Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

GRN in network:

Notice: IE browser need to manually refresh (F5) this page after resetting the network.

This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-199a-5p A2ML1 -0.36 0.04351 -1.64 0.00028 miRanda -0.44 7.0E-5 NA
2 hsa-miR-199a-5p ABCA13 -0.36 0.04351 0.72 0.08476 miRanda -0.2 0.04305 NA
3 hsa-miR-199a-5p ABI1 -0.36 0.04351 -0.24 0.0098 miRanda -0.12 0 NA
4 hsa-miR-148a-5p ABL2 -1 0 1.1 0 miRNATAP -0.11 9.0E-5 NA
5 hsa-miR-30a-5p ABL2 -1.8 0 1.1 0 mirMAP; miRNATAP -0.18 0 NA
6 hsa-miR-30a-5p ACAP2 -1.8 0 0.11 0.40427 MirTarget; miRNATAP -0.1 0.00116 NA
7 hsa-miR-199a-5p ACER2 -0.36 0.04351 -0.24 0.26552 miRanda -0.23 2.0E-5 NA
8 hsa-miR-199a-5p ACOT11 -0.36 0.04351 -0.47 0.01215 mirMAP -0.14 0.00269 NA
9 hsa-miR-30a-5p ACTN1 -1.8 0 0.8 0 miRNATAP -0.23 0 NA
10 hsa-miR-148a-5p ACTR1A -1 0 -0.07 0.3734 miRNAWalker2 validate -0.11 0 NA
11 hsa-miR-30a-5p ACVR1 -1.8 0 0.7 0 MirTarget; miRNATAP -0.18 0 NA
12 hsa-miR-155-5p ACVR2A 0.53 0.00249 -0.89 0 miRNATAP -0.11 0.00016 NA
13 hsa-miR-193b-5p ACVR2A 1.1 0 -0.89 0 MirTarget -0.31 0 NA
14 hsa-miR-155-5p ADAM10 0.53 0.00249 0.48 0.00248 miRNAWalker2 validate -0.15 0.00015 NA
15 hsa-miR-193b-5p ADAM22 1.1 0 -0.46 0.16333 MirTarget -0.7 0 NA
16 hsa-miR-30a-5p ADAMTS6 -1.8 0 2.34 0 MirTarget; miRNATAP -0.17 0.00471 NA
17 hsa-miR-193b-5p ADHFE1 1.1 0 -2 0 MirTarget -0.36 0 NA
18 hsa-miR-199a-5p ADK -0.36 0.04351 0.22 0.03771 miRanda -0.11 1.0E-5 NA
19 hsa-miR-199a-5p ADNP2 -0.36 0.04351 -0.05 0.62164 miRanda -0.12 0 NA
20 hsa-miR-30a-5p AFAP1L2 -1.8 0 1.01 0 MirTarget; miRNATAP -0.22 0 NA
21 hsa-miR-148a-5p AGPAT4 -1 0 0.57 0.00219 mirMAP -0.3 0 NA
22 hsa-miR-199a-5p AGPAT5 -0.36 0.04351 -0.05 0.6317 miRanda -0.12 2.0E-5 NA
23 hsa-miR-155-5p AGTR1 0.53 0.00249 -1.69 0 miRNAWalker2 validate; miRTarBase -0.37 2.0E-5 22525818 MicroRNA-155 miR-155 is one of the micro RNAs miRNA most consistently involved in neoplastic diseases and it is known to repress the angiotensin II type 1 receptor AGTR1; The aim of the present study was to evaluate the expressions of miR-155 and AGTR1 and to clarify the potential efficacy of anti-miR-155 alone and in combination with AGTR1 blocker losartan in endometrial cancers; Expressions of miR-155 and AGTR1 were evaluated using real-time PCR and immunohistochemistry; miR-155 was over-expressed and AGTR1 was underexpressed in endometrial carcinoma tissues; We checked that abolishing the function of miR-155 and AGTR1 by anti-miR-155 or losartan inhibited cell survival of endometrial carcinoma cells respectively and furthermore combined treatment showed synergistic effects; In this study we characterized the expressions of miR-155 and AGTR1 in endometrial tissues; The combined treatment with anti-miR-155 and losartan has a synergistic antiproliferative effect and an improved understanding is required to clarify whether miR-155 and AGTR1 can be used as a novel therapeutic target in endometrial cancer
24 hsa-miR-155-5p AHCYL2 0.53 0.00249 -0.77 0 miRNATAP -0.11 0.00098 NA
25 hsa-miR-30a-5p AHNAK -1.8 0 -0.84 0 miRNATAP -0.1 0.00711 NA
26 hsa-miR-193b-5p AIF1L 1.1 0 -2.25 0 MirTarget -0.15 0.01876 NA
27 hsa-miR-193b-5p AK3 1.1 0 -0.85 0 MirTarget -0.13 2.0E-5 NA
28 hsa-miR-199a-5p AKNA -0.36 0.04351 0.23 0.10999 miRanda -0.1 0.00391 NA
29 hsa-miR-148a-5p AKR1C1 -1 0 0.01 0.97742 mirMAP -0.2 0.02663 NA
30 hsa-miR-30a-5p AKR1C1 -1.8 0 0.01 0.97742 mirMAP -0.39 7.0E-5 NA
31 hsa-miR-155-5p AKR1C3 0.53 0.00249 0.34 0.34929 miRNAWalker2 validate -0.66 0 NA
32 hsa-miR-30a-5p AMMECR1 -1.8 0 0.41 0.0038 miRNATAP -0.29 0 NA
33 hsa-miR-199a-5p AMPD3 -0.36 0.04351 0.07 0.62369 miRanda -0.18 0 NA
34 hsa-miR-148a-5p ANGPT2 -1 0 1.61 0 mirMAP -0.11 0.00532 NA
35 hsa-miR-199a-5p ANKFY1 -0.36 0.04351 0.12 0.13381 miRanda -0.1 0 NA
36 hsa-miR-155-5p ANKH 0.53 0.00249 0.04 0.80588 mirMAP -0.13 0.00035 NA
37 hsa-miR-199a-5p ANKRD22 -0.36 0.04351 -0.93 0.00017 miRanda -0.2 0.00065 NA
38 hsa-miR-199a-5p ANKRD34B -0.36 0.04351 1.37 0.00079 miRanda -0.21 0.03592 NA
39 hsa-miR-199a-5p ANKRD36B -0.36 0.04351 0.48 0.00714 miRanda -0.12 0.00664 NA
40 hsa-miR-155-5p ANO5 0.53 0.00249 -3.22 0 MirTarget -0.25 0.0205 NA
41 hsa-miR-155-5p ANTXR1 0.53 0.00249 0.37 0.02991 miRNAWalker2 validate -0.14 0.00056 NA
42 hsa-miR-155-5p AP1G1 0.53 0.00249 -0.25 0.00213 miRNAWalker2 validate -0.11 0 NA
43 hsa-miR-30a-5p AP4E1 -1.8 0 0.02 0.81319 miRNATAP -0.12 0 NA
44 hsa-miR-30a-5p APBB2 -1.8 0 0.87 0 mirMAP -0.13 0.00026 NA
45 hsa-miR-199a-5p APOL1 -0.36 0.04351 1.76 0 miRanda -0.22 0.00018 NA
46 hsa-miR-199a-5p APOL6 -0.36 0.04351 0.12 0.50637 miRanda -0.22 0 NA
47 hsa-miR-155-5p AR 0.53 0.00249 -3.13 0 mirMAP -0.19 0.04268 NA
48 hsa-miR-145-5p ARAP2 -0.47 0.00069 -0.12 0.4455 MirTarget -0.18 0.00017 NA
49 hsa-miR-145-5p ARF6 -0.47 0.00069 -0.43 0 MirTarget -0.1 0.0004 25253741 lincRNA RoR and miR 145 regulate invasion in triple negative breast cancer via targeting ARF6
50 hsa-miR-199a-5p ARF6 -0.36 0.04351 -0.43 0 MirTarget; PITA; miRanda; miRNATAP -0.1 0 NA
51 hsa-miR-193b-5p ARHGAP26 1.1 0 -0.65 0.00029 mirMAP -0.44 0 NA
52 hsa-miR-155-5p ARHGAP32 0.53 0.00249 -0.97 0 mirMAP -0.18 0 NA
53 hsa-miR-155-5p ARHGAP5 0.53 0.00249 -0.43 0.00026 mirMAP -0.13 0 NA
54 hsa-miR-199a-5p ARID3B -0.36 0.04351 0.32 0.006 miRanda -0.12 1.0E-5 NA
55 hsa-miR-155-5p ARL10 0.53 0.00249 0.03 0.88663 miRNAWalker2 validate -0.12 0.01005 NA
56 hsa-miR-155-5p ARL15 0.53 0.00249 -0.21 0.17368 miRNAWalker2 validate; miRNATAP -0.1 0.00608 NA
57 hsa-miR-155-5p ARL2BP 0.53 0.00249 0.14 0.06649 MirTarget -0.11 0 NA
58 hsa-miR-145-5p ARL5B -0.47 0.00069 -0.22 0.1625 MirTarget -0.13 0.00985 NA
59 hsa-miR-199a-5p ARL6IP1 -0.36 0.04351 0.55 0 miRanda -0.12 0 NA
60 hsa-miR-30a-5p ARRDC4 -1.8 0 0.56 0.0027 mirMAP -0.26 0 NA
61 hsa-miR-30a-5p ASAP1 -1.8 0 0.94 0 miRNATAP -0.2 0 NA
62 hsa-miR-30a-5p ASCC3 -1.8 0 0.14 0.20099 miRNAWalker2 validate; MirTarget -0.11 3.0E-5 NA
63 hsa-miR-155-5p ASNS 0.53 0.00249 0.75 0 miRNAWalker2 validate -0.1 0.00685 NA
64 hsa-miR-155-5p ASPH 0.53 0.00249 0.03 0.80132 miRNAWalker2 validate -0.12 0.00011 NA
65 hsa-miR-30a-5p ATF2 -1.8 0 0.1 0.47373 mirMAP -0.12 0.0008 NA
66 hsa-miR-155-5p ATF7 0.53 0.00249 -0.28 0.00178 mirMAP -0.1 0 NA
67 hsa-miR-30a-5p ATL3 -1.8 0 0.29 0.02783 mirMAP -0.2 0 NA
68 hsa-miR-199a-5p ATP10B -0.36 0.04351 -1.99 0 miRanda -0.26 0.00292 NA
69 hsa-miR-155-5p ATP2B1 0.53 0.00249 0.59 1.0E-5 miRNATAP -0.16 0 NA
70 hsa-miR-30a-5p ATP2B1 -1.8 0 0.59 1.0E-5 MirTarget; mirMAP; miRNATAP -0.14 1.0E-5 NA
71 hsa-miR-30a-5p ATP6V1C1 -1.8 0 0.79 0 miRNAWalker2 validate -0.14 0 NA
72 hsa-miR-155-5p ATRNL1 0.53 0.00249 -1.25 0.00065 MirTarget; mirMAP -0.35 9.0E-5 NA
73 hsa-miR-155-5p ATXN1L 0.53 0.00249 0.02 0.81815 miRNATAP -0.12 1.0E-5 NA
74 hsa-miR-30a-5p AVL9 -1.8 0 0.23 0.01535 MirTarget; mirMAP; miRNATAP -0.19 0 NA
75 hsa-miR-199a-5p B3GNT3 -0.36 0.04351 -0.55 0.04778 miRanda -0.37 0 NA
76 hsa-miR-30a-5p B3GNT5 -1.8 0 0.31 0.05343 MirTarget; miRNATAP -0.33 0 NA
77 hsa-miR-199a-5p BACH1 -0.36 0.04351 0.02 0.88442 miRanda -0.16 0 NA
78 hsa-miR-30a-5p BACH1 -1.8 0 0.02 0.88442 miRNATAP -0.17 0 NA
79 hsa-miR-30a-5p BAG4 -1.8 0 0.1 0.55198 mirMAP -0.13 0.00147 NA
80 hsa-miR-155-5p BAG5 0.53 0.00249 -0.33 0 miRNAWalker2 validate -0.11 0 NA
81 hsa-miR-30a-5p BCL11B -1.8 0 0.6 0.00031 miRNATAP -0.32 0 NA
82 hsa-miR-155-5p BCL6 0.53 0.00249 -0.43 0.00039 miRNAWalker2 validate; miRTarBase -0.15 0 23169640 We show that Bcl6 is indirectly regulated by miR-155 through Mxd1/Mad1 up-regulation; Interestingly we found that miR-155 directly targets HDAC4 a corepressor partner of BCL6; Meta-analysis of the diffuse large B-cell lymphoma patient microarray data showed that miR-155 expression is inversely correlated with Bcl6 and Hdac4; Hence this study provides a better understanding of how miR-155 causes disruption of the BCL6 transcriptional machinery that leads to up-regulation of the survival and proliferation genes in miR-155-induced leukemias
83 hsa-miR-155-5p BCORL1 0.53 0.00249 0.35 0.0045 MirTarget -0.21 0 NA
84 hsa-miR-155-5p BDNF 0.53 0.00249 0.04 0.88345 miRNATAP -0.23 0.00094 NA
85 hsa-miR-193b-5p BEND7 1.1 0 -1.93 0 mirMAP -0.59 0 NA
86 hsa-miR-148a-5p BICD1 -1 0 1.53 0 mirMAP -0.11 0.00714 NA
87 hsa-miR-30a-5p BICD1 -1.8 0 1.53 0 mirMAP -0.25 0 NA
88 hsa-miR-148a-5p BICD2 -1 0 0.46 0.00054 mirMAP -0.12 0.0001 NA
89 hsa-miR-199a-5p BLK -0.36 0.04351 0.52 0.18133 miRanda -0.19 0.04566 NA
90 hsa-miR-30a-5p BNC1 -1.8 0 1.78 0 MirTarget; miRNATAP -0.67 0 NA
91 hsa-miR-155-5p BOC 0.53 0.00249 -2.04 0 MirTarget -0.11 0.03831 NA
92 hsa-miR-199a-5p BRCA1 -0.36 0.04351 1.08 0 miRanda -0.21 0 NA
93 hsa-miR-155-5p BRD1 0.53 0.00249 -0.19 0.01331 MirTarget -0.1 0 NA
94 hsa-miR-155-5p BRWD3 0.53 0.00249 -0.21 0.20442 miRNATAP -0.12 0.00358 NA
95 hsa-miR-30a-5p BRWD3 -1.8 0 -0.21 0.20442 MirTarget; miRNATAP -0.12 0.00336 NA
96 hsa-miR-143-5p BSPRY 0.5 0.00432 -2.1 0 MirTarget -0.32 2.0E-5 NA
97 hsa-miR-199a-5p BSPRY -0.36 0.04351 -2.1 0 miRanda -0.3 3.0E-5 NA
98 hsa-miR-30a-5p BTBD7 -1.8 0 -0 0.98244 miRNATAP -0.14 0 NA
99 hsa-miR-139-5p BUB1 -1.46 0 1.79 0 miRanda -0.29 0 NA
100 hsa-miR-199a-5p BUB1 -0.36 0.04351 1.79 0 miRanda -0.19 0 NA
101 hsa-miR-199b-5p BUB1 -1.08 0 1.79 0 miRanda -0.23 0 NA
102 hsa-miR-495-3p BUB1 -1.48 0 1.79 0 MirTarget -0.2 0 NA
103 hsa-miR-653-5p BUB1 -1.05 0 1.79 0 MirTarget -0.2 0 NA
104 hsa-miR-155-5p C16orf87 0.53 0.00249 0.37 0.00013 mirMAP -0.1 2.0E-5 NA
105 hsa-miR-30a-5p C16orf87 -1.8 0 0.37 0.00013 miRNATAP -0.11 0 NA
106 hsa-miR-30a-5p C6orf132 -1.8 0 -1.12 0 mirMAP -0.11 0.00988 NA
107 hsa-miR-30a-5p C7orf43 -1.8 0 0.38 0 miRNATAP -0.11 0 NA
108 hsa-miR-148a-5p CA12 -1 0 0.07 0.78271 MirTarget -0.23 2.0E-5 NA
109 hsa-miR-199a-5p CALB1 -0.36 0.04351 4.4 0 miRanda -0.35 0.02193 NA
110 hsa-miR-30a-5p CALB2 -1.8 0 -0.4 0.25774 miRNATAP -0.26 0.00238 NA
111 hsa-miR-155-5p CALU 0.53 0.00249 0.94 0 miRNAWalker2 validate -0.18 0 NA
112 hsa-miR-30a-5p CALU -1.8 0 0.94 0 MirTarget -0.1 0.00116 NA
113 hsa-miR-30a-5p CAND1 -1.8 0 0.35 0.00016 mirMAP -0.14 0 NA
114 hsa-miR-30a-5p CAPZA1 -1.8 0 0.23 0.01273 MirTarget; miRNATAP -0.13 0 NA
115 hsa-miR-155-5p CARD10 0.53 0.00249 0.62 0.0007 MirTarget -0.12 0.00644 NA
116 hsa-miR-145-5p CASP10 -0.47 0.00069 0.04 0.78895 mirMAP -0.21 0 NA
117 hsa-miR-199a-5p CASP4 -0.36 0.04351 -0.17 0.26799 miRanda -0.13 0.0003 NA
118 hsa-miR-193b-5p CBFA2T2 1.1 0 0.2 0.05841 mirMAP -0.16 0 NA
119 hsa-miR-193b-5p CBFA2T3 1.1 0 -0.34 0.08121 mirMAP -0.18 0.00029 NA
120 hsa-miR-199a-5p CBL -0.36 0.04351 0.36 0.00252 MirTarget; PITA; miRNATAP -0.12 4.0E-5 NA
121 hsa-miR-30a-5p CBLB -1.8 0 1 0 MirTarget -0.15 0 NA
122 hsa-miR-30a-5p CBX2 -1.8 0 1.48 0 miRNATAP -0.33 0 NA
123 hsa-miR-199a-5p CCDC15 -0.36 0.04351 0.19 0.08531 miRanda -0.16 0 NA
124 hsa-miR-199a-5p CCDC88C -0.36 0.04351 0.11 0.42319 PITA; miRanda; miRNATAP -0.11 0.00094 NA
125 hsa-miR-33a-5p CCL5 1.13 0 1.31 0 MirTarget -0.23 1.0E-5 NA
126 hsa-miR-30a-5p CCNA1 -1.8 0 1.54 0.00197 MirTarget -0.48 9.0E-5 NA
127 hsa-miR-199a-5p CCNA2 -0.36 0.04351 1.57 0 miRanda -0.21 0 NA
128 hsa-miR-155-5p CCND1 0.53 0.00249 -0.01 0.95947 miRNAWalker2 validate -0.21 0.0001 26955820 MicroRNA 155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastric cancer cell growth by targeting cyclin D1
129 hsa-miR-30a-5p CCNE2 -1.8 0 1.24 0 miRNATAP -0.16 5.0E-5 NA
130 hsa-miR-148a-5p CD109 -1 0 1.07 0 mirMAP -0.11 0.00343 NA
131 hsa-miR-155-5p CD109 0.53 0.00249 1.07 0 miRNAWalker2 validate -0.18 0 NA
132 hsa-miR-155-5p CD36 0.53 0.00249 -1.17 4.0E-5 miRNAWalker2 validate -0.33 0 NA
133 hsa-miR-148a-5p CD44 -1 0 0.51 7.0E-5 mirMAP -0.12 8.0E-5 23861222 In MHCC97H and MHCC97L cells over-expression of miR-148a blocked the EMT process attenuated the expression of CD90 and CD44 biomarkers for liver cancer stem cells and inhibited their migratory capacity
134 hsa-miR-30a-5p CD44 -1.8 0 0.51 7.0E-5 miRNAWalker2 validate -0.23 0 NA
135 hsa-miR-145-5p CD47 -0.47 0.00069 0.43 0.00075 miRNATAP -0.15 0.00016 NA
136 hsa-miR-30a-5p CDC20 -1.8 0 1.92 0 miRNAWalker2 validate -0.27 0 NA
137 hsa-miR-155-5p CDC42BPB 0.53 0.00249 0.05 0.6247 miRNAWalker2 validate -0.17 0 NA
138 hsa-miR-199a-5p CDC6 -0.36 0.04351 1.92 0 miRanda -0.17 0 NA
139 hsa-miR-199a-5p CDC7 -0.36 0.04351 1.03 0 MirTarget; miRanda -0.17 0 NA
140 hsa-miR-30a-5p CDCP1 -1.8 0 0.18 0.22385 miRNAWalker2 validate -0.23 0 NA
141 hsa-miR-199a-5p CDH1 -0.36 0.04351 -0.13 0.4686 MirTarget; miRanda -0.18 2.0E-5 25080937 In contrast inhibition of miR-199a-5p impaired the metastatic potential of GC cells in vitro and in vivo and E-cadherin was identified as a direct and functional target of miR-199a-5p in GC cells
142 hsa-miR-155-5p CDH13 0.53 0.00249 0.42 0.06126 miRNAWalker2 validate -0.33 0 NA
143 hsa-miR-30a-5p CDK12 -1.8 0 0.31 0.00076 MirTarget; miRNATAP -0.17 0 NA
144 hsa-miR-148a-5p CDK6 -1 0 0.94 0 mirMAP -0.17 6.0E-5 NA
145 hsa-miR-30a-5p CDK6 -1.8 0 0.94 0 mirMAP -0.24 0 NA
146 hsa-miR-155-5p CDS1 0.53 0.00249 -0.63 0 miRNATAP -0.13 5.0E-5 NA
147 hsa-miR-193b-5p CEACAM5 1.1 0 -3.14 0 MirTarget -0.93 0 NA
148 hsa-miR-30a-5p CELSR3 -1.8 0 2.18 0 MirTarget; miRNATAP -0.28 1.0E-5 NA
149 hsa-miR-199a-5p CENPA -0.36 0.04351 2.21 0 miRanda -0.15 0.00021 NA
150 hsa-miR-139-5p CENPF -1.46 0 1.74 0 miRanda -0.31 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 INTRACELLULAR SIGNAL TRANSDUCTION 143 1572 1.892e-13 8.804e-10
2 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 120 1275 2.331e-12 2.711e-09
3 REGULATION OF CELL PROLIFERATION 135 1496 1.805e-12 2.711e-09
4 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 154 1784 1.352e-12 2.711e-09
5 NEUROGENESIS 128 1402 3.322e-12 3.091e-09
6 TISSUE DEVELOPMENT 135 1518 5.169e-12 4.009e-09
7 POSITIVE REGULATION OF GENE EXPRESSION 147 1733 1.795e-11 1.089e-08
8 CELL PROLIFERATION 75 672 2.018e-11 1.089e-08
9 PHOSPHORYLATION 114 1228 2.106e-11 1.089e-08
10 LOCOMOTION 106 1114 2.701e-11 1.257e-08
11 POSITIVE REGULATION OF CELL PROLIFERATION 84 814 6.985e-11 2.955e-08
12 PROTEIN PHOSPHORYLATION 92 944 1.784e-10 6.917e-08
13 REGULATION OF CELLULAR COMPONENT MOVEMENT 79 771 3.724e-10 1.238e-07
14 CELL DEVELOPMENT 123 1426 3.673e-10 1.238e-07
15 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 157 1977 4.794e-10 1.487e-07
16 REGULATION OF CELL DIFFERENTIATION 126 1492 8.269e-10 2.405e-07
17 EPITHELIUM DEVELOPMENT 90 945 9.234e-10 2.527e-07
18 CELL CYCLE PROCESS 99 1081 1.044e-09 2.698e-07
19 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 147 1848 1.713e-09 4.194e-07
20 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 102 1142 2.212e-09 5.147e-07
21 REGULATION OF CELL DEATH 123 1472 2.568e-09 5.69e-07
22 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 134 1656 3.512e-09 7.428e-07
23 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 92 1004 4.15e-09 8.396e-07
24 CELL CYCLE 112 1316 5.27e-09 1.022e-06
25 REGULATION OF EPITHELIAL CELL PROLIFERATION 39 285 6.314e-09 1.175e-06
26 MITOTIC CELL CYCLE 75 766 7.782e-09 1.393e-06
27 REGULATION OF PHOSPHORUS METABOLIC PROCESS 130 1618 9.599e-09 1.654e-06
28 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 91 1008 1.045e-08 1.737e-06
29 CYTOSKELETON ORGANIZATION 79 838 1.635e-08 2.624e-06
30 NEGATIVE REGULATION OF CELL DEATH 81 872 2.053e-08 3.185e-06
31 ACTIN FILAMENT BASED PROCESS 51 450 2.184e-08 3.218e-06
32 PROTEIN LOCALIZATION 140 1805 2.213e-08 3.218e-06
33 CELL MOTILITY 78 835 2.996e-08 4.1e-06
34 LOCALIZATION OF CELL 78 835 2.996e-08 4.1e-06
35 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 139 1805 3.886e-08 5.167e-06
36 HEAD DEVELOPMENT 69 709 4.013e-08 5.187e-06
37 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 71 740 4.481e-08 5.635e-06
38 EMBRYO DEVELOPMENT 81 894 6.062e-08 7.423e-06
39 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 85 957 6.808e-08 7.919e-06
40 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 130 1672 6.643e-08 7.919e-06
41 REGULATION OF PROTEIN MODIFICATION PROCESS 132 1710 7.874e-08 8.723e-06
42 EPITHELIAL CELL DIFFERENTIATION 53 495 7.712e-08 8.723e-06
43 REGULATION OF HYDROLASE ACTIVITY 108 1327 1.046e-07 1.132e-05
44 REGULATION OF CELL ADHESION 62 629 1.269e-07 1.342e-05
45 NEGATIVE REGULATION OF CELL COMMUNICATION 99 1192 1.443e-07 1.492e-05
46 TISSUE MORPHOGENESIS 55 533 1.501e-07 1.519e-05
47 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 109 1360 1.969e-07 1.949e-05
48 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 111 1395 2.168e-07 2.101e-05
49 CELL JUNCTION ORGANIZATION 27 185 3.649e-07 3.372e-05
50 POSITIVE REGULATION OF MOLECULAR FUNCTION 134 1791 3.696e-07 3.372e-05
51 CENTRAL NERVOUS SYSTEM DEVELOPMENT 77 872 3.665e-07 3.372e-05
52 RESPONSE TO ENDOGENOUS STIMULUS 113 1450 4.767e-07 4.266e-05
53 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 117 1517 4.967e-07 4.361e-05
54 CELL DIVISION 48 460 6.747e-07 5.606e-05
55 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 64 689 6.598e-07 5.606e-05
56 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 40 352 6.738e-07 5.606e-05
57 NEURON DIFFERENTIATION 76 874 7.93e-07 6.474e-05
58 CELL CYCLE CHECKPOINT 27 194 9.518e-07 7.636e-05
59 POSITIVE REGULATION OF RESPONSE TO STIMULUS 140 1929 1.095e-06 8.493e-05
60 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 28 207 1.079e-06 8.493e-05
61 NEGATIVE REGULATION OF GENE EXPRESSION 114 1493 1.157e-06 8.585e-05
62 MORPHOGENESIS OF AN EPITHELIUM 43 400 1.17e-06 8.585e-05
63 REGULATION OF CELL SUBSTRATE ADHESION 25 173 1.181e-06 8.585e-05
64 REGULATION OF CELL DEVELOPMENT 73 836 1.13e-06 8.585e-05
65 CELLULAR MACROMOLECULE LOCALIZATION 98 1234 1.291e-06 9.239e-05
66 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 113 1492 1.914e-06 0.0001349
67 GASTRULATION 23 155 1.968e-06 0.0001367
68 FOREBRAIN DEVELOPMENT 39 357 2.466e-06 0.0001663
69 POSITIVE REGULATION OF CELL DIFFERENTIATION 71 823 2.45e-06 0.0001663
70 CELL PROJECTION ORGANIZATION 76 902 2.596e-06 0.0001726
71 POSITIVE REGULATION OF OSSIFICATION 16 84 2.668e-06 0.0001749
72 NEURON PROJECTION GUIDANCE 27 205 2.807e-06 0.0001814
73 REGULATION OF VIRAL GENOME REPLICATION 15 75 2.882e-06 0.0001837
74 NEGATIVE REGULATION OF VIRAL GENOME REPLICATION 12 49 3.044e-06 0.0001914
75 IMMUNE SYSTEM PROCESS 141 1984 3.143e-06 0.000195
76 RESPONSE TO GROWTH FACTOR 47 475 3.844e-06 0.0002353
77 POSITIVE REGULATION OF LOCOMOTION 43 420 4.175e-06 0.0002523
78 POSITIVE REGULATION OF CELL CYCLE PROCESS 30 247 4.345e-06 0.0002592
79 REGULATION OF KINASE ACTIVITY 67 776 4.604e-06 0.0002678
80 CELL JUNCTION ASSEMBLY 20 129 4.574e-06 0.0002678
81 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 17 98 5.004e-06 0.0002806
82 TUBE DEVELOPMENT 52 552 4.978e-06 0.0002806
83 REGULATION OF CELLULAR PROTEIN LOCALIZATION 52 552 4.978e-06 0.0002806
84 BIOLOGICAL ADHESION 83 1032 5.447e-06 0.0003017
85 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 22 153 5.527e-06 0.0003025
86 CELLULAR RESPONSE TO EXTERNAL STIMULUS 31 264 6.101e-06 0.0003301
87 FORMATION OF PRIMARY GERM LAYER 18 110 6.257e-06 0.0003347
88 EXTRACELLULAR STRUCTURE ORGANIZATION 34 304 6.462e-06 0.0003417
89 POSITIVE REGULATION OF CELL COMMUNICATION 113 1532 6.553e-06 0.0003426
90 REGULATION OF CELL PROJECTION ORGANIZATION 52 558 6.767e-06 0.0003499
91 MORPHOGENESIS OF A BRANCHING STRUCTURE 23 167 7.123e-06 0.0003642
92 TELENCEPHALON DEVELOPMENT 28 228 7.267e-06 0.0003676
93 ESTABLISHMENT OF PROTEIN LOCALIZATION 106 1423 8.504e-06 0.0004255
94 REGULATION OF PROTEIN LOCALIZATION 77 950 9.147e-06 0.0004528
95 NEURON DEVELOPMENT 60 687 1.028e-05 0.0005034
96 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 64 750 1.094e-05 0.0005301
97 POSITIVE REGULATION OF CATALYTIC ACTIVITY 111 1518 1.171e-05 0.0005504
98 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 81 1021 1.171e-05 0.0005504
99 UROGENITAL SYSTEM DEVELOPMENT 33 299 1.162e-05 0.0005504
100 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 48 513 1.368e-05 0.0006366
101 EPITHELIAL CELL DEVELOPMENT 24 186 1.401e-05 0.0006453
102 CARDIOVASCULAR SYSTEM DEVELOPMENT 66 788 1.45e-05 0.0006552
103 CIRCULATORY SYSTEM DEVELOPMENT 66 788 1.45e-05 0.0006552
104 NEURON PROJECTION DEVELOPMENT 50 545 1.547e-05 0.000692
105 POSITIVE REGULATION OF CELL DEVELOPMENT 45 472 1.586e-05 0.0007027
106 MESODERM DEVELOPMENT 18 118 1.701e-05 0.0007468
107 ORGAN MORPHOGENESIS 69 841 1.82e-05 0.0007841
108 RESPONSE TO OXYGEN CONTAINING COMPOUND 102 1381 1.811e-05 0.0007841
109 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 87 1135 2.03e-05 0.0008664
110 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 21 154 2.05e-05 0.0008673
111 CELL CYCLE PHASE TRANSITION 29 255 2.214e-05 0.00092
112 ESTABLISHMENT OF CELL POLARITY 15 88 2.213e-05 0.00092
113 MESODERMAL CELL DIFFERENTIATION 8 26 2.273e-05 0.0009359
114 REGULATION OF NEURON DIFFERENTIATION 50 554 2.387e-05 0.0009743
115 NEURON MIGRATION 17 110 2.434e-05 0.0009847
116 REGULATION OF NEURON PROJECTION DEVELOPMENT 40 408 2.465e-05 0.0009886
117 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 61 724 2.569e-05 0.001022
118 REGULATION OF CELLULAR LOCALIZATION 95 1277 2.709e-05 0.001063
119 CELLULAR RESPONSE TO STRESS 112 1565 2.718e-05 0.001063
120 REGULATION OF CELL CYCLE 75 949 2.827e-05 0.001087
121 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 12 60 2.809e-05 0.001087
122 INTERACTION WITH HOST 19 134 2.889e-05 0.001102
123 POSITIVE REGULATION OF CELL DEATH 53 605 3.093e-05 0.00117
124 PEPTIDYL AMINO ACID MODIFICATION 68 841 3.317e-05 0.001245
125 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 80 1036 3.428e-05 0.001266
126 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 80 1036 3.428e-05 0.001266
127 RESPONSE TO MECHANICAL STIMULUS 25 210 3.741e-05 0.001371
128 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 65 799 4.116e-05 0.001485
129 POSITIVE REGULATION OF CELL CYCLE 34 332 4.112e-05 0.001485
130 ANION TRANSPORT 46 507 4.407e-05 0.001577
131 REGULATION OF CELLULAR RESPONSE TO STRESS 58 691 4.501e-05 0.001599
132 EMBRYONIC MORPHOGENESIS 48 539 4.834e-05 0.00169
133 MITOTIC CELL CYCLE CHECKPOINT 19 139 4.84e-05 0.00169
134 REGULATION OF APOPTOTIC SIGNALING PATHWAY 36 363 4.868e-05 0.00169
135 POSITIVE REGULATION OF HYDROLASE ACTIVITY 71 905 5.827e-05 0.002005
136 GLAND DEVELOPMENT 38 395 5.867e-05 0.002005
137 ESTABLISHMENT OR MAINTENANCE OF CELL POLARITY 19 141 5.902e-05 0.002005
138 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 11 55 6.028e-05 0.002032
139 VASCULATURE DEVELOPMENT 43 469 6.093e-05 0.00204
140 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 36 368 6.462e-05 0.002148
141 MESODERM MORPHOGENESIS 12 66 7.543e-05 0.002489
142 REGULATION OF TRANSFERASE ACTIVITY 73 946 7.746e-05 0.002538
143 CIRCADIAN REGULATION OF GENE EXPRESSION 11 57 8.499e-05 0.002766
144 RESPONSE TO ORGANIC CYCLIC COMPOUND 71 917 8.758e-05 0.00283
145 RESPONSE TO EXTERNAL STIMULUS 124 1821 9.104e-05 0.002921
146 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 48 554 9.464e-05 0.002991
147 DNA INTEGRITY CHECKPOINT 19 146 9.513e-05 0.002991
148 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 38 404 9.445e-05 0.002991
149 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 85 1152 9.653e-05 0.003014
150 CELL CYCLE G1 S PHASE TRANSITION 16 111 9.891e-05 0.003048
151 G1 S TRANSITION OF MITOTIC CELL CYCLE 16 111 9.891e-05 0.003048
152 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 40 437 0.0001127 0.00345
153 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 68 876 0.0001143 0.003476
154 REPRODUCTIVE SYSTEM DEVELOPMENT 38 408 0.0001159 0.003481
155 REGULATION OF CELL MATRIX ADHESION 14 90 0.0001157 0.003481
156 RESPONSE TO HORMONE 69 893 0.0001169 0.003487
157 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 23 199 0.0001186 0.003516
158 CELLULAR RESPONSE TO MECHANICAL STIMULUS 13 80 0.0001278 0.003763
159 REGULATION OF COENZYME METABOLIC PROCESS 10 50 0.0001297 0.003773
160 REGULATION OF COFACTOR METABOLIC PROCESS 10 50 0.0001297 0.003773
161 STEM CELL PROLIFERATION 11 60 0.0001381 0.003965
162 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 11 60 0.0001381 0.003965
163 REGULATION OF TRANSPORT 122 1804 0.000139 0.003969
164 LENS FIBER CELL DIFFERENTIATION 7 25 0.0001457 0.004134
165 SISTER CHROMATID SEGREGATION 21 176 0.0001475 0.004159
166 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 25 229 0.0001533 0.004298
167 MESENCHYME DEVELOPMENT 22 190 0.000161 0.004461
168 POSITIVE REGULATION OF STEM CELL PROLIFERATION 11 61 0.0001611 0.004461
169 CELLULAR RESPONSE TO HORMONE STIMULUS 47 552 0.0001677 0.004616
170 REGULATION OF CELL DIVISION 28 272 0.0001744 0.004773
171 PALLIUM DEVELOPMENT 19 153 0.000178 0.004842
172 NEURON PROJECTION MORPHOGENESIS 37 402 0.0001799 0.004867
173 NEUTRAL AMINO ACID TRANSPORT 8 34 0.0001864 0.005013
174 MORPHOGENESIS OF AN EPITHELIAL SHEET 9 43 0.0001947 0.005208
175 RESPONSE TO CYTOKINE 57 714 0.0001986 0.005279
176 REGULATION OF ORGANELLE ORGANIZATION 85 1178 0.000203 0.005367
177 POSITIVE REGULATION OF CELL ADHESION 35 376 0.0002146 0.005642
178 HEART DEVELOPMENT 41 466 0.0002174 0.005682
179 RAS PROTEIN SIGNAL TRANSDUCTION 18 143 0.00022 0.005718
180 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 17 131 0.0002255 0.00583
181 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 43 498 0.000232 0.005963
182 CELL CELL JUNCTION ASSEMBLY 12 74 0.0002347 0.006001
183 CARDIAC SEPTUM DEVELOPMENT 13 85 0.000239 0.006078
184 POSITIVE REGULATION OF NEURON DIFFERENTIATION 30 306 0.0002457 0.006193
185 BLOOD VESSEL MORPHOGENESIS 34 364 0.0002462 0.006193
186 CELLULAR COMPONENT MORPHOGENESIS 68 900 0.0002492 0.006235
187 NEGATIVE REGULATION OF CELL ADHESION 24 223 0.0002554 0.006339
188 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 5 13 0.0002575 0.006339
189 REGULATION OF GTPASE ACTIVITY 54 673 0.0002562 0.006339
190 GROWTH 37 410 0.0002654 0.006499
191 REGULATION OF CYTOSKELETON ORGANIZATION 43 502 0.0002754 0.006708
192 REGULATION OF NEURON DEATH 26 252 0.0002826 0.006848
193 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 18 146 0.0002853 0.006879
194 MICROVILLUS ORGANIZATION 6 20 0.0002904 0.006966
195 RESPONSE TO ABIOTIC STIMULUS 75 1024 0.00031 0.007397
196 REGULATION OF LIPID METABOLIC PROCESS 28 282 0.0003172 0.007493
197 REGULATION OF CELL MORPHOGENESIS 46 552 0.0003169 0.007493
198 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 14 99 0.0003237 0.007569
199 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 14 99 0.0003237 0.007569
200 SISTER CHROMATID COHESION 15 111 0.0003327 0.007741
201 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 22 200 0.0003348 0.007741
202 REGULATION OF BINDING 28 283 0.0003361 0.007741
203 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 14 100 0.0003598 0.008247
204 ORGANIC ANION TRANSPORT 35 387 0.0003693 0.008422
205 NEGATIVE REGULATION OF VIRAL PROCESS 13 89 0.0003799 0.00854
206 EPITHELIAL CELL PROLIFERATION 13 89 0.0003799 0.00854
207 POST EMBRYONIC DEVELOPMENT 13 89 0.0003799 0.00854
208 CIRCADIAN RHYTHM 17 137 0.0003858 0.008589
209 CDP DIACYLGLYCEROL METABOLIC PROCESS 5 14 0.0003844 0.008589
210 REGULATION OF CELL CYCLE PROCESS 46 558 0.0004015 0.008897
211 CHROMOSOME SEGREGATION 27 272 0.0004042 0.008914
212 ENDOMEMBRANE SYSTEM ORGANIZATION 40 465 0.0004075 0.008944
213 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 33 360 0.0004227 0.009227
214 STEM CELL DIFFERENTIATION 21 190 0.0004244 0.009227
NumGOOverlapSizeP ValueAdj. P Value
1 RIBONUCLEOTIDE BINDING 172 1860 7.815e-17 7.26e-14
2 ENZYME BINDING 157 1737 1.685e-14 7.826e-12
3 MACROMOLECULAR COMPLEX BINDING 134 1399 2.622e-14 8.12e-12
4 ADENYL NUCLEOTIDE BINDING 140 1514 1.007e-13 2.338e-11
5 KINASE ACTIVITY 84 842 3.761e-10 6.146e-08
6 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 45 328 3.969e-10 6.146e-08
7 CYTOSKELETAL PROTEIN BINDING 82 819 5.193e-10 6.26e-08
8 PROTEIN COMPLEX BINDING 90 935 5.39e-10 6.26e-08
9 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 93 992 1.069e-09 1.103e-07
10 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 67 629 1.769e-09 1.644e-07
11 REGULATORY REGION NUCLEIC ACID BINDING 80 818 2.532e-09 2.138e-07
12 DOUBLE STRANDED DNA BINDING 75 764 6.955e-09 5.385e-07
13 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 33 226 1.868e-08 1.335e-06
14 PROTEIN KINASE ACTIVITY 64 640 4.645e-08 3.082e-06
15 CORE PROMOTER PROXIMAL REGION DNA BINDING 43 371 1.489e-07 9.221e-06
16 KINASE BINDING 60 606 1.741e-07 1.011e-05
17 HYDROLASE ACTIVITY ACTING ON ACID ANHYDRIDES 74 820 2.704e-07 1.478e-05
18 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 98 1199 3.53e-07 1.822e-05
19 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 37 315 7.873e-07 3.85e-05
20 ACTIN BINDING 42 393 1.811e-06 8.41e-05
21 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 55 588 3.295e-06 0.0001458
22 SEQUENCE SPECIFIC DNA BINDING 84 1037 3.622e-06 0.000153
23 PROTEIN DOMAIN SPECIFIC BINDING 57 624 4.526e-06 0.0001828
24 PROTEIN SERINE THREONINE KINASE ACTIVITY 44 445 7.93e-06 0.0003069
25 IDENTICAL PROTEIN BINDING 93 1209 9.025e-06 0.0003354
26 GROWTH FACTOR BINDING 18 123 3.024e-05 0.001081
27 DOUBLE STRANDED RNA BINDING 12 64 5.506e-05 0.001894
28 COLLAGEN BINDING 12 65 6.455e-05 0.002142
29 MOTOR ACTIVITY 18 131 7.076e-05 0.002267
30 TUBULIN BINDING 29 273 7.735e-05 0.002395
31 GUANYL NUCLEOTIDE BINDING 37 390 9.743e-05 0.00292
32 NEUTRAL AMINO ACID TRANSMEMBRANE TRANSPORTER ACTIVITY 8 32 0.0001178 0.003319
33 CELL ADHESION MOLECULE BINDING 22 186 0.0001179 0.003319
34 PROTEIN KINASE C BINDING 10 50 0.0001297 0.003444
35 GTPASE BINDING 30 295 0.0001293 0.003444
36 MOLECULAR FUNCTION REGULATOR 96 1353 0.000144 0.003717
37 CORE PROMOTER BINDING 19 152 0.0001632 0.004097
38 INTEGRIN BINDING 15 105 0.0001789 0.004374
39 GTPASE ACTIVITY 26 246 0.0001929 0.004481
40 TRANSCRIPTION FACTOR BINDING 45 524 0.0001892 0.004481
41 CHROMATIN BINDING 39 435 0.0002096 0.004749
42 RAB GTPASE BINDING 16 120 0.0002497 0.005522
43 DNA BINDING BENDING 6 20 0.0002904 0.006275
44 MICROFILAMENT MOTOR ACTIVITY 6 21 0.0003899 0.008231
45 GLYCOPROTEIN BINDING 14 101 0.0003992 0.008242
NumGOOverlapSizeP ValueAdj. P Value
1 ANCHORING JUNCTION 63 489 1.994e-12 7.911e-10
2 CELL LEADING EDGE 51 350 2.709e-12 7.911e-10
3 CELL SUBSTRATE JUNCTION 54 398 1.063e-11 2.07e-09
4 CELL JUNCTION 109 1151 1.834e-11 2.678e-09
5 CELL CELL JUNCTION 50 383 2.498e-10 2.918e-08
6 CYTOSKELETON 152 1967 6.277e-09 6.11e-07
7 NEURON PROJECTION 84 942 6.871e-08 5.733e-06
8 MEMBRANE REGION 96 1134 9.304e-08 6.792e-06
9 ACTIN CYTOSKELETON 48 444 2.383e-07 1.392e-05
10 GOLGI APPARATUS 114 1445 2.265e-07 1.392e-05
11 PLASMA MEMBRANE REGION 81 929 3.036e-07 1.612e-05
12 APICAL JUNCTION COMPLEX 21 128 1.036e-06 5.044e-05
13 CELL PROJECTION 131 1786 1.474e-06 6.624e-05
14 RUFFLE 23 156 2.203e-06 8.725e-05
15 ENDOPLASMIC RETICULUM 121 1631 2.241e-06 8.725e-05
16 CYTOSKELETAL PART 109 1436 2.675e-06 9.765e-05
17 CHROMOSOME 73 880 7.105e-06 0.0002441
18 LEADING EDGE MEMBRANE 20 134 8.253e-06 0.0002677
19 PROTEIN COMPLEX INVOLVED IN CELL ADHESION 9 30 8.764e-06 0.0002694
20 LAMELLIPODIUM 22 172 3.611e-05 0.001054
21 PRONUCLEUS 6 15 4.631e-05 0.001288
22 NEURON PART 93 1265 5.142e-05 0.001318
23 DENDRITE 42 451 5.19e-05 0.001318
24 CELL CELL CONTACT ZONE 12 64 5.506e-05 0.00134
25 RECYCLING ENDOSOME 18 131 7.076e-05 0.001653
26 AXON 39 418 9.129e-05 0.002051
27 SOMATODENDRITIC COMPARTMENT 54 650 0.0001069 0.002311
28 GOLGI APPARATUS PART 69 893 0.0001169 0.002439
29 CELL PROJECTION PART 72 946 0.0001322 0.002662
30 ACTOMYOSIN 11 62 0.0001873 0.003528
31 INTRACELLULAR VESICLE 90 1259 0.0001815 0.003528
32 CONDENSED CHROMOSOME 22 195 0.000234 0.004271
33 CELL CELL ADHERENS JUNCTION 10 54 0.0002531 0.00448
34 CELL SURFACE 59 757 0.000289 0.004963
35 ENDOPLASMIC RETICULUM PART 83 1163 0.0003412 0.005694
36 RECEPTOR COMPLEX 31 327 0.0003518 0.005706
37 SITE OF POLARIZED GROWTH 18 149 0.000367 0.005793
38 MICROTUBULE CYTOSKELETON 77 1068 0.0004137 0.006195
39 SUPRAMOLECULAR FIBER 53 670 0.0004092 0.006195
40 TRANS GOLGI NETWORK 21 193 0.0005232 0.007639
41 CHROMATIN 38 441 0.0005444 0.007754
42 FILOPODIUM 13 94 0.00065 0.009038
43 BASOLATERAL PLASMA MEMBRANE 22 211 0.0006984 0.009486

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Cell_cycle_hsa04110 27 124 4.481e-11 2.33e-09
2 PI3K_Akt_signaling_pathway_hsa04151 42 352 9.257e-08 2.407e-06
3 MAPK_signaling_pathway_hsa04010 35 295 1.231e-06 2.134e-05
4 ErbB_signaling_pathway_hsa04012 16 85 3.139e-06 4.081e-05
5 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 19 139 4.84e-05 0.0005033
6 FoxO_signaling_pathway_hsa04068 18 132 7.826e-05 0.0005684
7 AMPK_signaling_pathway_hsa04152 17 121 8.411e-05 0.0005684
8 Regulation_of_actin_cytoskeleton_hsa04810 24 208 8.744e-05 0.0005684
9 Ras_signaling_pathway_hsa04014 25 232 0.0001881 0.001087
10 Cellular_senescence_hsa04218 19 160 0.0003183 0.001655
11 Hippo_signaling_pathway_hsa04390 18 154 0.0005483 0.002592
12 HIF_1_signaling_pathway_hsa04066 13 100 0.001172 0.005079
13 p53_signaling_pathway_hsa04115 10 68 0.001659 0.006634
14 Focal_adhesion_hsa04510 20 199 0.001866 0.006931
15 Endocytosis_hsa04144 23 244 0.002077 0.007202
16 TGF_beta_signaling_pathway_hsa04350 11 84 0.002577 0.008374
17 Rap1_signaling_pathway_hsa04015 20 206 0.002801 0.008567
18 Tight_junction_hsa04530 17 170 0.004153 0.012
19 ECM_receptor_interaction_hsa04512 10 82 0.006611 0.01809
20 Apelin_signaling_pathway_hsa04371 14 137 0.00731 0.01901
21 Adherens_junction_hsa04520 9 72 0.008314 0.02059
22 Hippo_signaling_pathway_multiple_species_hsa04392 5 29 0.0124 0.02818
23 Phospholipase_D_signaling_pathway_hsa04072 14 146 0.01246 0.02818
24 mTOR_signaling_pathway_hsa04150 14 151 0.01635 0.03542
25 Apoptosis_hsa04210 13 138 0.01794 0.03704
26 Oocyte_meiosis_hsa04114 12 124 0.01852 0.03704
27 Hedgehog_signaling_pathway_hsa04340 6 47 0.02627 0.05059
28 Gap_junction_hsa04540 9 88 0.0281 0.05219
29 TNF_signaling_pathway_hsa04668 10 108 0.03889 0.06772
30 Mitophagy_animal_hsa04137 7 65 0.03907 0.06772
31 Cytokine_cytokine_receptor_interaction_hsa04060 19 270 0.07228 0.1212
32 Autophagy_animal_hsa04140 10 128 0.09737 0.1582
33 Phagosome_hsa04145 11 152 0.1264 0.1992
34 Ferroptosis_hsa04216 4 40 0.1305 0.1996
35 Jak_STAT_signaling_pathway_hsa04630 11 162 0.1712 0.2544
36 Wnt_signaling_pathway_hsa04310 10 146 0.179 0.2544
37 Necroptosis_hsa04217 11 164 0.181 0.2544
38 Phosphatidylinositol_signaling_system_hsa04070 7 99 0.2111 0.2888
39 VEGF_signaling_pathway_hsa04370 4 59 0.327 0.436
40 Sphingolipid_signaling_pathway_hsa04071 7 118 0.3567 0.4637
41 cAMP_signaling_pathway_hsa04024 11 198 0.3773 0.4785
42 cGMP_PKG_signaling_pathway_hsa04022 9 163 0.4044 0.5006
43 NF_kappa_B_signaling_pathway_hsa04064 5 95 0.4995 0.604
44 Cell_adhesion_molecules_.CAMs._hsa04514 7 145 0.5694 0.6729
45 Lysosome_hsa04142 5 123 0.7253 0.8381
46 Calcium_signaling_pathway_hsa04020 6 182 0.8859 0.9506
47 Neuroactive_ligand_receptor_interaction_hsa04080 6 278 0.994 1

Quest ID: 586f1ea62108c7a80d4711520be2212f