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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-193b-3p ABI2 2.26 0 -0.65 0 miRNAWalker2 validate; MirTarget -0.11 0 NA
2 hsa-miR-193b-3p ADAMTSL3 2.26 0 -5.11 0 MirTarget -0.75 0 NA
3 hsa-miR-193b-3p ADARB1 2.26 0 -1.93 0 miRNAWalker2 validate; MirTarget -0.15 0.00224 NA
4 hsa-miR-193b-3p AKAP13 2.26 0 -1.15 0 miRNAWalker2 validate -0.19 0 NA
5 hsa-miR-193b-3p AKR1C2 2.26 0 -0.92 0.2246 miRNAWalker2 validate; miRTarBase -0.36 0.00246 NA
6 hsa-miR-193b-3p ALDH1A2 2.26 0 -1.89 0.0017 miRNAWalker2 validate -0.43 0 NA
7 hsa-miR-193b-3p ALDH7A1 2.26 0 -1.69 0.00179 miRNAWalker2 validate -0.25 0.00377 NA
8 hsa-miR-193b-3p APCDD1 2.26 0 -1.6 0 miRNAWalker2 validate -0.31 0 NA
9 hsa-miR-193b-3p APOLD1 2.26 0 -2.62 0 miRNAWalker2 validate -0.34 0 NA
10 hsa-miR-193b-3p ARHGEF12 2.26 0 -0.64 4.0E-5 MirTarget; miRNATAP -0.12 0 NA
11 hsa-miR-193b-3p ARL10 2.26 0 -1.12 0.00198 mirMAP -0.31 0 NA
12 hsa-miR-193b-3p ASH1L 2.26 0 -0.67 0.00016 miRNAWalker2 validate -0.12 2.0E-5 NA
13 hsa-miR-193b-3p ATF7IP2 2.26 0 -0.26 0.45537 MirTarget -0.2 0.00023 NA
14 hsa-miR-193b-3p ATOH8 2.26 0 -2.58 1.0E-5 miRNAWalker2 validate -0.81 0 NA
15 hsa-miR-193b-3p BCL2L2 2.26 0 -1.27 0 miRNATAP -0.11 2.0E-5 NA
16 hsa-miR-193b-3p BEND4 2.26 0 -1.97 7.0E-5 MirTarget -0.45 0 NA
17 hsa-miR-193b-3p BHLHE41 2.26 0 -0.07 0.8646 MirTarget -0.18 0.00394 NA
18 hsa-miR-193b-3p C1QTNF2 2.26 0 -2.64 0 miRNAWalker2 validate -0.27 0 NA
19 hsa-miR-193b-3p C5 2.26 0 -0.99 0.00071 miRNAWalker2 validate -0.13 0.00511 NA
20 hsa-miR-193b-3p CABLES1 2.26 0 -0.92 0.00535 mirMAP -0.14 0.00876 NA
21 hsa-miR-193b-3p CADM1 2.26 0 -1.19 0.01251 MirTarget -0.34 0 NA
22 hsa-miR-193b-3p CBX6 2.26 0 -1.54 0 mirMAP -0.25 0 NA
23 hsa-miR-193b-3p CBX7 2.26 0 -2.55 0 MirTarget; miRNATAP -0.45 0 NA
24 hsa-miR-193b-3p CEND1 2.26 0 -2.16 0 MirTarget -0.3 0 NA
25 hsa-miR-193b-3p CSRNP1 2.26 0 -2.73 0 MirTarget -0.24 0 NA
26 hsa-miR-193b-3p CTDSP2 2.26 0 -0.39 0.00969 miRNAWalker2 validate -0.1 2.0E-5 NA
27 hsa-miR-193b-3p CTNND2 2.26 0 -1.47 0.02616 MirTarget -0.47 1.0E-5 NA
28 hsa-miR-193b-3p DACT2 2.26 0 -2.95 1.0E-5 miRNAWalker2 validate -0.3 0.00333 NA
29 hsa-miR-193b-3p DDX43 2.26 0 -1.5 0.02086 MirTarget -0.21 0.0446 NA
30 hsa-miR-193b-3p EFHD1 2.26 0 -1.23 0.00418 miRNAWalker2 validate -0.2 0.00371 NA
31 hsa-miR-193b-3p EIF4B 2.26 0 -0.84 0 miRNAWalker2 validate -0.13 0 NA
32 hsa-miR-193b-3p EP300 2.26 0 -0.26 0.13065 miRNAWalker2 validate -0.11 8.0E-5 NA
33 hsa-miR-193b-3p EPDR1 2.26 0 -1.64 0.00035 miRNAWalker2 validate -0.28 0.00011 NA
34 hsa-miR-193b-3p EPHX1 2.26 0 -1.2 1.0E-5 miRNAWalker2 validate -0.13 0.0024 NA
35 hsa-miR-193b-3p ERBB4 2.26 0 -0.99 0.1413 MirTarget; miRNATAP -0.49 0 NA
36 hsa-miR-193b-3p ESR1 2.26 0 -2.87 0 miRNAWalker2 validate; miRTarBase -0.25 0.00078 NA
37 hsa-miR-193b-3p ETS1 2.26 0 -0.7 0.00228 miRNAWalker2 validate; miRTarBase -0.12 0.00129 20655737 CCND1 and ETS1 were revealed to be regulated by miR-193b directly
38 hsa-miR-193b-3p ETV1 2.26 0 -0.69 0.03823 MirTarget; miRNATAP -0.17 0.00098 NA
39 hsa-miR-193b-3p FAM84A 2.26 0 -0.46 0.38875 MirTarget -0.37 1.0E-5 NA
40 hsa-miR-193b-3p FAT4 2.26 0 -2.57 0 MirTarget; miRNATAP -0.5 0 NA
41 hsa-miR-193b-3p FLI1 2.26 0 -1.11 7.0E-5 MirTarget -0.14 0.00101 NA
42 hsa-miR-193b-3p FLNA 2.26 0 -2.63 0 miRNAWalker2 validate -0.16 0.00803 NA
43 hsa-miR-193b-3p GNAO1 2.26 0 -3.6 0 MirTarget -0.41 0 NA
44 hsa-miR-193b-3p GRIK3 2.26 0 -4.42 0 mirMAP -0.71 0 NA
45 hsa-miR-193b-3p HERC1 2.26 0 -1 0 miRNAWalker2 validate -0.16 0 NA
46 hsa-miR-193b-3p HERC2 2.26 0 -0.33 0.01553 miRNAWalker2 validate -0.11 0 NA
47 hsa-miR-193b-3p HHAT 2.26 0 -0.16 0.48879 miRNAWalker2 validate; MirTarget -0.17 0 NA
48 hsa-miR-193b-3p IGFBP5 2.26 0 -2.81 0 miRNATAP -0.35 1.0E-5 25983620 Experimental and bioinformatics studies have shown that IGFBP5 is targeted by miR-140-5p and miR-193b although this has not yet been proven in clinical samples; The aim of this study was to evaluate the expression of miR-140-5p and miR-193b in breast cancer and adjacent normal tissue and assess its correlation with IGFBP5 and the clinicopathological characteristics of the tumors; IGFBP5 protein expression was analyzed immunohistochemically and IGFBP5 miR-140 and miR-193b mRNA expression levels were analyzed with real-time RT-PCR; These findings suggest that miR-140-5p but not miR-193b could be an important determinant of IGFBP5 expression and clinical phenotype in breast cancer patients
49 hsa-miR-193b-3p IGSF9B 2.26 0 -3.7 0 mirMAP -0.72 0 NA
50 hsa-miR-193b-3p IL6R 2.26 0 -1.87 0 mirMAP -0.15 0.01567 NA
51 hsa-miR-193b-3p JMY 2.26 0 -0.98 0 MirTarget -0.2 0 NA
52 hsa-miR-193b-3p KANK2 2.26 0 -2.39 0 miRNAWalker2 validate -0.3 0 NA
53 hsa-miR-193b-3p KBTBD11 2.26 0 -2.19 0 miRNAWalker2 validate -0.46 0 NA
54 hsa-miR-193b-3p KCNH8 2.26 0 -0.76 0.22547 miRNATAP -0.4 4.0E-5 NA
55 hsa-miR-193b-3p KCNQ5 2.26 0 -3.67 0 MirTarget; miRNATAP -0.33 0.00147 NA
56 hsa-miR-193b-3p KCTD15 2.26 0 -1.07 0.00367 mirMAP -0.15 0.00792 NA
57 hsa-miR-193b-3p KIAA0430 2.26 0 -0.75 0 MirTarget; miRNATAP -0.16 0 NA
58 hsa-miR-193b-3p KIAA0513 2.26 0 -1.87 0 mirMAP -0.38 0 NA
59 hsa-miR-193b-3p KIF1A 2.26 0 -0.61 0.45499 mirMAP -0.28 0.03145 NA
60 hsa-miR-193b-3p KIT 2.26 0 -2.52 0 MirTarget; miRNATAP -0.69 0 NA
61 hsa-miR-193b-3p KLHL15 2.26 0 -1.08 0 miRNATAP -0.12 0 NA
62 hsa-miR-193b-3p LCOR 2.26 0 -0.36 0.27591 miRNAWalker2 validate -0.17 0.00112 NA
63 hsa-miR-193b-3p LMCD1 2.26 0 -2.02 0 miRNAWalker2 validate -0.24 4.0E-5 NA
64 hsa-miR-193b-3p LOXL1 2.26 0 -0.2 0.57215 miRNAWalker2 validate -0.21 0.00023 NA
65 hsa-miR-193b-3p LPP 2.26 0 -2.04 0 miRNATAP -0.33 0 NA
66 hsa-miR-193b-3p MAP3K3 2.26 0 -0.87 0 miRNAWalker2 validate; miRNATAP -0.12 0 NA
67 hsa-miR-193b-3p MAT2A 2.26 0 -1.04 0 miRNAWalker2 validate -0.1 0 NA
68 hsa-miR-193b-3p MBNL3 2.26 0 -1.4 8.0E-5 miRNATAP -0.25 1.0E-5 NA
69 hsa-miR-193b-3p MEGF8 2.26 0 -0.61 0.00013 miRNAWalker2 validate -0.18 0 NA
70 hsa-miR-193b-3p MTHFR 2.26 0 -0.84 0 mirMAP -0.12 0 NA
71 hsa-miR-193b-3p MTR 2.26 0 -0.56 4.0E-5 miRNAWalker2 validate -0.11 0 NA
72 hsa-miR-193b-3p MXRA7 2.26 0 -1.86 0 miRNAWalker2 validate -0.14 0.0002 NA
73 hsa-miR-193b-3p MYLK 2.26 0 -3.92 0 miRNAWalker2 validate -0.39 0 NA
74 hsa-miR-193b-3p MYO18B 2.26 0 -2.8 1.0E-5 MirTarget -0.39 0.00011 NA
75 hsa-miR-193b-3p NAV3 2.26 0 -3.22 0 MirTarget -0.3 0.00012 NA
76 hsa-miR-193b-3p NCOA2 2.26 0 -0.91 0.02122 miRNAWalker2 validate -0.15 0.01946 NA
77 hsa-miR-193b-3p NFIA 2.26 0 -2.1 0 miRNAWalker2 validate -0.19 1.0E-5 NA
78 hsa-miR-193b-3p NOVA1 2.26 0 -4.22 0 miRNATAP -0.81 0 NA
79 hsa-miR-193b-3p NPAS4 2.26 0 -5.02 0 miRNATAP -0.58 0 NA
80 hsa-miR-193b-3p NT5DC3 2.26 0 -1.57 0 miRNAWalker2 validate -0.14 0.00051 NA
81 hsa-miR-193b-3p OLFML3 2.26 0 -2.78 0 MirTarget -0.29 4.0E-5 NA
82 hsa-miR-193b-3p PEG10 2.26 0 -1.94 0.00571 miRNAWalker2 validate -0.37 0.00073 NA
83 hsa-miR-193b-3p PER3 2.26 0 -1.84 0 MirTarget -0.19 0.00011 NA
84 hsa-miR-193b-3p PIKFYVE 2.26 0 -0.44 0.00371 MirTarget -0.12 0 NA
85 hsa-miR-193b-3p PIP5K1C 2.26 0 -0.76 0 miRNAWalker2 validate -0.12 0 NA
86 hsa-miR-193b-3p PLCH1 2.26 0 0.64 0.22214 miRNATAP -0.21 0.01202 NA
87 hsa-miR-193b-3p PLXNC1 2.26 0 -0.53 0.2847 miRNAWalker2 validate; miRNATAP -0.19 0.01799 NA
88 hsa-miR-193b-3p PM20D2 2.26 0 -0.65 0.00796 miRNAWalker2 validate -0.15 7.0E-5 NA
89 hsa-miR-193b-3p PPARGC1B 2.26 0 -1.48 0 miRNAWalker2 validate; mirMAP -0.22 0 NA
90 hsa-miR-193b-3p PRDM16 2.26 0 -2.56 0 mirMAP -0.17 0.04038 NA
91 hsa-miR-193b-3p PRICKLE4 2.26 0 0.15 0.68931 miRNAWalker2 validate -0.16 0.00643 NA
92 hsa-miR-193b-3p PRKCA 2.26 0 -1.04 0.00033 miRNAWalker2 validate -0.18 6.0E-5 NA
93 hsa-miR-193b-3p PTGS1 2.26 0 -4.36 0 miRNAWalker2 validate -0.31 0.00047 NA
94 hsa-miR-193b-3p PTPRG 2.26 0 -0.66 0.03988 miRNAWalker2 validate -0.21 2.0E-5 NA
95 hsa-miR-193b-3p RASSF3 2.26 0 -1.96 0 miRNAWalker2 validate -0.2 0.00076 NA
96 hsa-miR-193b-3p RASSF5 2.26 0 -0.46 0.05708 miRNAWalker2 validate -0.11 0.0046 NA
97 hsa-miR-193b-3p RBM20 2.26 0 -2.46 0 MirTarget -0.61 0 NA
98 hsa-miR-193b-3p RGMA 2.26 0 -2.73 0 MirTarget -0.35 0.00015 NA
99 hsa-miR-193b-3p RHBDL3 2.26 0 -2.21 2.0E-5 mirMAP -0.39 0 NA
100 hsa-miR-193b-3p RORA 2.26 0 -1.82 0 miRNATAP -0.17 0.00044 NA
101 hsa-miR-193b-3p RPS6KA2 2.26 0 -1.9 0 mirMAP -0.31 0 NA
102 hsa-miR-193b-3p RUNX1T1 2.26 0 -3.29 0 miRNATAP -0.52 0 NA
103 hsa-miR-193b-3p SDC3 2.26 0 -1.17 0 mirMAP -0.14 4.0E-5 NA
104 hsa-miR-193b-3p SDK2 2.26 0 -1.52 0.00193 mirMAP -0.18 0.01828 NA
105 hsa-miR-193b-3p SLCO2A1 2.26 0 -1.01 0.00213 miRNATAP -0.2 0.00012 NA
106 hsa-miR-193b-3p SNRK 2.26 0 -1.03 0 miRNAWalker2 validate -0.16 0 NA
107 hsa-miR-193b-3p SNX18 2.26 0 -0.68 1.0E-5 miRNAWalker2 validate -0.11 1.0E-5 NA
108 hsa-miR-193b-3p SPATA13 2.26 0 -0.77 0.04293 MirTarget -0.24 6.0E-5 NA
109 hsa-miR-193b-3p TACC1 2.26 0 -1.71 0 miRNAWalker2 validate -0.29 0 NA
110 hsa-miR-193b-3p TAPT1 2.26 0 -0.7 0 MirTarget -0.15 0 NA
111 hsa-miR-193b-3p TBC1D1 2.26 0 -0.84 5.0E-5 miRNAWalker2 validate -0.12 0.00037 NA
112 hsa-miR-193b-3p TCF4 2.26 0 -1.61 0 MirTarget; miRNATAP -0.26 0 NA
113 hsa-miR-193b-3p TGFBR3 2.26 0 -2.59 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.54 0 NA
114 hsa-miR-193b-3p TLE4 2.26 0 -1.39 0 miRNAWalker2 validate -0.25 0 NA
115 hsa-miR-193b-3p TM7SF2 2.26 0 0.89 0.01976 miRNAWalker2 validate -0.13 0.02896 NA
116 hsa-miR-193b-3p TMEM204 2.26 0 -0.67 0.00683 miRNAWalker2 validate -0.21 0 NA
117 hsa-miR-193b-3p TMTC1 2.26 0 -2.58 0 miRNAWalker2 validate -0.49 0 NA
118 hsa-miR-193b-3p TRAK2 2.26 0 -1 0 miRNAWalker2 validate -0.15 0 NA
119 hsa-miR-193b-3p TSPAN18 2.26 0 -2.63 0 mirMAP -0.4 0 NA
120 hsa-miR-193b-3p TTBK1 2.26 0 0.59 0.10857 mirMAP -0.14 0.01609 NA
121 hsa-miR-193b-3p TUBGCP6 2.26 0 0.02 0.88774 miRNAWalker2 validate -0.11 2.0E-5 NA
122 hsa-miR-193b-3p UBR1 2.26 0 -0.87 0 miRNAWalker2 validate -0.12 0 NA
123 hsa-miR-193b-3p UNC5B 2.26 0 0.06 0.82209 miRNAWalker2 validate -0.11 0.00733 NA
124 hsa-miR-193b-3p VASH1 2.26 0 -0.34 0.11673 MirTarget -0.17 0 NA
125 hsa-miR-193b-3p ZMAT3 2.26 0 -0.83 0.00034 MirTarget -0.19 0 NA
126 hsa-miR-193b-3p ZNF385B 2.26 0 -2.94 0 MirTarget -0.22 0.02507 NA
127 hsa-miR-193b-3p ZNF814 2.26 0 0.43 0.05095 miRNAWalker2 validate -0.1 0.00357 NA
NumGOOverlapSizeP ValueAdj. P Value
1 CARDIOVASCULAR SYSTEM DEVELOPMENT 19 788 5.671e-07 0.001319
2 CIRCULATORY SYSTEM DEVELOPMENT 19 788 5.671e-07 0.001319
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSCRIPTION FACTOR BINDING 15 524 1.214e-06 0.001128
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Regulation_of_actin_cytoskeleton_hsa04810 6 208 0.002145 0.1116
2 MAPK_signaling_pathway_hsa04010 6 295 0.01145 0.2978
3 Phosphatidylinositol_signaling_system_hsa04070 3 99 0.02522 0.3365
4 HIF_1_signaling_pathway_hsa04066 3 100 0.02589 0.3365
5 Focal_adhesion_hsa04510 4 199 0.03821 0.3497
6 Rap1_signaling_pathway_hsa04015 4 206 0.04248 0.3497
7 Ras_signaling_pathway_hsa04014 4 232 0.06064 0.3497
8 Phospholipase_D_signaling_pathway_hsa04072 3 146 0.06614 0.3497
9 Wnt_signaling_pathway_hsa04310 3 146 0.06614 0.3497
10 mTOR_signaling_pathway_hsa04150 3 151 0.07161 0.3497
11 PI3K_Akt_signaling_pathway_hsa04151 5 352 0.07399 0.3497
12 ErbB_signaling_pathway_hsa04012 2 85 0.1017 0.4387
13 Calcium_signaling_pathway_hsa04020 3 182 0.1097 0.4387
14 Cell_adhesion_molecules_.CAMs._hsa04514 2 145 0.2349 0.794
15 Cellular_senescence_hsa04218 2 160 0.2702 0.794
16 Jak_STAT_signaling_pathway_hsa04630 2 162 0.2749 0.794
17 Cytokine_cytokine_receptor_interaction_hsa04060 2 270 0.5134 1

Quest ID: 67b7c3c449bcef80c991f01d5e660399