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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-27b-3p ABCA1 -0.44 0.00052 0.61 0.0002 MirTarget; miRNATAP -0.2 0.01239 NA
2 hsa-miR-27b-3p ADCY3 -0.44 0.00052 0.94 0 miRNATAP -0.14 0.01566 NA
3 hsa-miR-27b-3p ADD3 -0.44 0.00052 0.26 0.08127 miRNATAP -0.28 8.0E-5 NA
4 hsa-miR-27b-3p AFF2 -0.44 0.00052 0.46 0.15245 mirMAP -0.41 0.00977 NA
5 hsa-miR-27b-3p AFF4 -0.44 0.00052 -0.27 0.01565 MirTarget; miRNATAP -0.12 0.02921 NA
6 hsa-miR-27b-3p AGGF1 -0.44 0.00052 0.11 0.14733 miRNATAP -0.13 0.00026 NA
7 hsa-miR-27b-3p AGPS -0.44 0.00052 0.46 0 miRNATAP -0.14 0.00158 NA
8 hsa-miR-27b-3p ANKIB1 -0.44 0.00052 0.55 1.0E-5 miRNATAP -0.24 6.0E-5 NA
9 hsa-miR-27b-3p APAF1 -0.44 0.00052 0.59 0 miRNATAP -0.27 0 NA
10 hsa-miR-27b-3p APC -0.44 0.00052 -0.26 0.04051 miRNATAP -0.19 0.00158 22018270 Finally the APC gene was identified as the direct and functional target of miR-27
11 hsa-miR-27b-3p ARHGEF6 -0.44 0.00052 -0.62 0.00125 MirTarget -0.23 0.01706 NA
12 hsa-miR-27b-3p ARID2 -0.44 0.00052 0.23 0.02697 MirTarget; miRNATAP -0.13 0.00992 NA
13 hsa-miR-27b-3p ATAD2B -0.44 0.00052 0.36 0.00038 miRNATAP -0.11 0.03236 NA
14 hsa-miR-27b-3p ATP10B -0.44 0.00052 0.91 0.05803 miRNATAP -0.47 0.04838 NA
15 hsa-miR-27b-3p ATP11C -0.44 0.00052 0.34 0.00837 MirTarget; miRNATAP -0.19 0.00298 NA
16 hsa-miR-27b-3p ATP13A3 -0.44 0.00052 0.93 0 miRNATAP -0.24 0.00026 NA
17 hsa-miR-27b-3p ATP2A2 -0.44 0.00052 0.6 0 mirMAP -0.12 0.01032 NA
18 hsa-miR-27b-3p ATP6V1A -0.44 0.00052 0.34 0.00052 MirTarget -0.18 0.00013 NA
19 hsa-miR-27b-3p ATRX -0.44 0.00052 0.26 0.04408 miRNATAP -0.16 0.01068 NA
20 hsa-miR-27b-3p BBC3 -0.44 0.00052 1.36 0 miRNATAP -0.31 0.00055 NA
21 hsa-miR-27b-3p BEND3 -0.44 0.00052 0.62 6.0E-5 miRNATAP -0.24 0.00174 NA
22 hsa-miR-27b-3p BRPF3 -0.44 0.00052 0.01 0.87968 MirTarget; miRNATAP -0.12 0.01102 NA
23 hsa-miR-27b-3p CABLES2 -0.44 0.00052 0.48 0.00207 miRNATAP -0.17 0.02515 NA
24 hsa-miR-27b-3p CBFB -0.44 0.00052 1.06 0 MirTarget; miRNATAP -0.2 0.00163 NA
25 hsa-miR-27b-3p CCNG1 -0.44 0.00052 -0.7 0 MirTarget; miRNATAP -0.18 0.01133 26623719 Moreover miR-27b directly targets the 3' untranslated regions 3'-UTRs of CCNG1 a well-known negative regulator of P53 stability; Interestingly miR-27b up-regulation leads to increased miR-508-5p expression and this phenomenon is mediated by CCNG1 and P53
26 hsa-miR-27b-3p CCNJ -0.44 0.00052 0.91 0 MirTarget; miRNATAP -0.15 0.01943 NA
27 hsa-miR-27b-3p CCNT1 -0.44 0.00052 0.26 0.00381 miRNAWalker2 validate; miRTarBase; miRNATAP -0.13 0.00256 NA
28 hsa-miR-27b-3p CCNT2 -0.44 0.00052 0.2 0.03353 MirTarget -0.17 0.00015 NA
29 hsa-miR-27b-3p CD28 -0.44 0.00052 0.25 0.32358 miRNATAP -0.31 0.01324 NA
30 hsa-miR-27b-3p CD44 -0.44 0.00052 0.22 0.30295 miRNATAP -0.22 0.04123 NA
31 hsa-miR-27b-3p CD84 -0.44 0.00052 0.93 4.0E-5 mirMAP -0.58 0 NA
32 hsa-miR-27b-3p CDH24 -0.44 0.00052 1.11 0 miRNATAP -0.19 0.01053 NA
33 hsa-miR-27b-3p CDK6 -0.44 0.00052 0.99 0 mirMAP -0.25 0.01294 NA
34 hsa-miR-27b-3p CEP128 -0.44 0.00052 0.17 0.1262 MirTarget -0.16 0.00416 NA
35 hsa-miR-27b-3p CEP135 -0.44 0.00052 0.8 0 MirTarget -0.22 0.00011 NA
36 hsa-miR-27b-3p CEP192 -0.44 0.00052 0.5 2.0E-5 miRNAWalker2 validate -0.22 0.00012 NA
37 hsa-miR-27b-3p CIT -0.44 0.00052 1.13 0 miRNATAP -0.25 0.00069 NA
38 hsa-miR-27b-3p CLCN5 -0.44 0.00052 1.08 0 miRNATAP -0.19 0.02715 NA
39 hsa-miR-27b-3p CREB1 -0.44 0.00052 0.2 0.00537 MirTarget -0.12 0.00082 NA
40 hsa-miR-27b-3p CSF1 -0.44 0.00052 0.05 0.7202 MirTarget; miRNATAP -0.18 0.0093 NA
41 hsa-miR-27b-3p CSNK1G1 -0.44 0.00052 0.44 0 MirTarget -0.1 0.02141 NA
42 hsa-miR-27b-3p CUL4B -0.44 0.00052 0.16 0.10357 miRNAWalker2 validate -0.11 0.01958 NA
43 hsa-miR-27b-3p DCP2 -0.44 0.00052 0.5 0 miRNATAP -0.27 0 NA
44 hsa-miR-27b-3p DEPDC1B -0.44 0.00052 2.16 0 MirTarget -0.43 0.00052 NA
45 hsa-miR-27b-3p DIAPH1 -0.44 0.00052 0.27 0.0326 miRNAWalker2 validate -0.13 0.03164 NA
46 hsa-miR-27b-3p DLL4 -0.44 0.00052 1.08 0 miRNATAP -0.21 0.00942 NA
47 hsa-miR-27b-3p DMXL2 -0.44 0.00052 0.32 0.01679 miRNATAP -0.3 0 NA
48 hsa-miR-27b-3p DNAJC13 -0.44 0.00052 0.15 0.1156 MirTarget; miRNATAP -0.18 6.0E-5 NA
49 hsa-miR-27b-3p DNAJC5B -0.44 0.00052 1.85 0 miRNATAP -0.77 0 NA
50 hsa-miR-27b-3p E2F6 -0.44 0.00052 0.5 0 miRNATAP -0.15 0.00028 NA
51 hsa-miR-27b-3p E2F7 -0.44 0.00052 2.74 0 miRNATAP -0.48 0.00229 NA
52 hsa-miR-27b-3p EBF2 -0.44 0.00052 1.63 0 miRNATAP -0.37 0.03217 NA
53 hsa-miR-27b-3p EIF2AK2 -0.44 0.00052 0.64 0 mirMAP -0.24 2.0E-5 NA
54 hsa-miR-27b-3p ENC1 -0.44 0.00052 1.98 0 miRNATAP -0.51 0 NA
55 hsa-miR-27b-3p EPB41 -0.44 0.00052 0.2 0.08107 MirTarget; miRNATAP -0.11 0.04596 NA
56 hsa-miR-27b-3p EXOC8 -0.44 0.00052 0.22 0.00598 MirTarget -0.13 0.00095 NA
57 hsa-miR-27b-3p FAM120C -0.44 0.00052 0.17 0.2632 mirMAP; miRNATAP -0.15 0.03938 NA
58 hsa-miR-27b-3p FAM133B -0.44 0.00052 0.46 0.00094 MirTarget; miRNATAP -0.17 0.01051 NA
59 hsa-miR-27b-3p FAM193B -0.44 0.00052 0.06 0.53304 miRNATAP -0.1 0.0273 NA
60 hsa-miR-27b-3p FAM69A -0.44 0.00052 -0.66 0 miRNATAP -0.15 0.01462 NA
61 hsa-miR-27b-3p FAM78A -0.44 0.00052 0.46 0.01926 MirTarget; miRNATAP -0.3 0.00182 NA
62 hsa-miR-27b-3p FBXO34 -0.44 0.00052 -0.08 0.43381 miRNATAP -0.1 0.04924 NA
63 hsa-miR-27b-3p FGD6 -0.44 0.00052 1.06 0 MirTarget; miRNATAP -0.37 1.0E-5 NA
64 hsa-miR-27b-3p FN1 -0.44 0.00052 1.64 0 MirTarget -0.35 0.02293 NA
65 hsa-miR-27b-3p FOXD2 -0.44 0.00052 2.37 0 miRNATAP -0.66 0 NA
66 hsa-miR-27b-3p FOXJ3 -0.44 0.00052 0.05 0.56589 miRNATAP -0.14 0.00051 NA
67 hsa-miR-27b-3p FOXK1 -0.44 0.00052 0.73 0 mirMAP -0.15 0.02761 NA
68 hsa-miR-27b-3p FOXN2 -0.44 0.00052 0.6 0 MirTarget -0.23 1.0E-5 NA
69 hsa-miR-27b-3p FRYL -0.44 0.00052 0.08 0.46484 miRNATAP -0.18 0.00039 NA
70 hsa-miR-27b-3p GATC -0.44 0.00052 0.41 0 MirTarget; miRNATAP -0.16 2.0E-5 NA
71 hsa-miR-27b-3p GCC2 -0.44 0.00052 0.37 0.00208 miRNATAP -0.17 0.0041 NA
72 hsa-miR-27b-3p GFPT1 -0.44 0.00052 0.45 0.00217 miRNATAP -0.2 0.00485 NA
73 hsa-miR-27b-3p GNB4 -0.44 0.00052 -0.06 0.76083 miRNAWalker2 validate -0.2 0.04726 NA
74 hsa-miR-27b-3p GNS -0.44 0.00052 0.44 6.0E-5 miRNATAP -0.16 0.00364 NA
75 hsa-miR-27b-3p GSK3B -0.44 0.00052 0.27 0.00045 miRNATAP -0.11 0.00277 NA
76 hsa-miR-27b-3p GXYLT1 -0.44 0.00052 0.64 0 miRNATAP -0.24 1.0E-5 NA
77 hsa-miR-27b-3p HMGB3 -0.44 0.00052 1.54 0 mirMAP; miRNATAP -0.22 0.02954 27363334 MiR 27b is epigenetically downregulated in tamoxifen resistant breast cancer cells due to promoter methylation and regulates tamoxifen sensitivity by targeting HMGB3; By using bioinformatics analysis and following dual luciferase and western blot analysis this study confirmed a direct regulation of miR-27b on HMGB3 expression by binding to the 3'UTR; In addition this study also found that silencing of HMGB3 indeed partially phenocopied the effects of miR-27b in reducing tamoxifen resistance and cell invasion and in reversing EMT-like properties; Therefore we infer that HMGB3 is a functional target of miR-27b in modulation of tamoxifen resistance and EMT
78 hsa-miR-27b-3p HNRNPA2B1 -0.44 0.00052 0.55 0 miRNAWalker2 validate -0.14 0.00083 NA
79 hsa-miR-27b-3p HNRNPU -0.44 0.00052 0.54 0 miRNAWalker2 validate -0.14 0.00015 NA
80 hsa-miR-27b-3p HSPD1 -0.44 0.00052 1.09 0 MirTarget -0.23 0.00161 NA
81 hsa-miR-27b-3p ICOS -0.44 0.00052 0.93 0.00205 miRNATAP -0.51 0.00058 NA
82 hsa-miR-27b-3p IKZF1 -0.44 0.00052 -0.16 0.54923 miRNATAP -0.31 0.01827 NA
83 hsa-miR-27b-3p INO80D -0.44 0.00052 0.37 0.00025 miRNATAP -0.15 0.0033 NA
84 hsa-miR-27b-3p INSR -0.44 0.00052 0.32 0.00889 miRNATAP -0.19 0.00152 NA
85 hsa-miR-27b-3p IQGAP2 -0.44 0.00052 -0.27 0.32247 MirTarget -0.3 0.02413 NA
86 hsa-miR-27b-3p ITGA2 -0.44 0.00052 1.18 0 miRNATAP -0.26 0.01244 NA
87 hsa-miR-27b-3p KBTBD8 -0.44 0.00052 -0.36 0.06268 MirTarget -0.22 0.02127 NA
88 hsa-miR-27b-3p KHSRP -0.44 0.00052 0.44 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.1 0.01659 NA
89 hsa-miR-27b-3p KIF21B -0.44 0.00052 1.12 0 miRNATAP -0.24 0.01793 NA
90 hsa-miR-27b-3p KIF3A -0.44 0.00052 0.43 0.00056 miRNATAP -0.21 0.00071 NA
91 hsa-miR-27b-3p KRAS -0.44 0.00052 0.3 0.11079 miRNATAP -0.23 0.0109 NA
92 hsa-miR-27b-3p LARP4 -0.44 0.00052 0.41 0.00013 MirTarget; miRNATAP -0.13 0.01736 NA
93 hsa-miR-27b-3p LBR -0.44 0.00052 0.42 0.00147 MirTarget -0.25 0.00011 NA
94 hsa-miR-27b-3p LIMK1 -0.44 0.00052 1.08 0 MirTarget; miRNATAP -0.19 0.00312 NA
95 hsa-miR-27b-3p LMLN -0.44 0.00052 0.6 0 MirTarget -0.17 0.00467 NA
96 hsa-miR-27b-3p LOX -0.44 0.00052 1.16 0 miRNATAP -0.3 0.00567 NA
97 hsa-miR-27b-3p LPIN1 -0.44 0.00052 -0.29 0.03939 miRNATAP -0.16 0.01808 NA
98 hsa-miR-27b-3p LRIG3 -0.44 0.00052 0.19 0.20919 miRNAWalker2 validate -0.26 0.00036 NA
99 hsa-miR-27b-3p LRRC58 -0.44 0.00052 0.67 0 mirMAP -0.19 0.00021 NA
100 hsa-miR-27b-3p LRRC8B -0.44 0.00052 0.79 0 MirTarget -0.21 0.0005 NA
101 hsa-miR-27b-3p LSM11 -0.44 0.00052 0.27 0.02929 mirMAP -0.16 0.00829 NA
102 hsa-miR-27b-3p MANEAL -0.44 0.00052 0.93 7.0E-5 miRNATAP -0.43 0.00019 NA
103 hsa-miR-27b-3p MAP3K2 -0.44 0.00052 0.15 0.05862 miRNATAP -0.1 0.00809 NA
104 hsa-miR-27b-3p MARCH1 -0.44 0.00052 0.59 0.00069 miRNATAP -0.29 0.00073 NA
105 hsa-miR-27b-3p MDM4 -0.44 0.00052 0.35 0.00762 miRNATAP -0.18 0.00452 NA
106 hsa-miR-27b-3p MIER3 -0.44 0.00052 -0.21 0.04957 MirTarget; miRNATAP -0.2 0.0001 NA
107 hsa-miR-27b-3p MMD -0.44 0.00052 0.36 0.01687 miRNATAP -0.19 0.00872 NA
108 hsa-miR-27b-3p MOB1B -0.44 0.00052 0.2 0.15266 miRNATAP -0.16 0.01469 NA
109 hsa-miR-27b-3p MTMR4 -0.44 0.00052 0.12 0.20829 miRNATAP -0.1 0.03123 NA
110 hsa-miR-27b-3p NEDD4 -0.44 0.00052 0.02 0.89834 MirTarget; miRNATAP -0.17 0.02687 NA
111 hsa-miR-27b-3p NEK2 -0.44 0.00052 2.75 0 miRNATAP -0.3 0.04996 NA
112 hsa-miR-27b-3p NEK6 -0.44 0.00052 0.72 0 MirTarget; miRNATAP -0.2 0.00444 NA
113 hsa-miR-27b-3p NEO1 -0.44 0.00052 -0.11 0.50879 MirTarget; miRNATAP -0.2 0.01375 NA
114 hsa-miR-27b-3p NF1 -0.44 0.00052 0.51 0 MirTarget -0.12 0.01614 NA
115 hsa-miR-27b-3p NFAT5 -0.44 0.00052 0.46 0.00066 MirTarget -0.17 0.00901 NA
116 hsa-miR-27b-3p NHS -0.44 0.00052 0.92 2.0E-5 miRNATAP -0.38 0.00039 NA
117 hsa-miR-27b-3p NKTR -0.44 0.00052 0.38 0.00508 MirTarget -0.15 0.02399 NA
118 hsa-miR-27b-3p NR5A2 -0.44 0.00052 0.76 0.00708 miRNATAP -0.54 0.0001 NA
119 hsa-miR-27b-3p NRAS -0.44 0.00052 0.47 1.0E-5 miRNATAP -0.12 0.02288 NA
120 hsa-miR-27b-3p NRIP1 -0.44 0.00052 0.18 0.11844 MirTarget; miRNATAP -0.21 0.00023 NA
121 hsa-miR-27b-3p NSD1 -0.44 0.00052 0.33 0.00034 miRNATAP -0.14 0.00203 NA
122 hsa-miR-27b-3p NUP153 -0.44 0.00052 0.45 0 miRNATAP -0.17 0.00049 NA
123 hsa-miR-27b-3p NUS1 -0.44 0.00052 0.16 0.07344 MirTarget -0.16 0.00015 NA
124 hsa-miR-27b-3p NXT2 -0.44 0.00052 0.65 1.0E-5 MirTarget; miRNATAP -0.26 0.00036 NA
125 hsa-miR-27b-3p ONECUT2 -0.44 0.00052 3.29 0 miRNATAP -0.48 0.0408 NA
126 hsa-miR-27b-3p OPA1 -0.44 0.00052 0.1 0.26916 MirTarget; miRNATAP -0.11 0.01201 NA
127 hsa-miR-27b-3p PARD6B -0.44 0.00052 0.82 5.0E-5 MirTarget; miRNATAP -0.25 0.01158 NA
128 hsa-miR-27b-3p PATZ1 -0.44 0.00052 0.52 0 miRNATAP -0.12 0.02922 NA
129 hsa-miR-27b-3p PDDC1 -0.44 0.00052 0.26 0.00574 mirMAP -0.1 0.02309 NA
130 hsa-miR-27b-3p PDPK1 -0.44 0.00052 0.02 0.82117 miRNATAP -0.12 0.00554 NA
131 hsa-miR-27b-3p PDS5B -0.44 0.00052 0.26 0.00962 MirTarget; miRNATAP -0.17 0.00031 NA
132 hsa-miR-27b-3p PDZK1IP1 -0.44 0.00052 0.72 0.11466 miRNATAP -0.49 0.02778 NA
133 hsa-miR-27b-3p PHLPP2 -0.44 0.00052 -0.06 0.72416 MirTarget; miRNATAP -0.16 0.04015 NA
134 hsa-miR-27b-3p PIKFYVE -0.44 0.00052 0.18 0.09549 MirTarget -0.16 0.00203 NA
135 hsa-miR-27b-3p PKN2 -0.44 0.00052 0.13 0.24299 miRNATAP -0.18 0.00084 NA
136 hsa-miR-27b-3p PLEKHH1 -0.44 0.00052 0.16 0.3477 miRNATAP -0.17 0.04391 NA
137 hsa-miR-27b-3p PODXL -0.44 0.00052 1.4 0 mirMAP -0.18 0.02058 NA
138 hsa-miR-27b-3p POGLUT1 -0.44 0.00052 0.39 0 MirTarget; miRNATAP -0.13 0.00138 NA
139 hsa-miR-27b-3p POGZ -0.44 0.00052 0.29 0.00149 miRNAWalker2 validate -0.1 0.02075 NA
140 hsa-miR-27b-3p PRR14L -0.44 0.00052 0.43 3.0E-5 miRNATAP -0.16 0.00108 NA
141 hsa-miR-27b-3p PRR16 -0.44 0.00052 0.48 0.00817 MirTarget -0.18 0.03982 NA
142 hsa-miR-27b-3p PRR3 -0.44 0.00052 0.33 0.00062 miRNAWalker2 validate -0.12 0.01269 NA
143 hsa-miR-27b-3p RAB3IP -0.44 0.00052 1.05 0 MirTarget -0.16 0.03546 NA
144 hsa-miR-27b-3p RAP1B -0.44 0.00052 -0.11 0.24787 MirTarget -0.12 0.0085 NA
145 hsa-miR-27b-3p RAP2C -0.44 0.00052 0.25 0.0042 miRNATAP -0.18 2.0E-5 NA
146 hsa-miR-27b-3p RAPGEF2 -0.44 0.00052 -0.12 0.18018 MirTarget; miRNATAP -0.11 0.01346 NA
147 hsa-miR-27b-3p RBBP5 -0.44 0.00052 0.46 0 miRNATAP -0.11 0.00389 NA
148 hsa-miR-27b-3p RGS1 -0.44 0.00052 0.13 0.59998 MirTarget; miRNATAP -0.4 0.00116 NA
149 hsa-miR-27b-3p RICTOR -0.44 0.00052 0.39 0.00188 miRNATAP -0.17 0.00573 NA
150 hsa-miR-27b-3p RNF207 -0.44 0.00052 0.96 0 miRNATAP -0.27 0.00167 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELL CYCLE 37 1316 2.474e-07 0.001151
2 CELL DIVISION 19 460 1.306e-06 0.001519
3 RESPONSE TO ENDOGENOUS STIMULUS 38 1450 9.519e-07 0.001519
4 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 30 1008 1.235e-06 0.001519
5 REGULATION OF CATABOLIC PROCESS 24 731 3.017e-06 0.002807
6 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 18 448 3.685e-06 0.002858
7 REGULATION OF CELL CYCLE PROCESS 20 558 5.861e-06 0.003896
8 PROTEIN PHOSPHORYLATION 27 944 9.11e-06 0.005179
9 REGULATION OF CELL CYCLE 27 949 1.002e-05 0.005179
10 INTRACELLULAR SIGNAL TRANSDUCTION 37 1572 1.576e-05 0.007332
11 CELLULAR RESPONSE TO NITROGEN COMPOUND 18 505 1.876e-05 0.007935
12 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 41 1848 2.071e-05 0.008029
13 POSITIVE REGULATION OF GENE EXPRESSION 39 1733 2.487e-05 0.008884
14 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 35 1492 2.962e-05 0.008884
15 RESPONSE TO GROWTH FACTOR 17 475 3.055e-05 0.008884
16 POSITIVE REGULATION OF CELL CYCLE 14 332 2.681e-05 0.008884
NumGOOverlapSizeP ValueAdj. P Value
1 RIBONUCLEOTIDE BINDING 43 1860 4.465e-06 0.002182
2 ENZYME BINDING 41 1737 4.697e-06 0.002182
3 ADENYL NUCLEOTIDE BINDING 36 1514 1.678e-05 0.005198
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Regulation_of_actin_cytoskeleton_hsa04810 13 208 7.445e-07 3.141e-05
2 mTOR_signaling_pathway_hsa04150 11 151 1.208e-06 3.141e-05
3 p53_signaling_pathway_hsa04115 7 68 1.158e-05 0.0001585
4 PI3K_Akt_signaling_pathway_hsa04151 15 352 1.22e-05 0.0001585
5 Focal_adhesion_hsa04510 8 199 0.001965 0.02044
6 Rap1_signaling_pathway_hsa04015 8 206 0.002436 0.02063
7 ErbB_signaling_pathway_hsa04012 5 85 0.002778 0.02063
8 Gap_junction_hsa04540 5 88 0.003229 0.02099
9 Apoptosis_hsa04210 6 138 0.004861 0.02599
10 Ras_signaling_pathway_hsa04014 8 232 0.004998 0.02599
11 Apoptosis_multiple_species_hsa04215 3 33 0.006051 0.02842
12 MAPK_signaling_pathway_hsa04010 9 295 0.006558 0.02842
13 Sphingolipid_signaling_pathway_hsa04071 5 118 0.011 0.04399
14 Autophagy_animal_hsa04140 5 128 0.0152 0.05555
15 Hedgehog_signaling_pathway_hsa04340 3 47 0.01603 0.05555
16 FoxO_signaling_pathway_hsa04068 5 132 0.01715 0.05574
17 Apelin_signaling_pathway_hsa04371 5 137 0.01981 0.06059
18 Phospholipase_D_signaling_pathway_hsa04072 5 146 0.02524 0.07292
19 Hippo_signaling_pathway_hsa04390 5 154 0.0308 0.08431
20 TNF_signaling_pathway_hsa04668 4 108 0.03424 0.08901
21 AMPK_signaling_pathway_hsa04152 4 121 0.04856 0.1203
22 ECM_receptor_interaction_hsa04512 3 82 0.06589 0.1557
23 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 4 139 0.07306 0.1652
24 Cellular_senescence_hsa04218 4 160 0.1081 0.2343
25 cGMP_PKG_signaling_pathway_hsa04022 4 163 0.1137 0.2364
26 Tight_junction_hsa04530 4 170 0.127 0.2541
27 VEGF_signaling_pathway_hsa04370 2 59 0.1435 0.2763
28 Cell_cycle_hsa04110 3 124 0.1655 0.2998
29 Mitophagy_animal_hsa04137 2 65 0.1672 0.2998
30 cAMP_signaling_pathway_hsa04024 4 198 0.1864 0.3231
31 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.2257 0.3717
32 Wnt_signaling_pathway_hsa04310 3 146 0.2287 0.3717
33 Phagosome_hsa04145 3 152 0.2467 0.3887
34 Necroptosis_hsa04217 3 164 0.2833 0.4208
35 NF_kappa_B_signaling_pathway_hsa04064 2 95 0.2915 0.421
36 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.3082 0.4274
37 HIF_1_signaling_pathway_hsa04066 2 100 0.3123 0.4274
38 Calcium_signaling_pathway_hsa04020 3 182 0.3388 0.4517
39 Jak_STAT_signaling_pathway_hsa04630 2 162 0.5486 0.6765
40 Endocytosis_hsa04144 2 244 0.7652 0.8289
41 Cytokine_cytokine_receptor_interaction_hsa04060 2 270 0.812 0.8617

Quest ID: 59ecf025a1348b5946341c7c285857b7