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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-199a-5p HNRNPA1 -0.04 0.97688 -0.16 0.9078 miRanda -0.11 0.00463 NA
2 hsa-miR-218-5p HNRNPA1 0.04 0.95125 -0.16 0.9078 miRNATAP -0.14 0 NA
3 hsa-miR-30a-5p HNRNPA1 0.26 0.88349 -0.16 0.9078 miRNAWalker2 validate -0.24 0 NA
4 hsa-miR-497-5p HNRNPA1 0.15 0.80524 -0.16 0.9078 miRNATAP -0.17 5.0E-5 NA
NumGOOverlapSizeP ValueAdj. P Value
1 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 35 1805 3.12e-15 1.452e-11
2 POSITIVE REGULATION OF GENE EXPRESSION 33 1733 4.53e-14 1.054e-10
3 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 33 1848 2.787e-13 4.322e-10
4 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 25 1004 4.016e-13 4.672e-10
5 RESPONSE TO ENDOGENOUS STIMULUS 29 1450 8.022e-13 7.466e-10
6 CELLULAR RESPONSE TO HORMONE STIMULUS 19 552 1.721e-12 1.335e-09
7 RESPONSE TO HORMONE 23 893 2.171e-12 1.443e-09
8 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 24 1008 3.43e-12 1.995e-09
9 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 31 1784 4.012e-12 2.074e-09
10 LEUKOCYTE ACTIVATION 16 414 2.193e-11 1.021e-08
11 CELL ACTIVATION 18 568 2.811e-11 1.189e-08
12 PROTEIN PHOSPHORYLATION 22 944 5.032e-11 1.951e-08
13 MYD88 DEPENDENT TOLL LIKE RECEPTOR SIGNALING PATHWAY 7 32 6.537e-11 2.34e-08
14 PHOSPHORYLATION 24 1228 2.069e-10 6.875e-08
15 PEPTIDYL AMINO ACID MODIFICATION 20 841 3.167e-10 9.823e-08
16 REGULATION OF KINASE ACTIVITY 19 776 5.856e-10 1.703e-07
17 RESPONSE TO LIPID 20 888 8.16e-10 2.233e-07
18 TOLL LIKE RECEPTOR SIGNALING PATHWAY 8 85 3.082e-09 7.967e-07
19 POSITIVE REGULATION OF RESPONSE TO STIMULUS 28 1929 3.893e-09 8.735e-07
20 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 26 1672 4.067e-09 8.735e-07
21 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 11 228 3.836e-09 8.735e-07
22 CELL DEVELOPMENT 24 1426 4.13e-09 8.735e-07
23 LEUKOCYTE DIFFERENTIATION 12 292 4.374e-09 8.849e-07
24 CARDIOVASCULAR SYSTEM DEVELOPMENT 18 788 5.309e-09 9.501e-07
25 POSITIVE REGULATION OF DEFENSE RESPONSE 13 364 5.102e-09 9.501e-07
26 CIRCULATORY SYSTEM DEVELOPMENT 18 788 5.309e-09 9.501e-07
27 CELLULAR COMPONENT MORPHOGENESIS 19 900 6.712e-09 1.157e-06
28 REGULATION OF RESPONSE TO STRESS 24 1468 7.295e-09 1.212e-06
29 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 11 246 8.466e-09 1.358e-06
30 RESPONSE TO ORGANIC CYCLIC COMPOUND 19 917 9.088e-09 1.364e-06
31 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 20 1021 8.857e-09 1.364e-06
32 REGULATION OF PHOSPHORUS METABOLIC PROCESS 25 1618 1.011e-08 1.471e-06
33 REGULATION OF MUSCLE ORGAN DEVELOPMENT 8 103 1.43e-08 2.017e-06
34 REGULATION OF TRANSFERASE ACTIVITY 19 946 1.501e-08 2.054e-06
35 ACTIVATION OF INNATE IMMUNE RESPONSE 10 204 1.764e-08 2.346e-06
36 PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 8 109 2.238e-08 2.893e-06
37 RESPONSE TO EXTERNAL STIMULUS 26 1821 2.386e-08 3.001e-06
38 LYMPHOCYTE ACTIVATION 12 342 2.537e-08 3.107e-06
39 REGULATION OF PROTEIN MODIFICATION PROCESS 25 1710 3.044e-08 3.631e-06
40 IMMUNE SYSTEM PROCESS 27 1984 3.211e-08 3.735e-06
41 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 17 799 4.255e-08 4.829e-06
42 REGULATION OF CELL DIFFERENTIATION 23 1492 4.855e-08 5.378e-06
43 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 20 1142 5.702e-08 6.17e-06
44 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 22 1395 6.873e-08 7.269e-06
45 POSITIVE REGULATION OF MOLECULAR FUNCTION 25 1791 7.547e-08 7.69e-06
46 REGULATION OF IMMUNE SYSTEM PROCESS 22 1403 7.602e-08 7.69e-06
47 POSITIVE REGULATION OF HEART GROWTH 5 27 9.793e-08 9.695e-06
48 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 13 470 1.033e-07 1.001e-05
49 NEGATIVE REGULATION OF CELL COMMUNICATION 20 1192 1.147e-07 1.089e-05
50 POSITIVE REGULATION OF IMMUNE RESPONSE 14 563 1.178e-07 1.096e-05
51 REGULATION OF DEFENSE RESPONSE 16 759 1.279e-07 1.108e-05
52 INTRACELLULAR SIGNAL TRANSDUCTION 23 1572 1.258e-07 1.108e-05
53 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 26 1977 1.255e-07 1.108e-05
54 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 11 321 1.286e-07 1.108e-05
55 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 17 876 1.593e-07 1.348e-05
56 REGULATION OF CELL DEATH 22 1472 1.76e-07 1.462e-05
57 RESPONSE TO STEROID HORMONE 13 497 1.963e-07 1.603e-05
58 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 21 1360 2.09e-07 1.677e-05
59 NEGATIVE REGULATION OF GENE EXPRESSION 22 1493 2.249e-07 1.774e-05
60 FOREBRAIN CELL MIGRATION 6 62 2.685e-07 2.058e-05
61 RESPONSE TO OXYGEN CONTAINING COMPOUND 21 1381 2.698e-07 2.058e-05
62 REGULATION OF MUSCLE TISSUE DEVELOPMENT 7 103 3.01e-07 2.092e-05
63 REGULATION OF MUSCLE CELL DIFFERENTIATION 8 152 2.974e-07 2.092e-05
64 ACTIVATION OF IMMUNE RESPONSE 12 427 2.823e-07 2.092e-05
65 BEHAVIOR 13 516 3.013e-07 2.092e-05
66 TISSUE DEVELOPMENT 22 1518 2.995e-07 2.092e-05
67 LYMPHOCYTE DIFFERENTIATION 9 209 2.869e-07 2.092e-05
68 REGULATION OF PHOSPHOLIPASE ACTIVITY 6 64 3.252e-07 2.193e-05
69 POSITIVE REGULATION OF PROTEIN IMPORT 7 104 3.216e-07 2.193e-05
70 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 8 156 3.627e-07 2.411e-05
71 REGULATION OF INNATE IMMUNE RESPONSE 11 357 3.721e-07 2.438e-05
72 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 11 365 4.634e-07 2.995e-05
73 CELLULAR RESPONSE TO LIPID 12 457 5.808e-07 3.689e-05
74 POSITIVE REGULATION OF ORGAN GROWTH 5 38 5.867e-07 3.689e-05
75 NEGATIVE REGULATION OF MOLECULAR FUNCTION 18 1079 6.063e-07 3.762e-05
76 UROGENITAL SYSTEM DEVELOPMENT 10 299 6.236e-07 3.818e-05
77 REGULATION OF PROTEIN BINDING 8 168 6.379e-07 3.855e-05
78 RESPONSE TO NITROGEN COMPOUND 16 859 6.722e-07 3.91e-05
79 REGULATION OF PHOSPHOLIPASE C ACTIVITY 5 39 6.707e-07 3.91e-05
80 REGULATION OF IMMUNE RESPONSE 16 858 6.62e-07 3.91e-05
81 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 12 465 6.975e-07 4.007e-05
82 REGULATION OF ORGAN GROWTH 6 73 7.16e-07 4.063e-05
83 SINGLE ORGANISM BEHAVIOR 11 384 7.639e-07 4.282e-05
84 POSITIVE REGULATION OF GROWTH 9 238 8.534e-07 4.727e-05
85 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 7 121 9.013e-07 4.934e-05
86 CELL PROLIFERATION 14 672 9.915e-07 5.303e-05
87 REGULATION OF HEART GROWTH 5 42 9.809e-07 5.303e-05
88 RESPONSE TO BIOTIC STIMULUS 16 886 1.011e-06 5.344e-05
89 REGULATION OF MAP KINASE ACTIVITY 10 319 1.122e-06 5.868e-05
90 POSITIVE REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 4 19 1.176e-06 6.078e-05
91 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 21 1517 1.256e-06 6.421e-05
92 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 22 1656 1.309e-06 6.621e-05
93 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 7 129 1.388e-06 6.87e-05
94 PEPTIDYL TYROSINE MODIFICATION 8 186 1.375e-06 6.87e-05
95 REGULATION OF LIPASE ACTIVITY 6 83 1.534e-06 7.513e-05
96 POSITIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 6 84 1.646e-06 7.618e-05
97 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 17 1036 1.647e-06 7.618e-05
98 B CELL ACTIVATION 7 132 1.619e-06 7.618e-05
99 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 17 1036 1.647e-06 7.618e-05
100 POSITIVE REGULATION OF NF KAPPAB TRANSCRIPTION FACTOR ACTIVITY 7 132 1.619e-06 7.618e-05
101 CELLULAR RESPONSE TO NITROGEN COMPOUND 12 505 1.654e-06 7.618e-05
102 PROTEIN AUTOPHOSPHORYLATION 8 192 1.745e-06 7.96e-05
103 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 6 85 1.765e-06 7.975e-05
104 POSITIVE REGULATION OF CELL PROLIFERATION 15 814 1.8e-06 8.051e-05
105 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 12 513 1.946e-06 8.625e-05
106 RESPONSE TO CYTOKINE 14 714 2.022e-06 8.875e-05
107 POSITIVE REGULATION OF CELL DIFFERENTIATION 15 823 2.061e-06 8.962e-05
108 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 7 138 2.181e-06 9.395e-05
109 ORGAN MORPHOGENESIS 15 841 2.688e-06 0.0001147
110 POSITIVE REGULATION OF MAP KINASE ACTIVITY 8 207 3.056e-06 0.0001285
111 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 14 740 3.064e-06 0.0001285
112 POSITIVE REGULATION OF PHOSPHOLIPASE ACTIVITY 5 53 3.189e-06 0.0001325
113 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 9 282 3.453e-06 0.0001422
114 REGULATION OF BINDING 9 283 3.554e-06 0.0001451
115 CYTOKINE MEDIATED SIGNALING PATHWAY 11 452 3.706e-06 0.0001499
116 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 15 867 3.897e-06 0.0001525
117 INFLAMMATORY RESPONSE 11 454 3.866e-06 0.0001525
118 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 20 1492 3.9e-06 0.0001525
119 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 16 983 3.881e-06 0.0001525
120 MYELOID LEUKOCYTE ACTIVATION 6 98 4.064e-06 0.0001576
121 REGULATION OF DEVELOPMENTAL GROWTH 9 289 4.215e-06 0.0001595
122 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 9 289 4.215e-06 0.0001595
123 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 5 56 4.201e-06 0.0001595
124 LIPID PHOSPHORYLATION 6 99 4.311e-06 0.0001618
125 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 8 218 4.483e-06 0.0001669
126 REGULATION OF MAPK CASCADE 13 660 4.649e-06 0.0001717
127 HEART DEVELOPMENT 11 466 4.956e-06 0.0001816
128 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 9 296 5.118e-06 0.000186
129 EXCITATORY POSTSYNAPTIC POTENTIAL 4 27 5.185e-06 0.000187
130 POSITIVE REGULATION OF MAPK CASCADE 11 470 5.375e-06 0.000192
131 RHYTHMIC PROCESS 9 298 5.405e-06 0.000192
132 REGULATION OF INTERLEUKIN 6 PRODUCTION 6 104 5.739e-06 0.0002023
133 POSITIVE REGULATION OF CELL COMMUNICATION 20 1532 5.811e-06 0.0002033
134 RESPONSE TO GROWTH FACTOR 11 475 5.942e-06 0.0002063
135 POSITIVE REGULATION OF KINASE ACTIVITY 11 482 6.823e-06 0.0002335
136 REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 4 29 6.972e-06 0.0002335
137 POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 4 29 6.972e-06 0.0002335
138 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 62 6.975e-06 0.0002335
139 REGULATION OF PROTEIN TARGETING 9 307 6.871e-06 0.0002335
140 IMMUNE SYSTEM DEVELOPMENT 12 582 7.076e-06 0.0002352
141 GLAND DEVELOPMENT 10 395 7.505e-06 0.0002477
142 MORPHOGENESIS OF A BRANCHING STRUCTURE 7 167 7.704e-06 0.0002525
143 REGULATION OF PROTEIN ACETYLATION 5 64 8.163e-06 0.0002656
144 MUSCLE CELL DIFFERENTIATION 8 237 8.275e-06 0.0002674
145 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 10 404 9.135e-06 0.0002931
146 POSITIVE REGULATION OF LIPASE ACTIVITY 5 66 9.504e-06 0.0003029
147 CELLULAR RESPONSE TO ALCOHOL 6 115 1.025e-05 0.0003244
148 RESPONSE TO CORTICOSTEROID 7 176 1.086e-05 0.0003413
149 POSITIVE REGULATION OF INTERLEUKIN 6 PRODUCTION 5 68 1.101e-05 0.0003439
150 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 14 829 1.121e-05 0.0003477
151 NEGATIVE REGULATION OF KINASE ACTIVITY 8 250 1.22e-05 0.0003711
152 CELL MOTILITY 14 835 1.216e-05 0.0003711
153 LOCALIZATION OF CELL 14 835 1.216e-05 0.0003711
154 LYMPHOID PROGENITOR CELL DIFFERENTIATION 3 11 1.235e-05 0.0003733
155 COGNITION 8 251 1.256e-05 0.000374
156 POSITIVE REGULATION OF TYPE I INTERFERON PRODUCTION 5 70 1.27e-05 0.000374
157 I KAPPAB KINASE NF KAPPAB SIGNALING 5 70 1.27e-05 0.000374
158 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 13 724 1.254e-05 0.000374
159 NEGATIVE REGULATION OF PHOSPHORYLATION 10 422 1.333e-05 0.0003902
160 REGULATION OF PROTEIN IMPORT 7 183 1.399e-05 0.0004068
161 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 8 258 1.532e-05 0.0004429
162 REGULATION OF CELL PROLIFERATION 19 1496 1.546e-05 0.000444
163 RESPONSE TO BACTERIUM 11 528 1.601e-05 0.000457
164 DEFENSE RESPONSE 17 1231 1.627e-05 0.0004601
165 MUSCLE STRUCTURE DEVELOPMENT 10 432 1.632e-05 0.0004601
166 I KAPPAB PHOSPHORYLATION 3 12 1.642e-05 0.0004603
167 TISSUE MORPHOGENESIS 11 533 1.747e-05 0.0004867
168 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 7 193 1.973e-05 0.0005405
169 PROTEIN ACETYLATION 6 129 1.975e-05 0.0005405
170 NEGATIVE REGULATION OF CELL DEATH 14 872 1.972e-05 0.0005405
171 CELL DEATH 15 1001 2.159e-05 0.0005875
172 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 16 1135 2.341e-05 0.0006334
173 RESPONSE TO ALCOHOL 9 362 2.546e-05 0.0006849
174 DEVELOPMENTAL PIGMENTATION 4 40 2.588e-05 0.000692
175 TOLL LIKE RECEPTOR 9 SIGNALING PATHWAY 3 14 2.7e-05 0.0007179
176 RESPONSE TO ABIOTIC STIMULUS 15 1024 2.812e-05 0.0007433
177 REGULATION OF LIPID METABOLIC PROCESS 8 282 2.899e-05 0.0007622
178 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 9 370 3.021e-05 0.0007898
179 N TERMINAL PROTEIN AMINO ACID ACETYLATION 3 15 3.365e-05 0.0008746
180 POSITIVE REGULATION OF B CELL ACTIVATION 5 86 3.462e-05 0.000895
181 REGULATION OF JAK STAT CASCADE 6 144 3.675e-05 0.0009396
182 REGULATION OF STAT CASCADE 6 144 3.675e-05 0.0009396
183 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 9 381 3.796e-05 0.0009652
184 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 14 926 3.819e-05 0.0009658
185 B CELL DIFFERENTIATION 5 89 4.085e-05 0.001022
186 REGULATION OF CYTOPLASMIC TRANSPORT 10 481 4.072e-05 0.001022
187 CALCIUM MEDIATED SIGNALING 5 90 4.311e-05 0.001061
188 RESPONSE TO ESTROGEN 7 218 4.3e-05 0.001061
189 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 7 218 4.3e-05 0.001061
190 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 7 220 4.557e-05 0.001116
191 HOMEOSTATIC PROCESS 17 1337 4.656e-05 0.001134
192 EPITHELIUM DEVELOPMENT 14 945 4.762e-05 0.001154
193 CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 3 17 4.997e-05 0.001205
194 REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 5 94 5.312e-05 0.001274
195 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 4 48 5.367e-05 0.001281
196 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 10 498 5.449e-05 0.001294
197 MORPHOGENESIS OF AN EPITHELIUM 9 400 5.531e-05 0.001306
198 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 15 1087 5.575e-05 0.00131
199 CELLULAR RESPONSE TO CYTOKINE STIMULUS 11 606 5.631e-05 0.001317
200 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 4 49 5.825e-05 0.001348
201 POSITIVE REGULATION OF CHEMOKINE PRODUCTION 4 49 5.825e-05 0.001348
202 MYELOID LEUKOCYTE DIFFERENTIATION 5 96 5.876e-05 0.001353
203 GLAND MORPHOGENESIS 5 97 6.174e-05 0.001408
204 HORMONE MEDIATED SIGNALING PATHWAY 6 158 6.171e-05 0.001408
205 REGULATION OF SKELETAL MUSCLE TISSUE DEVELOPMENT 4 50 6.311e-05 0.001432
206 PROTEIN ACYLATION 6 159 6.391e-05 0.001444
207 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 11 616 6.521e-05 0.001458
208 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 11 616 6.521e-05 0.001458
209 REGULATION OF VASCULATURE DEVELOPMENT 7 233 6.547e-05 0.001458
210 VENTRICULAR CARDIAC MUSCLE CELL DIFFERENTIATION 3 19 7.077e-05 0.001561
211 PLATELET MORPHOGENESIS 3 19 7.077e-05 0.001561
212 CELLULAR RESPONSE TO BIOTIC STIMULUS 6 163 7.335e-05 0.001602
213 LOCOMOTION 15 1114 7.357e-05 0.001602
214 POSITIVE REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 4 52 7.37e-05 0.001602
215 REGULATION OF GROWTH 11 633 8.312e-05 0.001791
216 MELANOCYTE DIFFERENTIATION 3 20 8.3e-05 0.001791
217 NEUROGENESIS 17 1402 8.394e-05 0.0018
218 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 6 168 8.668e-05 0.00185
219 NEURON DIFFERENTIATION 13 874 8.786e-05 0.001867
220 REGULATION OF POSTSYNAPTIC MEMBRANE POTENTIAL 4 55 9.194e-05 0.001945
221 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 16 1275 9.421e-05 0.001977
222 RESPONSE TO VIRUS 7 247 9.435e-05 0.001977
223 STRIATED MUSCLE CELL DIFFERENTIATION 6 173 0.0001019 0.002126
224 CHROMATIN MODIFICATION 10 539 0.0001049 0.00218
225 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 10 541 0.0001082 0.002224
226 HOMEOSTASIS OF NUMBER OF CELLS 6 175 0.0001085 0.002224
227 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 10 541 0.0001082 0.002224
228 CELLULAR RESPONSE TO CORTICOSTEROID STIMULUS 4 58 0.0001133 0.002301
229 POSITIVE REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 4 58 0.0001133 0.002301
230 REGULATION OF TYPE I INTERFERON PRODUCTION 5 111 0.0001171 0.00237
231 COVALENT CHROMATIN MODIFICATION 8 345 0.0001191 0.002399
232 OVULATION CYCLE 5 113 0.0001274 0.002525
233 TUBE DEVELOPMENT 10 552 0.0001275 0.002525
234 POSITIVE REGULATION OF INFLAMMATORY RESPONSE 5 113 0.0001274 0.002525
235 REGULATION OF CELLULAR PROTEIN LOCALIZATION 10 552 0.0001275 0.002525
236 LEUKOCYTE HOMEOSTASIS 4 60 0.0001293 0.00255
237 REGULATION OF ENDOTHELIAL CELL MIGRATION 5 114 0.0001328 0.002608
238 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 8 351 0.0001341 0.002621
239 CELLULAR LIPID METABOLIC PROCESS 13 913 0.0001359 0.002645
240 RESPONSE TO INTERLEUKIN 1 5 115 0.0001384 0.002672
241 RESPONSE TO CALCIUM ION 5 115 0.0001384 0.002672
242 SKELETAL SYSTEM DEVELOPMENT 9 455 0.0001472 0.002831
243 REGULATION OF CYTOKINE PRODUCTION 10 563 0.0001498 0.002867
244 NEUROEPITHELIAL CELL DIFFERENTIATION 4 63 0.0001564 0.002983
245 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 8 360 0.0001595 0.003029
246 MYELOID CELL DIFFERENTIATION 6 189 0.0001652 0.003125
247 CYTOKINE PRODUCTION 5 120 0.000169 0.003184
248 PHOSPHOLIPID METABOLIC PROCESS 8 364 0.000172 0.003226
249 REGULATION OF CHEMOKINE PRODUCTION 4 65 0.0001766 0.003275
250 REGULATION OF B CELL ACTIVATION 5 121 0.0001757 0.003275
251 REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 4 65 0.0001766 0.003275
252 MUSCLE TISSUE DEVELOPMENT 7 275 0.0001833 0.003384
253 VASCULATURE DEVELOPMENT 9 469 0.0001847 0.003396
254 N TERMINAL PROTEIN AMINO ACID MODIFICATION 3 26 0.0001858 0.003404
255 WOUND HEALING 9 470 0.0001876 0.003423
256 POSITIVE REGULATION OF CYTOKINE PRODUCTION 8 370 0.0001922 0.003493
257 INOSITOL LIPID MEDIATED SIGNALING 5 124 0.000197 0.003567
258 ACTIVATION OF PROTEIN KINASE ACTIVITY 7 279 0.0002002 0.00361
259 POSITIVE REGULATION OF NF KAPPAB IMPORT INTO NUCLEUS 3 27 0.0002084 0.003744
260 REGULATION OF NEUROLOGICAL SYSTEM PROCESS 4 68 0.0002104 0.003765
261 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 13 957 0.0002159 0.003848
262 REGULATION OF CELL ACTIVATION 9 484 0.0002332 0.004127
263 REGULATION OF SPROUTING ANGIOGENESIS 3 28 0.0002327 0.004127
264 NEGATIVE REGULATION OF CATABOLIC PROCESS 6 203 0.0002432 0.004286
265 INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY 4 71 0.0002486 0.004348
266 CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN CELL CELL SIGNALING 4 71 0.0002486 0.004348
267 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 5 131 0.0002543 0.004432
268 PIGMENT CELL DIFFERENTIATION 3 29 0.0002587 0.004492
269 REGULATION OF LYMPHOCYTE DIFFERENTIATION 5 132 0.0002635 0.004557
270 EPITHELIAL CELL DIFFERENTIATION 9 495 0.0002753 0.004744
271 POSITIVE REGULATION OF INTERFERON BETA PRODUCTION 3 30 0.0002866 0.004902
272 CELLULAR RESPONSE TO ESTRADIOL STIMULUS 3 30 0.0002866 0.004902
273 LIPID MODIFICATION 6 210 0.0002918 0.004954
274 CARDIAC MUSCLE CELL DIFFERENTIATION 4 74 0.0002915 0.004954
275 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 7 297 0.0002928 0.004954
276 MACROPHAGE ACTIVATION 3 31 0.0003163 0.005332
277 REGULATION OF INTRACELLULAR TRANSPORT 10 621 0.0003286 0.00552
278 SALIVARY GLAND DEVELOPMENT 3 32 0.0003479 0.005802
279 POSITIVE REGULATION OF LIPID KINASE ACTIVITY 3 32 0.0003479 0.005802
280 REPRODUCTIVE SYSTEM DEVELOPMENT 8 408 0.0003709 0.006164
281 NEGATIVE REGULATION OF PROTEIN BINDING 4 79 0.0003745 0.006201
282 DENDRITIC CELL DIFFERENTIATION 3 33 0.0003815 0.006251
283 REGULATION OF WNT SIGNALING PATHWAY 7 310 0.000379 0.006251
284 RESPONSE TO DEXAMETHASONE 3 33 0.0003815 0.006251
285 PEPTIDYL LYSINE MODIFICATION 7 312 0.0003939 0.006409
286 POSITIVE REGULATION OF LYMPHOCYTE DIFFERENTIATION 4 80 0.0003929 0.006409
287 LIPID METABOLIC PROCESS 14 1158 0.0003989 0.006467
288 REGULATION OF RESPONSE TO WOUNDING 8 413 0.0004022 0.006498
289 REGULATION OF HEMOPOIESIS 7 314 0.0004093 0.00659
290 EMBRYO DEVELOPMENT 12 894 0.0004296 0.006892
291 PEPTIDYL SERINE MODIFICATION 5 148 0.0004462 0.007134
292 TELENCEPHALON DEVELOPMENT 6 228 0.000452 0.007203
293 RESPONSE TO MONOAMINE 3 35 0.0004548 0.007223
294 REGULATION OF CELLULAR COMPONENT MOVEMENT 11 771 0.0004569 0.007232
295 CELL PROJECTION ORGANIZATION 12 902 0.0004652 0.007337
296 TISSUE MIGRATION 4 84 0.0004732 0.007395
297 REGULATION OF ORGANELLE ORGANIZATION 14 1178 0.0004736 0.007395
298 POSITIVE REGULATION OF OSSIFICATION 4 84 0.0004732 0.007395
299 TUBE MORPHOGENESIS 7 323 0.0004845 0.007515
300 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 7 323 0.0004845 0.007515
301 REGULATION OF HYDROLASE ACTIVITY 15 1327 0.0004934 0.007596
302 CELL DIFFERENTIATION INVOLVED IN KIDNEY DEVELOPMENT 3 36 0.0004947 0.007596
303 OLFACTORY LOBE DEVELOPMENT 3 36 0.0004947 0.007596
304 REGULATION OF CHROMATIN ORGANIZATION 5 152 0.0005039 0.007713
305 PIGMENTATION 4 86 0.0005174 0.007867
306 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 4 86 0.0005174 0.007867
307 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 5 153 0.0005192 0.007869
308 CHROMATIN ORGANIZATION 10 663 0.0005488 0.00829
309 NEURON PROJECTION DEVELOPMENT 9 545 0.0005537 0.008338
310 BONE DEVELOPMENT 5 156 0.0005672 0.008458
311 OVULATION CYCLE PROCESS 4 88 0.0005644 0.008458
312 CELLULAR RESPONSE TO INORGANIC SUBSTANCE 5 156 0.0005672 0.008458
313 RESPONSE TO METAL ION 7 333 0.0005806 0.008632
314 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 8 437 0.0005837 0.00865
315 EPITHELIAL CELL PROLIFERATION 4 89 0.0005891 0.008701
316 REGULATION OF CELL MORPHOGENESIS 9 552 0.0006067 0.008933
317 REGULATION OF OXIDOREDUCTASE ACTIVITY 4 90 0.0006145 0.009019
318 REGULATION OF NEURON DIFFERENTIATION 9 554 0.0006225 0.009109
319 NEGATIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 3 39 0.0006273 0.00915
320 SECOND MESSENGER MEDIATED SIGNALING 5 160 0.0006362 0.00925
321 POSITIVE REGULATION OF RESPONSE TO WOUNDING 5 162 0.0006729 0.009754
322 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 3 40 0.0006761 0.009769
NumGOOverlapSizeP ValueAdj. P Value
1 MACROMOLECULAR COMPLEX BINDING 27 1399 1.443e-11 1.34e-08
2 TRANSCRIPTION FACTOR BINDING 15 524 6.073e-09 1.88e-06
3 CHROMATIN BINDING 14 435 4.695e-09 1.88e-06
4 PROTEIN KINASE ACTIVITY 15 640 8.53e-08 1.402e-05
5 KINASE ACTIVITY 17 842 9.057e-08 1.402e-05
6 PROTEIN COMPLEX BINDING 18 935 7.292e-08 1.402e-05
7 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 11 315 1.064e-07 1.412e-05
8 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 18 992 1.765e-07 2.05e-05
9 PROTEIN DIMERIZATION ACTIVITY 19 1149 3.175e-07 2.95e-05
10 GLUCOCORTICOID RECEPTOR BINDING 4 14 3.086e-07 2.95e-05
11 REGULATORY REGION NUCLEIC ACID BINDING 16 818 3.508e-07 2.963e-05
12 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 9 226 5.54e-07 3.697e-05
13 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 6 70 5.572e-07 3.697e-05
14 CORE PROMOTER PROXIMAL REGION DNA BINDING 11 371 5.443e-07 3.697e-05
15 DOUBLE STRANDED DNA BINDING 15 764 8.18e-07 5.066e-05
16 PROTEIN TYROSINE KINASE ACTIVITY 8 176 9.071e-07 5.267e-05
17 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 10 328 1.442e-06 7.882e-05
18 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 13 629 2.752e-06 0.000142
19 RECEPTOR BINDING 20 1476 3.311e-06 0.0001619
20 ADENYL NUCLEOTIDE BINDING 20 1514 4.865e-06 0.000226
21 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 6 104 5.739e-06 0.0002539
22 HISTONE DEACETYLASE BINDING 6 105 6.066e-06 0.0002561
23 SEQUENCE SPECIFIC DNA BINDING 16 1037 7.643e-06 0.0003087
24 RIBONUCLEOTIDE BINDING 22 1860 8.74e-06 0.0003383
25 PEPTIDE N ACETYLTRANSFERASE ACTIVITY 5 67 1.024e-05 0.0003804
26 RNA BINDING 20 1598 1.089e-05 0.000389
27 STEROID HORMONE RECEPTOR BINDING 5 81 2.591e-05 0.0008913
28 ENZYME BINDING 20 1737 3.654e-05 0.001173
29 N ACETYLTRANSFERASE ACTIVITY 5 87 3.661e-05 0.001173
30 TRANSCRIPTION COACTIVATOR ACTIVITY 8 296 4.089e-05 0.001266
31 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 11 588 4.291e-05 0.001286
32 CORE PROMOTER BINDING 6 152 4.974e-05 0.001444
33 CORE PROMOTER SEQUENCE SPECIFIC DNA BINDING 5 101 7.487e-05 0.002108
34 ACETYLTRANSFERASE ACTIVITY 5 103 8.219e-05 0.002246
35 N ACYLTRANSFERASE ACTIVITY 5 104 8.606e-05 0.002284
36 ACTIVATING TRANSCRIPTION FACTOR BINDING 4 57 0.0001058 0.00273
37 SIGNAL TRANSDUCER ACTIVITY 19 1731 0.0001133 0.002845
38 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 4 64 0.0001663 0.003964
39 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 15 1199 0.0001664 0.003964
40 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 3 26 0.0001858 0.004315
41 HISTONE ACETYLTRANSFERASE BINDING 3 28 0.0002327 0.005272
42 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 4 81 0.000412 0.009113
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 cGMP_PKG_signaling_pathway_hsa04022 6 163 7.335e-05 0.003254
2 cAMP_signaling_pathway_hsa04024 6 198 0.0002126 0.003254
3 Adherens_junction_hsa04520 4 72 0.0002624 0.003254
4 MAPK_signaling_pathway_hsa04010 7 295 0.0002811 0.003254
5 Apelin_signaling_pathway_hsa04371 5 137 0.0003129 0.003254
6 Jak_STAT_signaling_pathway_hsa04630 5 162 0.0006729 0.005832
7 PI3K_Akt_signaling_pathway_hsa04151 7 352 0.0008048 0.005933
8 HIF_1_signaling_pathway_hsa04066 4 100 0.0009128 0.005933
9 Notch_signaling_pathway_hsa04330 3 48 0.001155 0.006671
10 Regulation_of_actin_cytoskeleton_hsa04810 5 208 0.002041 0.01062
11 FoxO_signaling_pathway_hsa04068 4 132 0.002535 0.01198
12 Ras_signaling_pathway_hsa04014 5 232 0.00327 0.01417
13 Wnt_signaling_pathway_hsa04310 4 146 0.003642 0.01457
14 Cellular_senescence_hsa04218 4 160 0.005038 0.01871
15 TGF_beta_signaling_pathway_hsa04350 3 84 0.005692 0.01912
16 ErbB_signaling_pathway_hsa04012 3 85 0.005882 0.01912
17 Calcium_signaling_pathway_hsa04020 4 182 0.007893 0.02414
18 Rap1_signaling_pathway_hsa04015 4 206 0.01204 0.03478
19 Cytokine_cytokine_receptor_interaction_hsa04060 4 270 0.02915 0.07977
20 Gap_junction_hsa04540 2 88 0.05515 0.1434
21 Cell_cycle_hsa04110 2 124 0.09966 0.2468
22 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.1204 0.2722
23 Phospholipase_D_signaling_pathway_hsa04072 2 146 0.1304 0.2825
24 Phagosome_hsa04145 2 152 0.1391 0.2894
25 Tight_junction_hsa04530 2 170 0.166 0.3321
26 Endocytosis_hsa04144 2 244 0.2825 0.5065
27 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.3363 0.5469

Quest ID: 6669e8086582771f04f1f1c7d2bbdae0