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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies OLS miRNA effect size OLS covariates effect size
1 hsa-miR-30b-3p A1BG 0.37 0.01253 -0.49 0.0102 MirTarget -0.22 0.00063 NA -0.21 type:-0.17, stage:0.1, histology:-0.37, age:0.02, gender:-0.27
NumGOOverlapSizeP ValueAdj. P Value
1 ERBB SIGNALING PATHWAY 10 79 3.947e-16 1.837e-12
2 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 15 498 1.617e-14 3.761e-11
3 EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 8 55 1.381e-13 2.142e-10
4 REGULATION OF CELL ADHESION 15 629 4.797e-13 5.58e-10
5 ERBB2 SIGNALING PATHWAY 7 39 1.079e-12 1.004e-09
6 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 15 689 1.776e-12 1.377e-09
7 REGULATION OF CELL CELL ADHESION 12 380 6.444e-12 4.284e-09
8 POSITIVE REGULATION OF RESPONSE TO STIMULUS 20 1929 9.111e-11 5.299e-08
9 INOSITOL LIPID MEDIATED SIGNALING 8 124 1.132e-10 5.851e-08
10 REGULATION OF HOMOTYPIC CELL CELL ADHESION 10 307 3.54e-10 1.647e-07
11 NEGATIVE REGULATION OF CELL ADHESION 9 223 4.591e-10 1.942e-07
12 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 18 1656 5.908e-10 2.291e-07
13 POSITIVE REGULATION OF CELL COMMUNICATION 17 1532 1.599e-09 5.707e-07
14 LEUKOCYTE MIGRATION 9 259 1.717e-09 5.707e-07
15 RESPONSE TO INSULIN 8 205 6.168e-09 1.754e-06
16 FC RECEPTOR SIGNALING PATHWAY 8 206 6.408e-09 1.754e-06
17 PHOSPHORYLATION 15 1228 5.722e-09 1.754e-06
18 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 74 7.249e-09 1.874e-06
19 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 7 138 9.85e-09 2.14e-06
20 LYMPHOCYTE COSTIMULATION 6 78 9.993e-09 2.14e-06
21 RESPONSE TO HORMONE 13 893 1.008e-08 2.14e-06
22 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 18 1977 1.012e-08 2.14e-06
23 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 9 323 1.178e-08 2.382e-06
24 POSITIVE REGULATION OF MOLECULAR FUNCTION 17 1791 1.702e-08 3.3e-06
25 PROTEIN PHOSPHORYLATION 13 944 1.951e-08 3.63e-06
26 CARDIOVASCULAR SYSTEM DEVELOPMENT 12 788 2.602e-08 4.484e-06
27 CIRCULATORY SYSTEM DEVELOPMENT 12 788 2.602e-08 4.484e-06
28 REGULATION OF CELL ACTIVATION 10 484 2.776e-08 4.613e-06
29 FC GAMMA RECEPTOR SIGNALING PATHWAY 6 95 3.298e-08 5.116e-06
30 NEGATIVE REGULATION OF ANOIKIS 4 17 3.203e-08 5.116e-06
31 REGULATION OF IMMUNE SYSTEM PROCESS 15 1403 3.434e-08 5.154e-06
32 POSITIVE REGULATION OF CELL ADHESION 9 376 4.358e-08 6.145e-06
33 LIPID PHOSPHORYLATION 6 99 4.228e-08 6.145e-06
34 RESPONSE TO NITROGEN COMPOUND 12 859 6.711e-08 9.185e-06
35 RESPONSE TO PEPTIDE 9 404 8.05e-08 1.04e-05
36 NEGATIVE REGULATION OF CELL DEATH 12 872 7.908e-08 1.04e-05
37 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 12 876 8.312e-08 1.045e-05
38 REGULATION OF HYDROLASE ACTIVITY 14 1327 1.353e-07 1.657e-05
39 REGULATION OF ANOIKIS 4 24 1.416e-07 1.689e-05
40 INTRACELLULAR SIGNAL TRANSDUCTION 15 1572 1.543e-07 1.795e-05
41 RESPONSE TO ENDOGENOUS STIMULUS 14 1450 4.02e-07 4.562e-05
42 CELLULAR RESPONSE TO INSULIN STIMULUS 6 146 4.27e-07 4.716e-05
43 GLYCEROLIPID METABOLIC PROCESS 8 356 4.359e-07 4.716e-05
44 POSITIVE REGULATION OF CELL CELL ADHESION 7 243 4.75e-07 4.993e-05
45 REGULATION OF CELL DEATH 14 1472 4.829e-07 4.993e-05
46 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 12 1036 5.08e-07 5.029e-05
47 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 12 1036 5.08e-07 5.029e-05
48 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 14 1492 5.689e-07 5.515e-05
49 PLATELET DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 4 34 6.09e-07 5.783e-05
50 REGULATION OF IMMUNE RESPONSE 11 858 6.267e-07 5.832e-05
51 POSITIVE REGULATION OF CATALYTIC ACTIVITY 14 1518 7.013e-07 6.275e-05
52 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 11 867 6.948e-07 6.275e-05
53 EPHRIN RECEPTOR SIGNALING PATHWAY 5 85 7.205e-07 6.326e-05
54 REGULATION OF CELL MATRIX ADHESION 5 90 9.584e-07 8.258e-05
55 CELLULAR RESPONSE TO PEPTIDE 7 274 1.063e-06 8.991e-05
56 CELLULAR RESPONSE TO HORMONE STIMULUS 9 552 1.11e-06 9.06e-05
57 REGULATION OF CELLULAR PROTEIN LOCALIZATION 9 552 1.11e-06 9.06e-05
58 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 12 1135 1.336e-06 0.0001072
59 REGULATION OF PHOSPHORUS METABOLIC PROCESS 14 1618 1.511e-06 0.0001191
60 RESPONSE TO OXYGEN CONTAINING COMPOUND 13 1381 1.585e-06 0.0001229
61 REGULATION OF PROTEIN LOCALIZATION 11 950 1.704e-06 0.00013
62 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 7 297 1.818e-06 0.0001364
63 REGULATION OF CELLULAR COMPONENT BIOGENESIS 10 767 1.935e-06 0.0001429
64 PHAGOCYTOSIS 6 190 1.993e-06 0.0001449
65 REGULATION OF KINASE ACTIVITY 10 776 2.148e-06 0.0001538
66 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 6 193 2.183e-06 0.0001539
67 REGULATION OF ACTIN FILAMENT BASED PROCESS 7 312 2.52e-06 0.000175
68 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE I PROMOTER 3 14 2.657e-06 0.0001818
69 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 4 49 2.723e-06 0.0001836
70 REGULATION OF PROTEIN MODIFICATION PROCESS 14 1710 2.915e-06 0.0001938
71 IMMUNE SYSTEM PROCESS 15 1984 3.05e-06 0.0001999
72 HEART DEVELOPMENT 8 466 3.268e-06 0.0002112
73 NEUROTROPHIN TRK RECEPTOR SIGNALING PATHWAY 3 15 3.316e-06 0.0002114
74 WOUND HEALING 8 470 3.481e-06 0.0002189
75 LIPID MODIFICATION 6 210 3.556e-06 0.0002199
76 REGULATION OF ANATOMICAL STRUCTURE SIZE 8 472 3.592e-06 0.0002199
77 RESPONSE TO GROWTH FACTOR 8 475 3.763e-06 0.0002274
78 POSITIVE REGULATION OF KINASE ACTIVITY 8 482 4.192e-06 0.0002408
79 REGULATION OF CELLULAR COMPONENT SIZE 7 337 4.189e-06 0.0002408
80 CELL MOTILITY 10 835 4.133e-06 0.0002408
81 LOCALIZATION OF CELL 10 835 4.133e-06 0.0002408
82 PEPTIDYL AMINO ACID MODIFICATION 10 841 4.404e-06 0.0002499
83 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 12 1275 4.493e-06 0.0002519
84 REGULATION OF CELLULAR LOCALIZATION 12 1277 4.567e-06 0.000253
85 REGULATION OF CYTOSKELETON ORGANIZATION 8 502 5.651e-06 0.0003058
86 REGULATION OF GTPASE ACTIVITY 9 673 5.628e-06 0.0003058
87 CELLULAR RESPONSE TO NITROGEN COMPOUND 8 505 5.904e-06 0.0003157
88 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 7 360 6.457e-06 0.0003414
89 PHOSPHOLIPID METABOLIC PROCESS 7 364 6.94e-06 0.0003588
90 BLOOD VESSEL MORPHOGENESIS 7 364 6.94e-06 0.0003588
91 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 14 1848 7.243e-06 0.0003704
92 LOCOMOTION 11 1114 7.9e-06 0.0003995
93 REGULATION OF PROTEIN COMPLEX ASSEMBLY 7 375 8.427e-06 0.0004216
94 PEPTIDYL SERINE MODIFICATION 5 148 1.107e-05 0.0005445
95 BONE CELL DEVELOPMENT 3 22 1.112e-05 0.0005445
96 REGULATION OF TRANSFERASE ACTIVITY 10 946 1.24e-05 6e-04
97 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE I PROMOTER 3 23 1.277e-05 6e-04
98 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 3 23 1.277e-05 6e-04
99 NEUROTROPHIN SIGNALING PATHWAY 3 23 1.277e-05 6e-04
100 RESPONSE TO WOUNDING 8 563 1.303e-05 0.0006064
101 REGULATION OF ORGANELLE ORGANIZATION 11 1178 1.34e-05 0.0006173
102 MULTICELLULAR ORGANISM GROWTH 4 76 1.586e-05 0.0007235
103 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 3 25 1.653e-05 0.0007469
104 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 5 162 1.715e-05 0.0007673
105 RESPONSE TO LIGHT STIMULUS 6 280 1.836e-05 0.0008138
106 POSITIVE REGULATION OF GENE EXPRESSION 13 1733 1.917e-05 0.0008411
107 ACTIVATION OF IMMUNE RESPONSE 7 427 1.952e-05 0.0008411
108 INSULIN RECEPTOR SIGNALING PATHWAY 4 80 1.944e-05 0.0008411
109 POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING 4 81 2.042e-05 0.0008717
110 GLUCOSE HOMEOSTASIS 5 170 2.164e-05 0.0008988
111 CARBOHYDRATE HOMEOSTASIS 5 170 2.164e-05 0.0008988
112 INTEGRIN MEDIATED SIGNALING PATHWAY 4 82 2.144e-05 0.0008988
113 REGULATION OF DEVELOPMENTAL GROWTH 6 289 2.195e-05 0.0009038
114 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 9 799 2.222e-05 0.0009068
115 TISSUE MIGRATION 4 84 2.358e-05 0.0009458
116 REGULATION OF CELL SUBSTRATE ADHESION 5 173 2.353e-05 0.0009458
117 RESPONSE TO ABIOTIC STIMULUS 10 1024 2.461e-05 0.0009788
118 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 8 616 2.49e-05 0.0009819
119 TISSUE DEVELOPMENT 12 1518 2.638e-05 0.001032
120 NEGATIVE REGULATION OF CELL MATRIX ADHESION 3 30 2.898e-05 0.001124
121 RESPONSE TO OXYGEN LEVELS 6 311 3.313e-05 0.00126
122 POSITIVE REGULATION OF CELL ACTIVATION 6 311 3.313e-05 0.00126
123 PEPTIDYL TYROSINE MODIFICATION 5 186 3.331e-05 0.00126
124 VASCULATURE DEVELOPMENT 7 469 3.557e-05 0.001335
125 PROTEIN AUTOPHOSPHORYLATION 5 192 3.877e-05 0.001443
126 REGULATION OF PROTEIN DEACETYLATION 3 34 4.248e-05 0.001569
127 ORGANOPHOSPHATE METABOLIC PROCESS 9 885 4.951e-05 0.001814
128 EMBRYO DEVELOPMENT 9 894 5.356e-05 0.001947
129 POSITIVE REGULATION OF HYDROLASE ACTIVITY 9 905 5.888e-05 0.002124
130 ENDOCYTOSIS 7 509 5.972e-05 0.002137
131 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 7 513 6.274e-05 0.002228
132 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 5 213 6.35e-05 0.002239
133 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 10 1152 6.702e-05 0.002329
134 NEUROGENESIS 11 1402 6.706e-05 0.002329
135 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 3 40 6.956e-05 0.002397
136 CIRCULATORY SYSTEM PROCESS 6 366 8.18e-05 0.002799
137 MYELOID CELL DEVELOPMENT 3 44 9.273e-05 0.003149
138 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 4 120 9.532e-05 0.003214
139 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 8 750 9.984e-05 0.003295
140 REGULATION OF PROTEIN KINASE B SIGNALING 4 121 9.844e-05 0.003295
141 REGULATION OF CELL MORPHOGENESIS 7 552 9.927e-05 0.003295
142 REGULATION OF ERK1 AND ERK2 CASCADE 5 238 0.0001072 0.003512
143 POSITIVE REGULATION OF IMMUNE RESPONSE 7 563 0.0001122 0.003652
144 RESPONSE TO UV 4 126 0.0001151 0.003721
145 REGULATION OF CELL DIFFERENTIATION 11 1492 0.0001175 0.00377
146 REGULATION OF LIPID KINASE ACTIVITY 3 48 0.0001204 0.003827
147 REGULATION OF CELLULAR COMPONENT MOVEMENT 8 771 0.0001209 0.003827
148 GLAND DEVELOPMENT 6 395 0.0001243 0.003907
149 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 7 573 0.0001252 0.00391
150 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 9 1008 0.0001345 0.004173
151 REGULATION OF ADHERENS JUNCTION ORGANIZATION 3 50 0.0001361 0.004194
152 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 6 404 0.0001405 0.004301
153 RESPONSE TO RADIATION 6 413 0.0001584 0.004817
154 NEGATIVE REGULATION OF CELL SUBSTRATE ADHESION 3 53 0.000162 0.004894
155 NEGATIVE REGULATION OF CELL CELL ADHESION 4 138 0.0001635 0.004909
156 REGULATION OF CELL SHAPE 4 139 0.0001681 0.005015
157 PLATELET ACTIVATION 4 142 0.0001825 0.005375
158 FC EPSILON RECEPTOR SIGNALING PATHWAY 4 142 0.0001825 0.005375
159 CELLULAR RESPONSE TO OXYGEN LEVELS 4 143 0.0001875 0.005487
160 ENDOTHELIAL CELL MIGRATION 3 57 0.0002012 0.005851
161 REGULATION OF INTRACELLULAR TRANSPORT 7 621 0.0002056 0.005941
162 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 6 437 0.000215 0.006138
163 POSITIVE REGULATION OF CELL GROWTH 4 148 0.0002139 0.006138
164 REGULATION OF INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY 3 59 0.0002229 0.006211
165 ORGAN MORPHOGENESIS 8 841 0.0002196 0.006211
166 VASCULOGENESIS 3 59 0.0002229 0.006211
167 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 3 59 0.0002229 0.006211
168 ACTIVATION OF PROTEIN KINASE ACTIVITY 5 279 0.0002249 0.006229
169 HOMEOSTATIC PROCESS 10 1337 0.0002297 0.006323
170 REGULATION OF GROWTH 7 633 0.0002311 0.006325
171 REGULATION OF LIPID METABOLIC PROCESS 5 282 0.0002363 0.00643
172 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 3 61 0.0002461 0.006658
173 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 4 154 0.000249 0.006658
174 AMEBOIDAL TYPE CELL MIGRATION 4 154 0.000249 0.006658
175 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 2 12 0.0002542 0.006758
176 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 3 62 0.0002583 0.006828
177 REGULATION OF ACTIN FILAMENT LENGTH 4 156 0.0002616 0.006876
178 ANGIOGENESIS 5 293 0.000282 0.007329
179 CENTRAL NERVOUS SYSTEM DEVELOPMENT 8 872 0.0002807 0.007329
180 CHEMICAL HOMEOSTASIS 8 874 0.0002851 0.00737
181 POSITIVE REGULATION OF MAPK CASCADE 6 470 0.0003179 0.008172
182 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 11 1672 0.0003205 0.008194
183 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 10 1395 0.0003237 0.008223
184 POSITIVE REGULATION OF CELL DEVELOPMENT 6 472 0.0003252 0.008223
185 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 5 303 0.000329 0.008275
186 REGULATION OF CELL JUNCTION ASSEMBLY 3 68 0.0003394 0.008445
187 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 3 68 0.0003394 0.008445
188 POSITIVE REGULATION OF NEURON DIFFERENTIATION 5 306 0.0003442 0.00852
189 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 2 14 0.0003496 0.008606
190 REGULATION OF CELL SIZE 4 172 0.0003791 0.009161
191 LIPID METABOLIC PROCESS 9 1158 0.0003795 0.009161
192 POSITIVE REGULATION OF ERK1 AND ERK2 CASCADE 4 172 0.0003791 0.009161
193 IMMUNE EFFECTOR PROCESS 6 486 0.00038 0.009161
194 CELLULAR LIPID METABOLIC PROCESS 8 913 0.0003825 0.009174
195 REGULATION OF PROTEIN POLYMERIZATION 4 173 0.0003875 0.0092
196 CELL DEVELOPMENT 10 1426 0.0003861 0.0092
197 RESPONSE TO ORGANIC CYCLIC COMPOUND 8 917 0.0003939 0.009303
198 POSITIVE REGULATION OF CYTOSKELETON ORGANIZATION 4 175 0.0004048 0.009512
199 REGULATION OF MAP KINASE ACTIVITY 5 319 0.0004164 0.009737
NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 6 70 5.161e-09 4.794e-06
2 KINASE ACTIVITY 12 842 5.393e-08 2.505e-05
3 ENZYME BINDING 16 1737 8.186e-08 2.535e-05
4 SIGNALING ADAPTOR ACTIVITY 5 74 3.596e-07 6.681e-05
5 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 12 992 3.193e-07 6.681e-05
6 INSULIN RECEPTOR SUBSTRATE BINDING 3 11 1.209e-06 0.0001872
7 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 4 43 1.6e-06 0.0002123
8 KINASE BINDING 9 606 2.395e-06 0.0002781
9 PROTEIN KINASE ACTIVITY 9 640 3.741e-06 0.000316
10 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 4 51 3.202e-06 0.000316
11 SH3 SH2 ADAPTOR ACTIVITY 4 52 3.464e-06 0.000316
12 MOLECULAR FUNCTION REGULATOR 12 1353 8.265e-06 0.0006399
13 PROTEIN DIMERIZATION ACTIVITY 11 1149 1.059e-05 0.0007569
14 PROTEIN TYROSINE KINASE ACTIVITY 5 176 2.556e-05 0.001517
15 SH2 DOMAIN BINDING 3 29 2.612e-05 0.001517
16 BINDING BRIDGING 5 173 2.353e-05 0.001517
17 INSULIN RECEPTOR BINDING 3 32 3.531e-05 0.00193
18 PROTEIN HOMODIMERIZATION ACTIVITY 8 722 7.658e-05 0.003952
19 PROTEIN PHOSPHATASE BINDING 4 120 9.532e-05 0.004428
20 ENZYME REGULATOR ACTIVITY 9 959 9.201e-05 0.004428
21 IDENTICAL PROTEIN BINDING 10 1209 0.0001004 0.00444
22 RECEPTOR BINDING 11 1476 0.0001067 0.004504
23 ADENYL NUCLEOTIDE BINDING 11 1514 0.0001339 0.005408
24 PROTEIN TYROSINE KINASE BINDING 3 54 0.0001713 0.00663
25 PROTEIN DOMAIN SPECIFIC BINDING 7 624 0.0002117 0.007867
26 PHOSPHOPROTEIN BINDING 3 60 0.0002343 0.008373
NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 4 20 6.492e-08 3.792e-05
2 EXTRINSIC COMPONENT OF MEMBRANE 6 252 1.011e-05 0.002951

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 ErbB_signaling_pathway_hsa04012 10 85 8.503e-16 4.421e-14
2 Focal_adhesion_hsa04510 9 199 1.67e-10 4.342e-09
3 HIF_1_signaling_pathway_hsa04066 6 100 4.491e-08 7.784e-07
4 VEGF_signaling_pathway_hsa04370 5 59 1.142e-07 1.485e-06
5 FoxO_signaling_pathway_hsa04068 6 132 2.354e-07 2.448e-06
6 Ras_signaling_pathway_hsa04014 7 232 3.475e-07 2.972e-06
7 PI3K_Akt_signaling_pathway_hsa04151 8 352 4.001e-07 2.972e-06
8 Jak_STAT_signaling_pathway_hsa04630 6 162 7.867e-07 5.113e-06
9 MAPK_signaling_pathway_hsa04010 7 295 1.738e-06 1.004e-05
10 Regulation_of_actin_cytoskeleton_hsa04810 6 208 3.365e-06 1.75e-05
11 Autophagy_animal_hsa04140 5 128 5.458e-06 2.58e-05
12 Phospholipase_D_signaling_pathway_hsa04072 5 146 1.037e-05 4.492e-05
13 mTOR_signaling_pathway_hsa04150 5 151 1.221e-05 4.882e-05
14 Rap1_signaling_pathway_hsa04015 5 206 5.42e-05 0.0002013
15 Apoptosis_hsa04210 4 138 0.0001635 0.0005669
16 Mitophagy_animal_hsa04137 3 65 0.0002971 0.0009654
17 Adherens_junction_hsa04520 3 72 0.0004017 0.001229
18 cAMP_signaling_pathway_hsa04024 4 198 0.0006444 0.001862
19 Phosphatidylinositol_signaling_system_hsa04070 3 99 0.001018 0.002785
20 TNF_signaling_pathway_hsa04668 3 108 0.001308 0.003402
21 Sphingolipid_signaling_pathway_hsa04071 3 118 0.001687 0.004177
22 AMPK_signaling_pathway_hsa04152 3 121 0.001813 0.004284
23 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 3 139 0.002689 0.00608
24 Cellular_senescence_hsa04218 3 160 0.003996 0.008658
25 Tight_junction_hsa04530 3 170 0.004733 0.009844
26 Gap_junction_hsa04540 2 88 0.0134 0.02679
27 Wnt_signaling_pathway_hsa04310 2 146 0.03445 0.06635
28 Calcium_signaling_pathway_hsa04020 2 182 0.05127 0.09521
29 Endocytosis_hsa04144 2 244 0.08548 0.1434

Quest ID: 62216eceb863ba1495d159c0c92da3cd