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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-425-5p ADARB1 0.09 0.93287 -0.03 0.95215 mirMAP -0.28 0 NA
2 hsa-miR-425-5p AFF2 0.09 0.93287 -0.3 0.56096 miRNATAP -0.47 3.0E-5 NA
3 hsa-miR-425-5p AMPH 0.09 0.93287 0.08 0.81124 MirTarget; miRNATAP -0.66 0 NA
4 hsa-miR-425-5p ANTXR1 0.09 0.93287 -0.05 0.96265 MirTarget -0.81 0 NA
5 hsa-miR-425-5p BCAT1 0.09 0.93287 0.28 0.58837 MirTarget -0.61 0 NA
6 hsa-miR-425-5p BEX4 0.09 0.93287 0.25 0.59458 miRNAWalker2 validate; MirTarget -0.4 0 NA
7 hsa-miR-425-5p C3orf70 0.09 0.93287 -0.01 0.99084 miRNATAP -0.23 0.00677 NA
8 hsa-miR-425-5p CACNA1E 0.09 0.93287 0.16 0.74358 mirMAP -0.55 2.0E-5 NA
9 hsa-miR-425-5p CBX6 0.09 0.93287 -0.23 0.66338 miRNATAP -0.48 0 NA
10 hsa-miR-425-5p CFL2 0.09 0.93287 -0 0.9933 miRNATAP -0.48 0 NA
11 hsa-miR-425-5p CHL1 0.09 0.93287 -0.21 0.62739 mirMAP -0.83 0 NA
12 hsa-miR-425-5p CLU 0.09 0.93287 -0.34 0.68818 miRNAWalker2 validate -0.64 0 NA
13 hsa-miR-425-5p CNTN2 0.09 0.93287 -0.4 0.51237 mirMAP -0.76 0 NA
14 hsa-miR-425-5p CYGB 0.09 0.93287 0.03 0.96776 MirTarget -0.26 0 NA
15 hsa-miR-425-5p CYYR1 0.09 0.93287 -0.01 0.98676 MirTarget -0.42 0 NA
16 hsa-miR-425-5p DIP2C 0.09 0.93287 -0.09 0.87596 MirTarget; miRNATAP -0.38 0 NA
17 hsa-miR-425-5p DPYSL2 0.09 0.93287 -0.21 0.81578 miRNAWalker2 validate -0.24 0.00044 NA
18 hsa-miR-425-5p DTNA 0.09 0.93287 -0.13 0.77152 mirMAP -0.71 0 NA
19 hsa-miR-425-5p EDIL3 0.09 0.93287 -0.21 0.68786 MirTarget -0.68 0 NA
20 hsa-miR-425-5p ERC1 0.09 0.93287 -0.14 0.85976 mirMAP -0.12 0.00041 NA
21 hsa-miR-425-5p FKBP1B 0.09 0.93287 0.05 0.87839 miRNATAP -0.25 0.00967 NA
22 hsa-miR-425-5p FOSL2 0.09 0.93287 -0.17 0.85472 mirMAP -0.18 3.0E-5 NA
23 hsa-miR-425-5p FOXN3 0.09 0.93287 -0.19 0.82238 miRNATAP -0.17 5.0E-5 NA
24 hsa-miR-425-5p FST 0.09 0.93287 0.24 0.47818 MirTarget -0.8 0 NA
25 hsa-miR-425-5p GNB5 0.09 0.93287 0 0.99838 miRNAWalker2 validate -0.29 0 NA
26 hsa-miR-425-5p GREB1 0.09 0.93287 0.11 0.68015 MirTarget -0.43 0 NA
27 hsa-miR-425-5p HHIP 0.09 0.93287 -0.12 0.78184 mirMAP -0.48 0.00042 NA
28 hsa-miR-425-5p HSPB8 0.09 0.93287 -0.12 0.82222 MirTarget -0.94 0 NA
29 hsa-miR-425-5p IGSF1 0.09 0.93287 0.64 0.2633 miRNAWalker2 validate -0.31 0.03299 NA
30 hsa-miR-425-5p IL18BP 0.09 0.93287 0.14 0.80292 MirTarget -0.31 0 NA
31 hsa-miR-425-5p ITGB3 0.09 0.93287 -0.21 0.62702 MirTarget -0.61 0 NA
32 hsa-miR-425-5p ITPR1 0.09 0.93287 -0.11 0.84082 MirTarget; miRNATAP -0.46 0 NA
33 hsa-miR-425-5p KCTD15 0.09 0.93287 -0.28 0.62495 mirMAP -0.39 0 NA
34 hsa-miR-425-5p KIAA0513 0.09 0.93287 -0 0.99849 mirMAP -0.15 0.02399 NA
35 hsa-miR-425-5p KIAA1024 0.09 0.93287 -0.17 0.4428 mirMAP -0.16 0.01251 NA
36 hsa-miR-425-5p KIAA1614 0.09 0.93287 0.17 0.41239 mirMAP -0.38 0 NA
37 hsa-miR-425-5p KIAA2022 0.09 0.93287 -0.29 0.5957 miRNATAP -1 0 NA
38 hsa-miR-425-5p KIF1A 0.09 0.93287 -0.45 0.40183 mirMAP -0.88 0 NA
39 hsa-miR-425-5p KLHL13 0.09 0.93287 0.4 0.39323 MirTarget; miRNATAP -0.32 0.0166 NA
40 hsa-miR-425-5p LCOR 0.09 0.93287 -0.39 0.34301 miRNAWalker2 validate -0.16 0.00346 NA
41 hsa-miR-425-5p LDOC1L 0.09 0.93287 -0.18 0.81217 MirTarget; mirMAP -0.12 0.00011 NA
42 hsa-miR-425-5p LONRF2 0.09 0.93287 -0.45 0.43663 mirMAP -1.41 0 NA
43 hsa-miR-425-5p LRRC15 0.09 0.93287 -0.12 0.84576 mirMAP -0.65 0 NA
44 hsa-miR-425-5p MAN1C1 0.09 0.93287 -0.21 0.62971 MirTarget -0.48 0 NA
45 hsa-miR-425-5p MBP 0.09 0.93287 -0.19 0.80709 mirMAP -0.11 0.00607 NA
46 hsa-miR-425-5p MEF2C 0.09 0.93287 -0.11 0.83648 MirTarget; miRNATAP -0.44 0 NA
47 hsa-miR-425-5p N4BP3 0.09 0.93287 0.01 0.97754 mirMAP -0.34 0 NA
48 hsa-miR-425-5p NAT8L 0.09 0.93287 0.15 0.75109 mirMAP -0.32 0.00593 NA
49 hsa-miR-425-5p NCAM1 0.09 0.93287 -0.57 0.16014 miRNATAP -0.53 0 NA
50 hsa-miR-425-5p NCF2 0.09 0.93287 0.27 0.61677 MirTarget -0.54 0 NA
51 hsa-miR-425-5p NECAB1 0.09 0.93287 0.1 0.74918 MirTarget -0.72 0 NA
52 hsa-miR-425-5p NOS1 0.09 0.93287 0.35 0.62379 mirMAP -1.01 0 NA
53 hsa-miR-425-5p NOVA2 0.09 0.93287 0.11 0.56842 mirMAP -0.31 0 NA
54 hsa-miR-425-5p NRIP3 0.09 0.93287 0.15 0.54099 MirTarget -0.32 1.0E-5 NA
55 hsa-miR-425-5p OSBPL8 0.09 0.93287 0.02 0.9807 miRNATAP -0.11 0.00084 NA
56 hsa-miR-425-5p PAFAH1B1 0.09 0.93287 -0.09 0.92621 MirTarget; miRNATAP -0.14 0 NA
57 hsa-miR-425-5p PCDHB5 0.09 0.93287 -0.03 0.92998 MirTarget -0.65 0 NA
58 hsa-miR-425-5p PDE4A 0.09 0.93287 -0.3 0.67024 miRNATAP -0.13 0.006 NA
59 hsa-miR-425-5p PHF21A 0.09 0.93287 -0.04 0.95023 MirTarget -0.14 0 NA
60 hsa-miR-425-5p PIP4K2A 0.09 0.93287 0.07 0.91398 miRNAWalker2 validate -0.21 0 NA
61 hsa-miR-425-5p PNMAL1 0.09 0.93287 0.09 0.80783 MirTarget -0.82 0 NA
62 hsa-miR-425-5p PPM1L 0.09 0.93287 -0.4 0.1705 MirTarget -0.15 0.00629 NA
63 hsa-miR-425-5p PSD3 0.09 0.93287 -0.09 0.89146 mirMAP -0.18 0.00139 NA
64 hsa-miR-425-5p PTCHD1 0.09 0.93287 -0.63 0.30471 mirMAP -0.89 0 NA
65 hsa-miR-425-5p PTPN7 0.09 0.93287 -0.22 0.6572 MirTarget -0.23 0.03372 NA
66 hsa-miR-425-5p PTPRT 0.09 0.93287 -0.34 0.53832 mirMAP -0.54 2.0E-5 NA
67 hsa-miR-425-5p QKI 0.09 0.93287 0.08 0.90806 miRNAWalker2 validate -0.45 0 NA
68 hsa-miR-425-5p RAB8B 0.09 0.93287 -0.02 0.96785 miRNATAP -0.25 0 NA
69 hsa-miR-425-5p RABGAP1L 0.09 0.93287 0.05 0.92427 miRNATAP -0.16 1.0E-5 NA
70 hsa-miR-425-5p RGS13 0.09 0.93287 -0.02 0.97104 MirTarget -0.37 0.00615 NA
71 hsa-miR-425-5p RNF11 0.09 0.93287 -0.06 0.94417 MirTarget; miRNATAP -0.13 0 NA
72 hsa-miR-425-5p RNF168 0.09 0.93287 -0.27 0.53521 MirTarget -0.12 0.0035 NA
73 hsa-miR-425-5p RYR2 0.09 0.93287 0.12 0.77945 MirTarget -0.62 0 NA
74 hsa-miR-425-5p SAMD4A 0.09 0.93287 0.02 0.97728 miRNATAP -0.39 0 NA
75 hsa-miR-425-5p SCN4B 0.09 0.93287 -0.18 0.56485 mirMAP -0.54 0 NA
76 hsa-miR-425-5p SERPINE1 0.09 0.93287 0.16 0.84596 MirTarget; miRNATAP -0.54 0 NA
77 hsa-miR-425-5p SLC1A2 0.09 0.93287 -0.34 0.43423 mirMAP -0.37 3.0E-5 NA
78 hsa-miR-425-5p SMAD4 0.09 0.93287 -0.23 0.76581 mirMAP -0.13 0.00134 NA
79 hsa-miR-425-5p SNAP91 0.09 0.93287 -0.55 0.41299 miRNATAP -0.78 0 NA
80 hsa-miR-425-5p SSBP2 0.09 0.93287 0.39 0.26784 mirMAP -0.48 0 NA
81 hsa-miR-425-5p SYNJ1 0.09 0.93287 0.01 0.97922 miRNATAP -0.1 0.00133 NA
82 hsa-miR-425-5p SYT2 0.09 0.93287 0.24 0.43341 mirMAP -0.19 0.02 NA
83 hsa-miR-425-5p TAOK1 0.09 0.93287 -0.33 0.54811 miRNAWalker2 validate -0.23 1.0E-5 NA
84 hsa-miR-425-5p TBCEL 0.09 0.93287 -0.11 0.80667 MirTarget -0.2 5.0E-5 NA
85 hsa-miR-425-5p TEAD1 0.09 0.93287 -0.1 0.908 mirMAP -0.12 0.00027 NA
86 hsa-miR-425-5p THEMIS 0.09 0.93287 -0.2 0.58352 MirTarget -0.36 0.00094 NA
87 hsa-miR-425-5p THRB 0.09 0.93287 -0.49 0.35743 MirTarget; miRNATAP -0.35 0.00813 NA
88 hsa-miR-425-5p TIFAB 0.09 0.93287 -0.19 0.70283 mirMAP -0.29 0.01287 NA
89 hsa-miR-425-5p TNC 0.09 0.93287 -0.04 0.96913 MirTarget -0.85 0 NA
90 hsa-miR-425-5p TNS1 0.09 0.93287 -0.09 0.92802 mirMAP -0.88 0 24571667 Here we show that IL-1β induces the upregulation of miR-425 which negatively regulates phosphatase and tensin homolog expression by targeting its 3' UTR; Consequently repression of phosphatase and tensin homolog by miR-425 promotes gastric cancer cell proliferation which is required to protect cells from cisplatin-induced apoptosis; Taken together our data support a critical role for NF-kappaB-dependent upregulation of miR-425 which represents a new pathway for the repression of phosphatase and tensin homolog activation and the promotion of cell survival upon IL-1β induction
91 hsa-miR-425-5p TTC9 0.09 0.93287 0.03 0.95375 mirMAP -0.24 0.00797 NA
92 hsa-miR-425-5p WDR7 0.09 0.93287 -0.12 0.82172 mirMAP -0.18 0 NA
93 hsa-miR-425-5p WTIP 0.09 0.93287 0.11 0.75663 mirMAP -0.43 0 NA
94 hsa-miR-425-5p ZFP82 0.09 0.93287 0.21 0.49887 MirTarget -0.4 2.0E-5 NA
95 hsa-miR-425-5p ZMAT3 0.09 0.93287 -0.18 0.57803 MirTarget -0.27 1.0E-5 NA
96 hsa-miR-425-5p ZNF423 0.09 0.93287 0.28 0.52202 MirTarget; miRNATAP -0.3 0.00148 NA
97 hsa-miR-425-5p ZNF677 0.09 0.93287 -0.22 0.58887 mirMAP -0.55 0 NA
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Apelin_signaling_pathway_hsa04371 7 137 4.665e-06 0.0002426
2 Hippo_signaling_pathway_hsa04390 4 154 0.006731 0.129
3 Hippo_signaling_pathway_multiple_species_hsa04392 2 29 0.00868 0.129
4 Calcium_signaling_pathway_hsa04020 4 182 0.01193 0.129
5 Phosphatidylinositol_signaling_system_hsa04070 3 99 0.0124 0.129
6 Phagosome_hsa04145 3 152 0.0378 0.3204
7 p53_signaling_pathway_hsa04115 2 68 0.04312 0.3204
8 MAPK_signaling_pathway_hsa04010 4 295 0.05545 0.3266
9 ECM_receptor_interaction_hsa04512 2 82 0.06021 0.3266
10 TGF_beta_signaling_pathway_hsa04350 2 84 0.06281 0.3266
11 cAMP_signaling_pathway_hsa04024 3 198 0.07178 0.3393
12 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.08051 0.3489
13 Cell_adhesion_molecules_.CAMs._hsa04514 2 145 0.1563 0.6252
14 Cellular_senescence_hsa04218 2 160 0.1821 0.6494
15 cGMP_PKG_signaling_pathway_hsa04022 2 163 0.1873 0.6494
16 PI3K_Akt_signaling_pathway_hsa04151 3 352 0.2438 0.726
17 Focal_adhesion_hsa04510 2 199 0.2513 0.726
18 Endocytosis_hsa04144 2 244 0.3319 0.863

Quest ID: 6359734cf4aa311e796bdd0930f0e15c