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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-199b-5p AADAC 0.45 0.25461 1.53 0 miRanda -0.16 4.0E-5 NA
2 hsa-miR-199b-5p AADAT 0.45 0.25461 3.7 0 miRanda -0.15 0.00013 NA
3 hsa-miR-429 ABAT 1.4 7.0E-5 2.16 0 MirTarget; PITA; miRanda; miRNATAP -0.2 0 NA
4 hsa-miR-429 ABCB1 1.4 7.0E-5 0.9 0.00459 miRanda -0.21 0 NA
5 hsa-miR-429 ABCB11 1.4 7.0E-5 2.63 0 miRanda -0.37 0 NA
6 hsa-miR-429 ABCB4 1.4 7.0E-5 1.52 0 miRanda -0.33 0 NA
7 hsa-miR-199b-5p ABCC6 0.45 0.25461 0.92 0 miRanda -0.1 1.0E-5 NA
8 hsa-miR-429 ABCC6P1 1.4 7.0E-5 0.64 0.01293 miRanda -0.1 0.00478 NA
9 hsa-miR-429 ABCC9 1.4 7.0E-5 2.33 0 miRanda; miRNATAP -0.25 0 NA
10 hsa-miR-199b-5p ABCG2 0.45 0.25461 1.71 0 miRanda -0.19 0 NA
11 hsa-miR-429 ABCG2 1.4 7.0E-5 1.71 0 miRanda -0.22 0 NA
12 hsa-miR-199b-5p ABHD6 0.45 0.25461 1.31 0 miRanda -0.12 0 NA
13 hsa-miR-199b-5p ACOT13 0.45 0.25461 0.49 3.0E-5 miRanda -0.14 0 NA
14 hsa-miR-429 ACOX1 1.4 7.0E-5 1.16 0 miRNATAP -0.11 0 NA
15 hsa-miR-429 ACOX2 1.4 7.0E-5 1.68 0 miRanda; miRNATAP -0.23 0 NA
16 hsa-miR-429 ACSL1 1.4 7.0E-5 2.33 0 miRNATAP -0.17 0 NA
17 hsa-miR-429 ACSL6 1.4 7.0E-5 -0.39 0.26458 miRNATAP -0.23 0 NA
18 hsa-miR-429 ACSM2A 1.4 7.0E-5 2.22 0 miRanda -0.3 0 NA
19 hsa-miR-199b-5p ACTN2 0.45 0.25461 -1.96 2.0E-5 miRanda -0.19 0.00143 NA
20 hsa-miR-429 ACTN2 1.4 7.0E-5 -1.96 2.0E-5 miRanda -0.17 0.00769 NA
21 hsa-miR-429 ACVR1C 1.4 7.0E-5 2.2 0 PITA; miRanda; miRNATAP -0.17 0 NA
22 hsa-miR-429 ACYP2 1.4 7.0E-5 0.82 0 miRanda -0.11 0 NA
23 hsa-miR-429 ADH1B 1.4 7.0E-5 3.21 0 miRanda -0.35 0 NA
24 hsa-miR-199b-5p ADH4 0.45 0.25461 4.41 0 miRanda -0.19 0.00683 NA
25 hsa-miR-199b-5p ADH6 0.45 0.25461 2.17 0 miRanda -0.21 0 NA
26 hsa-miR-199b-5p ADHFE1 0.45 0.25461 1.33 0 miRanda -0.18 0 NA
27 hsa-miR-429 AFF2 1.4 7.0E-5 -1.4 0.00046 miRNATAP -0.15 0.00654 NA
28 hsa-miR-429 AGL 1.4 7.0E-5 1.74 0 miRanda -0.1 0 NA
29 hsa-miR-199b-5p AGXT2 0.45 0.25461 2.89 0 miRanda -0.16 0.002 NA
30 hsa-miR-199b-5p AKAP6 0.45 0.25461 0.97 0 miRanda -0.11 0 NA
31 hsa-miR-429 AKAP6 1.4 7.0E-5 0.97 0 miRanda -0.12 0 NA
32 hsa-miR-199b-5p AKR1C2 0.45 0.25461 -0.25 0.39842 miRanda -0.16 2.0E-5 NA
33 hsa-miR-429 ALDH1A1 1.4 7.0E-5 0.46 0.03898 miRanda -0.25 0 NA
34 hsa-miR-199b-5p ALDH1L1 0.45 0.25461 1.8 0 miRanda -0.33 0 NA
35 hsa-miR-429 ALDH7A1 1.4 7.0E-5 0.75 0 miRanda -0.17 0 NA
36 hsa-miR-199b-5p ALKBH2 0.45 0.25461 -0.58 2.0E-5 miRanda -0.11 0 NA
37 hsa-miR-429 AMACR 1.4 7.0E-5 0.65 0.0082 miRanda -0.19 0 NA
38 hsa-miR-429 ANGPT2 1.4 7.0E-5 -1.15 0 miRanda -0.1 0.00014 NA
39 hsa-miR-429 ANGPTL3 1.4 7.0E-5 1.81 0 miRanda -0.13 0.00391 NA
40 hsa-miR-429 ANO5 1.4 7.0E-5 1.28 0.00055 miRanda -0.13 0.01089 NA
41 hsa-miR-429 APBA1 1.4 7.0E-5 1.16 0 miRNATAP -0.14 7.0E-5 NA
42 hsa-miR-429 APBB3 1.4 7.0E-5 -0.66 0 miRanda -0.11 0 NA
43 hsa-miR-429 APLN 1.4 7.0E-5 -3.69 0 miRNATAP -0.21 0 NA
44 hsa-miR-199b-5p APOC1 0.45 0.25461 0.97 6.0E-5 miRanda -0.16 0 NA
45 hsa-miR-429 APOC3 1.4 7.0E-5 2.04 0 miRanda -0.2 0.00018 NA
46 hsa-miR-199b-5p AQP11 0.45 0.25461 0.63 0.00064 miRNATAP -0.13 0 NA
47 hsa-miR-429 AR 1.4 7.0E-5 2.66 0 miRNATAP -0.3 0 NA
48 hsa-miR-429 ARPP21 1.4 7.0E-5 2.21 0 MirTarget; miRanda; miRNATAP -0.12 0.03131 NA
49 hsa-miR-199b-5p ASB4 0.45 0.25461 0.62 0.06683 miRanda -0.22 0 NA
50 hsa-miR-429 ASB4 1.4 7.0E-5 0.62 0.06683 miRNATAP -0.24 0 NA
51 hsa-miR-429 ASXL3 1.4 7.0E-5 2.69 0 miRanda -0.17 0.00094 NA
52 hsa-miR-199b-5p ATOX1 0.45 0.25461 -0.43 0.00496 mirMAP -0.11 0 NA
53 hsa-miR-429 ATP11C 1.4 7.0E-5 1.6 0 MirTarget; PITA; miRanda; miRNATAP -0.14 0 NA
54 hsa-miR-429 B4GALNT1 1.4 7.0E-5 -3.11 0 miRNATAP -0.15 0.00481 NA
55 hsa-miR-199b-5p BAAT 0.45 0.25461 1.22 1.0E-5 PITA; miRanda -0.19 0 NA
56 hsa-miR-429 BAGE 1.4 7.0E-5 -1.25 0.00088 MirTarget; miRanda -0.21 8.0E-5 NA
57 hsa-miR-429 BAGE2 1.4 7.0E-5 -0.52 0.0869 miRanda -0.11 0.01077 NA
58 hsa-miR-199b-5p BHMT 0.45 0.25461 3.29 0 miRanda -0.35 0 NA
59 hsa-miR-199b-5p BLCAP 0.45 0.25461 0.41 0.00021 PITA; miRanda; miRNATAP -0.1 0 NA
60 hsa-miR-429 BNIP3 1.4 7.0E-5 0.57 1.0E-5 miRanda -0.1 0 NA
61 hsa-miR-429 BSN 1.4 7.0E-5 -0.94 2.0E-5 miRNATAP -0.14 1.0E-5 NA
62 hsa-miR-199b-5p BTNL9 0.45 0.25461 -0.27 0.25012 miRanda -0.19 0 NA
63 hsa-miR-429 C10orf105 1.4 7.0E-5 0.39 0.0588 miRNATAP -0.12 4.0E-5 NA
64 hsa-miR-429 C1QTNF3 1.4 7.0E-5 -1.51 0 miRanda -0.19 1.0E-5 NA
65 hsa-miR-199b-5p C1orf105 0.45 0.25461 -0.82 0.00234 miRNATAP -0.15 1.0E-5 NA
66 hsa-miR-429 C1orf21 1.4 7.0E-5 0.75 0.00045 miRNATAP -0.12 7.0E-5 NA
67 hsa-miR-429 C3orf18 1.4 7.0E-5 -0.57 0.00014 miRNATAP -0.16 0 NA
68 hsa-miR-429 C8orf46 1.4 7.0E-5 0.19 0.47139 miRNATAP -0.2 0 NA
69 hsa-miR-429 CADM1 1.4 7.0E-5 0.03 0.88629 miRNATAP -0.14 0 NA
70 hsa-miR-429 CAP2 1.4 7.0E-5 -2.07 0 miRanda -0.19 0 NA
71 hsa-miR-429 CASQ2 1.4 7.0E-5 -1.17 2.0E-5 miRanda; miRNATAP -0.1 0.00874 NA
72 hsa-miR-199b-5p CAT 0.45 0.25461 1.65 0 miRanda -0.11 0 NA
73 hsa-miR-199b-5p CBLN1 0.45 0.25461 -1.23 0.0004 miRanda -0.15 0.00085 NA
74 hsa-miR-199b-5p CCDC152 0.45 0.25461 1.09 0 miRanda -0.15 0 NA
75 hsa-miR-429 CCL15 1.4 7.0E-5 -0.35 0.20249 miRanda -0.16 5.0E-5 NA
76 hsa-miR-429 CCL8 1.4 7.0E-5 -0.38 0.1127 miRanda -0.12 0.00021 NA
77 hsa-miR-429 CD109 1.4 7.0E-5 -1.84 0 miRanda -0.13 0.00097 NA
78 hsa-miR-199b-5p CD5L 0.45 0.25461 5.25 0 miRanda -0.17 0.0142 NA
79 hsa-miR-429 CDC14B 1.4 7.0E-5 1.19 0 PITA; miRanda; miRNATAP -0.15 0 NA
80 hsa-miR-429 CDH9 1.4 7.0E-5 -0.96 0.011 miRanda -0.12 0.02598 NA
81 hsa-miR-199b-5p CDNF 0.45 0.25461 1.35 0 miRanda -0.1 0 NA
82 hsa-miR-429 CECR2 1.4 7.0E-5 0.78 0.01282 PITA; miRanda; miRNATAP -0.31 0 NA
83 hsa-miR-429 CECR7 1.4 7.0E-5 -2.9 4.0E-5 miRanda -0.19 0.00776 NA
84 hsa-miR-429 CFH 1.4 7.0E-5 0.88 3.0E-5 miRanda -0.11 0.00033 NA
85 hsa-miR-429 CFHR1 1.4 7.0E-5 1.06 0.00467 miRanda -0.21 7.0E-5 NA
86 hsa-miR-199b-5p CFL2 0.45 0.25461 1.18 0 miRanda -0.12 0 NA
87 hsa-miR-429 CFL2 1.4 7.0E-5 1.18 0 MirTarget; PITA; miRanda; miRNATAP -0.14 0 NA
88 hsa-miR-199b-5p CHN2 0.45 0.25461 0.87 0 MirTarget; miRanda -0.16 0 NA
89 hsa-miR-429 CHN2 1.4 7.0E-5 0.87 0 MirTarget; PITA; miRanda; miRNATAP -0.14 0 NA
90 hsa-miR-199b-5p CHPT1 0.45 0.25461 0.3 0.01175 miRanda -0.11 0 NA
91 hsa-miR-429 CHPT1 1.4 7.0E-5 0.3 0.01175 miRanda -0.13 0 NA
92 hsa-miR-429 CLVS1 1.4 7.0E-5 -1.91 0 miRanda; miRNATAP -0.12 0.02703 NA
93 hsa-miR-199b-5p CNKSR2 0.45 0.25461 0.55 0.15771 miRanda -0.16 0.00063 NA
94 hsa-miR-429 CNTNAP3 1.4 7.0E-5 -0.11 0.74285 miRanda -0.17 0.00013 NA
95 hsa-miR-429 COL24A1 1.4 7.0E-5 -2.07 0 miRanda -0.2 0.00011 NA
96 hsa-miR-429 COL5A3 1.4 7.0E-5 -1.31 0 miRanda -0.26 0 NA
97 hsa-miR-429 CPLX2 1.4 7.0E-5 -5.16 0 miRNATAP -0.43 5.0E-5 NA
98 hsa-miR-429 CPPED1 1.4 7.0E-5 -0.16 0.18491 miRanda -0.13 0 NA
99 hsa-miR-199b-5p CRLS1 0.45 0.25461 0.22 0.0807 miRanda; miRNATAP -0.13 0 NA
100 hsa-miR-199b-5p CSAG1 0.45 0.25461 -2.18 8.0E-5 miRanda -0.16 0.02225 NA
101 hsa-miR-429 CSMD1 1.4 7.0E-5 -3.24 0 miRanda; miRNATAP -0.45 0 NA
102 hsa-miR-429 CUX2 1.4 7.0E-5 1.74 1.0E-5 miRNATAP -0.17 0.00158 NA
103 hsa-miR-429 CYP2U1 1.4 7.0E-5 1.02 0 miRNATAP -0.15 0 NA
104 hsa-miR-429 CYP7A1 1.4 7.0E-5 -0.44 0.4308 miRanda -0.36 0 NA
105 hsa-miR-199b-5p CYP7B1 0.45 0.25461 1.33 0 PITA; miRanda -0.13 4.0E-5 NA
106 hsa-miR-199b-5p DCAF8L1 0.45 0.25461 -1.28 0.00129 miRanda -0.11 0.03003 NA
107 hsa-miR-429 DDX53 1.4 7.0E-5 -1.37 0.00034 miRanda -0.28 0 NA
108 hsa-miR-429 DEFB132 1.4 7.0E-5 -0.75 0.09353 miRanda -0.28 1.0E-5 NA
109 hsa-miR-429 DHRS1 1.4 7.0E-5 1.4 0 miRanda; miRNATAP -0.11 7.0E-5 NA
110 hsa-miR-199b-5p DHRS12 0.45 0.25461 0.9 0 miRanda -0.11 0 NA
111 hsa-miR-429 DIO1 1.4 7.0E-5 1.57 2.0E-5 miRanda -0.17 0.00067 NA
112 hsa-miR-429 DIO2 1.4 7.0E-5 -1.75 4.0E-5 miRanda -0.15 0.01425 NA
113 hsa-miR-199b-5p DMD 0.45 0.25461 1.66 0 miRanda -0.11 1.0E-5 NA
114 hsa-miR-429 DMD 1.4 7.0E-5 1.66 0 miRanda; miRNATAP -0.1 0.00021 NA
115 hsa-miR-429 DMRTA1 1.4 7.0E-5 1.55 0 miRanda -0.17 3.0E-5 NA
116 hsa-miR-429 DPP4 1.4 7.0E-5 0.19 0.39295 miRNATAP -0.2 0 NA
117 hsa-miR-429 DPYS 1.4 7.0E-5 2.14 0 miRanda -0.17 0.0011 NA
118 hsa-miR-429 DYNC1I1 1.4 7.0E-5 -1.67 1.0E-5 MirTarget; miRanda -0.28 0 NA
119 hsa-miR-199b-5p EBP 0.45 0.25461 0.54 0.00102 miRanda -0.11 0 NA
120 hsa-miR-429 EIF1AY 1.4 7.0E-5 -0.58 0.42619 miRanda -0.21 0.03928 NA
121 hsa-miR-429 ELL2 1.4 7.0E-5 0.77 0 MirTarget; PITA; miRanda; miRNATAP -0.1 0 NA
122 hsa-miR-429 ELOVL6 1.4 7.0E-5 1.01 0 miRanda -0.17 0 NA
123 hsa-miR-429 EML6 1.4 7.0E-5 -1.72 0 miRNATAP -0.13 0.00011 NA
124 hsa-miR-429 ENPEP 1.4 7.0E-5 1.55 0 miRanda; mirMAP -0.2 0 NA
125 hsa-miR-199b-5p ENPP1 0.45 0.25461 1.11 0 miRanda -0.12 0 NA
126 hsa-miR-429 ENPP1 1.4 7.0E-5 1.11 0 miRanda -0.12 0 NA
127 hsa-miR-429 ESM1 1.4 7.0E-5 -4.21 0 MirTarget; miRanda -0.24 0 NA
128 hsa-miR-199b-5p ESPN 0.45 0.25461 0.82 0.00057 miRanda -0.1 0.00063 NA
129 hsa-miR-429 ESR1 1.4 7.0E-5 4.12 0 miRNATAP -0.11 0.0394 NA
130 hsa-miR-429 EYA4 1.4 7.0E-5 0.95 0.02031 miRNATAP -0.16 0.00449 NA
131 hsa-miR-199b-5p F5 0.45 0.25461 0.33 0.13065 miRanda -0.15 0 NA
132 hsa-miR-199b-5p F7 0.45 0.25461 1.19 1.0E-5 miRanda -0.16 0 NA
133 hsa-miR-429 FADS1 1.4 7.0E-5 -0.42 0.11929 miRanda -0.11 0.00251 NA
134 hsa-miR-429 FAM133A 1.4 7.0E-5 -1.84 0.00087 miRanda -0.48 0 NA
135 hsa-miR-429 FAM13C 1.4 7.0E-5 -0.54 0.04583 miRanda -0.12 0.00091 NA
136 hsa-miR-429 FAM169A 1.4 7.0E-5 -0.37 0.13291 miRanda -0.17 0 NA
137 hsa-miR-199b-5p FAM184A 0.45 0.25461 0.01 0.95662 miRanda -0.21 0 NA
138 hsa-miR-429 FAM83D 1.4 7.0E-5 -2.34 0 miRanda -0.12 7.0E-5 NA
139 hsa-miR-429 FGF12 1.4 7.0E-5 -1.13 0.00013 miRNATAP -0.18 2.0E-5 NA
140 hsa-miR-429 FGF2 1.4 7.0E-5 1.09 0.00032 mirMAP -0.19 0 NA
141 hsa-miR-199b-5p FGFBP2 0.45 0.25461 1.13 0 miRanda -0.1 0.00081 NA
142 hsa-miR-429 FH 1.4 7.0E-5 0.21 0.09353 miRanda -0.11 0 NA
143 hsa-miR-199b-5p FMO5 0.45 0.25461 1.18 0 miRanda -0.14 1.0E-5 NA
144 hsa-miR-429 FNDC5 1.4 7.0E-5 2.07 1.0E-5 miRNATAP -0.26 6.0E-5 NA
145 hsa-miR-429 FOXN4 1.4 7.0E-5 -0.96 0.0431 miRanda -0.14 0.03505 NA
146 hsa-miR-429 FSTL5 1.4 7.0E-5 -1.27 0.01386 miRNATAP -0.43 0 NA
147 hsa-miR-429 G6PC 1.4 7.0E-5 1.88 0 MirTarget; PITA; miRanda -0.13 0.01391 NA
148 hsa-miR-429 GADD45A 1.4 7.0E-5 1.18 0 miRNATAP -0.15 0 NA
149 hsa-miR-429 GADD45G 1.4 7.0E-5 1.81 0 miRNATAP -0.12 0.00123 NA
150 hsa-miR-199b-5p GATM 0.45 0.25461 1.68 0 miRanda -0.12 9.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 SMALL MOLECULE METABOLIC PROCESS 78 1767 1.541e-13 3.586e-10
2 ORGANIC ACID METABOLIC PROCESS 54 953 1.248e-13 3.586e-10
3 ORGANIC HYDROXY COMPOUND METABOLIC PROCESS 34 482 1.959e-11 2.53e-08
4 SINGLE ORGANISM CATABOLIC PROCESS 50 957 2.175e-11 2.53e-08
5 LIPID METABOLIC PROCESS 54 1158 2.222e-10 2.067e-07
6 CARBOXYLIC ACID CATABOLIC PROCESS 20 205 1.318e-09 8.758e-07
7 ORGANIC ACID CATABOLIC PROCESS 20 205 1.318e-09 8.758e-07
8 CELLULAR LIPID METABOLIC PROCESS 45 913 1.537e-09 8.938e-07
9 SMALL MOLECULE CATABOLIC PROCESS 25 328 2.079e-09 1.075e-06
10 REGULATION OF HORMONE LEVELS 29 478 1.903e-08 8.854e-06
11 ORGANONITROGEN COMPOUND CATABOLIC PROCESS 24 343 2.315e-08 9.111e-06
12 OXIDATION REDUCTION PROCESS 42 898 2.545e-08 9.111e-06
13 ORGANIC HYDROXY COMPOUND BIOSYNTHETIC PROCESS 17 175 2.468e-08 9.111e-06
14 RESPONSE TO ENDOGENOUS STIMULUS 57 1450 3.372e-08 1.121e-05
15 BILE ACID BIOSYNTHETIC PROCESS 7 20 4.099e-08 1.271e-05
16 SMALL MOLECULE BIOSYNTHETIC PROCESS 27 443 5.444e-08 1.542e-05
17 ORGANIC ANION TRANSPORT 25 387 5.632e-08 1.542e-05
18 ANION TRANSPORT 29 507 6.819e-08 1.763e-05
19 CELLULAR AMINO ACID CATABOLIC PROCESS 13 112 1.386e-07 3.394e-05
20 ALPHA AMINO ACID CATABOLIC PROCESS 12 95 1.647e-07 3.831e-05
21 MONOCARBOXYLIC ACID METABOLIC PROCESS 28 503 2.021e-07 4.478e-05
22 SINGLE ORGANISM BIOSYNTHETIC PROCESS 52 1340 2.203e-07 4.659e-05
23 REGULATION OF LIPID METABOLIC PROCESS 20 282 2.816e-07 5.697e-05
24 RESPONSE TO NITROGEN COMPOUND 38 859 4.991e-07 9.624e-05
25 ALCOHOL METABOLIC PROCESS 22 348 5.171e-07 9.624e-05
26 CARBOXYLIC ACID BIOSYNTHETIC PROCESS 19 270 6.308e-07 0.0001048
27 ORGANIC ACID BIOSYNTHETIC PROCESS 19 270 6.308e-07 0.0001048
28 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 42 1008 5.904e-07 0.0001048
29 LIPID HOMEOSTASIS 12 110 8.288e-07 0.0001285
30 LIPID BIOSYNTHETIC PROCESS 28 539 8.099e-07 0.0001285
31 ORGANIC ACID TRANSPORT 18 261 1.665e-06 0.0002498
32 FATTY ACID METABOLIC PROCESS 19 296 2.49e-06 0.0003621
33 GLYCEROLIPID METABOLIC PROCESS 21 356 2.833e-06 0.000385
34 RESPONSE TO OXYGEN CONTAINING COMPOUND 50 1381 2.896e-06 0.000385
35 BILE ACID METABOLIC PROCESS 7 35 2.807e-06 0.000385
36 MONOCARBOXYLIC ACID TRANSPORT 12 124 2.984e-06 0.0003856
37 NEUTRAL LIPID METABOLIC PROCESS 10 85 3.447e-06 0.0004334
38 REGULATION OF GLUCOSE METABOLIC PROCESS 11 106 3.905e-06 0.0004782
39 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 12 128 4.164e-06 0.0004968
40 REGULATION OF LIPID CATABOLIC PROCESS 8 52 4.343e-06 0.0005052
41 DRUG TRANSPORT 6 25 4.757e-06 0.0005381
42 CATABOLIC PROCESS 59 1773 4.857e-06 0.0005381
43 CHEMICAL HOMEOSTASIS 36 874 5.156e-06 0.0005579
44 ALPHA AMINO ACID METABOLIC PROCESS 16 229 5.332e-06 0.0005639
45 ORGANIC HYDROXY COMPOUND TRANSPORT 13 155 5.741e-06 0.0005937
46 ION TRANSPORT 46 1262 6.341e-06 0.0006414
47 STEROID METABOLIC PROCESS 16 237 8.244e-06 0.0008162
48 CELLULAR CATABOLIC PROCESS 47 1322 9.576e-06 0.0009093
49 REGULATION OF LIPID TRANSPORT 10 95 9.467e-06 0.0009093
50 RESPONSE TO CARBOHYDRATE 13 168 1.377e-05 0.001282
51 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 23 465 1.742e-05 0.001585
52 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 13 172 1.771e-05 0.001585
53 DRUG TRANSMEMBRANE TRANSPORT 5 19 1.88e-05 0.00165
54 REGULATION OF MEMBRANE POTENTIAL 19 343 2.038e-05 0.001756
55 REGULATION OF PEPTIDE TRANSPORT 16 256 2.151e-05 0.00182
56 POSITIVE REGULATION OF TRANSPORT 36 936 2.276e-05 0.001891
57 REGULATION OF LIPID BIOSYNTHETIC PROCESS 11 128 2.39e-05 0.001951
58 BEHAVIOR 24 516 3.103e-05 0.00249
59 REGULATION OF PEPTIDE SECRETION 14 209 3.288e-05 0.002593
60 SULFUR COMPOUND METABOLIC PROCESS 19 359 3.804e-05 0.00295
61 CELLULAR AMINO ACID METABOLIC PROCESS 18 332 4.444e-05 0.00339
62 RESPONSE TO HORMONE 34 893 4.741e-05 0.003558
63 CELLULAR AMINO ACID BIOSYNTHETIC PROCESS 9 93 5.189e-05 0.003832
64 ORGANONITROGEN COMPOUND METABOLIC PROCESS 56 1796 5.522e-05 0.004015
65 HOMEOSTATIC PROCESS 45 1337 5.678e-05 0.004064
66 REGULATION OF STEROL TRANSPORT 6 38 6.067e-05 0.004076
67 REGULATION OF SODIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 6 38 6.067e-05 0.004076
68 REGULATION OF STEROID METABOLIC PROCESS 8 74 6.131e-05 0.004076
69 REGULATION OF CHOLESTEROL TRANSPORT 6 38 6.067e-05 0.004076
70 TRANSMEMBRANE TRANSPORT 39 1098 5.945e-05 0.004076
71 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 57 1848 6.325e-05 0.004087
72 CELLULAR RESPONSE TO NITROGEN COMPOUND 23 505 6.246e-05 0.004087
73 MONOCARBOXYLIC ACID CATABOLIC PROCESS 9 96 6.667e-05 0.004249
74 FATTY ACID BETA OXIDATION USING ACYL COA OXIDASE 4 13 6.922e-05 0.004294
75 ALPHA LINOLENIC ACID METABOLIC PROCESS 4 13 6.922e-05 0.004294
76 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 31 799 7.328e-05 0.004486
77 POSITIVE REGULATION OF LIPID CATABOLIC PROCESS 5 25 7.847e-05 0.004742
78 MONOCARBOXYLIC ACID BIOSYNTHETIC PROCESS 12 172 8.088e-05 0.004825
79 ETHANOL METABOLIC PROCESS 4 14 9.551e-05 0.005555
80 REGULATION OF LIPOPROTEIN PARTICLE CLEARANCE 4 14 9.551e-05 0.005555
81 REGULATION OF HORMONE SECRETION 15 262 0.0001045 0.006005
82 NEGATIVE REGULATION OF LIPID METABOLIC PROCESS 8 80 0.0001072 0.006043
83 RESPONSE TO INSULIN 13 205 0.0001091 0.006043
84 CELLULAR LIPID CATABOLIC PROCESS 11 151 0.0001086 0.006043
85 LIPID LOCALIZATION 15 264 0.0001137 0.006226
86 NEGATIVE REGULATION OF TRANSPORT 21 458 0.0001183 0.006399
87 NEGATIVE REGULATION OF LIPASE ACTIVITY 4 15 0.0001284 0.006865
88 COFACTOR METABOLIC PROCESS 17 334 0.0001548 0.008184
89 RESPONSE TO ORGANIC CYCLIC COMPOUND 33 917 0.0001768 0.009245
90 RESPONSE TO PEPTIDE 19 404 0.0001797 0.009293
91 NEGATIVE REGULATION OF TRANSMEMBRANE TRANSPORT 8 87 0.0001935 0.009681
92 REGULATION OF FATTY ACID METABOLIC PROCESS 8 87 0.0001935 0.009681
93 REGULATION OF CARBOHYDRATE BIOSYNTHETIC PROCESS 8 87 0.0001935 0.009681
94 RESPONSE TO EXTRACELLULAR STIMULUS 20 441 0.0001978 0.009792
NumGOOverlapSizeP ValueAdj. P Value
1 COFACTOR BINDING 20 263 9.095e-08 8.45e-05
2 SULFUR COMPOUND BINDING 18 234 3.4e-07 0.0001579
3 PDZ DOMAIN BINDING 11 90 7.585e-07 0.0002349
4 OXIDOREDUCTASE ACTIVITY 33 719 1.327e-06 0.0003082
5 TRANSFERASE ACTIVITY TRANSFERRING NITROGENOUS GROUPS 6 23 2.797e-06 0.0005197
6 ORGANIC ANION TRANSMEMBRANE TRANSPORTER ACTIVITY 14 178 5.341e-06 0.000827
7 ORGANIC ACID TRANSMEMBRANE TRANSPORTER ACTIVITY 12 142 1.215e-05 0.001612
8 TRANSPORTER ACTIVITY 45 1276 1.843e-05 0.00214
9 PROTEIN HOMODIMERIZATION ACTIVITY 30 722 2.766e-05 0.002855
10 ACTIVE TRANSMEMBRANE TRANSPORTER ACTIVITY 19 356 3.394e-05 0.002867
11 ANION TRANSMEMBRANE TRANSPORTER ACTIVITY 17 293 3.1e-05 0.002867
12 TRANSMEMBRANE TRANSPORTER ACTIVITY 37 997 3.742e-05 0.002897
13 PYRIDOXAL PHOSPHATE BINDING 7 52 4.275e-05 0.003055
14 IDENTICAL PROTEIN BINDING 42 1209 5.047e-05 0.003349
15 HEPARIN BINDING 11 157 0.0001535 0.009332
16 MONOCARBOXYLIC ACID TRANSMEMBRANE TRANSPORTER ACTIVITY 6 45 0.0001607 0.009332
NumGOOverlapSizeP ValueAdj. P Value
1 MICROBODY PART 13 93 1.448e-08 8.454e-06
2 MICROBODY LUMEN 9 45 1.034e-07 3.019e-05
3 MICROBODY 14 134 1.732e-07 3.372e-05
4 ENDOPLASMIC RETICULUM 55 1631 7.302e-06 0.001066

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Peroxisome_hsa04146 12 83 3.553e-08 1.847e-06
2 ABC_transporters_hsa02010 6 45 0.0001607 0.00279
3 FoxO_signaling_pathway_hsa04068 10 132 0.0001609 0.00279
4 Ferroptosis_hsa04216 4 40 0.005998 0.07187
5 AMPK_signaling_pathway_hsa04152 7 121 0.00691 0.07187
6 p53_signaling_pathway_hsa04115 4 68 0.03598 0.3118
7 Autophagy_animal_hsa04140 5 128 0.08629 0.641
8 Apoptosis_hsa04210 5 138 0.1097 0.713
9 ECM_receptor_interaction_hsa04512 3 82 0.1899 1
10 Phosphatidylinositol_signaling_system_hsa04070 3 99 0.2719 1
11 PI3K_Akt_signaling_pathway_hsa04151 8 352 0.3172 1
12 Cellular_senescence_hsa04218 4 160 0.3364 1
13 cGMP_PKG_signaling_pathway_hsa04022 4 163 0.3489 1
14 Cell_cycle_hsa04110 3 124 0.3966 1
15 MAPK_signaling_pathway_hsa04010 6 295 0.4547 1
16 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 3 139 0.4691 1
17 mTOR_signaling_pathway_hsa04150 3 151 0.5241 1
18 Regulation_of_actin_cytoskeleton_hsa04810 4 208 0.5302 1
19 Hippo_signaling_pathway_hsa04390 3 154 0.5374 1
20 Tight_junction_hsa04530 3 170 0.6044 1
21 Oocyte_meiosis_hsa04114 2 124 0.6656 1
22 cAMP_signaling_pathway_hsa04024 3 198 0.7054 1
23 Apelin_signaling_pathway_hsa04371 2 137 0.718 1
24 Rap1_signaling_pathway_hsa04015 3 206 0.7304 1
25 Cell_adhesion_molecules_.CAMs._hsa04514 2 145 0.7467 1
26 Neuroactive_ligand_receptor_interaction_hsa04080 4 278 0.7516 1
27 Phagosome_hsa04145 2 152 0.7698 1
28 Ras_signaling_pathway_hsa04014 3 232 0.8001 1
29 Necroptosis_hsa04217 2 164 0.805 1
30 Endocytosis_hsa04144 3 244 0.8268 1
31 Cytokine_cytokine_receptor_interaction_hsa04060 3 270 0.8744 1
32 Focal_adhesion_hsa04510 2 199 0.8819 1

Quest ID: 64a442898e63c3bc745ae2461fefab77