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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-148a-3p A4GNT -0.75 0 -1.24 0.00042 MirTarget -0.73 0 NA
2 hsa-miR-148a-3p ACHE -0.75 0 0.07 0.84522 miRNATAP -0.64 0 NA
3 hsa-miR-148a-3p ACSL4 -0.75 0 2.07 0 miRNATAP -0.65 0 NA
4 hsa-miR-148a-3p ACVR1 -0.75 0 -0.44 1.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.13 0.0001 NA
5 hsa-miR-148a-3p ADAM10 -0.75 0 -0 0.9783 MirTarget -0.11 0.02275 NA
6 hsa-miR-148a-3p ADAM19 -0.75 0 -0.32 0.02321 mirMAP -0.33 0 NA
7 hsa-miR-148a-3p ADAM22 -0.75 0 1.17 0.00038 MirTarget; miRNATAP -0.57 0 NA
8 hsa-miR-148a-3p ADAM23 -0.75 0 1.53 0.00013 MirTarget -0.47 0.00032 NA
9 hsa-miR-148a-3p ADAMTS15 -0.75 0 -0.88 0.00206 MirTarget; miRNATAP -0.41 1.0E-5 NA
10 hsa-miR-148a-3p ADAMTS18 -0.75 0 1.44 1.0E-5 miRNATAP -0.21 0.04667 NA
11 hsa-miR-148a-3p ADAMTS5 -0.75 0 -0.16 0.36499 miRNATAP -0.31 0 NA
12 hsa-miR-148a-3p ADM2 -0.75 0 1.72 0 mirMAP -0.43 0 NA
13 hsa-miR-148a-3p ADPRH -0.75 0 -0.13 0.2674 MirTarget -0.25 0 NA
14 hsa-miR-148a-3p AHDC1 -0.75 0 -0.23 0.02626 miRNATAP -0.12 0.00053 NA
15 hsa-miR-148a-3p AMZ1 -0.75 0 -1.28 0.00014 mirMAP -0.44 6.0E-5 NA
16 hsa-miR-148a-3p ANK2 -0.75 0 -0.94 8.0E-5 MirTarget; miRNATAP -0.44 0 NA
17 hsa-miR-148a-3p ANKRD27 -0.75 0 0.9 0 mirMAP -0.18 0 NA
18 hsa-miR-148a-3p ANKRD52 -0.75 0 1.46 0 mirMAP; miRNATAP -0.25 0 NA
19 hsa-miR-148a-3p ANKS6 -0.75 0 0.76 0.01521 mirMAP -0.63 0 NA
20 hsa-miR-148a-3p ANXA4 -0.75 0 -0.2 0.167 MirTarget -0.36 0 NA
21 hsa-miR-148a-3p ARAP2 -0.75 0 -1.13 0 MirTarget -0.26 0 NA
22 hsa-miR-148a-3p ARHGEF17 -0.75 0 0.06 0.69914 miRNATAP -0.46 0 NA
23 hsa-miR-148a-3p ATG4D -0.75 0 0.24 0.03588 MirTarget -0.18 0 NA
24 hsa-miR-148a-3p ATP11A -0.75 0 0.19 0.15998 MirTarget -0.17 0.00011 NA
25 hsa-miR-148a-3p ATP2B4 -0.75 0 0.27 0.06736 MirTarget; miRNATAP -0.11 0.02111 NA
26 hsa-miR-148a-3p ATP7A -0.75 0 0.25 0.01885 MirTarget; miRNATAP -0.12 0.00074 NA
27 hsa-miR-148a-3p AURKB -0.75 0 3.49 0 miRNAWalker2 validate -0.53 0 NA
28 hsa-miR-148a-3p B4GALT2 -0.75 0 0.26 0.00786 miRNATAP -0.13 3.0E-5 NA
29 hsa-miR-148a-3p B4GALT5 -0.75 0 -0.52 0 MirTarget; miRNATAP -0.33 0 NA
30 hsa-miR-148a-3p BAZ2A -0.75 0 0.46 0 mirMAP; miRNATAP -0.15 0 NA
31 hsa-miR-148a-3p BCL2 -0.75 0 -0.35 0.02497 miRNAWalker2 validate; miRTarBase -0.31 0 21455217; 23975374 MiR 148a promotes apoptosis by targeting Bcl 2 in colorectal cancer;MiR 148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl 2; Using western blot and luciferase activity assay CCKBR and Bcl-2 were identified as targets of miR-148a; Moreover we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a
32 hsa-miR-148a-3p BCL9L -0.75 0 0.49 7.0E-5 mirMAP -0.25 0 NA
33 hsa-miR-148a-3p BHLHE41 -0.75 0 -0.4 0.15906 MirTarget -0.82 0 NA
34 hsa-miR-148a-3p BMF -0.75 0 0.48 0.01823 mirMAP -0.31 0 NA
35 hsa-miR-148a-3p BTBD10 -0.75 0 0.28 2.0E-5 MirTarget; miRNATAP -0.17 0 NA
36 hsa-miR-148a-3p BTBD3 -0.75 0 0.3 0.00861 miRNAWalker2 validate; miRNATAP -0.17 1.0E-5 NA
37 hsa-miR-148a-3p C1orf116 -0.75 0 -1.07 0.0053 mirMAP -0.61 0 NA
38 hsa-miR-148a-3p C5orf30 -0.75 0 0.91 0.00049 miRNATAP -0.74 0 NA
39 hsa-miR-148a-3p CACNA1E -0.75 0 1.61 4.0E-5 mirMAP -0.55 2.0E-5 NA
40 hsa-miR-148a-3p CASZ1 -0.75 0 0.04 0.75925 miRNATAP -0.22 0 NA
41 hsa-miR-148a-3p CBFA2T2 -0.75 0 1.21 0 mirMAP -0.14 8.0E-5 NA
42 hsa-miR-148a-3p CBX5 -0.75 0 0.35 0.00158 mirMAP -0.15 2.0E-5 NA
43 hsa-miR-148a-3p CCDC6 -0.75 0 0.05 0.48713 MirTarget -0.16 0 NA
44 hsa-miR-148a-3p CCDC85A -0.75 0 0.74 9.0E-5 miRNATAP -0.16 0.00895 NA
45 hsa-miR-148a-3p CCT6A -0.75 0 0.81 0 MirTarget -0.14 0 NA
46 hsa-miR-148a-3p CDC25B -0.75 0 0.8 0 miRNAWalker2 validate; miRNATAP -0.29 0 25341915 Gene CDC25B might be the target gene of miR-148a according to the results of targetscan; CDC25B may be the target gene of miR-148a that plays a role in tumor suppressor
47 hsa-miR-148a-3p CDK19 -0.75 0 0.12 0.29406 miRNAWalker2 validate; MirTarget; miRNATAP -0.24 0 NA
48 hsa-miR-148a-3p CDK5R1 -0.75 0 1.08 0 MirTarget; miRNATAP -0.17 0.00187 NA
49 hsa-miR-148a-3p CDS1 -0.75 0 -0.32 0.40167 miRNATAP -0.62 0 NA
50 hsa-miR-148a-3p CELSR1 -0.75 0 0.36 0.10713 MirTarget -0.21 0.00487 NA
51 hsa-miR-148a-3p CENPP -0.75 0 1.59 0 mirMAP -0.15 0.0069 NA
52 hsa-miR-148a-3p CEP55 -0.75 0 2.87 0 MirTarget -0.76 0 NA
53 hsa-miR-148a-3p CHST1 -0.75 0 0.69 0.00199 MirTarget -0.73 0 NA
54 hsa-miR-148a-3p CHST3 -0.75 0 -0.2 0.3013 mirMAP -0.54 0 NA
55 hsa-miR-148a-3p CIITA -0.75 0 0.27 0.18011 mirMAP -0.26 5.0E-5 NA
56 hsa-miR-148a-3p CIT -0.75 0 0.47 0.00991 miRNATAP -0.15 0.0119 NA
57 hsa-miR-148a-3p CNIH4 -0.75 0 1.01 0 MirTarget -0.1 0.00643 NA
58 hsa-miR-148a-3p CNN1 -0.75 0 0.41 0.09282 miRNATAP -0.5 0 NA
59 hsa-miR-148a-3p CNTN4 -0.75 0 -2.24 0 miRNATAP -0.27 0.00181 NA
60 hsa-miR-148a-3p COL4A1 -0.75 0 1.65 0 miRNATAP -0.51 0 NA
61 hsa-miR-148a-3p CPD -0.75 0 0.6 0 MirTarget; miRNATAP -0.14 0.00104 NA
62 hsa-miR-148a-3p CS -0.75 0 0.63 0 miRNATAP -0.15 0 NA
63 hsa-miR-148a-3p CSF1 -0.75 0 -0.59 0.00153 miRNATAP -0.26 2.0E-5 NA
64 hsa-miR-148a-3p CSPG4 -0.75 0 2.21 0 miRNATAP -0.47 0 NA
65 hsa-miR-148a-3p CTTNBP2NL -0.75 0 0.03 0.8194 MirTarget; miRNATAP -0.4 0 NA
66 hsa-miR-148a-3p CYTH3 -0.75 0 0.61 0 MirTarget; miRNATAP -0.29 0 NA
67 hsa-miR-148a-3p DMPK -0.75 0 0.66 0 MirTarget -0.31 0 NA
68 hsa-miR-148a-3p DNAJC18 -0.75 0 0.38 0.00786 MirTarget -0.48 0 NA
69 hsa-miR-148a-3p DNER -0.75 0 1.29 0.00336 MirTarget; miRNATAP -1.04 0 NA
70 hsa-miR-148a-3p DNMT1 -0.75 0 1.07 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.22 0 25865490; 26111756; 25950085; 22167392 miR 148a dependent apoptosis of bladder cancer cells is mediated in part by the epigenetic modifier DNMT1; We additionally show that miR-148a exerts this effect partially by attenuating expression of DNA methyltransferase 1 DNMT1;Moreover we found that miR-148a appeared to be a target of bufalin and miR-148a further regulated DNMT1 and p27 to control the stemness of OS cells;The Interplay Between miR 148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy; We discovered the expression level of miR-148a significantly decreased in pancreatic cancer tissues whereas that of DNMT1 increased; In ASPC-1 cancer cells the overexpression of miR-148a led to a decreased level of DNMT1 and reduced the proliferation and metastasis of ASPC-1 cells; Interestingly it was shown that the DNMT1 inhibition enhanced the expression of miR-148a; In vivo studies demonstrated that the tumorigenesis of ASPC-1 was significantly arrested by either the overexpression of miR-148a or the inhibition of DNMT1;Studies have shown that microRNA-148a miR-148a was proved to be silenced while DNA methyltransferase 1 DNMT1 was over-expressed in gastric cancer; But the mechanism of aberrant expression of miR-148a and DNMT1 and their relationships in gastric cancer are still unknown; The aims of this study were to investigate the expression profile of miR-148a and DNMT1 and reveal whether they have any relationships; We used reverse-transcriptase quantitative real-time PCR methylation-specific PCR and Western blot to measure the level of miR-148a expression DNA methylation level and DNMT1 expression respectively; DNMT1 was over-expressed in primary tumors and cell lines while knockdown of DNMT1 using siRNA could decrease methylation level of miR-148a promoter and restore its expression; Furthermore ectopic over-expression of miR-148a in cancer cell lines caused reduction in DNMT1 expression and inhibited cell proliferation but no obvious change was found in apoptosis rate; These results suggest that miR-148a is inactivated by DNA hypermethylation of promoter region in gastric cancer which is mediated through DNMT1 over-expression; Additionally the silence of miR-148a reduces its suppression to DNMT1 in gastric cancer and this may in turn result in over-expression of DNMT1 and promote DNA hypermethylation
71 hsa-miR-148a-3p DNMT3B -0.75 0 1.62 0 miRNAWalker2 validate; miRTarBase -0.19 0.00195 20841507 Low ERG expressers presented with down-regulation of genes involved in the DNA-methylation machinery and up-regulation of miR-148a which targets DNMT3B
72 hsa-miR-148a-3p DOCK3 -0.75 0 1.9 0 miRNATAP -0.28 0.00024 NA
73 hsa-miR-148a-3p DOCK6 -0.75 0 0.92 0 MirTarget -0.24 0 NA
74 hsa-miR-148a-3p DOT1L -0.75 0 0.59 0 mirMAP -0.11 0.0049 NA
75 hsa-miR-148a-3p DPP3 -0.75 0 0.37 1.0E-5 miRNATAP -0.13 0 NA
76 hsa-miR-148a-3p DSTYK -0.75 0 1.01 0 miRNAWalker2 validate -0.2 0 NA
77 hsa-miR-148a-3p DTNA -0.75 0 1.85 0 miRNATAP -0.42 1.0E-5 NA
78 hsa-miR-148a-3p DYRK1B -0.75 0 0.43 0.00067 miRNATAP -0.23 0 NA
79 hsa-miR-148a-3p E2F3 -0.75 0 0.68 0 miRNATAP -0.29 0 NA
80 hsa-miR-148a-3p E2F7 -0.75 0 3.07 0 miRNATAP -0.24 0.00995 NA
81 hsa-miR-148a-3p EFNB2 -0.75 0 0.1 0.47703 MirTarget; miRNATAP -0.19 4.0E-5 NA
82 hsa-miR-148a-3p EGR3 -0.75 0 -2.49 0 MirTarget -0.21 0.01299 NA
83 hsa-miR-148a-3p ELFN2 -0.75 0 2.87 0 mirMAP -0.48 0.00248 NA
84 hsa-miR-148a-3p ENTPD1 -0.75 0 0.55 0 mirMAP -0.3 0 NA
85 hsa-miR-148a-3p EPB41L1 -0.75 0 0.13 0.60566 MirTarget -0.3 0.00034 NA
86 hsa-miR-148a-3p EPN2 -0.75 0 0.04 0.69334 MirTarget; miRNATAP -0.12 6.0E-5 NA
87 hsa-miR-148a-3p ERC2 -0.75 0 1.32 2.0E-5 MirTarget -0.31 0.00232 NA
88 hsa-miR-148a-3p ERMP1 -0.75 0 0.54 1.0E-5 MirTarget -0.26 0 NA
89 hsa-miR-148a-3p ETV5 -0.75 0 -0.15 0.35537 MirTarget; miRNATAP -0.3 0 NA
90 hsa-miR-148a-3p F3 -0.75 0 -1.78 0 MirTarget -0.59 0 NA
91 hsa-miR-148a-3p FAM160B2 -0.75 0 0.17 0.05405 mirMAP -0.16 0 NA
92 hsa-miR-148a-3p FAM53B -0.75 0 0.97 0 mirMAP -0.29 0 NA
93 hsa-miR-148a-3p FBXL19 -0.75 0 1.09 0 miRNATAP -0.38 0 NA
94 hsa-miR-148a-3p FLOT2 -0.75 0 0.17 0.08391 MirTarget -0.14 3.0E-5 NA
95 hsa-miR-148a-3p FMNL3 -0.75 0 0.67 0 miRNATAP -0.45 0 NA
96 hsa-miR-148a-3p FOXF1 -0.75 0 -1.94 0 MirTarget -0.31 4.0E-5 NA
97 hsa-miR-148a-3p FOXK1 -0.75 0 1.2 0 mirMAP -0.28 0 NA
98 hsa-miR-148a-3p FOXK2 -0.75 0 0.56 0 miRNATAP -0.12 4.0E-5 NA
99 hsa-miR-148a-3p GAS1 -0.75 0 -2.01 0 miRNAWalker2 validate -0.45 0 NA
100 hsa-miR-148a-3p GDF6 -0.75 0 -2.1 0 miRNATAP -0.33 0.00152 NA
101 hsa-miR-148a-3p GLIPR2 -0.75 0 -0.26 0.12652 MirTarget -0.57 0 NA
102 hsa-miR-148a-3p GPRC5A -0.75 0 -1.99 0 MirTarget -0.65 0 NA
103 hsa-miR-148a-3p HAS3 -0.75 0 0.5 0.00069 miRNATAP -0.17 0.00044 NA
104 hsa-miR-148a-3p HOMER1 -0.75 0 -0.08 0.79615 MirTarget -0.67 0 NA
105 hsa-miR-148a-3p HOXC8 -0.75 0 0.89 0.00741 miRNAWalker2 validate; miRNATAP -0.32 0.00368 NA
106 hsa-miR-148a-3p IGDCC4 -0.75 0 1.73 0 miRNATAP -1.1 0 NA
107 hsa-miR-148a-3p IL15 -0.75 0 -0.3 0.13357 MirTarget -0.36 0 NA
108 hsa-miR-148a-3p IL17RD -0.75 0 -0.13 0.6098 miRNATAP -0.83 0 NA
109 hsa-miR-148a-3p IQCE -0.75 0 1.21 0 mirMAP -0.3 0 NA
110 hsa-miR-148a-3p ITGA5 -0.75 0 0.47 5.0E-5 miRNATAP -0.31 0 NA
111 hsa-miR-148a-3p ITGB8 -0.75 0 -2.87 0 miRNATAP -1.15 0 NA
112 hsa-miR-148a-3p KCTD2 -0.75 0 0.44 0 mirMAP -0.14 0 NA
113 hsa-miR-148a-3p KIAA0513 -0.75 0 0.68 0 mirMAP -0.25 0 NA
114 hsa-miR-148a-3p KIAA1324L -0.75 0 -0.5 0.07753 MirTarget; miRNATAP -0.43 0 NA
115 hsa-miR-148a-3p KIAA1549 -0.75 0 0.66 0.03559 miRNAWalker2 validate -0.33 0.0012 NA
116 hsa-miR-148a-3p KIAA1644 -0.75 0 -1.81 0 mirMAP -0.61 0 NA
117 hsa-miR-148a-3p KIF14 -0.75 0 2.98 0 MirTarget -0.35 3.0E-5 NA
118 hsa-miR-148a-3p KIF21B -0.75 0 1.18 0 mirMAP -0.28 0.00027 NA
119 hsa-miR-148a-3p KIF26B -0.75 0 0.15 0.64008 mirMAP -0.84 0 NA
120 hsa-miR-148a-3p KLC2 -0.75 0 1.16 0 miRNATAP -0.4 0 NA
121 hsa-miR-148a-3p KLF4 -0.75 0 -1.65 0 MirTarget; miRNATAP -0.23 0.00319 NA
122 hsa-miR-148a-3p KLHL17 -0.75 0 1.06 0 MirTarget -0.16 2.0E-5 NA
123 hsa-miR-148a-3p KLHL18 -0.75 0 0.14 0.02655 mirMAP; miRNATAP -0.1 0 NA
124 hsa-miR-148a-3p KLHL6 -0.75 0 -0.34 0.07564 mirMAP -0.36 0 NA
125 hsa-miR-148a-3p KSR2 -0.75 0 0.51 0.11076 mirMAP -0.48 0 NA
126 hsa-miR-148a-3p LENG8 -0.75 0 0.76 0 miRNATAP -0.18 0 NA
127 hsa-miR-148a-3p LMX1B -0.75 0 0.36 0.35128 mirMAP -0.83 0 NA
128 hsa-miR-148a-3p LONRF2 -0.75 0 -1.04 0.00952 mirMAP -0.68 0 NA
129 hsa-miR-148a-3p LRFN1 -0.75 0 0.25 0.27507 miRNATAP -0.51 0 NA
130 hsa-miR-148a-3p LRRC8B -0.75 0 -0.65 0.0004 mirMAP -0.44 0 NA
131 hsa-miR-148a-3p MAF1 -0.75 0 0.59 0 MirTarget; miRNATAP -0.2 0 NA
132 hsa-miR-148a-3p MAFG -0.75 0 1.2 0 MirTarget -0.17 0.00023 NA
133 hsa-miR-148a-3p MAP7D2 -0.75 0 0.76 0.08667 MirTarget -0.47 0.00133 NA
134 hsa-miR-148a-3p MARCH3 -0.75 0 0.62 0.00256 MirTarget; miRNATAP -0.62 0 NA
135 hsa-miR-148a-3p MATN3 -0.75 0 2.25 0 MirTarget -0.57 1.0E-5 NA
136 hsa-miR-148a-3p MBP -0.75 0 -0.4 0.00153 mirMAP -0.1 0.01407 NA
137 hsa-miR-148a-3p MECP2 -0.75 0 0.26 0.00043 miRNATAP -0.11 1.0E-5 NA
138 hsa-miR-148a-3p MGAT4A -0.75 0 0.1 0.34719 MirTarget; miRNATAP -0.19 0 NA
139 hsa-miR-148a-3p MITF -0.75 0 -0.41 0.01461 miRNATAP -0.47 0 20644734 miR 148 regulates Mitf in melanoma cells; Furthermore miR-148 was shown to affect Mitf mRNA expression in melanoma cells through a conserved binding site in the 3'UTR sequence of mouse and human Mitf; Our data show that miR-148 and miR-137 present an additional level of regulating Mitf expression in melanocytes and melanoma cells
140 hsa-miR-148a-3p MLLT6 -0.75 0 0.65 0 mirMAP -0.16 0 NA
141 hsa-miR-148a-3p MMD -0.75 0 -0.04 0.78978 miRNATAP -0.37 0 NA
142 hsa-miR-148a-3p MMP15 -0.75 0 -0.2 0.13063 MirTarget; miRNATAP -0.12 0.0054 NA
143 hsa-miR-148a-3p MNT -0.75 0 0.18 0.01893 MirTarget; miRNATAP -0.13 0 NA
144 hsa-miR-148a-3p MOSPD1 -0.75 0 0.49 0.00045 MirTarget; miRNATAP -0.13 0.00334 NA
145 hsa-miR-148a-3p MPP2 -0.75 0 0.36 0.19365 mirMAP -0.58 0 NA
146 hsa-miR-148a-3p MXRA7 -0.75 0 0.08 0.61015 mirMAP -0.33 0 NA
147 hsa-miR-148a-3p MYBL1 -0.75 0 1.15 0 miRNATAP -0.22 3.0E-5 NA
148 hsa-miR-148a-3p MYO5A -0.75 0 0.56 0.00049 mirMAP -0.35 0 NA
149 hsa-miR-148a-3p NAP1L1 -0.75 0 0.49 0 MirTarget -0.22 0 NA
150 hsa-miR-148a-3p NAT14 -0.75 0 0.76 2.0E-5 miRNATAP -0.46 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 56 1672 2.071e-10 9.636e-07
2 REGULATION OF CELL DIFFERENTIATION 51 1492 7.878e-10 1.833e-06
3 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 38 957 2.983e-09 4.627e-06
4 NEUROGENESIS 47 1402 7.604e-09 8.845e-06
5 CELL DEVELOPMENT 46 1426 3.616e-08 3.365e-05
6 TISSUE DEVELOPMENT 47 1518 8.621e-08 6.686e-05
7 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 38 1142 3.053e-07 0.0002016
8 CARDIOVASCULAR SYSTEM DEVELOPMENT 30 788 3.899e-07 0.0002016
9 CIRCULATORY SYSTEM DEVELOPMENT 30 788 3.899e-07 0.0002016
10 VASCULATURE DEVELOPMENT 22 469 5.165e-07 0.0002239
11 REGULATION OF CELL ADHESION 26 629 5.293e-07 0.0002239
12 ANGIOGENESIS 17 293 5.989e-07 0.0002322
13 BLOOD VESSEL MORPHOGENESIS 19 364 6.496e-07 0.0002325
14 TISSUE MORPHOGENESIS 23 533 1.195e-06 0.0003971
15 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 49 1784 1.547e-06 0.00048
16 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 41 1395 2.45e-06 0.0007124
17 MORPHOGENESIS OF AN EPITHELIUM 19 400 2.63e-06 0.00072
18 POSITIVE REGULATION OF CELL DIFFERENTIATION 29 823 2.889e-06 0.0007467
19 REGULATION OF CELL DEVELOPMENT 29 836 3.919e-06 0.0009596
20 PROTEIN PHOSPHORYLATION 31 944 5.433e-06 0.001264
21 NEURON PROJECTION DEVELOPMENT 22 545 5.996e-06 0.001329
22 POSITIVE REGULATION OF CELL DEVELOPMENT 20 472 7.933e-06 0.001678
23 REGULATION OF EPITHELIAL CELL PROLIFERATION 15 285 9.063e-06 0.001778
24 NEURON DIFFERENTIATION 29 874 9.17e-06 0.001778
25 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 32 1021 9.831e-06 0.00183
26 EPITHELIUM DEVELOPMENT 30 945 1.492e-05 0.00267
27 POSITIVE REGULATION OF GENE EXPRESSION 45 1733 1.863e-05 0.00321
28 POSITIVE REGULATION OF NEURON DIFFERENTIATION 15 306 2.097e-05 0.003484
29 SYNAPTIC SIGNALING 18 424 2.215e-05 0.003554
30 CENTRAL NERVOUS SYSTEM DEVELOPMENT 28 872 2.385e-05 0.0037
31 SPROUTING ANGIOGENESIS 6 45 3.125e-05 0.00469
32 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 25 750 3.634e-05 0.005284
33 NEURON PROJECTION MORPHOGENESIS 17 402 3.936e-05 0.00555
34 CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS 4 15 4.059e-05 0.005555
NumGOOverlapSizeP ValueAdj. P Value
1 METALLOPEPTIDASE ACTIVITY 13 188 1.898e-06 0.001764
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Ferroptosis_hsa04216 4 40 0.002081 0.1082
2 TGF_beta_signaling_pathway_hsa04350 5 84 0.005781 0.1503
3 HIF_1_signaling_pathway_hsa04066 4 100 0.04767 0.7158
4 Focal_adhesion_hsa04510 6 199 0.05506 0.7158
5 Cell_cycle_hsa04110 4 124 0.08922 0.7665
6 ECM_receptor_interaction_hsa04512 3 82 0.101 0.7665
7 Endocytosis_hsa04144 6 244 0.1167 0.7665
8 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 4 139 0.1217 0.7665
9 Hedgehog_signaling_pathway_hsa04340 2 47 0.134 0.7665
10 Hippo_signaling_pathway_hsa04390 4 154 0.1585 0.7665
11 cGMP_PKG_signaling_pathway_hsa04022 4 163 0.1822 0.7665
12 PI3K_Akt_signaling_pathway_hsa04151 7 352 0.2047 0.7665
13 Ras_signaling_pathway_hsa04014 5 232 0.2095 0.7665
14 MAPK_signaling_pathway_hsa04010 6 295 0.2145 0.7665
15 Mitophagy_animal_hsa04137 2 65 0.2213 0.7665
16 Calcium_signaling_pathway_hsa04020 4 182 0.2358 0.7665
17 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.3156 0.8777
18 Wnt_signaling_pathway_hsa04310 3 146 0.3194 0.8777
19 ErbB_signaling_pathway_hsa04012 2 85 0.3219 0.8777
20 Cellular_senescence_hsa04218 3 160 0.3713 0.8777
21 TNF_signaling_pathway_hsa04668 2 108 0.4332 0.9794
22 Cytokine_cytokine_receptor_interaction_hsa04060 4 270 0.5019 1
23 Autophagy_animal_hsa04140 2 128 0.5216 1
24 FoxO_signaling_pathway_hsa04068 2 132 0.5381 1
25 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.5397 1
26 Apelin_signaling_pathway_hsa04371 2 137 0.5583 1
27 Phospholipase_D_signaling_pathway_hsa04072 2 146 0.5929 1
28 Phagosome_hsa04145 2 152 0.6148 1
29 Jak_STAT_signaling_pathway_hsa04630 2 162 0.6494 1
30 cAMP_signaling_pathway_hsa04024 2 198 0.7537 1

Quest ID: 672185f55c50448badebffe1ac161f79