This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are
presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.
"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.
Num | microRNA | Gene | miRNA log2FC | miRNA pvalue | Gene log2FC | Gene pvalue | Interaction | Correlation beta | Correlation P-value | PMID | Reported in cancer studies |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | hsa-miR-204-5p | ABCC1 | -0.54 | 0.03309 | 0.51 | 0.02094 | mirMAP | -0.19 | 1.0E-5 | NA | |
2 | hsa-miR-204-5p | ACSL4 | -0.54 | 0.03309 | 2.07 | 0 | MirTarget | -0.37 | 0 | NA | |
3 | hsa-miR-204-5p | ADAM12 | -0.54 | 0.03309 | 0.93 | 0.0022 | mirMAP | -0.39 | 0 | NA | |
4 | hsa-miR-204-5p | AGPAT4 | -0.54 | 0.03309 | 0.87 | 7.0E-5 | mirMAP | -0.18 | 2.0E-5 | NA | |
5 | hsa-miR-204-5p | ANKRD13A | -0.54 | 0.03309 | 0.13 | 0.08958 | MirTarget; miRNATAP | -0.11 | 0 | NA | |
6 | hsa-miR-204-5p | APH1B | -0.54 | 0.03309 | 0.16 | 0.22729 | MirTarget | -0.1 | 6.0E-5 | NA | |
7 | hsa-miR-204-5p | ARAP2 | -0.54 | 0.03309 | -1.13 | 0 | MirTarget; miRNATAP | -0.19 | 0 | NA | |
8 | hsa-miR-204-5p | ARID3A | -0.54 | 0.03309 | 1.53 | 0 | mirMAP | -0.23 | 0 | NA | |
9 | hsa-miR-204-5p | ARID3B | -0.54 | 0.03309 | 0.46 | 0.00021 | MirTarget | -0.11 | 0 | NA | |
10 | hsa-miR-204-5p | ARL4C | -0.54 | 0.03309 | -0.83 | 1.0E-5 | MirTarget | -0.12 | 0.00077 | NA | |
11 | hsa-miR-204-5p | ARNT2 | -0.54 | 0.03309 | -0.54 | 0.16571 | mirMAP | -0.26 | 0.00052 | NA | |
12 | hsa-miR-204-5p | ARRB1 | -0.54 | 0.03309 | -0.7 | 0.00013 | MirTarget | -0.16 | 0 | NA | |
13 | hsa-miR-204-5p | ATP10B | -0.54 | 0.03309 | -0.24 | 0.56639 | MirTarget | -0.36 | 1.0E-5 | NA | |
14 | hsa-miR-204-5p | ATP8A1 | -0.54 | 0.03309 | -0.16 | 0.36366 | MirTarget; miRNATAP | -0.11 | 0.00109 | NA | |
15 | hsa-miR-204-5p | ATP8B1 | -0.54 | 0.03309 | 0.33 | 0.02038 | MirTarget; miRNATAP | -0.17 | 0 | NA | |
16 | hsa-miR-204-5p | B3GAT1 | -0.54 | 0.03309 | -3.43 | 0 | MirTarget | -0.29 | 0.00122 | NA | |
17 | hsa-miR-204-5p | B3GNT5 | -0.54 | 0.03309 | 0.79 | 0.0009 | MirTarget | -0.11 | 0.01359 | NA | |
18 | hsa-miR-204-5p | BCAT1 | -0.54 | 0.03309 | 1.33 | 0 | mirMAP | -0.16 | 2.0E-5 | NA | |
19 | hsa-miR-204-5p | BCL11B | -0.54 | 0.03309 | -0.59 | 0.01365 | MirTarget; miRNATAP | -0.12 | 0.01059 | NA | |
20 | hsa-miR-204-5p | BEND6 | -0.54 | 0.03309 | 0.34 | 0.26138 | mirMAP | -0.21 | 0.00031 | NA | |
21 | hsa-miR-204-5p | BEX2 | -0.54 | 0.03309 | 0.26 | 0.59709 | miRNAWalker2 validate | -0.43 | 0 | NA | |
22 | hsa-miR-204-5p | BNC2 | -0.54 | 0.03309 | -0.39 | 0.08973 | miRNATAP | -0.13 | 0.00223 | NA | |
23 | hsa-miR-204-5p | C17orf51 | -0.54 | 0.03309 | -0.67 | 0.00164 | mirMAP | -0.11 | 0.01026 | NA | |
24 | hsa-miR-204-5p | C20orf194 | -0.54 | 0.03309 | 0.24 | 0.07938 | miRNATAP | -0.11 | 4.0E-5 | NA | |
25 | hsa-miR-204-5p | CA12 | -0.54 | 0.03309 | 2.34 | 0 | mirMAP | -0.4 | 1.0E-5 | NA | |
26 | hsa-miR-204-5p | CCDC149 | -0.54 | 0.03309 | -0.21 | 0.24018 | mirMAP | -0.23 | 0 | NA | |
27 | hsa-miR-204-5p | CCNJ | -0.54 | 0.03309 | -0.4 | 0.0818 | miRNATAP | -0.1 | 0.01765 | NA | |
28 | hsa-miR-204-5p | CCR5 | -0.54 | 0.03309 | -0.54 | 0.01525 | mirMAP | -0.13 | 0.00204 | NA | |
29 | hsa-miR-204-5p | CDC25B | -0.54 | 0.03309 | 0.8 | 0 | miRNATAP | -0.16 | 0 | NA | |
30 | hsa-miR-204-5p | CDH6 | -0.54 | 0.03309 | -0.01 | 0.96649 | mirMAP | -0.26 | 0 | NA | |
31 | hsa-miR-204-5p | CDX2 | -0.54 | 0.03309 | 0.69 | 0.03601 | miRNAWalker2 validate | -0.14 | 0.02563 | NA | |
32 | hsa-miR-204-5p | CENPL | -0.54 | 0.03309 | 2.09 | 0 | MirTarget | -0.13 | 4.0E-5 | NA | |
33 | hsa-miR-204-5p | CENPO | -0.54 | 0.03309 | 0.94 | 0 | mirMAP | -0.14 | 1.0E-5 | NA | |
34 | hsa-miR-204-5p | CHML | -0.54 | 0.03309 | 1.36 | 0 | mirMAP | -0.2 | 0 | NA | |
35 | hsa-miR-204-5p | CLIP3 | -0.54 | 0.03309 | -0.13 | 0.4997 | mirMAP | -0.14 | 0.00011 | NA | |
36 | hsa-miR-204-5p | CREB5 | -0.54 | 0.03309 | 0 | 0.99313 | miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP | -0.1 | 0.00867 | NA | |
37 | hsa-miR-204-5p | CSF2RB | -0.54 | 0.03309 | -0.51 | 0.00683 | MirTarget | -0.11 | 0.00224 | NA | |
38 | hsa-miR-204-5p | CXCL3 | -0.54 | 0.03309 | -1.05 | 0.00114 | miRNAWalker2 validate | -0.27 | 1.0E-5 | NA | |
39 | hsa-miR-204-5p | DACT3 | -0.54 | 0.03309 | -1.19 | 0 | mirMAP | -0.14 | 0.00211 | NA | |
40 | hsa-miR-204-5p | DCAF4L1 | -0.54 | 0.03309 | 1.83 | 0 | mirMAP | -0.12 | 0.01186 | NA | |
41 | hsa-miR-204-5p | DOK6 | -0.54 | 0.03309 | -1.91 | 0 | mirMAP | -0.15 | 0.01921 | NA | |
42 | hsa-miR-204-5p | DTX4 | -0.54 | 0.03309 | -0.32 | 0.16271 | miRNATAP | -0.29 | 0 | NA | |
43 | hsa-miR-204-5p | E2F2 | -0.54 | 0.03309 | 2.82 | 0 | mirMAP | -0.27 | 0 | NA | |
44 | hsa-miR-204-5p | EFNA5 | -0.54 | 0.03309 | -1.36 | 0.00069 | miRNATAP | -0.39 | 0 | NA | |
45 | hsa-miR-204-5p | EPB41L1 | -0.54 | 0.03309 | 0.13 | 0.60566 | mirMAP | -0.27 | 0 | NA | |
46 | hsa-miR-204-5p | ESCO2 | -0.54 | 0.03309 | 1.8 | 0 | MirTarget | -0.19 | 4.0E-5 | NA | |
47 | hsa-miR-204-5p | EVC | -0.54 | 0.03309 | -1.28 | 0.00058 | mirMAP | -0.38 | 0 | NA | |
48 | hsa-miR-204-5p | EVC2 | -0.54 | 0.03309 | -0.67 | 0.04932 | MirTarget | -0.38 | 0 | NA | |
49 | hsa-miR-204-5p | EZR | -0.54 | 0.03309 | -0.62 | 2.0E-5 | miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP | -0.15 | 0 | 21416062 | MiR-204 which was predicted to target ezrin was downregulated in gastric cancer cells and gastric carcinomas n=22 p<0.01; MiR-204 inhibited ezrin expression Ras activation cell growth and cell migration; Importantly miR-204 suppressed the expression of luciferase controlled by wild-type but not mutated ezrin 3'-UTR; By contributing to ezrin upregulation miR-204 downregulation represents a novel mechanism for aberrant Ras activation in gastric carcinogenesis |
50 | hsa-miR-204-5p | FA2H | -0.54 | 0.03309 | -1.26 | 0.00271 | mirMAP | -0.55 | 0 | NA | |
51 | hsa-miR-204-5p | FAM117B | -0.54 | 0.03309 | 0.1 | 0.44264 | MirTarget; miRNATAP | -0.11 | 4.0E-5 | NA | |
52 | hsa-miR-204-5p | FAT3 | -0.54 | 0.03309 | -0.4 | 0.11828 | mirMAP | -0.14 | 0.00431 | NA | |
53 | hsa-miR-204-5p | FBN2 | -0.54 | 0.03309 | -0.53 | 0.03693 | MirTarget; miRNATAP | -0.15 | 0.00165 | NA | |
54 | hsa-miR-204-5p | FBXO41 | -0.54 | 0.03309 | 0.4 | 0.10243 | mirMAP | -0.25 | 0 | NA | |
55 | hsa-miR-204-5p | FIGN | -0.54 | 0.03309 | -1.2 | 0 | mirMAP | -0.1 | 0.0353 | NA | |
56 | hsa-miR-204-5p | FMNL3 | -0.54 | 0.03309 | 0.67 | 0 | mirMAP | -0.13 | 0 | NA | |
57 | hsa-miR-204-5p | FRMD4A | -0.54 | 0.03309 | -0.3 | 0.03693 | miRNATAP | -0.13 | 0 | NA | |
58 | hsa-miR-204-5p | FZD1 | -0.54 | 0.03309 | -0.99 | 0 | miRNAWalker2 validate; miRTarBase | -0.19 | 0 | NA | |
59 | hsa-miR-204-5p | GABRB3 | -0.54 | 0.03309 | -4.17 | 0 | miRNATAP | -0.24 | 0.02753 | NA | |
60 | hsa-miR-204-5p | GALNT10 | -0.54 | 0.03309 | 0.83 | 0 | mirMAP | -0.1 | 4.0E-5 | NA | |
61 | hsa-miR-204-5p | GAS7 | -0.54 | 0.03309 | -0.08 | 0.67602 | mirMAP | -0.21 | 0 | NA | |
62 | hsa-miR-204-5p | GJC1 | -0.54 | 0.03309 | 2.11 | 0 | mirMAP | -0.15 | 0.0001 | NA | |
63 | hsa-miR-204-5p | GLIS3 | -0.54 | 0.03309 | -0.85 | 0.00069 | MirTarget; miRNATAP | -0.41 | 0 | NA | |
64 | hsa-miR-204-5p | HAS2 | -0.54 | 0.03309 | -2.63 | 0 | miRNAWalker2 validate; MirTarget | -0.32 | 2.0E-5 | NA | |
65 | hsa-miR-204-5p | HES2 | -0.54 | 0.03309 | 1.81 | 0 | mirMAP | -0.4 | 0 | NA | |
66 | hsa-miR-204-5p | IGF1R | -0.54 | 0.03309 | -0.7 | 0.00354 | mirMAP | -0.18 | 0.00017 | NA | |
67 | hsa-miR-204-5p | IL1RAP | -0.54 | 0.03309 | -2.29 | 0 | miRNAWalker2 validate | -0.1 | 0.01277 | NA | |
68 | hsa-miR-204-5p | ITPRIPL2 | -0.54 | 0.03309 | 0.02 | 0.83591 | mirMAP | -0.13 | 0 | NA | |
69 | hsa-miR-204-5p | KCNK3 | -0.54 | 0.03309 | -2.08 | 0 | mirMAP | -0.18 | 0.0066 | NA | |
70 | hsa-miR-204-5p | KCNT2 | -0.54 | 0.03309 | -1.03 | 0.00026 | MirTarget | -0.23 | 2.0E-5 | NA | |
71 | hsa-miR-204-5p | KCTD1 | -0.54 | 0.03309 | 0.62 | 1.0E-5 | miRNATAP | -0.14 | 0 | NA | |
72 | hsa-miR-204-5p | KIAA1671 | -0.54 | 0.03309 | -0.84 | 0 | mirMAP | -0.17 | 0 | NA | |
73 | hsa-miR-204-5p | KIF26B | -0.54 | 0.03309 | 0.15 | 0.64008 | mirMAP | -0.18 | 0.00403 | NA | |
74 | hsa-miR-204-5p | KLHL29 | -0.54 | 0.03309 | 0.7 | 0.01093 | MirTarget; miRNATAP | -0.45 | 0 | NA | |
75 | hsa-miR-204-5p | LGI2 | -0.54 | 0.03309 | 0.88 | 0.00041 | mirMAP | -0.29 | 0 | NA | |
76 | hsa-miR-204-5p | LGR4 | -0.54 | 0.03309 | -0.79 | 0 | MirTarget | -0.1 | 0.00011 | NA | |
77 | hsa-miR-204-5p | LIF | -0.54 | 0.03309 | -0.72 | 0.03257 | mirMAP | -0.33 | 0 | NA | |
78 | hsa-miR-204-5p | LONRF2 | -0.54 | 0.03309 | -1.04 | 0.00952 | mirMAP | -0.25 | 0.00098 | NA | |
79 | hsa-miR-204-5p | LPAR1 | -0.54 | 0.03309 | -2.14 | 0 | MirTarget; miRNATAP | -0.13 | 0.04479 | NA | |
80 | hsa-miR-204-5p | MCC | -0.54 | 0.03309 | -2.37 | 0 | mirMAP | -0.18 | 0.00026 | NA | |
81 | hsa-miR-204-5p | MGAT5 | -0.54 | 0.03309 | -0.05 | 0.8656 | MirTarget; mirMAP | -0.16 | 0.0035 | NA | |
82 | hsa-miR-204-5p | MIDN | -0.54 | 0.03309 | -0.47 | 7.0E-5 | mirMAP | -0.13 | 0 | NA | |
83 | hsa-miR-204-5p | MLLT3 | -0.54 | 0.03309 | -0.15 | 0.54206 | MirTarget; miRNATAP | -0.16 | 0.00065 | NA | |
84 | hsa-miR-204-5p | MMP16 | -0.54 | 0.03309 | -0.56 | 0.04845 | MirTarget | -0.2 | 0.00026 | NA | |
85 | hsa-miR-204-5p | MSI2 | -0.54 | 0.03309 | 0.66 | 0.0001 | mirMAP | -0.12 | 0.00023 | NA | |
86 | hsa-miR-204-5p | MTMR7 | -0.54 | 0.03309 | 0.48 | 0.04505 | MirTarget | -0.15 | 0.00108 | NA | |
87 | hsa-miR-204-5p | NAV1 | -0.54 | 0.03309 | 0.46 | 0.0015 | mirMAP | -0.12 | 2.0E-5 | NA | |
88 | hsa-miR-204-5p | NBEA | -0.54 | 0.03309 | -0.95 | 0.00035 | MirTarget; miRNATAP | -0.2 | 9.0E-5 | NA | |
89 | hsa-miR-204-5p | NCALD | -0.54 | 0.03309 | -1.08 | 0 | miRNATAP | -0.22 | 0 | NA | |
90 | hsa-miR-204-5p | NCOA7 | -0.54 | 0.03309 | -1.09 | 0 | miRNATAP | -0.11 | 0.00046 | NA | |
91 | hsa-miR-204-5p | NOVA1 | -0.54 | 0.03309 | -0.24 | 0.49024 | miRNATAP | -0.28 | 2.0E-5 | NA | |
92 | hsa-miR-204-5p | NOX4 | -0.54 | 0.03309 | 2.86 | 0 | MirTarget | -0.15 | 0.0007 | NA | |
93 | hsa-miR-204-5p | NPTX1 | -0.54 | 0.03309 | 0.93 | 0.00584 | miRNATAP | -0.31 | 0 | NA | |
94 | hsa-miR-204-5p | NXPH4 | -0.54 | 0.03309 | 3.7 | 0 | MirTarget | -0.51 | 0 | NA | |
95 | hsa-miR-204-5p | ORAI2 | -0.54 | 0.03309 | 0.15 | 0.33665 | mirMAP | -0.17 | 0 | NA | |
96 | hsa-miR-204-5p | OSBPL6 | -0.54 | 0.03309 | -0.98 | 7.0E-5 | mirMAP | -0.1 | 0.02946 | NA | |
97 | hsa-miR-204-5p | PAQR4 | -0.54 | 0.03309 | 1.85 | 0 | MirTarget | -0.21 | 0 | NA | |
98 | hsa-miR-204-5p | PERP | -0.54 | 0.03309 | -0.73 | 3.0E-5 | MirTarget | -0.16 | 0 | NA | |
99 | hsa-miR-204-5p | PFKFB3 | -0.54 | 0.03309 | -1.31 | 0 | mirMAP | -0.2 | 2.0E-5 | NA | |
100 | hsa-miR-204-5p | PIK3CB | -0.54 | 0.03309 | 0.1 | 0.16595 | miRNATAP | -0.11 | 0 | NA | |
101 | hsa-miR-204-5p | PLAUR | -0.54 | 0.03309 | -0.88 | 3.0E-5 | miRNAWalker2 validate | -0.21 | 0 | NA | |
102 | hsa-miR-204-5p | PLCH2 | -0.54 | 0.03309 | 0.58 | 0.12624 | mirMAP | -0.32 | 1.0E-5 | NA | |
103 | hsa-miR-204-5p | PLXDC2 | -0.54 | 0.03309 | -0.45 | 0.04873 | MirTarget | -0.15 | 0.00079 | NA | |
104 | hsa-miR-204-5p | PRDM16 | -0.54 | 0.03309 | -0.04 | 0.92052 | mirMAP | -0.16 | 0.01576 | NA | |
105 | hsa-miR-204-5p | PREX1 | -0.54 | 0.03309 | 0.19 | 0.18394 | mirMAP | -0.13 | 1.0E-5 | NA | |
106 | hsa-miR-204-5p | PRRX1 | -0.54 | 0.03309 | 2.14 | 0 | MirTarget; miRNATAP | -0.19 | 0.00022 | NA | |
107 | hsa-miR-204-5p | RAB11FIP1 | -0.54 | 0.03309 | 0.11 | 0.53355 | mirMAP | -0.17 | 0 | NA | |
108 | hsa-miR-204-5p | RAB11FIP4 | -0.54 | 0.03309 | 1.54 | 0 | mirMAP | -0.19 | 0 | NA | |
109 | hsa-miR-204-5p | RAB3B | -0.54 | 0.03309 | 2.31 | 0 | mirMAP | -0.32 | 1.0E-5 | NA | |
110 | hsa-miR-204-5p | RAB3C | -0.54 | 0.03309 | 0.18 | 0.69641 | mirMAP | -0.22 | 0.01366 | NA | |
111 | hsa-miR-204-5p | RAB3IP | -0.54 | 0.03309 | 0.19 | 0.14367 | mirMAP | -0.15 | 0 | NA | |
112 | hsa-miR-204-5p | RAP1GAP2 | -0.54 | 0.03309 | -0.15 | 0.59168 | miRNATAP | -0.19 | 0.00049 | NA | |
113 | hsa-miR-204-5p | RASA3 | -0.54 | 0.03309 | -0.59 | 0.00186 | MirTarget | -0.19 | 0 | NA | |
114 | hsa-miR-204-5p | RASSF3 | -0.54 | 0.03309 | -0.25 | 0.41625 | mirMAP | -0.26 | 1.0E-5 | NA | |
115 | hsa-miR-204-5p | RELL1 | -0.54 | 0.03309 | -0.14 | 0.22164 | MirTarget | -0.12 | 0 | NA | |
116 | hsa-miR-204-5p | RELT | -0.54 | 0.03309 | 0.23 | 0.12682 | MirTarget | -0.19 | 0 | NA | |
117 | hsa-miR-204-5p | RET | -0.54 | 0.03309 | -3.78 | 0 | MirTarget | -0.2 | 0.00878 | NA | |
118 | hsa-miR-204-5p | RIMS3 | -0.54 | 0.03309 | 0.89 | 1.0E-5 | mirMAP | -0.12 | 0.00203 | NA | |
119 | hsa-miR-204-5p | RTKN2 | -0.54 | 0.03309 | 2.58 | 0 | MirTarget; miRNATAP | -0.34 | 0 | NA | |
120 | hsa-miR-204-5p | RUNX2 | -0.54 | 0.03309 | -0.63 | 0.00682 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.13 | 0.00549 | NA | |
121 | hsa-miR-204-5p | SAMD5 | -0.54 | 0.03309 | -3.18 | 0 | MirTarget | -0.35 | 1.0E-5 | NA | |
122 | hsa-miR-204-5p | SARM1 | -0.54 | 0.03309 | 0.71 | 0.00018 | mirMAP | -0.14 | 9.0E-5 | NA | |
123 | hsa-miR-204-5p | SGIP1 | -0.54 | 0.03309 | 0.5 | 0.05782 | MirTarget | -0.34 | 0 | NA | |
124 | hsa-miR-204-5p | SIX2 | -0.54 | 0.03309 | 2.88 | 0 | miRNATAP | -0.24 | 0.00169 | NA | |
125 | hsa-miR-204-5p | SLC25A24 | -0.54 | 0.03309 | -0.55 | 0.02457 | MirTarget | -0.22 | 0 | NA | |
126 | hsa-miR-204-5p | SLC37A3 | -0.54 | 0.03309 | 0.1 | 0.22472 | MirTarget | -0.11 | 0 | NA | |
127 | hsa-miR-204-5p | SLC45A4 | -0.54 | 0.03309 | 1.21 | 0 | mirMAP | -0.29 | 0 | NA | |
128 | hsa-miR-204-5p | SLC7A5 | -0.54 | 0.03309 | -0.14 | 0.55156 | mirMAP | -0.15 | 0.00073 | NA | |
129 | hsa-miR-204-5p | SNAI1 | -0.54 | 0.03309 | -1.12 | 0 | miRNAWalker2 validate | -0.17 | 0.00017 | 26729198 | miR 204 regulates the EMT by targeting snai1 to suppress the invasion and migration of gastric cancer; By building the epithelial-mesenchymal transition EMT model in vitro through the addition of transforming growth factor beta 1 TGF-β1 expressions of miR-204 and snai1 in the EMT model together with their respective effects on EMT were evaluated; The over-expression of miR-204 or downregulation of snai1 could significantly inhibit the metastasis and invasion of GC cells both in vitro and in vivo; The upregulated miR-204 expression or inhibited snai1 expression could suppress the EMT process in EMT in vitro models; Our study provided evidence that miR-204 may suppress the metastasis and invasion of GC cells through the regulation of the EMT process by targeting snai1 |
130 | hsa-miR-204-5p | SNX22 | -0.54 | 0.03309 | 0.82 | 0 | mirMAP | -0.16 | 0 | NA | |
131 | hsa-miR-204-5p | SOX11 | -0.54 | 0.03309 | 1.41 | 1.0E-5 | MirTarget; miRNATAP | -0.42 | 0 | NA | |
132 | hsa-miR-204-5p | SOX4 | -0.54 | 0.03309 | 0.75 | 0.00274 | miRNAWalker2 validate; miRNATAP | -0.21 | 1.0E-5 | 26323722; 24984017 | Upregulation of microRNA 204 inhibits cell proliferation migration and invasion in human renal cell carcinoma cells by downregulating SOX4;Decreased miR 204 in H pylori associated gastric cancer promotes cancer cell proliferation and invasion by targeting SOX4; Luciferase assay revealed that SOX4 was target gene of miR-204 which was found up-regulated in H pylori positive tissues; Down-regulation of miR-204 and over-expression of SOX4 promoted epithelial-mesenchymal transition process; Taken together our findings demonstrated that miR-204 may act as a tumor suppressor in H pylori induced gastric cancer by targeting SOX4 |
133 | hsa-miR-204-5p | SPRED1 | -0.54 | 0.03309 | -0.58 | 7.0E-5 | miRNATAP | -0.12 | 4.0E-5 | NA | |
134 | hsa-miR-204-5p | ST6GAL2 | -0.54 | 0.03309 | -3.94 | 0 | mirMAP | -0.19 | 0.01447 | NA | |
135 | hsa-miR-204-5p | STMN3 | -0.54 | 0.03309 | 0.14 | 0.56905 | miRNATAP | -0.19 | 2.0E-5 | NA | |
136 | hsa-miR-204-5p | STX3 | -0.54 | 0.03309 | 0.27 | 0.06205 | mirMAP | -0.22 | 0 | NA | |
137 | hsa-miR-204-5p | TANC2 | -0.54 | 0.03309 | -0.08 | 0.72319 | miRNATAP | -0.23 | 0 | NA | |
138 | hsa-miR-204-5p | TCF7L1 | -0.54 | 0.03309 | -0.13 | 0.40077 | MirTarget; miRNATAP | -0.16 | 0 | NA | |
139 | hsa-miR-204-5p | TFAP2A | -0.54 | 0.03309 | 1.05 | 0.00261 | miRNATAP | -0.3 | 1.0E-5 | NA | |
140 | hsa-miR-204-5p | TFEC | -0.54 | 0.03309 | -0.74 | 0.00042 | MirTarget | -0.1 | 0.01004 | NA | |
141 | hsa-miR-204-5p | THSD4 | -0.54 | 0.03309 | -1.03 | 3.0E-5 | MirTarget; miRNATAP | -0.22 | 0 | NA | |
142 | hsa-miR-204-5p | THY1 | -0.54 | 0.03309 | 2.72 | 0 | mirMAP | -0.2 | 0 | NA | |
143 | hsa-miR-204-5p | TMEM108 | -0.54 | 0.03309 | 0.99 | 4.0E-5 | MirTarget | -0.2 | 3.0E-5 | NA | |
144 | hsa-miR-204-5p | TMEM87B | -0.54 | 0.03309 | -0.16 | 0.10665 | MirTarget | -0.12 | 0 | NA | |
145 | hsa-miR-204-5p | TNFRSF11A | -0.54 | 0.03309 | 0.24 | 0.30724 | mirMAP | -0.33 | 0 | NA | |
146 | hsa-miR-204-5p | TPPP | -0.54 | 0.03309 | -0.47 | 0.06759 | MirTarget | -0.11 | 0.02786 | NA | |
147 | hsa-miR-204-5p | TTC39A | -0.54 | 0.03309 | 2.64 | 0 | mirMAP | -0.46 | 0 | NA | |
148 | hsa-miR-204-5p | TTYH1 | -0.54 | 0.03309 | -1.3 | 0.00103 | miRNATAP | -0.3 | 8.0E-5 | NA | |
149 | hsa-miR-204-5p | VDR | -0.54 | 0.03309 | 0.29 | 0.25305 | mirMAP | -0.1 | 0.0382 | NA | |
150 | hsa-miR-204-5p | VGLL3 | -0.54 | 0.03309 | -0.29 | 0.2354 | MirTarget; mirMAP | -0.11 | 0.0163 | NA |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|
1 | PALATE DEVELOPMENT | 8 | 85 | 3.651e-07 | 0.001699 |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|
Num | Pathway | Pathview | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|---|
1 | hsa04144_Endocytosis | 7 | 203 | 0.001173 | 0.2112 | |
2 | hsa00532_Glycosaminoglycan_biosynthesis_._chondroitin_sulfate | 2 | 22 | 0.01292 | 0.6937 | |
3 | hsa04062_Chemokine_signaling_pathway | 5 | 189 | 0.01725 | 0.6937 | |
4 | hsa00534_Glycosaminoglycan_biosynthesis_._heparan_sulfate | 2 | 26 | 0.0178 | 0.6937 | |
5 | hsa04520_Adherens_junction | 3 | 73 | 0.02011 | 0.6937 | |
6 | hsa04914_Progesterone.mediated_oocyte_maturation | 3 | 87 | 0.03166 | 0.6937 | |
7 | hsa00051_Fructose_and_mannose_metabolism | 2 | 36 | 0.03278 | 0.6937 | |
8 | hsa04210_Apoptosis | 3 | 89 | 0.03354 | 0.6937 | |
9 | hsa04630_Jak.STAT_signaling_pathway | 4 | 155 | 0.03468 | 0.6937 | |
10 | hsa00510_N.Glycan_biosynthesis | 2 | 49 | 0.05728 | 1 | |
11 | hsa04670_Leukocyte_transendothelial_migration | 3 | 117 | 0.06566 | 1 | |
12 | hsa04014_Ras_signaling_pathway | 4 | 236 | 0.1174 | 1 | |
13 | hsa04151_PI3K_AKT_signaling_pathway | 5 | 351 | 0.1457 | 1 | |
14 | hsa04916_Melanogenesis | 2 | 101 | 0.19 | 1 | |
15 | hsa04110_Cell_cycle | 2 | 128 | 0.2684 | 1 | |
16 | hsa04380_Osteoclast_differentiation | 2 | 128 | 0.2684 | 1 | |
17 | hsa04530_Tight_junction | 2 | 133 | 0.283 | 1 | |
18 | hsa04310_Wnt_signaling_pathway | 2 | 151 | 0.3353 | 1 | |
19 | hsa04390_Hippo_signaling_pathway | 2 | 154 | 0.344 | 1 | |
20 | hsa04510_Focal_adhesion | 2 | 200 | 0.4703 | 1 | |
21 | hsa04810_Regulation_of_actin_cytoskeleton | 2 | 214 | 0.5058 | 1 | |
22 | hsa04010_MAPK_signaling_pathway | 2 | 268 | 0.6278 | 1 |