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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-342-3p AACS 1.41 0 -0.76 0 miRanda -0.23 0 NA
2 hsa-miR-342-3p AASDH 1.41 0 -0.66 0 miRanda -0.21 0 NA
3 hsa-miR-342-3p ABCA13 1.41 0 -4.45 0 miRanda -1.22 0 NA
4 hsa-miR-342-3p ABCA6 1.41 0 -1.98 0 miRanda -0.26 0.00995 NA
5 hsa-miR-342-3p ABI2 1.41 0 -0.56 0 miRanda -0.17 0 NA
6 hsa-miR-342-3p ACAD10 1.41 0 -0.75 0 miRanda -0.22 0 NA
7 hsa-miR-342-3p ACSL3 1.41 0 -1.02 0 miRanda -0.26 0 NA
8 hsa-miR-342-3p ACSL4 1.41 0 -1.51 0 MirTarget; miRanda -0.24 0 NA
9 hsa-miR-342-3p ACTR3B 1.41 0 -0.64 0 miRanda -0.2 0 NA
10 hsa-miR-342-3p ACVR1B 1.41 0 -0.98 0 MirTarget; PITA; mirMAP -0.32 0 NA
11 hsa-miR-342-3p ADAMTS15 1.41 0 -2.45 0 mirMAP -0.63 0 NA
12 hsa-miR-342-3p ADAMTS17 1.41 0 -0.35 0.00856 miRanda -0.23 2.0E-5 NA
13 hsa-miR-342-3p ADAMTS19 1.41 0 -4.42 0 miRanda -0.69 0 NA
14 hsa-miR-342-3p ADAMTS6 1.41 0 -0.86 0 miRanda -0.15 0.01813 NA
15 hsa-miR-342-3p ADAMTS8 1.41 0 -1.9 0 miRanda -0.56 0 NA
16 hsa-miR-342-3p ADH1B 1.41 0 -4.41 0 miRanda -1.02 0 NA
17 hsa-miR-342-3p ADHFE1 1.41 0 -1.56 0 miRanda -0.6 0 NA
18 hsa-miR-342-3p ADI1 1.41 0 -0.89 0 miRanda -0.15 0.0002 NA
19 hsa-miR-342-3p ADPRHL1 1.41 0 -1.66 0 miRanda -0.53 0 NA
20 hsa-miR-342-3p ADRA2B 1.41 0 0.11 0.52307 miRanda -0.16 0.01254 NA
21 hsa-miR-342-3p ADRB1 1.41 0 -3.15 0 PITA; miRanda -0.86 0 NA
22 hsa-miR-342-3p AFMID 1.41 0 -1.22 0 miRanda -0.26 0 NA
23 hsa-miR-342-3p AGPAT4 1.41 0 -0.76 0 MirTarget -0.2 0 NA
24 hsa-miR-342-3p AGR2 1.41 0 -6.87 0 miRanda -1.57 0 NA
25 hsa-miR-342-3p AK5 1.41 0 -2.09 0 miRanda -0.29 0.00253 NA
26 hsa-miR-342-3p AKAP11 1.41 0 -0.48 0 miRanda -0.13 2.0E-5 NA
27 hsa-miR-342-3p AKAP9 1.41 0 -0.83 0 miRanda -0.31 0 NA
28 hsa-miR-342-3p AKIRIN1 1.41 0 -1.18 0 miRanda -0.28 0 NA
29 hsa-miR-342-3p AKR1B1 1.41 0 -0.02 0.89657 miRanda -0.14 0.04618 NA
30 hsa-miR-342-3p AKT2 1.41 0 -0.34 0 mirMAP -0.19 0 NA
31 hsa-miR-342-3p ALDH5A1 1.41 0 -1.16 0 miRanda -0.28 0 NA
32 hsa-miR-342-3p ALS2CL 1.41 0 -2.52 0 mirMAP -0.75 0 NA
33 hsa-miR-342-3p AMOT 1.41 0 -0.58 0 miRanda -0.19 3.0E-5 NA
34 hsa-miR-342-3p ANGPTL1 1.41 0 -4.05 0 miRanda -1.09 0 NA
35 hsa-miR-342-3p ANK2 1.41 0 -2.68 0 miRanda; miRNATAP -0.5 0 NA
36 hsa-miR-342-3p ANKRD17 1.41 0 -0.5 0 miRanda; miRNATAP -0.15 0 NA
37 hsa-miR-342-3p ANKRD52 1.41 0 -0.53 0 PITA; miRNATAP -0.14 0 NA
38 hsa-miR-342-3p AP1M2 1.41 0 -3.32 0 miRanda -0.95 0 NA
39 hsa-miR-342-3p AP2A2 1.41 0 -0.43 0 miRanda -0.12 0 NA
40 hsa-miR-342-3p AQP4 1.41 0 -1.93 0 miRanda -0.56 0 NA
41 hsa-miR-342-3p ARAF 1.41 0 -0.28 0 miRanda -0.1 0 NA
42 hsa-miR-342-3p ARHGEF10L 1.41 0 -0.45 0 miRanda -0.21 0 NA
43 hsa-miR-342-3p ARHGEF9 1.41 0 -0.41 0 miRanda -0.13 0 NA
44 hsa-miR-342-3p ARID1B 1.41 0 -0.52 0 MirTarget; PITA; miRanda; miRNATAP -0.16 0 NA
45 hsa-miR-342-3p ARIH2 1.41 0 -0.48 0 miRNAWalker2 validate -0.18 0 NA
46 hsa-miR-342-3p ARMC8 1.41 0 -0.39 0 PITA; miRanda -0.11 0 NA
47 hsa-miR-342-3p ARMCX3 1.41 0 -0.35 0 miRanda -0.14 0 NA
48 hsa-miR-342-3p ASAH1 1.41 0 -0.8 0 miRanda -0.17 2.0E-5 NA
49 hsa-miR-342-3p ASB1 1.41 0 -0.64 0 mirMAP -0.24 0 NA
50 hsa-miR-342-3p ASB5 1.41 0 -4.11 0 miRanda -1.08 0 NA
51 hsa-miR-342-3p ASTN1 1.41 0 -2.08 0 miRanda -0.54 1.0E-5 NA
52 hsa-miR-342-3p ATE1 1.41 0 -1.16 0 miRanda -0.33 0 NA
53 hsa-miR-342-3p ATF3 1.41 0 -1.24 0 miRanda -0.44 0 NA
54 hsa-miR-342-3p ATP10B 1.41 0 -2.67 0 miRanda -0.74 0 NA
55 hsa-miR-342-3p ATP10D 1.41 0 -0.6 0 miRanda -0.23 0 NA
56 hsa-miR-342-3p ATP6AP1 1.41 0 -0.25 0 miRanda -0.13 0 NA
57 hsa-miR-342-3p ATP6V0B 1.41 0 -0.8 0 miRanda -0.22 0 NA
58 hsa-miR-342-3p ATP6V1B1 1.41 0 -7.18 0 miRanda -2.12 0 NA
59 hsa-miR-342-3p ATP6V1G3 1.41 0 -8.9 0 miRanda -2.34 0 NA
60 hsa-miR-342-3p ATP9A 1.41 0 -1.26 0 miRanda -0.36 0 NA
61 hsa-miR-342-3p ATRNL1 1.41 0 -3.65 0 miRanda -0.95 0 NA
62 hsa-miR-342-3p ATXN1L 1.41 0 -0.53 0 miRNATAP -0.18 0 NA
63 hsa-miR-342-3p B3GNT3 1.41 0 -0.74 0.01334 miRanda -0.27 0.02376 NA
64 hsa-miR-342-3p B4GALNT2 1.41 0 -5.45 0 miRanda -1.76 0 NA
65 hsa-miR-342-3p BCKDHB 1.41 0 -1.39 0 miRanda -0.46 0 NA
66 hsa-miR-342-3p BCL2L10 1.41 0 -2.9 0 miRanda -0.91 0 NA
67 hsa-miR-342-3p BCL2L2 1.41 0 -0.65 0 miRanda -0.29 0 NA
68 hsa-miR-342-3p BDH2 1.41 0 -0.96 0 miRanda -0.29 0 NA
69 hsa-miR-342-3p BHLHB9 1.41 0 -1.22 0 miRanda -0.38 0 NA
70 hsa-miR-342-3p BMP7 1.41 0 -6.93 0 miRNAWalker2 validate; miRTarBase; miRanda -1.55 0 NA
71 hsa-miR-342-3p BNC1 1.41 0 -1.59 0 miRanda -0.3 0.02141 NA
72 hsa-miR-342-3p BRD3 1.41 0 -0.42 0 miRanda -0.12 0 NA
73 hsa-miR-342-3p BSN 1.41 0 -0.48 0.0005 miRanda; miRNATAP -0.24 1.0E-5 NA
74 hsa-miR-342-3p BTG3 1.41 0 -0.82 0 miRanda -0.17 0.00037 NA
75 hsa-miR-342-3p BTRC 1.41 0 -0.55 0 mirMAP -0.13 0 NA
76 hsa-miR-342-3p C17orf51 1.41 0 -1.03 0 mirMAP -0.2 1.0E-5 NA
77 hsa-miR-342-3p C1D 1.41 0 -0.4 0 miRanda -0.11 1.0E-5 NA
78 hsa-miR-342-3p C1orf115 1.41 0 -0.89 0 mirMAP -0.23 0 NA
79 hsa-miR-342-3p C2orf71 1.41 0 -4.86 0 mirMAP -0.8 0 NA
80 hsa-miR-342-3p CA12 1.41 0 -0.76 0 miRanda; miRNATAP -0.18 0.00394 NA
81 hsa-miR-342-3p CAB39L 1.41 0 -1.78 0 miRanda -0.65 0 NA
82 hsa-miR-342-3p CACNA1D 1.41 0 -0.61 0.00068 miRanda -0.36 0 NA
83 hsa-miR-342-3p CACNB4 1.41 0 -2.32 0 miRanda -0.52 0 NA
84 hsa-miR-342-3p CADM1 1.41 0 -1.47 0 PITA; miRanda -0.29 0 NA
85 hsa-miR-342-3p CALB1 1.41 0 -9.17 0 miRanda -1.83 0 NA
86 hsa-miR-342-3p CAMK2N1 1.41 0 -0.78 0 PITA; miRanda -0.27 0 NA
87 hsa-miR-342-3p CAPN13 1.41 0 -1.94 0 miRanda -0.72 0 NA
88 hsa-miR-342-3p CASC2 1.41 0 -1.29 0 miRanda -0.31 0 NA
89 hsa-miR-342-3p CBFA2T2 1.41 0 -0.12 0.03645 mirMAP -0.11 0 NA
90 hsa-miR-342-3p CBR4 1.41 0 -0.98 0 miRanda -0.29 0 NA
91 hsa-miR-342-3p CBX5 1.41 0 -0.37 0 mirMAP -0.13 0 NA
92 hsa-miR-342-3p CBX6 1.41 0 -0.74 0 mirMAP -0.29 0 NA
93 hsa-miR-342-3p CCDC149 1.41 0 -0.26 3.0E-5 miRanda -0.18 0 NA
94 hsa-miR-342-3p CCDC25 1.41 0 -0.64 0 MirTarget -0.18 0 NA
95 hsa-miR-342-3p CCDC28A 1.41 0 -0.39 0 miRanda -0.16 0 NA
96 hsa-miR-342-3p CCDC30 1.41 0 -0.53 0 miRanda -0.15 0.0001 NA
97 hsa-miR-342-3p CCDC66 1.41 0 -0.4 0 miRanda -0.1 0.00121 NA
98 hsa-miR-342-3p CCDC85C 1.41 0 -0.39 6.0E-5 miRanda -0.19 0 NA
99 hsa-miR-342-3p CCNG2 1.41 0 -0.27 0.00106 miRanda -0.2 0 NA
100 hsa-miR-342-3p CD2AP 1.41 0 -0.72 0 miRanda -0.18 0 NA
101 hsa-miR-342-3p CD55 1.41 0 -0.55 0 miRanda -0.16 4.0E-5 NA
102 hsa-miR-342-3p CD83 1.41 0 -1.04 0 miRanda -0.22 1.0E-5 NA
103 hsa-miR-342-3p CDADC1 1.41 0 -0.63 0 miRanda -0.22 0 NA
104 hsa-miR-342-3p CDC14A 1.41 0 -0.74 0 miRanda -0.16 0.00044 NA
105 hsa-miR-342-3p CDC42BPB 1.41 0 -0.41 0 miRanda -0.22 0 NA
106 hsa-miR-342-3p CDH1 1.41 0 -1.86 0 miRanda -0.72 0 NA
107 hsa-miR-342-3p CDH9 1.41 0 -3.21 0 miRanda -0.63 0.00021 NA
108 hsa-miR-342-3p CDKL2 1.41 0 -1.58 0 miRanda -0.64 0 NA
109 hsa-miR-342-3p CENPV 1.41 0 -1.27 0 miRanda -0.44 0 NA
110 hsa-miR-342-3p CEP78 1.41 0 -0.68 0 miRanda -0.16 0 NA
111 hsa-miR-342-3p CGNL1 1.41 0 -2.48 0 miRanda -0.68 0 NA
112 hsa-miR-342-3p CHCHD4 1.41 0 -0.7 0 miRanda -0.18 0 NA
113 hsa-miR-342-3p CHCHD7 1.41 0 -0.76 0 miRanda -0.24 0 NA
114 hsa-miR-342-3p CHD5 1.41 0 -3.64 0 mirMAP -1.29 0 NA
115 hsa-miR-342-3p CHL1 1.41 0 -5.04 0 miRanda -1.27 0 NA
116 hsa-miR-342-3p CHM 1.41 0 -0.54 0 miRanda -0.18 0 NA
117 hsa-miR-342-3p CHMP1B 1.41 0 -0.31 0 miRanda -0.14 0 NA
118 hsa-miR-342-3p CHODL 1.41 0 -3.22 0 miRanda -0.77 0 NA
119 hsa-miR-342-3p CHRDL1 1.41 0 -4.72 0 miRanda -0.69 0.00084 NA
120 hsa-miR-342-3p CHUK 1.41 0 -0.86 0 miRanda -0.19 0 NA
121 hsa-miR-342-3p CLCN5 1.41 0 -1.51 0 mirMAP -0.47 0 NA
122 hsa-miR-342-3p CLCNKA 1.41 0 -8.4 0 miRanda -2.3 0 NA
123 hsa-miR-342-3p CLCNKB 1.41 0 -8.57 0 miRanda -2.42 0 NA
124 hsa-miR-342-3p CLIC5 1.41 0 -3.27 0 miRanda -0.56 0 NA
125 hsa-miR-342-3p CLNK 1.41 0 -4.7 0 mirMAP -1.07 0 NA
126 hsa-miR-342-3p CLOCK 1.41 0 -0.82 0 PITA -0.2 0.00021 NA
127 hsa-miR-342-3p CLSTN2 1.41 0 -3.46 0 miRanda -0.73 0 NA
128 hsa-miR-342-3p CMTM4 1.41 0 -2.19 0 miRanda -0.8 0 NA
129 hsa-miR-342-3p CMYA5 1.41 0 -0.58 0.01441 miRanda -0.29 0.00192 NA
130 hsa-miR-342-3p CNNM2 1.41 0 -0.93 0 miRanda -0.28 0 NA
131 hsa-miR-342-3p COBL 1.41 0 -1.44 0 miRanda -0.58 0 NA
132 hsa-miR-342-3p COG2 1.41 0 -0.52 0 MirTarget; miRanda -0.11 0 NA
133 hsa-miR-342-3p COL4A6 1.41 0 -6.29 0 miRanda -1.71 0 NA
134 hsa-miR-342-3p COMMD8 1.41 0 -0.9 0 miRanda -0.17 0 NA
135 hsa-miR-342-3p COQ7 1.41 0 -0.28 0 miRanda -0.15 0 NA
136 hsa-miR-342-3p COX10 1.41 0 -0.57 0 miRanda -0.15 0 NA
137 hsa-miR-342-3p COX7A2L 1.41 0 -0.42 0 miRanda -0.12 0 NA
138 hsa-miR-342-3p CPEB4 1.41 0 -1.17 0 miRanda; miRNATAP -0.37 0 NA
139 hsa-miR-342-3p CRB1 1.41 0 -0.84 0 miRanda -0.27 6.0E-5 NA
140 hsa-miR-342-3p CRELD1 1.41 0 -0.24 0.00027 miRanda -0.11 1.0E-5 NA
141 hsa-miR-342-3p CRIM1 1.41 0 -0.46 1.0E-5 miRanda -0.21 0 NA
142 hsa-miR-342-3p CRLF1 1.41 0 -0.93 0.00233 miRanda -0.27 0.02604 NA
143 hsa-miR-342-3p CRTC1 1.41 0 -0.83 0 mirMAP -0.34 0 NA
144 hsa-miR-342-3p CS 1.41 0 -0.42 0 miRanda -0.14 0 NA
145 hsa-miR-342-3p CSMD1 1.41 0 -1.86 0 miRanda -0.4 0.0011 NA
146 hsa-miR-342-3p CTF1 1.41 0 -1.39 0 miRanda -0.43 0 NA
147 hsa-miR-342-3p CTH 1.41 0 -2.09 0 miRanda -0.59 0 NA
148 hsa-miR-342-3p CTNND1 1.41 0 -0.19 0.00104 miRanda -0.1 1.0E-5 NA
149 hsa-miR-342-3p CTNND2 1.41 0 -1.74 0 MirTarget; PITA; miRanda -0.55 0 NA
150 hsa-miR-342-3p CXADR 1.41 0 -1.74 0 miRNAWalker2 validate -0.39 6.0E-5 NA
NumGOOverlapSizeP ValueAdj. P Value
1 SMALL MOLECULE METABOLIC PROCESS 112 1767 2.989e-07 0.001391
NumGOOverlapSizeP ValueAdj. P Value
1 ADENYL NUCLEOTIDE BINDING 96 1514 2.31e-06 0.002146
NumGOOverlapSizeP ValueAdj. P Value
1 CYTOPLASMIC REGION 29 287 3.696e-06 0.002158
2 CELL CORTEX PART 16 119 1.79e-05 0.002634
3 SYNAPSE 54 754 1.804e-05 0.002634
4 MITOCHONDRION 98 1633 1.794e-05 0.002634
5 CELL CORTEX 24 238 2.579e-05 0.003012
6 CELL PROJECTION 103 1786 5.418e-05 0.004884
7 AXON PART 22 219 5.855e-05 0.004884

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 MAPK_signaling_pathway_hsa04010 22 295 0.003332 0.1733
2 Adherens_junction_hsa04520 8 72 0.00731 0.1901
3 mTOR_signaling_pathway_hsa04150 12 151 0.01661 0.2793
4 AMPK_signaling_pathway_hsa04152 10 121 0.02149 0.2793
5 Tight_junction_hsa04530 12 170 0.0373 0.3879
6 Rap1_signaling_pathway_hsa04015 13 206 0.06511 0.5643
7 Phosphatidylinositol_signaling_system_hsa04070 7 99 0.09634 0.7157
8 Regulation_of_actin_cytoskeleton_hsa04810 12 208 0.1218 0.7158
9 Phospholipase_D_signaling_pathway_hsa04072 9 146 0.1239 0.7158
10 FoxO_signaling_pathway_hsa04068 8 132 0.1511 0.736
11 Hippo_signaling_pathway_hsa04390 9 154 0.1557 0.736
12 Sphingolipid_signaling_pathway_hsa04071 7 118 0.1851 0.802
13 TNF_signaling_pathway_hsa04668 6 108 0.2539 0.9088
14 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 7 139 0.3094 0.9088
15 Cell_adhesion_molecules_.CAMs._hsa04514 7 145 0.3477 0.9088
16 Lysosome_hsa04142 6 123 0.3575 0.9088
17 Endocytosis_hsa04144 11 244 0.369 0.9088
18 cAMP_signaling_pathway_hsa04024 9 198 0.3804 0.9088
19 Focal_adhesion_hsa04510 9 199 0.386 0.9088
20 Autophagy_animal_hsa04140 6 128 0.3929 0.9088
21 Peroxisome_hsa04146 4 83 0.4153 0.9088
22 TGF_beta_signaling_pathway_hsa04350 4 84 0.4242 0.9088
23 ErbB_signaling_pathway_hsa04012 4 85 0.4331 0.9088
24 Ras_signaling_pathway_hsa04014 10 232 0.4331 0.9088
25 Apelin_signaling_pathway_hsa04371 6 137 0.4563 0.9088
26 Apoptosis_hsa04210 6 138 0.4633 0.9088
27 Ferroptosis_hsa04216 2 40 0.4719 0.9088
28 PI3K_Akt_signaling_pathway_hsa04151 14 352 0.5262 0.9161
29 ABC_transporters_hsa02010 2 45 0.5347 0.9161
30 Notch_signaling_pathway_hsa04330 2 48 0.5699 0.9161
31 ECM_receptor_interaction_hsa04512 3 82 0.633 0.9161
32 Gap_junction_hsa04540 3 88 0.68 0.9161
33 VEGF_signaling_pathway_hsa04370 2 59 0.6819 0.9161
34 Wnt_signaling_pathway_hsa04310 5 146 0.6875 0.9161
35 Phagosome_hsa04145 5 152 0.7209 0.9161
36 Oocyte_meiosis_hsa04114 4 124 0.7259 0.9161
37 Calcium_signaling_pathway_hsa04020 6 182 0.7282 0.9161
38 NF_kappa_B_signaling_pathway_hsa04064 3 95 0.7291 0.9161
39 Mitophagy_animal_hsa04137 2 65 0.7323 0.9161
40 p53_signaling_pathway_hsa04115 2 68 0.7549 0.9161
41 Jak_STAT_signaling_pathway_hsa04630 5 162 0.7706 0.9161
42 cGMP_PKG_signaling_pathway_hsa04022 5 163 0.7752 0.9161
43 Neuroactive_ligand_receptor_interaction_hsa04080 8 278 0.8616 0.9676
44 Cellular_senescence_hsa04218 4 160 0.8806 0.9676
45 HIF_1_signaling_pathway_hsa04066 2 100 0.9093 0.9676
46 Cytokine_cytokine_receptor_interaction_hsa04060 7 270 0.9118 0.9676
47 Cell_cycle_hsa04110 2 124 0.959 0.9974

Quest ID: 609208b81d766f081aedb4b925ab46c3