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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-141-3p PTEN 0.09 0.71333 -0.14 0.7904 miRNAWalker2 validate; miRTarBase; TargetScan; miRNATAP -1.13 0.00135 24742567; 24742567 3 In typeIEC loss of PTEN was more frequent in the miR-141 or miR-200a up-regulated subgroups and the correlation between the PTEN and miR-200a status in typeItumors was statistically significant P < 0.05;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis
2 hsa-miR-494-3p PTEN 0.06 0.80597 -0.14 0.7904 miRNAWalker2 validate; miRTarBase; MirTarget -0.84 0
3 hsa-miR-130b-3p PTEN 0.13 0.49341 -0.14 0.7904 MirTarget; miRNATAP -0.52 0.00408
4 hsa-miR-188-5p PTEN 0.06 0.76468 -0.14 0.7904 MirTarget; PITA; miRNATAP -0.84 0
5 hsa-miR-198 PTEN 0.16 0.35856 -0.14 0.7904 MirTarget; PITA -0.22 0.00928
6 hsa-miR-30d-3p PTEN 0.01 0.9725 -0.14 0.7904 MirTarget; miRNATAP -0.38 0.00067
7 hsa-miR-486-5p PTEN 0.15 0.41299 -0.14 0.7904 MirTarget; PITA; miRanda; miRNATAP -0.32 0.00093
8 hsa-miR-92a-3p PTEN 0.03 0.87892 -0.14 0.7904 MirTarget; miRNATAP -0.9 0.012
9 hsa-miR-92b-3p PTEN -0.24 0.11056 -0.14 0.7904 MirTarget; miRNATAP -0.24 0.00079 24099768 Furthermore we found miR-92b could directly target PTEN a unique tumor suppressor gene which was downregulated in lung cancer tissues compared to the matched adjacent normal tissues
10 hsa-miR-548c-3p PTEN 1.21 3.0E-5 -0.14 0.7904 PITA; mirMAP -0.07 0.00185
11 hsa-miR-548c-5p PTEN -0.16 0.33949 -0.14 0.7904 PITA; mirMAP -0.15 0.02878
12 hsa-miR-622 PTEN 0.18 0.33128 -0.14 0.7904 PITA; miRNATAP -0.43 2.0E-5
13 hsa-miR-631 PTEN -0.08 0.66864 -0.14 0.7904 PITA -0.26 0.00251
14 hsa-miR-125a-3p PTEN 0.04 0.82854 -0.14 0.7904 miRanda -0.52 0.00031
15 hsa-let-7b-3p PTEN -0.25 0.19025 -0.14 0.7904 mirMAP -0.14 0.02364
16 hsa-let-7f-1-3p PTEN -0.3 0.11053 -0.14 0.7904 mirMAP -0.11 0.03798
17 hsa-miR-150-3p PTEN 0.14 0.49139 -0.14 0.7904 mirMAP -0.65 0.0001
18 hsa-miR-300 PTEN -0.31 0.12146 -0.14 0.7904 mirMAP -0.08 0.02894
19 hsa-miR-30d-5p PTEN 0.01 0.98104 -0.14 0.7904 mirMAP -0.93 0.00733

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 TUG1 hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-150-3p;hsa-miR-188-5p;hsa-miR-198;hsa-miR-300;hsa-miR-30d-3p;hsa-miR-494-3p;hsa-miR-548c-3p;hsa-miR-548c-5p;hsa-miR-622;hsa-miR-92a-3p;hsa-miR-92b-3p 16 PTEN Sponge network -0.082 0.89719 -0.138 0.7904 0.753
2 RP11-819C21.1 hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-150-3p;hsa-miR-188-5p;hsa-miR-198;hsa-miR-30d-3p;hsa-miR-30d-5p;hsa-miR-548c-3p;hsa-miR-548c-5p;hsa-miR-622 11 PTEN Sponge network -0.347 0.44227 -0.138 0.7904 0.723
3 AC009948.5 hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-150-3p;hsa-miR-188-5p;hsa-miR-198;hsa-miR-30d-3p;hsa-miR-30d-5p;hsa-miR-486-5p;hsa-miR-494-3p;hsa-miR-548c-3p;hsa-miR-622 12 PTEN Sponge network -0.28 0.49856 -0.138 0.7904 0.625
4 LINC00641 hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-125a-3p;hsa-miR-141-3p;hsa-miR-150-3p;hsa-miR-188-5p;hsa-miR-198;hsa-miR-300;hsa-miR-30d-3p;hsa-miR-486-5p;hsa-miR-494-3p;hsa-miR-548c-3p;hsa-miR-548c-5p 13 PTEN Sponge network -0.08 0.86867 -0.138 0.7904 0.578
5 CTC-428H11.2 hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-150-3p;hsa-miR-30d-5p;hsa-miR-494-3p;hsa-miR-548c-3p;hsa-miR-622;hsa-miR-92a-3p;hsa-miR-92b-3p 10 PTEN Sponge network -0.099 0.84364 -0.138 0.7904 0.551
6 RP11-890B15.3 hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-150-3p;hsa-miR-188-5p;hsa-miR-198;hsa-miR-30d-3p;hsa-miR-494-3p;hsa-miR-548c-3p;hsa-miR-622 10 PTEN Sponge network -0.392 0.44544 -0.138 0.7904 0.525
7 AF131217.1 hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-150-3p;hsa-miR-188-5p;hsa-miR-198;hsa-miR-30d-3p;hsa-miR-30d-5p;hsa-miR-486-5p;hsa-miR-548c-3p 10 PTEN Sponge network -1.152 0.01238 -0.138 0.7904 0.487
8 RP11-88I18.2 hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-150-3p;hsa-miR-188-5p;hsa-miR-30d-3p;hsa-miR-30d-5p;hsa-miR-486-5p;hsa-miR-494-3p;hsa-miR-548c-3p;hsa-miR-622;hsa-miR-92a-3p 11 PTEN Sponge network -0.08 0.88027 -0.138 0.7904 0.478
9 NNT-AS1 hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-150-3p;hsa-miR-188-5p;hsa-miR-198;hsa-miR-30d-5p;hsa-miR-486-5p;hsa-miR-494-3p;hsa-miR-548c-3p;hsa-miR-622 11 PTEN Sponge network -0.272 0.46308 -0.138 0.7904 0.447
10 RP11-138A9.1 hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-150-3p;hsa-miR-198;hsa-miR-30d-3p;hsa-miR-30d-5p;hsa-miR-494-3p;hsa-miR-548c-3p;hsa-miR-622 10 PTEN Sponge network -0.222 0.69145 -0.138 0.7904 0.443
11 TPT1-AS1 hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-150-3p;hsa-miR-188-5p;hsa-miR-198;hsa-miR-30d-3p;hsa-miR-30d-5p;hsa-miR-486-5p;hsa-miR-494-3p;hsa-miR-622;hsa-miR-92a-3p 12 PTEN Sponge network -0.231 0.62115 -0.138 0.7904 0.435
12 FENDRR hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-150-3p;hsa-miR-188-5p;hsa-miR-30d-3p;hsa-miR-30d-5p;hsa-miR-486-5p;hsa-miR-494-3p;hsa-miR-548c-3p;hsa-miR-622 11 PTEN Sponge network -0.607 0.19262 -0.138 0.7904 0.391
13 ADAMTS9-AS2 hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-150-3p;hsa-miR-188-5p;hsa-miR-30d-3p;hsa-miR-30d-5p;hsa-miR-494-3p;hsa-miR-548c-3p;hsa-miR-622;hsa-miR-92a-3p 11 PTEN Sponge network -0.731 0.12937 -0.138 0.7904 0.357
14 RP11-166D19.1 hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-150-3p;hsa-miR-188-5p;hsa-miR-30d-3p;hsa-miR-494-3p;hsa-miR-548c-3p;hsa-miR-622;hsa-miR-92a-3p 10 PTEN Sponge network -0.287 0.4855 -0.138 0.7904 0.343
15 MIR143HG hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-150-3p;hsa-miR-188-5p;hsa-miR-30d-3p;hsa-miR-30d-5p;hsa-miR-486-5p;hsa-miR-548c-3p;hsa-miR-622;hsa-miR-92a-3p 11 PTEN Sponge network -0.809 0.12694 -0.138 0.7904 0.296

Quest ID: 5e864e202e3396890844ebbe3f7560dd