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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-125a-5p ABHD2 -0.31 0.3708 0.63 0.15716 miRanda; mirMAP -0.27 0.00546 NA
2 hsa-miR-125a-5p ABHD3 -0.31 0.3708 0.21 0.58467 PITA; miRanda -0.18 0.02803 NA
3 hsa-miR-125a-5p ACPP -0.31 0.3708 0.84 0.23008 MirTarget; miRanda -0.61 6.0E-5 NA
4 hsa-miR-125a-5p ACTBL2 -0.31 0.3708 1.45 0.14365 miRanda -0.65 0.00258 NA
5 hsa-miR-125a-5p ACTG2 -0.31 0.3708 0.67 0.55281 miRanda -0.66 0.00735 NA
6 hsa-miR-125a-5p ACTL6A -0.31 0.3708 0.27 0.19205 miRanda -0.18 2.0E-5 NA
7 hsa-miR-125a-5p ACTN4 -0.31 0.3708 0.21 0.5222 mirMAP -0.22 0.0019 NA
8 hsa-miR-125a-5p ADAM9 -0.31 0.3708 0.41 0.38674 PITA; miRanda -0.25 0.01649 NA
9 hsa-miR-125a-5p ADAMTS14 -0.31 0.3708 -0.08 0.91758 miRanda; mirMAP -0.68 2.0E-5 NA
10 hsa-miR-125a-5p ADAMTS9 -0.31 0.3708 -0.6 0.25854 miRanda -0.26 0.02448 NA
11 hsa-miR-125a-5p ADAP1 -0.31 0.3708 1.46 0.03319 mirMAP -0.78 0 NA
12 hsa-miR-125a-5p ADH5 -0.31 0.3708 0.05 0.76619 miRanda -0.11 0.00468 NA
13 hsa-miR-125a-5p ADM2 -0.31 0.3708 0.38 0.58067 mirMAP -0.82 0 NA
14 hsa-miR-125a-5p AEN -0.31 0.3708 0.28 0.32652 miRanda -0.18 0.00325 NA
15 hsa-miR-125a-5p AGTRAP -0.31 0.3708 -0.09 0.79335 miRNAWalker2 validate; miRanda -0.2 0.00471 NA
16 hsa-miR-125a-5p AIFM1 -0.31 0.3708 0.08 0.68492 miRanda -0.11 0.00731 NA
17 hsa-miR-125a-5p AKAP13 -0.31 0.3708 -0.44 0.16463 miRanda -0.23 0.00085 NA
18 hsa-miR-125a-5p ALDH1A3 -0.31 0.3708 0.26 0.72786 miRanda -0.38 0.02042 NA
19 hsa-miR-125a-5p ALPK1 -0.31 0.3708 -0.37 0.36057 miRanda -0.52 0 NA
20 hsa-miR-125a-5p ANKS6 -0.31 0.3708 0.39 0.20456 MirTarget -0.17 0.00994 NA
21 hsa-miR-125a-5p ANO6 -0.31 0.3708 0.05 0.90255 miRanda -0.4 0 NA
22 hsa-miR-125a-5p ANPEP -0.31 0.3708 -0.43 0.66538 PITA; miRanda; miRNATAP -0.59 0.00702 NA
23 hsa-miR-125a-5p ANTXR2 -0.31 0.3708 0.45 0.35344 PITA -0.51 0 NA
24 hsa-miR-125a-5p ANXA11 -0.31 0.3708 0.21 0.52584 mirMAP -0.38 0 NA
25 hsa-miR-125a-5p APOD -0.31 0.3708 0.71 0.376 miRanda -0.44 0.01111 NA
26 hsa-miR-125a-5p ARHGAP11B -0.31 0.3708 0.43 0.4759 miRanda -0.3 0.02232 NA
27 hsa-miR-125a-5p ARHGAP27 -0.31 0.3708 0.33 0.47834 miRanda -0.4 0.0001 NA
28 hsa-miR-125a-5p ARHGEF2 -0.31 0.3708 0.01 0.98121 miRanda -0.29 2.0E-5 NA
29 hsa-miR-125a-5p ARMC7 -0.31 0.3708 0.14 0.58061 MirTarget; miRanda -0.14 0.00867 NA
30 hsa-miR-125a-5p ARPC5 -0.31 0.3708 -0.13 0.53299 miRNAWalker2 validate -0.11 0.01232 NA
31 hsa-miR-125a-5p ARSD -0.31 0.3708 0.54 0.1225 miRanda -0.2 0.00707 NA
32 hsa-miR-125a-5p ARSI -0.31 0.3708 -0.05 0.95343 MirTarget; miRanda -0.58 0.0005 NA
33 hsa-miR-125a-5p ASPH -0.31 0.3708 0.98 0.03201 miRanda -0.37 0.00021 NA
34 hsa-miR-125a-5p ATL2 -0.31 0.3708 -0 0.9982 miRNAWalker2 validate; miRanda -0.11 0.03608 NA
35 hsa-miR-125a-5p B2M -0.31 0.3708 -0.36 0.22342 miRanda -0.2 0.0024 NA
36 hsa-miR-125a-5p B3GALNT2 -0.31 0.3708 0.28 0.24769 MirTarget; miRanda; miRNATAP -0.13 0.01209 NA
37 hsa-miR-125a-5p B3GNT3 -0.31 0.3708 4.44 0 MirTarget -0.81 1.0E-5 NA
38 hsa-miR-125a-5p B3GNT7 -0.31 0.3708 0.91 0.22431 mirMAP -0.73 1.0E-5 NA
39 hsa-miR-125a-5p B4GALT1 -0.31 0.3708 -0.2 0.59693 miRanda -0.47 0 NA
40 hsa-miR-125a-5p BAK1 -0.31 0.3708 0.35 0.26822 miRNAWalker2 validate; PITA; miRanda; miRNATAP -0.39 0 NA
41 hsa-miR-125a-5p BATF2 -0.31 0.3708 0 0.99425 miRanda -0.21 0.04307 NA
42 hsa-miR-125a-5p BAZ1A -0.31 0.3708 -0.22 0.53161 miRanda -0.33 1.0E-5 NA
43 hsa-miR-125a-5p BCAT1 -0.31 0.3708 -0.37 0.61191 MirTarget -0.43 0.00705 NA
44 hsa-miR-125a-5p BCKDK -0.31 0.3708 -0.01 0.94665 miRanda -0.15 0.00057 NA
45 hsa-miR-125a-5p BCL2L12 -0.31 0.3708 -0.07 0.87268 miRanda; miRNATAP -0.51 0 NA
46 hsa-miR-125a-5p BCL2L14 -0.31 0.3708 1.55 0.10771 MirTarget; PITA; miRanda -1.31 0 NA
47 hsa-miR-125a-5p BIK -0.31 0.3708 0.91 0.17202 miRanda -0.48 0.00101 NA
48 hsa-miR-125a-5p BLZF1 -0.31 0.3708 0.7 0.01024 miRanda -0.15 0.01388 NA
49 hsa-miR-125a-5p BMP1 -0.31 0.3708 -0.01 0.9761 mirMAP -0.19 0.03832 NA
50 hsa-miR-125a-5p BMPR1B -0.31 0.3708 0.22 0.768 MirTarget; miRNATAP -0.92 0 NA
51 hsa-miR-125a-5p BRCC3 -0.31 0.3708 0.28 0.1857 miRanda -0.1 0.02579 NA
52 hsa-miR-125a-5p BTN2A2 -0.31 0.3708 -1.12 0.00207 miRanda -0.25 0.00172 NA
53 hsa-miR-125a-5p C1RL -0.31 0.3708 -0.35 0.31475 miRanda -0.34 0 NA
54 hsa-miR-125a-5p C2 -0.31 0.3708 -0.78 0.18449 miRanda -0.61 0 NA
55 hsa-miR-125a-5p CANT1 -0.31 0.3708 0.64 0.0479 mirMAP -0.36 0 NA
56 hsa-miR-125a-5p CASP10 -0.31 0.3708 -0.18 0.62889 mirMAP -0.33 2.0E-5 NA
57 hsa-miR-125a-5p CASP6 -0.31 0.3708 0.22 0.45531 miRanda -0.34 0 NA
58 hsa-miR-125a-5p CBLB -0.31 0.3708 -0.33 0.19169 miRanda -0.19 0.00051 NA
59 hsa-miR-125a-5p CCT2 -0.31 0.3708 0.18 0.4333 miRanda -0.12 0.01365 NA
60 hsa-miR-125a-5p CD248 -0.31 0.3708 0.06 0.91415 PITA; miRanda; miRNATAP -0.3 0.01514 NA
61 hsa-miR-125a-5p CD276 -0.31 0.3708 -0.03 0.92101 miRanda -0.27 0.00013 NA
62 hsa-miR-125a-5p CD300LF -0.31 0.3708 -1.89 0.00608 miRNATAP -0.3 0.0488 NA
63 hsa-miR-125a-5p CDA -0.31 0.3708 1.34 0.11216 miRanda -0.54 0.00357 NA
64 hsa-miR-125a-5p CDKN1A -0.31 0.3708 0.47 0.17186 miRNAWalker2 validate; miRTarBase -0.29 9.0E-5 NA
65 hsa-miR-125a-5p CDR2L -0.31 0.3708 1.26 0.00688 MirTarget; PITA; miRanda -0.53 0 NA
66 hsa-miR-125a-5p CDRT1 -0.31 0.3708 0.11 0.89138 miRanda -0.46 0.01223 NA
67 hsa-miR-125a-5p CENPO -0.31 0.3708 0.26 0.36646 mirMAP -0.2 0.00154 NA
68 hsa-miR-125a-5p CFLAR -0.31 0.3708 -0.19 0.52443 miRanda -0.23 0.00048 NA
69 hsa-miR-125a-5p CGN -0.31 0.3708 2.9 0 MirTarget; PITA; miRanda -0.5 0.00033 NA
70 hsa-miR-125a-5p CGNL1 -0.31 0.3708 -0.04 0.94148 miRNAWalker2 validate; miRanda -0.21 0.0471 NA
71 hsa-miR-125a-5p CGREF1 -0.31 0.3708 1.32 0.01456 MirTarget; miRanda -0.47 5.0E-5 NA
72 hsa-miR-125a-5p CHRM3 -0.31 0.3708 0.71 0.41825 miRanda -0.38 0.04404 NA
73 hsa-miR-125a-5p CIAPIN1 -0.31 0.3708 0.1 0.5024 MirTarget -0.15 0 NA
74 hsa-miR-125a-5p CKLF -0.31 0.3708 0.49 0.17116 miRanda -0.26 0.00083 NA
75 hsa-miR-125a-5p CKS1B -0.31 0.3708 0.99 0.01468 miRanda -0.4 0 NA
76 hsa-miR-125a-5p CLDN12 -0.31 0.3708 1.23 0.00105 miRNAWalker2 validate -0.19 0.02444 NA
77 hsa-miR-125a-5p CLDN2 -0.31 0.3708 3.07 0.03172 miRanda -1.24 6.0E-5 NA
78 hsa-miR-125a-5p CLEC2B -0.31 0.3708 -0.85 0.07347 miRanda -0.33 0.00143 NA
79 hsa-miR-125a-5p CLN6 -0.31 0.3708 0.16 0.5387 MirTarget; miRanda -0.18 0.00151 NA
80 hsa-miR-125a-5p COL1A2 -0.31 0.3708 0.25 0.73723 miRanda -0.49 0.00245 NA
81 hsa-miR-125a-5p COMT -0.31 0.3708 0.24 0.34273 mirMAP -0.18 0.00146 NA
82 hsa-miR-125a-5p COQ9 -0.31 0.3708 0.33 0.09125 miRanda -0.12 0.00402 NA
83 hsa-miR-125a-5p CORO1C -0.31 0.3708 -0.17 0.56501 miRNAWalker2 validate -0.26 6.0E-5 NA
84 hsa-miR-125a-5p CORO2A -0.31 0.3708 1.63 0.00807 MirTarget; miRanda -0.64 0 NA
85 hsa-miR-125a-5p CRK -0.31 0.3708 0.06 0.82262 miRNAWalker2 validate -0.19 0.00052 NA
86 hsa-miR-125a-5p CTH -0.31 0.3708 0.72 0.13195 miRanda -0.4 0.00013 NA
87 hsa-miR-125a-5p CTNNB1 -0.31 0.3708 0.1 0.66553 miRanda -0.22 1.0E-5 NA
88 hsa-miR-125a-5p CYB5B -0.31 0.3708 0.29 0.23263 miRanda -0.25 0 NA
89 hsa-miR-125a-5p CYBA -0.31 0.3708 -0.45 0.42403 miRanda -0.25 0.04386 NA
90 hsa-miR-125a-5p CYTH1 -0.31 0.3708 -0.6 0.03112 MirTarget; miRNATAP -0.18 0.00256 NA
91 hsa-miR-125a-5p DECR1 -0.31 0.3708 -0.2 0.39831 miRanda -0.12 0.02219 NA
92 hsa-miR-125a-5p DERL3 -0.31 0.3708 0.43 0.47961 mirMAP -0.54 3.0E-5 NA
93 hsa-miR-125a-5p DGAT1 -0.31 0.3708 0.63 0.07983 miRNATAP -0.19 0.01562 NA
94 hsa-miR-125a-5p DHFR -0.31 0.3708 0.42 0.17675 miRanda -0.24 0.00051 NA
95 hsa-miR-125a-5p DIAPH3 -0.31 0.3708 1.01 0.0985 miRanda -0.74 0 NA
96 hsa-miR-125a-5p DNAJA4 -0.31 0.3708 1.17 0.00387 miRanda -0.18 0.04406 NA
97 hsa-miR-125a-5p DOK1 -0.31 0.3708 -0.67 0.01789 miRanda -0.2 0.00115 NA
98 hsa-miR-125a-5p DPH2 -0.31 0.3708 0.16 0.4742 MirTarget; miRanda; miRNATAP -0.23 0 NA
99 hsa-miR-125a-5p DQX1 -0.31 0.3708 3.41 0.01736 miRanda -1.09 0.0005 NA
100 hsa-miR-125a-5p DRAM2 -0.31 0.3708 -0.46 0.01352 MirTarget; miRanda; miRNATAP -0.14 0.00076 NA
101 hsa-miR-125a-5p DRP2 -0.31 0.3708 -0.24 0.77332 MirTarget -0.93 0 NA
102 hsa-miR-125a-5p DSG2 -0.31 0.3708 1.16 0.02127 MirTarget; miRanda -0.26 0.01732 NA
103 hsa-miR-125a-5p DSTN -0.31 0.3708 0.36 0.12781 miRanda -0.1 0.04433 NA
104 hsa-miR-125a-5p DTWD1 -0.31 0.3708 0.16 0.39374 miRanda -0.11 0.00725 NA
105 hsa-miR-125a-5p DTX4 -0.31 0.3708 0.43 0.27683 PITA; miRanda; mirMAP -0.28 0.00085 NA
106 hsa-miR-125a-5p E2F2 -0.31 0.3708 -0.19 0.7383 MirTarget -0.65 0 NA
107 hsa-miR-125a-5p E2F3 -0.31 0.3708 -0.2 0.50008 PITA; miRanda; miRNATAP -0.24 0.00025 NA
108 hsa-miR-125a-5p E2F7 -0.31 0.3708 0.87 0.2158 miRNAWalker2 validate -0.7 0 NA
109 hsa-miR-125a-5p EDEM1 -0.31 0.3708 -0.26 0.30183 MirTarget; miRanda -0.13 0.01766 NA
110 hsa-miR-125a-5p EEF1A1 -0.31 0.3708 -0.16 0.52217 miRNAWalker2 validate -0.12 0.0268 NA
111 hsa-miR-125a-5p EGFR -0.31 0.3708 0.65 0.25306 mirMAP -0.39 0.00158 19881956; 27094723; 24484870 We report that EGFR signaling leads to transcriptional repression of the miRNA miR-125a through the ETS family transcription factor PEA3;Suppression of microRNA 125a 5p upregulates the TAZ EGFR signaling pathway and promotes retinoblastoma proliferation; Moreover the overexpression of miR-125a-5p led to a decrease in TAZ expression and downstream EGFR signaling pathway activation both in vitro and vivo; Finally TAZ overexpression in retinoblastoma cells overexpressing miR-125a-5p restored retinoblastoma cell proliferation and EGFR pathway activation; Taken together our data demonstrated that miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma;miR 125a regulates cell cycle proliferation and apoptosis by targeting the ErbB pathway in acute myeloid leukemia; Profiling revealed the ErbB pathway as significantly decreased with ectopic miR-125a; Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic agents for treating miR-125a-low AML
112 hsa-miR-125a-5p EIF4E2 -0.31 0.3708 -0 0.99795 miRanda -0.2 0 NA
113 hsa-miR-125a-5p EIF4EBP1 -0.31 0.3708 0.24 0.58363 miRNAWalker2 validate; MirTarget; miRanda; miRNATAP -0.4 3.0E-5 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression
114 hsa-miR-125a-5p ELF4 -0.31 0.3708 0.21 0.52016 miRanda -0.14 0.048 NA
115 hsa-miR-125a-5p ELK1 -0.31 0.3708 -0.04 0.80683 miRanda -0.12 0.00195 NA
116 hsa-miR-125a-5p ELOVL1 -0.31 0.3708 0.24 0.3676 PITA; miRanda; miRNATAP -0.29 0 NA
117 hsa-miR-125a-5p ELOVL6 -0.31 0.3708 1.2 0.00783 MirTarget; PITA; miRanda -0.27 0.00743 NA
118 hsa-miR-125a-5p EME1 -0.31 0.3708 0.31 0.54499 miRanda -0.5 1.0E-5 NA
119 hsa-miR-125a-5p EMILIN2 -0.31 0.3708 -1 0.02 miRanda -0.39 3.0E-5 NA
120 hsa-miR-125a-5p EMX1 -0.31 0.3708 0.98 0.4315 mirMAP -0.55 0.04197 NA
121 hsa-miR-125a-5p ENO1 -0.31 0.3708 -0.04 0.91738 miRNAWalker2 validate -0.16 0.03791 NA
122 hsa-miR-125a-5p EPHA2 -0.31 0.3708 1.89 0.00763 miRanda -0.48 0.00204 NA
123 hsa-miR-125a-5p ERBB2 -0.31 0.3708 1 0.05532 miRNAWalker2 validate -0.53 0 21220473; 26966351 We investigated a tumor inhibitory effect of miR-125a-5p in gastric cancer focusing in particular on the miR-125a-ERBB2 HER2 HER-2/neu pathway; The regulation of ERBB2 by miR-125a-5p was examined with precursor miR-125a-transfected cells; Furthermore we investigated whether miR-125a-5p suppresses proliferation of gastric cancer cells in combination with trastuzumab a monoclonal antibody against ERBB2; In vitro assays showed that ERBB2 is a direct target of miR-125a-5p which potently suppressed the proliferation of gastric cancer cells and interestingly the growth inhibitory effect was enhanced in combination with trastuzumab;Moreover restoration of the expression of ErbB2 and glucose metabolic enzymes in miR-125 pretransfected cells recovered the susceptibility to doxorubicin
124 hsa-miR-125a-5p ERBB3 -0.31 0.3708 3.09 0 miRNAWalker2 validate; miRanda -0.38 0.01284 NA
125 hsa-miR-125a-5p ERGIC1 -0.31 0.3708 0.13 0.58748 miRanda -0.3 0 NA
126 hsa-miR-125a-5p ERMN -0.31 0.3708 -1.13 0.11865 miRanda -0.39 0.01395 NA
127 hsa-miR-125a-5p ESPL1 -0.31 0.3708 0.61 0.29955 miRanda -0.64 0 NA
128 hsa-miR-125a-5p ESRRA -0.31 0.3708 0.38 0.20411 MirTarget; PITA; miRanda; miRNATAP -0.16 0.01479 NA
129 hsa-miR-125a-5p ETV6 -0.31 0.3708 -0.18 0.40743 MirTarget; PITA; miRanda; miRNATAP -0.22 0 NA
130 hsa-miR-125a-5p FAM107B -0.31 0.3708 -0.22 0.53649 MirTarget; miRNATAP -0.33 2.0E-5 NA
131 hsa-miR-125a-5p FAM129B -0.31 0.3708 0.58 0.08463 mirMAP; miRNATAP -0.26 0.00039 NA
132 hsa-miR-125a-5p FAM89B -0.31 0.3708 -0.18 0.50185 miRanda -0.13 0.02361 NA
133 hsa-miR-125a-5p FANCI -0.31 0.3708 0.67 0.08377 miRanda -0.39 0 NA
134 hsa-miR-125a-5p FBXO45 -0.31 0.3708 0.34 0.08542 PITA; miRanda -0.1 0.01828 NA
135 hsa-miR-125a-5p FEN1 -0.31 0.3708 0.44 0.13502 miRanda -0.2 0.00188 NA
136 hsa-miR-125a-5p FERMT1 -0.31 0.3708 2.37 0.00699 miRNAWalker2 validate -0.99 0 NA
137 hsa-miR-125a-5p FGFR2 -0.31 0.3708 0.43 0.59217 miRanda; miRNATAP -0.91 0 NA
138 hsa-miR-125a-5p FLVCR2 -0.31 0.3708 -0.93 0.09133 miRanda -0.25 0.04024 NA
139 hsa-miR-125a-5p FNDC3B -0.31 0.3708 0.21 0.56856 PITA; miRanda -0.25 0.00195 NA
140 hsa-miR-125a-5p FOSL2 -0.31 0.3708 0.14 0.73953 mirMAP -0.41 0 NA
141 hsa-miR-125a-5p FOXD2 -0.31 0.3708 0.95 0.09797 PITA; miRanda -0.36 0.00394 NA
142 hsa-miR-125a-5p FRAT2 -0.31 0.3708 -0.12 0.73257 miRanda -0.39 0 NA
143 hsa-miR-125a-5p FUT3 -0.31 0.3708 2.52 0.02436 miRanda -1.36 0 NA
144 hsa-miR-125a-5p FUT4 -0.31 0.3708 -0.09 0.82434 MirTarget; PITA; miRanda; miRNATAP -0.49 0 NA
145 hsa-miR-125a-5p GABRP -0.31 0.3708 2.11 0.18072 miRanda -1.69 0 NA
146 hsa-miR-125a-5p GALNT7 -0.31 0.3708 0.48 0.32277 MirTarget; PITA; miRanda -0.43 3.0E-5 NA
147 hsa-miR-125a-5p GATA6 -0.31 0.3708 0.17 0.70487 miRanda -0.29 0.00234 NA
148 hsa-miR-125a-5p GBP2 -0.31 0.3708 -0.09 0.83938 miRanda -0.5 0 NA
149 hsa-miR-125a-5p GCOM1 -0.31 0.3708 -0.62 0.39818 miRanda -0.57 0.0004 NA
150 hsa-miR-125a-5p GGCT -0.31 0.3708 0.41 0.10503 miRNAWalker2 validate -0.29 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 TISSUE DEVELOPMENT 62 1518 1.192e-06 0.005547
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 ANCHORING JUNCTION 30 489 3.975e-07 0.0002322
2 CELL SUBSTRATE JUNCTION 24 398 7.819e-06 0.002283

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04012_ErbB_signaling_pathway 8 87 0.0006214 0.1119
2 hsa04510_Focal_adhesion 12 200 0.001522 0.1291
3 hsa00601_Glycosphingolipid_biosynthesis_._lacto_and_neolacto_series 4 26 0.002277 0.1291
4 hsa03050_Proteasome 5 45 0.002869 0.1291
5 hsa00520_Amino_sugar_and_nucleotide_sugar_metabolism 5 48 0.003813 0.1327
6 hsa00480_Glutathione_metabolism 5 50 0.004554 0.1327
7 hsa04520_Adherens_junction 6 73 0.005159 0.1327
8 hsa00051_Fructose_and_mannose_metabolism 4 36 0.007561 0.1701
9 hsa00010_Glycolysis_._Gluconeogenesis 5 65 0.01363 0.2295
10 hsa04144_Endocytosis 10 203 0.01389 0.2295
11 hsa04670_Leukocyte_transendothelial_migration 7 117 0.01424 0.2295
12 hsa04020_Calcium_signaling_pathway 9 177 0.01584 0.2295
13 hsa04320_Dorso.ventral_axis_formation 3 25 0.01658 0.2295
14 hsa04720_Long.term_potentiation 5 70 0.0183 0.2321
15 hsa04722_Neurotrophin_signaling_pathway 7 127 0.02139 0.2321
16 hsa04110_Cell_cycle 7 128 0.02221 0.2321
17 hsa04151_PI3K_AKT_signaling_pathway 14 351 0.02252 0.2321
18 hsa04912_GnRH_signaling_pathway 6 101 0.02321 0.2321
19 hsa04612_Antigen_processing_and_presentation 5 78 0.02776 0.263
20 hsa04910_Insulin_signaling_pathway 7 138 0.03176 0.2858
21 hsa00562_Inositol_phosphate_metabolism 4 57 0.03557 0.3049
22 hsa00533_Glycosaminoglycan_biosynthesis_._keratan_sulfate 2 15 0.04128 0.3378
23 hsa04210_Apoptosis 5 89 0.04511 0.3418
24 hsa04810_Regulation_of_actin_cytoskeleton 9 214 0.04557 0.3418
25 hsa00350_Tyrosine_metabolism 3 41 0.05965 0.4295
26 hsa00240_Pyrimidine_metabolism 5 99 0.06545 0.4531
27 hsa04014_Ras_signaling_pathway 9 236 0.07453 0.4876
28 hsa04971_Gastric_acid_secretion 4 74 0.07814 0.4876
29 hsa00514_Other_types_of_O.glycan_biosynthesis 3 46 0.07856 0.4876
30 hsa04330_Notch_signaling_pathway 3 47 0.08262 0.4957
31 hsa04070_Phosphatidylinositol_signaling_system 4 78 0.09071 0.5267
32 hsa04114_Oocyte_meiosis 5 114 0.1041 0.5684
33 hsa04150_mTOR_signaling_pathway 3 52 0.1042 0.5684
34 hsa04512_ECM.receptor_interaction 4 85 0.1148 0.5994
35 hsa00052_Galactose_metabolism 2 27 0.1166 0.5994
36 hsa04390_Hippo_signaling_pathway 6 154 0.1211 0.6053
37 hsa04970_Salivary_secretion 4 89 0.1298 0.6167
38 hsa04010_MAPK_signaling_pathway 9 268 0.1332 0.6167
39 hsa04540_Gap_junction 4 90 0.1336 0.6167
40 hsa04141_Protein_processing_in_endoplasmic_reticulum 6 168 0.1617 0.7267
41 hsa04530_Tight_junction 5 133 0.1655 0.7267
42 hsa04972_Pancreatic_secretion 4 101 0.1788 0.7665
43 hsa04115_p53_signaling_pathway 3 69 0.1906 0.7978
44 hsa00980_Metabolism_of_xenobiotics_by_cytochrome_P450 3 71 0.2017 0.8076
45 hsa00982_Drug_metabolism_._cytochrome_P450 3 73 0.213 0.8076
46 hsa04310_Wnt_signaling_pathway 5 151 0.234 0.8595
47 hsa04270_Vascular_smooth_muscle_contraction 4 116 0.2472 0.8802
48 hsa04630_Jak.STAT_signaling_pathway 5 155 0.2502 0.8802
49 hsa04145_Phagosome 5 156 0.2543 0.8802
50 hsa04350_TGF.beta_signaling_pathway 3 85 0.2831 0.9264
51 hsa00561_Glycerolipid_metabolism 2 50 0.2977 0.9378
52 hsa03010_Ribosome 3 92 0.3248 0.9511
53 hsa04666_Fc_gamma_R.mediated_phagocytosis 3 95 0.3428 0.9696
54 hsa04514_Cell_adhesion_molecules_.CAMs. 4 136 0.3447 0.9696
55 hsa04916_Melanogenesis 3 101 0.3785 1
56 hsa00830_Retinol_metabolism 2 64 0.4082 1
57 hsa03013_RNA_transport 4 152 0.4237 1
58 hsa04610_Complement_and_coagulation_cascades 2 69 0.4457 1
59 hsa04730_Long.term_depression 2 70 0.4531 1
60 hsa00230_Purine_metabolism 4 162 0.4719 1
61 hsa04142_Lysosome 3 121 0.4932 1
62 hsa04974_Protein_digestion_and_absorption 2 81 0.5299 1
63 hsa03040_Spliceosome 3 128 0.5309 1
64 hsa04360_Axon_guidance 3 130 0.5414 1
65 hsa04640_Hematopoietic_cell_lineage 2 88 0.5749 1
66 hsa04120_Ubiquitin_mediated_proteolysis 3 139 0.5868 1
67 hsa04660_T_cell_receptor_signaling_pathway 2 108 0.6856 1
68 hsa04380_Osteoclast_differentiation 2 128 0.7716 1
69 hsa04062_Chemokine_signaling_pathway 3 189 0.7836 1
70 hsa04650_Natural_killer_cell_mediated_cytotoxicity 2 136 0.7998 1

Quest ID: 5e6e40964cd71b7bf0b9011d16d641df