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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-125a-5p ARID4A 0.06 0.95785 -0.06 0.92409 miRanda -0.12 0.00166 NA
2 hsa-miR-21-5p ARID4A 0.02 0.99472 -0.06 0.92409 miRNAWalker2 validate -0.11 0.02816 NA
3 hsa-miR-27a-3p ARID4A 0.03 0.98139 -0.06 0.92409 miRNATAP -0.17 0.00022 NA
4 hsa-miR-369-3p ARID4A 0.39 0.2737 -0.06 0.92409 MirTarget; PITA; miRNATAP -0.11 0.00027 NA
5 hsa-miR-23a-3p ATG2B -0.02 0.99063 -0.16 0.81656 MirTarget -0.13 0.02964 NA
6 hsa-miR-140-5p BAZ2B 0.05 0.94453 -0.2 0.78677 PITA; miRanda; miRNATAP -0.15 0.0046 NA
7 hsa-miR-146b-5p BAZ2B 0.09 0.93955 -0.2 0.78677 miRanda -0.14 0.0004 NA
8 hsa-miR-369-3p BAZ2B 0.39 0.2737 -0.2 0.78677 PITA; miRNATAP -0.16 1.0E-5 NA
9 hsa-miR-455-5p BAZ2B 0.01 0.99118 -0.2 0.78677 PITA; miRanda; miRNATAP -0.11 0.00187 NA
10 hsa-miR-92b-3p BAZ2B -0.04 0.96434 -0.2 0.78677 miRNATAP -0.11 0.00092 NA
11 hsa-miR-152-3p BTAF1 0.17 0.87674 -0.1 0.8861 MirTarget -0.15 0.00896 NA
12 hsa-miR-24-3p BTAF1 0.01 0.99378 -0.1 0.8861 miRNATAP -0.21 0.00165 NA
13 hsa-miR-655-3p BTAF1 0.35 0.09787 -0.1 0.8861 MirTarget -0.13 0.00019 NA
14 hsa-let-7e-5p CCNT2 0.09 0.94757 -0.04 0.95568 miRNATAP -0.17 2.0E-5 NA
15 hsa-let-7i-5p CCNT2 -0.06 0.96115 -0.04 0.95568 miRNATAP -0.13 0.00776 NA
16 hsa-miR-132-3p CCNT2 -0.17 0.8559 -0.04 0.95568 miRNATAP -0.12 0.00455 NA
17 hsa-miR-140-3p CCNT2 -0.06 0.96503 -0.04 0.95568 MirTarget; PITA; miRNATAP -0.12 0.00877 NA
18 hsa-miR-22-3p CCNT2 0.17 0.93648 -0.04 0.95568 miRNAWalker2 validate -0.2 1.0E-5 NA
19 hsa-miR-409-3p CCNT2 0.18 0.75399 -0.04 0.95568 miRNATAP -0.1 0.0023 NA
20 hsa-miR-22-3p DNAJC27 0.17 0.93648 -0.15 0.62512 MirTarget -0.2 1.0E-5 NA
21 hsa-miR-27a-3p DNAJC27 0.03 0.98139 -0.15 0.62512 miRNAWalker2 validate; MirTarget; miRNATAP -0.17 4.0E-5 NA
22 hsa-miR-107 FAM13B -0.07 0.96422 -0.07 0.91608 miRanda -0.13 0.02506 NA
23 hsa-miR-30b-5p FAM13B 0.05 0.96089 -0.07 0.91608 mirMAP -0.13 8.0E-5 NA
24 hsa-miR-30c-5p FAM13B -0.05 0.9661 -0.07 0.91608 mirMAP -0.1 0.03629 NA
25 hsa-miR-30e-5p FAM13B -0 0.99878 -0.07 0.91608 mirMAP -0.13 0.01839 NA
26 hsa-miR-32-3p FAM13B 0.17 0.57537 -0.07 0.91608 mirMAP -0.13 0 NA
27 hsa-miR-429 FAM13B -0.24 0.83536 -0.07 0.91608 miRanda -0.13 0 NA
28 hsa-miR-590-3p FAM13B 0.08 0.81071 -0.07 0.91608 miRanda; mirMAP -0.15 0 NA
29 hsa-miR-146b-5p KIAA1109 0.09 0.93955 -0.26 0.7535 miRanda -0.14 0.00064 NA
30 hsa-miR-484 KIAA1109 0.17 0.82965 -0.26 0.7535 miRNAWalker2 validate -0.13 0.00374 NA
31 hsa-miR-496 KIAA1109 0.27 0.22838 -0.26 0.7535 miRanda -0.1 0.00213 NA
32 hsa-let-7i-5p LRIG2 -0.06 0.96115 -0.12 0.78646 MirTarget -0.14 0.01319 NA
33 hsa-miR-106b-5p MAPKBP1 0.01 0.99606 -0.02 0.97074 mirMAP -0.12 0.00282 NA
34 hsa-miR-10a-5p MAPKBP1 -0.1 0.96336 -0.02 0.97074 MirTarget; miRNATAP -0.16 0 NA
35 hsa-miR-141-3p MAPKBP1 0.02 0.98674 -0.02 0.97074 mirMAP -0.11 0.00035 NA
36 hsa-miR-93-5p MAPKBP1 -0.09 0.95565 -0.02 0.97074 mirMAP -0.12 0.0018 NA
37 hsa-let-7a-3p MYO9A -0.07 0.92099 -0.42 0.3754 mirMAP -0.22 5.0E-5 NA
38 hsa-miR-125a-3p MYO9A 0.06 0.84124 -0.42 0.3754 miRanda -0.12 0.00177 NA
39 hsa-miR-140-5p MYO9A 0.05 0.94453 -0.42 0.3754 miRanda -0.25 0.00059 NA
40 hsa-miR-141-3p MYO9A 0.02 0.98674 -0.42 0.3754 TargetScan -0.18 2.0E-5 NA
41 hsa-miR-16-2-3p MYO9A 0.02 0.95282 -0.42 0.3754 mirMAP -0.16 0.00045 NA
42 hsa-miR-17-5p MYO9A 0.02 0.9896 -0.42 0.3754 TargetScan -0.18 6.0E-5 NA
43 hsa-miR-181b-5p MYO9A 0.08 0.94249 -0.42 0.3754 mirMAP -0.13 0.02689 NA
44 hsa-miR-200b-3p MYO9A -0.18 0.90839 -0.42 0.3754 TargetScan -0.12 0.01517 NA
45 hsa-miR-20a-3p MYO9A 0 0.99335 -0.42 0.3754 mirMAP -0.11 0.00148 NA
46 hsa-miR-26a-5p MYO9A -0.05 0.97379 -0.42 0.3754 mirMAP -0.27 0.00562 NA
47 hsa-miR-26b-5p MYO9A 0 0.99905 -0.42 0.3754 mirMAP -0.36 0 NA
48 hsa-miR-27a-3p MYO9A 0.03 0.98139 -0.42 0.3754 miRNAWalker2 validate -0.36 1.0E-5 NA
49 hsa-miR-30b-5p MYO9A 0.05 0.96089 -0.42 0.3754 mirMAP -0.29 0 NA
50 hsa-miR-30c-5p MYO9A -0.05 0.9661 -0.42 0.3754 mirMAP -0.27 0.0001 NA
51 hsa-miR-335-3p MYO9A -0.17 0.87115 -0.42 0.3754 mirMAP -0.12 0.00691 NA
52 hsa-miR-429 MYO9A -0.24 0.83536 -0.42 0.3754 miRanda -0.15 0.00011 NA
53 hsa-miR-495-3p MYO9A 0.18 0.59665 -0.42 0.3754 mirMAP -0.14 0.02558 NA
54 hsa-miR-500a-5p MYO9A -0.12 0.73708 -0.42 0.3754 mirMAP -0.13 0.0018 NA
55 hsa-miR-590-3p MYO9A 0.08 0.81071 -0.42 0.3754 miRanda; mirMAP -0.19 0 NA
56 hsa-miR-590-5p MYO9A -0.06 0.89349 -0.42 0.3754 miRanda -0.23 0 NA
57 hsa-miR-940 MYO9A -0.08 0.83358 -0.42 0.3754 miRNATAP -0.11 0.00214 NA
58 hsa-miR-96-5p MYO9A 0.08 0.88529 -0.42 0.3754 TargetScan -0.23 0 NA
59 hsa-miR-21-5p NR2C2 0.02 0.99472 -0.1 0.89483 miRNAWalker2 validate -0.12 0.01096 NA
60 hsa-let-7a-3p SENP7 -0.07 0.92099 -0.11 0.82326 miRNAWalker2 validate -0.12 0.00271 NA
61 hsa-miR-148b-5p SENP7 0.05 0.81025 -0.11 0.82326 MirTarget -0.11 0.00156 NA
62 hsa-miR-186-5p SENP7 -0.1 0.92207 -0.11 0.82326 MirTarget; mirMAP -0.11 0.03495 NA
63 hsa-miR-221-3p SENP7 0.06 0.95442 -0.11 0.82326 MirTarget -0.11 0.01345 NA
64 hsa-miR-222-3p SENP7 0.07 0.93415 -0.11 0.82326 MirTarget -0.12 0.00434 NA
65 hsa-miR-576-5p SENP7 -0.06 0.88424 -0.11 0.82326 MirTarget; PITA -0.1 0.00623 NA
66 hsa-miR-590-3p SENP7 0.08 0.81071 -0.11 0.82326 MirTarget; PITA; miRanda; miRNATAP -0.11 0.0002 NA
67 hsa-miR-942-5p SENP7 -0.03 0.94231 -0.11 0.82326 MirTarget -0.12 0.00013 NA
68 hsa-miR-222-3p YLPM1 0.07 0.93415 -0.18 0.83826 miRNAWalker2 validate -0.14 9.0E-5 NA
69 hsa-miR-542-3p YLPM1 0.12 0.90336 -0.18 0.83826 miRNATAP -0.12 0.00206 NA
70 hsa-miR-21-5p ZDHHC17 0.02 0.99472 0 0.99992 miRNATAP -0.17 0.0002 NA
71 hsa-miR-369-3p ZDHHC17 0.39 0.2737 0 0.99992 MirTarget; PITA; miRNATAP -0.12 4.0E-5 NA
72 hsa-miR-889-3p ZDHHC17 0.2 0.71678 0 0.99992 MirTarget -0.11 0.00725 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 CECR7 hsa-let-7a-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-200b-3p;hsa-miR-20a-3p;hsa-miR-26b-5p;hsa-miR-27a-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-335-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-940 15 MYO9A Sponge network -0.206 0.73331 -0.424 0.3754 0.256

Quest ID: 53fa3e56a67a058df4d7ae56746513c9