR-944 | 14 | IRAK3 | Sponge network | -0.939 | 4.0E-5 | -0.224 | 0.27721 | 0.496 |
| 11 | MAGI2-AS3 |
hsa-miR-17-5p;hsa-miR-205-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-224-3p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-29a-5p;hsa-miR-365a-3p;hsa-miR-452-5p;hsa-miR-455-5p;hsa-miR-7-5p | 13 | BCL2 | Sponge network | -0.939 | 4.0E-5 | -0.91 | 1.0E-5 | 0.488 |
| 12 | FGF14-AS2 | hsa-miR-17-5p;hsa-miR-181b-5p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-29a-5p;hsa-miR-452-5p;hsa-miR-7-5p | 10 | BCL2 | Sponge network | -1.914 | 0 | -0.91 | 1.0E-5 | 0.488 |
| 13 | RP11-594N15.3 |
hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-222-3p;hsa-miR-320b;hsa-miR-93-5p | 15 | PIK3R1 | Sponge network | -2.86 | 0 | -1.219 | 0 | 0.483 |
| 14 | SNHG14 |
hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-222-3p;hsa-miR-455-3p;hsa-miR-584-5p;hsa-miR-589-3p;hsa-miR-629-3p | 11 | PIK3R1 | Sponge network | -1.125 | 0.0001 | -1.219 | 0 | 0.482 |
| 15 | AC007743.1 |
hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-222-3p;hsa-miR-424-5p;hsa-miR-584-5p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-629-3p | 13 | PIK3R1 | Sponge network | -1.053 | 0.00923 | -1.219 | 0 | 0.478 |
| 16 | CTA-221G9.11 |
hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-222-3p;hsa-miR-224-3p;hsa-miR-450b-5p;hsa-miR-629-3p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -2.198 | 0 | -1.219 | 0 | 0.477 |
| 17 | RP1-193H18.2 |
hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-222-3p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-455-3p;hsa-miR-584-5p;hsa-miR-589-3p;hsa-miR-96-5p | 11 | PIK3R1 | Sponge network | -1.539 | 0 | -1.219 | 0 | 0.476 |
| 18 | RP11-400K9.4 |
hsa-miR-103a-3p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-20a-5p;hsa-miR-324-3p;hsa-miR-93-5p | 10 | PIK3R1 | Sponge network | -0.304 | 0.38627 | -1.219 | 0 | 0.469 |
| 19 | PWAR6 |
hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-222-3p;hsa-miR-224-3p;hsa-miR-455-3p;hsa-miR-589-3p;hsa-miR-629-3p | 11 | PIK3R1 | Sponge network | -1.629 | 0 | -1.219 | 0 | 0.466 |
| 20 | RP11-815I9.4 | hsa-miR-103a-3p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-222-3p;hsa-miR-29b-3p;hsa-miR-320a;hsa-miR-589-3p;hsa-miR-590-5p | 11 | PIK3R1 | Sponge network | 0.004 | 0.98116 | -1.219 | 0 | 0.464 |
| 21 | CTA-221G9.11 |
hsa-miR-17-5p;hsa-miR-181b-5p;hsa-miR-205-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-224-3p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-29a-5p;hsa-miR-450b-5p | 11 | BCL2 | Sponge network | -2.198 | 0 | -0.91 | 1.0E-5 | 0.461 |
| 22 | RP4-798P15.3 |
hsa-let-7a-3p;hsa-miR-103a-3p;hsa-miR-146b-5p;hsa-miR-155-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-197-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-26b-5p;hsa-miR-29a-5p;hsa-miR-590-5p;hsa-miR-7-1-3p | 13 | PRKAR2A | Sponge network | -1.213 | 0.00098 | -1.252 | 0 | 0.457 |
| 23 | RP11-284N8.3 |
hsa-miR-103a-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-222-3p;hsa-miR-224-3p;hsa-miR-455-3p;hsa-miR-590-5p;hsa-miR-93-5p;hsa-miR-96-5p | 12 | PIK3R1 | Sponge network | 0.003 | 0.99478 | -1.219 | 0 | 0.457 |
| 24 | CTD-2015G9.2 |
hsa-miR-103a-3p;hsa-miR-146b-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-197-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-7-1-3p;hsa-miR-708-3p;hsa-miR-769-3p | 11 | PRKAR2A | Sponge network | -3.112 | 5.0E-5 | -1.252 | 0 | 0.449 |
| 25 | RP11-166D19.1 |
hsa-miR-141-3p;hsa-miR-188-5p;hsa-miR-200a-3p;hsa-miR-205-5p;hsa-miR-20a-3p;hsa-miR-33a-5p;hsa-miR-429;hsa-miR-452-3p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-92a-3p;hsa-miR-944 | 12 | IRAK3 | Sponge network | -0.882 | 5.0E-5 | -0.224 | 0.27721 | 0.448 |
| 26 | BHLHE40-AS1 |
hsa-miR-103a-3p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-222-3p;hsa-miR-450b-5p;hsa-miR-590-5p;hsa-miR-96-5p | 10 | PIK3R1 | Sponge network | -0.932 | 0 | -1.219 | 0 | 0.438 |
| 27 | SH3RF3-AS1 |
hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-222-3p;hsa-miR-29b-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-590-5p | 13 | PIK3R1 | Sponge network | -0.175 | 0.58985 | -1.219 | 0 | 0.435 |
| 28 | ZNF667-AS1 |
hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-222-3p;hsa-miR-224-3p;hsa-miR-424-5p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-96-5p | 14 | PIK3R1 | Sponge network | -1.395 | 0 | -1.219 | 0 | 0.434 |
| 29 | AC007743.1 |
hsa-miR-17-5p;hsa-miR-205-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-29a-5p;hsa-miR-365a-3p;hsa-miR-455-5p;hsa-miR-590-5p;hsa-miR-7-5p | 12 | BCL2 | Sponge network | -1.053 | 0.00923 | -0.91 | 1.0E-5 | 0.429 |
| 30 | RP11-774O3.3 |
hsa-miR-103a-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-222-3p;hsa-miR-320b;hsa-miR-324-3p;hsa-miR-424-5p;hsa-miR-589-3p | 15 | PIK3R1 | Sponge network | -1.712 | 0 | -1.219 | 0 | 0.415 |
| 31 | TPTEP1 |
hsa-miR-17-5p;hsa-miR-181b-5p;hsa-miR-205-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-29a-5p;hsa-miR-365a-3p;hsa-miR-455-5p;hsa-miR-542-3p;hsa-miR-590-5p;hsa-miR-7-5p | 14 | BCL2 | Sponge network | -2.193 | 0 | -0.91 | 1.0E-5 | 0.409 |
| 32 | RP11-166D19.1 |
hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-222-3p;hsa-miR-224-3p;hsa-miR-324-3p;hsa-miR-429;hsa-miR-455-3p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-96-5p | 19 | PIK3R1 | Sponge network | -0.882 | 5.0E-5 | -1.219 | 0 | 0.401 |
| 33 | CTD-2015G9.2 |
hsa-miR-103a-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-222-3p;hsa-miR-450b-5p;hsa-miR-589-3p;hsa-miR-93-5p | 16 | PIK3R1 | Sponge network | -3.112 | 5.0E-5 | -1.219 | 0 | 0.397 |
| 34 | RP11-400K9.4 |
hsa-let-7a-3p;hsa-miR-141-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-339-5p;hsa-miR-362-5p;hsa-miR-93-5p | 13 | PRKACB | Sponge network | -0.304 | 0.38627 | -0.321 | 0.02288 | 0.393 |
| 35 | RP4-798P15.3 |
hsa-miR-103a-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-222-3p;hsa-miR-455-3p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-96-5p | 14 | PIK3R1 | Sponge network | -1.213 | 0.00098 | -1.219 | 0 | 0.393 |
| 36 | LINC00883 | hsa-let-7a-3p;hsa-miR-141-3p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-30d-3p;hsa-miR-532-5p;hsa-miR-944 | 11 | PRKACB | Sponge network | 0.556 | 0.00093 | -0.321 | 0.02288 | 0.392 |
| 37 | MAGI2-AS3 |
hsa-let-7a-3p;hsa-let-7d-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-339-5p;hsa-miR-362-5p;hsa-miR-429;hsa-miR-7-1-3p;hsa-miR-708-3p;hsa-miR-93-5p;hsa-miR-944 | 21 | PRKACB | Sponge network | -0.939 | 4.0E-5 | -0.321 | 0.02288 | 0.386 |
| 38 | CTD-2135D7.5 | hsa-miR-103a-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-185-5p;hsa-miR-21-5p;hsa-miR-222-3p;hsa-miR-224-3p;hsa-miR-450b-5p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-629-3p | 11 | PIK3R1 | Sponge network | -2.579 | 0.0001 | -1.219 | 0 | 0.379 |
| 39 | RP11-594N15.3 |
hsa-let-7a-3p;hsa-let-7d-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-93-5p | 14 | PRKACB | Sponge network | -2.86 | 0 | -0.321 | 0.02288 | 0.377 |
| 40 | LINC00900 |
hsa-miR-103a-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-222-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-424-5p;hsa-miR-455-3p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-93-5p | 19 | PIK3R1 | Sponge network | -1.803 | 0 | -1.219 | 0 | 0.373 |
| 41 | AC003090.1 |
hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-222-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-424-5p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 18 | PIK3R1 | Sponge network | -4.323 | 0 | -1.219 | 0 | 0.369 |
| 42 | RP11-757G1.6 | hsa-miR-103a-3p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-222-3p;hsa-miR-424-5p;hsa-miR-589-3p;hsa-miR-93-5p | 11 | PIK3R1 | Sponge network | -1.346 | 0.00088 | -1.219 | 0 | 0.367 |
| 43 | EMX2OS |
hsa-miR-103a-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-222-3p;hsa-miR-224-3p;hsa-miR-29b-3p;hsa-miR-324-3p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-93-5p | 22 | PIK3R1 | Sponge network | -1.459 | 1.0E-5 | -1.219 | 0 | 0.349 |
| 44 | CTC-205M6.5 | hsa-miR-141-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-34a-5p;hsa-miR-7-1-3p;hsa-miR-96-5p | 10 | PRKACB | Sponge network | 0.381 | 0.01756 | -0.321 | 0.02288 | 0.348 |
| 45 | AC003090.1 |
hsa-miR-17-5p;hsa-miR-205-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-365a-3p;hsa-miR-452-5p;hsa-miR-590-5p | 10 | BCL2 | Sponge network | -4.323 | 0 | -0.91 | 1.0E-5 | 0.347 |
| 46 | CTD-2008P7.9 |
hsa-miR-103a-3p;hsa-miR-125a-5p;hsa-miR-146b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-197-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-29a-5p | 10 | PRKAR2A | Sponge network | -1.202 | 0.00093 | -1.252 | 0 | 0.344 |
| 47 | MIR497HG |
hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-222-3p;hsa-miR-224-3p;hsa-miR-455-3p;hsa-miR-584-5p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-96-5p | 13 | PIK3R1 | Sponge network | -1.263 | 0.00248 | -1.219 | 0 | 0.343 |
| 48 | RP11-403I13.7 | hsa-miR-141-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-362-5p;hsa-miR-590-5p;hsa-miR-96-5p | 10 | PRKACB | Sponge network | 0.214 | 0.38819 | -0.321 | 0.02288 | 0.34 |
| 49 | RASSF8-AS1 | hsa-miR-141-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-429;hsa-miR-944 | 11 | PRKACB | Sponge network | 0.121 | 0.52445 | -0.321 | 0.02288 | 0.338 |
| 50 | LINC00284 |
hsa-miR-103a-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-222-3p;hsa-miR-424-5p;hsa-miR-455-3p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p | 17 | PIK3R1 | Sponge network | -4.159 | 0 | -1.219 | 0 | 0.333 |
| 51 | DNM3OS |
hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-224-3p;hsa-miR-429;hsa-miR-590-5p;hsa-miR-96-5p | 11 | PIK3R1 | Sponge network | 0.932 | 0.00442 | -1.219 | 0 | 0.328 |
| 52 | BHLHE40-AS1 |
hsa-let-7a-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-339-5p;hsa-miR-590-5p;hsa-miR-96-5p | 11 | PRKACB | Sponge network | -0.932 | 0 | -0.321 | 0.02288 | 0.322 |
| 53 | LINC00284 |
hsa-miR-17-5p;hsa-miR-205-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-365a-3p;hsa-miR-455-5p;hsa-miR-542-3p;hsa-miR-590-5p;hsa-miR-7-5p | 12 | BCL2 | Sponge network | -4.159 | 0 | -0.91 | 1.0E-5 | 0.316 |
| 54 | DLGAP1-AS5 | hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-222-3p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-589-3p | 10 | PIK3R1 | Sponge network | -6.207 | 0 | -1.219 | 0 | 0.315 |
| 55 | MAGI2-AS3 |
hsa-let-7a-3p;hsa-miR-103a-3p;hsa-miR-106a-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-197-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-26b-5p;hsa-miR-29a-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-3607-3p;hsa-miR-582-5p;hsa-miR-7-1-3p;hsa-miR-708-3p;hsa-miR-769-3p;hsa-miR-92a-3p | 20 | PRKAR2A | Sponge network | -0.939 | 4.0E-5 | -1.252 | 0 | 0.314 |
| 56 | RP11-35G9.5 | hsa-let-7a-3p;hsa-miR-141-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-96-5p | 12 | PRKACB | Sponge network | -0.33 | 0.08136 | -0.321 | 0.02288 | 0.312 |
| 57 | TPTEP1 |
hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-222-3p;hsa-miR-424-5p;hsa-miR-455-3p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p | 13 | PIK3R1 | Sponge network | -2.193 | 0 | -1.219 | 0 | 0.308 |
| 58 | LINC00957 | hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-222-3p;hsa-miR-424-5p;hsa-miR-450b-5p;hsa-miR-455-3p | 10 | PIK3R1 | Sponge network | -0.677 | 2.0E-5 | -1.219 | 0 | 0.306 |
| 59 | BZRAP1-AS1 | hsa-let-7a-3p;hsa-miR-141-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-339-5p;hsa-miR-944 | 12 | PRKACB | Sponge network | -0.233 | 0.50729 | -0.321 | 0.02288 | 0.299 |
| 60 | RP11-193H5.1 |
hsa-miR-103a-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-20a-5p;hsa-miR-22-5p;hsa-miR-29b-3p;hsa-miR-320a | 11 | PIK3R1 | Sponge network | -0.426 | 0.01062 | -1.219 | 0 | 0.297 |
| 61 | RP11-384L8.1 | hsa-miR-17-5p;hsa-miR-181b-5p;hsa-miR-205-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-29a-5p;hsa-miR-365a-3p;hsa-miR-7-5p | 11 | BCL2 | Sponge network | -1.152 | 0.00016 | -0.91 | 1.0E-5 | 0.296 |
| 62 | LINC00702 |
hsa-miR-103a-3p;hsa-miR-1301-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-222-3p;hsa-miR-224-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-324-3p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-93-5p;hsa-miR-96-5p | 21 | PIK3R1 | Sponge network | -0.573 | 0.0699 | -1.219 | 0 | 0.294 |
| 63 | SH3RF3-AS1 |
hsa-let-7a-3p;hsa-miR-16-5p;hsa-miR-182-5p;hsa-miR-26b-5p;hsa-miR-29a-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-582-5p;hsa-miR-590-5p;hsa-miR-7-1-3p | 10 | PRKAR2A | Sponge network | -0.175 | 0.58985 | -1.252 | 0 | 0.291 |
| 64 | RP11-284N8.3 |
hsa-let-7a-3p;hsa-miR-141-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200c-3p;hsa-miR-590-5p;hsa-miR-93-5p;hsa-miR-944;hsa-miR-96-5p | 14 | PRKACB | Sponge network | 0.003 | 0.99478 | -0.321 | 0.02288 | 0.281 |
| 65 | LINC00900 |
hsa-miR-17-5p;hsa-miR-205-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-365a-3p;hsa-miR-455-5p;hsa-miR-590-5p;hsa-miR-7-5p | 11 | BCL2 | Sponge network | -1.803 | 0 | -0.91 | 1.0E-5 | 0.281 |
| 66 | RP11-166D19.1 |
hsa-let-7a-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-339-5p;hsa-miR-429;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-944;hsa-miR-96-5p | 19 | PRKACB | Sponge network | -0.882 | 5.0E-5 | -0.321 | 0.02288 | 0.279 |
| 67 | RP11-244O19.1 | hsa-miR-141-3p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-30d-3p;hsa-miR-34a-5p;hsa-miR-532-5p;hsa-miR-93-5p | 10 | PRKACB | Sponge network | 0.52 | 0.05156 | -0.321 | 0.02288 | 0.278 |
| 68 | LINC00900 |
hsa-miR-141-3p;hsa-miR-200a-3p;hsa-miR-205-5p;hsa-miR-20a-3p;hsa-miR-324-5p;hsa-miR-33a-5p;hsa-miR-452-3p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-708-3p;hsa-miR-92a-3p | 11 | IRAK3 | Sponge network | -1.803 | 0 | -0.224 | 0.27721 | 0.27 |
| 69 | CTC-297N7.7 |
hsa-miR-103a-3p;hsa-miR-15b-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-224-3p;hsa-miR-589-3p;hsa-miR-629-3p;hsa-miR-96-5p | 11 | PIK3R1 | Sponge network | -1.666 | 0.01558 | -1.219 | 0 | 0.267 |
| 70 | CTD-2554C21.3 | hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-222-3p;hsa-miR-455-3p;hsa-miR-629-3p | 10 | PIK3R1 | Sponge network | -2.118 | 6.0E-5 | -1.219 | 0 | 0.267 |
| 71 | RP11-389C8.2 | hsa-let-7a-3p;hsa-miR-141-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-429;hsa-miR-93-5p;hsa-miR-944 | 15 | PRKACB | Sponge network | 0.187 | 0.31051 | -0.321 | 0.02288 | 0.267 |
| 72 | RP11-456K23.1 |
hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200b-3p;hsa-miR-205-3p;hsa-miR-20a-3p;hsa-miR-26b-3p;hsa-miR-335-3p;hsa-miR-3613-5p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-590-3p | 13 | ENDOD1 | Sponge network | -0.223 | 0.27461 | -0.554 | 0.00014 | 0.254 |
| 73 | SH3RF3-AS1 |
hsa-let-7a-3p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-339-5p;hsa-miR-590-5p;hsa-miR-7-1-3p | 13 | PRKACB | Sponge network | -0.175 | 0.58985 | -0.321 | 0.02288 | 0.254 |
| 74 | LINC00702 |
hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-192-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200b-3p;hsa-miR-205-3p;hsa-miR-20a-3p;hsa-miR-26b-3p;hsa-miR-335-3p;hsa-miR-454-3p;hsa-miR-590-3p | 12 | ENDOD1 | Sponge network | -0.573 | 0.0699 | -0.554 | 0.00014 | 0.252 |