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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-130a-3p NRP1 0.01 0.93453 -0.11 0.41779 miRNATAP -0.18 0.00023 26573160 NRP1 is targeted by miR 130a and miR 130b and is associated with multidrug resistance in epithelial ovarian cancer based on integrated gene network analysis
2 hsa-miR-133b NRP1 1.64 0 -0.11 0.41779 miRanda -0.15 0 NA
3 hsa-miR-139-5p NRP1 0.25 0.04065 -0.11 0.41779 PITA; miRanda -0.14 0.00259 NA
4 hsa-miR-141-3p NRP1 -1.8 0 -0.11 0.41779 TargetScan; miRNATAP -0.12 0.00065 NA
5 hsa-miR-148a-3p NRP1 -1.85 0 -0.11 0.41779 miRNATAP -0.2 0 26967387 Mechanistically miR-148a appears to suppress the extravasation process of cancer cells likely by targeting two genes WNT1 and NRP1 in a cell non-autonomous manner
6 hsa-miR-186-5p NRP1 -0.57 0 -0.11 0.41779 miRNAWalker2 validate; mirMAP; miRNATAP -0.19 0.00921 NA
7 hsa-miR-214-3p NRP1 -0.25 0.05575 -0.11 0.41779 miRNATAP -0.15 0.00097 NA
8 hsa-miR-30a-5p NRP1 -0.51 0 -0.11 0.41779 mirMAP; miRNATAP -0.19 0.00027 NA
9 hsa-miR-30b-5p NRP1 -1.17 0 -0.11 0.41779 mirMAP -0.13 0.00248 NA
10 hsa-miR-30c-5p NRP1 -0.75 0 -0.11 0.41779 mirMAP; miRNATAP -0.29 0 NA
11 hsa-miR-30e-5p NRP1 0.04 0.61092 -0.11 0.41779 mirMAP -0.23 0.00128 NA
12 hsa-miR-320a NRP1 -1 0 -0.11 0.41779 PITA; miRanda; miRNATAP -0.12 0.01833 22134529 miR-320a directly binds to the 3'UTR of neuropilin 1 NRP-1 a protein that functions as a co-receptor of vascular epithelial growth factor
13 hsa-miR-324-5p NRP1 -0.54 2.0E-5 -0.11 0.41779 miRanda -0.12 0.00975 NA
14 hsa-miR-361-5p NRP1 -0.65 0 -0.11 0.41779 miRanda; miRNATAP -0.36 1.0E-5 NA
15 hsa-miR-374a-3p NRP1 -0.61 0 -0.11 0.41779 miRNATAP -0.14 0.02516 NA
16 hsa-miR-582-5p NRP1 -0.31 0.04027 -0.11 0.41779 PITA; miRNATAP -0.15 7.0E-5 NA
17 hsa-miR-590-3p NRP1 -0.58 0 -0.11 0.41779 PITA; miRanda; mirMAP -0.1 0.02839 NA
18 hsa-miR-590-5p NRP1 -0.78 0 -0.11 0.41779 miRanda -0.12 0.00685 NA
19 hsa-miR-664a-3p NRP1 -0.77 0 -0.11 0.41779 mirMAP -0.21 0.00023 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF CELLULAR COMPONENT MOVEMENT 15 771 8.539e-13 3.973e-09
2 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 10 262 1.726e-11 4.015e-08
3 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 15 1021 4.674e-11 7.249e-08
4 NEGATIVE REGULATION OF CELL DEVELOPMENT 10 303 7.215e-11 7.877e-08
5 REGULATION OF NEURON DIFFERENTIATION 12 554 8.464e-11 7.877e-08
6 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 13 750 1.801e-10 1.197e-07
7 RESPONSE TO EXTERNAL STIMULUS 18 1821 1.706e-10 1.197e-07
8 TAXIS 11 464 2.352e-10 1.368e-07
9 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 17 1672 4.639e-10 2.398e-07
10 NEGATIVE REGULATION OF LOCOMOTION 9 263 5.372e-10 2.499e-07
11 REGULATION OF CELL DEVELOPMENT 13 836 6.817e-10 2.884e-07
12 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 12 684 9.433e-10 3.657e-07
13 MESENCHYME DEVELOPMENT 8 190 1.082e-09 3.785e-07
14 TISSUE DEVELOPMENT 16 1518 1.139e-09 3.785e-07
15 REGULATION OF NEURON PROJECTION DEVELOPMENT 10 408 1.302e-09 4.04e-07
16 REGULATION OF CELL PROJECTION ORGANIZATION 11 558 1.643e-09 4.779e-07
17 LOCOMOTION 14 1114 1.967e-09 5.099e-07
18 NEURON PROJECTION GUIDANCE 8 205 1.972e-09 5.099e-07
19 MESENCHYMAL CELL DIFFERENTIATION 7 134 2.977e-09 7.289e-07
20 NEUROGENESIS 15 1402 3.837e-09 8.927e-07
21 SEMAPHORIN PLEXIN SIGNALING PATHWAY 5 36 4.417e-09 9.787e-07
22 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 13 983 4.858e-09 1.028e-06
23 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 12 801 5.599e-09 1.133e-06
24 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 6 84 6.741e-09 1.307e-06
25 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 9 368 1.015e-08 1.889e-06
26 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 10 513 1.166e-08 2.086e-06
27 NEURON DIFFERENTIATION 12 874 1.482e-08 2.554e-06
28 REGULATION OF CELL SIZE 7 172 1.69e-08 2.808e-06
29 GLAND DEVELOPMENT 9 395 1.872e-08 2.969e-06
30 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 8 274 1.914e-08 2.969e-06
31 NEURON PROJECTION DEVELOPMENT 10 545 2.068e-08 3.007e-06
32 CELLULAR COMPONENT MORPHOGENESIS 12 900 2.052e-08 3.007e-06
33 NEURON PROJECTION MORPHOGENESIS 9 402 2.178e-08 3.071e-06
34 NEURAL CREST CELL MIGRATION 5 51 2.701e-08 3.696e-06
35 RESPONSE TO WOUNDING 10 563 2.81e-08 3.736e-06
36 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 13 1142 2.911e-08 3.762e-06
37 POSITIVE REGULATION OF LOCOMOTION 9 420 3.174e-08 3.992e-06
38 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 7 191 3.48e-08 4.056e-06
39 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 14 1395 3.487e-08 4.056e-06
40 STEM CELL DIFFERENTIATION 7 190 3.357e-08 4.056e-06
41 CELL DEVELOPMENT 14 1426 4.599e-08 5.219e-06
42 CARDIOVASCULAR SYSTEM DEVELOPMENT 11 788 5.813e-08 6.216e-06
43 NEGATIVE REGULATION OF CELL DIFFERENTIATION 10 609 5.878e-08 6.216e-06
44 CIRCULATORY SYSTEM DEVELOPMENT 11 788 5.813e-08 6.216e-06
45 REGULATION OF CELL DIFFERENTIATION 14 1492 8.11e-08 8.386e-06
46 CELL PART MORPHOGENESIS 10 633 8.438e-08 8.535e-06
47 NEGATIVE REGULATION OF AXONOGENESIS 5 65 9.333e-08 9.239e-06
48 ORGAN MORPHOGENESIS 11 841 1.125e-07 1.091e-05
49 NEGATIVE REGULATION OF AXON GUIDANCE 4 27 1.34e-07 1.272e-05
50 RESPONSE TO ALCOHOL 8 362 1.638e-07 1.494e-05
51 CENTRAL NERVOUS SYSTEM DEVELOPMENT 11 872 1.621e-07 1.494e-05
52 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 6 144 1.715e-07 1.534e-05
53 NEURON DEVELOPMENT 10 687 1.807e-07 1.586e-05
54 NEURAL CREST CELL DIFFERENTIATION 5 75 1.926e-07 1.659e-05
55 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 13 1360 2.255e-07 1.908e-05
56 TISSUE MORPHOGENESIS 9 533 2.413e-07 1.974e-05
57 HEAD DEVELOPMENT 10 709 2.419e-07 1.974e-05
58 AMEBOIDAL TYPE CELL MIGRATION 6 154 2.551e-07 2.047e-05
59 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 11 926 2.963e-07 2.337e-05
60 MUSCLE TISSUE DEVELOPMENT 7 275 4.165e-07 3.23e-05
61 REGULATION OF AXONOGENESIS 6 168 4.261e-07 3.25e-05
62 NEGATIVE REGULATION OF AXON EXTENSION 4 38 5.56e-07 4.172e-05
63 REGULATION OF DEVELOPMENTAL GROWTH 7 289 5.817e-07 4.296e-05
64 REGULATION OF AXON GUIDANCE 4 39 6.187e-07 4.498e-05
65 RHYTHMIC PROCESS 7 298 7.146e-07 5.116e-05
66 POSITIVE REGULATION OF CELL PROLIFERATION 10 814 8.583e-07 5.96e-05
67 REGULATION OF EXTENT OF CELL GROWTH 5 101 8.555e-07 5.96e-05
68 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 12 1275 9.038e-07 6.185e-05
69 CELL MOTILITY 10 835 1.082e-06 7.191e-05
70 LOCALIZATION OF CELL 10 835 1.082e-06 7.191e-05
71 HEART DEVELOPMENT 8 466 1.108e-06 7.259e-05
72 OVULATION CYCLE 5 113 1.493e-06 9.652e-05
73 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 7 337 1.624e-06 0.0001021
74 REGULATION OF CELLULAR COMPONENT SIZE 7 337 1.624e-06 0.0001021
75 RESPONSE TO STEROID HORMONE 8 497 1.792e-06 0.0001097
76 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 5 117 1.774e-06 0.0001097
77 NEGATIVE REGULATION OF CHEMOTAXIS 4 51 1.852e-06 0.0001119
78 EMBRYO DEVELOPMENT 10 894 2.005e-06 0.0001196
79 CELL PROJECTION ORGANIZATION 10 902 2.173e-06 0.000128
80 FOREBRAIN DEVELOPMENT 7 357 2.381e-06 0.0001385
81 RESPONSE TO ORGANIC CYCLIC COMPOUND 10 917 2.52e-06 0.0001447
82 CARDIAC RIGHT VENTRICLE MORPHOGENESIS 3 16 2.707e-06 0.0001517
83 BRANCHING INVOLVED IN SALIVARY GLAND MORPHOGENESIS 3 16 2.707e-06 0.0001517
84 REGULATION OF VASCULATURE DEVELOPMENT 6 233 2.868e-06 0.0001589
85 NEGATIVE REGULATION OF GROWTH 6 236 3.088e-06 0.000169
86 ANATOMICAL STRUCTURE ARRANGEMENT 3 17 3.283e-06 0.0001776
87 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 10 957 3.692e-06 0.0001974
88 RETINAL GANGLION CELL AXON GUIDANCE 3 18 3.935e-06 0.0002057
89 REGULATION OF CELL MORPHOGENESIS 8 552 3.903e-06 0.0002057
90 KIDNEY VASCULATURE DEVELOPMENT 3 19 4.667e-06 0.0002386
91 RENAL SYSTEM VASCULATURE DEVELOPMENT 3 19 4.667e-06 0.0002386
92 REGULATION OF CELL PROLIFERATION 12 1496 4.838e-06 0.0002447
93 MORPHOGENESIS OF AN EPITHELIUM 7 400 5.036e-06 0.000252
94 RESPONSE TO ESTRADIOL 5 146 5.266e-06 0.0002607
95 GROWTH 7 410 5.921e-06 0.00029
96 RESPONSE TO ABIOTIC STIMULUS 10 1024 6.732e-06 0.0003263
97 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 4 74 8.288e-06 0.0003915
98 MUSCLE STRUCTURE DEVELOPMENT 7 432 8.329e-06 0.0003915
99 RESPONSE TO DRUG 7 431 8.204e-06 0.0003915
100 CELLULAR GLUCOSE HOMEOSTASIS 4 75 8.744e-06 0.0004028
101 POSITIVE REGULATION OF CELL DIFFERENTIATION 9 823 8.715e-06 0.0004028
102 REGULATION OF EPITHELIAL CELL PROLIFERATION 6 285 9.109e-06 0.0004155
103 DIENCEPHALON DEVELOPMENT 4 77 9.711e-06 0.0004387
104 REGULATION OF EPITHELIAL CELL MIGRATION 5 166 9.842e-06 0.0004403
105 MORPHOGENESIS OF A BRANCHING STRUCTURE 5 167 1.013e-05 0.000449
106 RESPONSE TO CARBOHYDRATE 5 168 1.043e-05 0.0004579
107 REGULATION OF GROWTH 8 633 1.064e-05 0.0004594
108 ANGIOGENESIS 6 293 1.066e-05 0.0004594
109 NEGATIVE REGULATION OF NEURON DEATH 5 171 1.137e-05 0.0004852
110 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 12 1656 1.372e-05 0.0005805
111 REGULATION OF ANATOMICAL STRUCTURE SIZE 7 472 1.479e-05 0.0005934
112 RESPONSE TO OXYGEN CONTAINING COMPOUND 11 1381 1.453e-05 0.0005934
113 VASCULATURE DEVELOPMENT 7 469 1.42e-05 0.0005934
114 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 9 876 1.438e-05 0.0005934
115 REGULATION OF CHEMOTAXIS 5 180 1.457e-05 0.0005934
116 POSITIVE REGULATION OF CELL DEVELOPMENT 7 472 1.479e-05 0.0005934
117 REGIONALIZATION 6 311 1.496e-05 0.0005948
118 RESPONSE TO KETONE 5 182 1.536e-05 0.0006059
119 RESPONSE TO LIPID 9 888 1.602e-05 0.0006266
120 RESPONSE TO ACID CHEMICAL 6 319 1.726e-05 0.0006632
121 SEGMENTATION 4 89 1.726e-05 0.0006632
122 RESPONSE TO ARSENIC CONTAINING SUBSTANCE 3 29 1.739e-05 0.0006632
123 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 8 689 1.965e-05 0.0007433
124 DEVELOPMENTAL GROWTH 6 333 2.2e-05 0.0008254
125 RESPONSE TO ENDOGENOUS STIMULUS 11 1450 2.298e-05 0.0008553
126 SALIVARY GLAND DEVELOPMENT 3 32 2.352e-05 0.0008616
127 ENDOCARDIAL CUSHION DEVELOPMENT 3 32 2.352e-05 0.0008616
128 GLAND MORPHOGENESIS 4 97 2.426e-05 0.0008817
129 NEURON RECOGNITION 3 33 2.584e-05 0.000932
130 EPITHELIUM DEVELOPMENT 9 945 2.625e-05 0.0009394
131 REGULATION OF CELL DEATH 11 1472 2.645e-05 0.0009394
132 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 4 103 3.072e-05 0.001083
133 POSITIVE CHEMOTAXIS 3 36 3.369e-05 0.001179
134 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 5 216 3.498e-05 0.001214
135 NEGATIVE REGULATION OF GLIOGENESIS 3 37 3.662e-05 0.001244
136 BLOOD VESSEL MORPHOGENESIS 6 364 3.624e-05 0.001244
137 RESPONSE TO ESTROGEN 5 218 3.655e-05 0.001244
138 POSITIVE REGULATION OF CELL COMMUNICATION 11 1532 3.833e-05 0.001292
139 TUBE DEVELOPMENT 7 552 4.034e-05 0.00135
140 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 12 1848 4.13e-05 0.001373
141 CELL CELL SIGNALING 8 767 4.229e-05 0.001395
142 NEGATIVE CHEMOTAXIS 3 39 4.297e-05 0.001398
143 NEGATIVE REGULATION OF MITOCHONDRION ORGANIZATION 3 39 4.297e-05 0.001398
144 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 4 115 4.733e-05 0.001529
145 REGULATION OF CELL GROWTH 6 391 5.397e-05 0.001732
146 CRANIAL NERVE DEVELOPMENT 3 43 5.775e-05 0.00184
147 REGULATION OF ORGAN MORPHOGENESIS 5 242 6.006e-05 0.001901
148 EXOCRINE SYSTEM DEVELOPMENT 3 45 6.624e-05 0.002076
149 EMBRYONIC ORGAN DEVELOPMENT 6 406 6.648e-05 0.002076
150 REPRODUCTIVE SYSTEM DEVELOPMENT 6 408 6.832e-05 0.002119
151 POSITIVE REGULATION OF CELL DEATH 7 605 7.2e-05 0.002219
152 REGULATION OF NEURON DEATH 5 252 7.275e-05 0.002227
153 PATTERN SPECIFICATION PROCESS 6 418 7.808e-05 0.002375
154 RETINA DEVELOPMENT IN CAMERA TYPE EYE 4 131 7.864e-05 0.002376
155 RESPONSE TO AXON INJURY 3 48 8.045e-05 0.0024
156 DIGESTIVE TRACT MORPHOGENESIS 3 48 8.045e-05 0.0024
157 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 4 135 8.837e-05 0.002619
158 CELLULAR RESPONSE TO ABIOTIC STIMULUS 5 263 8.899e-05 0.002621
159 AGING 5 264 9.059e-05 0.002651
160 SEX DIFFERENTIATION 5 266 9.387e-05 0.00273
161 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 6 437 9.971e-05 0.002882
162 RESPONSE TO EXTRACELLULAR STIMULUS 6 441 0.0001048 0.003009
163 NEGATIVE REGULATION OF CELL PROLIFERATION 7 643 0.0001054 0.003009
164 NEGATIVE REGULATION OF AUTOPHAGY 3 53 0.0001083 0.003073
165 CARDIAC CHAMBER DEVELOPMENT 4 144 0.0001135 0.003199
166 EMBRYONIC ORGAN MORPHOGENESIS 5 279 0.0001174 0.003292
167 RESPONSE TO HORMONE 8 893 0.0001229 0.003425
168 CELLULAR RESPONSE TO LIPID 6 457 0.0001274 0.003528
169 CELL PROLIFERATION 7 672 0.0001387 0.003818
170 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 6 465 0.00014 0.003833
171 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 4 154 0.000147 0.003999
172 WOUND HEALING 6 470 0.0001484 0.004016
173 NEGATIVE REGULATION OF CELLULAR CATABOLIC PROCESS 4 156 0.0001545 0.004154
174 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 3 60 0.0001569 0.004196
175 NEGATIVE REGULATION OF CELL COMMUNICATION 9 1192 0.0001586 0.004216
176 NEGATIVE REGULATION OF GLIAL CELL PROLIFERATION 2 11 0.000162 0.004267
177 UROGENITAL SYSTEM DEVELOPMENT 5 299 0.0001623 0.004267
178 RESPONSE TO INORGANIC SUBSTANCE 6 479 0.0001646 0.004284
179 OVARIAN FOLLICLE DEVELOPMENT 3 61 0.0001648 0.004284
180 CARDIAC VENTRICLE MORPHOGENESIS 3 62 0.000173 0.004447
181 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 5 303 0.0001727 0.004447
182 POSITIVE REGULATION OF NEURON DIFFERENTIATION 5 306 0.0001808 0.004621
183 NEURON PROJECTION EXTENSION INVOLVED IN NEURON PROJECTION GUIDANCE 2 12 0.0001942 0.004885
184 AXON EXTENSION INVOLVED IN AXON GUIDANCE 2 12 0.0001942 0.004885
185 HEART FORMATION 2 12 0.0001942 0.004885
186 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 4 166 0.0001961 0.004893
187 EPITHELIAL CELL DIFFERENTIATION 6 495 0.0001966 0.004893
188 NEGATIVE REGULATION OF CELL GROWTH 4 170 0.0002148 0.00526
189 GLUCOSE HOMEOSTASIS 4 170 0.0002148 0.00526
190 CARBOHYDRATE HOMEOSTASIS 4 170 0.0002148 0.00526
191 MULTICELLULAR ORGANISMAL RESPONSE TO STRESS 3 68 0.0002276 0.005369
192 CELLULAR RESPONSE TO THYROID HORMONE STIMULUS 2 13 0.0002293 0.005369
193 ORGAN GROWTH 3 68 0.0002276 0.005369
194 NERVE DEVELOPMENT 3 68 0.0002276 0.005369
195 REGULATION OF SYSTEM PROCESS 6 507 0.0002238 0.005369
196 REGULATION OF CELL SUBSTRATE ADHESION 4 173 0.0002296 0.005369
197 SEMAPHORIN PLEXIN SIGNALING PATHWAY INVOLVED IN NEURON PROJECTION GUIDANCE 2 13 0.0002293 0.005369
198 MESENCHYMAL CELL PROLIFERATION 2 13 0.0002293 0.005369
199 GANGLION DEVELOPMENT 2 13 0.0002293 0.005369
200 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 3 70 0.000248 0.00577
201 SPECIFICATION OF ORGAN IDENTITY 2 14 0.0002672 0.006155
202 ATRIAL SEPTUM MORPHOGENESIS 2 14 0.0002672 0.006155
203 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 8 1008 0.0002821 0.006467
204 REPRODUCTION 9 1297 0.000299 0.00682
205 POSITIVE REGULATION OF RESPONSE TO STIMULUS 11 1929 0.0003054 0.006889
206 REGULATION OF MEMBRANE POTENTIAL 5 343 0.0003065 0.006889
207 BLASTODERM SEGMENTATION 2 15 0.000308 0.006889
208 REGULATION OF CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS 2 15 0.000308 0.006889
209 MULTICELLULAR ORGANISM REPRODUCTION 7 768 0.0003145 0.007002
210 DEVELOPMENTAL CELL GROWTH 3 77 0.0003286 0.007282
211 RESPONSE TO NUTRIENT 4 191 0.0003348 0.007382
212 REGULATION OF NEURON APOPTOTIC PROCESS 4 192 0.0003415 0.007494
213 DENDRITE DEVELOPMENT 3 79 0.0003544 0.007742
214 NEGATIVE REGULATION OF VASCULATURE DEVELOPMENT 3 80 0.0003678 0.007997
215 RESPIRATORY SYSTEM DEVELOPMENT 4 197 0.0003764 0.008146
216 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 4 199 0.0003911 0.008425
217 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 7 799 0.0003996 0.00849
218 NEGATIVE REGULATION OF STEM CELL PROLIFERATION 2 17 0.000398 0.00849
219 PARASYMPATHETIC NERVOUS SYSTEM DEVELOPMENT 2 17 0.000398 0.00849
220 REGULATION OF ION HOMEOSTASIS 4 201 0.0004062 0.00859
221 NEGATIVE REGULATION OF CATABOLIC PROCESS 4 203 0.0004216 0.008878
222 CARDIAC SEPTUM DEVELOPMENT 3 85 0.0004395 0.009212
223 ATRIAL SEPTUM DEVELOPMENT 2 18 0.0004473 0.009291
224 KIDNEY MESENCHYME DEVELOPMENT 2 18 0.0004473 0.009291
225 LIPID MODIFICATION 4 210 0.0004792 0.00991
NumGOOverlapSizeP ValueAdj. P Value
1 RECEPTOR BINDING 14 1476 7.086e-08 6.583e-05
2 NEUROPILIN BINDING 3 15 2.202e-06 0.001023
3 HEPARIN BINDING 5 157 7.506e-06 0.001743
4 SEMAPHORIN RECEPTOR BINDING 3 22 7.39e-06 0.001743
5 CHEMOREPELLENT ACTIVITY 3 27 1.395e-05 0.002592
6 GLYCOSAMINOGLYCAN BINDING 5 205 2.724e-05 0.004217
7 SULFUR COMPOUND BINDING 5 234 5.121e-05 0.006796
NumGOOverlapSizeP ValueAdj. P Value
1 EXTRACELLULAR SPACE 13 1376 2.582e-07 0.0001508
2 PROTEINACEOUS EXTRACELLULAR MATRIX 7 356 2.337e-06 0.0006824
3 EXTRACELLULAR MATRIX 7 426 7.603e-06 0.00148
4 BASEMENT MEMBRANE 4 93 2.054e-05 0.002999
5 EXTRACELLULAR MATRIX COMPONENT 4 125 6.553e-05 0.007654

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 PI3K_Akt_signaling_pathway_hsa04151 5 352 0.0003452 0.01795
2 Ras_signaling_pathway_hsa04014 4 232 0.0006965 0.01811
3 Autophagy_animal_hsa04140 3 128 0.001443 0.02501
4 Wnt_signaling_pathway_hsa04310 3 146 0.002102 0.02732
5 Cellular_senescence_hsa04218 3 160 0.002725 0.02835
6 Focal_adhesion_hsa04510 3 199 0.005024 0.03337
7 Rap1_signaling_pathway_hsa04015 3 206 0.00553 0.03337
8 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.00568 0.03337
9 Mitophagy_animal_hsa04137 2 65 0.005775 0.03337
10 MAPK_signaling_pathway_hsa04010 3 295 0.01468 0.07631
11 Sphingolipid_signaling_pathway_hsa04071 2 118 0.01809 0.08551
12 Apelin_signaling_pathway_hsa04371 2 137 0.02391 0.09826
13 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.02457 0.09826
14 Cell_adhesion_molecules_.CAMs._hsa04514 2 145 0.02657 0.09868
15 Tight_junction_hsa04530 2 170 0.03558 0.1233
16 cAMP_signaling_pathway_hsa04024 2 198 0.04687 0.1523

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 RP11-815I9.4 hsa-miR-130a-3p;hsa-miR-148a-3p;hsa-miR-186-5p;hsa-miR-214-3p;hsa-miR-30a-5p;hsa-miR-30c-5p;hsa-miR-320a;hsa-miR-324-5p;hsa-miR-590-5p;hsa-miR-664a-3p 10 NRP1 Sponge network 0.348 0.02944 -0.111 0.41779 0.39
2 OIP5-AS1 hsa-miR-130a-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-186-5p;hsa-miR-214-3p;hsa-miR-30a-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-320a;hsa-miR-324-5p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-664a-3p 14 NRP1 Sponge network 0.421 0 -0.111 0.41779 0.389
3 BHLHE40-AS1 hsa-miR-130a-3p;hsa-miR-139-5p;hsa-miR-148a-3p;hsa-miR-186-5p;hsa-miR-30a-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30e-5p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p 11 NRP1 Sponge network 0.37 0.02438 -0.111 0.41779 0.36
4 SNHG14 hsa-miR-130a-3p;hsa-miR-186-5p;hsa-miR-214-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30e-5p;hsa-miR-320a;hsa-miR-324-5p;hsa-miR-361-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-664a-3p 12 NRP1 Sponge network 0.051 0.64448 -0.111 0.41779 0.268

Quest ID: 56a2860d299fb7050edb0cb38ea67a1f