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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-106b-5p DDX17 1.22 0 -0.43 0 miRNAWalker2 validate -0.12 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 RNA PROCESSING 162 835 4.331e-107 2.015e-103
2 NCRNA METABOLIC PROCESS 119 533 3.741e-84 8.703e-81
3 NCRNA PROCESSING 103 386 7.786e-81 1.208e-77
4 RIBONUCLEOPROTEIN COMPLEX BIOGENESIS 108 440 1.088e-80 1.265e-77
5 RIBOSOME BIOGENESIS 92 308 6.734e-77 6.267e-74
6 RRNA METABOLIC PROCESS 78 255 7.501e-66 5.817e-63
7 MRNA METABOLIC PROCESS 94 611 1.706e-50 1.134e-47
8 AMIDE BIOSYNTHETIC PROCESS 77 507 9.838e-41 5.722e-38
9 ORGANONITROGEN COMPOUND BIOSYNTHETIC PROCESS 101 1024 1.312e-36 6.785e-34
10 PEPTIDE METABOLIC PROCESS 74 571 2.331e-34 1.085e-31
11 CELLULAR AMIDE METABOLIC PROCESS 79 727 2.743e-31 1.16e-28
12 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 61 448 1.564e-29 6.066e-27
13 RNA CATABOLIC PROCESS 44 227 5.663e-28 2.027e-25
14 TRANSLATIONAL INITIATION 36 146 6.169e-27 2.05e-24
15 RNA SPLICING VIA TRANSESTERIFICATION REACTIONS 46 267 7.008e-27 2.174e-24
16 PROTEIN FOLDING 42 224 3.873e-26 1.126e-23
17 TRNA METABOLIC PROCESS 38 176 4.312e-26 1.18e-23
18 MRNA PROCESSING 56 432 4.751e-26 1.228e-23
19 RNA MODIFICATION 32 120 3.152e-25 7.534e-23
20 ORGANONITROGEN COMPOUND METABOLIC PROCESS 116 1796 3.383e-25 7.534e-23
21 RNA SPLICING 51 367 3.4e-25 7.534e-23
22 INTERSPECIES INTERACTION BETWEEN ORGANISMS 66 662 5.321e-24 1.076e-21
23 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 66 662 5.321e-24 1.076e-21
24 NUCLEAR TRANSCRIBED MRNA CATABOLIC PROCESS NONSENSE MEDIATED DECAY 28 118 1.027e-20 1.992e-18
25 RIBONUCLEOPROTEIN COMPLEX SUBUNIT ORGANIZATION 34 199 5.177e-20 9.635e-18
26 MULTI ORGANISM METABOLIC PROCESS 29 138 7.83e-20 1.401e-17
27 ORGANIC CYCLIC COMPOUND CATABOLIC PROCESS 47 427 5.197e-19 8.956e-17
28 TRNA PROCESSING 26 114 7.391e-19 1.228e-16
29 RIBOSOMAL SMALL SUBUNIT BIOGENESIS 20 59 1.517e-18 2.433e-16
30 TRNA MODIFICATION 20 60 2.227e-18 3.454e-16
31 DNA METABOLIC PROCESS 62 758 3.384e-18 5.08e-16
32 RNA LOCALIZATION 31 185 4.257e-18 6.19e-16
33 REGULATION OF TELOMERASE RNA LOCALIZATION TO CAJAL BODY 12 15 8.568e-18 1.173e-15
34 POSITIVE REGULATION OF TELOMERASE RNA LOCALIZATION TO CAJAL BODY 12 15 8.568e-18 1.173e-15
35 CELLULAR RESPONSE TO STRESS 93 1565 1.378e-17 1.832e-15
36 MATURATION OF SSU RRNA 17 42 1.699e-17 2.137e-15
37 REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 41 354 1.68e-17 2.137e-15
38 VIRAL LIFE CYCLE 37 290 2.765e-17 3.385e-15
39 PROTEIN LOCALIZATION TO ORGANELLE 51 556 3.84e-17 4.581e-15
40 MATURATION OF SSU RRNA FROM TRICISTRONIC RRNA TRANSCRIPT SSU RRNA 5 8S RRNA LSU RRNA 15 33 1.61e-16 1.873e-14
41 MACROMOLECULE CATABOLIC PROCESS 66 926 2.694e-16 3.057e-14
42 CELLULAR MACROMOLECULAR COMPLEX ASSEMBLY 57 727 5.821e-16 6.449e-14
43 PROTEIN LOCALIZATION TO ENDOPLASMIC RETICULUM 24 123 7.503e-16 8.119e-14
44 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ORGANELLE 39 361 1.129e-15 1.194e-13
45 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ENDOPLASMIC RETICULUM 22 104 2.044e-15 2.114e-13
46 RIBOSOME ASSEMBLY 17 54 2.438e-15 2.466e-13
47 RIBOSOMAL LARGE SUBUNIT BIOGENESIS 16 49 8.453e-15 8.368e-13
48 PROTEIN TARGETING 40 406 1.093e-14 1.06e-12
49 REGULATION OF RNA STABILITY 24 139 1.348e-14 1.28e-12
50 RNA 3 END PROCESSING 20 98 8.095e-14 7.533e-12
51 DNA TEMPLATED TRANSCRIPTION TERMINATION 20 101 1.483e-13 1.353e-11
52 RIBONUCLEOPROTEIN COMPLEX LOCALIZATION 21 118 3.327e-13 2.977e-11
53 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 51 720 1.151e-12 1.01e-10
54 MACROMOLECULAR COMPLEX ASSEMBLY 76 1398 2.031e-12 1.75e-10
55 RRNA MODIFICATION 11 27 8.297e-12 7.019e-10
56 NUCLEAR TRANSPORT 33 355 1.243e-11 1.033e-09
57 PROTEIN TARGETING TO MEMBRANE 22 157 1.33e-11 1.086e-09
58 PROTEIN STABILIZATION 20 131 2.315e-11 1.857e-09
59 NUCLEAR EXPORT 21 147 2.683e-11 2.116e-09
60 MITOCHONDRION ORGANIZATION 43 594 3.83e-11 2.97e-09
61 MITOCHONDRIAL TRANSLATION 18 107 4.421e-11 3.373e-09
62 PYRIMIDINE NUCLEOTIDE BIOSYNTHETIC PROCESS 11 31 4.957e-11 3.72e-09
63 CYTOPLASMIC TRANSLATION 12 41 8.622e-11 6.368e-09
64 SINGLE ORGANISM BIOSYNTHETIC PROCESS 70 1340 1.04e-10 7.561e-09
65 TRNA AMINOACYLATION 13 52 1.261e-10 8.893e-09
66 AMINO ACID ACTIVATION 13 52 1.261e-10 8.893e-09
67 ESTABLISHMENT OF LOCALIZATION IN CELL 81 1676 1.293e-10 8.98e-09
68 CHROMOSOME ORGANIZATION 58 1009 1.424e-10 9.743e-09
69 REGULATION OF DNA REPLICATION 21 161 1.542e-10 1.04e-08
70 RESPONSE TO TOPOLOGICALLY INCORRECT PROTEIN 21 163 1.949e-10 1.296e-08
71 REGULATION OF PROTEIN LOCALIZATION TO CHROMOSOME TELOMERIC REGION 8 14 2.03e-10 1.33e-08
72 RNA SECONDARY STRUCTURE UNWINDING 12 44 2.162e-10 1.397e-08
73 PYRIMIDINE NUCLEOSIDE TRIPHOSPHATE BIOSYNTHETIC PROCESS 9 20 2.323e-10 1.481e-08
74 NUCLEIC ACID PHOSPHODIESTER BOND HYDROLYSIS 26 254 2.44e-10 1.514e-08
75 NUCLEOBASE CONTAINING COMPOUND TRANSPORT 23 199 2.432e-10 1.514e-08
76 POSITIVE REGULATION OF DNA METABOLIC PROCESS 22 185 3.457e-10 2.117e-08
77 DNA BIOSYNTHETIC PROCESS 18 121 3.613e-10 2.155e-08
78 REGULATION OF PROTEIN STABILITY 24 221 3.605e-10 2.155e-08
79 CELLULAR CATABOLIC PROCESS 68 1322 3.873e-10 2.281e-08
80 NUCLEOSIDE PHOSPHATE BIOSYNTHETIC PROCESS 22 188 4.721e-10 2.746e-08
81 DNA REPAIR 36 480 6.2e-10 3.561e-08
82 NUCLEOTIDE EXCISION REPAIR 17 113 9.351e-10 5.306e-08
83 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO CHROMOSOME 7 11 1.022e-09 5.73e-08
84 REGULATION OF TELOMERE MAINTENANCE VIA TELOMERE LENGTHENING 12 50 1.097e-09 6.079e-08
85 PSEUDOURIDINE SYNTHESIS 8 17 1.546e-09 8.463e-08
86 REGULATION OF DNA METABOLIC PROCESS 29 340 1.684e-09 9.007e-08
87 PYRIMIDINE NUCLEOSIDE TRIPHOSPHATE METABOLIC PROCESS 9 24 1.666e-09 9.007e-08
88 REGULATION OF MRNA METABOLIC PROCESS 17 118 1.858e-09 9.823e-08
89 PYRIMIDINE CONTAINING COMPOUND BIOSYNTHETIC PROCESS 11 42 1.993e-09 1.042e-07
90 TRANSLATIONAL ELONGATION 16 111 5.538e-09 2.863e-07
91 CELLULAR MACROMOLECULE LOCALIZATION 62 1234 6.275e-09 3.209e-07
92 INTRACELLULAR PROTEIN TRANSPORT 46 781 6.378e-09 3.226e-07
93 PROTEIN REFOLDING 8 20 7.536e-09 3.771e-07
94 MATURATION OF 5 8S RRNA 9 28 8.105e-09 4.012e-07
95 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 18 147 8.839e-09 4.329e-07
96 PYRIMIDINE NUCLEOTIDE METABOLIC PROCESS 11 48 9.283e-09 4.499e-07
97 NCRNA 3 END PROCESSING 8 21 1.193e-08 5.722e-07
98 METHYLATION 25 284 1.215e-08 5.768e-07
99 MACROMOLECULE METHYLATION 21 205 1.308e-08 6.149e-07
100 REGULATION OF CELL DEATH 69 1472 1.325e-08 6.167e-07
101 NUCLEOSIDE TRIPHOSPHATE METABOLIC PROCESS 22 228 1.77e-08 8.155e-07
102 CATABOLIC PROCESS 78 1773 2.062e-08 9.406e-07
103 NUCLEOSIDE TRIPHOSPHATE BIOSYNTHETIC PROCESS 12 64 2.215e-08 1.001e-06
104 SINGLE ORGANISM CELLULAR LOCALIZATION 49 898 2.296e-08 1.027e-06
105 NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 17 139 2.333e-08 1.034e-06
106 REGULATION OF RESPONSE TO STRESS 68 1468 2.733e-08 1.2e-06
107 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR 9 32 3.032e-08 1.306e-06
108 DNA RECOMBINATION 21 215 3.026e-08 1.306e-06
109 REGULATION OF CELL CYCLE PHASE TRANSITION 26 321 3.422e-08 1.461e-06
110 NUCLEOBASE CONTAINING SMALL MOLECULE METABOLIC PROCESS 35 535 3.585e-08 1.517e-06
111 REGULATION OF CELLULAR RESPONSE TO STRESS 41 691 3.642e-08 1.527e-06
112 REGULATION OF TELOMERE MAINTENANCE 12 67 3.799e-08 1.578e-06
113 REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 17 145 4.403e-08 1.813e-06
114 ESTABLISHMENT OF PROTEIN LOCALIZATION TO MEMBRANE 23 264 5.671e-08 2.315e-06
115 SNORNA METABOLIC PROCESS 6 11 6.161e-08 2.493e-06
116 RNA METHYLATION 11 57 6.286e-08 2.521e-06
117 TELOMERE MAINTENANCE VIA TELOMERE LENGTHENING 8 26 8.273e-08 3.29e-06
118 RIBOSOMAL SMALL SUBUNIT ASSEMBLY 7 18 8.565e-08 3.377e-06
119 TOXIN TRANSPORT 9 36 9.375e-08 3.666e-06
120 TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR 12 73 1.028e-07 3.984e-06
121 DNA CONFORMATION CHANGE 23 273 1.047e-07 4.025e-06
122 RNA PHOSPHODIESTER BOND HYDROLYSIS 15 120 1.168e-07 4.455e-06
123 RNA CAPPING 9 37 1.214e-07 4.518e-06
124 X7 METHYLGUANOSINE RNA CAPPING 9 37 1.214e-07 4.518e-06
125 UTP METABOLIC PROCESS 6 12 1.208e-07 4.518e-06
126 REGULATION OF CELL CYCLE 49 949 1.257e-07 4.642e-06
127 TERMINATION OF RNA POLYMERASE II TRANSCRIPTION 11 62 1.561e-07 5.718e-06
128 HISTONE MRNA METABOLIC PROCESS 8 28 1.58e-07 5.745e-06
129 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 23 280 1.654e-07 5.968e-06
130 REGULATION OF DNA BIOSYNTHETIC PROCESS 13 94 2.478e-07 8.869e-06
131 DNA GEOMETRIC CHANGE 12 81 3.345e-07 1.188e-05
132 REGULATION OF MITOTIC CELL CYCLE 30 468 5.351e-07 1.886e-05
133 POSITIVE REGULATION OF CELL CYCLE ARREST 12 85 5.724e-07 2.003e-05
134 REGULATION OF NUCLEASE ACTIVITY 7 23 5.969e-07 2.057e-05
135 RIBOSOMAL LARGE SUBUNIT ASSEMBLY 7 23 5.969e-07 2.057e-05
136 POSITIVE REGULATION OF TELOMERE MAINTENANCE VIA TELOMERE LENGTHENING 8 33 6.379e-07 2.182e-05
137 POSITIVE REGULATION OF DNA REPLICATION 12 86 6.515e-07 2.213e-05
138 GLYCOSYL COMPOUND BIOSYNTHETIC PROCESS 14 120 7.269e-07 2.451e-05
139 MRNA 3 END PROCESSING 11 72 7.54e-07 2.524e-05
140 TELOMERE ORGANIZATION 13 104 8.162e-07 2.713e-05
141 REGULATION OF TRANSLATIONAL ELONGATION 7 24 8.259e-07 2.726e-05
142 POSITIVE REGULATION OF DNA BIOSYNTHETIC PROCESS 10 59 8.957e-07 2.914e-05
143 REGULATION OF OXIDATIVE STRESS INDUCED CELL DEATH 9 46 8.938e-07 2.914e-05
144 CELLULAR AMINO ACID METABOLIC PROCESS 24 332 9.225e-07 2.981e-05
145 GUANOSINE CONTAINING COMPOUND BIOSYNTHETIC PROCESS 6 16 9.678e-07 3.084e-05
146 REGULATION OF INCLUSION BODY ASSEMBLY 6 16 9.678e-07 3.084e-05
147 TRANSCRIPTION FROM RNA POLYMERASE I PROMOTER 8 35 1.038e-06 3.287e-05
148 POSITIVE REGULATION OF TELOMERE MAINTENANCE 9 47 1.083e-06 3.405e-05
149 PYRIMIDINE RIBONUCLEOTIDE METABOLIC PROCESS 7 25 1.124e-06 3.488e-05
150 TRNA METHYLATION 7 25 1.124e-06 3.488e-05
151 REGULATION OF VIRAL GENOME REPLICATION 11 75 1.148e-06 3.538e-05
152 TRANSLATIONAL TERMINATION 12 92 1.364e-06 4.176e-05
153 PYRIMIDINE RIBONUCLEOSIDE TRIPHOSPHATE METABOLIC PROCESS 6 17 1.467e-06 4.46e-05
154 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 14 129 1.754e-06 5.299e-05
155 PYRIMIDINE CONTAINING COMPOUND METABOLIC PROCESS 11 79 1.95e-06 5.853e-05
156 NEGATIVE REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 14 131 2.11e-06 6.294e-05
157 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 12 96 2.161e-06 6.364e-05
158 NUCLEOBASE BIOSYNTHETIC PROCESS 6 18 2.157e-06 6.364e-05
159 ERBB2 SIGNALING PATHWAY 8 39 2.503e-06 7.28e-05
160 PROTEIN LOCALIZATION TO MEMBRANE 25 376 2.503e-06 7.28e-05
161 RIBONUCLEOSIDE TRIPHOSPHATE BIOSYNTHETIC PROCESS 9 52 2.64e-06 7.63e-05
162 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 12 98 2.695e-06 7.742e-05
163 SNRNA METABOLIC PROCESS 11 82 2.839e-06 8.104e-05
164 CELL REDOX HOMEOSTASIS 10 67 2.998e-06 8.506e-05
165 ERROR FREE TRANSLESION SYNTHESIS 6 19 3.091e-06 8.613e-05
166 MATURATION OF 5 8S RRNA FROM TRICISTRONIC RRNA TRANSCRIPT SSU RRNA 5 8S RRNA LSU RRNA 6 19 3.091e-06 8.613e-05
167 X DE NOVO PROTEIN FOLDING 6 19 3.091e-06 8.613e-05
168 NUCLEOSIDE MONOPHOSPHATE METABOLIC PROCESS 19 239 3.195e-06 8.848e-05
169 REGULATION OF OXIDATIVE STRESS INDUCED INTRINSIC APOPTOTIC SIGNALING PATHWAY 7 29 3.37e-06 9.279e-05
170 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 24 360 3.798e-06 0.0001039
171 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 17 199 4.013e-06 0.0001092
172 PURINE CONTAINING COMPOUND BIOSYNTHETIC PROCESS 14 139 4.27e-06 0.0001148
173 MITOTIC CELL CYCLE CHECKPOINT 14 139 4.27e-06 0.0001148
174 CELLULAR PROTEIN COMPLEX DISASSEMBLY 13 122 5.029e-06 0.0001345
175 POSITIVE REGULATION OF CELL CYCLE PROCESS 19 247 5.166e-06 0.0001373
176 NUCLEAR TRANSCRIBED MRNA CATABOLIC PROCESS DEADENYLATION DEPENDENT DECAY 9 57 5.829e-06 0.0001541
177 REGULATION OF SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 17 205 5.983e-06 0.0001573
178 PROTEIN LOCALIZATION 71 1805 6.033e-06 0.0001577
179 PURINE NUCLEOSIDE BIOSYNTHETIC PROCESS 11 89 6.405e-06 0.0001656
180 PURINE RIBONUCLEOSIDE BIOSYNTHETIC PROCESS 11 89 6.405e-06 0.0001656
181 G1 DNA DAMAGE CHECKPOINT 10 73 6.638e-06 0.0001707
182 PYRIMIDINE NUCLEOSIDE BIOSYNTHETIC PROCESS 7 32 6.845e-06 0.000174
183 REGULATION OF CELL CYCLE PROCESS 31 558 6.814e-06 0.000174
184 MATURATION OF LSU RRNA 5 13 7.108e-06 0.0001788
185 RRNA 3 END PROCESSING 5 13 7.108e-06 0.0001788
186 NEGATIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 11 90 7.147e-06 0.0001788
187 DNA SYNTHESIS INVOLVED IN DNA REPAIR 10 74 7.519e-06 0.0001861
188 REGULATION OF CELL CYCLE ARREST 12 108 7.515e-06 0.0001861
189 SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 13 127 7.846e-06 0.0001932
190 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 62 1517 7.895e-06 0.0001934
191 PYRIMIDINE RIBONUCLEOSIDE METABOLIC PROCESS 7 33 8.516e-06 0.0002064
192 BINDING OF SPERM TO ZONA PELLUCIDA 7 33 8.516e-06 0.0002064
193 NUCLEAR IMPORT 13 129 9.314e-06 0.0002246
194 REGULATION OF TYPE I INTERFERON PRODUCTION 12 111 9.984e-06 0.0002395
195 NUCLEOTIDE PHOSPHORYLATION 9 61 1.035e-05 0.0002471
196 POSITIVE REGULATION OF CELL CYCLE 22 332 1.056e-05 0.0002507
197 RNA SURVEILLANCE 5 14 1.085e-05 0.0002544
198 X DE NOVO POSTTRANSLATIONAL PROTEIN FOLDING 5 14 1.085e-05 0.0002544
199 CHAPERONE MEDIATED PROTEIN FOLDING 8 47 1.088e-05 0.0002544
200 REGULATION OF MRNA SPLICING VIA SPLICEOSOME 9 62 1.187e-05 0.0002761
201 CELL CYCLE CHECKPOINT 16 194 1.2e-05 0.0002777
202 NEGATIVE REGULATION OF RESPONSE TO OXIDATIVE STRESS 7 35 1.288e-05 0.0002952
203 NEGATIVE REGULATION OF CELLULAR RESPONSE TO OXIDATIVE STRESS 7 35 1.288e-05 0.0002952
204 POSITIVE REGULATION OF CELL DEATH 32 605 1.309e-05 0.0002987
205 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 48 1087 1.317e-05 0.000299
206 PEPTIDYL AMINO ACID MODIFICATION 40 841 1.362e-05 0.0003076
207 REGULATION OF APOPTOTIC SIGNALING PATHWAY 23 363 1.378e-05 0.0003098
208 NEGATIVE REGULATION OF CELL DEATH 41 872 1.387e-05 0.0003104
209 CELL CYCLE 55 1316 1.451e-05 0.0003231
210 REGULATION OF RNA SPLICING 11 97 1.478e-05 0.0003276
211 REGULATION OF MULTI ORGANISM PROCESS 27 470 1.487e-05 0.000328
212 CELLULAR RESPONSE TO HEAT 7 36 1.567e-05 0.0003424
213 DNA DAMAGE RESPONSE DETECTION OF DNA DAMAGE 7 36 1.567e-05 0.0003424
214 POSITIVE REGULATION OF NUCLEASE ACTIVITY 5 15 1.596e-05 0.0003471
215 PROTEIN LOCALIZATION TO NUCLEUS 14 156 1.623e-05 0.0003512
216 PROTEIN METHYLATION 12 117 1.713e-05 0.000366
217 GLYCOSYL COMPOUND METABOLIC PROCESS 23 368 1.715e-05 0.000366
218 PROTEIN ALKYLATION 12 117 1.713e-05 0.000366
219 REGULATION OF RESPONSE TO OXIDATIVE STRESS 9 65 1.759e-05 0.0003738
220 NEGATIVE REGULATION OF GENE EXPRESSION 60 1493 1.86e-05 0.0003934
221 REGULATION OF TRANSLATIONAL INITIATION 10 82 1.899e-05 0.0003999
222 MITOTIC DNA INTEGRITY CHECKPOINT 11 100 1.978e-05 0.0004147
223 MACROMOLECULAR COMPLEX DISASSEMBLY 15 182 2.255e-05 0.0004706
224 SPLICEOSOMAL SNRNP ASSEMBLY 7 38 2.277e-05 0.000473
225 NUCLEOTIDE EXCISION REPAIR DNA INCISION 7 39 2.72e-05 0.0005626
226 RNA DEPENDENT DNA BIOSYNTHETIC PROCESS 6 27 2.883e-05 0.0005935
227 TELOMERE MAINTENANCE VIA TELOMERASE 5 17 3.166e-05 0.0006489
228 ESTABLISHMENT OF PROTEIN LOCALIZATION 57 1423 3.366e-05 0.000687
229 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 13 146 3.521e-05 0.0007123
230 REGULATION OF BINDING 19 283 3.508e-05 0.0007123
231 TRANSLESION SYNTHESIS 7 41 3.821e-05 0.0007697
232 RESPONSE TO HEAT 10 89 3.911e-05 0.0007843
233 REGULATION OF MITOPHAGY 7 42 4.495e-05 0.0008976
234 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 31 616 4.603e-05 0.0009153
235 POSITIVE REGULATION OF CHROMOSOME ORGANIZATION 13 150 4.673e-05 0.0009252
236 MITOTIC CELL CYCLE 36 766 4.748e-05 0.0009362
237 PURINE CONTAINING COMPOUND METABOLIC PROCESS 23 394 4.974e-05 0.0009725
238 CELL CYCLE PROCESS 46 1081 4.972e-05 0.0009725
239 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 16 218 5.028e-05 0.000979
240 POSITIVE REGULATION OF VIRAL PROCESS 10 92 5.214e-05 0.001011
241 REGULATION OF TELOMERASE ACTIVITY 7 43 5.263e-05 0.001016
242 CLEAVAGE INVOLVED IN RRNA PROCESSING 5 19 5.726e-05 0.001096
243 ERROR PRONE TRANSLESION SYNTHESIS 5 19 5.726e-05 0.001096
244 NEGATIVE REGULATION OF ERBB SIGNALING PATHWAY 7 44 6.135e-05 0.00117
245 REGULATION OF CELLULAR RESPONSE TO HEAT 9 76 6.266e-05 0.00119
246 NUCLEAR TRANSCRIBED MRNA CATABOLIC PROCESS EXONUCLEOLYTIC 6 31 6.63e-05 0.001254
247 SPERM EGG RECOGNITION 7 45 7.123e-05 0.001342
248 INTRACELLULAR ESTROGEN RECEPTOR SIGNALING PATHWAY 5 20 7.49e-05 0.001405
249 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 68 1848 7.997e-05 0.001494
250 DNA TEMPLATED TRANSCRIPTION ELONGATION 10 97 8.209e-05 0.001528
251 ERBB SIGNALING PATHWAY 9 79 8.517e-05 0.001579
252 RNA PHOSPHODIESTER BOND HYDROLYSIS ENDONUCLEOLYTIC 8 62 8.645e-05 0.001596
253 REGULATION OF TRANSFERASE ACTIVITY 41 946 8.716e-05 0.001603
254 REGULATION OF CHROMOSOME ORGANIZATION 18 278 8.926e-05 0.001635
255 PROTEIN DNA COMPLEX SUBUNIT ORGANIZATION 16 229 9.02e-05 0.001639
256 REGULATION OF GENE EXPRESSION EPIGENETIC 16 229 9.02e-05 0.001639
257 RESPONSE TO BIOTIC STIMULUS 39 886 9.409e-05 0.001704
258 NEGATIVE REGULATION OF OXIDATIVE STRESS INDUCED INTRINSIC APOPTOTIC SIGNALING PATHWAY 5 21 9.645e-05 0.001739
259 DNA DEPENDENT DNA REPLICATION 10 99 9.76e-05 0.001753
260 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 16 233 0.0001104 0.001976
261 DEFENSE RESPONSE TO VIRUS 13 164 0.0001167 0.002081
262 NEGATIVE REGULATION OF TELOMERE MAINTENANCE VIA TELOMERASE 4 12 0.0001201 0.002124
263 PURINE NUCLEOBASE BIOSYNTHETIC PROCESS 4 12 0.0001201 0.002124
264 NUCLEOTIDE EXCISION REPAIR DNA DUPLEX UNWINDING 5 22 0.0001225 0.00215
265 SNRNA PROCESSING 5 22 0.0001225 0.00215
266 NUCLEOSIDE MONOPHOSPHATE BIOSYNTHETIC PROCESS 9 83 0.0001254 0.002194
267 PEPTIDYL LYSINE MODIFICATION 19 312 0.0001287 0.002242
268 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 8 66 0.0001355 0.002327
269 NEGATIVE REGULATION OF MRNA METABOLIC PROCESS 6 35 0.0001352 0.002327
270 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 8 66 0.0001355 0.002327
271 RESPONSE TO CYTOKINE 33 714 0.0001343 0.002327
272 REGULATION OF CIRCADIAN RHYTHM 10 103 0.0001362 0.00233
273 NUCLEOSIDE DIPHOSPHATE METABOLIC PROCESS 9 84 0.0001376 0.002337
274 FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 9 84 0.0001376 0.002337
275 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 24 450 0.0001392 0.002348
276 NITROGEN COMPOUND TRANSPORT 26 507 0.0001393 0.002348
277 NEGATIVE REGULATION OF CELL CYCLE PROCESS 15 214 0.0001434 0.002409
278 DNA INTEGRITY CHECKPOINT 12 146 0.0001508 0.002523
279 NUCLEOBASE CONTAINING SMALL MOLECULE INTERCONVERSION 5 23 0.0001535 0.002551
280 GTP METABOLIC PROCESS 5 23 0.0001535 0.002551
281 PYRIMIDINE NUCLEOSIDE METABOLIC PROCESS 7 51 0.0001613 0.002671
282 MITOCHONDRIAL RNA PROCESSING 4 13 0.0001703 0.00281
283 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 28 573 0.0001747 0.002862
284 CHROMATIN ORGANIZATION 31 663 0.0001746 0.002862
285 REGULATION OF MITOCHONDRION ORGANIZATION 15 218 0.0001758 0.002869
286 ORGANOPHOSPHATE METABOLIC PROCESS 38 885 0.0001912 0.00309
287 NUCLEOTIDE EXCISION REPAIR DNA GAP FILLING 5 24 0.0001903 0.00309
288 CELLULAR RESPONSE TO CYTOKINE STIMULUS 29 606 0.0001912 0.00309
289 NEGATIVE REGULATION OF CELL CYCLE 23 433 0.0002024 0.003259
290 SPLICEOSOMAL COMPLEX ASSEMBLY 7 53 0.0002064 0.003312
291 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 65 1805 0.0002156 0.003441
292 RESPONSE TO VIRUS 16 247 0.0002159 0.003441
293 REGULATION OF CELLULAR PROTEIN LOCALIZATION 27 552 0.0002239 0.003555
294 INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY 8 71 0.000227 0.003593
295 NEGATIVE REGULATION OF RNA SPLICING 5 25 0.0002333 0.00363
296 POSTREPLICATION REPAIR 7 54 0.0002325 0.00363
297 CYTOPLASMIC TRANSLATIONAL INITIATION 4 14 0.0002341 0.00363
298 NEGATIVE REGULATION OF BINDING 11 131 0.0002339 0.00363
299 HISTONE MRNA CATABOLIC PROCESS 4 14 0.0002341 0.00363
300 PEPTIDYL ARGININE METHYLATION 4 14 0.0002341 0.00363
301 ORGANELLE ASSEMBLY 25 495 0.0002352 0.003635
302 NUCLEOBASE METABOLIC PROCESS 6 39 0.0002513 0.003872
303 NEGATIVE REGULATION OF DNA REPLICATION 7 55 0.0002612 0.00401
304 PROTEIN IMPORT 12 155 0.0002638 0.004037
305 CELLULAR RESPONSE TO INTERLEUKIN 4 5 26 0.0002835 0.004324
306 TRANSCRIPTION FROM RNA POLYMERASE III PROMOTER 6 40 0.00029 0.004409
307 DEFENSE RESPONSE TO OTHER ORGANISM 25 505 0.0003174 0.004811
308 POSITIVE REGULATION OF PROTEOLYSIS 20 363 0.0003251 0.004912
309 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 69 1977 0.0003332 0.005002
310 MITOTIC RECOMBINATION 6 41 0.0003331 0.005002
311 CELLULAR RESPONSE TO OXIDATIVE STRESS 13 184 0.0003631 0.005433
312 REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 12 162 0.0003954 0.005896
313 REGULATION OF INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY 7 59 0.0004056 0.00603
314 REGULATION OF TRANSLATIONAL FIDELITY 4 16 0.0004102 0.006079
315 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 25 514 0.0004122 0.006089
316 CELLULAR RESPONSE TO BIOTIC STIMULUS 12 163 0.0004181 0.006156
317 CELLULAR COMPONENT DISASSEMBLY 25 515 0.0004242 0.006226
318 REGULATION OF CATABOLIC PROCESS 32 731 0.0004397 0.006433
319 CELL CELL RECOGNITION 7 60 0.0004502 0.006566
320 COVALENT CHROMATIN MODIFICATION 19 345 0.0004575 0.006653
321 SOMATIC DIVERSIFICATION OF IMMUNOGLOBULINS 5 29 0.0004834 0.006942
322 NUCLEOTIDE EXCISION REPAIR PREINCISION COMPLEX ASSEMBLY 5 29 0.0004834 0.006942
323 MAINTENANCE OF PROTEIN LOCALIZATION IN ORGANELLE 5 29 0.0004834 0.006942
324 MITOCHONDRIAL RNA METABOLIC PROCESS 5 29 0.0004834 0.006942
325 NEGATIVE REGULATION OF TELOMERE MAINTENANCE VIA TELOMERE LENGTHENING 4 17 0.0005267 0.007495
326 NEGATIVE REGULATION OF CIRCADIAN RHYTHM 4 17 0.0005267 0.007495
327 RRNA CATABOLIC PROCESS 4 17 0.0005267 0.007495
328 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHETIC PROCESS 7 62 0.000551 0.00777
329 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 12 168 0.0005488 0.00777
330 PURINE NUCLEOSIDE MONOPHOSPHATE BIOSYNTHETIC PROCESS 7 62 0.000551 0.00777
331 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 28 616 0.0005567 0.007825
332 POSITIVE REGULATION OF VIRAL GENOME REPLICATION 5 30 0.0005692 0.007977
333 DNA PACKAGING 13 194 0.0006008 0.008395
334 GUANOSINE CONTAINING COMPOUND METABOLIC PROCESS 6 46 0.0006297 0.008772
335 REGULATION OF ORGANELLE ORGANIZATION 45 1178 0.0006533 0.009074
336 REGULATION OF ERBB SIGNALING PATHWAY 8 83 0.0006617 0.009139
337 NEGATIVE REGULATION OF RESPONSE TO REACTIVE OXYGEN SPECIES 4 18 0.0006649 0.009139
338 RESPONSE TO INTERLEUKIN 4 5 31 0.0006659 0.009139
339 RESPONSE TO TEMPERATURE STIMULUS 11 148 0.0006642 0.009139
340 REGULATION OF INNATE IMMUNE RESPONSE 19 357 0.0006923 0.009475
341 HISTONE METHYLATION 8 84 0.0007169 0.009782
NumGOOverlapSizeP ValueAdj. P Value
1 RNA BINDING 250 1598 6.736e-153 6.258e-150
2 POLY A RNA BINDING 207 1170 7.429e-133 3.451e-130
3 UNFOLDED PROTEIN BINDING 32 100 5.02e-28 1.166e-25
4 ADENYL NUCLEOTIDE BINDING 110 1514 4.601e-28 1.166e-25
5 RIBONUCLEOTIDE BINDING 121 1860 1.182e-26 2.196e-24
6 STRUCTURAL CONSTITUENT OF RIBOSOME 36 212 4.963e-21 7.684e-19
7 PURINE NTP DEPENDENT HELICASE ACTIVITY 25 98 1.856e-19 2.464e-17
8 HELICASE ACTIVITY 28 153 1.65e-17 1.705e-15
9 ATPASE ACTIVITY 45 427 1.651e-17 1.705e-15
10 RNA HELICASE ACTIVITY 20 67 2.653e-17 2.465e-15
11 ATPASE ACTIVITY COUPLED 37 313 3.442e-16 2.907e-14
12 HYDROLASE ACTIVITY ACTING ON ACID ANHYDRIDES 61 820 5.811e-16 4.499e-14
13 SNORNA BINDING 13 26 3.571e-15 2.552e-13
14 MRNA BINDING 25 155 1.937e-14 1.286e-12
15 TRNA BINDING 14 44 6.186e-13 3.831e-11
16 RRNA BINDING 15 58 2.722e-12 1.58e-10
17 LIGASE ACTIVITY FORMING CARBON OXYGEN BONDS 13 44 1.22e-11 6.668e-10
18 TRANSFERASE ACTIVITY TRANSFERRING ONE CARBON GROUPS 26 225 1.62e-11 8.361e-10
19 HEAT SHOCK PROTEIN BINDING 17 89 1.864e-11 9.115e-10
20 DOUBLE STRANDED RNA BINDING 14 64 1.689e-10 7.844e-09
21 RIBONUCLEOPROTEIN COMPLEX BINDING 16 95 5.257e-10 2.326e-08
22 ENZYME BINDING 81 1737 7.155e-10 3.021e-08
23 TRANSLATION FACTOR ACTIVITY RNA BINDING 15 89 1.813e-09 7.322e-08
24 S ADENOSYLMETHIONINE DEPENDENT METHYLTRANSFERASE ACTIVITY 18 139 3.584e-09 1.387e-07
25 NUCLEOTIDYLTRANSFERASE ACTIVITY 17 131 9.453e-09 3.513e-07
26 TELOMERASE RNA BINDING 7 14 1.001e-08 3.576e-07
27 PRE MRNA BINDING 8 24 4.056e-08 1.396e-06
28 SNRNA BINDING 9 34 5.442e-08 1.806e-06
29 NUCLEASE ACTIVITY 20 209 9.074e-08 2.907e-06
30 ISOMERASE ACTIVITY 17 159 1.715e-07 5.311e-06
31 TRANSLATION INITIATION FACTOR ACTIVITY 10 51 2.149e-07 6.439e-06
32 EXONUCLEASE ACTIVITY 12 80 2.909e-07 8.446e-06
33 INTRAMOLECULAR OXIDOREDUCTASE ACTIVITY TRANSPOSING S S BONDS 7 22 4.236e-07 1.193e-05
34 STRUCTURAL MOLECULE ACTIVITY 39 732 1.22e-06 3.333e-05
35 RNA METHYLTRANSFERASE ACTIVITY 9 48 1.306e-06 3.37e-05
36 MRNA 3 UTR BINDING 9 48 1.306e-06 3.37e-05
37 SINGLE STRANDED DNA BINDING 12 93 1.534e-06 3.852e-05
38 DNA DEPENDENT ATPASE ACTIVITY 11 79 1.95e-06 4.767e-05
39 NUCLEOSIDE DIPHOSPHATE KINASE ACTIVITY 6 18 2.157e-06 5.138e-05
40 RIBONUCLEASE ACTIVITY 12 100 3.343e-06 7.765e-05
41 UBIQUITIN LIKE PROTEIN LIGASE BINDING 20 264 3.69e-06 8.361e-05
42 RNA POLYMERASE I ACTIVITY 5 12 4.459e-06 9.862e-05
43 MACROMOLECULAR COMPLEX BINDING 59 1399 5.213e-06 0.0001126
44 PSEUDOURIDINE SYNTHASE ACTIVITY 5 13 7.108e-06 0.0001501
45 TRNA METHYLTRANSFERASE ACTIVITY 6 22 8.014e-06 0.0001655
46 EXORIBONUCLEASE ACTIVITY 7 34 1.051e-05 0.0002123
47 ADENYLYLTRANSFERASE ACTIVITY 6 24 1.39e-05 0.0002748
48 CHAPERONE BINDING 10 81 1.702e-05 0.0003295
49 PROTEIN METHYLTRANSFERASE ACTIVITY 10 82 1.899e-05 0.0003601
50 INTRAMOLECULAR OXIDOREDUCTASE ACTIVITY 8 53 2.717e-05 0.0005041
51 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 44 992 2.767e-05 0.0005041
52 PHOSPHOTRANSFERASE ACTIVITY PHOSPHATE GROUP AS ACCEPTOR 7 40 3.232e-05 0.0005775
53 N METHYLTRANSFERASE ACTIVITY 10 88 3.543e-05 0.0006211
54 RNA POLYMERASE III ACTIVITY 5 18 4.3e-05 0.0007398
55 HISTONE METHYLTRANSFERASE ACTIVITY 8 58 5.312e-05 0.0008973
56 HSP70 PROTEIN BINDING 6 30 5.453e-05 0.0009045
57 RNA POLYMERASE ACTIVITY 7 44 6.135e-05 0.001
58 NUCLEOBASE CONTAINING COMPOUND KINASE ACTIVITY 7 48 0.0001089 0.001744
59 DNA HELICASE ACTIVITY 7 53 0.0002064 0.00325
60 CHROMATIN BINDING 23 435 0.0002163 0.003349
61 PROTEIN BINDING INVOLVED IN PROTEIN FOLDING 4 14 0.0002341 0.003565
62 ESTROGEN RECEPTOR BINDING 6 40 0.00029 0.004345
63 INTRAMOLECULAR TRANSFERASE ACTIVITY 5 27 0.0003413 0.005033
64 STRUCTURE SPECIFIC DNA BINDING 10 118 0.000414 0.00601
65 ATPASE REGULATOR ACTIVITY 5 30 0.0005692 0.007892
66 STEROID HORMONE RECEPTOR BINDING 8 81 0.0005616 0.007892
67 NF KAPPAB BINDING 5 30 0.0005692 0.007892
68 EXONUCLEASE ACTIVITY ACTIVE WITH EITHER RIBO OR DEOXYRIBONUCLEIC ACIDS AND PRODUCING 5 PHOSPHOMONOESTERS 6 46 0.0006297 0.008603
69 RIBOSOME BINDING 6 47 0.000708 0.009532
NumGOOverlapSizeP ValueAdj. P Value
1 RIBONUCLEOPROTEIN COMPLEX 139 721 3.77e-90 2.202e-87
2 NUCLEOLUS 121 848 4.448e-62 1.299e-59
3 PRERIBOSOME 29 61 1.615e-31 3.144e-29
4 RIBOSOME 42 226 5.609e-26 8.19e-24
5 NUCLEOLAR PART 25 62 4.33e-25 4.214e-23
6 RIBOSOMAL SUBUNIT 36 163 3.878e-25 4.214e-23
7 CYTOSOLIC PART 38 223 3.4e-22 2.837e-20
8 MITOCHONDRION 104 1633 5.653e-22 4.127e-20
9 SPLICEOSOMAL COMPLEX 33 172 4.317e-21 2.801e-19
10 CYTOSOLIC RIBOSOME 27 113 4.193e-20 2.449e-18
11 NUCLEOPLASM PART 58 708 4.286e-17 2.276e-15
12 CATALYTIC STEP 2 SPLICEOSOME 22 89 5.878e-17 2.86e-15
13 MITOCHONDRIAL PART 66 953 1.104e-15 4.962e-14
14 PRERIBOSOME LARGE SUBUNIT PRECURSOR 12 21 4.88e-15 2.036e-13
15 SMALL SUBUNIT PROCESSOME 14 33 5.558e-15 2.164e-13
16 LARGE RIBOSOMAL SUBUNIT 20 95 4.316e-14 1.575e-12
17 MITOCHONDRIAL MATRIX 39 412 8.738e-14 3.002e-12
18 ENVELOPE 67 1090 2.021e-13 6.558e-12
19 NUCLEAR BODY 35 349 3.199e-13 9.833e-12
20 X90S PRERIBOSOME 11 24 1.691e-12 4.938e-11
21 SMALL RIBOSOMAL SUBUNIT 16 68 2.48e-12 6.897e-11
22 CYTOSOLIC LARGE RIBOSOMAL SUBUNIT 15 61 6.056e-12 1.608e-10
23 MITOCHONDRIAL ENVELOPE 47 691 3.822e-11 9.704e-10
24 CHROMOSOME 54 880 6.031e-11 1.468e-09
25 ORGANELLE INNER MEMBRANE 39 525 1.534e-10 3.584e-09
26 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPLEX 13 60 8.675e-10 1.949e-08
27 METHYLTRANSFERASE COMPLEX 15 90 2.13e-09 4.607e-08
28 CYTOSOLIC SMALL RIBOSOMAL SUBUNIT 11 44 3.424e-09 7.142e-08
29 NUCLEOID 11 45 4.439e-09 8.939e-08
30 SMALL NUCLEOLAR RIBONUCLEOPROTEIN COMPLEX 8 20 7.536e-09 1.467e-07
31 CAJAL BODY 11 52 2.283e-08 4.302e-07
32 NUCLEAR CHROMOSOME 34 523 6.581e-08 1.201e-06
33 TELOMERASE HOLOENZYME COMPLEX 7 19 1.329e-07 2.218e-06
34 NUCLEAR SPECK 19 194 1.321e-07 2.218e-06
35 U2 SNRNP 7 19 1.329e-07 2.218e-06
36 EXOSOME RNASE COMPLEX 7 21 2.947e-07 4.78e-06
37 RIBONUCLEOPROTEIN GRANULE 16 148 3.394e-07 5.356e-06
38 U2 TYPE SPLICEOSOMAL COMPLEX 8 31 3.774e-07 5.686e-06
39 MYELIN SHEATH 17 168 3.797e-07 5.686e-06
40 CYTOPLASMIC EXOSOME RNASE COMPLEX 6 15 6.169e-07 9.006e-06
41 U12 TYPE SPLICEOSOMAL COMPLEX 7 26 1.508e-06 2.148e-05
42 NUCLEAR CHROMOSOME TELOMERIC REGION 14 132 2.311e-06 3.214e-05
43 ENDOPLASMIC RETICULUM CHAPERONE COMPLEX 5 11 2.651e-06 3.601e-05
44 CHROMOSOMAL REGION 23 330 2.887e-06 3.831e-05
45 TRANSFERASE COMPLEX 37 703 3.064e-06 3.977e-05
46 CHROMATIN 27 441 4.695e-06 5.961e-05
47 ORGANELLAR RIBOSOME 10 72 5.848e-06 7.266e-05
48 CELL SUBSTRATE JUNCTION 25 398 6.8e-06 8.273e-05
49 DNA DIRECTED RNA POLYMERASE I COMPLEX 5 13 7.108e-06 8.471e-05
50 EXON EXON JUNCTION COMPLEX 6 23 1.063e-05 0.0001242
51 NUCLEAR EXOSOME RNASE COMPLEX 5 15 1.596e-05 0.0001828
52 CATALYTIC COMPLEX 46 1038 1.843e-05 0.000207
53 ORGANELLE ENVELOPE LUMEN 10 83 2.116e-05 0.0002331
54 CHROMOSOME TELOMERIC REGION 14 162 2.484e-05 0.0002687
55 HISTONE METHYLTRANSFERASE COMPLEX 9 71 3.627e-05 0.0003851
56 DNA DIRECTED RNA POLYMERASE III COMPLEX 5 18 4.3e-05 0.0004485
57 NUCLEAR PORE 9 77 6.953e-05 0.0007124
58 CYTOPLASMIC STRESS GRANULE 6 32 8.002e-05 0.0008058
59 PRESPLICEOSOME 5 21 9.645e-05 0.0009547
60 NUCLEAR ENVELOPE 23 416 0.0001127 0.001097
61 NUCLEAR PERIPHERY 11 121 0.0001156 0.001107
62 METHYLOSOME 4 12 0.0001201 0.001131
63 PRECATALYTIC SPLICEOSOME 5 22 0.0001225 0.001135
64 PIGMENT GRANULE 10 103 0.0001362 0.001243
65 ANCHORING JUNCTION 25 489 0.0001954 0.001756
66 MICROTUBULE CYTOSKELETON 43 1068 0.0002939 0.002601
67 U5 SNRNP 4 16 0.0004102 0.003472
68 MLL1 2 COMPLEX 5 28 0.0004077 0.003472
69 U2 TYPE PRESPLICEOSOME 4 16 0.0004102 0.003472
70 U1 SNRNP 4 17 0.0005267 0.004394
71 RNA POLYMERASE COMPLEX 10 122 0.0005397 0.004439
72 RNA POLYMERASE II TRANSCRIPTION FACTOR COMPLEX 9 101 0.0005532 0.004487
73 NUCLEAR TRANSCRIPTION FACTOR COMPLEX 10 127 0.0007395 0.005916
74 COP9 SIGNALOSOME 5 34 0.00103 0.00813

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Endocytosis_hsa04144 12 244 0.01157 0.2309
2 Cellular_senescence_hsa04218 9 160 0.01221 0.2309
3 Ferroptosis_hsa04216 4 40 0.01332 0.2309
4 Cell_cycle_hsa04110 7 124 0.02513 0.3267
5 VEGF_signaling_pathway_hsa04370 4 59 0.0473 0.4919
6 MAPK_signaling_pathway_hsa04010 11 295 0.08191 0.7099
7 ErbB_signaling_pathway_hsa04012 4 85 0.1338 0.8026
8 Gap_junction_hsa04540 4 88 0.1463 0.8026
9 Focal_adhesion_hsa04510 7 199 0.1784 0.8026
10 Necroptosis_hsa04217 6 164 0.1799 0.8026
11 Mitophagy_animal_hsa04137 3 65 0.1898 0.8026
12 FoxO_signaling_pathway_hsa04068 5 132 0.1906 0.8026
13 HIF_1_signaling_pathway_hsa04066 4 100 0.2007 0.8026
14 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 5 139 0.2192 0.8038
15 Adherens_junction_hsa04520 3 72 0.2319 0.8038
16 PI3K_Akt_signaling_pathway_hsa04151 10 352 0.2975 0.8886
17 Notch_signaling_pathway_hsa04330 2 48 0.3047 0.8886
18 Jak_STAT_signaling_pathway_hsa04630 5 162 0.3201 0.8886
19 cGMP_PKG_signaling_pathway_hsa04022 5 163 0.3247 0.8886
20 Apoptosis_hsa04210 4 138 0.3954 1
21 mTOR_signaling_pathway_hsa04150 4 151 0.4624 1
22 p53_signaling_pathway_hsa04115 2 68 0.4681 1
23 Sphingolipid_signaling_pathway_hsa04071 3 118 0.5153 1
24 Regulation_of_actin_cytoskeleton_hsa04810 5 208 0.5271 1
25 Oocyte_meiosis_hsa04114 3 124 0.5487 1
26 NF_kappa_B_signaling_pathway_hsa04064 2 95 0.6482 1
27 Phospholipase_D_signaling_pathway_hsa04072 3 146 0.659 1
28 Wnt_signaling_pathway_hsa04310 3 146 0.659 1
29 cAMP_signaling_pathway_hsa04024 4 198 0.6743 1
30 Hippo_signaling_pathway_hsa04390 3 154 0.694 1
31 Rap1_signaling_pathway_hsa04015 4 206 0.704 1
32 AMPK_signaling_pathway_hsa04152 2 121 0.7726 1
33 Ras_signaling_pathway_hsa04014 4 232 0.7868 1
34 Calcium_signaling_pathway_hsa04020 3 182 0.795 1
35 Autophagy_animal_hsa04140 2 128 0.7988 1
36 Apelin_signaling_pathway_hsa04371 2 137 0.8285 1
37 Tight_junction_hsa04530 2 170 0.9065 1
38 Cytokine_cytokine_receptor_interaction_hsa04060 2 270 0.987 1

Quest ID: 51d6b89c629331d27a003848d26ea48c