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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-141-3p ACADSB -0.35 0.257 -2.11 0 MirTarget -0.11 0.00127 NA
2 hsa-miR-141-3p ACO1 -0.35 0.257 -0.9 0 MirTarget; TargetScan -0.12 0 NA
3 hsa-miR-141-3p ADRB1 -0.35 0.257 -2.23 0 TargetScan -0.15 0.0028 NA
4 hsa-miR-141-3p APOH -0.35 0.257 -1.63 0 TargetScan -0.21 6.0E-5 NA
5 hsa-miR-141-3p APOLD1 -0.35 0.257 0.45 0.00929 TargetScan -0.14 0 NA
6 hsa-miR-141-3p AR -0.35 0.257 -2.66 0 mirMAP -0.41 0 26062412; 22314666 miR 141 3p regulates the expression of androgen receptor by targeting its 3'UTR in prostate cancer LNCaP cells; After prostate cancer cell line LNCaP was transfected with miR-141-3p mimics expression levels of AR mRNA and protein in the LNCaP cells were detected by reverse transcription PCR and Western blotting respectively; The 3'untranslated regions 3'UTR of AR mRNA containing the binding site of miR-141-3p was amplified by PCR and inserted into pmiR-report vector a 3'downstream luciferase reporter gene; Transfection of miR-141-3p mimics decreased both mRNA and protein expression levels of AR in LNCaP cells; AR is a direct target gene of miR-141-3p;miR 141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein; Here we investigated the correlation of Shp expression with the cellular level of miR-141 and its effects on AR transcriptional activity in non-malignant and malignant human prostate epithelial cell lines; Phenethyl isothiocyanate a natural constituent of many edible cruciferous vegetables increased Shp expression downregulated miR-141 and inhibited AR transcriptional activity in LNCaP cells; Shp is a target for miR-141 and it is downregulated in cultured human PCa cells with the involvement of upregulation of miR-141 which promotes AR transcriptional activity
7 hsa-miR-141-3p ATXN7L1 -0.35 0.257 -0.24 0.06065 TargetScan; miRNATAP -0.11 0 NA
8 hsa-miR-141-3p C1orf21 -0.35 0.257 -0.75 0.00045 TargetScan; miRNATAP -0.14 3.0E-5 NA
9 hsa-miR-141-3p CADM1 -0.35 0.257 -0.03 0.88629 MirTarget; TargetScan -0.18 0 NA
10 hsa-miR-141-3p CDC14B -0.35 0.257 -1.19 0 mirMAP -0.2 0 NA
11 hsa-miR-141-3p CDK6 -0.35 0.257 -0.31 0.22057 TargetScan; miRNATAP -0.14 0.00031 NA
12 hsa-miR-141-3p CELF6 -0.35 0.257 1.59 0 TargetScan -0.14 0.00018 NA
13 hsa-miR-141-3p CFL2 -0.35 0.257 -1.18 0 TargetScan -0.15 0 NA
14 hsa-miR-141-3p CLYBL -0.35 0.257 -1.25 0 mirMAP -0.17 0 NA
15 hsa-miR-141-3p CPEB3 -0.35 0.257 -2.74 0 MirTarget -0.13 0.00026 NA
16 hsa-miR-141-3p CPLX2 -0.35 0.257 5.16 0 mirMAP -0.47 8.0E-5 NA
17 hsa-miR-141-3p DDI2 -0.35 0.257 -1.53 0 mirMAP -0.13 0.0105 NA
18 hsa-miR-141-3p DYNC1I1 -0.35 0.257 1.67 1.0E-5 MirTarget -0.18 0.00244 NA
19 hsa-miR-141-3p ELL2 -0.35 0.257 -0.77 0 TargetScan -0.13 0 NA
20 hsa-miR-141-3p FAM169A -0.35 0.257 0.37 0.13291 mirMAP -0.12 0.00113 NA
21 hsa-miR-141-3p FKBP5 -0.35 0.257 -0.23 0.1942 TargetScan -0.12 2.0E-5 NA
22 hsa-miR-141-3p GFRA1 -0.35 0.257 -2.55 0 mirMAP -0.26 0.00043 NA
23 hsa-miR-141-3p GFRA2 -0.35 0.257 -1.04 0 mirMAP -0.17 0 NA
24 hsa-miR-141-3p GLRX -0.35 0.257 -0.98 0 MirTarget; TargetScan; miRNATAP -0.11 3.0E-5 NA
25 hsa-miR-141-3p GNE -0.35 0.257 -1.82 0 MirTarget -0.16 0 NA
26 hsa-miR-141-3p GNG7 -0.35 0.257 -0.34 0.08092 MirTarget; TargetScan; miRNATAP -0.14 0 NA
27 hsa-miR-141-3p GNPTG -0.35 0.257 0.04 0.71843 TargetScan -0.11 0 NA
28 hsa-miR-141-3p GPAM -0.35 0.257 -0.47 0.0638 MirTarget -0.1 0.00991 NA
29 hsa-miR-141-3p GPD1 -0.35 0.257 -2.61 0 TargetScan -0.17 0.00103 NA
30 hsa-miR-141-3p GPHN -0.35 0.257 -1.46 0 TargetScan; miRNATAP -0.16 0 NA
31 hsa-miR-141-3p HLF -0.35 0.257 -1.56 0 TargetScan -0.31 0 NA
32 hsa-miR-141-3p HNMT -0.35 0.257 -0.67 0 TargetScan -0.11 0 NA
33 hsa-miR-141-3p HOMER2 -0.35 0.257 -1.01 6.0E-5 mirMAP -0.12 0.00188 NA
34 hsa-miR-141-3p HS3ST3B1 -0.35 0.257 -2.61 0 mirMAP -0.16 0.00159 NA
35 hsa-miR-141-3p IL6R -0.35 0.257 -0.2 0.38255 MirTarget -0.14 5.0E-5 NA
36 hsa-miR-141-3p IRS2 -0.35 0.257 -0.81 1.0E-5 MirTarget; TargetScan; miRNATAP -0.16 0 27186273 Forced expression of IRS2 reversed the inhibition effect induced by miR-141 overexpression in thyroid cancer cells; Taken together our study provides the first evidence that miR-141 suppressed thyroid cancer cell growth and metastasis through inhibition of IRS2
37 hsa-miR-141-3p IYD -0.35 0.257 -2.66 0 mirMAP -0.16 0.00599 NA
38 hsa-miR-141-3p KLF12 -0.35 0.257 -0.86 0 MirTarget; TargetScan -0.13 0 NA
39 hsa-miR-141-3p KLHDC10 -0.35 0.257 -0.3 0.0707 TargetScan -0.14 0 NA
40 hsa-miR-141-3p MFAP3L -0.35 0.257 -3 0 MirTarget -0.17 0.00223 NA
41 hsa-miR-141-3p MOCS2 -0.35 0.257 -0.17 0.11041 TargetScan -0.13 0 NA
42 hsa-miR-141-3p MTSS1 -0.35 0.257 -0.16 0.21015 TargetScan; miRNATAP -0.11 0 NA
43 hsa-miR-141-3p MYRIP -0.35 0.257 -1.63 2.0E-5 MirTarget; TargetScan -0.49 0 NA
44 hsa-miR-141-3p NFIA -0.35 0.257 -0.92 0 TargetScan; miRNATAP -0.13 0 NA
45 hsa-miR-141-3p NUDT12 -0.35 0.257 -0.91 2.0E-5 MirTarget -0.19 0 NA
46 hsa-miR-141-3p NUDT16 -0.35 0.257 -0.31 0.00173 mirMAP -0.12 0 NA
47 hsa-miR-141-3p PDXP -0.35 0.257 -0.39 0.00374 TargetScan -0.12 0 NA
48 hsa-miR-141-3p PGRMC1 -0.35 0.257 -0.9 0 TargetScan -0.16 0 NA
49 hsa-miR-141-3p PHLPP1 -0.35 0.257 -0.74 0 MirTarget; TargetScan; miRNATAP -0.12 0 24945731 MicroRNA 141 promotes the proliferation of non small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2; Together the results of this study suggest that miR-141 and its targets PHLPP1 and PHLPP2 play critical roles in NSCLC tumorigenesis and provide potential therapeutic targets for NSCLC treatment
50 hsa-miR-141-3p PHYHIPL -0.35 0.257 0.88 0.00299 MirTarget; TargetScan; miRNATAP -0.11 0.01435 NA
51 hsa-miR-141-3p PPARA -0.35 0.257 -0.61 3.0E-5 miRNAWalker2 validate; miRTarBase -0.12 0 NA
52 hsa-miR-141-3p PPP1R3G -0.35 0.257 -0.77 0.03361 TargetScan -0.2 0.00048 NA
53 hsa-miR-141-3p RAD54L2 -0.35 0.257 -0.97 1.0E-5 TargetScan -0.1 0.00219 NA
54 hsa-miR-141-3p RBM24 -0.35 0.257 1.89 0 TargetScan -0.23 0 NA
55 hsa-miR-141-3p RNF217 -0.35 0.257 -0.87 3.0E-5 mirMAP -0.11 0.00076 NA
56 hsa-miR-141-3p RORA -0.35 0.257 -1.19 0 MirTarget; TargetScan; miRNATAP -0.12 3.0E-5 NA
57 hsa-miR-141-3p RSPO2 -0.35 0.257 -1.48 0.00047 MirTarget -0.27 4.0E-5 NA
58 hsa-miR-141-3p SCP2 -0.35 0.257 -1.7 0 miRNATAP -0.15 0 NA
59 hsa-miR-141-3p SDC2 -0.35 0.257 -0.03 0.81477 MirTarget; TargetScan -0.11 0 NA
60 hsa-miR-141-3p SERPINC1 -0.35 0.257 -1.64 4.0E-5 TargetScan -0.34 0 NA
61 hsa-miR-141-3p SFXN1 -0.35 0.257 -0.99 0 TargetScan -0.12 0 NA
62 hsa-miR-141-3p SLC16A7 -0.35 0.257 -1.26 2.0E-5 MirTarget; TargetScan; miRNATAP -0.1 0.0259 NA
63 hsa-miR-141-3p SLC1A1 -0.35 0.257 -2.49 0 TargetScan; miRNATAP -0.12 0.03924 NA
64 hsa-miR-141-3p SLC23A2 -0.35 0.257 -0.58 0.00102 TargetScan; miRNATAP -0.14 0 NA
65 hsa-miR-141-3p SLC25A42 -0.35 0.257 -0.84 0 mirMAP -0.13 0 NA
66 hsa-miR-141-3p SLC30A1 -0.35 0.257 -1.21 0 TargetScan -0.11 6.0E-5 NA
67 hsa-miR-141-3p SORBS2 -0.35 0.257 -1.05 0 MirTarget; TargetScan -0.13 1.0E-5 NA
68 hsa-miR-141-3p SPPL2A -0.35 0.257 -0.16 0.10882 TargetScan -0.1 0 NA
69 hsa-miR-141-3p SSTR1 -0.35 0.257 -1.62 1.0E-5 mirMAP -0.27 0 NA
70 hsa-miR-141-3p ST3GAL3 -0.35 0.257 0.05 0.68974 MirTarget; TargetScan; miRNATAP -0.14 0 NA
71 hsa-miR-141-3p TAPT1 -0.35 0.257 -1.13 0 TargetScan -0.11 0 NA
72 hsa-miR-141-3p THRB -0.35 0.257 -0.63 0 MirTarget; TargetScan; miRNATAP -0.1 0 NA
73 hsa-miR-141-3p TMEM192 -0.35 0.257 -1.03 0 TargetScan -0.12 0 NA
74 hsa-miR-141-3p TMEM56 -0.35 0.257 -1.76 0 MirTarget; TargetScan; miRNATAP -0.15 0 NA
75 hsa-miR-141-3p TTR -0.35 0.257 -2.49 0 MirTarget; TargetScan; miRNATAP -0.2 0.00066 NA
76 hsa-miR-141-3p UGT1A1 -0.35 0.257 -2.58 0 TargetScan -0.31 0 NA
77 hsa-miR-141-3p UGT1A3 -0.35 0.257 -2.58 0 MirTarget; TargetScan -0.46 0 NA
78 hsa-miR-141-3p UGT1A4 -0.35 0.257 -3.36 0 MirTarget; TargetScan -0.56 0 NA
79 hsa-miR-141-3p UGT1A5 -0.35 0.257 -2.24 0 MirTarget; TargetScan -0.4 0 NA
80 hsa-miR-141-3p UGT1A6 -0.35 0.257 -1.16 0.00102 MirTarget; TargetScan -0.17 0.0025 NA
81 hsa-miR-141-3p UGT1A9 -0.35 0.257 -1.35 0.00014 MirTarget; TargetScan -0.28 0 NA
82 hsa-miR-141-3p USH2A -0.35 0.257 -2.27 0 MirTarget -0.15 0.00466 NA
83 hsa-miR-141-3p WNK3 -0.35 0.257 -0.84 0.00786 mirMAP -0.18 0.00024 NA
84 hsa-miR-141-3p ZBTB16 -0.35 0.257 -1.17 0.0001 TargetScan -0.28 0 NA
85 hsa-miR-141-3p ZCCHC24 -0.35 0.257 -1.09 0 MirTarget; TargetScan; miRNATAP -0.12 0 NA
86 hsa-miR-141-3p ZFAND5 -0.35 0.257 -0.9 0 TargetScan -0.11 3.0E-5 NA
87 hsa-miR-141-3p ZNF385D -0.35 0.257 1.93 1.0E-5 MirTarget; TargetScan -0.28 3.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELLULAR GLUCURONIDATION 6 22 4.012e-10 1.867e-06
2 GLUCURONATE METABOLIC PROCESS 6 27 1.564e-09 2.308e-06
3 URONIC ACID METABOLIC PROCESS 6 27 1.564e-09 2.308e-06
4 FLAVONOID METABOLIC PROCESS 6 28 1.984e-09 2.308e-06
5 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 10 172 3.848e-09 3.581e-06
6 REGULATION OF LIPID METABOLIC PROCESS 11 282 3.909e-08 3.031e-05
7 SMALL MOLECULE METABOLIC PROCESS 25 1767 7.461e-08 4.959e-05
8 REGULATION OF FATTY ACID METABOLIC PROCESS 7 87 1.017e-07 5.731e-05
9 NEGATIVE REGULATION OF CARBOHYDRATE METABOLIC PROCESS 6 53 1.108e-07 5.731e-05
10 NEGATIVE REGULATION OF FATTY ACID METABOLIC PROCESS 5 29 1.517e-07 7.056e-05
11 MONOSACCHARIDE METABOLIC PROCESS 9 202 2.378e-07 0.0001006
12 RESPONSE TO XENOBIOTIC STIMULUS 7 105 3.718e-07 0.0001442
13 DRUG METABOLIC PROCESS 5 39 7.106e-07 0.0002543
14 COFACTOR CATABOLIC PROCESS 4 20 1.534e-06 0.00051
15 ORGANIC ACID METABOLIC PROCESS 16 953 3.056e-06 0.0009479
16 REGULATION OF CELLULAR KETONE METABOLIC PROCESS 7 173 1.048e-05 0.003047
17 NEGATIVE REGULATION OF LIPID METABOLIC PROCESS 5 80 2.579e-05 0.00706
18 CARBOHYDRATE METABOLIC PROCESS 12 662 2.87e-05 0.007418
NumGOOverlapSizeP ValueAdj. P Value
1 GLUCURONOSYLTRANSFERASE ACTIVITY 6 34 6.937e-09 6.444e-06
2 RETINOIC ACID BINDING 5 23 4.386e-08 2.037e-05
3 PROTEIN HOMODIMERIZATION ACTIVITY 15 722 4.686e-07 0.0001088
4 MONOCARBOXYLIC ACID BINDING 6 65 3.825e-07 0.0001088
5 ISOPRENOID BINDING 5 40 8.093e-07 0.0001504
6 PROTEIN DIMERIZATION ACTIVITY 18 1149 1.789e-06 0.000277
7 IDENTICAL PROTEIN BINDING 18 1209 3.667e-06 0.0004867
8 LIPID BINDING 12 657 2.665e-05 0.003094
9 ORGANIC ACID BINDING 7 209 3.545e-05 0.003293
10 UDP GLYCOSYLTRANSFERASE ACTIVITY 6 139 3.217e-05 0.003293
11 STEROID BINDING 5 91 4.806e-05 0.004059
12 TRANSCRIPTION FACTOR ACTIVITY DIRECT LIGAND REGULATED SEQUENCE SPECIFIC DNA BINDING 4 48 5.616e-05 0.004347
13 STEROID HORMONE RECEPTOR ACTIVITY 4 59 0.0001267 0.009051
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Peroxisome_hsa04146 2 83 0.05074 0.8541
2 cAMP_signaling_pathway_hsa04024 3 198 0.05536 0.8541
3 PI3K_Akt_signaling_pathway_hsa04151 4 352 0.06751 0.8541
4 Cell_cycle_hsa04110 2 124 0.1016 0.8541
5 Oocyte_meiosis_hsa04114 2 124 0.1016 0.8541
6 FoxO_signaling_pathway_hsa04068 2 132 0.1127 0.8541
7 Neuroactive_ligand_receptor_interaction_hsa04080 3 278 0.1209 0.8541
8 Cell_adhesion_molecules_.CAMs._hsa04514 2 145 0.1314 0.8541
9 cGMP_PKG_signaling_pathway_hsa04022 2 163 0.1583 0.9147

Quest ID: 59be48403afc9a2d21f2e07d39874227