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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-21-5p AKT2 1.75 0 -0.01 0.9227 miRNAWalker2 validate -0.15 0.00352 NA
2 hsa-miR-29b-3p AKT2 -0.23 0.36746 -0.01 0.9227 MirTarget -0.14 0.00022 26512921; 26564501; 24076586 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3;The expression of miR-29b was significantly upregualted by cisplatin treatmentwhile its target gene AKT2 was downregulated;Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis
3 hsa-miR-106b-5p AKT3 1.71 0 -0.75 0.06936 miRNATAP -0.37 7.0E-5 NA
4 hsa-miR-107 AKT3 0.9 5.0E-5 -0.75 0.06936 PITA; miRanda -0.6 0 NA
5 hsa-miR-15b-5p AKT3 1.62 0 -0.75 0.06936 miRNATAP -0.36 0.00041 NA
6 hsa-miR-16-5p AKT3 1.01 1.0E-5 -0.75 0.06936 miRNAWalker2 validate; miRTarBase; miRNATAP -0.47 0.00031 NA
7 hsa-miR-17-3p AKT3 1.31 0 -0.75 0.06936 miRNATAP -0.52 0 NA
8 hsa-miR-17-5p AKT3 1.66 0 -0.75 0.06936 TargetScan; miRNATAP -0.28 0.0027 NA
9 hsa-miR-29a-3p AKT3 -0.11 0.61501 -0.75 0.06936 miRNATAP -0.41 0.00212 NA
10 hsa-miR-29b-3p AKT3 -0.23 0.36746 -0.75 0.06936 miRNATAP -0.34 0.00361 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
11 hsa-miR-32-3p AKT3 0.58 0.11837 -0.75 0.06936 mirMAP -0.32 0.00023 NA
12 hsa-miR-320b AKT3 1.11 0.0005 -0.75 0.06936 PITA; miRanda; miRNATAP -0.26 0.0039 NA
13 hsa-miR-335-3p AKT3 2.52 0 -0.75 0.06936 mirMAP -0.22 0.00074 NA
14 hsa-miR-33a-3p AKT3 0.35 0.32171 -0.75 0.06936 mirMAP -0.38 2.0E-5 NA
15 hsa-miR-362-3p AKT3 -0.03 0.91378 -0.75 0.06936 miRanda -0.38 4.0E-5 NA
16 hsa-miR-362-5p AKT3 -0.35 0.35491 -0.75 0.06936 PITA; TargetScan; miRNATAP -0.23 0.00253 NA
17 hsa-miR-501-3p AKT3 0.73 0.02704 -0.75 0.06936 miRNATAP -0.39 1.0E-5 NA
18 hsa-miR-502-3p AKT3 -0.16 0.55747 -0.75 0.06936 miRNATAP -0.5 0 NA
19 hsa-miR-505-3p AKT3 0.83 0.00112 -0.75 0.06936 mirMAP -0.35 0.00235 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR
20 hsa-miR-548v AKT3 -0.16 0.70867 -0.75 0.06936 miRNATAP -0.27 0.00031 NA
21 hsa-miR-577 AKT3 0.91 0.22561 -0.75 0.06936 mirMAP -0.23 0 NA
22 hsa-miR-616-5p AKT3 0.83 0.03478 -0.75 0.06936 mirMAP -0.27 0.00041 NA
23 hsa-miR-103a-3p CAB39 0.84 0 -0.33 0.05024 MirTarget; miRNATAP -0.24 0.00078 NA
24 hsa-miR-107 CAB39 0.9 5.0E-5 -0.33 0.05024 MirTarget; miRanda; miRNATAP -0.14 0.00671 NA
25 hsa-miR-151a-3p CAB39 1 1.0E-5 -0.33 0.05024 MirTarget -0.17 0.00082 NA
26 hsa-miR-15b-5p CAB39 1.62 0 -0.33 0.05024 miRNATAP -0.16 5.0E-5 NA
27 hsa-miR-23b-3p CAB39 -0.29 0.18665 -0.33 0.05024 MirTarget; miRNATAP -0.15 0.00624 NA
28 hsa-miR-27b-3p CAB39 0.08 0.72527 -0.33 0.05024 MirTarget; miRNATAP -0.13 0.00845 NA
29 hsa-miR-374b-3p CAB39 1 0.00127 -0.33 0.05024 MirTarget -0.13 0.00076 NA
30 hsa-miR-155-5p CAB39L 1.29 9.0E-5 -2.75 0 miRNAWalker2 validate -0.21 0.00812 NA
31 hsa-miR-214-5p CAB39L 1.03 0.00141 -2.75 0 MirTarget -0.34 3.0E-5 NA
32 hsa-miR-3662 CAB39L 1.83 0.0054 -2.75 0 MirTarget; miRNATAP -0.16 0.00158 NA
33 hsa-miR-542-3p CAB39L 0.76 0.00211 -2.75 0 miRanda -0.39 0.00033 NA
34 hsa-miR-590-3p CAB39L 1.12 0.00016 -2.75 0 miRanda -0.35 0.0001 NA
35 hsa-miR-590-5p CAB39L 1.04 0.00027 -2.75 0 miRanda -0.42 0 NA
36 hsa-miR-125a-5p EIF4E2 -0.88 0.00021 -0.03 0.82669 miRanda -0.15 2.0E-5 NA
37 hsa-miR-125a-5p EIF4EBP1 -0.88 0.00021 1.1 0.00073 miRNAWalker2 validate; MirTarget; miRanda; miRNATAP -0.41 2.0E-5 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression
38 hsa-miR-106b-5p HIF1A 1.71 0 0.84 0.00084 MirTarget -0.17 0.00333 NA
39 hsa-miR-107 HIF1A 0.9 5.0E-5 0.84 0.00084 miRNAWalker2 validate; miRTarBase; miRanda -0.36 1.0E-5 NA
40 hsa-miR-139-5p HIF1A -1.83 0 0.84 0.00084 miRanda -0.16 0.00469 NA
41 hsa-miR-151a-3p HIF1A 1 1.0E-5 0.84 0.00084 MirTarget -0.23 0.00333 NA
42 hsa-miR-320c HIF1A 0.46 0.24061 0.84 0.00084 miRanda -0.15 0.00656 NA
43 hsa-miR-330-3p HIF1A 0.8 0.00747 0.84 0.00084 MirTarget; PITA -0.18 0.00313 NA
44 hsa-miR-338-3p HIF1A -0.96 0.01915 0.84 0.00084 MirTarget; PITA; miRanda -0.18 3.0E-5 NA
45 hsa-miR-338-5p HIF1A -1.2 0.01003 0.84 0.00084 MirTarget; PITA; miRNATAP -0.14 0.0002 NA
46 hsa-miR-361-5p HIF1A 0.41 0.01813 0.84 0.00084 miRanda -0.31 0.00432 NA
47 hsa-miR-660-5p HIF1A -0.02 0.93887 0.84 0.00084 MirTarget -0.28 2.0E-5 NA
48 hsa-let-7a-3p IGF1 0.5 0.04111 -2.08 0.00135 mirMAP -0.55 0.00422 NA
49 hsa-let-7b-3p IGF1 0.22 0.29604 -2.08 0.00135 mirMAP -0.64 0.00549 NA
50 hsa-let-7f-1-3p IGF1 1.29 0 -2.08 0.00135 mirMAP -0.85 0 NA
51 hsa-miR-103a-2-5p IGF1 0.81 0.01999 -2.08 0.00135 mirMAP -0.55 3.0E-5 NA
52 hsa-miR-130b-3p IGF1 1.33 5.0E-5 -2.08 0.00135 MirTarget -0.9 0 NA
53 hsa-miR-15b-3p IGF1 1.76 0 -2.08 0.00135 mirMAP -0.97 0 NA
54 hsa-miR-16-1-3p IGF1 1.43 0 -2.08 0.00135 mirMAP -0.89 0 NA
55 hsa-miR-181b-5p IGF1 1.64 0 -2.08 0.00135 mirMAP -0.48 0.00175 NA
56 hsa-miR-186-5p IGF1 0.15 0.43471 -2.08 0.00135 mirMAP -0.85 0.00061 NA
57 hsa-miR-19a-3p IGF1 1.27 0.00011 -2.08 0.00135 MirTarget -0.77 0 NA
58 hsa-miR-19b-1-5p IGF1 1.39 0 -2.08 0.00135 mirMAP -0.93 0 NA
59 hsa-miR-19b-3p IGF1 0.76 0.00653 -2.08 0.00135 MirTarget -0.82 0 NA
60 hsa-miR-20a-3p IGF1 1.14 0.00045 -2.08 0.00135 mirMAP -0.99 0 NA
61 hsa-miR-27a-3p IGF1 1.3 0 -2.08 0.00135 miRNAWalker2 validate; miRTarBase -0.62 0.00158 NA
62 hsa-miR-301a-3p IGF1 1.45 1.0E-5 -2.08 0.00135 MirTarget -0.44 0.00199 NA
63 hsa-miR-301b-3p IGF1 1.1 0.07156 -2.08 0.00135 MirTarget -0.49 0 NA
64 hsa-miR-3065-5p IGF1 -0.24 0.63312 -2.08 0.00135 mirMAP -0.28 0.00304 NA
65 hsa-miR-32-3p IGF1 0.58 0.11837 -2.08 0.00135 mirMAP -0.53 0.00017 NA
66 hsa-miR-320a IGF1 0.59 0.0119 -2.08 0.00135 miRNATAP -0.57 0.00471 NA
67 hsa-miR-320b IGF1 1.11 0.0005 -2.08 0.00135 miRNATAP -0.64 1.0E-5 NA
68 hsa-miR-320c IGF1 0.46 0.24061 -2.08 0.00135 miRNATAP -0.42 0.00294 NA
69 hsa-miR-33a-3p IGF1 0.35 0.32171 -2.08 0.00135 MirTarget -0.68 0 NA
70 hsa-miR-3662 IGF1 1.83 0.0054 -2.08 0.00135 MirTarget -0.45 0 NA
71 hsa-miR-421 IGF1 1.81 0 -2.08 0.00135 PITA -0.45 0.00067 NA
72 hsa-miR-454-3p IGF1 0.63 0.01349 -2.08 0.00135 MirTarget -0.55 0.00337 NA
73 hsa-miR-486-5p IGF1 -0.63 0.15527 -2.08 0.00135 PITA; miRNATAP -0.38 0.00034 NA
74 hsa-miR-576-5p IGF1 0.63 0.04171 -2.08 0.00135 PITA; mirMAP; miRNATAP -0.76 0 NA
75 hsa-miR-577 IGF1 0.91 0.22561 -2.08 0.00135 PITA -0.36 0 NA
76 hsa-miR-590-3p IGF1 1.12 0.00016 -2.08 0.00135 MirTarget; miRanda; mirMAP; miRNATAP -0.61 8.0E-5 NA
77 hsa-miR-592 IGF1 0.78 0.2045 -2.08 0.00135 mirMAP -0.41 0 NA
78 hsa-miR-629-5p IGF1 1.06 0.00054 -2.08 0.00135 mirMAP -0.88 0 NA
79 hsa-miR-940 IGF1 1.64 0.00069 -2.08 0.00135 MirTarget; PITA; miRNATAP -0.45 5.0E-5 NA
80 hsa-miR-126-5p MAPK1 0.42 0.07532 -0.5 0.00057 mirMAP -0.12 0.00476 NA
81 hsa-miR-140-3p MAPK1 -0.3 0.12754 -0.5 0.00057 PITA; miRNATAP -0.15 0.00713 NA
82 hsa-miR-140-5p MAPK1 0.21 0.303 -0.5 0.00057 miRanda -0.17 0.00108 NA
83 hsa-miR-142-5p MAPK1 1.56 1.0E-5 -0.5 0.00057 mirMAP -0.12 2.0E-5 NA
84 hsa-miR-16-5p MAPK1 1.01 1.0E-5 -0.5 0.00057 mirMAP -0.13 0.00527 NA
85 hsa-miR-17-3p MAPK1 1.31 0 -0.5 0.00057 mirMAP -0.11 0.00661 NA
86 hsa-miR-32-5p MAPK1 0.42 0.10646 -0.5 0.00057 mirMAP -0.13 0.00101 NA
87 hsa-miR-320a MAPK1 0.59 0.0119 -0.5 0.00057 miRNAWalker2 validate; PITA; miRanda; miRNATAP -0.12 0.00441 NA
88 hsa-miR-320b MAPK1 1.11 0.0005 -0.5 0.00057 PITA; miRanda; miRNATAP -0.12 0.00017 NA
89 hsa-miR-3614-3p MAPK1 0.82 0.01436 -0.5 0.00057 mirMAP -0.14 0 NA
90 hsa-miR-22-5p PDPK1 0.8 0.0008 -0.59 4.0E-5 miRNATAP -0.13 0.00306 NA
91 hsa-miR-24-3p PDPK1 1.09 0 -0.59 4.0E-5 miRNAWalker2 validate -0.14 0.00295 NA
92 hsa-miR-27a-3p PDPK1 1.3 0 -0.59 4.0E-5 miRNATAP -0.13 0.00311 NA
93 hsa-miR-424-5p PDPK1 1.09 0.00042 -0.59 4.0E-5 mirMAP -0.13 0.00011 NA
94 hsa-miR-542-3p PDPK1 0.76 0.00211 -0.59 4.0E-5 mirMAP -0.16 0.00014 NA
95 hsa-miR-326 PGF -0.43 0.26299 2.29 0 mirMAP -0.25 0.00397 NA
96 hsa-miR-335-5p PGF 1.6 6.0E-5 2.29 0 miRNATAP -0.28 0.0004 NA
97 hsa-miR-429 PGF 1.4 0.009 2.29 0 miRNATAP -0.17 0.00414 NA
98 hsa-miR-126-5p PIK3CA 0.42 0.07532 0.18 0.37992 mirMAP -0.23 0.00023 NA
99 hsa-miR-146a-5p PIK3CA 1.82 2.0E-5 0.18 0.37992 mirMAP -0.13 8.0E-5 NA
100 hsa-miR-148a-5p PIK3CA -0.69 0.0793 0.18 0.37992 mirMAP -0.16 1.0E-5 NA
101 hsa-miR-148b-3p PIK3CA 0.3 0.17466 0.18 0.37992 miRNAWalker2 validate -0.27 6.0E-5 NA
102 hsa-miR-186-5p PIK3CA 0.15 0.43471 0.18 0.37992 mirMAP -0.28 0.00025 NA
103 hsa-miR-29b-1-5p PIK3CA 0.61 0.11636 0.18 0.37992 mirMAP -0.11 0.00515 NA
104 hsa-miR-320b PIK3CA 1.11 0.0005 0.18 0.37992 miRanda -0.13 0.00356 NA
105 hsa-miR-335-5p PIK3CA 1.6 6.0E-5 0.18 0.37992 miRNAWalker2 validate -0.14 7.0E-5 NA
106 hsa-miR-338-5p PIK3CA -1.2 0.01003 0.18 0.37992 mirMAP -0.13 3.0E-5 NA
107 hsa-miR-501-5p PIK3CA 0.27 0.45478 0.18 0.37992 mirMAP -0.18 0 NA
108 hsa-miR-7-1-3p PIK3CA 0.71 0.04123 0.18 0.37992 mirMAP -0.18 1.0E-5 NA
109 hsa-miR-130a-3p PIK3CB 0.15 0.63374 0.25 0.18038 miRNATAP -0.14 0.001 NA
110 hsa-miR-1468-5p PIK3CD -1.88 3.0E-5 0.39 0.25308 MirTarget -0.22 3.0E-5 NA
111 hsa-miR-30b-3p PIK3CD -0.27 0.40085 0.39 0.25308 MirTarget -0.43 0 NA
112 hsa-miR-30b-5p PIK3CD -0.43 0.05936 0.39 0.25308 MirTarget -0.48 1.0E-5 NA
113 hsa-miR-30d-5p PIK3CD -0.55 0.01401 0.39 0.25308 MirTarget; miRNATAP -0.67 0 NA
114 hsa-miR-616-5p PIK3CD 0.83 0.03478 0.39 0.25308 MirTarget -0.17 0.00628 NA
115 hsa-miR-7-5p PIK3CD 1.64 0.01244 0.39 0.25308 miRTarBase; MirTarget; miRNATAP -0.21 0 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway
116 hsa-miR-103a-3p PIK3R1 0.84 0 -1.09 2.0E-5 MirTarget; miRNATAP -0.32 0.00394 NA
117 hsa-miR-106b-5p PIK3R1 1.71 0 -1.09 2.0E-5 MirTarget; miRNATAP -0.25 2.0E-5 NA
118 hsa-miR-107 PIK3R1 0.9 5.0E-5 -1.09 2.0E-5 MirTarget; PITA; miRanda; miRNATAP -0.24 0.00469 NA
119 hsa-miR-128-3p PIK3R1 0.98 6.0E-5 -1.09 2.0E-5 MirTarget -0.25 0.00086 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients
120 hsa-miR-144-3p PIK3R1 -0.13 0.79825 -1.09 2.0E-5 mirMAP -0.14 0.00013 NA
121 hsa-miR-15b-5p PIK3R1 1.62 0 -1.09 2.0E-5 MirTarget -0.32 0 NA
122 hsa-miR-16-2-3p PIK3R1 1.8 0 -1.09 2.0E-5 MirTarget -0.27 0 NA
123 hsa-miR-16-5p PIK3R1 1.01 1.0E-5 -1.09 2.0E-5 MirTarget -0.41 0 NA
124 hsa-miR-17-5p PIK3R1 1.66 0 -1.09 2.0E-5 MirTarget; TargetScan; miRNATAP -0.19 0.00107 NA
125 hsa-miR-182-5p PIK3R1 0.89 0.03106 -1.09 2.0E-5 miRNATAP -0.16 0.0004 NA
126 hsa-miR-185-5p PIK3R1 1.14 0 -1.09 2.0E-5 miRNATAP -0.42 0 NA
127 hsa-miR-188-5p PIK3R1 1.35 0.00038 -1.09 2.0E-5 MirTarget -0.16 0.00078 NA
128 hsa-miR-200b-3p PIK3R1 0.97 0.0595 -1.09 2.0E-5 mirMAP -0.1 0.0041 NA
129 hsa-miR-200c-3p PIK3R1 1.28 0.0037 -1.09 2.0E-5 mirMAP -0.14 0.00064 NA
130 hsa-miR-20a-5p PIK3R1 1.45 0 -1.09 2.0E-5 MirTarget; miRNATAP -0.18 0.00561 NA
131 hsa-miR-21-5p PIK3R1 1.75 0 -1.09 2.0E-5 miRNAWalker2 validate; MirTarget; miRNATAP -0.31 0.00155 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer
132 hsa-miR-212-3p PIK3R1 0.96 0.00133 -1.09 2.0E-5 MirTarget -0.23 0.00022 NA
133 hsa-miR-22-5p PIK3R1 0.8 0.0008 -1.09 2.0E-5 mirMAP -0.27 0.0005 NA
134 hsa-miR-221-3p PIK3R1 1.33 0 -1.09 2.0E-5 MirTarget -0.31 1.0E-5 NA
135 hsa-miR-222-3p PIK3R1 1.39 0 -1.09 2.0E-5 MirTarget -0.28 1.0E-5 NA
136 hsa-miR-3065-5p PIK3R1 -0.24 0.63312 -1.09 2.0E-5 MirTarget; mirMAP; miRNATAP -0.12 0.00106 NA
137 hsa-miR-32-3p PIK3R1 0.58 0.11837 -1.09 2.0E-5 mirMAP -0.17 0.00228 NA
138 hsa-miR-320b PIK3R1 1.11 0.0005 -1.09 2.0E-5 miRNATAP -0.16 0.00545 NA
139 hsa-miR-324-3p PIK3R1 1.05 0.00039 -1.09 2.0E-5 MirTarget; PITA; miRNATAP -0.18 0.00348 NA
140 hsa-miR-330-3p PIK3R1 0.8 0.00747 -1.09 2.0E-5 MirTarget; PITA; miRNATAP -0.26 2.0E-5 NA
141 hsa-miR-335-3p PIK3R1 2.52 0 -1.09 2.0E-5 mirMAP -0.15 0.0005 NA
142 hsa-miR-424-5p PIK3R1 1.09 0.00042 -1.09 2.0E-5 MirTarget -0.29 0 NA
143 hsa-miR-429 PIK3R1 1.4 0.009 -1.09 2.0E-5 mirMAP; miRNATAP -0.13 0.00023 NA
144 hsa-miR-455-3p PIK3R1 2.3 0 -1.09 2.0E-5 MirTarget; PITA; miRNATAP -0.18 1.0E-5 NA
145 hsa-miR-542-3p PIK3R1 0.76 0.00211 -1.09 2.0E-5 MirTarget; PITA; miRanda -0.24 0.00173 NA
146 hsa-miR-584-5p PIK3R1 1.68 0.00017 -1.09 2.0E-5 mirMAP -0.13 0.00171 NA
147 hsa-miR-590-3p PIK3R1 1.12 0.00016 -1.09 2.0E-5 miRanda; mirMAP -0.27 2.0E-5 NA
148 hsa-miR-590-5p PIK3R1 1.04 0.00027 -1.09 2.0E-5 MirTarget; PITA; miRanda; miRNATAP -0.3 0 NA
149 hsa-miR-629-3p PIK3R1 1.4 0.0001 -1.09 2.0E-5 MirTarget -0.17 0.00118 NA
150 hsa-miR-96-5p PIK3R1 1.14 0.00943 -1.09 2.0E-5 TargetScan; miRNATAP -0.19 1.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHORYLATION 25 1228 4.062e-23 1.89e-19
2 PROTEIN PHOSPHORYLATION 22 944 4.355e-21 1.013e-17
3 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 26 1977 1.852e-19 2.873e-16
4 INTRACELLULAR SIGNAL TRANSDUCTION 24 1572 4.685e-19 5.45e-16
5 INOSITOL LIPID MEDIATED SIGNALING 10 124 9.343e-15 8.695e-12
6 POSITIVE REGULATION OF RESPONSE TO STIMULUS 22 1929 1.724e-14 1.337e-11
7 RESPONSE TO INSULIN 11 205 3.372e-14 2.241e-11
8 PEPTIDYL SERINE MODIFICATION 10 148 5.673e-14 3.299e-11
9 REGULATION OF PHOSPHORUS METABOLIC PROCESS 20 1618 1.282e-13 6.628e-11
10 CELLULAR RESPONSE TO HORMONE STIMULUS 14 552 1.722e-13 8.014e-11
11 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 13 498 1.085e-12 4.588e-10
12 RESPONSE TO PEPTIDE 12 404 2.153e-12 8.349e-10
13 CELLULAR RESPONSE TO INSULIN STIMULUS 9 146 2.757e-12 9.869e-10
14 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 6 25 3.161e-12 1.051e-09
15 RESPONSE TO HORMONE 15 893 6.998e-12 2.171e-09
16 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 7 59 8.483e-12 2.467e-09
17 REGULATION OF GLUCOSE IMPORT 7 60 9.592e-12 2.625e-09
18 REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 11 354 1.306e-11 3.376e-09
19 REGULATION OF TOR SIGNALING 7 68 2.384e-11 5.839e-09
20 CELLULAR RESPONSE TO PEPTIDE 10 274 2.684e-11 6.244e-09
21 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 18 1656 3.536e-11 7.835e-09
22 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 7 74 4.393e-11 9.292e-09
23 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 15 1036 5.741e-11 1.113e-08
24 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 15 1036 5.741e-11 1.113e-08
25 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 13 689 6.315e-11 1.175e-08
26 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 14 867 7.401e-11 1.279e-08
27 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 5 17 7.425e-11 1.279e-08
28 T CELL RECEPTOR SIGNALING PATHWAY 8 146 1.324e-10 2.201e-08
29 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 6 49 2.422e-10 3.887e-08
30 REGULATION OF KINASE ACTIVITY 13 776 2.738e-10 4.247e-08
31 RESPONSE TO OXYGEN CONTAINING COMPOUND 16 1381 2.835e-10 4.256e-08
32 REGULATION OF AUTOPHAGY 9 249 3.312e-10 4.816e-08
33 REGULATION OF GLUCOSE TRANSPORT 7 100 3.785e-10 5.337e-08
34 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 13 799 3.919e-10 5.363e-08
35 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 14 1008 5.363e-10 7.13e-08
36 CELLULAR RESPONSE TO NITROGEN COMPOUND 11 505 5.758e-10 7.443e-08
37 RESPONSE TO NITROGEN COMPOUND 13 859 9.492e-10 1.194e-07
38 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 8 195 1.329e-09 1.627e-07
39 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 7 120 1.372e-09 1.637e-07
40 NEGATIVE REGULATION OF TOR SIGNALING 5 30 1.682e-09 1.957e-07
41 CELLULAR RESPONSE TO STRESS 16 1565 1.777e-09 2.017e-07
42 REGULATION OF TRANSFERASE ACTIVITY 13 946 3.059e-09 3.389e-07
43 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 10 448 3.201e-09 3.456e-07
44 PROTEIN KINASE B SIGNALING 5 34 3.268e-09 3.456e-07
45 POSITIVE REGULATION OF AUTOPHAGY 6 75 3.377e-09 3.492e-07
46 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 7 138 3.656e-09 3.698e-07
47 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 12 3.85e-09 3.812e-07
48 INSULIN RECEPTOR SIGNALING PATHWAY 6 80 5.008e-09 4.855e-07
49 RESPONSE TO ENDOGENOUS STIMULUS 15 1450 6.075e-09 5.769e-07
50 CELL CYCLE ARREST 7 154 7.853e-09 7.24e-07
51 RESPONSE TO ABIOTIC STIMULUS 13 1024 7.936e-09 7.24e-07
52 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 15 1492 8.958e-09 8.016e-07
53 REGULATION OF GENERATION OF PRECURSOR METABOLITES AND ENERGY 6 89 9.577e-09 8.408e-07
54 POSITIVE REGULATION OF GLUCOSE TRANSPORT 5 42 9.892e-09 8.524e-07
55 POSITIVE REGULATION OF CELL COMMUNICATION 15 1532 1.282e-08 1.085e-06
56 NEGATIVE REGULATION OF CELL DEATH 12 872 1.445e-08 1.2e-06
57 GLUCOSE HOMEOSTASIS 7 170 1.559e-08 1.25e-06
58 CARBOHYDRATE HOMEOSTASIS 7 170 1.559e-08 1.25e-06
59 AUTOPHAGY 9 394 1.831e-08 1.403e-06
60 POSITIVE REGULATION OF NUCLEOTIDE CATABOLIC PROCESS 4 17 1.84e-08 1.403e-06
61 LIPID PHOSPHORYLATION 6 99 1.824e-08 1.403e-06
62 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 16 1848 1.955e-08 1.467e-06
63 ACTIVATION OF PROTEIN KINASE ACTIVITY 8 279 2.203e-08 1.627e-06
64 REGULATION OF LIPID METABOLIC PROCESS 8 282 2.394e-08 1.74e-06
65 REGULATION OF CATABOLIC PROCESS 11 731 2.7e-08 1.908e-06
66 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 13 1135 2.706e-08 1.908e-06
67 CELL ACTIVATION 10 568 3.054e-08 2.121e-06
68 POSITIVE REGULATION OF LOCOMOTION 9 420 3.174e-08 2.172e-06
69 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 7 193 3.739e-08 2.422e-06
70 REGULATION OF IMMUNE SYSTEM PROCESS 14 1403 3.747e-08 2.422e-06
71 REGULATION OF CELL CYCLE 12 949 3.687e-08 2.422e-06
72 ACTIVATION OF IMMUNE RESPONSE 9 427 3.658e-08 2.422e-06
73 REGULATION OF PROTEIN MODIFICATION PROCESS 15 1710 5.613e-08 3.578e-06
74 LIPID MODIFICATION 7 210 6.671e-08 4.059e-06
75 POSITIVE REGULATION OF GENE EXPRESSION 15 1733 6.706e-08 4.059e-06
76 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 4 23 6.795e-08 4.059e-06
77 GLYCEROLIPID BIOSYNTHETIC PROCESS 7 211 6.891e-08 4.059e-06
78 REGULATION OF CELL DEATH 14 1472 6.85e-08 4.059e-06
79 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 8 323 6.834e-08 4.059e-06
80 POSITIVE REGULATION OF NUCLEOSIDE METABOLIC PROCESS 4 24 8.144e-08 4.678e-06
81 POSITIVE REGULATION OF ATP METABOLIC PROCESS 4 24 8.144e-08 4.678e-06
82 POSITIVE REGULATION OF CATALYTIC ACTIVITY 14 1518 1.006e-07 5.71e-06
83 POSITIVE REGULATION OF KINASE ACTIVITY 9 482 1.03e-07 5.751e-06
84 POSITIVE REGULATION OF MOLECULAR FUNCTION 15 1791 1.038e-07 5.751e-06
85 RESPONSE TO ACTIVITY 5 69 1.263e-07 6.916e-06
86 RESPONSE TO EXTERNAL STIMULUS 15 1821 1.293e-07 6.997e-06
87 PHOSPHOLIPID BIOSYNTHETIC PROCESS 7 235 1.437e-07 7.685e-06
88 PLATELET ACTIVATION 6 142 1.578e-07 8.252e-06
89 FC EPSILON RECEPTOR SIGNALING PATHWAY 6 142 1.578e-07 8.252e-06
90 POSITIVE REGULATION OF CARBOHYDRATE METABOLIC PROCESS 5 75 1.926e-07 9.957e-06
91 POSITIVE REGULATION OF CELL ADHESION 8 376 2.188e-07 1.119e-05
92 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 6 154 2.551e-07 1.29e-05
93 LIPID BIOSYNTHETIC PROCESS 9 539 2.652e-07 1.327e-05
94 POSITIVE REGULATION OF CATABOLIC PROCESS 8 395 3.183e-07 1.576e-05
95 RESPONSE TO WOUNDING 9 563 3.825e-07 1.854e-05
96 POSITIVE REGULATION OF IMMUNE RESPONSE 9 563 3.825e-07 1.854e-05
97 REGULATION OF NUCLEOTIDE CATABOLIC PROCESS 4 36 4.448e-07 2.133e-05
98 REGULATION OF CELL MATRIX ADHESION 5 90 4.813e-07 2.285e-05
99 REGULATION OF CELLULAR COMPONENT MOVEMENT 10 771 5.229e-07 2.458e-05
100 REGULATION OF EPITHELIAL CELL PROLIFERATION 7 285 5.297e-07 2.465e-05
101 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 7 289 5.817e-07 2.68e-05
102 FC GAMMA RECEPTOR SIGNALING PATHWAY 5 95 6.305e-07 2.829e-05
103 CARDIOVASCULAR SYSTEM DEVELOPMENT 10 788 6.383e-07 2.829e-05
104 NEGATIVE REGULATION OF CELL CYCLE 8 433 6.377e-07 2.829e-05
105 CIRCULATORY SYSTEM DEVELOPMENT 10 788 6.383e-07 2.829e-05
106 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 4 40 6.866e-07 3.014e-05
107 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 7 297 6.987e-07 3.038e-05
108 RESPONSE TO EXTRACELLULAR STIMULUS 8 441 7.321e-07 3.154e-05
109 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 9 616 8.114e-07 3.464e-05
110 REGULATION OF CELLULAR CARBOHYDRATE CATABOLIC PROCESS 4 42 8.389e-07 3.499e-05
111 REGULATION OF TRANSPORT 14 1804 8.423e-07 3.499e-05
112 REGULATION OF CARBOHYDRATE CATABOLIC PROCESS 4 42 8.389e-07 3.499e-05
113 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 12 1275 9.038e-07 3.722e-05
114 RESPONSE TO OXYGEN LEVELS 7 311 9.511e-07 3.882e-05
115 REGULATION OF CELL ADHESION 9 629 9.652e-07 3.905e-05
116 REGULATION OF GROWTH 9 633 1.017e-06 4.081e-05
117 CELL MOTILITY 10 835 1.082e-06 4.266e-05
118 LOCALIZATION OF CELL 10 835 1.082e-06 4.266e-05
119 PEPTIDYL AMINO ACID MODIFICATION 10 841 1.154e-06 4.506e-05
120 VASCULATURE DEVELOPMENT 8 469 1.162e-06 4.506e-05
121 WOUND HEALING 8 470 1.181e-06 4.541e-05
122 CELL CYCLE 12 1316 1.264e-06 4.822e-05
123 FC RECEPTOR SIGNALING PATHWAY 6 206 1.405e-06 5.314e-05
124 REGULATION OF LIPID KINASE ACTIVITY 4 48 1.447e-06 5.432e-05
125 REGULATION OF NUCLEOSIDE METABOLIC PROCESS 4 49 1.574e-06 5.813e-05
126 REGULATION OF ATP METABOLIC PROCESS 4 49 1.574e-06 5.813e-05
127 REGULATION OF COENZYME METABOLIC PROCESS 4 50 1.709e-06 6.212e-05
128 REGULATION OF COFACTOR METABOLIC PROCESS 4 50 1.709e-06 6.212e-05
129 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 5 118 1.85e-06 6.621e-05
130 LOCOMOTION 11 1114 1.844e-06 6.621e-05
131 REGULATION OF BODY FLUID LEVELS 8 506 2.049e-06 7.276e-05
132 GLYCEROLIPID METABOLIC PROCESS 7 356 2.337e-06 8.216e-05
133 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 11 1142 2.349e-06 8.216e-05
134 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 7 360 2.516e-06 8.737e-05
135 PHOSPHOLIPID METABOLIC PROCESS 7 364 2.707e-06 9.261e-05
136 TOR SIGNALING 3 16 2.707e-06 9.261e-05
137 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 4 61 3.82e-06 0.0001297
138 RESPONSE TO OSMOTIC STRESS 4 63 4.349e-06 0.0001467
139 CELLULAR RESPONSE TO OXYGEN LEVELS 5 143 4.758e-06 0.0001593
140 REGULATION OF CELL PROLIFERATION 12 1496 4.838e-06 0.0001608
141 LEUKOCYTE MIGRATION 6 259 5.272e-06 0.000174
142 CELL DEATH 10 1001 5.506e-06 0.0001792
143 RESPONSE TO MUSCLE ACTIVITY 3 20 5.484e-06 0.0001792
144 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 4 67 5.569e-06 0.0001799
145 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 4 68 5.91e-06 0.0001896
146 POSITIVE REGULATION OF NEUROBLAST PROLIFERATION 3 21 6.39e-06 0.0002036
147 POSITIVE REGULATION OF CELL PROLIFERATION 9 814 7.975e-06 0.0002524
148 CELLULAR GLUCOSE HOMEOSTASIS 4 75 8.744e-06 0.0002731
149 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 5 162 8.742e-06 0.0002731
150 REGULATION OF POSITIVE CHEMOTAXIS 3 24 9.689e-06 0.0003006
151 LYMPHOCYTE COSTIMULATION 4 78 1.022e-05 0.000315
152 ANGIOGENESIS 6 293 1.066e-05 0.0003264
153 ERBB SIGNALING PATHWAY 4 79 1.076e-05 0.0003271
154 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 7 450 1.086e-05 0.0003281
155 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 6 296 1.13e-05 0.0003392
156 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 5 172 1.169e-05 0.0003487
157 REGULATION OF CELL SUBSTRATE ADHESION 5 173 1.202e-05 0.0003563
158 REGULATION OF IMMUNE RESPONSE 9 858 1.218e-05 0.0003586
159 REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 3 27 1.395e-05 0.0004083
160 CHEMICAL HOMEOSTASIS 9 874 1.412e-05 0.0004105
161 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 7 470 1.439e-05 0.000416
162 POSITIVE REGULATION OF CELL ACTIVATION 6 311 1.496e-05 0.0004269
163 HEMOSTASIS 6 311 1.496e-05 0.0004269
164 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 12 1672 1.513e-05 0.0004293
165 REGULATION OF NEUROBLAST PROLIFERATION 3 28 1.561e-05 0.0004401
166 IMMUNE SYSTEM PROCESS 13 1984 1.57e-05 0.0004402
167 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 4 88 1.651e-05 0.0004599
168 IMMUNE EFFECTOR PROCESS 7 486 1.786e-05 0.0004947
169 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 10 1152 1.888e-05 0.0005175
170 PHAGOCYTOSIS 5 190 1.891e-05 0.0005175
171 CELL DEVELOPMENT 11 1426 1.965e-05 0.0005347
172 CELLULAR LIPID METABOLIC PROCESS 9 913 1.998e-05 0.0005375
173 PROTEIN AUTOPHOSPHORYLATION 5 192 1.988e-05 0.0005375
174 NEGATIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 3 31 2.134e-05 0.0005706
175 POSITIVE REGULATION OF TRANSPORT 9 936 2.434e-05 0.0006471
176 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 4 98 2.526e-05 0.0006669
177 NEGATIVE REGULATION OF CELL COMMUNICATION 10 1192 2.537e-05 0.0006669
178 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 7 514 2.56e-05 0.0006691
179 REGULATION OF PROTEIN LOCALIZATION 9 950 2.737e-05 0.0007114
180 POSITIVE REGULATION OF MAP KINASE ACTIVITY 5 207 2.853e-05 0.0007376
181 REGULATION OF CELL DIFFERENTIATION 11 1492 2.999e-05 0.0007709
182 REGULATION OF NUCLEOTIDE METABOLIC PROCESS 5 211 3.127e-05 0.0007995
183 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 12 1805 3.268e-05 0.0008273
184 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 5 213 3.271e-05 0.0008273
185 BLOOD VESSEL MORPHOGENESIS 6 364 3.624e-05 0.0009114
186 REGULATION OF CELLULAR PROTEIN LOCALIZATION 7 552 4.034e-05 0.001009
187 REGULATION OF CELLULAR LOCALIZATION 10 1277 4.578e-05 0.001139
188 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 5 229 4.621e-05 0.001142
189 POSITIVE REGULATION OF CELL MATRIX ADHESION 3 40 4.64e-05 0.001142
190 MAMMARY GLAND DEVELOPMENT 4 117 5.063e-05 0.00124
191 REGULATION OF CELL GROWTH 6 391 5.397e-05 0.001308
192 POSITIVE REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 3 42 5.378e-05 0.001308
193 POSITIVE REGULATION OF GROWTH 5 238 5.55e-05 0.001338
194 IMMUNE SYSTEM DEVELOPMENT 7 582 5.641e-05 0.001353
195 GLAND DEVELOPMENT 6 395 5.711e-05 0.001363
196 RESPONSE TO ELECTRICAL STIMULUS 3 43 5.775e-05 0.001371
197 POSITIVE REGULATION OF CELL CELL ADHESION 5 243 6.125e-05 0.001447
198 SINGLE ORGANISM BIOSYNTHETIC PROCESS 10 1340 6.886e-05 0.001618
199 POSITIVE REGULATION OF CELL DIFFERENTIATION 8 823 6.954e-05 0.001626
200 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 4 129 7.407e-05 0.001723
201 CELL CYCLE PROCESS 9 1081 7.505e-05 0.001737
202 NEGATIVE REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 4 131 7.864e-05 0.001794
203 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 10 1360 7.801e-05 0.001794
204 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 9 1087 7.832e-05 0.001794
205 POSITIVE REGULATION OF RESPONSE TO EXTRACELLULAR STIMULUS 3 48 8.045e-05 0.001817
206 POSITIVE REGULATION OF RESPONSE TO NUTRIENT LEVELS 3 48 8.045e-05 0.001817
207 POSITIVE REGULATION OF CELL DIVISION 4 132 8.099e-05 0.001821
208 POSITIVE REGULATION OF PURINE NUCLEOTIDE METABOLIC PROCESS 4 133 8.34e-05 0.001848
209 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 4 133 8.34e-05 0.001848
210 POSITIVE REGULATION OF NUCLEOTIDE METABOLIC PROCESS 4 133 8.34e-05 0.001848
211 CELLULAR RESPONSE TO ABIOTIC STIMULUS 5 263 8.899e-05 0.001962
212 CELLULAR RESPONSE TO EXTERNAL STIMULUS 5 264 9.059e-05 0.001988
213 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 10 1395 9.655e-05 0.002109
214 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 6 437 9.971e-05 0.002168
215 REGULATION OF CELL DIVISION 5 272 0.0001042 0.002256
216 NEURON PROJECTION EXTENSION 3 53 0.0001083 0.002312
217 MAMMARY GLAND EPITHELIUM DEVELOPMENT 3 53 0.0001083 0.002312
218 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 8 876 0.0001076 0.002312
219 NEGATIVE REGULATION OF REPRODUCTIVE PROCESS 3 54 0.0001145 0.002434
220 EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 3 55 0.000121 0.002557
221 MACROAUTOPHAGY 5 281 0.0001214 0.002557
222 REGULATION OF MAPK CASCADE 7 660 0.000124 0.002587
223 EMBRYO DEVELOPMENT 8 894 0.0001239 0.002587
224 POSITIVE REGULATION OF CELL GROWTH 4 148 0.0001261 0.00262
225 LIPID METABOLIC PROCESS 9 1158 0.0001272 0.002631
226 REGULATION OF VESICLE MEDIATED TRANSPORT 6 462 0.0001352 0.002783
227 REGULATION OF DEVELOPMENTAL GROWTH 5 289 0.0001385 0.002839
228 LEUKOCYTE DIFFERENTIATION 5 292 0.0001453 0.002953
229 REGULATION OF ORGANELLE ORGANIZATION 9 1178 0.000145 0.002953
230 REGULATION OF RESPONSE TO STRESS 10 1468 0.0001476 0.002973
231 RESPONSE TO STARVATION 4 154 0.000147 0.002973
232 POSITIVE REGULATION OF MAPK CASCADE 6 470 0.0001484 0.002977
233 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 3 60 0.0001569 0.003133
234 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 8 926 0.000158 0.003141
235 REGULATION OF CELLULAR RESPONSE TO STRESS 7 691 0.0001647 0.00325
236 POSITIVE REGULATION OF STEM CELL PROLIFERATION 3 61 0.0001648 0.00325
237 REGULATION OF CELL ACTIVATION 6 484 0.0001741 0.003418
238 EPITHELIUM DEVELOPMENT 8 945 0.0001816 0.003551
239 REGULATION OF HOMOTYPIC CELL CELL ADHESION 5 307 0.0001835 0.003573
240 FATTY ACID HOMEOSTASIS 2 12 0.0001942 0.003755
241 TISSUE DEVELOPMENT 10 1518 0.0001945 0.003755
242 REGULATION OF EPITHELIAL CELL MIGRATION 4 166 0.0001961 0.00377
243 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 8 957 0.000198 0.003792
244 RESPONSE TO CARBOHYDRATE 4 168 0.0002053 0.003914
245 VESICLE MEDIATED TRANSPORT 9 1239 0.0002123 0.004032
246 REGULATION OF RESPONSE TO EXTRACELLULAR STIMULUS 4 171 0.0002196 0.004121
247 REGULATION OF RESPONSE TO NUTRIENT LEVELS 4 171 0.0002196 0.004121
248 REGULATION OF MAP KINASE ACTIVITY 5 319 0.0002193 0.004121
249 REGULATION OF CELL SIZE 4 172 0.0002246 0.004197
250 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 5 321 0.0002257 0.004201
251 INDUCTION OF POSITIVE CHEMOTAXIS 2 13 0.0002293 0.00425
252 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 6 513 0.0002385 0.004403
253 CELLULAR RESPONSE TO ELECTRICAL STIMULUS 2 14 0.0002672 0.004895
254 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 2 14 0.0002672 0.004895
255 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 8 1004 0.0002746 0.005011
256 REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 3 73 0.0002808 0.005103
257 REGULATION OF CELLULAR COMPONENT SIZE 5 337 0.0002826 0.005116
258 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 3 74 0.0002923 0.005271
259 REGULATION OF CELLULAR COMPONENT BIOGENESIS 7 767 0.000312 0.005606
260 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 4 188 0.0003152 0.005641
261 DEVELOPMENTAL CELL GROWTH 3 77 0.0003286 0.005859
262 DEVELOPMENTAL MATURATION 4 193 0.0003483 0.006185
263 MAMMARY GLAND EPITHELIAL CELL DIFFERENTIATION 2 16 0.0003516 0.006196
264 POSITIVE REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 2 16 0.0003516 0.006196
265 TUBE DEVELOPMENT 6 552 0.0003532 0.006202
266 HOMEOSTATIC PROCESS 9 1337 0.0003746 0.006552
267 REGULATION OF ENERGY HOMEOSTASIS 2 17 0.000398 0.006808
268 POSITIVE REGULATION OF GLYCOGEN METABOLIC PROCESS 2 17 0.000398 0.006808
269 MAMMARY GLAND ALVEOLUS DEVELOPMENT 2 17 0.000398 0.006808
270 MAMMARY GLAND LOBULE DEVELOPMENT 2 17 0.000398 0.006808
271 REGULATION OF TRANSLATIONAL INITIATION 3 82 0.0003955 0.006808
272 RESPONSE TO ALCOHOL 5 362 0.0003925 0.006808
273 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 7 801 0.0004056 0.006914
274 CIRCULATORY SYSTEM PROCESS 5 366 0.0004127 0.007008
275 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 5 368 0.0004231 0.007158
276 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 6 573 0.0004308 0.007263
277 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 5 370 0.0004337 0.007285
278 CELLULAR RESPONSE TO PROSTAGLANDIN E STIMULUS 2 18 0.0004473 0.007459
279 RESPONSE TO CAFFEINE 2 18 0.0004473 0.007459
280 LYMPHOCYTE DIFFERENTIATION 4 209 0.0004707 0.007821
281 REGULATION OF STEM CELL PROLIFERATION 3 88 0.0004866 0.008028
282 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 3 88 0.0004866 0.008028
283 REGULATION OF CELL CELL ADHESION 5 380 0.0004897 0.008052
284 REGULATION OF TRANSLATION IN RESPONSE TO STRESS 2 19 0.0004993 0.008181
285 EPITHELIAL CELL PROLIFERATION 3 89 0.0005029 0.008211
286 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 4 213 0.0005055 0.008224
287 REGULATION OF CELL DEVELOPMENT 7 836 0.0005244 0.008502
288 NEUROGENESIS 9 1402 0.000531 0.008579
289 CELLULAR RESPONSE TO LIGHT STIMULUS 3 91 0.0005367 0.008641
290 EMBRYONIC HEMOPOIESIS 2 20 0.0005542 0.008831
291 CELLULAR RESPONSE TO GROWTH HORMONE STIMULUS 2 20 0.0005542 0.008831
292 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 4 218 0.0005516 0.008831
293 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 6 602 0.0005594 0.008883
294 REGULATION OF PROTEIN STABILITY 4 221 0.0005807 0.00919
295 POSITIVE REGULATION OF ADHERENS JUNCTION ORGANIZATION 2 21 0.0006119 0.009618
296 REGULATED EXOCYTOSIS 4 224 0.0006108 0.009618
297 MORPHOGENESIS OF AN EPITHELIUM 5 400 0.000618 0.009683
298 CARDIOCYTE DIFFERENTIATION 3 96 0.0006275 0.009797
299 NEURON PROJECTION MORPHOGENESIS 5 402 0.0006321 0.009837
NumGOOverlapSizeP ValueAdj. P Value
1 KINASE ACTIVITY 24 842 1.879e-25 1.745e-22
2 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 24 992 9.302e-24 4.321e-21
3 PROTEIN SERINE THREONINE KINASE ACTIVITY 18 445 4.072e-21 1.261e-18
4 PROTEIN KINASE ACTIVITY 18 640 2.674e-18 6.21e-16
5 ADENYL NUCLEOTIDE BINDING 19 1514 5.676e-13 1.055e-10
6 RIBONUCLEOTIDE BINDING 20 1860 1.753e-12 2.714e-10
7 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 70 2.941e-11 3.903e-09
8 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 6 43 1.064e-10 1.236e-08
9 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 6 51 3.112e-10 3.212e-08
10 KINASE BINDING 11 606 3.89e-09 3.614e-07
11 KINASE REGULATOR ACTIVITY 7 186 2.9e-08 2.449e-06
12 ENZYME REGULATOR ACTIVITY 12 959 4.138e-08 3.204e-06
13 ENZYME BINDING 15 1737 6.915e-08 4.942e-06
14 MOLECULAR FUNCTION REGULATOR 13 1353 2.124e-07 1.41e-05
15 PROTEIN SERINE THREONINE TYROSINE KINASE ACTIVITY 4 39 6.187e-07 3.832e-05
16 INSULIN RECEPTOR SUBSTRATE BINDING 3 11 8.023e-07 4.658e-05
17 PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY 3 16 2.707e-06 0.0001479
18 PHOSPHATASE BINDING 5 162 8.742e-06 0.0004512
19 MAGNESIUM ION BINDING 5 199 2.362e-05 0.001097
20 INSULIN RECEPTOR BINDING 3 32 2.352e-05 0.001097
21 PROTEIN PHOSPHATASE BINDING 4 120 5.589e-05 0.002472
22 ENZYME ACTIVATOR ACTIVITY 6 471 0.0001502 0.006341
23 GROWTH FACTOR ACTIVITY 4 160 0.0001702 0.006696
24 KINASE ACTIVATOR ACTIVITY 3 62 0.000173 0.006696
NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 7 20 2.022e-15 1.181e-12
2 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 11 237 1.666e-13 4.864e-11
3 EXTRINSIC COMPONENT OF MEMBRANE 8 252 9.973e-09 1.941e-06
4 TRANSFERASE COMPLEX 11 703 1.808e-08 2.64e-06
5 CATALYTIC COMPLEX 11 1038 9.212e-07 0.0001076
6 PROTEIN KINASE COMPLEX 4 90 1.804e-05 0.001756
7 PRE AUTOPHAGOSOMAL STRUCTURE 3 31 2.134e-05 0.00178
8 PLATELET ALPHA GRANULE LUMEN 3 55 0.000121 0.008834

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04150_mTOR_signaling_pathway 35 52 6.799e-98 1.224e-95
2 hsa04151_PI3K_AKT_signaling_pathway 24 351 1.159e-34 1.043e-32
3 hsa04910_Insulin_signaling_pathway 19 138 8.851e-33 5.31e-31
4 hsa04914_Progesterone.mediated_oocyte_maturation 15 87 3.205e-27 1.442e-25
5 hsa04012_ErbB_signaling_pathway 13 87 1.069e-22 3.847e-21
6 hsa04722_Neurotrophin_signaling_pathway 14 127 1.719e-22 5.156e-21
7 hsa04510_Focal_adhesion 15 200 1.601e-21 4.117e-20
8 hsa04666_Fc_gamma_R.mediated_phagocytosis 12 95 4.899e-20 1.102e-18
9 hsa04960_Aldosterone.regulated_sodium_reabsorption 10 42 9.251e-20 1.85e-18
10 hsa04370_VEGF_signaling_pathway 11 76 4.347e-19 7.825e-18
11 hsa04973_Carbohydrate_digestion_and_absorption 9 44 3.411e-17 5.582e-16
12 hsa04662_B_cell_receptor_signaling_pathway 10 75 5.019e-17 7.529e-16
13 hsa04014_Ras_signaling_pathway 13 236 7.24e-17 1.002e-15
14 hsa04664_Fc_epsilon_RI_signaling_pathway 10 79 8.684e-17 1.116e-15
15 hsa04620_Toll.like_receptor_signaling_pathway 10 102 1.251e-15 1.501e-14
16 hsa04660_T_cell_receptor_signaling_pathway 10 108 2.258e-15 2.54e-14
17 hsa04380_Osteoclast_differentiation 10 128 1.293e-14 1.369e-13
18 hsa04210_Apoptosis 9 89 2.901e-14 2.901e-13
19 hsa04062_Chemokine_signaling_pathway 10 189 6.687e-13 6.335e-12
20 hsa04630_Jak.STAT_signaling_pathway 9 155 4.744e-12 4.27e-11
21 hsa04070_Phosphatidylinositol_signaling_system 7 78 6.418e-11 5.501e-10
22 hsa04650_Natural_killer_cell_mediated_cytotoxicity 8 136 7.489e-11 6.127e-10
23 hsa04670_Leukocyte_transendothelial_migration 7 117 1.148e-09 8.988e-09
24 hsa04810_Regulation_of_actin_cytoskeleton 8 214 2.768e-09 2.076e-08
25 hsa04140_Regulation_of_autophagy 5 34 3.268e-09 2.353e-08
26 hsa04114_Oocyte_meiosis 6 114 4.26e-08 2.949e-07
27 hsa04920_Adipocytokine_signaling_pathway 5 68 1.173e-07 7.823e-07
28 hsa04720_Long.term_potentiation 5 70 1.359e-07 8.736e-07
29 hsa04010_MAPK_signaling_pathway 7 268 3.5e-07 2.173e-06
30 hsa00562_Inositol_phosphate_metabolism 3 57 0.0001346 0.0008078
31 hsa04350_TGF.beta_signaling_pathway 3 85 0.0004395 0.002552
32 hsa04730_Long.term_depression 2 70 0.006669 0.03751
33 hsa04530_Tight_junction 2 133 0.02263 0.1234
34 hsa03013_RNA_transport 2 152 0.02898 0.1534

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

RFPL1S

 hsa-miR-106b-5p;hsa-miR-107;hsa-miR-17-3p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-320b;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-505-3p 11 AKT3 Sponge network -0.223 0.70704 -0.749 0.06936 0.466
2

MEG3

 hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-320b;hsa-miR-33a-3p;hsa-miR-3662;hsa-miR-577;hsa-miR-592;hsa-miR-629-5p 13 IGF1 Sponge network -1.645 0.00049 -2.083 0.00135 0.434
3

PCA3

 hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-181b-5p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-27a-3p;hsa-miR-301a-3p;hsa-miR-32-3p;hsa-miR-320b;hsa-miR-33a-3p;hsa-miR-3662;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-629-5p;hsa-miR-940 24 IGF1 Sponge network -2.778 8.0E-5 -2.083 0.00135 0.404
4

EMX2OS

 hsa-miR-107;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-32-3p;hsa-miR-335-3p;hsa-miR-362-3p;hsa-miR-501-3p;hsa-miR-502-3p;hsa-miR-505-3p;hsa-miR-577 12 AKT3 Sponge network -1.088 0.10042 -0.749 0.06936 0.354
5

AGAP11

 hsa-let-7d-5p;hsa-let-7f-1-3p;hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-146a-5p;hsa-miR-15b-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-192-5p;hsa-miR-19a-3p;hsa-miR-20a-5p;hsa-miR-335-3p 12 PRKAA2 Sponge network -1.728 0.00016 -3.711 4.0E-5 0.344
6

AGAP11

 hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-181b-5p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-320b;hsa-miR-3662;hsa-miR-421;hsa-miR-629-5p 14 IGF1 Sponge network -1.728 0.00016 -2.083 0.00135 0.332
7

EMX2OS

 hsa-let-7d-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-192-5p;hsa-miR-19a-3p;hsa-miR-20a-5p;hsa-miR-21-3p;hsa-miR-335-3p;hsa-miR-577;hsa-miR-7-1-3p 12 PRKAA2 Sponge network -1.088 0.10042 -3.711 4.0E-5 0.325
8

MEG3

 hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-577;hsa-miR-616-5p 11 AKT3 Sponge network -1.645 0.00049 -0.749 0.06936 0.312
9

PCA3

 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-107;hsa-miR-128-3p;hsa-miR-144-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-185-5p;hsa-miR-188-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-22-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-32-3p;hsa-miR-320b;hsa-miR-324-3p;hsa-miR-330-3p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-96-5p 28 PIK3R1 Sponge network -2.778 8.0E-5 -1.094 2.0E-5 0.309
10

MEG3

 hsa-let-7d-5p;hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-20a-5p;hsa-miR-31-5p;hsa-miR-335-3p;hsa-miR-577;hsa-miR-7-1-3p 12 PRKAA2 Sponge network -1.645 0.00049 -3.711 4.0E-5 0.287

Quest ID: 58a054725fc5c96bf457868f58dbfa5b