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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-221-5p ABCG4 1.89 0 -0.68 0.19321 MirTarget -0.25 0.02382 NA
2 hsa-miR-221-5p ADCY1 1.89 0 -1.67 0.00025 mirMAP -0.23 0.02054 NA
3 hsa-miR-221-5p APC2 1.89 0 -1.51 0.00013 mirMAP -0.34 4.0E-5 NA
4 hsa-miR-221-5p AR 1.89 0 -3.7 0 mirMAP -0.44 0.0004 23770851; 25846647 Overexpressing of miR-221 in LNCaP reduced the transcription of a subgroup of androgen-responsive genes without affecting the androgen receptor AR or AR-androgen integrity; We hypothesize that a major biological consequence of upregulation of miR-221 is reprogramming of AR signaling which in turn may mediate the transition to the CRPC phenotype;Unexpectedly it was found that treatment with the AR agonists resulted in the repression of miR-221 a miRNA previously established to be involved with prostate cancer development
5 hsa-miR-221-5p BSN 1.89 0 -1.42 0.00148 MirTarget; miRNATAP -0.19 0.0457 NA
6 hsa-miR-221-5p CDC42BPA 1.89 0 -0.97 0.0006 MirTarget -0.14 0.01666 NA
7 hsa-miR-221-5p CGNL1 1.89 0 -3.61 0 mirMAP -0.35 0.00416 NA
8 hsa-miR-221-5p CHAD 1.89 0 -3.17 0 MirTarget -0.27 0.03775 NA
9 hsa-miR-221-5p CHD5 1.89 0 -2.97 0.00012 mirMAP -0.42 0.01177 NA
10 hsa-miR-221-5p CNTN2 1.89 0 -3.33 0 mirMAP -0.58 4.0E-5 NA
11 hsa-miR-221-5p CRY2 1.89 0 -1.72 0 mirMAP -0.18 6.0E-5 NA
12 hsa-miR-221-5p CYS1 1.89 0 -1.55 0.00223 mirMAP -0.32 0.00275 NA
13 hsa-miR-221-5p DPYSL5 1.89 0 -0.46 0.58021 mirMAP; miRNATAP -0.5 0.00432 NA
14 hsa-miR-221-5p FBXL7 1.89 0 -1.32 0.00038 MirTarget -0.18 0.02264 NA
15 hsa-miR-221-5p FGF9 1.89 0 -1.75 0.01133 miRNATAP -0.32 0.02829 NA
16 hsa-miR-221-5p FYCO1 1.89 0 -1.52 0 mirMAP -0.19 0.00026 NA
17 hsa-miR-221-5p GAS7 1.89 0 -1.48 0.00112 mirMAP -0.24 0.01273 NA
18 hsa-miR-221-5p GFRA1 1.89 0 -4.29 0 MirTarget -0.47 0.00359 NA
19 hsa-miR-221-5p GNAO1 1.89 0 -2.54 0 mirMAP -0.39 0.00056 NA
20 hsa-miR-221-5p GPC6 1.89 0 -1.04 0.04756 MirTarget -0.37 0.00088 NA
21 hsa-miR-221-5p GRIK2 1.89 0 -2.17 0.00297 miRNATAP -0.4 0.01031 NA
22 hsa-miR-221-5p GRIK3 1.89 0 -5.07 0 MirTarget -0.86 0 NA
23 hsa-miR-221-5p HEG1 1.89 0 -0.16 0.64111 mirMAP -0.16 0.02438 NA
24 hsa-miR-221-5p HOXA4 1.89 0 -0.15 0.70635 miRNATAP -0.21 0.01252 NA
25 hsa-miR-221-5p HPCAL4 1.89 0 -3.11 0 MirTarget; miRNATAP -0.32 0.02497 NA
26 hsa-miR-221-5p IGFBP5 1.89 0 -2.21 0 mirMAP; miRNATAP -0.37 0.00016 NA
27 hsa-miR-221-5p ITPKB 1.89 0 -0.8 0.00555 mirMAP -0.25 4.0E-5 NA
28 hsa-miR-221-5p JAM3 1.89 0 -1.46 2.0E-5 mirMAP -0.23 0.00135 NA
29 hsa-miR-221-5p KCNA6 1.89 0 -2.22 0.00097 mirMAP -0.57 6.0E-5 NA
30 hsa-miR-221-5p KCNIP3 1.89 0 -1.41 0.00207 MirTarget -0.2 0.03617 NA
31 hsa-miR-221-5p KCNK3 1.89 0 -2.78 0 mirMAP -0.44 0.00024 NA
32 hsa-miR-221-5p KCTD15 1.89 0 -0.41 0.37217 MirTarget -0.23 0.01843 NA
33 hsa-miR-221-5p KIAA1614 1.89 0 -0.76 0.03918 mirMAP -0.23 0.00312 NA
34 hsa-miR-221-5p KIF1C 1.89 0 -1.17 0 miRNATAP -0.13 0.00548 NA
35 hsa-miR-221-5p LPP 1.89 0 -0.86 0.0003 mirMAP -0.13 0.01163 NA
36 hsa-miR-221-5p LTBP4 1.89 0 -1.57 0 mirMAP -0.24 0.00013 NA
37 hsa-miR-221-5p MAOA 1.89 0 -1.88 4.0E-5 MirTarget -0.23 0.01817 NA
38 hsa-miR-221-5p MAP3K3 1.89 0 -0.64 0.00017 mirMAP -0.11 0.00189 NA
39 hsa-miR-221-5p MAPK8IP1 1.89 0 -1.25 0.00096 MirTarget -0.16 0.04263 NA
40 hsa-miR-221-5p MDGA1 1.89 0 -0.91 0.1494 mirMAP -0.33 0.01291 NA
41 hsa-miR-221-5p METRN 1.89 0 -0.76 0.04121 mirMAP -0.16 0.03668 NA
42 hsa-miR-221-5p MPP2 1.89 0 -1.69 0.00151 mirMAP -0.34 0.00241 NA
43 hsa-miR-221-5p MXD4 1.89 0 -0.84 8.0E-5 mirMAP -0.12 0.00965 NA
44 hsa-miR-221-5p MXRA7 1.89 0 -0.49 0.15506 mirMAP -0.15 0.03481 NA
45 hsa-miR-221-5p NFASC 1.89 0 -1.62 0.00154 mirMAP -0.3 0.0058 NA
46 hsa-miR-221-5p NFIC 1.89 0 -1.52 0 mirMAP -0.18 0.00048 NA
47 hsa-miR-221-5p NFIX 1.89 0 -1.29 0 mirMAP -0.14 0.01001 NA
48 hsa-miR-221-5p NOX5 1.89 0 -1.3 0.08842 mirMAP -0.54 0.00077 NA
49 hsa-miR-221-5p NPTX1 1.89 0 -2.21 0.00675 mirMAP -0.53 0.00226 NA
50 hsa-miR-221-5p NTN1 1.89 0 -2.25 3.0E-5 mirMAP; miRNATAP -0.32 0.00493 NA
51 hsa-miR-221-5p PDE4D 1.89 0 -1.48 0 miRNATAP -0.15 0.01833 NA
52 hsa-miR-221-5p PLEKHO2 1.89 0 -0.47 0.03957 MirTarget -0.12 0.01152 NA
53 hsa-miR-221-5p PLIN4 1.89 0 -3.92 0 mirMAP -0.62 0 NA
54 hsa-miR-221-5p PLXDC2 1.89 0 -0.06 0.89672 MirTarget -0.22 0.01465 NA
55 hsa-miR-221-5p PPM1M 1.89 0 -0.53 0.01292 MirTarget -0.12 0.00885 NA
56 hsa-miR-221-5p PRICKLE2 1.89 0 -2.15 0 MirTarget -0.3 0.00044 NA
57 hsa-miR-221-5p PSKH1 1.89 0 -0.89 0 mirMAP -0.11 0.00344 NA
58 hsa-miR-221-5p PTCHD1 1.89 0 -3.45 0 mirMAP -0.49 0.00074 NA
59 hsa-miR-221-5p PTPRT 1.89 0 -2.49 0.00681 mirMAP -0.53 0.0061 NA
60 hsa-miR-221-5p RADIL 1.89 0 -1.73 0.00414 mirMAP -0.34 0.00843 NA
61 hsa-miR-221-5p RIC3 1.89 0 -3.58 0 MirTarget -0.38 0.01778 NA
62 hsa-miR-221-5p RIMS4 1.89 0 -4.72 0 mirMAP -0.51 0.00359 NA
63 hsa-miR-221-5p RPL15 1.89 0 -0.45 0.00619 miRNAWalker2 validate -0.1 0.00266 NA
64 hsa-miR-221-5p RUNX1T1 1.89 0 -1.54 0.00257 miRNATAP -0.42 0.0001 NA
65 hsa-miR-221-5p SDC2 1.89 0 -0.91 0.01242 MirTarget -0.24 0.00182 NA
66 hsa-miR-221-5p SIX5 1.89 0 -0.15 0.49449 mirMAP -0.14 0.00339 NA
67 hsa-miR-221-5p SLC8A1 1.89 0 -0.9 0.01431 MirTarget -0.17 0.03166 NA
68 hsa-miR-221-5p SORCS1 1.89 0 -5.18 0 MirTarget; miRNATAP -0.83 0 NA
69 hsa-miR-221-5p SORCS2 1.89 0 -0.9 0.12599 mirMAP -0.34 0.00618 NA
70 hsa-miR-221-5p SOX12 1.89 0 0.77 0.00823 miRNATAP -0.18 0.00391 NA
71 hsa-miR-221-5p SYNGR1 1.89 0 -2.05 0.00027 mirMAP -0.28 0.01788 NA
72 hsa-miR-221-5p THRB 1.89 0 -2.41 0 mirMAP -0.37 0.0009 NA
73 hsa-miR-221-5p TMEM63C 1.89 0 -0.77 0.41513 mirMAP -0.47 0.01876 NA
74 hsa-miR-221-5p TMOD1 1.89 0 -2.88 0 MirTarget -0.52 0 NA
75 hsa-miR-221-5p TRIL 1.89 0 -0.01 0.97565 MirTarget -0.25 0.00719 NA
76 hsa-miR-221-5p UBE2QL1 1.89 0 -2.74 1.0E-5 MirTarget -0.36 0.00807 NA
77 hsa-miR-221-5p ZCCHC24 1.89 0 -1.66 0 mirMAP -0.31 4.0E-5 NA
78 hsa-miR-221-5p ZHX3 1.89 0 -1.42 0 mirMAP -0.21 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 AXON PART 8 219 2.208e-06 0.00129
2 NEURON PROJECTION TERMINUS 6 129 1.125e-05 0.003286
3 AXON 9 418 3.56e-05 0.006169
4 SOMATODENDRITIC COMPARTMENT 11 650 4.225e-05 0.006169
5 NEURON PROJECTION 13 942 6.63e-05 0.007744
6 NEURON PART 15 1265 9.58e-05 0.009325

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Cell_adhesion_molecules_.CAMs._hsa04514 4 145 0.002496 0.1298
2 Calcium_signaling_pathway_hsa04020 3 182 0.0343 0.7224
3 Rap1_signaling_pathway_hsa04015 3 206 0.04668 0.7224
4 Oocyte_meiosis_hsa04114 2 124 0.08449 0.7224
5 Neuroactive_ligand_receptor_interaction_hsa04080 3 278 0.09478 0.7224
6 Apelin_signaling_pathway_hsa04371 2 137 0.09998 0.7224
7 MAPK_signaling_pathway_hsa04010 3 295 0.1083 0.7224
8 Wnt_signaling_pathway_hsa04310 2 146 0.1111 0.7224
9 cGMP_PKG_signaling_pathway_hsa04022 2 163 0.133 0.7401
10 Tight_junction_hsa04530 2 170 0.1423 0.7401
11 cAMP_signaling_pathway_hsa04024 2 198 0.1807 0.7789
12 Regulation_of_actin_cytoskeleton_hsa04810 2 208 0.1947 0.7789
13 PI3K_Akt_signaling_pathway_hsa04151 2 352 0.4001 1

Quest ID: 63086c1fe0c72eb2f3918400f4e3afcf