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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-let-7b-5p ABL1 0.6 0.0014 -1.32 0 miRNAWalker2 validate -0.23 0 NA
2 hsa-let-7b-5p ACTA1 0.6 0.0014 -1.87 0 miRNATAP -0.55 0 NA
3 hsa-let-7b-5p ADAMTS5 0.6 0.0014 -2.16 0 miRNATAP -0.23 0.00653 NA
4 hsa-let-7b-5p ADAMTS8 0.6 0.0014 -4.33 0 MirTarget; miRNATAP -0.88 0 NA
5 hsa-let-7b-5p ADRB3 0.6 0.0014 -5.02 0 MirTarget; miRNATAP -1.1 0 NA
6 hsa-let-7b-5p AKAP6 0.6 0.0014 -3.34 0 MirTarget -0.65 0 NA
7 hsa-let-7b-5p AMOT 0.6 0.0014 -1.51 0.00385 MirTarget -0.37 0.00574 NA
8 hsa-let-7b-5p AMPH 0.6 0.0014 -2.2 0 miRNAWalker2 validate -0.41 0.0004 NA
9 hsa-let-7b-5p ANGPTL2 0.6 0.0014 -1.73 0 miRNATAP -0.44 0 NA
10 hsa-let-7b-5p ANTXR1 0.6 0.0014 -0.71 0.0159 miRNAWalker2 validate -0.25 0.00127 NA
11 hsa-let-7b-5p ARHGAP20 0.6 0.0014 -3.52 0 miRNATAP -0.64 0 NA
12 hsa-let-7b-5p ARHGEF15 0.6 0.0014 -1.38 0 MirTarget; miRNATAP -0.33 0 NA
13 hsa-let-7b-5p ARID3A 0.6 0.0014 1.28 0.00096 miRNAWalker2 validate -0.27 0.00719 NA
14 hsa-let-7b-5p ASPA 0.6 0.0014 -4.76 0 miRNAWalker2 validate -0.45 0.00275 NA
15 hsa-let-7b-5p ATP6V0A1 0.6 0.0014 -0.28 0.02782 miRNAWalker2 validate -0.1 0.00237 NA
16 hsa-let-7b-5p ATP8B4 0.6 0.0014 -1.9 0 MirTarget -0.44 0 NA
17 hsa-let-7b-5p BCAT1 0.6 0.0014 0.31 0.53319 miRNAWalker2 validate -0.42 0.00104 NA
18 hsa-let-7b-5p BEND4 0.6 0.0014 -1.97 7.0E-5 miRNATAP -0.52 6.0E-5 NA
19 hsa-let-7b-5p BNC2 0.6 0.0014 -2.95 0 miRNATAP -0.84 0 NA
20 hsa-let-7b-5p C14orf28 0.6 0.0014 -0.89 0 miRNATAP -0.17 1.0E-5 NA
21 hsa-let-7b-5p C20orf194 0.6 0.0014 -1.28 0 miRNATAP -0.15 0.00637 NA
22 hsa-let-7b-5p CACNB4 0.6 0.0014 -2.87 0 miRNATAP -0.7 0 NA
23 hsa-let-7b-5p CADM2 0.6 0.0014 -3.84 0 MirTarget; miRNATAP -0.56 0.00021 NA
24 hsa-let-7b-5p CALD1 0.6 0.0014 -2.47 0 miRNATAP -0.56 0 NA
25 hsa-let-7b-5p CBFA2T3 0.6 0.0014 -1.56 2.0E-5 miRNATAP -0.26 0.00728 NA
26 hsa-let-7b-5p CBX6 0.6 0.0014 -1.54 0 miRNAWalker2 validate -0.34 1.0E-5 NA
27 hsa-let-7b-5p CCDC141 0.6 0.0014 -2.94 0 MirTarget; miRNATAP -0.43 0.00012 NA
28 hsa-let-7b-5p CCL7 0.6 0.0014 0.13 0.82847 MirTarget -0.44 0.00415 NA
29 hsa-let-7b-5p CCND2 0.6 0.0014 -2.43 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.37 0.0002 NA
30 hsa-let-7b-5p CCR7 0.6 0.0014 0.43 0.49465 miRNATAP -0.68 2.0E-5 NA
31 hsa-let-7b-5p CD86 0.6 0.0014 -0.24 0.52761 MirTarget -0.26 0.00898 NA
32 hsa-let-7b-5p CDC34 0.6 0.0014 0.61 7.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.11 0.00448 NA
33 hsa-let-7b-5p CDV3 0.6 0.0014 -0.42 0.0021 miRNATAP -0.11 0.00291 NA
34 hsa-let-7b-5p CERCAM 0.6 0.0014 0.21 0.50968 MirTarget; miRNATAP -0.3 0.00025 NA
35 hsa-let-7b-5p CGNL1 0.6 0.0014 -3.39 0 MirTarget; miRNATAP -0.53 0 NA
36 hsa-let-7b-5p CHRD 0.6 0.0014 -2 0 MirTarget; miRNATAP -0.71 0 NA
37 hsa-let-7b-5p CKB 0.6 0.0014 -2.72 0 miRNAWalker2 validate -0.42 9.0E-5 NA
38 hsa-let-7b-5p COL15A1 0.6 0.0014 -0.94 0.00988 miRNATAP -0.55 0 NA
39 hsa-let-7b-5p COL1A1 0.6 0.0014 -0.11 0.82007 miRNATAP -0.44 0.0004 NA
40 hsa-let-7b-5p COL1A2 0.6 0.0014 -0.91 0.05362 MirTarget; miRNATAP -0.48 7.0E-5 NA
41 hsa-let-7b-5p COL3A1 0.6 0.0014 -0.57 0.24631 MirTarget; miRNATAP -0.52 3.0E-5 NA
42 hsa-let-7b-5p COL4A1 0.6 0.0014 0.15 0.58169 miRNATAP -0.26 0.00021 NA
43 hsa-let-7b-5p COL4A2 0.6 0.0014 -0.28 0.30836 miRNATAP -0.32 1.0E-5 NA
44 hsa-let-7b-5p COL5A2 0.6 0.0014 0.19 0.64093 MirTarget; miRNATAP -0.33 0.00188 NA
45 hsa-let-7b-5p CPEB1 0.6 0.0014 -4.68 0 MirTarget; miRNATAP -1.09 0 NA
46 hsa-let-7b-5p CPEB4 0.6 0.0014 -1.56 0 miRNATAP -0.15 0.00798 NA
47 hsa-let-7b-5p CPM 0.6 0.0014 -0.28 0.46302 MirTarget; miRNATAP -0.56 0 NA
48 hsa-let-7b-5p CREB3L2 0.6 0.0014 -0.29 0.1662 mirMAP -0.15 0.00683 NA
49 hsa-let-7b-5p CRY2 0.6 0.0014 -1.68 0 MirTarget; miRNATAP -0.19 0 NA
50 hsa-let-7b-5p DAPK1 0.6 0.0014 0.26 0.49541 MirTarget -0.37 0.00017 NA
51 hsa-let-7b-5p DBNDD2 0.6 0.0014 -0.78 0.00784 miRNAWalker2 validate -0.25 0.00075 NA
52 hsa-let-7b-5p DCN 0.6 0.0014 -3.45 0 MirTarget -0.74 0 NA
53 hsa-let-7b-5p DLC1 0.6 0.0014 -1.8 0 miRNAWalker2 validate; miRNATAP -0.38 0 NA
54 hsa-let-7b-5p DLGAP4 0.6 0.0014 -0.04 0.72873 MirTarget -0.1 0.00035 NA
55 hsa-let-7b-5p DMD 0.6 0.0014 -3.69 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.93 0 NA
56 hsa-let-7b-5p DOCK3 0.6 0.0014 0.08 0.8798 miRNATAP -0.44 0.00082 NA
57 hsa-let-7b-5p DZIP1 0.6 0.0014 -1.57 2.0E-5 miRNAWalker2 validate; miRNATAP -0.29 0.00242 NA
58 hsa-let-7b-5p DZIP1L 0.6 0.0014 -0.53 0.1031 MirTarget -0.34 6.0E-5 NA
59 hsa-let-7b-5p ENG 0.6 0.0014 -0.23 0.26775 miRNAWalker2 validate -0.22 5.0E-5 NA
60 hsa-let-7b-5p EPB41L3 0.6 0.0014 -1.63 7.0E-5 miRNAWalker2 validate -0.57 0 NA
61 hsa-let-7b-5p EPHA3 0.6 0.0014 -3.18 0 miRNATAP -0.51 0 NA
62 hsa-let-7b-5p EPHA7 0.6 0.0014 -4.2 0 miRNATAP -0.88 0 NA
63 hsa-let-7b-5p ERC1 0.6 0.0014 -1.1 0 miRNAWalker2 validate -0.13 0.00724 NA
64 hsa-let-7b-5p FAM189A1 0.6 0.0014 -1.96 0.00881 miRNATAP -0.68 0.00039 NA
65 hsa-let-7b-5p FARP1 0.6 0.0014 0.27 0.31327 miRNAWalker2 validate -0.27 6.0E-5 NA
66 hsa-let-7b-5p FBXO32 0.6 0.0014 -0.93 0.00122 miRNATAP -0.43 0 NA
67 hsa-let-7b-5p FIGN 0.6 0.0014 -0.34 0.46881 MirTarget -0.43 0.00032 NA
68 hsa-let-7b-5p FIGNL2 0.6 0.0014 -0.15 0.72349 MirTarget -0.33 0.00301 NA
69 hsa-let-7b-5p FLNA 0.6 0.0014 -2.63 0 miRNAWalker2 validate -0.4 3.0E-5 NA
70 hsa-let-7b-5p FMNL3 0.6 0.0014 0.14 0.461 mirMAP -0.17 0.00054 NA
71 hsa-let-7b-5p FOXP2 0.6 0.0014 -3.99 0 MirTarget; miRNATAP -0.53 0.00113 NA
72 hsa-let-7b-5p FSTL1 0.6 0.0014 -1.2 3.0E-5 miRNAWalker2 validate -0.35 0 NA
73 hsa-let-7b-5p FZD4 0.6 0.0014 -0.83 0.00068 MirTarget; miRNATAP -0.22 0.0004 NA
74 hsa-let-7b-5p GAB2 0.6 0.0014 -1.2 0 MirTarget -0.35 0 NA
75 hsa-let-7b-5p GAS7 0.6 0.0014 -2.67 0 miRNATAP -0.65 0 NA
76 hsa-let-7b-5p GATA6 0.6 0.0014 -3.38 0 miRNAWalker2 validate -0.73 0 NA
77 hsa-let-7b-5p GHR 0.6 0.0014 -3.38 0 miRNATAP -0.37 0.00126 NA
78 hsa-let-7b-5p GLRX 0.6 0.0014 -0.28 0.31677 MirTarget -0.23 0.0009 NA
79 hsa-let-7b-5p GNAL 0.6 0.0014 -3.91 0 miRNATAP -0.43 0.00048 NA
80 hsa-let-7b-5p GPM6B 0.6 0.0014 -2.39 0 miRNAWalker2 validate -0.4 1.0E-5 NA
81 hsa-let-7b-5p GRIN3A 0.6 0.0014 -0.24 0.40319 miRNATAP -0.37 0 NA
82 hsa-let-7b-5p GYG1 0.6 0.0014 -0.71 0 miRNAWalker2 validate -0.19 0 NA
83 hsa-let-7b-5p GYG2 0.6 0.0014 -1.04 0.03053 miRNATAP -0.52 2.0E-5 NA
84 hsa-let-7b-5p HABP4 0.6 0.0014 -1.4 0 miRNATAP -0.42 0 NA
85 hsa-let-7b-5p HAND1 0.6 0.0014 -3.69 0 miRNAWalker2 validate; MirTarget; miRNATAP -1.21 0 NA
86 hsa-let-7b-5p HAND2 0.6 0.0014 -4.39 0 miRNATAP -1.07 0 NA
87 hsa-let-7b-5p HECTD2 0.6 0.0014 -1.26 0 miRNATAP -0.14 0.01 NA
88 hsa-let-7b-5p HIC2 0.6 0.0014 1 0.00471 miRNATAP -0.26 0.0048 NA
89 hsa-let-7b-5p HIF3A 0.6 0.0014 -4.98 0 mirMAP -1.29 0 NA
90 hsa-let-7b-5p HLF 0.6 0.0014 -5.48 0 miRNATAP -0.7 0 NA
91 hsa-let-7b-5p IGDCC3 0.6 0.0014 0.64 0.40594 MirTarget; miRNATAP -0.71 0.00028 NA
92 hsa-let-7b-5p IGDCC4 0.6 0.0014 -1.99 0 MirTarget; miRNATAP -0.53 0 NA
93 hsa-let-7b-5p IL10 0.6 0.0014 -0.99 0.03081 miRNATAP -0.47 7.0E-5 NA
94 hsa-let-7b-5p INPP5A 0.6 0.0014 -1.2 0 miRNATAP -0.24 0 NA
95 hsa-let-7b-5p ITGB3 0.6 0.0014 -2.37 0 MirTarget; miRNATAP -0.61 0 NA
96 hsa-let-7b-5p KCNA6 0.6 0.0014 -2.28 0 mirMAP -0.72 0 NA
97 hsa-let-7b-5p KCNQ4 0.6 0.0014 -2.64 0 miRNATAP -0.6 0 NA
98 hsa-let-7b-5p KCTD10 0.6 0.0014 -0.83 0 mirMAP -0.16 0 NA
99 hsa-let-7b-5p KCTD12 0.6 0.0014 -1.63 0 miRNAWalker2 validate -0.29 0.00022 NA
100 hsa-let-7b-5p KIAA2022 0.6 0.0014 -3.78 0 miRNATAP -0.82 0 NA
101 hsa-let-7b-5p KLF9 0.6 0.0014 -2.79 0 MirTarget; miRNATAP -0.34 5.0E-5 NA
102 hsa-let-7b-5p KLHDC8B 0.6 0.0014 -0.63 0.00843 MirTarget; miRNATAP -0.17 0.00555 NA
103 hsa-let-7b-5p KLHL6 0.6 0.0014 -0.44 0.25234 miRNATAP -0.37 0.00018 NA
104 hsa-let-7b-5p LBH 0.6 0.0014 0.02 0.92786 miRNATAP -0.21 0.0017 NA
105 hsa-let-7b-5p LOXL3 0.6 0.0014 -0.97 0.00081 miRNATAP -0.36 0 NA
106 hsa-let-7b-5p LPL 0.6 0.0014 -0.98 0.02055 miRNAWalker2 validate -0.61 0 NA
107 hsa-let-7b-5p LRRC17 0.6 0.0014 -1.67 0.0002 MirTarget; miRNATAP -0.44 0.00015 NA
108 hsa-let-7b-5p LSM11 0.6 0.0014 -0.97 0 miRNATAP -0.18 5.0E-5 NA
109 hsa-let-7b-5p MAP3K3 0.6 0.0014 -0.87 0 miRNATAP -0.2 0 NA
110 hsa-let-7b-5p MASP1 0.6 0.0014 -4.43 0 MirTarget -0.62 0 NA
111 hsa-let-7b-5p MED8 0.6 0.0014 0.69 0 miRNATAP -0.08 0.00881 NA
112 hsa-let-7b-5p MEF2C 0.6 0.0014 -2.13 0 miRNAWalker2 validate; miRNATAP -0.41 0 NA
113 hsa-let-7b-5p MGAT3 0.6 0.0014 -0.44 0.37044 mirMAP -0.43 0.00065 NA
114 hsa-let-7b-5p MGAT4A 0.6 0.0014 -0.02 0.93472 MirTarget; miRNATAP -0.35 0 NA
115 hsa-let-7b-5p MGLL 0.6 0.0014 -2.49 0 miRNATAP -0.44 0 NA
116 hsa-let-7b-5p MRAS 0.6 0.0014 -1.3 1.0E-5 mirMAP -0.42 0 NA
117 hsa-let-7b-5p MTAP 0.6 0.0014 -0.41 0.41816 mirMAP -0.42 0.00132 NA
118 hsa-let-7b-5p MYO1F 0.6 0.0014 -0.56 0.10146 miRNATAP -0.32 0.00029 NA
119 hsa-let-7b-5p MYRIP 0.6 0.0014 -3.81 0 miRNATAP -0.42 0.00277 NA
120 hsa-let-7b-5p NGF 0.6 0.0014 -2.41 0 MirTarget -0.45 0.00046 NA
121 hsa-let-7b-5p NOVA1 0.6 0.0014 -4.22 0 miRNATAP -0.79 0 NA
122 hsa-let-7b-5p NRK 0.6 0.0014 -1.59 0.0051 miRNATAP -0.45 0.00225 NA
123 hsa-let-7b-5p NSMCE4A 0.6 0.0014 -0.23 0.05744 miRNAWalker2 validate -0.11 0.00016 NA
124 hsa-let-7b-5p NTRK3 0.6 0.0014 -5.17 0 mirMAP -0.78 0 NA
125 hsa-let-7b-5p OSBPL10 0.6 0.0014 -1.83 0 miRNAWalker2 validate -0.38 0 NA
126 hsa-let-7b-5p PAG1 0.6 0.0014 -0.08 0.76474 MirTarget -0.19 0.00554 NA
127 hsa-let-7b-5p PAPPA 0.6 0.0014 -1.76 0.00013 MirTarget; miRNATAP -0.39 0.00106 NA
128 hsa-let-7b-5p PARM1 0.6 0.0014 -2.49 0 MirTarget -0.46 1.0E-5 NA
129 hsa-let-7b-5p PBX3 0.6 0.0014 -0.9 1.0E-5 miRNATAP -0.27 0 NA
130 hsa-let-7b-5p PCDH19 0.6 0.0014 -2.42 0 miRNATAP -0.36 0.00391 NA
131 hsa-let-7b-5p PCYT1B 0.6 0.0014 -1.54 0.00359 miRNAWalker2 validate; miRNATAP -0.38 0.00486 NA
132 hsa-let-7b-5p PDGFRA 0.6 0.0014 -2.38 0 miRNAWalker2 validate -0.52 0 NA
133 hsa-let-7b-5p PEG10 0.6 0.0014 -1.94 0.00571 miRNATAP -0.57 0.00179 NA
134 hsa-let-7b-5p PGM2L1 0.6 0.0014 -1.01 0.0001 miRNATAP -0.22 0.0009 NA
135 hsa-let-7b-5p PLA2G15 0.6 0.0014 1.09 0 MirTarget; miRNATAP -0.12 0.00689 NA
136 hsa-let-7b-5p PLCB4 0.6 0.0014 -3.77 0 miRNATAP -0.46 0.00059 NA
137 hsa-let-7b-5p PLCXD3 0.6 0.0014 -2.5 0.00093 miRNATAP -0.86 1.0E-5 NA
138 hsa-let-7b-5p PLEKHO1 0.6 0.0014 -1.45 0 miRNATAP -0.4 0 NA
139 hsa-let-7b-5p PLXDC1 0.6 0.0014 0 0.99489 mirMAP -0.21 0.00353 NA
140 hsa-let-7b-5p PLXNA4 0.6 0.0014 -2.25 5.0E-5 miRNATAP -0.82 0 NA
141 hsa-let-7b-5p PLXND1 0.6 0.0014 -0.25 0.28121 MirTarget; miRNATAP -0.26 1.0E-5 NA
142 hsa-let-7b-5p POU2F2 0.6 0.0014 -1.68 0 miRNATAP -0.53 0 NA
143 hsa-let-7b-5p PPP1R12B 0.6 0.0014 -3.46 0 miRNATAP -0.6 0 NA
144 hsa-let-7b-5p PPP1R12C 0.6 0.0014 -0.78 0 miRNAWalker2 validate -0.2 0 NA
145 hsa-let-7b-5p PPP1R16B 0.6 0.0014 -1.51 0 miRNAWalker2 validate; miRNATAP -0.4 0 NA
146 hsa-let-7b-5p PRKD1 0.6 0.0014 -1.53 4.0E-5 miRNAWalker2 validate -0.27 0.00467 NA
147 hsa-let-7b-5p PRRX1 0.6 0.0014 -1.18 0.02808 MirTarget; miRNATAP -0.71 0 NA
148 hsa-let-7b-5p PRTG 0.6 0.0014 -0.08 0.8684 miRNAWalker2 validate; MirTarget; miRNATAP -0.36 0.00295 NA
149 hsa-let-7b-5p PTGS1 0.6 0.0014 -4.36 0 miRNAWalker2 validate -0.7 0 NA
150 hsa-let-7b-5p PTPRD 0.6 0.0014 -3.63 0 miRNATAP -0.68 2.0E-5 NA
NumGOOverlapSizeP ValueAdj. P Value
1 VASCULATURE DEVELOPMENT 28 469 5.093e-14 2.37e-10
2 BLOOD VESSEL MORPHOGENESIS 22 364 2.454e-11 2.855e-08
3 CARDIOVASCULAR SYSTEM DEVELOPMENT 32 788 2.326e-11 2.855e-08
4 CIRCULATORY SYSTEM DEVELOPMENT 32 788 2.326e-11 2.855e-08
5 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 36 1021 6.151e-11 5.724e-08
6 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 33 957 7.627e-10 5.914e-07
7 ANGIOGENESIS 17 293 9.228e-09 6.134e-06
8 MUSCLE STRUCTURE DEVELOPMENT 20 432 2.01e-08 1.169e-05
9 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 42 1672 3.692e-08 1.909e-05
10 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 35 1275 7.534e-08 3.506e-05
11 TISSUE DEVELOPMENT 38 1518 2.057e-07 8.702e-05
12 LOCOMOTION 31 1114 3.472e-07 0.0001243
13 REGULATION OF CELLULAR COMPONENT MOVEMENT 25 771 3.405e-07 0.0001243
14 MULTICELLULAR ORGANISM METABOLIC PROCESS 9 93 4.598e-07 0.0001528
15 TISSUE MORPHOGENESIS 20 533 5.954e-07 0.0001847
16 MUSCLE TISSUE DEVELOPMENT 14 275 9.501e-07 0.0002629
17 MUSCLE ORGAN DEVELOPMENT 14 277 1.036e-06 0.0002629
18 TUBE DEVELOPMENT 20 552 1.026e-06 0.0002629
19 CELLULAR RESPONSE TO AMINO ACID STIMULUS 7 53 1.073e-06 0.0002629
20 CELL MOTILITY 25 835 1.461e-06 0.0003091
21 LOCALIZATION OF CELL 25 835 1.461e-06 0.0003091
22 RESPONSE TO OXYGEN CONTAINING COMPOUND 34 1381 1.459e-06 0.0003091
23 RESPONSE TO GROWTH FACTOR 18 475 1.948e-06 0.0003941
24 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 24 799 2.28e-06 0.0004421
25 CELL DEVELOPMENT 34 1426 2.963e-06 0.0005515
26 EXTRACELLULAR STRUCTURE ORGANIZATION 14 304 3.085e-06 0.0005521
27 CARDIAC CHAMBER FORMATION 4 11 3.279e-06 0.0005652
28 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 12 229 4.301e-06 0.0006591
29 POSITIVE REGULATION OF RESPONSE TO STIMULUS 41 1929 4.391e-06 0.0006591
30 MESENCHYME DEVELOPMENT 11 190 4.206e-06 0.0006591
31 REGULATION OF CELL MORPHOGENESIS 19 552 4.078e-06 0.0006591
32 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 37 1656 4.59e-06 0.0006673
33 CARTILAGE MORPHOGENESIS 4 12 4.88e-06 0.0006827
34 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 33 1395 5.008e-06 0.0006827
35 REGULATION OF VASCULATURE DEVELOPMENT 12 233 5.135e-06 0.0006827
36 TUBE MORPHOGENESIS 14 323 6.198e-06 0.0007794
37 MUSCLE CELL DIFFERENTIATION 12 237 6.11e-06 0.0007794
38 REGULATION OF DEVELOPMENTAL GROWTH 13 289 9.01e-06 0.001103
39 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 39 1848 9.337e-06 0.001114
40 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 14 337 1.003e-05 0.001167
41 POSITIVE REGULATION OF MOLECULAR FUNCTION 38 1791 1.102e-05 0.001233
42 EMBRYONIC MORPHOGENESIS 18 539 1.113e-05 0.001233
43 CELLULAR RESPONSE TO ACID CHEMICAL 10 175 1.298e-05 0.001405
44 POSITIVE REGULATION OF CELL COMMUNICATION 34 1532 1.374e-05 0.001453
45 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 28 1142 1.494e-05 0.001545
46 MULTICELLULAR ORGANISMAL MACROMOLECULE METABOLIC PROCESS 7 79 1.614e-05 0.001607
47 MORPHOGENESIS OF AN EPITHELIUM 15 400 1.623e-05 0.001607
48 REGULATION OF CELL PROJECTION ORGANIZATION 18 558 1.77e-05 0.001681
49 RETINA VASCULATURE DEVELOPMENT IN CAMERA TYPE EYE 4 16 1.738e-05 0.001681
50 REGULATION OF NEURON PROJECTION DEVELOPMENT 15 408 2.045e-05 0.001903
51 CELL ACTIVATION 18 568 2.24e-05 0.002044
52 RESPONSE TO ACID CHEMICAL 13 319 2.558e-05 0.002289
53 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 20 689 2.73e-05 0.002396
54 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 8 121 3.431e-05 0.002956
55 COLLAGEN FIBRIL ORGANIZATION 5 38 4.013e-05 0.003395
56 CELLULAR COMPONENT MORPHOGENESIS 23 900 4.92e-05 0.004088
57 ORGAN MORPHOGENESIS 22 841 5.14e-05 0.004196
58 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 25 1036 5.769e-05 0.004474
59 MAINTENANCE OF LOCATION IN CELL 7 96 5.735e-05 0.004474
60 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 25 1036 5.769e-05 0.004474
61 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 7 98 6.543e-05 0.004991
62 POSITIVE REGULATION OF CATALYTIC ACTIVITY 32 1518 6.879e-05 0.005001
63 HEART MORPHOGENESIS 10 212 6.685e-05 0.005001
64 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 24 983 6.843e-05 0.005001
65 SKELETAL SYSTEM DEVELOPMENT 15 455 7.093e-05 0.005077
66 STRIATED MUSCLE CELL DIFFERENTIATION 9 173 7.343e-05 0.005092
67 REGULATION OF CELL SUBSTRATE ADHESION 9 173 7.343e-05 0.005092
68 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 21 801 7.441e-05 0.005092
69 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 26 1135 9.543e-05 0.006436
70 REGULATION OF PHOSPHORUS METABOLIC PROCESS 33 1618 9.849e-05 0.006547
71 IMMUNE SYSTEM DEVELOPMENT 17 582 0.0001035 0.006689
72 EMBRYONIC CRANIAL SKELETON MORPHOGENESIS 5 46 0.0001026 0.006689
73 PLATELET ACTIVATION 8 142 0.0001066 0.006795
74 RESPONSE TO KETONE 9 182 0.0001083 0.006809
75 ARTERY DEVELOPMENT 6 75 0.0001173 0.006943
76 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 8 144 0.0001175 0.006943
77 REGULATION OF CELL DIFFERENTIATION 31 1492 0.0001179 0.006943
78 RESPONSE TO LIPID 22 888 0.0001134 0.006943
79 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 31 1492 0.0001179 0.006943
80 REGULATION OF PROTEIN MODIFICATION PROCESS 34 1710 0.0001246 0.00716
81 REGULATION OF CELL PROLIFERATION 31 1496 0.0001237 0.00716
82 REGULATION OF CELL DEVELOPMENT 21 836 0.0001351 0.007668
83 POSITIVE REGULATION OF HEART GROWTH 4 27 0.0001535 0.0085
84 RESPONSE TO AMINO ACID 7 112 0.000152 0.0085
85 ARTERY MORPHOGENESIS 5 51 0.0001687 0.00918
86 REGULATION OF ENDOTHELIAL CELL MIGRATION 7 114 0.0001697 0.00918
87 REGULATION OF EPITHELIAL CELL PROLIFERATION 11 285 0.0001736 0.009287
NumGOOverlapSizeP ValueAdj. P Value
1 GROWTH FACTOR BINDING 12 123 4.9e-09 4.552e-06
2 PLATELET DERIVED GROWTH FACTOR BINDING 5 11 4.621e-08 2.146e-05
3 CYTOKINE BINDING 9 92 4.189e-07 0.0001297
4 EXTRACELLULAR MATRIX STRUCTURAL CONSTITUENT 8 76 1.063e-06 0.0002469
5 GLYCOSAMINOGLYCAN BINDING 11 205 8.686e-06 0.001614
6 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 7 81 1.903e-05 0.002525
7 TRANSFORMING GROWTH FACTOR BETA BINDING 4 16 1.738e-05 0.002525
8 HEPARIN BINDING 9 157 3.449e-05 0.004006
9 SMAD BINDING 6 72 9.339e-05 0.009639
NumGOOverlapSizeP ValueAdj. P Value
1 COMPLEX OF COLLAGEN TRIMERS 7 23 2.212e-09 1.292e-06
2 BANDED COLLAGEN FIBRIL 4 12 4.88e-06 0.0008059
3 EXTRACELLULAR MATRIX COMPONENT 9 125 5.52e-06 0.0008059
4 COLLAGEN TRIMER 8 88 3.265e-06 0.0008059
5 EXTRACELLULAR MATRIX 15 426 3.366e-05 0.002808
6 FILOPODIUM MEMBRANE 4 18 2.875e-05 0.002808
7 SYNAPSE 21 754 3.127e-05 0.002808
8 ENDOPLASMIC RETICULUM LUMEN 10 201 4.27e-05 0.003117
9 ACTIN CYTOSKELETON 15 444 5.388e-05 0.003368
10 CELL PROJECTION 36 1786 5.767e-05 0.003368
11 LEADING EDGE MEMBRANE 8 134 7.098e-05 0.003768
12 PROTEINACEOUS EXTRACELLULAR MATRIX 13 356 7.87e-05 0.00383
13 POSTSYNAPSE 13 378 0.000143 0.006424

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04510_Focal_adhesion 12 200 1.049e-06 0.000148
2 hsa04974_Protein_digestion_and_absorption 8 81 1.736e-06 0.000148
3 hsa04512_ECM.receptor_interaction 8 85 2.509e-06 0.000148
4 hsa04010_MAPK_signaling_pathway 8 268 0.006383 0.2824
5 hsa04020_Calcium_signaling_pathway 6 177 0.009734 0.2831
6 hsa04722_Neurotrophin_signaling_pathway 5 127 0.009806 0.2831
7 hsa04350_TGF.beta_signaling_pathway 4 85 0.01119 0.2831
8 hsa04360_Axon_guidance 4 130 0.04429 0.871
9 hsa04144_Endocytosis 5 203 0.05734 1
10 hsa04916_Melanogenesis 3 101 0.08452 1
11 hsa00510_N.Glycan_biosynthesis 2 49 0.08917 1
12 hsa04672_Intestinal_immune_network_for_IgA_production 2 49 0.08917 1
13 hsa00561_Glycerolipid_metabolism 2 50 0.09228 1
14 hsa00562_Inositol_phosphate_metabolism 2 57 0.1149 1
15 hsa04270_Vascular_smooth_muscle_contraction 3 116 0.1155 1
16 hsa04380_Osteoclast_differentiation 3 128 0.1428 1
17 hsa04115_p53_signaling_pathway 2 69 0.1564 1
18 hsa04070_Phosphatidylinositol_signaling_system 2 78 0.1891 1
19 hsa00564_Glycerophospholipid_metabolism 2 80 0.1965 1
20 hsa04310_Wnt_signaling_pathway 3 151 0.2002 1
21 hsa04630_Jak.STAT_signaling_pathway 3 155 0.2108 1
22 hsa04145_Phagosome 3 156 0.2134 1
23 hsa04970_Salivary_secretion 2 89 0.2301 1
24 hsa04540_Gap_junction 2 90 0.2339 1
25 hsa04666_Fc_gamma_R.mediated_phagocytosis 2 95 0.2527 1
26 hsa04912_GnRH_signaling_pathway 2 101 0.2754 1
27 hsa04062_Chemokine_signaling_pathway 3 189 0.3036 1
28 hsa04142_Lysosome 2 121 0.3504 1
29 hsa04810_Regulation_of_actin_cytoskeleton 3 214 0.3732 1
30 hsa04110_Cell_cycle 2 128 0.376 1
31 hsa04530_Tight_junction 2 133 0.3941 1
32 hsa04514_Cell_adhesion_molecules_.CAMs. 2 136 0.4049 1

Quest ID: 6545a0dd6cf6717b19012de1105ec363