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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-17-5p ABCD2 2.33 0.30125 -2.73 0.01225 MirTarget -0.54 0 NA
2 hsa-miR-17-5p ABHD2 2.33 0.30125 0.09 0.9591 TargetScan; miRNATAP -0.18 0.00209 NA
3 hsa-miR-32-5p ABI3BP 2.95 0.02657 -4.96 5.0E-5 miRNATAP -0.32 0.02411 NA
4 hsa-miR-32-5p ABLIM1 2.95 0.02657 -0.22 0.91084 mirMAP -0.34 1.0E-5 NA
5 hsa-miR-454-3p ACSL1 1.37 0.14233 -0.18 0.89649 MirTarget -0.21 0.00407 NA
6 hsa-miR-454-3p ACSL4 1.37 0.14233 -0.96 0.51944 MirTarget; miRNATAP -0.14 0.04315 NA
7 hsa-miR-32-5p ACTC1 2.95 0.02657 -6.29 2.0E-5 MirTarget -0.56 0.00053 NA
8 hsa-miR-454-3p ACVR1 1.37 0.14233 -0.76 0.54869 MirTarget; miRNATAP -0.12 0.00599 NA
9 hsa-miR-17-5p ACVRL1 2.33 0.30125 -3.43 0.00079 TargetScan -0.23 0.0002 NA
10 hsa-miR-32-5p ADAM22 2.95 0.02657 -1.98 0.10406 mirMAP -0.36 0.01652 NA
11 hsa-miR-17-5p ADAMTS5 2.33 0.30125 -6.31 0 TargetScan -0.22 0.02546 NA
12 hsa-miR-32-5p ADAMTSL1 2.95 0.02657 -6 0 miRNATAP -0.53 4.0E-5 NA
13 hsa-miR-32-5p ADAMTSL3 2.95 0.02657 -3.45 0.01443 MirTarget; miRNATAP -0.53 0.00122 NA
14 hsa-miR-32-5p ADCY1 2.95 0.02657 -1.25 0.23905 mirMAP -0.28 0.02311 NA
15 hsa-miR-32-5p ADCY5 2.95 0.02657 -5.82 0.00016 mirMAP -0.46 0.01573 NA
16 hsa-miR-17-5p AFF1 2.33 0.30125 -1.07 0.49725 TargetScan -0.11 0.00674 NA
17 hsa-miR-32-5p AFF3 2.95 0.02657 -4.85 0 MirTarget -0.43 0.00013 NA
18 hsa-miR-17-5p AGFG2 2.33 0.30125 -1.28 0.29482 TargetScan; miRNATAP -0.19 1.0E-5 NA
19 hsa-miR-32-5p AHCYL1 2.95 0.02657 -0.31 0.86149 miRNATAP -0.12 0.00017 NA
20 hsa-miR-17-5p AHNAK 2.33 0.30125 -1.04 0.64703 TargetScan; miRNATAP -0.18 0.00111 NA
21 hsa-miR-454-3p AKAP11 1.37 0.14233 -0.66 0.63974 miRNATAP -0.12 0.00898 NA
22 hsa-miR-32-5p AKAP12 2.95 0.02657 -4.74 0.00166 mirMAP -0.46 0.00052 NA
23 hsa-miR-17-5p AKAP13 2.33 0.30125 -1.53 0.37244 MirTarget; TargetScan; mirMAP; miRNATAP -0.19 0 NA
24 hsa-miR-17-5p AKT3 2.33 0.30125 -3.26 0.00117 TargetScan; miRNATAP -0.17 0.02914 NA
25 hsa-miR-32-5p ALPK3 2.95 0.02657 0.54 0.75673 miRNATAP -0.48 0.00131 NA
26 hsa-miR-454-3p AMPD3 1.37 0.14233 1.49 0.13818 MirTarget; miRNATAP -0.28 3.0E-5 NA
27 hsa-miR-32-5p ANGPTL2 2.95 0.02657 -3.08 0.01213 miRNATAP -0.35 5.0E-5 NA
28 hsa-miR-17-5p ANK2 2.33 0.30125 -5.43 0 MirTarget; miRNATAP -0.6 0 NA
29 hsa-miR-32-5p ANK3 2.95 0.02657 -0.06 0.96651 MirTarget -0.27 0.00066 NA
30 hsa-miR-454-3p ANKRD12 1.37 0.14233 -0.46 0.71724 MirTarget; miRNATAP -0.11 0.01667 NA
31 hsa-miR-17-5p ANKRD29 2.33 0.30125 -2.22 0.05518 MirTarget; TargetScan -0.54 0 NA
32 hsa-miR-17-5p ANKRD50 2.33 0.30125 0 0.99734 MirTarget; TargetScan; miRNATAP -0.16 0.00363 NA
33 hsa-miR-17-5p ANXA11 2.33 0.30125 -0.04 0.98232 mirMAP -0.11 0.00676 NA
34 hsa-miR-32-5p APCDD1L 2.95 0.02657 -1.02 0.55328 mirMAP -0.64 0.00057 NA
35 hsa-miR-32-5p APPL1 2.95 0.02657 -0.48 0.73603 miRNAWalker2 validate; MirTarget -0.12 0.0043 NA
36 hsa-miR-17-5p AR 2.33 0.30125 -4.67 0.00218 mirMAP -0.79 0 23095762 miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells
37 hsa-miR-454-3p AR 1.37 0.14233 -4.67 0.00218 mirMAP; miRNATAP -0.47 0.00625 NA
38 hsa-miR-17-5p ARAP2 2.33 0.30125 1.85 0.12177 MirTarget; TargetScan -0.14 0.01554 NA
39 hsa-miR-454-3p ARAP2 1.37 0.14233 1.85 0.12177 MirTarget -0.2 0.00207 NA
40 hsa-miR-454-3p ARHGAP21 1.37 0.14233 -0.06 0.96644 MirTarget; miRNATAP -0.14 0.01042 NA
41 hsa-miR-17-5p ARHGAP24 2.33 0.30125 -1.57 0.12603 MirTarget -0.23 0.01058 NA
42 hsa-miR-17-5p ARHGAP26 2.33 0.30125 -0.19 0.90211 MirTarget; TargetScan; mirMAP; miRNATAP -0.23 0.00209 NA
43 hsa-miR-17-5p ARHGAP31 2.33 0.30125 -2.29 0.00905 TargetScan -0.3 0 NA
44 hsa-miR-454-3p ARHGEF12 1.37 0.14233 -0.46 0.79305 MirTarget; miRNATAP -0.16 0.0003 NA
45 hsa-miR-32-5p ARHGEF17 2.95 0.02657 -2.26 0.08671 miRNATAP -0.26 1.0E-5 NA
46 hsa-miR-17-5p ARHGEF3 2.33 0.30125 -1.01 0.44523 MirTarget; TargetScan; miRNATAP -0.16 0.00015 NA
47 hsa-miR-32-5p ARL10 2.95 0.02657 -0.54 0.50161 mirMAP -0.28 0.00371 NA
48 hsa-miR-17-5p ARL4C 2.33 0.30125 1.91 0.17875 MirTarget; TargetScan; miRNATAP -0.15 0.03095 NA
49 hsa-miR-17-5p ARSD 2.33 0.30125 0 0.99908 mirMAP -0.32 0 NA
50 hsa-miR-17-5p ASPA 2.33 0.30125 -5.59 0.00012 mirMAP -0.55 1.0E-5 NA
51 hsa-miR-454-3p ASPA 1.37 0.14233 -5.59 0.00012 mirMAP -0.32 0.02559 NA
52 hsa-miR-454-3p ASXL2 1.37 0.14233 0.94 0.44816 MirTarget; miRNATAP -0.2 0.03105 NA
53 hsa-miR-17-5p ASXL3 2.33 0.30125 -4.32 0.00164 TargetScan -0.39 0.00638 NA
54 hsa-miR-17-5p ATF3 2.33 0.30125 -0.68 0.67723 miRNAWalker2 validate -0.18 0.03451 NA
55 hsa-miR-17-5p ATOH8 2.33 0.30125 -5.62 0 TargetScan -0.36 0.00027 NA
56 hsa-miR-17-5p ATP1A2 2.33 0.30125 -7.07 0 MirTarget; TargetScan -0.72 0 NA
57 hsa-miR-32-5p ATP2B4 2.95 0.02657 -2.02 0.23283 MirTarget -0.16 0.00505 NA
58 hsa-miR-454-3p ATP6V1B2 1.37 0.14233 0.31 0.84053 MirTarget; miRNATAP -0.1 0.00585 NA
59 hsa-miR-32-5p ATP7A 2.95 0.02657 0.03 0.97947 miRNATAP -0.12 0.02029 NA
60 hsa-miR-32-5p ATP8B1 2.95 0.02657 0.87 0.59803 miRNATAP -0.16 0.0112 NA
61 hsa-miR-17-5p ATXN1 2.33 0.30125 -1.44 0.25265 TargetScan; miRNATAP -0.19 0.00016 NA
62 hsa-miR-32-5p ATXN1 2.95 0.02657 -1.44 0.25265 miRNAWalker2 validate; miRNATAP -0.13 0.03284 NA
63 hsa-miR-454-3p ATXN1 1.37 0.14233 -1.44 0.25265 miRNATAP -0.17 0.00303 NA
64 hsa-miR-32-5p ATXN1L 2.95 0.02657 -0.17 0.89808 miRNATAP -0.14 0.00438 NA
65 hsa-miR-17-5p ATXN7L1 2.33 0.30125 -0.26 0.74464 TargetScan -0.18 0 NA
66 hsa-miR-32-5p BAZ2B 2.95 0.02657 -0.62 0.62222 miRNATAP -0.12 0.00596 NA
67 hsa-miR-454-3p BBX 1.37 0.14233 -0.17 0.90638 MirTarget; miRNATAP -0.1 0.02182 NA
68 hsa-miR-17-5p BCAS1 2.33 0.30125 -0.49 0.78808 mirMAP -0.86 0 NA
69 hsa-miR-17-5p BCL6 2.33 0.30125 -0.43 0.75836 TargetScan -0.16 0.0008 NA
70 hsa-miR-32-5p BCL9 2.95 0.02657 -1.03 0.45216 miRNATAP -0.11 0.02473 NA
71 hsa-miR-454-3p BCL9L 1.37 0.14233 -0.07 0.96468 mirMAP -0.14 0.00577 NA
72 hsa-miR-454-3p BHLHE40 1.37 0.14233 1.11 0.56907 miRNAWalker2 validate -0.24 0.00086 NA
73 hsa-miR-17-5p BHLHE41 2.33 0.30125 -1.42 0.31661 TargetScan; miRNATAP -0.44 1.0E-5 NA
74 hsa-miR-17-5p BICC1 2.33 0.30125 -2.29 0.08377 TargetScan -0.31 0.02277 NA
75 hsa-miR-32-5p BICD1 2.95 0.02657 -0.03 0.97414 mirMAP -0.21 0.00629 NA
76 hsa-miR-17-5p BMPR2 2.33 0.30125 -1.14 0.45199 miRNAWalker2 validate; MirTarget; TargetScan; miRNATAP -0.12 0.00049 NA
77 hsa-miR-32-5p BMPR2 2.95 0.02657 -1.14 0.45199 miRNATAP -0.15 0.00016 NA
78 hsa-miR-17-5p BNC2 2.33 0.30125 -6.05 0 TargetScan; miRNATAP -0.58 0 NA
79 hsa-miR-32-5p BRMS1L 2.95 0.02657 0.09 0.91727 miRNATAP -0.11 0.03586 NA
80 hsa-miR-454-3p BRWD3 1.37 0.14233 2.17 0.04658 MirTarget; miRNATAP -0.2 0.01287 NA
81 hsa-miR-454-3p BTBD10 1.37 0.14233 0.53 0.66167 MirTarget -0.18 3.0E-5 NA
82 hsa-miR-17-5p BTG1 2.33 0.30125 -0.79 0.64588 TargetScan -0.12 0.00371 NA
83 hsa-miR-454-3p BTG1 1.37 0.14233 -0.79 0.64588 miRNATAP -0.11 0.02771 NA
84 hsa-miR-17-5p BTG2 2.33 0.30125 -1.97 0.25098 TargetScan -0.11 0.04449 NA
85 hsa-miR-32-5p BTG2 2.95 0.02657 -1.97 0.25098 MirTarget; miRNATAP -0.17 0.0116 22266859 Androgen regulated miR 32 targets BTG2 and is overexpressed in castration resistant prostate cancer; In conclusion androgen-regulated miR-32 is overexpressed in CRPC leading to reduced expression of BTG2
86 hsa-miR-17-5p BTN3A1 2.33 0.30125 -0.3 0.82105 miRNAWalker2 validate -0.24 0.00014 NA
87 hsa-miR-409-3p BTN3A2 0.28 0.79947 -0.05 0.97293 mirMAP -0.13 0.01301 NA
88 hsa-miR-17-5p C14orf28 2.33 0.30125 -2.37 0.00011 TargetScan; miRNATAP -0.23 0 NA
89 hsa-miR-454-3p C15orf52 1.37 0.14233 -1.25 0.3319 mirMAP -0.36 0.00077 NA
90 hsa-miR-454-3p C1S 1.37 0.14233 -1.82 0.27315 MirTarget -0.25 0.01612 NA
91 hsa-miR-409-3p C1orf21 0.28 0.79947 -1.12 0.41646 PITA; mirMAP -0.13 0.02071 NA
92 hsa-miR-32-5p C1orf64 2.95 0.02657 -2.7 0.12441 mirMAP -0.41 0.01751 NA
93 hsa-miR-32-5p C20orf194 2.95 0.02657 -1.84 0.07639 miRNATAP -0.27 2.0E-5 NA
94 hsa-miR-17-5p C3orf70 2.33 0.30125 -3.26 0.00156 TargetScan -0.21 0.04273 NA
95 hsa-miR-17-5p CA10 2.33 0.30125 -3.64 0.02709 miRNATAP -0.33 0.02235 NA
96 hsa-miR-32-5p CACNA1H 2.95 0.02657 -6.12 0 miRNATAP -0.51 1.0E-5 NA
97 hsa-miR-32-5p CADM1 2.95 0.02657 -2.09 0.1387 miRNATAP -0.3 0.02273 NA
98 hsa-miR-17-5p CALD1 2.33 0.30125 -3.71 0.02146 TargetScan; miRNATAP -0.21 0.00428 NA
99 hsa-miR-32-5p CALN1 2.95 0.02657 -3.12 0.07468 miRNATAP -0.61 0.00053 NA
100 hsa-miR-32-5p CAMK2A 2.95 0.02657 -4.27 0.00179 MirTarget -0.38 0.00666 NA
101 hsa-miR-17-5p CAPN5 2.33 0.30125 -1.94 0.26998 mirMAP -0.37 0.00205 NA
102 hsa-miR-17-5p CASC4 2.33 0.30125 -1.45 0.37749 MirTarget -0.14 0.0007 NA
103 hsa-miR-32-5p CBFA2T2 2.95 0.02657 0.58 0.68302 mirMAP -0.15 0.00298 NA
104 hsa-miR-17-5p CBX7 2.33 0.30125 -3.22 0.00976 mirMAP -0.32 0 NA
105 hsa-miR-454-3p CD109 1.37 0.14233 0.41 0.73596 mirMAP -0.3 0.02391 NA
106 hsa-miR-17-5p CD226 2.33 0.30125 0.6 0.47807 TargetScan -0.32 6.0E-5 NA
107 hsa-miR-17-5p CD69 2.33 0.30125 -0.62 0.5233 TargetScan; miRNATAP -0.44 0 NA
108 hsa-miR-454-3p CD69 1.37 0.14233 -0.62 0.5233 miRNATAP -0.25 0.01834 NA
109 hsa-miR-454-3p CDH11 1.37 0.14233 -2.75 0.04281 mirMAP -0.48 7.0E-5 NA
110 hsa-miR-17-5p CELF2 2.33 0.30125 -2.38 0.01903 TargetScan -0.3 0.00014 NA
111 hsa-miR-17-5p CHD9 2.33 0.30125 -0.24 0.84856 MirTarget; TargetScan; miRNATAP -0.17 7.0E-5 NA
112 hsa-miR-32-5p CHD9 2.95 0.02657 -0.24 0.84856 miRNATAP -0.2 4.0E-5 NA
113 hsa-miR-454-3p CHD9 1.37 0.14233 -0.24 0.84856 miRNATAP -0.17 0.00054 NA
114 hsa-miR-17-5p CHIC1 2.33 0.30125 -1.78 0.08872 TargetScan -0.26 5.0E-5 NA
115 hsa-miR-17-5p CIITA 2.33 0.30125 0.67 0.63916 mirMAP -0.21 0.04302 NA
116 hsa-miR-32-5p CLDN11 2.95 0.02657 -3.47 0.00112 MirTarget -0.36 0.00427 NA
117 hsa-miR-17-5p CLIC6 2.33 0.30125 -0.19 0.92919 mirMAP -0.47 0.00962 NA
118 hsa-miR-454-3p CLIP1 1.37 0.14233 0.42 0.78033 MirTarget; miRNATAP -0.21 7.0E-5 NA
119 hsa-miR-409-3p CLYBL 0.28 0.79947 -0.96 0.26882 miRNATAP -0.14 0.0173 NA
120 hsa-miR-17-5p CMKLR1 2.33 0.30125 -2.3 0.0139 TargetScan -0.35 9.0E-5 NA
121 hsa-miR-17-5p CNN1 2.33 0.30125 -8.99 0 TargetScan -0.71 0 NA
122 hsa-miR-32-5p CNTN1 2.95 0.02657 -2.59 0.16326 miRNATAP -0.82 0.00019 NA
123 hsa-miR-32-5p CNTN4 2.95 0.02657 -4.67 6.0E-5 miRNATAP -0.67 0 NA
124 hsa-miR-32-5p COL11A1 2.95 0.02657 -0.69 0.72488 MirTarget -0.8 0.00046 NA
125 hsa-miR-32-5p COL12A1 2.95 0.02657 -2.11 0.24462 miRNATAP -0.38 0.00145 NA
126 hsa-miR-17-5p COL1A1 2.33 0.30125 -1.82 0.45918 mirMAP -0.33 0.00039 NA
127 hsa-miR-32-5p COL1A2 2.95 0.02657 -2.4 0.30049 MirTarget; miRNATAP -0.62 0 NA
128 hsa-miR-32-5p COL5A1 2.95 0.02657 -2.17 0.20473 miRNATAP -0.29 0.01728 NA
129 hsa-miR-17-5p COL8A2 2.33 0.30125 -0.42 0.72104 mirMAP -0.23 0.01147 NA
130 hsa-miR-17-5p CORO2B 2.33 0.30125 -3.77 0.00099 MirTarget; TargetScan; miRNATAP -0.33 0.00536 NA
131 hsa-miR-454-3p CPEB2 1.37 0.14233 -0.45 0.66859 miRNATAP -0.16 0.01428 NA
132 hsa-miR-17-5p CPEB3 2.33 0.30125 -0.09 0.91502 TargetScan; miRNATAP -0.21 5.0E-5 NA
133 hsa-miR-32-5p CPEB3 2.95 0.02657 -0.09 0.91502 MirTarget; miRNATAP -0.15 0.01492 NA
134 hsa-miR-17-5p CPEB4 2.33 0.30125 -0.68 0.57172 mirMAP -0.18 0.00148 NA
135 hsa-miR-32-5p CPEB4 2.95 0.02657 -0.68 0.57172 miRNAWalker2 validate; miRNATAP -0.22 0.00068 NA
136 hsa-miR-454-3p CPEB4 1.37 0.14233 -0.68 0.57172 miRNATAP -0.16 0.01341 NA
137 hsa-miR-17-5p CREB3L2 2.33 0.30125 -2.18 0.1571 mirMAP -0.14 0.02334 NA
138 hsa-miR-454-3p CRISPLD1 1.37 0.14233 -3.16 0.0237 MirTarget -0.4 0.01665 NA
139 hsa-miR-17-5p CROT 2.33 0.30125 0.76 0.43857 MirTarget -0.29 0 NA
140 hsa-miR-17-5p CRY2 2.33 0.30125 -2.56 0.03317 MirTarget; TargetScan; miRNATAP -0.14 6.0E-5 NA
141 hsa-miR-17-5p CRYBG3 2.33 0.30125 -0.03 0.98149 MirTarget; TargetScan; miRNATAP -0.24 0.00055 NA
142 hsa-miR-17-5p CSF1 2.33 0.30125 -0.95 0.36961 TargetScan; miRNATAP -0.15 0.04971 NA
143 hsa-miR-454-3p CSF1 1.37 0.14233 -0.95 0.36961 MirTarget; miRNATAP -0.2 0.02018 NA
144 hsa-miR-32-5p CTNNBIP1 2.95 0.02657 1.15 0.41935 miRNATAP -0.1 0.04497 NA
145 hsa-miR-17-5p CTSK 2.33 0.30125 -3.24 0.01457 MirTarget -0.57 0 NA
146 hsa-miR-454-3p CTSK 1.37 0.14233 -3.24 0.01457 MirTarget -0.47 0 NA
147 hsa-miR-32-5p CTTNBP2 2.95 0.02657 -5.52 7.0E-5 miRNATAP -0.39 0.02053 NA
148 hsa-miR-17-5p CXCL14 2.33 0.30125 2.15 0.29887 TargetScan -0.63 0.00031 NA
149 hsa-miR-32-5p CXXC5 2.95 0.02657 -0.03 0.98488 MirTarget -0.46 0 NA
150 hsa-miR-17-5p CXorf23 2.33 0.30125 -0.34 0.66995 mirMAP -0.11 0.00156 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 TISSUE DEVELOPMENT 119 1518 2.018e-16 9.392e-13
2 REGULATION OF CELL DIFFERENTIATION 115 1492 2.396e-15 3.538e-12
3 CARDIOVASCULAR SYSTEM DEVELOPMENT 76 788 3.041e-15 3.538e-12
4 CIRCULATORY SYSTEM DEVELOPMENT 76 788 3.041e-15 3.538e-12
5 CELL DEVELOPMENT 110 1426 1.028e-14 9.567e-12
6 NEUROGENESIS 108 1402 2.056e-14 1.594e-11
7 ORGAN MORPHOGENESIS 76 841 9.374e-14 6.231e-11
8 MUSCLE TISSUE DEVELOPMENT 39 275 1.989e-13 1.157e-10
9 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 84 1008 3.727e-13 1.927e-10
10 POSITIVE REGULATION OF GENE EXPRESSION 121 1733 4.781e-13 2.224e-10
11 TISSUE MORPHOGENESIS 56 533 5.344e-13 2.26e-10
12 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 123 1805 1.584e-12 6.143e-10
13 POSITIVE REGULATION OF MOLECULAR FUNCTION 122 1791 2.044e-12 7.316e-10
14 HEART DEVELOPMENT 50 466 4.546e-12 1.511e-09
15 NEURON DIFFERENTIATION 74 874 5.028e-12 1.56e-09
16 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 123 1848 7.799e-12 2.268e-09
17 EMBRYONIC MORPHOGENESIS 54 539 9.133e-12 2.5e-09
18 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 114 1672 1.185e-11 3.063e-09
19 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 112 1656 3.064e-11 7.128e-09
20 RESPONSE TO ENDOGENOUS STIMULUS 102 1450 2.918e-11 7.128e-09
21 MUSCLE STRUCTURE DEVELOPMENT 46 432 4.34e-11 9.616e-09
22 VASCULATURE DEVELOPMENT 48 469 6.508e-11 1.377e-08
23 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 117 1784 7.132e-11 1.443e-08
24 SKELETAL SYSTEM DEVELOPMENT 47 455 7.55e-11 1.464e-08
25 POSITIVE REGULATION OF CATALYTIC ACTIVITY 104 1518 8.422e-11 1.568e-08
26 EMBRYO DEVELOPMENT 72 894 9.945e-11 1.714e-08
27 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 28 184 9.618e-11 1.714e-08
28 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 35 278 1.052e-10 1.748e-08
29 EMBRYONIC ORGAN MORPHOGENESIS 35 279 1.163e-10 1.866e-08
30 REGULATION OF GTPASE ACTIVITY 59 673 2.175e-10 3.373e-08
31 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 74 957 3.423e-10 5.139e-08
32 CENTRAL NERVOUS SYSTEM DEVELOPMENT 69 872 5.365e-10 7.801e-08
33 INTRACELLULAR SIGNAL TRANSDUCTION 104 1572 6.075e-10 8.566e-08
34 POSITIVE REGULATION OF CELL COMMUNICATION 102 1532 6.458e-10 8.838e-08
35 BIOLOGICAL ADHESION 77 1032 7.535e-10 1.002e-07
36 REGULATION OF SYSTEM PROCESS 48 507 9.202e-10 1.189e-07
37 NEURON DEVELOPMENT 58 687 1.3e-09 1.634e-07
38 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 48 513 1.359e-09 1.664e-07
39 MORPHOGENESIS OF AN EPITHELIUM 41 400 1.586e-09 1.892e-07
40 TUBE DEVELOPMENT 50 552 1.841e-09 2.142e-07
41 POSITIVE REGULATION OF CELL DIFFERENTIATION 65 823 1.898e-09 2.154e-07
42 EMBRYONIC ORGAN DEVELOPMENT 41 406 2.462e-09 2.727e-07
43 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 74 1004 2.828e-09 3.06e-07
44 NEURON PROJECTION DEVELOPMENT 49 545 3.435e-09 3.633e-07
45 REGULATION OF CELL DEVELOPMENT 65 836 3.538e-09 3.658e-07
46 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 24 162 3.648e-09 3.69e-07
47 CARDIAC MUSCLE TISSUE DEVELOPMENT 22 140 5.339e-09 5.285e-07
48 TUBE MORPHOGENESIS 35 323 6.047e-09 5.862e-07
49 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 80 1142 6.174e-09 5.862e-07
50 EPITHELIUM DEVELOPMENT 70 945 6.402e-09 5.957e-07
51 POSITIVE REGULATION OF RESPONSE TO STIMULUS 117 1929 7.555e-09 6.76e-07
52 POSITIVE REGULATION OF CELL DEVELOPMENT 44 472 7.509e-09 6.76e-07
53 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 62 799 8.952e-09 7.86e-07
54 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 62 801 9.833e-09 8.473e-07
55 REGULATION OF PHOSPHORUS METABOLIC PROCESS 102 1618 1.176e-08 9.95e-07
56 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 73 1021 1.308e-08 1.087e-06
57 REGULATION OF PROTEIN MODIFICATION PROCESS 106 1710 1.413e-08 1.138e-06
58 REGULATION OF CELLULAR COMPONENT MOVEMENT 60 771 1.418e-08 1.138e-06
59 ACTIN FILAMENT BASED PROCESS 42 450 1.6e-08 1.262e-06
60 CELL CELL ADHESION 51 608 1.658e-08 1.286e-06
61 NEGATIVE REGULATION OF CELL DIFFERENTIATION 51 609 1.749e-08 1.334e-06
62 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 85 1275 1.956e-08 1.468e-06
63 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 55 689 2.478e-08 1.83e-06
64 CELLULAR COMPONENT MORPHOGENESIS 66 900 2.628e-08 1.911e-06
65 SENSORY ORGAN DEVELOPMENT 44 493 2.743e-08 1.964e-06
66 MUSCLE CELL DIFFERENTIATION 28 237 3.178e-08 2.241e-06
67 CELLULAR RESPONSE TO HORMONE STIMULUS 47 552 3.906e-08 2.713e-06
68 BLOOD VESSEL MORPHOGENESIS 36 364 3.999e-08 2.736e-06
69 LOCOMOTION 76 1114 4.636e-08 3.126e-06
70 CARDIOCYTE DIFFERENTIATION 17 96 4.787e-08 3.182e-06
71 NEURON PROJECTION MORPHOGENESIS 38 402 5.581e-08 3.658e-06
72 REGULATION OF HYDROLASE ACTIVITY 86 1327 5.724e-08 3.699e-06
73 POSITIVE REGULATION OF HYDROLASE ACTIVITY 65 905 7.324e-08 4.669e-06
74 NEGATIVE REGULATION OF CELL COMMUNICATION 79 1192 8.35e-08 5.251e-06
75 POSITIVE REGULATION OF CELL DEATH 49 605 9.46e-08 5.869e-06
76 NEGATIVE REGULATION OF GENE EXPRESSION 93 1493 9.946e-08 6.068e-06
77 RESPONSE TO HORMONE 64 893 1.004e-07 6.068e-06
78 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 25 207 1.126e-07 6.63e-06
79 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 56 740 1.125e-07 6.63e-06
80 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 46 554 1.147e-07 6.67e-06
81 HOMOPHILIC CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 21 153 1.323e-07 7.599e-06
82 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 86 1360 1.679e-07 9.526e-06
83 HEART MORPHOGENESIS 25 212 1.792e-07 1.005e-05
84 POSITIVE REGULATION OF NEURON DIFFERENTIATION 31 306 2.058e-07 1.14e-05
85 NEGATIVE REGULATION OF CELL PROLIFERATION 50 643 2.437e-07 1.334e-05
86 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 87 1395 2.572e-07 1.392e-05
87 STRIATED MUSCLE CELL DIFFERENTIATION 22 173 2.62e-07 1.401e-05
88 CARDIAC MUSCLE CELL DIFFERENTIATION 14 74 3.121e-07 1.65e-05
89 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 67 983 3.183e-07 1.664e-05
90 REGULATION OF RHO PROTEIN SIGNAL TRANSDUCTION 17 109 3.248e-07 1.679e-05
91 CELL CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 24 204 3.289e-07 1.682e-05
92 HEAD DEVELOPMENT 53 709 3.651e-07 1.847e-05
93 CELLULAR RESPONSE TO NITROGEN COMPOUND 42 505 3.935e-07 1.969e-05
94 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 16 99 4.37e-07 2.118e-05
95 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 16 99 4.37e-07 2.118e-05
96 REGULATION OF OSSIFICATION 22 178 4.318e-07 2.118e-05
97 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 34 368 4.77e-07 2.288e-05
98 POSITIVE REGULATION OF LOCOMOTION 37 420 4.872e-07 2.313e-05
99 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 32 337 5.662e-07 2.661e-05
100 RESPONSE TO OXYGEN CONTAINING COMPOUND 85 1381 6.208e-07 2.888e-05
101 CELL PROJECTION ORGANIZATION 62 902 6.772e-07 3.12e-05
102 SKELETAL SYSTEM MORPHOGENESIS 23 201 9.425e-07 4.3e-05
103 REGULATION OF ACTIN FILAMENT BASED PROCESS 30 312 9.801e-07 4.427e-05
104 REGULATION OF CELL DEATH 88 1472 1.308e-06 5.85e-05
105 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 22 190 1.325e-06 5.871e-05
106 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 90 1517 1.346e-06 5.909e-05
107 REGULATION OF CELL ADHESION 47 629 1.719e-06 7.405e-05
108 SENSORY ORGAN MORPHOGENESIS 25 239 1.717e-06 7.405e-05
109 REGULATION OF NEURON DIFFERENTIATION 43 554 1.802e-06 7.692e-05
110 EAR MORPHOGENESIS 16 112 2.388e-06 0.000101
111 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 59 876 2.434e-06 0.000102
112 TELENCEPHALON DEVELOPMENT 24 228 2.468e-06 0.0001025
113 MUSCLE ORGAN DEVELOPMENT 27 277 2.619e-06 0.0001078
114 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 24 229 2.665e-06 0.0001088
115 REGULATION OF SODIUM ION TRANSPORT 13 77 3.163e-06 0.000128
116 BONE DEVELOPMENT 19 156 3.26e-06 0.0001308
117 RHYTHMIC PROCESS 28 298 3.51e-06 0.0001396
118 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 66 1036 4.005e-06 0.0001566
119 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 66 1036 4.005e-06 0.0001566
120 BEHAVIOR 40 516 4.26e-06 0.0001652
121 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 52 750 4.339e-06 0.0001669
122 INNER EAR MORPHOGENESIS 14 92 4.757e-06 0.0001814
123 CELL MOTILITY 56 835 5.022e-06 0.0001884
124 LOCALIZATION OF CELL 56 835 5.022e-06 0.0001884
125 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 71 1152 5.386e-06 0.0002005
126 CARTILAGE DEVELOPMENT 18 147 5.448e-06 0.0002012
127 FOREBRAIN DEVELOPMENT 31 357 5.507e-06 0.0002018
128 PROTEIN PHOSPHORYLATION 61 944 6.09e-06 0.0002214
129 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 12 70 6.401e-06 0.0002309
130 CONNECTIVE TISSUE DEVELOPMENT 21 194 6.707e-06 0.0002401
131 EAR DEVELOPMENT 21 195 7.269e-06 0.0002562
132 REGULATION OF MUSCLE SYSTEM PROCESS 21 195 7.269e-06 0.0002562
133 ANGIOGENESIS 27 293 7.489e-06 0.0002616
134 CARDIAC CELL DEVELOPMENT 10 49 7.535e-06 0.0002616
135 MULTICELLULAR ORGANISMAL SIGNALING 16 123 8.244e-06 0.0002842
136 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 35 437 8.386e-06 0.0002869
137 FORMATION OF PRIMARY GERM LAYER 15 110 8.791e-06 0.0002986
138 CIRCULATORY SYSTEM PROCESS 31 366 9.096e-06 0.0003059
139 REGULATION OF CELL MORPHOGENESIS 41 552 9.138e-06 0.0003059
140 APPENDAGE DEVELOPMENT 19 169 1.059e-05 0.0003494
141 LIMB DEVELOPMENT 19 169 1.059e-05 0.0003494
142 UROGENITAL SYSTEM DEVELOPMENT 27 299 1.085e-05 0.0003555
143 CELL JUNCTION ORGANIZATION 20 185 1.127e-05 0.0003666
144 RESPONSE TO NITROGEN COMPOUND 56 859 1.15e-05 0.0003715
145 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 69 1135 1.159e-05 0.0003718
146 MUSCLE CELL DEVELOPMENT 16 128 1.377e-05 0.0004368
147 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 27 303 1.38e-05 0.0004368
148 EXTRACELLULAR STRUCTURE ORGANIZATION 27 304 1.464e-05 0.0004604
149 REGULATION OF CELL SUBSTRATE ADHESION 19 173 1.482e-05 0.0004628
150 MESENCHYME DEVELOPMENT 20 190 1.673e-05 0.0005189
151 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 14 103 1.808e-05 0.0005572
152 MESONEPHROS DEVELOPMENT 13 90 1.846e-05 0.000565
153 CELL DEATH 62 1001 1.883e-05 0.0005726
154 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 8 34 2.062e-05 0.0006229
155 REGULATION OF KINASE ACTIVITY 51 776 2.299e-05 0.0006902
156 REGULATION OF CELL PROLIFERATION 84 1496 2.473e-05 0.0007375
157 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 43 616 2.511e-05 0.0007443
158 SMOOTH MUSCLE TISSUE DEVELOPMENT 6 18 2.646e-05 0.0007793
159 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 16 135 2.7e-05 0.00079
160 REGULATION OF EPITHELIAL CELL MIGRATION 18 166 2.935e-05 0.0008419
161 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 18 166 2.935e-05 0.0008419
162 ACTION POTENTIAL 13 94 2.967e-05 0.0008419
163 RESPONSE TO BMP 13 94 2.967e-05 0.0008419
164 CELLULAR RESPONSE TO BMP STIMULUS 13 94 2.967e-05 0.0008419
165 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 15 122 3.097e-05 0.0008732
166 POSITIVE REGULATION OF AXONOGENESIS 11 69 3.152e-05 0.0008834
167 OLFACTORY LOBE DEVELOPMENT 8 36 3.225e-05 0.0008987
168 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 22 232 3.322e-05 0.0009199
169 PALLIUM DEVELOPMENT 17 153 3.549e-05 0.0009772
170 KIDNEY EPITHELIUM DEVELOPMENT 15 125 4.129e-05 0.00113
171 GASTRULATION 17 155 4.193e-05 0.001141
172 POSITIVE REGULATION OF OSSIFICATION 12 84 4.304e-05 0.001164
173 CYTOSKELETON ORGANIZATION 53 838 4.461e-05 0.0012
174 REGULATION OF OSTEOBLAST DIFFERENTIATION 14 112 4.695e-05 0.001256
175 REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 10 60 4.848e-05 0.001289
176 NEURON PROJECTION GUIDANCE 20 205 5.011e-05 0.001325
177 REGULATION OF CELL PROJECTION ORGANIZATION 39 558 5.788e-05 0.001516
178 REGULATION OF JNK CASCADE 17 159 5.799e-05 0.001516
179 CARDIAC CHAMBER DEVELOPMENT 16 144 5.977e-05 0.001537
180 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 8 39 5.964e-05 0.001537
181 POSITIVE REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 8 39 5.964e-05 0.001537
182 TISSUE REMODELING 12 87 6.127e-05 0.001566
183 POSITIVE REGULATION OF KINASE ACTIVITY 35 482 6.47e-05 0.001644
184 REGULATION OF BLOOD CIRCULATION 25 295 6.502e-05 0.001644
185 DEVELOPMENTAL MATURATION 19 193 6.789e-05 0.001708
186 RESPONSE TO MECHANICAL STIMULUS 20 210 7.032e-05 0.001759
187 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 13 102 7.09e-05 0.001764
188 DEVELOPMENTAL GROWTH 27 333 7.186e-05 0.001779
189 MAINTENANCE OF CELL NUMBER 15 132 7.79e-05 0.001918
190 NEGATIVE REGULATION OF LOCOMOTION 23 263 7.836e-05 0.001919
191 GROWTH 31 410 8.035e-05 0.001957
192 MESODERM DEVELOPMENT 14 118 8.371e-05 0.002029
193 ENDOTHELIUM DEVELOPMENT 12 90 8.581e-05 0.002058
194 REGULATION OF CHEMOTAXIS 18 180 8.55e-05 0.002058
195 CARDIAC CHAMBER MORPHOGENESIS 13 104 8.686e-05 0.002073
196 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 5 14 8.868e-05 0.002105
197 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 19 197 8.946e-05 0.002113
198 REGULATION OF FAT CELL DIFFERENTIATION 13 106 0.0001058 0.002487
199 MORPHOGENESIS OF A BRANCHING STRUCTURE 17 167 0.0001071 0.002504
200 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 10 66 0.0001119 0.002551
201 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 14 121 0.0001101 0.002551
202 MESODERM MORPHOGENESIS 10 66 0.0001119 0.002551
203 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 10 66 0.0001119 0.002551
204 LENS DEVELOPMENT IN CAMERA TYPE EYE 10 66 0.0001119 0.002551
205 CELLULAR RESPONSE TO LIPID 33 457 0.0001154 0.002607
206 TRANSMISSION OF NERVE IMPULSE 9 54 0.0001153 0.002607
207 EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS 12 93 0.0001184 0.002661
208 REGULATION OF MAPK CASCADE 43 660 0.0001219 0.002726
209 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 10 67 0.0001273 0.002835
210 OLFACTORY BULB INTERNEURON DIFFERENTIATION 5 15 0.0001291 0.002847
211 VENOUS BLOOD VESSEL DEVELOPMENT 5 15 0.0001291 0.002847
212 CRANIAL SKELETAL SYSTEM DEVELOPMENT 9 55 0.0001335 0.002931
213 SINGLE ORGANISM BEHAVIOR 29 384 0.0001379 0.003012
214 CELLULAR RESPONSE TO PEPTIDE 23 274 0.000145 0.003152
215 TAXIS 33 464 0.0001533 0.003317
216 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 33 465 0.0001595 0.003436
217 REGULATION OF NEURON PROJECTION DEVELOPMENT 30 408 0.0001702 0.003635
218 STEM CELL DIFFERENTIATION 18 190 0.0001703 0.003635
219 ACTIN FILAMENT ORGANIZATION 17 174 0.0001768 0.003757
220 GLAND MORPHOGENESIS 12 97 0.0001779 0.003762
221 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 80 1492 0.000179 0.003769
222 CARDIAC MYOFIBRIL ASSEMBLY 5 16 0.0001823 0.003821
223 POSITIVE REGULATION OF MAPK CASCADE 33 470 0.0001942 0.004053
224 CELL PART MORPHOGENESIS 41 633 0.0001972 0.004096
225 REGULATION OF ION TRANSPORT 39 592 0.0001994 0.004123
226 EMBRYONIC CRANIAL SKELETON MORPHOGENESIS 8 46 0.0002028 0.004164
227 REGULATION OF STEM CELL DIFFERENTIATION 13 113 0.0002032 0.004164
228 SECOND MESSENGER MEDIATED SIGNALING 16 160 0.0002079 0.004244
229 CARDIAC SEPTUM DEVELOPMENT 11 85 0.0002197 0.004405
230 PALATE DEVELOPMENT 11 85 0.0002197 0.004405
231 CELL JUNCTION ASSEMBLY 14 129 0.0002182 0.004405
232 HEART PROCESS 11 85 0.0002197 0.004405
233 PHOSPHORYLATION 68 1228 0.0002283 0.00456
234 ENDOTHELIAL CELL DIFFERENTIATION 10 72 0.0002345 0.004662
235 EPITHELIAL CELL DIFFERENTIATION 34 495 0.0002354 0.004662
236 LIMBIC SYSTEM DEVELOPMENT 12 100 0.0002377 0.004687
237 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 45 724 0.0002458 0.004825
238 REGULATION OF MUSCLE CONTRACTION 15 147 0.0002607 0.005097
239 REGULATION OF SMOOTH MUSCLE CONTRACTION 9 60 0.0002648 0.005112
240 HIPPOCAMPUS DEVELOPMENT 10 73 0.0002631 0.005112
241 CHONDROCYTE DIFFERENTIATION 9 60 0.0002648 0.005112
242 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 36 541 0.000287 0.005495
243 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 36 541 0.000287 0.005495
244 CELL COMMUNICATION INVOLVED IN CARDIAC CONDUCTION 7 37 0.000295 0.005591
245 REGULATION OF METAL ION TRANSPORT 25 325 0.0002956 0.005591
246 CARDIAC MUSCLE CELL ACTION POTENTIAL 7 37 0.000295 0.005591
247 MEMBRANE DEPOLARIZATION 9 61 0.0003009 0.005668
248 NEGATIVE REGULATION OF PHOSPHORYLATION 30 422 0.0003034 0.005692
249 EYE DEVELOPMENT 25 326 0.0003096 0.005785
250 RESPONSE TO PEPTIDE 29 404 0.0003241 0.005992
251 MESENCHYMAL CELL DIFFERENTIATION 14 134 0.0003245 0.005992
252 REGULATION OF PROTEIN IMPORT 17 183 0.0003224 0.005992
253 REGULATION OF TRANSPORT 92 1804 0.0003272 0.006018
254 ARTERY DEVELOPMENT 10 75 0.0003292 0.006031
255 RESPONSE TO CAFFEINE 5 18 0.0003369 0.006147
256 RESPONSE TO CYTOKINE 44 714 0.0003449 0.006268
257 COLLAGEN FIBRIL ORGANIZATION 7 38 0.0003505 0.006322
258 MESENCHYME MORPHOGENESIS 7 38 0.0003505 0.006322
259 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 8 50 0.000368 0.006611
260 IN UTERO EMBRYONIC DEVELOPMENT 24 311 0.0003698 0.006619
261 REGULATION OF MUSCLE CELL DIFFERENTIATION 15 152 0.0003747 0.006679
262 REGULATION OF CARTILAGE DEVELOPMENT 9 63 0.0003854 0.006844
263 REGULATION OF HEART CONTRACTION 19 221 0.0003957 0.007001
264 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 15 153 0.000402 0.007085
265 NEGATIVE REGULATION OF CELL GROWTH 16 170 0.0004135 0.007261
266 RESPONSE TO ORGANIC CYCLIC COMPOUND 53 917 0.0004215 0.007372
267 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 13 122 0.0004334 0.007553
268 OLFACTORY BULB INTERNEURON DEVELOPMENT 4 11 0.0004395 0.007631
269 REGULATION OF ANATOMICAL STRUCTURE SIZE 32 472 0.0004458 0.007711
270 REGULATION OF CELLULAR COMPONENT BIOGENESIS 46 767 0.00046 0.007928
271 ACTIN FILAMENT BASED MOVEMENT 11 93 0.0004849 0.008325
272 CALCIUM ION IMPORT 9 65 0.0004885 0.008356
273 GLAND DEVELOPMENT 28 395 0.0004979 0.008487
274 REGULATION OF TRANSFERASE ACTIVITY 54 946 0.0005004 0.008498
275 BONE MORPHOGENESIS 10 79 0.0005034 0.008518
276 POSITIVE REGULATION OF CELL ADHESION 27 376 0.0005111 0.008617
277 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 33 498 0.0005452 0.009157
278 STEROID HORMONE MEDIATED SIGNALING PATHWAY 13 125 0.000548 0.009172
279 NEGATIVE REGULATION OF CELL SUBSTRATE ADHESION 8 53 0.0005529 0.009188
280 MESONEPHRIC TUBULE MORPHOGENESIS 8 53 0.0005529 0.009188
281 HORMONE MEDIATED SIGNALING PATHWAY 15 158 0.0005656 0.009365
282 LUNG ALVEOLUS DEVELOPMENT 7 41 0.000569 0.009389
283 RELAXATION OF MUSCLE 5 20 0.0005744 0.009444
284 REGULATION OF TRANSCRIPTION FACTOR IMPORT INTO NUCLEUS 11 95 0.0005823 0.009507
285 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 11 95 0.0005823 0.009507
NumGOOverlapSizeP ValueAdj. P Value
1 REGULATORY REGION NUCLEIC ACID BINDING 67 818 2.294e-10 2.131e-07
2 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 85 1199 1.11e-09 5.157e-07
3 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 52 629 1.934e-08 3.593e-06
4 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 33 303 1.452e-08 3.593e-06
5 MOLECULAR FUNCTION REGULATOR 89 1353 1.636e-08 3.593e-06
6 E BOX BINDING 10 34 1.954e-07 3.025e-05
7 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 32 328 3.092e-07 4.104e-05
8 RHO GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 14 77 5.205e-07 6.045e-05
9 TRANSCRIPTION FACTOR BINDING 42 524 1.041e-06 0.0001075
10 SMAD BINDING 13 72 1.439e-06 0.0001337
11 DOUBLE STRANDED DNA BINDING 54 764 1.593e-06 0.0001345
12 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 24 228 2.468e-06 0.000191
13 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 29 315 3.536e-06 0.0002361
14 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 44 588 3.557e-06 0.0002361
15 BHLH TRANSCRIPTION FACTOR BINDING 8 28 4.269e-06 0.0002644
16 CALMODULIN BINDING 20 179 6.861e-06 0.0003984
17 BETA CATENIN BINDING 13 84 8.558e-06 0.0004677
18 TRANSFORMING GROWTH FACTOR BETA BINDING 6 16 1.214e-05 0.0005935
19 ENZYME BINDING 96 1737 1.163e-05 0.0005935
20 KINASE ACTIVITY 55 842 1.304e-05 0.0006034
21 RECEPTOR SIGNALING PROTEIN ACTIVITY 19 172 1.364e-05 0.0006034
22 BINDING BRIDGING 19 173 1.482e-05 0.0006258
23 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 14 104 2.022e-05 0.0008166
24 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 22 226 2.218e-05 0.0008586
25 ACTIVATING TRANSCRIPTION FACTOR BINDING 10 57 3.059e-05 0.001093
26 PROTEIN SERINE THREONINE KINASE ACTIVITY 34 445 2.983e-05 0.001093
27 ACTIN BINDING 31 393 3.643e-05 0.001253
28 CELL ADHESION MOLECULE BINDING 19 186 4.1e-05 0.00136
29 SEQUENCE SPECIFIC DNA BINDING 62 1037 5.327e-05 0.001707
30 PROTEIN KINASE ACTIVITY 43 640 6.106e-05 0.001891
31 ZINC ION BINDING 67 1155 6.633e-05 0.001988
32 CORE PROMOTER PROXIMAL REGION DNA BINDING 29 371 7.566e-05 0.002197
33 PROTEIN DIMERIZATION ACTIVITY 66 1149 0.0001004 0.002825
34 GROWTH FACTOR BINDING 14 123 0.0001314 0.00359
35 NUCLEOSIDE TRIPHOSPHATASE REGULATOR ACTIVITY 26 329 0.0001471 0.003904
36 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 58 992 0.0001684 0.004346
37 CYTOSKELETAL ADAPTOR ACTIVITY 5 16 0.0001823 0.004577
38 PROTEIN HOMODIMERIZATION ACTIVITY 45 722 0.0002313 0.005396
39 STEROID HORMONE RECEPTOR ACTIVITY 9 59 0.0002323 0.005396
40 ENZYME REGULATOR ACTIVITY 56 959 0.000225 0.005396
41 RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING 7 36 0.0002467 0.00559
42 TRANSCRIPTION FACTOR ACTIVITY DIRECT LIGAND REGULATED SEQUENCE SPECIFIC DNA BINDING 8 48 0.0002754 0.006093
43 CYTOSKELETAL PROTEIN BINDING 49 819 0.0003198 0.006753
44 KINASE BINDING 39 606 0.0003186 0.006753
45 CALCIUM ION BINDING 43 697 0.0003923 0.007992
46 TRANSCRIPTION COREPRESSOR ACTIVITY 19 221 0.0003957 0.007992
47 CYTOKINE BINDING 11 92 0.0004415 0.008371
48 RECEPTOR SIGNALING PROTEIN SERINE THREONINE KINASE ACTIVITY 11 92 0.0004415 0.008371
49 PLATELET DERIVED GROWTH FACTOR BINDING 4 11 0.0004395 0.008371
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 82 1151 1.796e-09 1.049e-06
2 ANCHORING JUNCTION 45 489 7.514e-09 2.194e-06
3 CYTOSKELETON 113 1967 2.533e-07 4.932e-05
4 CELL SUBSTRATE JUNCTION 36 398 3.688e-07 5.385e-05
5 MEMBRANE REGION 73 1134 8.119e-07 9.483e-05
6 CELL CELL CONTACT ZONE 12 64 2.405e-06 0.000216
7 NEURON PART 77 1265 3.324e-06 0.000216
8 NEURON PROJECTION 62 942 2.834e-06 0.000216
9 T TUBULE 10 45 3.329e-06 0.000216
10 MEMBRANE MICRODOMAIN 27 288 5.447e-06 0.0003181
11 NODE OF RANVIER 6 15 7.823e-06 0.0004153
12 CELL CELL JUNCTION 32 383 8.661e-06 0.0004215
13 INTRINSIC COMPONENT OF PLASMA MEMBRANE 92 1649 1.255e-05 0.0005636
14 POSTSYNAPSE 31 378 1.721e-05 0.0007179
15 CORTICAL CYTOSKELETON 12 81 2.971e-05 0.001084
16 PLASMA MEMBRANE REGION 58 929 2.814e-05 0.001084
17 CORTICAL ACTIN CYTOSKELETON 10 58 3.579e-05 0.0011
18 MAIN AXON 10 58 3.579e-05 0.0011
19 CELL PROJECTION 96 1786 3.481e-05 0.0011
20 SARCOLEMMA 15 125 4.129e-05 0.001206
21 SYNAPSE 49 754 4.419e-05 0.001229
22 PLASMA MEMBRANE RAFT 12 86 5.457e-05 0.001449
23 ACTIN CYTOSKELETON 33 444 6.664e-05 0.001622
24 ACTOMYOSIN 10 62 6.483e-05 0.001622
25 EXTRACELLULAR MATRIX 32 426 7.011e-05 0.00163
26 BASAL PART OF CELL 9 51 7.258e-05 0.00163
27 CELL CORTEX PART 14 119 9.181e-05 0.001915
28 PROTEINACEOUS EXTRACELLULAR MATRIX 28 356 9.004e-05 0.001915
29 I BAND 14 121 0.0001101 0.002217
30 AXON 31 418 0.0001143 0.002224
31 CONTRACTILE FIBER 19 211 0.0002201 0.004146
32 CELL SURFACE 46 757 0.0003464 0.006321
33 CELL LEADING EDGE 26 350 0.0003868 0.006844
34 NEURON SPINE 13 121 4e-04 0.006871
35 INTERCALATED DISC 8 51 0.000423 0.007057
36 VACUOLE 64 1180 0.0006024 0.009507
37 PROTEIN COMPLEX INVOLVED IN CELL ADHESION 6 30 0.0005866 0.009507
38 PARANODE REGION OF AXON 4 12 0.0006407 0.009594
39 BANDED COLLAGEN FIBRIL 4 12 0.0006407 0.009594
40 APICAL JUNCTION COMPLEX 13 128 0.0006872 0.009997
41 SYNAPSE PART 38 610 0.0007018 0.009997

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Focal_adhesion_hsa04510 20 199 3.28e-05 0.001458
2 FoxO_signaling_pathway_hsa04068 15 132 7.79e-05 0.001458
3 Calcium_signaling_pathway_hsa04020 18 182 9.859e-05 0.001458
4 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 15 139 0.0001402 0.001458
5 MAPK_signaling_pathway_hsa04010 24 295 0.0001691 0.001458
6 Regulation_of_actin_cytoskeleton_hsa04810 19 208 0.000183 0.001458
7 TGF_beta_signaling_pathway_hsa04350 11 84 0.0001975 0.001458
8 Cell_adhesion_molecules_.CAMs._hsa04514 15 145 0.0002243 0.001458
9 Apelin_signaling_pathway_hsa04371 14 137 0.0004075 0.001936
10 Hippo_signaling_pathway_hsa04390 15 154 0.000431 0.001936
11 Hippo_signaling_pathway_multiple_species_hsa04392 6 29 0.0004838 0.001936
12 TNF_signaling_pathway_hsa04668 12 108 0.0004869 0.001936
13 Oocyte_meiosis_hsa04114 13 124 0.0005072 0.001936
14 Endocytosis_hsa04144 20 244 0.0005213 0.001936
15 ECM_receptor_interaction_hsa04512 10 82 0.0006792 0.002355
16 cGMP_PKG_signaling_pathway_hsa04022 15 163 0.0007828 0.002544
17 mTOR_signaling_pathway_hsa04150 14 151 0.001076 0.00329
18 Gap_junction_hsa04540 10 88 0.001183 0.003418
19 cAMP_signaling_pathway_hsa04024 16 198 0.002101 0.005751
20 Wnt_signaling_pathway_hsa04310 13 146 0.002296 0.00597
21 Tight_junction_hsa04530 14 170 0.003272 0.008101
22 Phospholipase_D_signaling_pathway_hsa04072 12 146 0.006316 0.01493
23 Rap1_signaling_pathway_hsa04015 15 206 0.007439 0.01682
24 PI3K_Akt_signaling_pathway_hsa04151 22 352 0.008422 0.01825
25 ErbB_signaling_pathway_hsa04012 8 85 0.01109 0.02306
26 Ras_signaling_pathway_hsa04014 15 232 0.02026 0.04052
27 Sphingolipid_signaling_pathway_hsa04071 9 118 0.02594 0.04967
28 Apoptosis_hsa04210 10 138 0.02674 0.04967
29 Adherens_junction_hsa04520 6 72 0.04393 0.07878
30 Ferroptosis_hsa04216 4 40 0.05386 0.09336
31 Cellular_senescence_hsa04218 10 160 0.06217 0.1043
32 Jak_STAT_signaling_pathway_hsa04630 10 162 0.06642 0.1064
33 HIF_1_signaling_pathway_hsa04066 7 100 0.06755 0.1064
34 Autophagy_animal_hsa04140 8 128 0.08905 0.1362
35 Phagosome_hsa04145 9 152 0.09608 0.1389
36 p53_signaling_pathway_hsa04115 5 68 0.0962 0.1389
37 Cytokine_cytokine_receptor_interaction_hsa04060 14 270 0.1069 0.1503
38 Necroptosis_hsa04217 9 164 0.135 0.1848
39 Phosphatidylinositol_signaling_system_hsa04070 6 99 0.1442 0.1922
40 VEGF_signaling_pathway_hsa04370 4 59 0.1603 0.2084
41 Peroxisome_hsa04146 5 83 0.1764 0.2237
42 NF_kappa_B_signaling_pathway_hsa04064 5 95 0.2536 0.314
43 AMPK_signaling_pathway_hsa04152 6 121 0.2662 0.3219
44 Apoptosis_multiple_species_hsa04215 2 33 0.3319 0.3922
45 ABC_transporters_hsa02010 2 45 0.4824 0.5575
46 Notch_signaling_pathway_hsa04330 2 48 0.5167 0.5841
47 Neuroactive_ligand_receptor_interaction_hsa04080 10 278 0.5391 0.5965
48 Lysosome_hsa04142 4 123 0.6464 0.6926
49 Cell_cycle_hsa04110 4 124 0.6526 0.6926
50 Mitophagy_animal_hsa04137 2 65 0.6813 0.7085

Quest ID: 5912ea021097f649142fc44cbf9a3a5a