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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-28-5p AAGAB -0.14 0.04976 0.81 0 miRanda -0.26 0 NA
2 hsa-miR-28-5p AATK -0.14 0.04976 0.45 0.00408 miRanda -0.27 0.00027 NA
3 hsa-miR-107 ABCA6 0.68 0 -3.37 0 miRanda -0.73 0 NA
4 hsa-miR-338-3p ABCA6 0.08 0.57514 -3.37 0 miRanda -0.26 0 NA
5 hsa-miR-342-3p ABCA6 1.22 0 -3.37 0 miRanda -0.3 0 NA
6 hsa-miR-590-3p ABCA6 1.27 0 -3.37 0 miRanda -0.59 0 NA
7 hsa-miR-590-5p ABCA6 0.75 0 -3.37 0 miRanda -0.57 0 NA
8 hsa-miR-320b ABCA8 0.41 0.00113 -5.12 0 miRanda -0.61 0 NA
9 hsa-miR-375 ABCA8 2.1 0 -5.12 0 miRanda -0.2 1.0E-5 NA
10 hsa-miR-590-3p ABCA8 1.27 0 -5.12 0 miRanda -1.07 0 NA
11 hsa-miR-28-5p ABCB9 -0.14 0.04976 0.95 0 miRanda -0.26 0 NA
12 hsa-miR-28-5p ABCC5 -0.14 0.04976 0.8 0 miRanda -0.16 0.00553 NA
13 hsa-miR-28-5p ABHD1 -0.14 0.04976 -0.98 0 miRanda -0.3 7.0E-5 NA
14 hsa-miR-28-5p ABLIM3 -0.14 0.04976 -1.88 0 miRanda -0.64 0 NA
15 hsa-miR-28-5p ACACA -0.14 0.04976 -0.22 0.02162 miRanda -0.16 0.00043 NA
16 hsa-miR-107 ACACB 0.68 0 -3.51 0 miRanda -0.42 0 NA
17 hsa-miR-324-5p ACACB 0.21 0.13941 -3.51 0 miRanda -0.34 0 NA
18 hsa-miR-455-5p ACACB 0.28 0.03576 -3.51 0 miRanda -0.22 1.0E-5 NA
19 hsa-miR-28-5p ACAD8 -0.14 0.04976 -0.36 0 miRanda -0.12 0.00017 NA
20 hsa-miR-375 ACADL 2.1 0 -5.19 0 miRanda -0.36 0 NA
21 hsa-miR-28-5p ACAT1 -0.14 0.04976 -0.75 0 miRanda -0.16 0.00027 NA
22 hsa-miR-28-5p ACOX3 -0.14 0.04976 0.2 0.02327 miRanda -0.18 1.0E-5 NA
23 hsa-miR-28-5p ACSF2 -0.14 0.04976 -0.26 0.05489 miRanda -0.31 0 NA
24 hsa-miR-375 ACSL4 2.1 0 -1.48 0 miRanda -0.21 0 NA
25 hsa-miR-107 ACSM5 0.68 0 -3.68 0 miRanda -0.44 0 NA
26 hsa-miR-320b ACSM5 0.41 0.00113 -3.68 0 miRanda -0.32 0 NA
27 hsa-miR-590-3p ACSM5 1.27 0 -3.68 0 miRanda -0.6 0 NA
28 hsa-miR-28-5p ADAMTS13 -0.14 0.04976 0.49 0.00058 miRanda -0.25 0.0002 NA
29 hsa-miR-375 ADAMTS3 2.1 0 -1.85 0 miRanda -0.21 0 NA
30 hsa-miR-28-5p ADCK1 -0.14 0.04976 0.19 0.00451 miRanda -0.12 0.00012 NA
31 hsa-miR-28-5p ADCY1 -0.14 0.04976 -0.05 0.84149 miRanda -0.59 0 NA
32 hsa-miR-375 ADCY3 2.1 0 -0.58 0 miRanda -0.12 0 NA
33 hsa-miR-28-5p ADCY6 -0.14 0.04976 -0.63 0 miRanda -0.32 0 NA
34 hsa-miR-342-3p ADH1B 1.22 0 -7.23 0 miRanda -0.54 2.0E-5 NA
35 hsa-miR-429 ADH1B 2.84 0 -7.23 0 miRanda -1.08 0 NA
36 hsa-miR-590-3p ADH1B 1.27 0 -7.23 0 miRanda -1.26 0 NA
37 hsa-miR-590-3p ADH1C 1.27 0 -5.26 0 miRanda -0.93 0 NA
38 hsa-miR-320b ADIPOQ 0.41 0.00113 -7.2 0 miRanda -0.72 0 NA
39 hsa-miR-330-5p ADIPOQ 0.63 0 -7.2 0 miRanda -1.12 0 NA
40 hsa-miR-339-5p ADIPOQ -0.21 0.06859 -7.2 0 miRanda -0.33 0.03308 NA
41 hsa-miR-429 ADIPOQ 2.84 0 -7.2 0 miRanda -1.06 0 NA
42 hsa-miR-590-3p ADIPOQ 1.27 0 -7.2 0 miRanda -1.2 0 NA
43 hsa-miR-28-5p AFF1 -0.14 0.04976 -0.82 0 miRanda -0.18 2.0E-5 NA
44 hsa-miR-28-5p AFF4 -0.14 0.04976 -0.28 0.00153 miRanda -0.2 0 NA
45 hsa-miR-28-5p AFTPH -0.14 0.04976 0.31 0 miRanda -0.1 0.00074 NA
46 hsa-miR-28-5p AGAP11 -0.14 0.04976 -2.72 0 miRanda -0.31 0.00022 NA
47 hsa-miR-28-5p AGBL4 -0.14 0.04976 -0.14 0.45129 miRanda -0.24 0.00912 NA
48 hsa-miR-155-5p AGTR1 1.1 0 -2.44 0 miRTarBase -0.57 0 22525818 MicroRNA-155 miR-155 is one of the micro RNAs miRNA most consistently involved in neoplastic diseases and it is known to repress the angiotensin II type 1 receptor AGTR1; The aim of the present study was to evaluate the expressions of miR-155 and AGTR1 and to clarify the potential efficacy of anti-miR-155 alone and in combination with AGTR1 blocker losartan in endometrial cancers; Expressions of miR-155 and AGTR1 were evaluated using real-time PCR and immunohistochemistry; miR-155 was over-expressed and AGTR1 was underexpressed in endometrial carcinoma tissues; We checked that abolishing the function of miR-155 and AGTR1 by anti-miR-155 or losartan inhibited cell survival of endometrial carcinoma cells respectively and furthermore combined treatment showed synergistic effects; In this study we characterized the expressions of miR-155 and AGTR1 in endometrial tissues; The combined treatment with anti-miR-155 and losartan has a synergistic antiproliferative effect and an improved understanding is required to clarify whether miR-155 and AGTR1 can be used as a novel therapeutic target in endometrial cancer
49 hsa-miR-28-5p AHNAK -0.14 0.04976 -1.77 0 miRanda -0.27 0 NA
50 hsa-miR-183-5p AKAP12 2.96 0 -2.76 0 miRTarBase -0.54 0 NA
51 hsa-miR-375 AKAP6 2.1 0 -2.28 0 miRanda -0.11 0 NA
52 hsa-miR-375 AKAP7 2.1 0 -1.02 0 miRanda -0.11 0 NA
53 hsa-miR-28-5p AKR7A2 -0.14 0.04976 0.34 1.0E-5 miRanda -0.24 0 NA
54 hsa-miR-15a-5p AKT3 0.81 0 -1.39 0 miRTarBase -0.51 0 NA
55 hsa-miR-107 ALB 0.68 0 -3.87 0 miRanda -0.72 0 NA
56 hsa-miR-193a-3p ALB 0.31 0.00478 -3.87 0 miRanda -0.39 0.00094 NA
57 hsa-miR-320b ALB 0.41 0.00113 -3.87 0 miRanda -0.46 1.0E-5 NA
58 hsa-miR-339-5p ALB -0.21 0.06859 -3.87 0 miRanda -0.27 0.01599 NA
59 hsa-miR-590-3p ALB 1.27 0 -3.87 0 miRanda -0.74 0 NA
60 hsa-miR-107 ALDH1A2 0.68 0 -3.85 0 miRanda -0.75 0 NA
61 hsa-miR-142-3p ALDH1A2 1.54 0 -3.85 0 miRanda -0.24 0 NA
62 hsa-miR-330-5p ALDH1A2 0.63 0 -3.85 0 miRanda -0.68 0 NA
63 hsa-miR-338-3p ALDH1A2 0.08 0.57514 -3.85 0 miRanda -0.23 0.0001 NA
64 hsa-miR-28-5p ALDH3A2 -0.14 0.04976 -0.86 0 miRanda -0.29 0 NA
65 hsa-miR-146b-5p AMIGO2 0.63 0 -1.58 0 miRanda -0.11 0.03887 NA
66 hsa-miR-28-5p AMIGO2 -0.14 0.04976 -1.58 0 miRanda -0.24 0.00784 NA
67 hsa-miR-330-5p AMIGO2 0.63 0 -1.58 0 miRanda -0.23 0.00016 NA
68 hsa-miR-361-5p AMIGO2 -0.1 0.09543 -1.58 0 miRanda -0.3 0.00637 NA
69 hsa-miR-28-5p AMPH -0.14 0.04976 -0.23 0.25767 miRanda -0.38 8.0E-5 NA
70 hsa-miR-28-5p AMZ1 -0.14 0.04976 2.49 0 miRanda -0.45 0.00014 NA
71 hsa-miR-28-5p ANGEL1 -0.14 0.04976 -0.24 5.0E-5 miRanda -0.14 0 NA
72 hsa-miR-21-5p ANKRD46 2.32 0 -0.46 0 miRTarBase -0.31 0 21219636 Knockdown of miR-21 significantly increased the expression of ANKRD46 at both mRNA and protein levels; ANKRD46 is newly identified as a direct target of miR-21 in BC
73 hsa-miR-28-5p ANKS1B -0.14 0.04976 0.2 0.2194 miRanda -0.42 0 NA
74 hsa-miR-28-5p ANKS3 -0.14 0.04976 0.72 0 miRanda -0.16 0.0011 NA
75 hsa-miR-375 ANO4 2.1 0 -1.89 0 miRanda -0.13 0 NA
76 hsa-miR-28-5p ANXA9 -0.14 0.04976 1.78 0 miRanda -1.05 0 NA
77 hsa-miR-28-5p AP2A2 -0.14 0.04976 0.03 0.55943 miRanda -0.12 0 NA
78 hsa-miR-28-5p AP2B1 -0.14 0.04976 0.26 0.00183 miRanda -0.22 0 NA
79 hsa-miR-375 APBB1IP 2.1 0 -1.19 0 miRanda -0.13 0 NA
80 hsa-miR-155-5p APC 1.1 0 -0.69 0 miRTarBase -0.15 0 23796566 Upregulated miR 155 in papillary thyroid carcinoma promotes tumor growth by targeting APC and activating Wnt/β catenin signaling; We have searched for miR-155 targets and identified the hypothesis that miR-155 could promote tumor growth of PTC by targeted regulation of adenomatous polyposis coli APC expression and activating the Wnt/β-catenin signaling; Further studies revealed that APC is a novel miR-155 target because miR-155 bound directly to its 3'-untranslated region and reduced both the mRNA and protein levels of APC; Similar to the miR-155 over-expression APC downregulation promoted cell growth whereas rescued APC expression reversed the promotive effect of miR-155; By targeting APC miR-155 efficiently regulates the Wnt/β-catenin signaling
81 hsa-miR-375 APLF 2.1 0 -0.95 0 miRanda -0.15 0 NA
82 hsa-miR-375 APOB 2.1 0 -5.96 0 miRanda -0.29 0 NA
83 hsa-miR-142-3p APOD 1.54 0 -3.12 0 miRanda -0.24 0 NA
84 hsa-miR-375 AQP4 2.1 0 -2.95 0 miRanda -0.17 0 NA
85 hsa-miR-28-5p ARAF -0.14 0.04976 0.24 1.0E-5 miRanda -0.11 4.0E-5 NA
86 hsa-miR-107 AREG 0.68 0 -0.78 0.00739 miRanda -0.41 0.00063 NA
87 hsa-miR-330-5p AREG 0.63 0 -0.78 0.00739 miRanda -0.34 0.00033 NA
88 hsa-miR-590-3p AREG 1.27 0 -0.78 0.00739 miRanda -0.41 0 NA
89 hsa-miR-28-5p ARHGAP32 -0.14 0.04976 0.43 9.0E-5 miRanda -0.36 0 NA
90 hsa-miR-28-5p ARHGAP8 -0.14 0.04976 1.29 0 miRanda -0.12 0.04559 NA
91 hsa-miR-28-5p ARHGEF16 -0.14 0.04976 1.35 0 miRanda -0.31 0 NA
92 hsa-miR-155-5p ARID2 1.1 0 0.01 0.8705 miRTarBase -0.13 0 27035278 MicroRNA 155 promotes tumor growth of human hepatocellular carcinoma by targeting ARID2
93 hsa-miR-28-5p ARL17A -0.14 0.04976 -0.08 0.37677 miRanda -0.12 0.00459 NA
94 hsa-miR-429 ARL4A 2.84 0 -1.62 0 miRanda -0.18 0 NA
95 hsa-miR-28-5p ARL6IP4 -0.14 0.04976 0.5 0 miRanda -0.19 0.00019 NA
96 hsa-miR-28-5p ARMC5 -0.14 0.04976 0.67 0 miRanda -0.28 0 NA
97 hsa-miR-28-5p ARMC7 -0.14 0.04976 0.79 0 miRanda -0.13 0.00026 NA
98 hsa-miR-28-5p ARMC9 -0.14 0.04976 1.05 0 miRanda -0.18 0 NA
99 hsa-miR-28-5p ASB8 -0.14 0.04976 -0.21 0.00012 miRanda -0.19 0 NA
100 hsa-miR-28-5p ATPAF1 -0.14 0.04976 -0.16 0.00532 miRanda -0.12 1.0E-5 NA
101 hsa-miR-28-5p ATRNL1 -0.14 0.04976 -0.74 0.02081 miRanda -0.53 0.00049 NA
102 hsa-miR-375 AVPR1A 2.1 0 -2.1 0 miRanda -0.11 5.0E-5 NA
103 hsa-miR-15b-5p AXIN2 0.79 0 -0.9 0 miRTarBase -0.25 0 NA
104 hsa-miR-28-5p B3GALT4 -0.14 0.04976 0.46 1.0E-5 miRanda -0.14 0.00301 NA
105 hsa-miR-28-5p BAG1 -0.14 0.04976 0.42 2.0E-5 miRanda -0.31 0 NA
106 hsa-miR-375 BAHCC1 2.1 0 -0.35 0.00682 miRanda -0.11 0 NA
107 hsa-miR-107 BBOX1 0.68 0 -3.62 0 miRanda -0.81 0 NA
108 hsa-miR-342-3p BBOX1 1.22 0 -3.62 0 miRanda -0.84 0 NA
109 hsa-miR-28-5p BBS1 -0.14 0.04976 -0.09 0.27359 miRanda -0.29 0 NA
110 hsa-miR-28-5p BCAM -0.14 0.04976 0.51 0.00081 miRanda -0.64 0 NA
111 hsa-miR-375 BCL11B 2.1 0 -0.26 0.19747 miRanda -0.16 0 NA
112 hsa-miR-148a-3p BCL2 0.71 0 -0.9 0 miRTarBase -0.22 0 21455217; 23975374 MiR 148a promotes apoptosis by targeting Bcl 2 in colorectal cancer;MiR 148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl 2; Using western blot and luciferase activity assay CCKBR and Bcl-2 were identified as targets of miR-148a; Moreover we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a
113 hsa-miR-15a-5p BCL2 0.81 0 -0.9 0 miRTarBase -0.39 0 25594541; 22335947; 26915294; 18931683; 25623762 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells
114 hsa-miR-15b-5p BCL2 0.79 0 -0.9 0 miRTarBase -0.28 0 25594541; 26915294; 26884837; 18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2
115 hsa-miR-21-5p BCL2 2.32 0 -0.9 0 miRTarBase -0.49 0 26555418; 21468550; 25994220; 25381586; 23359184; 22964582; 21376256 The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells
116 hsa-miR-375 BCL2L14 2.1 0 -0.13 0.58205 miRanda -0.16 0 NA
117 hsa-miR-155-5p BCL6 1.1 0 -1.26 0 miRTarBase -0.1 3.0E-5 23169640 We show that Bcl6 is indirectly regulated by miR-155 through Mxd1/Mad1 up-regulation; Interestingly we found that miR-155 directly targets HDAC4 a corepressor partner of BCL6; Meta-analysis of the diffuse large B-cell lymphoma patient microarray data showed that miR-155 expression is inversely correlated with Bcl6 and Hdac4; Hence this study provides a better understanding of how miR-155 causes disruption of the BCL6 transcriptional machinery that leads to up-regulation of the survival and proliferation genes in miR-155-induced leukemias
118 hsa-miR-375 BEND6 2.1 0 0.6 2.0E-5 miRanda -0.13 0 NA
119 hsa-miR-28-5p BHLHE40 -0.14 0.04976 0.41 0.00047 miRanda -0.47 0 NA
120 hsa-miR-15a-5p BMI1 0.81 0 0.32 0.00051 miRTarBase -0.11 0.00226 27596816 Our results suggest that overexpression of miR-15a and miR-16 mediates down-regulation of BMI1 and leads to mitochondrial mediated apoptosis
121 hsa-miR-21-5p BMPR2 2.32 0 -0.62 0 miRTarBase -0.22 0 NA
122 hsa-miR-155-5p BRPF3 1.1 0 0.09 0.20587 miRTarBase -0.1 0 NA
123 hsa-miR-21-5p BTG2 2.32 0 -0.81 0 miRTarBase -0.27 0 24821435 miR 21 regulates N methyl N nitro N' nitrosoguanidine induced gastric tumorigenesis by targeting FASLG and BTG2
124 hsa-miR-28-5p BTRC -0.14 0.04976 0.12 0.15929 miRanda -0.25 0 NA
125 hsa-miR-193a-3p C7 0.31 0.00478 -3.46 0 miRanda -0.72 0 NA
126 hsa-miR-330-5p C7 0.63 0 -3.46 0 miRanda -0.79 0 NA
127 hsa-miR-375 C7 2.1 0 -3.46 0 miRanda -0.16 0.00108 NA
128 hsa-miR-590-3p C7 1.27 0 -3.46 0 miRanda -0.79 0 NA
129 hsa-miR-590-5p C7 0.75 0 -3.46 0 miRanda -0.87 0 NA
130 hsa-miR-361-5p CAB39L -0.1 0.09543 -1.42 0 miRanda -0.33 0 NA
131 hsa-miR-542-3p CAB39L 0.57 0 -1.42 0 miRanda -0.12 0.00057 NA
132 hsa-miR-590-3p CAB39L 1.27 0 -1.42 0 miRanda -0.29 0 NA
133 hsa-miR-590-5p CAB39L 0.75 0 -1.42 0 miRanda -0.27 0 NA
134 hsa-miR-28-5p CACNG4 -0.14 0.04976 2.21 0 miRanda -0.63 2.0E-5 NA
135 hsa-miR-15a-5p CADM1 0.81 0 -0.07 0.58588 miRTarBase -0.2 4.0E-5 NA
136 hsa-miR-28-5p CALCOCO1 -0.14 0.04976 -1.08 0 miRanda -0.14 8.0E-5 NA
137 hsa-miR-28-5p CALCOCO2 -0.14 0.04976 -0.44 0 miRanda -0.2 0 NA
138 hsa-miR-28-5p CANT1 -0.14 0.04976 1.19 0 miRanda -0.31 0 NA
139 hsa-miR-324-5p CAPN6 0.21 0.13941 -3.62 0 miRanda -0.18 0.03887 NA
140 hsa-miR-330-5p CAPN6 0.63 0 -3.62 0 miRanda -0.31 0.007 NA
141 hsa-miR-429 CAPN6 2.84 0 -3.62 0 miRanda -0.42 0 NA
142 hsa-miR-28-5p CASC2 -0.14 0.04976 -0.06 0.56145 miRanda -0.21 1.0E-5 NA
143 hsa-miR-103a-3p CAV1 0.61 0 -3.35 0 miRTarBase -0.52 0 NA
144 hsa-miR-142-3p CAV1 1.54 0 -3.35 0 miRanda -0.24 0 NA
145 hsa-miR-320b CAV1 0.41 0.00113 -3.35 0 miRanda -0.21 0 NA
146 hsa-miR-342-3p CAV1 1.22 0 -3.35 0 miRanda -0.37 0 NA
147 hsa-miR-28-5p CCDC113 -0.14 0.04976 0.15 0.13693 miRanda -0.15 0.0019 NA
148 hsa-miR-28-5p CCDC114 -0.14 0.04976 1.17 0 miRanda -0.3 0.00046 NA
149 hsa-miR-375 CCDC129 2.1 0 -2.66 0 miRanda -0.28 0 NA
150 hsa-miR-375 CCDC80 2.1 0 -1.64 0 miRanda -0.16 0 NA
NumGOOverlapSizeP ValueAdj. P Value
1 RESPONSE TO ENDOGENOUS STIMULUS 115 1450 1.013e-13 3.016e-10
2 REGULATION OF CELL DIFFERENTIATION 117 1492 1.296e-13 3.016e-10
3 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 94 1142 3.097e-12 4.804e-09
4 REGULATION OF CELL PROLIFERATION 111 1496 2.017e-11 2.347e-08
5 RESPONSE TO HORMONE 77 893 3.861e-11 3.593e-08
6 MUSCLE STRUCTURE DEVELOPMENT 48 432 5.885e-11 4.564e-08
7 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 118 1672 1.026e-10 6.818e-08
8 RESPONSE TO ORGANIC CYCLIC COMPOUND 77 917 1.358e-10 7.899e-08
9 NEUROGENESIS 103 1402 2.094e-10 9.373e-08
10 CARDIOVASCULAR SYSTEM DEVELOPMENT 69 788 2.216e-10 9.373e-08
11 CIRCULATORY SYSTEM DEVELOPMENT 69 788 2.216e-10 9.373e-08
12 RESPONSE TO LIPID 74 888 4.5e-10 1.745e-07
13 RESPONSE TO OXYGEN CONTAINING COMPOUND 100 1381 8.727e-10 3.123e-07
14 TISSUE DEVELOPMENT 107 1518 9.462e-10 3.145e-07
15 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 61 689 1.706e-09 5.292e-07
16 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 79 1008 1.933e-09 5.622e-07
17 RESPONSE TO ESTRADIOL 24 146 2.074e-09 5.677e-07
18 RESPONSE TO STEROID HORMONE 49 497 2.275e-09 5.882e-07
19 RESPONSE TO ALCOHOL 40 362 2.816e-09 6.553e-07
20 REGULATION OF CELL DEVELOPMENT 69 836 2.709e-09 6.553e-07
21 POSITIVE REGULATION OF CELL DIFFERENTIATION 68 823 3.405e-09 7.544e-07
22 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 121 1848 5.589e-09 1.182e-06
23 RESPONSE TO ESTROGEN 29 218 7.152e-09 1.447e-06
24 RESPONSE TO NITROGEN COMPOUND 69 859 8.213e-09 1.585e-06
25 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 19 100 8.515e-09 1.585e-06
26 CENTRAL NERVOUS SYSTEM DEVELOPMENT 69 872 1.5e-08 2.685e-06
27 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 62 750 1.705e-08 2.886e-06
28 RESPONSE TO OXYGEN LEVELS 35 311 1.737e-08 2.886e-06
29 REGULATION OF CELLULAR COMPONENT MOVEMENT 63 771 2.011e-08 3.226e-06
30 VASCULATURE DEVELOPMENT 45 469 2.365e-08 3.668e-06
31 RESPONSE TO ACID CHEMICAL 35 319 3.314e-08 4.974e-06
32 NEGATIVE REGULATION OF CELL PROLIFERATION 55 643 3.618e-08 5.26e-06
33 ORGAN GROWTH 15 68 3.876e-08 5.465e-06
34 REGULATION OF PHOSPHORUS METABOLIC PROCESS 106 1618 5.617e-08 7.687e-06
35 REGULATION OF LIPID METABOLIC PROCESS 32 282 5.85e-08 7.778e-06
36 REGULATION OF EPITHELIAL CELL PROLIFERATION 32 285 7.498e-08 9.692e-06
37 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 21 138 8.355e-08 1.051e-05
38 ORGAN MORPHOGENESIS 65 841 9.62e-08 1.129e-05
39 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 94 1395 9.702e-08 1.129e-05
40 GLAND DEVELOPMENT 39 395 9.689e-08 1.129e-05
41 MUSCLE ORGAN DEVELOPMENT 31 277 1.289e-07 1.463e-05
42 POSITIVE REGULATION OF CELL PROLIFERATION 63 814 1.456e-07 1.55e-05
43 AGING 30 264 1.467e-07 1.55e-05
44 PROTEIN PHOSPHORYLATION 70 944 1.499e-07 1.55e-05
45 HEART DEVELOPMENT 43 466 1.467e-07 1.55e-05
46 TUBE DEVELOPMENT 48 552 1.676e-07 1.666e-05
47 HEAD DEVELOPMENT 57 709 1.683e-07 1.666e-05
48 RESPONSE TO GROWTH FACTOR 43 475 2.491e-07 2.415e-05
49 REGULATION OF NEURON DIFFERENTIATION 47 554 4.609e-07 4.377e-05
50 CELL DEVELOPMENT 93 1426 4.968e-07 4.623e-05
51 FOREBRAIN DEVELOPMENT 35 357 5.197e-07 4.742e-05
52 REGULATION OF CELL DEATH 95 1472 5.89e-07 5.271e-05
53 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 72 1021 6.685e-07 5.869e-05
54 NEGATIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 10 36 7.416e-07 6.39e-05
55 DEVELOPMENTAL GROWTH 33 333 8.613e-07 7.287e-05
56 RESPONSE TO ABIOTIC STIMULUS 71 1024 1.482e-06 0.0001232
57 RESPONSE TO EXTERNAL STIMULUS 110 1821 1.745e-06 0.0001425
58 UROGENITAL SYSTEM DEVELOPMENT 30 299 2.088e-06 0.0001675
59 BLOOD VESSEL MORPHOGENESIS 34 364 2.254e-06 0.0001778
60 CELLULAR RESPONSE TO HORMONE STIMULUS 45 552 2.378e-06 0.0001821
61 RESPONSE TO KETONE 22 182 2.388e-06 0.0001821
62 HEMIDESMOSOME ASSEMBLY 6 12 2.531e-06 0.0001899
63 REGULATION OF PROTEIN MODIFICATION PROCESS 104 1710 2.574e-06 0.0001901
64 SINGLE ORGANISM BEHAVIOR 35 384 2.796e-06 0.0002033
65 EXTRACELLULAR STRUCTURE ORGANIZATION 30 304 2.932e-06 0.0002099
66 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 19 144 3.143e-06 0.0002206
67 NEGATIVE REGULATION OF CELL DEATH 62 872 3.177e-06 0.0002206
68 MUSCLE TISSUE DEVELOPMENT 28 275 3.418e-06 0.0002272
69 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 108 1805 3.401e-06 0.0002272
70 RESPONSE TO PURINE CONTAINING COMPOUND 20 158 3.34e-06 0.0002272
71 REGULATION OF GROWTH 49 633 3.652e-06 0.0002393
72 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 12 62 3.877e-06 0.0002505
73 RESPONSE TO EXTRACELLULAR STIMULUS 38 441 4.044e-06 0.0002578
74 GLAND MORPHOGENESIS 15 97 4.752e-06 0.0002909
75 POSITIVE REGULATION OF GENE EXPRESSION 104 1733 4.652e-06 0.0002909
76 DIGESTIVE SYSTEM DEVELOPMENT 19 148 4.737e-06 0.0002909
77 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 41 498 5.247e-06 0.0003165
78 RESPONSE TO NUTRIENT 22 191 5.305e-06 0.0003165
79 EPITHELIUM DEVELOPMENT 65 945 5.455e-06 0.0003213
80 COGNITION 26 251 5.549e-06 0.0003227
81 POSITIVE REGULATION OF CATALYTIC ACTIVITY 93 1518 6.927e-06 0.0003864
82 POSITIVE REGULATION OF MOLECULAR FUNCTION 106 1791 6.87e-06 0.0003864
83 CONNECTIVE TISSUE DEVELOPMENT 22 194 6.837e-06 0.0003864
84 POSITIVE REGULATION OF GLUCOSE METABOLIC PROCESS 9 36 6.976e-06 0.0003864
85 NEGATIVE REGULATION OF CELL COMMUNICATION 77 1192 7.316e-06 0.0004005
86 VASCULAR ENDOTHELIAL GROWTH FACTOR SIGNALING PATHWAY 6 14 7.693e-06 0.0004162
87 POSITIVE REGULATION OF LOCOMOTION 36 420 8.122e-06 0.0004344
88 RESPONSE TO PEPTIDE 35 404 8.592e-06 0.0004543
89 RESPONSE TO WOUNDING 44 563 9.025e-06 0.0004718
90 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 99 1656 9.507e-06 0.0004909
91 TELENCEPHALON DEVELOPMENT 24 228 9.609e-06 0.0004909
92 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 105 1784 9.706e-06 0.0004909
93 RESPONSE TO CYTOKINE 52 714 1.043e-05 0.0005216
94 REGULATION OF HYDROLASE ACTIVITY 83 1327 1.061e-05 0.0005253
95 RESPONSE TO INORGANIC SUBSTANCE 39 479 1.148e-05 0.0005623
96 PHOSPHORYLATION 78 1228 1.162e-05 0.0005632
97 GROWTH 35 410 1.181e-05 0.0005665
98 LEARNING 17 131 1.283e-05 0.0006092
99 BIOLOGICAL ADHESION 68 1032 1.364e-05 0.0006413
100 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 80 1275 1.384e-05 0.0006442
101 RESPONSE TO DRUG 36 431 1.431e-05 0.0006594
102 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 56 799 1.455e-05 0.0006636
103 SECOND MESSENGER MEDIATED SIGNALING 19 160 1.481e-05 0.0006692
104 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 68 1036 1.545e-05 0.0006794
105 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 68 1036 1.545e-05 0.0006794
106 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 56 801 1.562e-05 0.0006794
107 RHYTHMIC PROCESS 28 298 1.561e-05 0.0006794
108 REGULATION OF GLUCOSE IMPORT 11 60 1.685e-05 0.000726
109 MAMMARY GLAND MORPHOGENESIS 9 40 1.763e-05 0.000739
110 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 9 40 1.763e-05 0.000739
111 RESPONSE TO FATTY ACID 13 83 1.758e-05 0.000739
112 CELL SUBSTRATE JUNCTION ASSEMBLY 9 41 2.182e-05 0.0009063
113 REGULATION OF ORGAN GROWTH 12 73 2.233e-05 0.0009193
114 RESPONSE TO MECHANICAL STIMULUS 22 210 2.406e-05 0.000982
115 HOMEOSTATIC PROCESS 82 1337 2.437e-05 0.0009861
116 CHEMICAL HOMEOSTASIS 59 874 2.585e-05 0.001034
117 SECRETION 44 588 2.619e-05 0.001034
118 LOCOMOTION 71 1114 2.623e-05 0.001034
119 INTRACELLULAR SIGNAL TRANSDUCTION 93 1572 2.725e-05 0.001057
120 CELL FATE COMMITMENT 23 227 2.708e-05 0.001057
121 VESICLE MEDIATED TRANSPORT 77 1239 2.809e-05 0.00108
122 ARTERY DEVELOPMENT 12 75 2.955e-05 0.001127
123 POSITIVE REGULATION OF PHOSPHOLIPASE ACTIVITY 10 53 3.132e-05 0.001185
124 REGULATION OF PHOSPHOLIPASE ACTIVITY 11 64 3.175e-05 0.001192
125 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 26 278 3.366e-05 0.001243
126 REGULATION OF STEM CELL PROLIFERATION 13 88 3.34e-05 0.001243
127 POSITIVE REGULATION OF RESPONSE TO STIMULUS 109 1929 3.708e-05 0.001303
128 POSITIVE REGULATION OF HYDROLASE ACTIVITY 60 905 3.723e-05 0.001303
129 REGULATION OF MESENCHYMAL CELL PROLIFERATION 8 34 3.667e-05 0.001303
130 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 41 541 3.687e-05 0.001303
131 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 16 128 3.662e-05 0.001303
132 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 65 1004 3.638e-05 0.001303
133 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 41 541 3.687e-05 0.001303
134 REGULATION OF SYSTEM PROCESS 39 507 4.108e-05 0.001426
135 POSITIVE REGULATION OF CELL DEVELOPMENT 37 472 4.328e-05 0.001492
136 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 82 1360 4.423e-05 0.001513
137 SKELETAL SYSTEM DEVELOPMENT 36 455 4.518e-05 0.001534
138 MAMMARY GLAND DEVELOPMENT 15 117 4.728e-05 0.001594
139 REGULATION OF KINASE ACTIVITY 53 776 4.918e-05 0.001646
140 CELLULAR RESPONSE TO ACID CHEMICAL 19 175 5.212e-05 0.001708
141 POSITIVE REGULATION OF CELL DEATH 44 605 5.145e-05 0.001708
142 MESENCHYME DEVELOPMENT 20 190 5.2e-05 0.001708
143 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 62 957 5.413e-05 0.001761
144 REGENERATION 18 161 5.542e-05 0.001791
145 RESPONSE TO CORTICOSTEROID 19 176 5.635e-05 0.001808
146 CARTILAGE DEVELOPMENT 17 147 5.776e-05 0.001841
147 FIBRIL ORGANIZATION 6 19 5.884e-05 0.001862
148 REGULATION OF GLUCOSE METABOLIC PROCESS 14 106 6.03e-05 0.001883
149 NEGATIVE REGULATION OF CELL DIFFERENTIATION 44 609 5.998e-05 0.001883
150 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 63 983 6.445e-05 0.001999
151 LIPID MODIFICATION 21 210 7.229e-05 0.002228
152 REGULATION OF MACROPHAGE DERIVED FOAM CELL DIFFERENTIATION 7 28 7.47e-05 0.002236
153 MUSCLE HYPERTROPHY 7 28 7.47e-05 0.002236
154 REGULATION OF FATTY ACID OXIDATION 7 28 7.47e-05 0.002236
155 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 11 70 7.48e-05 0.002236
156 REGULATION OF MUSCLE SYSTEM PROCESS 20 195 7.496e-05 0.002236
157 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 71 1152 7.555e-05 0.002239
158 SECRETION BY CELL 37 486 7.962e-05 0.002345
159 MELANOCYTE DIFFERENTIATION 6 20 8.131e-05 0.002379
160 REGULATION OF LIPID KINASE ACTIVITY 9 48 8.191e-05 0.002382
161 HEART MORPHOGENESIS 21 212 8.286e-05 0.002395
162 LIPOPROTEIN TRANSPORT 5 13 8.615e-05 0.002444
163 LIPOPROTEIN LOCALIZATION 5 13 8.615e-05 0.002444
164 REGULATION OF CHOLESTEROL STORAGE 5 13 8.615e-05 0.002444
165 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 22 229 8.934e-05 0.002519
166 NEURON DIFFERENTIATION 57 874 9.082e-05 0.002546
167 CELL MOTILITY 55 835 9.317e-05 0.002581
168 LOCALIZATION OF CELL 55 835 9.317e-05 0.002581
169 REGULATION OF SMOOTH MUSCLE CONTRACTION 10 60 9.48e-05 0.00261
170 REGULATION OF SMOOTH MUSCLE CELL MIGRATION 9 49 9.693e-05 0.002637
171 PATTERN SPECIFICATION PROCESS 33 418 9.666e-05 0.002637
172 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 17 154 0.0001036 0.002802
173 REGULATION OF PHOSPHOLIPASE C ACTIVITY 8 39 0.0001047 0.002809
174 REGULATION OF TRANSPORT 101 1804 0.0001051 0.002809
175 CELLULAR COMPONENT MORPHOGENESIS 58 900 0.0001087 0.002889
176 CELLULAR RESPONSE TO LIPID 35 457 0.0001096 0.002899
177 RESPONSE TO METAL ION 28 333 0.0001119 0.002941
178 NEGATIVE REGULATION OF CELL MATRIX ADHESION 7 30 0.00012 0.00312
179 POSITIVE REGULATION OF SMOOTH MUSCLE CELL MIGRATION 7 30 0.00012 0.00312
180 REGULATION OF FATTY ACID METABOLIC PROCESS 12 87 0.0001312 0.003392
181 ARTERY MORPHOGENESIS 9 51 0.0001339 0.003443
182 REGULATION OF NEURON PROJECTION DEVELOPMENT 32 408 0.0001384 0.003538
183 REGULATION OF CELL SUBSTRATE ADHESION 18 173 0.0001407 0.003578
184 REGULATION OF LIPID STORAGE 8 41 0.0001518 0.003839
185 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 35 465 0.0001536 0.003863
186 NEGATIVE REGULATION OF ERK1 AND ERK2 CASCADE 9 52 0.0001565 0.003866
187 REGULATION OF ERK1 AND ERK2 CASCADE 22 238 0.0001567 0.003866
188 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 108 1977 0.000155 0.003866
189 STEM CELL DIFFERENTIATION 19 190 0.000157 0.003866
190 GLIOGENESIS 18 175 0.0001628 0.003986
191 REGULATION OF DEVELOPMENTAL GROWTH 25 289 0.0001652 0.004024
192 CELLULAR RESPONSE TO NITROGEN COMPOUND 37 505 0.0001728 0.004187
193 POSITIVE REGULATION OF FIBROBLAST PROLIFERATION 9 53 0.000182 0.004322
194 MAMMARY GLAND EPITHELIUM DEVELOPMENT 9 53 0.000182 0.004322
195 POSITIVE REGULATION OF GLUCOSE TRANSPORT 8 42 0.0001812 0.004322
196 REGULATION OF HEART GROWTH 8 42 0.0001812 0.004322
197 NEURON PROJECTION DEVELOPMENT 39 545 0.0001893 0.004448
198 EYE DEVELOPMENT 27 326 0.0001886 0.004448
199 RESPONSE TO CAMP 13 104 0.0001927 0.004484
200 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 13 104 0.0001927 0.004484
201 EXOCYTOSIS 26 310 0.0002021 0.004677
202 CELL MATRIX ADHESION 14 119 0.0002122 0.004887
203 REGULATION OF VASOCONSTRICTION 10 66 0.0002152 0.004908
204 POSITIVE REGULATION OF LIPASE ACTIVITY 10 66 0.0002152 0.004908
205 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 85 1492 0.0002205 0.005005
206 MESENCHYMAL CELL DIFFERENTIATION 15 134 0.0002228 0.005032
207 POSITIVE REGULATION OF FATTY ACID METABOLIC PROCESS 7 33 0.0002276 0.005116
208 REGULATION OF FAT CELL DIFFERENTIATION 13 106 0.0002335 0.005224
209 TISSUE MORPHOGENESIS 38 533 0.0002452 0.005434
210 REGULATION OF CELL ADHESION 43 629 0.0002452 0.005434
211 MULTI MULTICELLULAR ORGANISM PROCESS 20 213 0.0002494 0.0055
212 RESPIRATORY SYSTEM DEVELOPMENT 19 197 0.0002509 0.005508
213 NEGATIVE REGULATION OF PHOSPHORYLATION 32 422 0.0002544 0.005558
214 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 17 166 0.000258 0.00561
215 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 14 122 0.0002758 0.005968
216 MUSCLE SYSTEM PROCESS 24 282 0.0002821 0.005995
217 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 9 56 0.0002806 0.005995
218 OUTFLOW TRACT MORPHOGENESIS 9 56 0.0002806 0.005995
219 RESPONSE TO OXIDATIVE STRESS 28 352 0.0002819 0.005995
220 REGULATION OF FIBROBLAST PROLIFERATION 11 81 0.0002848 0.006024
221 REGULATION OF GTPASE ACTIVITY 45 673 0.0002886 0.006076
222 REGULATION OF CELL PROJECTION ORGANIZATION 39 558 0.0003042 0.006355
223 PALLIUM DEVELOPMENT 16 153 0.0003059 0.006355
224 EMBRYONIC MORPHOGENESIS 38 539 0.0003057 0.006355
225 REGULATION OF VASCULATURE DEVELOPMENT 21 233 0.0003093 0.006397
226 POSITIVE REGULATION OF CELL COMMUNICATION 86 1532 0.0003263 0.006719
227 RESPONSE TO ORGANOPHOSPHORUS 15 139 0.0003328 0.006791
228 OSSIFICATION 22 251 0.0003322 0.006791
229 RESPONSE TO MINERALOCORTICOID 7 35 0.0003349 0.006805
230 CYCLIC NUCLEOTIDE MEDIATED SIGNALING 8 46 0.0003494 0.007069
231 REGULATION OF LIPASE ACTIVITY 11 83 0.0003535 0.00709
232 LIPID OXIDATION 10 70 0.000352 0.00709
233 BRANCH ELONGATION OF AN EPITHELIUM 5 17 0.0003639 0.007133
234 POSITIVE REGULATION OF GLYCOGEN METABOLIC PROCESS 5 17 0.0003639 0.007133
235 NEGATIVE REGULATION OF ANOIKIS 5 17 0.0003639 0.007133
236 CELL PROJECTION ORGANIZATION 56 902 0.0003647 0.007133
237 DEFINITIVE HEMOPOIESIS 5 17 0.0003639 0.007133
238 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 48 740 0.0003648 0.007133
239 NEGATIVE REGULATION OF GROWTH 21 236 0.0003675 0.007154
240 EPIDERMIS DEVELOPMENT 22 253 0.0003707 0.007188
241 BONE DEVELOPMENT 16 156 0.000381 0.007356
242 MUSCLE CELL DIFFERENTIATION 21 237 0.0003889 0.007477
243 REGULATION OF TRANSFERASE ACTIVITY 58 946 0.0003938 0.007541
244 RESPONSE TO CORTICOSTERONE 6 26 0.0003958 0.007548
245 REGULATION OF OSTEOBLAST DIFFERENTIATION 13 112 0.0004031 0.007656
246 MEMORY 12 98 0.0004076 0.00771
247 MULTICELLULAR ORGANISMAL HOMEOSTASIS 23 272 0.0004105 0.007711
248 ENDOCYTOSIS 36 509 0.000411 0.007711
249 REGULATION OF ANATOMICAL STRUCTURE SIZE 34 472 0.0004249 0.007941
250 REGULATION OF STEM CELL DIFFERENTIATION 13 113 0.0004397 0.008183
251 NEURON DEVELOPMENT 45 687 0.0004491 0.008293
252 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 18 190 0.0004486 0.008293
253 SENSORY ORGAN DEVELOPMENT 35 493 0.0004593 0.008446
254 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 32 437 0.0004686 0.008583
255 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 9 60 0.0004769 0.008685
256 RESPONSE TO REACTIVE OXYGEN SPECIES 18 191 0.0004778 0.008685
257 REGULATED EXOCYTOSIS 20 224 0.0004807 0.008703
258 CARDIAC CHAMBER DEVELOPMENT 15 144 0.0004865 0.008765
259 RESPONSE TO CAFFEINE 5 18 0.0004879 0.008765
260 POSITIVE REGULATION OF HEART GROWTH 6 27 0.0004923 0.008811
261 EMBRYO DEVELOPMENT 55 894 0.0005109 0.009108
262 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 13 115 0.0005213 0.009258
263 BEHAVIOR 36 516 0.000529 0.009359
264 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 9 61 0.0005405 0.009526
265 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 30 404 0.0005542 0.009731
266 COLLAGEN FIBRIL ORGANIZATION 7 38 0.0005682 0.009828
267 OXIDATION REDUCTION PROCESS 55 898 0.0005679 0.009828
268 REGULATION OF RENAL SYSTEM PROCESS 7 38 0.0005682 0.009828
269 POSITIVE REGULATION OF ORGAN GROWTH 7 38 0.0005682 0.009828
NumGOOverlapSizeP ValueAdj. P Value
1 GROWTH FACTOR BINDING 20 123 5.476e-08 5.087e-05
2 GLYCOSAMINOGLYCAN BINDING 26 205 1.133e-07 5.262e-05
3 SULFUR COMPOUND BINDING 27 234 4.509e-07 0.0001396
4 PROTEIN KINASE ACTIVITY 51 640 9.918e-07 0.0002304
5 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 50 629 1.362e-06 0.0002531
6 HEPARIN BINDING 20 157 3.026e-06 0.0004685
7 KINASE ACTIVITY 59 842 8.615e-06 0.001143
8 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 30 328 1.327e-05 0.001541
9 MACROMOLECULAR COMPLEX BINDING 85 1399 2.413e-05 0.002491
10 DOUBLE STRANDED DNA BINDING 53 764 3.255e-05 0.002955
11 CORE PROMOTER SEQUENCE SPECIFIC DNA BINDING 14 101 3.498e-05 0.002955
12 REGULATORY REGION NUCLEIC ACID BINDING 55 818 5.413e-05 0.003868
13 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 74 1199 5.07e-05 0.003868
14 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 12 81 6.468e-05 0.004292
15 ENZYME BINDING 98 1737 0.0001013 0.005722
16 PROTEIN DOMAIN SPECIFIC BINDING 44 624 0.0001047 0.005722
17 SEQUENCE SPECIFIC DNA BINDING 65 1037 9.446e-05 0.005722
18 FLAVIN ADENINE DINUCLEOTIDE BINDING 11 74 0.0001255 0.006357
19 CORE PROMOTER PROXIMAL REGION DNA BINDING 30 371 0.00013 0.006357
20 PROTEIN SERINE THREONINE KINASE ACTIVITY 34 445 0.0001432 0.00665
21 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 12 90 0.0001822 0.008062
22 KINASE BINDING 42 606 0.0002162 0.009131
NumGOOverlapSizeP ValueAdj. P Value
1 EXTRACELLULAR MATRIX 46 426 3.848e-10 2.247e-07
2 MEMBRANE REGION 87 1134 7.789e-10 2.274e-07
3 PROTEINACEOUS EXTRACELLULAR MATRIX 38 356 1.806e-08 3.516e-06
4 EXTRACELLULAR MATRIX COMPONENT 19 125 3.494e-07 5.101e-05
5 GOLGI APPARATUS 94 1445 4.793e-07 5.598e-05
6 SYNAPSE 56 754 2.636e-06 0.0002566
7 PLASMA MEMBRANE REGION 65 929 3.114e-06 0.0002598
8 BASEMENT MEMBRANE 14 93 1.347e-05 0.0009831
9 MEMBRANE MICRODOMAIN 27 288 2.293e-05 0.001488
10 EXTRACELLULAR SPACE 83 1376 3.904e-05 0.00228
11 COATED PIT 11 67 4.937e-05 0.002403
12 GOLGI APPARATUS PART 59 893 4.766e-05 0.002403
13 SYNAPSE PART 44 610 6.231e-05 0.002799
14 EXCITATORY SYNAPSE 20 197 8.642e-05 0.003365
15 INTRACELLULAR VESICLE 76 1259 8.214e-05 0.003365
16 NEURONAL POSTSYNAPTIC DENSITY 9 53 0.000182 0.006585
17 CLATHRIN VESICLE COAT 6 23 0.0001917 0.006585
18 VESICLE COAT 8 45 0.0002987 0.00969

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Focal_adhesion_hsa04510 29 199 8.403e-10 4.37e-08
2 AMPK_signaling_pathway_hsa04152 21 121 7.742e-09 2.013e-07
3 PI3K_Akt_signaling_pathway_hsa04151 38 352 1.33e-08 2.305e-07
4 MAPK_signaling_pathway_hsa04010 31 295 5.226e-07 6.794e-06
5 FoxO_signaling_pathway_hsa04068 18 132 3.534e-06 3.675e-05
6 cAMP_signaling_pathway_hsa04024 21 198 3.045e-05 0.0002639
7 Rap1_signaling_pathway_hsa04015 21 206 5.467e-05 0.0003909
8 Jak_STAT_signaling_pathway_hsa04630 18 162 6.014e-05 0.0003909
9 Apelin_signaling_pathway_hsa04371 16 137 8.404e-05 0.0004855
10 ECM_receptor_interaction_hsa04512 11 82 0.0003176 0.001652
11 Hedgehog_signaling_pathway_hsa04340 8 47 0.0004069 0.001924
12 Phospholipase_D_signaling_pathway_hsa04072 15 146 0.0005632 0.002441
13 Ras_signaling_pathway_hsa04014 20 232 0.0007494 0.002998
14 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 14 139 0.001033 0.003837
15 p53_signaling_pathway_hsa04115 9 68 0.001207 0.004185
16 Endocytosis_hsa04144 20 244 0.001391 0.004522
17 HIF_1_signaling_pathway_hsa04066 11 100 0.001713 0.005239
18 Cytokine_cytokine_receptor_interaction_hsa04060 21 270 0.002045 0.005909
19 TNF_signaling_pathway_hsa04668 11 108 0.003159 0.008231
20 Regulation_of_actin_cytoskeleton_hsa04810 17 208 0.003166 0.008231
21 Cellular_senescence_hsa04218 14 160 0.003863 0.009566
22 Calcium_signaling_pathway_hsa04020 15 182 0.00498 0.01177
23 ErbB_signaling_pathway_hsa04012 9 85 0.005639 0.01275
24 Hippo_signaling_pathway_hsa04390 13 154 0.007075 0.01533
25 Adherens_junction_hsa04520 7 72 0.02142 0.04455
26 Mitophagy_animal_hsa04137 6 65 0.03991 0.07983
27 Peroxisome_hsa04146 7 83 0.04215 0.08117
28 Neuroactive_ligand_receptor_interaction_hsa04080 17 278 0.04392 0.08156
29 cGMP_PKG_signaling_pathway_hsa04022 11 163 0.05311 0.09497
30 Gap_junction_hsa04540 7 88 0.05479 0.09497
31 Wnt_signaling_pathway_hsa04310 10 146 0.05832 0.09783
32 mTOR_signaling_pathway_hsa04150 10 151 0.06983 0.1135
33 Phosphatidylinositol_signaling_system_hsa04070 7 99 0.09017 0.1421
34 ABC_transporters_hsa02010 4 45 0.09608 0.1469
35 TGF_beta_signaling_pathway_hsa04350 6 84 0.1077 0.1601
36 Apoptosis_hsa04210 8 138 0.1683 0.2431
37 Sphingolipid_signaling_pathway_hsa04071 7 118 0.1748 0.2457
38 VEGF_signaling_pathway_hsa04370 4 59 0.1953 0.2673
39 Ferroptosis_hsa04216 3 40 0.2019 0.2689
40 Oocyte_meiosis_hsa04114 7 124 0.2069 0.2689
41 NF_kappa_B_signaling_pathway_hsa04064 5 95 0.3087 0.3851
42 Hippo_signaling_pathway_multiple_species_hsa04392 2 29 0.3111 0.3851
43 Cell_adhesion_molecules_.CAMs._hsa04514 7 145 0.3324 0.4016
44 Tight_junction_hsa04530 8 170 0.3398 0.4016
45 Autophagy_animal_hsa04140 6 128 0.378 0.4368
46 Lysosome_hsa04142 4 123 0.7078 0.7896
47 Cell_cycle_hsa04110 4 124 0.7137 0.7896
48 Necroptosis_hsa04217 3 164 0.956 0.9942
49 Phagosome_hsa04145 2 152 0.9829 1

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

MIR143HG

hsa-miR-107;hsa-miR-193a-3p;hsa-miR-320b;hsa-miR-330-5p;hsa-miR-338-3p;hsa-miR-339-5p;hsa-miR-342-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p 10 SVEP1 Sponge network -4.451 0 -3.504 0 0.756
2

MIR143HG

hsa-miR-193a-3p;hsa-miR-320b;hsa-miR-330-5p;hsa-miR-338-3p;hsa-miR-339-5p;hsa-miR-342-3p;hsa-miR-34a-5p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p 10 PDGFRA Sponge network -4.451 0 -1.842 0 0.597

Quest ID: 51678f36006446c55d4dc88dae5f05ea