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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-877-5p ACTA1 1.98 0 -4.44 0 miRNAWalker2 validate -0.74 0 NA
2 hsa-let-7a-3p COL1A2 0.1 0.42376 2.67 0 MirTarget -0.31 0.00467 NA
3 hsa-let-7d-5p COL1A2 0.48 0 2.67 0 MirTarget; miRNATAP -0.32 0.0217 NA
4 hsa-let-7g-5p COL1A2 -0.25 0.0094 2.67 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.36 0.00882 NA
5 hsa-miR-193a-3p COL1A2 0.22 0.11183 2.67 0 miRanda -0.21 0.02795 NA
6 hsa-miR-19a-3p COL1A2 1.36 0 2.67 0 MirTarget -0.33 0 NA
7 hsa-miR-19b-3p COL1A2 0.54 0.00062 2.67 0 MirTarget -0.59 0 NA
8 hsa-miR-25-3p COL1A2 0.77 0 2.67 0 MirTarget; miRNATAP -0.35 0.00222 NA
9 hsa-miR-26a-5p COL1A2 -1.09 0 2.67 0 MirTarget; miRNATAP -0.37 0.00134 NA
10 hsa-miR-26b-5p COL1A2 -0.25 0.02852 2.67 0 MirTarget; miRNATAP -0.72 0 NA
11 hsa-miR-29a-3p COL1A2 -1.27 0 2.67 0 miRNATAP -0.62 0 NA
12 hsa-miR-29b-3p COL1A2 -0.11 0.51126 2.67 0 miRNATAP -0.66 0 NA
13 hsa-miR-29c-3p COL1A2 -2.08 0 2.67 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.5 0 NA
14 hsa-miR-30a-3p COL1A2 -2.26 0 2.67 0 MirTarget -0.19 0.00256 NA
15 hsa-miR-30d-3p COL1A2 -0.58 0 2.67 0 MirTarget -0.91 0 NA
16 hsa-miR-30e-3p COL1A2 -0.89 0 2.67 0 MirTarget -0.71 0 NA
17 hsa-miR-32-5p COL1A2 -0.32 0.01025 2.67 0 MirTarget; miRNATAP -0.73 0 NA
18 hsa-miR-33a-3p COL1A2 0.2 0.21234 2.67 0 MirTarget -0.51 0 NA
19 hsa-miR-342-3p COL1A2 1 0 2.67 0 miRanda; miRNATAP -0.19 0.01655 NA
20 hsa-miR-363-3p COL1A2 -0.61 0.01861 2.67 0 MirTarget -0.36 0 NA
21 hsa-miR-590-3p COL1A2 0.22 0.09659 2.67 0 miRanda -0.5 0 NA
22 hsa-miR-7-1-3p COL1A2 1.14 0 2.67 0 mirMAP -0.48 0 NA
23 hsa-miR-92a-3p COL1A2 0.99 0 2.67 0 MirTarget; miRNATAP -0.53 0 NA
24 hsa-miR-16-2-3p EMP1 1.16 0 -2.53 0 mirMAP -0.37 0 NA
25 hsa-miR-19b-1-5p EMP1 0.76 0 -2.53 0 MirTarget -0.25 0.00017 NA
26 hsa-miR-34a-5p EMP1 -0.12 0.364 -2.53 0 miRNAWalker2 validate -0.18 0.01968 NA
27 hsa-miR-361-3p EMP1 0.27 0.01479 -2.53 0 MirTarget -0.36 3.0E-5 NA
28 hsa-miR-429 EMP1 0.56 0.00564 -2.53 0 miRanda -0.11 0.01838 NA
29 hsa-miR-501-5p EMP1 1.03 0 -2.53 0 PITA -0.28 0 NA
30 hsa-miR-539-5p EMP1 -0.15 0.49255 -2.53 0 MirTarget -0.11 0.01741 NA
31 hsa-miR-590-3p EMP1 0.22 0.09659 -2.53 0 miRanda -0.21 0.00503 NA
32 hsa-miR-629-3p EMP1 1.43 0 -2.53 0 MirTarget -0.16 0.00637 NA
33 hsa-miR-708-3p EMP1 1.33 0 -2.53 0 MirTarget -0.16 0.00621 NA
34 hsa-miR-877-5p EMP1 1.98 0 -2.53 0 MirTarget -0.23 0 NA
35 hsa-miR-139-5p FN1 -1.46 0 2.78 0 miRanda -0.4 2.0E-5 NA
36 hsa-miR-144-3p FN1 -1.65 0 2.78 0 MirTarget -0.12 0.018 NA
37 hsa-miR-16-1-3p FN1 0.96 0 2.78 0 mirMAP -0.34 0.00058 NA
38 hsa-miR-200b-3p FN1 0.07 0.68286 2.78 0 miRNAWalker2 validate; miRTarBase; MirTarget; TargetScan -0.86 0 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b
39 hsa-miR-200c-3p FN1 0.63 0.00013 2.78 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.53 0 NA
40 hsa-miR-26b-5p FN1 -0.25 0.02852 2.78 0 miRNAWalker2 validate -0.7 0 NA
41 hsa-miR-27b-3p FN1 -0.73 0 2.78 0 MirTarget -0.93 0 NA
42 hsa-miR-33a-3p FN1 0.2 0.21234 2.78 0 mirMAP -0.51 0 NA
43 hsa-miR-429 FN1 0.56 0.00564 2.78 0 MirTarget; PITA; miRanda; miRNATAP -0.59 0 NA
44 hsa-miR-590-3p FN1 0.22 0.09659 2.78 0 miRanda; mirMAP -0.41 0.00021 NA
45 hsa-miR-96-5p FN1 1.42 0 2.78 0 MirTarget; TargetScan -0.28 0.00027 NA
46 hsa-let-7a-3p IGFBP3 0.1 0.42376 1.31 0 miRNATAP -0.24 0.00592 NA
47 hsa-miR-19a-3p IGFBP3 1.36 0 1.31 0 MirTarget; miRNATAP -0.11 0.0314 NA
48 hsa-miR-19b-3p IGFBP3 0.54 0.00062 1.31 0 MirTarget; miRNATAP -0.25 0.00012 NA
49 hsa-miR-34a-5p IGFBP3 -0.12 0.364 1.31 0 miRNATAP -0.36 1.0E-5 NA
50 hsa-miR-590-3p IGFBP3 0.22 0.09659 1.31 0 miRanda -0.18 0.02083 NA
51 hsa-miR-139-5p SPP1 -1.46 0 3.14 0 miRanda -0.98 0 NA
52 hsa-miR-335-5p SPP1 -1.17 0 3.14 0 miRNAWalker2 validate -0.3 0.00127 NA
53 hsa-miR-362-3p SPP1 -0.7 0 3.14 0 miRanda -0.5 1.0E-5 NA
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 EXTRACELLULAR SPACE 5 1376 8.662e-06 0.005058

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 ECM_receptor_interaction_hsa04512 3 82 1.317e-06 6.847e-05
2 Focal_adhesion_hsa04510 3 199 1.898e-05 0.0004936
3 PI3K_Akt_signaling_pathway_hsa04151 3 352 0.0001039 0.001802

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 CASC15 hsa-let-7a-3p;hsa-let-7g-5p;hsa-miR-193a-3p;hsa-miR-19b-3p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-32-5p;hsa-miR-33a-3p;hsa-miR-363-3p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-92a-3p 17 COL1A2 Sponge network 1.485 0 2.674 0 0.679
2 MAGI2-AS3 hsa-let-7a-3p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-25-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-30d-3p;hsa-miR-33a-3p;hsa-miR-342-3p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-92a-3p 13 COL1A2 Sponge network -0.939 4.0E-5 2.674 0 0.543
3 AC108142.1 hsa-let-7g-5p;hsa-miR-19b-3p;hsa-miR-25-3p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-33a-3p;hsa-miR-7-1-3p 11 COL1A2 Sponge network 2.31 0 2.674 0 0.444
4 LINC00702 hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-25-3p;hsa-miR-29b-3p;hsa-miR-30d-3p;hsa-miR-32-5p;hsa-miR-33a-3p;hsa-miR-342-3p;hsa-miR-363-3p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-92a-3p 12 COL1A2 Sponge network -0.573 0.0699 2.674 0 0.409
5 AC011738.4 hsa-let-7g-5p;hsa-miR-19b-3p;hsa-miR-25-3p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-32-5p;hsa-miR-33a-3p;hsa-miR-363-3p;hsa-miR-7-1-3p;hsa-miR-92a-3p 14 COL1A2 Sponge network 3.153 0 2.674 0 0.375
6 EMX2OS hsa-let-7a-3p;hsa-let-7d-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-25-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-30d-3p;hsa-miR-32-5p;hsa-miR-33a-3p;hsa-miR-342-3p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-92a-3p 14 COL1A2 Sponge network -1.459 1.0E-5 2.674 0 0.373
7 TBX5-AS1 hsa-let-7a-3p;hsa-miR-193a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-30d-3p;hsa-miR-363-3p;hsa-miR-7-1-3p;hsa-miR-92a-3p 10 COL1A2 Sponge network 0.014 0.98501 2.674 0 0.338
8 RP11-218E20.3 hsa-let-7g-5p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-32-5p;hsa-miR-363-3p 10 COL1A2 Sponge network 4.613 0 2.674 0 0.312
9 LINC00668 hsa-let-7g-5p;hsa-miR-26a-5p;hsa-miR-26b-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-363-3p 10 COL1A2 Sponge network 3.431 0 2.674 0 0.252

Quest ID: 677373df40161bab486fb56263a9eb92