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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-143-3p ABHD14A -0.04 0.98732 -0.02 0.97145 MirTarget -0.12 0.03969 NA
2 hsa-miR-143-3p ABLIM1 -0.04 0.98732 -0.18 0.86881 mirMAP -0.14 0.00716 NA
3 hsa-miR-125b-5p ACPP 0.01 0.99458 -0.43 0.34039 MirTarget -0.24 0.017 NA
4 hsa-miR-1275 ACSS3 -0.09 0.78713 0.28 0.50072 MirTarget -0.24 0.00666 NA
5 hsa-miR-1275 ADAM11 -0.09 0.78713 0.11 0.80369 MirTarget -0.25 0.00022 NA
6 hsa-miR-222-3p ADAM11 0.07 0.93415 0.11 0.80369 miRNATAP -0.33 0.00543 NA
7 hsa-miR-320c ADAM12 -0.63 0.02294 0.33 0.62453 mirMAP -0.22 0.03705 NA
8 hsa-miR-320c ADAM19 -0.63 0.02294 0.14 0.86039 mirMAP -0.21 0.00033 NA
9 hsa-miR-222-3p ADAM22 0.07 0.93415 -0.44 0.16218 MirTarget; miRNATAP -0.4 0.0004 NA
10 hsa-miR-320c ADAMTS14 -0.63 0.02294 0.14 0.7614 miRanda -0.19 0.00042 NA
11 hsa-miR-10a-5p ADAMTS2 -0.1 0.96336 0.15 0.81881 MirTarget -0.59 0 NA
12 hsa-miR-320c ADAMTS3 -0.63 0.02294 -0.15 0.57772 mirMAP -0.15 0.01997 NA
13 hsa-miR-222-3p ADAMTS6 0.07 0.93415 0.02 0.94873 MirTarget -0.33 0.00033 NA
14 hsa-miR-320c ADAMTSL1 -0.63 0.02294 -0.22 0.5533 miRanda; mirMAP -0.21 0.00993 NA
15 hsa-miR-1275 ADAP2 -0.09 0.78713 0.28 0.47595 MirTarget -0.18 0 NA
16 hsa-miR-1275 ADARB1 -0.09 0.78713 -0.03 0.95215 MirTarget -0.12 0.00013 NA
17 hsa-miR-10a-5p ADCY1 -0.1 0.96336 0.38 0.25371 mirMAP -0.44 1.0E-5 NA
18 hsa-miR-1275 ADCY2 -0.09 0.78713 0.09 0.80312 MirTarget -0.2 0.00728 NA
19 hsa-miR-320c ADCY5 -0.63 0.02294 -0.55 0.2334 mirMAP -0.26 0.0356 NA
20 hsa-miR-10a-5p ADCY9 -0.1 0.96336 -0.21 0.75553 miRNAWalker2 validate -0.12 0.00432 NA
21 hsa-miR-320c ADCYAP1 -0.63 0.02294 0.13 0.79662 PITA; miRanda; miRNATAP -0.36 0.00736 NA
22 hsa-miR-143-3p ADD3 -0.04 0.98732 -0.06 0.9558 MirTarget; miRNATAP -0.21 1.0E-5 NA
23 hsa-miR-125b-5p ADM 0.01 0.99458 0.22 0.72879 miRNAWalker2 validate -0.19 0.00249 NA
24 hsa-miR-320c ADRA1D -0.63 0.02294 0.05 0.91238 miRanda -0.3 0.00022 NA
25 hsa-miR-1275 ADRB2 -0.09 0.78713 -0.01 0.98489 MirTarget -0.25 0.00023 NA
26 hsa-miR-1275 AFF3 -0.09 0.78713 -0.5 0.15768 MirTarget -0.22 0.00414 NA
27 hsa-miR-10a-5p AGAP2 -0.1 0.96336 -0.04 0.9189 mirMAP -0.24 0.03151 NA
28 hsa-miR-1275 AGAP2 -0.09 0.78713 -0.04 0.9189 MirTarget; miRNATAP -0.21 0.00369 NA
29 hsa-miR-1275 AKT3 -0.09 0.78713 0.06 0.90908 PITA -0.27 0 NA
30 hsa-miR-320c AKT3 -0.63 0.02294 0.06 0.90908 PITA; miRanda; miRNATAP -0.17 0.01525 NA
31 hsa-miR-10a-5p ALDH1A2 -0.1 0.96336 0.56 0.37561 miRNAWalker2 validate -0.49 0.01459 NA
32 hsa-miR-100-5p ALG3 -0.08 0.95816 0.07 0.93782 miRNAWalker2 validate -0.12 0 NA
33 hsa-miR-1275 AMOTL1 -0.09 0.78713 -0.11 0.85689 miRNATAP -0.26 2.0E-5 NA
34 hsa-miR-10a-5p AMPD1 -0.1 0.96336 0.03 0.96951 miRNAWalker2 validate -0.41 0.00389 NA
35 hsa-miR-320c AMPH -0.63 0.02294 0.08 0.81124 miRanda -0.21 0.01556 NA
36 hsa-miR-222-3p ANGPTL2 0.07 0.93415 -0.07 0.92845 MirTarget; miRNATAP -0.59 0 NA
37 hsa-miR-10a-5p ANK2 -0.1 0.96336 0.04 0.93166 miRNATAP -0.64 0 NA
38 hsa-miR-1275 ANK2 -0.09 0.78713 0.04 0.93166 MirTarget -0.31 4.0E-5 NA
39 hsa-miR-222-3p ANKRD12 0.07 0.93415 -0.2 0.77041 MirTarget -0.11 0.00921 NA
40 hsa-miR-10a-5p AOC3 -0.1 0.96336 -0.07 0.92679 mirMAP -0.7 0 NA
41 hsa-miR-100-5p APEX1 -0.08 0.95816 0.02 0.98521 miRNAWalker2 validate -0.1 0.00037 NA
42 hsa-miR-1275 APLNR -0.09 0.78713 0.01 0.99326 MirTarget -0.23 1.0E-5 NA
43 hsa-miR-143-3p APPL2 -0.04 0.98732 -0.14 0.86677 MirTarget -0.1 0.00491 NA
44 hsa-miR-222-3p AQP3 0.07 0.93415 -0.02 0.97583 MirTarget -0.49 0.00044 NA
45 hsa-miR-1275 AQP9 -0.09 0.78713 0.18 0.73115 MirTarget -0.51 0 NA
46 hsa-miR-143-3p ARHGAP26 -0.04 0.98732 -0.15 0.86008 MirTarget -0.14 0.00199 NA
47 hsa-miR-128-3p ARHGEF37 -0.09 0.92304 -0.02 0.96611 MirTarget -0.41 0 NA
48 hsa-miR-192-5p ARHGEF37 0.07 0.97377 -0.02 0.96611 mirMAP -0.16 0.00274 NA
49 hsa-miR-590-5p ARHGEF37 -0.06 0.89349 -0.02 0.96611 mirMAP -0.17 0.00372 NA
50 hsa-miR-1275 ARL10 -0.09 0.78713 -0.24 0.42733 mirMAP -0.16 0.00834 NA
51 hsa-miR-320c ASB5 -0.63 0.02294 -0.2 0.80838 PITA; miRanda -0.27 0.03057 NA
52 hsa-miR-106a-5p ASPA -0.22 0.67134 -0.3 0.57461 mirMAP -0.61 0 NA
53 hsa-miR-106b-5p ASPA 0.01 0.99606 -0.3 0.57461 mirMAP -0.8 0 NA
54 hsa-miR-1304-5p ASPA -0.57 0.04499 -0.3 0.57461 mirMAP -0.3 0.00077 NA
55 hsa-miR-130b-3p ASPA 0.09 0.88082 -0.3 0.57461 mirMAP -0.75 0 NA
56 hsa-miR-135b-5p ASPA 0.33 0.68286 -0.3 0.57461 mirMAP -0.47 0 NA
57 hsa-miR-15b-3p ASPA -0.19 0.78005 -0.3 0.57461 mirMAP -0.71 0 NA
58 hsa-miR-17-5p ASPA 0.02 0.9896 -0.3 0.57461 mirMAP -0.8 0 NA
59 hsa-miR-181a-5p ASPA 0.08 0.95532 -0.3 0.57461 mirMAP -0.32 0.02996 NA
60 hsa-miR-181b-5p ASPA 0.08 0.94249 -0.3 0.57461 mirMAP -0.37 0.00945 NA
61 hsa-miR-20a-3p ASPA 0 0.99335 -0.3 0.57461 mirMAP -0.6 0 NA
62 hsa-miR-20a-5p ASPA 0.03 0.97939 -0.3 0.57461 mirMAP -0.71 0 NA
63 hsa-miR-221-3p ASPA 0.06 0.95442 -0.3 0.57461 MirTarget -0.61 4.0E-5 NA
64 hsa-miR-222-3p ASPA 0.07 0.93415 -0.3 0.57461 MirTarget -0.71 0 NA
65 hsa-miR-224-3p ASPA 0.03 0.90323 -0.3 0.57461 mirMAP -0.28 0.0031 NA
66 hsa-miR-23a-3p ASPA -0.02 0.99063 -0.3 0.57461 mirMAP -1.36 0 NA
67 hsa-miR-29b-1-5p ASPA -0.12 0.75664 -0.3 0.57461 mirMAP -0.56 0 NA
68 hsa-miR-301a-3p ASPA -0.08 0.81159 -0.3 0.57461 mirMAP -0.51 0 NA
69 hsa-miR-320a ASPA -0.11 0.93187 -0.3 0.57461 miRanda -0.34 0.01887 NA
70 hsa-miR-33a-5p ASPA -0.13 0.85242 -0.3 0.57461 mirMAP -0.43 0 NA
71 hsa-miR-33b-5p ASPA 0.36 0.30965 -0.3 0.57461 mirMAP -0.33 0 NA
72 hsa-miR-374b-3p ASPA -0.08 0.72231 -0.3 0.57461 mirMAP -0.41 0.00186 NA
73 hsa-miR-450b-5p ASPA 0.15 0.72052 -0.3 0.57461 mirMAP -0.28 0.02534 NA
74 hsa-miR-452-5p ASPA -0.04 0.96894 -0.3 0.57461 mirMAP -0.49 2.0E-5 NA
75 hsa-miR-454-3p ASPA -0.16 0.6417 -0.3 0.57461 mirMAP -0.86 0 NA
76 hsa-miR-590-3p ASPA 0.08 0.81071 -0.3 0.57461 miRanda; mirMAP -0.46 0 NA
77 hsa-miR-93-5p ASPA -0.09 0.95565 -0.3 0.57461 mirMAP -0.8 0 NA
78 hsa-miR-320c ASTN1 -0.63 0.02294 0.05 0.94222 mirMAP -0.29 0.0081 NA
79 hsa-miR-222-3p ATF2 0.07 0.93415 -0.24 0.68896 MirTarget -0.15 3.0E-5 NA
80 hsa-miR-143-3p ATG10 -0.04 0.98732 0.06 0.85705 MirTarget -0.12 0.00941 NA
81 hsa-miR-10a-5p ATP1A2 -0.1 0.96336 -0.91 0.10704 miRNAWalker2 validate -0.83 1.0E-5 NA
82 hsa-miR-1275 ATP1B2 -0.09 0.78713 -0.1 0.73974 MirTarget; miRNATAP -0.15 0.01794 NA
83 hsa-miR-100-5p ATP1B3 -0.08 0.95816 0.16 0.88053 miRNAWalker2 validate -0.11 0.00016 NA
84 hsa-miR-100-5p ATP5A1 -0.08 0.95816 -0.03 0.97877 miRNAWalker2 validate -0.16 0 NA
85 hsa-miR-125b-5p ATP5B 0.01 0.99458 0.08 0.95229 miRNAWalker2 validate -0.17 0 NA
86 hsa-miR-100-5p ATP5L -0.08 0.95816 0.15 0.88435 miRNAWalker2 validate -0.11 4.0E-5 NA
87 hsa-miR-222-3p ATXN1 0.07 0.93415 -0.02 0.9752 miRNATAP -0.24 0 NA
88 hsa-miR-125b-5p AURKB 0.01 0.99458 0.03 0.96116 miRNAWalker2 validate -0.16 4.0E-5 NA
89 hsa-miR-222-3p AUTS2 0.07 0.93415 -0.33 0.70429 miRNAWalker2 validate -0.36 3.0E-5 NA
90 hsa-miR-125b-5p B3GNT3 0.01 0.99458 0.17 0.86636 MirTarget -0.12 0.00103 NA
91 hsa-miR-10a-5p B3GNT7 -0.1 0.96336 -0.13 0.84911 mirMAP -0.34 0.01507 NA
92 hsa-miR-320c B4GALNT1 -0.63 0.02294 0.22 0.35887 miRanda -0.16 0.0131 NA
93 hsa-miR-10a-5p BACH2 -0.1 0.96336 -0.35 0.26727 MirTarget; miRNATAP -0.5 0 NA
94 hsa-miR-1275 BACH2 -0.09 0.78713 -0.35 0.26727 MirTarget -0.26 8.0E-5 NA
95 hsa-miR-125b-5p BAG4 0.01 0.99458 -0.21 0.6077 MirTarget; miRNATAP -0.13 0.00056 NA
96 hsa-miR-125b-5p BAK1 0.01 0.99458 0.22 0.78301 miRNAWalker2 validate; miRTarBase; miRNATAP -0.2 0 24643683; 27386402; 21823019; 18056640; 23928699; 20460378 miR 125b inhibitor enhance the chemosensitivity of glioblastoma stem cells to temozolomide by targeting Bak1; Moreover we demonstrated that the pro-apoptotic Bcl-2 antagonist killer 1 Bak1 was a direct target of miR-125b; Taken together; our data strongly support an important role for miR-125b on conferring TMZ resistance through targeting Bak1 expression;We subsequently evaluated the effect of miR-125b-1 reactivation on the expression and protein levels of BAK1 a target of miR-125b;An in vitro cytotoxicity assay and apoptosis assay using CCK-8 assay and flow cytometry were carried out to detect the effect of miR-125b and Bak1 on cisplatin resistance of cells; Real-time PCR Western blotting and luciferase reporter assay were used to detect whether Bak1 is a target of miR-125b; Moreover Bak1 was a direct target of miR-125b and down-regulation of Bak1 suppressed cisplatin-induced apoptosis and led to an increased resistance to cisplatin; Our study indicates that miR-125b has a significantly promoting effect on chemoresistance of C13* cells and up-regulation of miR-125b expression contributes to cisplatin resistance through suppression of Bak1 expression;In addition transfection of synthetic miR-125b stimulated androgen-independent growth of CaP cells and down-regulated the expression of Bak1;In contrast miR-125b sponge impaired the anti-apoptotic effect of OCT4 along with the upregulated expression of BAK1; Significantly Luciferase assay showed that the activity of the wild-type BAK1 3'-untranslated region reporter was suppressed and this suppression was diminished when the miR-125b response element was mutated or deleted; In addition we observed negative correlation between levels of BAK1 and OCT4 and positive between OCT4 and miR-125b in primary cervical cancers; These findings suggest an undescribed regulatory pathway in cervical cancer by which OCT4 directly induces expression of miR-125b which inhibits its direct target BAK1 leading to suppression of cervical cancer cell apoptosis;Moreover we demonstrated that the pro-apoptotic Bcl-2 antagonist killer 1 Bak1 is a direct target of miR-125b; Restoring Bak1 expression by either miR-125b inhibitor or re-expression of Bak1 in miR-125b-overexpressing cells recovered Taxol sensitivity overcoming miR-125-mediated Taxol resistance; Taken together our data strongly support a central role for miR-125b in conferring Taxol resistance through the suppression of Bak1 expression
97 hsa-miR-320c BASP1 -0.63 0.02294 0.06 0.91132 PITA; miRanda -0.15 0.03318 NA
98 hsa-miR-143-3p BBC3 -0.04 0.98732 0.01 0.98681 miRNATAP -0.12 0.03684 NA
99 hsa-miR-1275 BCAT1 -0.09 0.78713 0.28 0.58837 MirTarget -0.27 0 NA
100 hsa-miR-320c BCAT1 -0.63 0.02294 0.28 0.58837 MirTarget; miRanda; miRNATAP -0.16 0.03425 NA
101 hsa-miR-320c BCHE -0.63 0.02294 0.37 0.44318 miRanda -0.35 0.00347 NA
102 hsa-miR-100-5p BCL10 -0.08 0.95816 -0.04 0.95563 miRNAWalker2 validate -0.16 0 NA
103 hsa-miR-153-3p BCL2 -0.1 0.78424 -0.44 0.34621 miRNAWalker2 validate; miRTarBase -0.12 0.0323 19676043; 21213215 Bioinformatics analysis revealed that anti-apoptosis family member B-cell lymphoma 2 Bcl-2 and myeloid cell leukemia sequence 1 Mcl-1 are potential targets of miR-153; Indeed Western blot analysis indicated that miR-153 downregulated both Bcl-2 and Mcl-1 at the protein levels; By luciferase reporter assays we further showed that miR-153 inhibited Bcl-2 and Mcl-1 expressions by directly targeting the 3'UTR regions of their respective mRNAs;Previously we established that microRNA-153 miR-153 induces apoptosis by downregulating B-cell lymphoma 2 Bcl-2 and myeloid cell leukemia sequence 1 Mcl-1 protein expression levels in glioblastoma cell line DBTRG-05MG
104 hsa-miR-15a-5p BCL2 0.11 0.90237 -0.44 0.34621 miRNAWalker2 validate; miRTarBase -0.22 0.02911 25623762; 25594541; 26915294; 18931683; 22335947 miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05
105 hsa-miR-16-5p BCL2 0.17 0.88456 -0.44 0.34621 miRNAWalker2 validate; miRTarBase -0.23 0.01553 25623762; 21336967; 24447552; 18449891; 25435430; 24598659; 18931683; 22966344 miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene
106 hsa-miR-17-5p BCL2 0.02 0.9896 -0.44 0.34621 miRNAWalker2 validate; miRTarBase -0.31 2.0E-5 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2
107 hsa-miR-192-5p BCL2 0.07 0.97377 -0.44 0.34621 miRNAWalker2 validate -0.23 0.00056 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192
108 hsa-miR-196b-5p BCL2 -0.41 0.78643 -0.44 0.34621 miRNAWalker2 validate -0.13 0.00926 NA
109 hsa-miR-20a-3p BCL2 0 0.99335 -0.44 0.34621 mirMAP -0.19 0.00115 NA
110 hsa-miR-20a-5p BCL2 0.03 0.97939 -0.44 0.34621 miRNAWalker2 validate; miRTarBase -0.25 0.00046 NA
111 hsa-miR-224-3p BCL2 0.03 0.90323 -0.44 0.34621 mirMAP -0.18 0.00775 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01
112 hsa-miR-224-5p BCL2 0.01 0.99347 -0.44 0.34621 mirMAP -0.3 0 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01
113 hsa-miR-24-2-5p BCL2 0.08 0.89571 -0.44 0.34621 miRNAWalker2 validate; miRTarBase -0.41 0.00012 NA
114 hsa-miR-29a-3p BCL2 0.04 0.98081 -0.44 0.34621 miRNAWalker2 validate; miRTarBase -0.34 0.00194 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29
115 hsa-miR-29a-5p BCL2 0.08 0.82991 -0.44 0.34621 mirMAP -0.34 1.0E-5 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29
116 hsa-miR-29b-3p BCL2 0 0.99797 -0.44 0.34621 miRNAWalker2 validate; miRTarBase -0.27 0.00119 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29
117 hsa-miR-335-3p BCL2 -0.17 0.87115 -0.44 0.34621 mirMAP -0.25 0.00118 NA
118 hsa-miR-33a-5p BCL2 -0.13 0.85242 -0.44 0.34621 mirMAP -0.13 0.00456 NA
119 hsa-miR-374b-5p BCL2 -0.27 0.75538 -0.44 0.34621 mirMAP -0.29 0.0137 NA
120 hsa-miR-450b-5p BCL2 0.15 0.72052 -0.44 0.34621 mirMAP -0.24 0.00586 NA
121 hsa-miR-452-5p BCL2 -0.04 0.96894 -0.44 0.34621 mirMAP -0.28 0.00061 NA
122 hsa-miR-590-5p BCL2 -0.06 0.89349 -0.44 0.34621 miRanda -0.18 0.01554 NA
123 hsa-miR-7-5p BCL2 0.23 0.64973 -0.44 0.34621 miRNAWalker2 validate; miRTarBase; mirMAP -0.2 0.00018 26464649; 25862909; 21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions
124 hsa-miR-125b-5p BCL3 0.01 0.99458 0.02 0.97668 miRNAWalker2 validate; miRTarBase -0.11 0.0014 20658525; 25944662 MiR 125b targets BCL3 and suppresses ovarian cancer proliferation; This inhibitory effect on OC cell growth was mediated by miR-125b inhibition of the translation of an mRNA encoding a proto-oncogene BCL3;In ovarian cancer miR-125b has been shown to be downregulated and acts as a tumor suppressor by targeting proto-oncogene BCL3; Thus our results suggest that PPARγ can induce growth suppression of ovarian cancer by upregulating miR-125b which inhibition of proto-oncogene BCL3
125 hsa-miR-10a-5p BCL6 -0.1 0.96336 -0.02 0.97924 MirTarget; miRNATAP -0.2 0.00024 26590574 Luciferase reporter assay was used to analyze the regulation of miR-10a on the expression of BCL6; In addition miR-10a was found to target BCL6 and regulated its expression in transcription and translation levels; Correlation analysis revealed that the level of miR-10a in serum of AML patients was negatively correlated with BCL6 in BM-MSC
126 hsa-miR-125b-5p BDH1 0.01 0.99458 0.03 0.975 MirTarget -0.13 0.0019 NA
127 hsa-miR-1275 BEGAIN -0.09 0.78713 -0.24 0.41919 MirTarget -0.19 0.00174 NA
128 hsa-miR-222-3p BEND4 0.07 0.93415 0.03 0.96594 mirMAP; miRNATAP -0.6 3.0E-5 NA
129 hsa-miR-320c BEST1 -0.63 0.02294 0.11 0.57779 mirMAP -0.13 0.0087 NA
130 hsa-miR-320c BEX1 -0.63 0.02294 0.01 0.98875 miRanda -0.24 0.03636 NA
131 hsa-miR-1275 BHLHE41 -0.09 0.78713 0.27 0.66334 MirTarget -0.2 0.00045 NA
132 hsa-miR-222-3p BMF 0.07 0.93415 -0.21 0.73035 miRNATAP -0.33 0 NA
133 hsa-miR-1275 BMP3 -0.09 0.78713 -0.26 0.66775 MirTarget -0.32 0.01405 NA
134 hsa-miR-1275 BMP6 -0.09 0.78713 0.13 0.63391 MirTarget -0.2 1.0E-5 NA
135 hsa-miR-320c BNIP3 -0.63 0.02294 0.24 0.69186 miRanda -0.26 0.00696 NA
136 hsa-miR-1275 BNIP3L -0.09 0.78713 -0.11 0.89144 MirTarget -0.11 0.00123 NA
137 hsa-miR-222-3p BPTF 0.07 0.93415 -0.18 0.83997 miRNAWalker2 validate -0.1 0.00117 NA
138 hsa-miR-222-3p BRWD3 0.07 0.93415 -0.33 0.5596 MirTarget; miRNATAP -0.11 0.04904 NA
139 hsa-miR-10a-5p BTBD11 -0.1 0.96336 0.08 0.82176 miRNATAP -0.28 0.00896 NA
140 hsa-miR-320c BVES -0.63 0.02294 0.04 0.90028 miRanda; miRNATAP -0.21 0.00532 NA
141 hsa-miR-125b-5p C18orf25 0.01 0.99458 -0 0.99358 miRNATAP -0.11 2.0E-5 NA
142 hsa-miR-1226-3p C1QTNF9 -0.15 0.57422 0.18 0.68883 MirTarget -0.28 0.00216 NA
143 hsa-miR-590-3p C1QTNF9 0.08 0.81071 0.18 0.68883 miRanda -0.24 0.01505 NA
144 hsa-miR-1275 C2CD4C -0.09 0.78713 -0.28 0.40511 MirTarget -0.29 1.0E-5 NA
145 hsa-miR-222-3p C3orf70 0.07 0.93415 -0.01 0.99084 miRNATAP -0.41 5.0E-5 NA
146 hsa-miR-1275 C5AR1 -0.09 0.78713 0.24 0.62896 MirTarget -0.26 1.0E-5 NA
147 hsa-miR-320c C5AR1 -0.63 0.02294 0.24 0.62896 miRanda -0.17 0.02094 NA
148 hsa-miR-140-5p C7 0.05 0.94453 -0.02 0.97498 miRanda -0.56 0.04072 NA
149 hsa-miR-193a-3p C7 -0.08 0.83305 -0.02 0.97498 miRanda -0.57 0.0011 NA
150 hsa-miR-375 C7 -0.13 0.94672 -0.02 0.97498 miRanda; miRNATAP -0.57 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 BIOLOGICAL ADHESION 112 1032 1.174e-16 5.464e-13
2 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 105 1021 4.2e-14 9.772e-11
3 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 147 1672 1.078e-13 1.401e-10
4 REGULATION OF CELLULAR COMPONENT MOVEMENT 86 771 1.204e-13 1.401e-10
5 CELL DEVELOPMENT 128 1426 1.296e-12 1.206e-09
6 POSITIVE REGULATION OF LOCOMOTION 56 420 2.698e-12 2.092e-09
7 NEUROGENESIS 124 1402 8.341e-12 5.121e-09
8 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 107 1142 8.805e-12 5.121e-09
9 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 123 1395 1.259e-11 6.51e-09
10 CELL CELL ADHESION 69 608 1.665e-11 7.209e-09
11 REGULATION OF CELL PROLIFERATION 129 1496 1.704e-11 7.209e-09
12 LOCOMOTION 104 1114 2.205e-11 8.55e-09
13 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 114 1275 3.314e-11 1.186e-08
14 CELL MOTILITY 84 835 5.572e-11 1.723e-08
15 LOCALIZATION OF CELL 84 835 5.572e-11 1.723e-08
16 RESPONSE TO OXYGEN CONTAINING COMPOUND 120 1381 5.923e-11 1.723e-08
17 POSITIVE REGULATION OF RESPONSE TO STIMULUS 153 1929 1.002e-10 2.591e-08
18 CARDIOVASCULAR SYSTEM DEVELOPMENT 80 788 1.058e-10 2.591e-08
19 CIRCULATORY SYSTEM DEVELOPMENT 80 788 1.058e-10 2.591e-08
20 VASCULATURE DEVELOPMENT 56 469 2.124e-10 4.941e-08
21 POSITIVE REGULATION OF CELL PROLIFERATION 80 814 5.01e-10 1.11e-07
22 TISSUE DEVELOPMENT 125 1518 7.071e-10 1.496e-07
23 REGULATION OF CELL DIFFERENTIATION 123 1492 9.209e-10 1.863e-07
24 SINGLE ORGANISM CELL ADHESION 53 459 2.163e-09 4.194e-07
25 RESPONSE TO ENDOGENOUS STIMULUS 119 1450 2.345e-09 4.364e-07
26 BLOOD VESSEL MORPHOGENESIS 45 364 4.402e-09 7.879e-07
27 REGULATION OF EPITHELIAL CELL PROLIFERATION 38 285 9.049e-09 1.56e-06
28 POSITIVE REGULATION OF CELL DIFFERENTIATION 77 823 9.592e-09 1.594e-06
29 NEURON DIFFERENTIATION 80 874 1.291e-08 2.072e-06
30 CELL JUNCTION ORGANIZATION 29 185 1.426e-08 2.212e-06
31 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 55 513 1.512e-08 2.27e-06
32 REGULATION OF AXONOGENESIS 27 168 2.609e-08 3.793e-06
33 CELLULAR COMPONENT MORPHOGENESIS 80 900 4.618e-08 6.511e-06
34 POSITIVE REGULATION OF CELL COMMUNICATION 119 1532 5.336e-08 7.302e-06
35 MULTICELLULAR ORGANISM METABOLIC PROCESS 19 93 6.169e-08 8.202e-06
36 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 25 154 6.945e-08 8.504e-06
37 REGULATION OF CELL DEATH 115 1472 6.781e-08 8.504e-06
38 REGULATION OF VASCULATURE DEVELOPMENT 32 233 6.643e-08 8.504e-06
39 REGULATION OF NEURON DIFFERENTIATION 56 554 8.524e-08 1.017e-05
40 POSITIVE REGULATION OF AXONOGENESIS 16 69 1.058e-07 1.23e-05
41 NEURON PROJECTION DEVELOPMENT 55 545 1.175e-07 1.334e-05
42 MULTICELLULAR ORGANISMAL MACROMOLECULE METABOLIC PROCESS 17 79 1.37e-07 1.518e-05
43 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 72 801 1.454e-07 1.573e-05
44 REGULATION OF MEMBRANE POTENTIAL 40 343 1.571e-07 1.661e-05
45 CELL JUNCTION ASSEMBLY 22 129 1.727e-07 1.786e-05
46 ANGIOGENESIS 36 293 1.804e-07 1.825e-05
47 NEURON MIGRATION 20 110 2.123e-07 2.102e-05
48 CELLULAR CHEMICAL HOMEOSTASIS 56 570 2.199e-07 2.132e-05
49 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 68 750 2.375e-07 2.167e-05
50 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 135 1848 2.288e-07 2.167e-05
51 NEURON PROJECTION MORPHOGENESIS 44 402 2.359e-07 2.167e-05
52 REGULATION OF EXTENT OF CELL GROWTH 19 101 2.442e-07 2.185e-05
53 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 81 957 2.992e-07 2.626e-05
54 NEGATIVE REGULATION OF CELL DEATH 75 872 4.535e-07 3.908e-05
55 NEGATIVE REGULATION OF CELL PROLIFERATION 60 643 4.756e-07 4.023e-05
56 POSITIVE REGULATION OF AXON EXTENSION 11 36 5.273e-07 4.382e-05
57 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 85 1036 5.592e-07 4.486e-05
58 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 85 1036 5.592e-07 4.486e-05
59 RESPONSE TO HORMONE 76 893 5.714e-07 4.506e-05
60 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 83 1008 6.618e-07 5.132e-05
61 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 81 983 8.828e-07 6.734e-05
62 RESPONSE TO LIPID 75 888 9.089e-07 6.821e-05
63 NEURON DEVELOPMENT 62 687 9.557e-07 7.059e-05
64 CHEMICAL HOMEOSTASIS 74 874 9.824e-07 7.143e-05
65 INTRACELLULAR SIGNAL TRANSDUCTION 116 1572 1.114e-06 7.853e-05
66 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 90 1135 1.104e-06 7.853e-05
67 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 69 799 1.15e-06 7.866e-05
68 OSSIFICATION 31 251 1.135e-06 7.866e-05
69 REGULATION OF OSSIFICATION 25 178 1.172e-06 7.905e-05
70 STEM CELL DIFFERENTIATION 26 190 1.194e-06 7.937e-05
71 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 111 1492 1.323e-06 8.672e-05
72 MESENCHYMAL CELL DIFFERENTIATION 21 134 1.384e-06 8.946e-05
73 ION HOMEOSTASIS 54 576 1.551e-06 9.888e-05
74 RESPONSE TO ALCOHOL 39 362 1.682e-06 0.0001058
75 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 120 1656 1.769e-06 0.0001098
76 POSITIVE REGULATION OF OSSIFICATION 16 84 1.809e-06 0.0001107
77 CYCLIC NUCLEOTIDE METABOLIC PROCESS 13 57 2.019e-06 0.000122
78 REGULATION OF CELL SIZE 24 172 2.146e-06 0.000128
79 RESPONSE TO EXTERNAL STIMULUS 129 1821 2.246e-06 0.0001323
80 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 44 437 2.305e-06 0.0001341
81 CAMP METABOLIC PROCESS 10 34 2.579e-06 0.0001481
82 REGULATION OF PHOSPHORUS METABOLIC PROCESS 117 1618 2.679e-06 0.000152
83 REGULATION OF CELL DEVELOPMENT 70 836 2.877e-06 0.0001613
84 DIVALENT INORGANIC CATION HOMEOSTASIS 37 343 2.998e-06 0.0001661
85 MULTI MULTICELLULAR ORGANISM PROCESS 27 213 3.35e-06 0.0001834
86 RESPONSE TO GROWTH FACTOR 46 475 3.916e-06 0.0002094
87 MESENCHYME DEVELOPMENT 25 190 3.913e-06 0.0002094
88 REGULATION OF SYSTEM PROCESS 48 507 4.515e-06 0.0002387
89 REGULATION OF CELL MORPHOGENESIS 51 552 4.584e-06 0.0002396
90 CELLULAR HOMEOSTASIS 59 676 5.018e-06 0.0002594
91 REGULATION OF PROTEIN MODIFICATION PROCESS 121 1710 5.103e-06 0.0002609
92 RESPONSE TO ESTROGEN 27 218 5.208e-06 0.0002634
93 SKELETAL SYSTEM DEVELOPMENT 44 455 6.566e-06 0.0003285
94 BEHAVIOR 48 516 7.263e-06 0.0003595
95 POSITIVE REGULATION OF CELL DEVELOPMENT 45 472 7.466e-06 0.0003657
96 SUBSTRATE ADHESION DEPENDENT CELL SPREADING 10 38 7.819e-06 0.000379
97 REGULATION OF DEVELOPMENTAL GROWTH 32 289 8.04e-06 0.0003822
98 TISSUE MORPHOGENESIS 49 533 8.05e-06 0.0003822
99 NEGATIVE REGULATION OF LOCOMOTION 30 263 8.519e-06 0.0004004
100 MUSCLE STRUCTURE DEVELOPMENT 42 432 9.297e-06 0.0004326
101 REGULATION OF PHOSPHOLIPASE C ACTIVITY 10 39 1.007e-05 0.0004571
102 NEURAL CREST CELL DIFFERENTIATION 14 75 1.012e-05 0.0004571
103 NEGATIVE CHEMOTAXIS 10 39 1.007e-05 0.0004571
104 HOMOPHILIC CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 21 153 1.183e-05 0.0005295
105 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 35 337 1.265e-05 0.0005605
106 REGULATION OF EPITHELIAL CELL MIGRATION 22 166 1.304e-05 0.0005724
107 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 16 98 1.44e-05 0.0006261
108 POSITIVE REGULATION OF MAPK CASCADE 44 470 1.482e-05 0.0006385
109 SINGLE ORGANISM BEHAVIOR 38 384 1.65e-05 0.0006729
110 RESPONSE TO WOUNDING 50 563 1.663e-05 0.0006729
111 REGULATION OF ANATOMICAL STRUCTURE SIZE 44 472 1.646e-05 0.0006729
112 CELL PROLIFERATION 57 672 1.676e-05 0.0006729
113 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 21 156 1.601e-05 0.0006729
114 CELL SUBSTRATE JUNCTION ASSEMBLY 10 41 1.629e-05 0.0006729
115 LOCOMOTORY BEHAVIOR 23 181 1.678e-05 0.0006729
116 NEGATIVE REGULATION OF CELL DIFFERENTIATION 53 609 1.641e-05 0.0006729
117 POSITIVE REGULATION OF PURINE NUCLEOTIDE METABOLIC PROCESS 19 133 1.715e-05 0.0006762
118 POSITIVE REGULATION OF NUCLEOTIDE METABOLIC PROCESS 19 133 1.715e-05 0.0006762
119 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 58 689 1.765e-05 0.0006903
120 CELL PROJECTION ORGANIZATION 71 902 2.005e-05 0.0007774
121 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 133 1977 2.078e-05 0.0007993
122 CENTRAL NERVOUS SYSTEM DEVELOPMENT 69 872 2.221e-05 0.000847
123 POSITIVE REGULATION OF CELL GROWTH 20 148 2.389e-05 0.0008967
124 REGULATION OF RESPONSE TO STRESS 104 1468 2.39e-05 0.0008967
125 POSITIVE REGULATION OF NEURON DIFFERENTIATION 32 306 2.565e-05 0.0009492
126 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 69 876 2.57e-05 0.0009492
127 PROTEIN PHOSPHORYLATION 73 944 2.759e-05 0.001011
128 OSTEOBLAST DIFFERENTIATION 18 126 2.835e-05 0.001021
129 REGULATION OF NEURON PROJECTION DEVELOPMENT 39 408 2.817e-05 0.001021
130 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 21 162 2.853e-05 0.001021
131 GROWTH 39 410 3.142e-05 0.001116
132 POSITIVE REGULATION OF PHOSPHOLIPASE ACTIVITY 11 53 3.19e-05 0.001124
133 MUSCLE SYSTEM PROCESS 30 282 3.292e-05 0.001152
134 RESPONSE TO ORGANIC CYCLIC COMPOUND 71 917 3.419e-05 0.001187
135 REGULATION OF MAPK CASCADE 55 660 3.831e-05 0.00132
136 CELLULAR RESPONSE TO NITROGEN COMPOUND 45 505 4.017e-05 0.001364
137 CELL CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 24 204 4.007e-05 0.001364
138 POSITIVE REGULATION OF MOLECULAR FUNCTION 121 1791 4.265e-05 0.001435
139 RESPONSE TO ABIOTIC STIMULUS 77 1024 4.288e-05 0.001435
140 RESPONSE TO ISCHEMIA 8 29 4.425e-05 0.001471
141 CELL PART MORPHOGENESIS 53 633 4.663e-05 0.001528
142 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 71 926 4.662e-05 0.001528
143 REGULATION OF CELL PROJECTION ORGANIZATION 48 558 5.45e-05 0.001773
144 POSITIVE REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 9 38 5.558e-05 0.001783
145 CELLULAR RESPONSE TO GLUCAGON STIMULUS 9 38 5.558e-05 0.001783
146 POSITIVE REGULATION OF CATALYTIC ACTIVITY 105 1518 5.737e-05 0.00182
147 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 96 1360 5.748e-05 0.00182
148 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 18 133 5.891e-05 0.001852
149 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 67 867 6.027e-05 0.001882
150 RESPONSE TO ESTRADIOL 19 146 6.398e-05 0.001972
151 RESPONSE TO MECHANICAL STIMULUS 24 210 6.395e-05 0.001972
152 ACTIVATION OF ADENYLATE CYCLASE ACTIVITY 9 39 6.923e-05 0.002119
153 POSITIVE REGULATION OF ADENYLATE CYCLASE ACTIVITY 10 48 7.027e-05 0.002137
154 POSITIVE REGULATION OF CAMP METABOLIC PROCESS 14 89 7.431e-05 0.002245
155 HEAD DEVELOPMENT 57 709 7.49e-05 0.002248
156 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 35 368 7.893e-05 0.002354
157 HOMEOSTATIC PROCESS 94 1337 7.976e-05 0.002364
158 RESPONSE TO NITROGEN COMPOUND 66 859 8.108e-05 0.002388
159 EPITHELIUM DEVELOPMENT 71 945 8.765e-05 0.002565
160 MORPHOGENESIS OF AN EPITHELIUM 37 400 8.912e-05 0.002568
161 CAMP BIOSYNTHETIC PROCESS 6 17 8.907e-05 0.002568
162 REGULATION OF TRANSPORT 120 1804 8.94e-05 0.002568
163 POSITIVE REGULATION OF GENE EXPRESSION 116 1733 9.171e-05 0.002618
164 ENSHEATHMENT OF NEURONS 14 91 9.524e-05 0.002686
165 AXON ENSHEATHMENT 14 91 9.524e-05 0.002686
166 REGULATION OF ENDOTHELIAL CELL MIGRATION 16 114 9.634e-05 0.0027
167 REGULATION OF CYTOSOLIC CALCIUM ION CONCENTRATION 23 203 0.0001029 0.002866
168 RESPONSE TO STEROID HORMONE 43 497 0.0001155 0.003181
169 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 15 104 0.0001154 0.003181
170 POSITIVE REGULATION OF KINASE ACTIVITY 42 482 0.0001182 0.003236
171 POSITIVE REGULATION OF LYASE ACTIVITY 11 61 0.0001237 0.003365
172 MUSCLE CONTRACTION 25 233 0.0001267 0.003427
173 EXTRACELLULAR STRUCTURE ORGANIZATION 30 304 0.0001305 0.003491
174 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 118 1784 0.0001298 0.003491
175 AMEBOIDAL TYPE CELL MIGRATION 19 154 0.0001319 0.003506
176 CARBOHYDRATE DERIVATIVE BIOSYNTHETIC PROCESS 49 595 0.0001335 0.003526
177 MORPHOGENESIS OF A BRANCHING STRUCTURE 20 167 0.0001341 0.003526
178 FOREBRAIN CELL MIGRATION 11 62 0.000144 0.003764
179 CYCLIC NUCLEOTIDE BIOSYNTHETIC PROCESS 8 34 0.0001515 0.003939
180 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 82 1152 0.000155 0.004007
181 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 13 84 0.0001577 0.00402
182 RESPONSE TO KETONE 21 182 0.0001567 0.00402
183 LEARNING 17 131 0.0001581 0.00402
184 REGULATION OF CALCIUM ION TRANSPORT 23 209 0.0001596 0.004036
185 REGULATION OF CELLULAR COMPONENT SIZE 32 337 0.0001619 0.004064
186 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 50 616 0.0001625 0.004064
187 COGNITION 26 251 0.0001662 0.004134
188 POSITIVE REGULATION OF GROWTH 25 238 0.0001771 0.004382
189 PHOSPHORYLATION 86 1228 0.0001844 0.00454
190 REGULATION OF PHOSPHOLIPASE ACTIVITY 11 64 0.0001932 0.004731
191 RESPONSE TO OXYGEN LEVELS 30 311 0.0001949 0.004748
192 POSITIVE REGULATION OF CYCLIC NUCLEOTIDE METABOLIC PROCESS 15 109 0.000197 0.004774
193 TAXIS 40 464 0.0002129 0.005133
194 REGULATION OF ION TRANSPORT 48 592 0.0002237 0.005366
195 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 57 740 0.0002305 0.005499
196 SEMAPHORIN PLEXIN SIGNALING PATHWAY 8 36 0.0002321 0.005511
197 REGENERATION 19 161 0.0002367 0.005591
198 CARBOHYDRATE DERIVATIVE METABOLIC PROCESS 75 1047 0.0002451 0.00576
199 REGULATION OF KINASE ACTIVITY 59 776 0.0002527 0.005859
200 CELLULAR RESPONSE TO ACID CHEMICAL 20 175 0.0002531 0.005859
201 MODULATION OF SYNAPTIC TRANSMISSION 29 301 0.0002525 0.005859
202 POSITIVE REGULATION OF LIPASE ACTIVITY 11 66 0.0002559 0.005895
203 CYCLIC NUCLEOTIDE MEDIATED SIGNALING 9 46 0.0002671 0.006062
204 REGULATION OF OSTEOBLAST DIFFERENTIATION 15 112 0.0002668 0.006062
205 REGULATION OF CELL ADHESION 50 629 0.0002665 0.006062
206 RESPONSE TO CORTICOSTEROID 20 176 0.0002731 0.006148
207 LEUKOCYTE MIGRATION 26 259 0.0002735 0.006148
208 CELLULAR RESPONSE TO PEPTIDE 27 274 0.0002841 0.006295
209 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 27 274 0.0002841 0.006295
210 CAMP MEDIATED SIGNALING 8 37 0.000284 0.006295
211 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 117 1805 0.000309 0.006754
212 CELLULAR RESPONSE TO HORMONE STIMULUS 45 552 0.0003092 0.006754
213 TUBE DEVELOPMENT 45 552 0.0003092 0.006754
214 REGULATION OF CELL MATRIX ADHESION 13 90 0.0003186 0.006926
215 EPITHELIAL CELL CELL ADHESION 5 14 0.0003344 0.007218
216 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 11 68 0.0003351 0.007218
217 MUSCLE ORGAN DEVELOPMENT 27 277 0.000338 0.007248
218 REGULATION OF RESPONSE TO WOUNDING 36 413 0.000351 0.007492
219 POSITIVE REGULATION OF MAP KINASE ACTIVITY 22 207 0.0003592 0.007632
220 AGING 26 264 0.0003684 0.007755
221 REGULATION OF CHEMOTAXIS 20 180 0.0003675 0.007755
222 RESPONSE TO GLUCAGON 9 48 0.0003734 0.007826
223 ACTIVATION OF PROTEIN KINASE ACTIVITY 27 279 0.0003788 0.007903
224 REGULATION OF HYDROLASE ACTIVITY 90 1327 0.0003825 0.007946
225 REGULATION OF CALCIUM ION TRANSPORT INTO CYTOSOL 13 92 0.0003966 0.008202
226 REGULATION OF HOMEOSTATIC PROCESS 38 447 0.0003984 0.008203
227 REGULATION OF METAL ION TRANSPORT 30 325 0.0004138 0.008482
228 NEGATIVE REGULATION OF GENE EXPRESSION 99 1493 0.0004284 0.008743
229 REGULATION OF TRANSFERASE ACTIVITY 68 946 0.000432 0.008776
230 REGULATION OF MEMBRANE PERMEABILITY 11 70 0.0004338 0.008776
231 CELLULAR RESPONSE TO OXYGEN LEVELS 17 143 0.0004533 0.009131
232 RESPONSE TO PEPTIDE 35 404 0.0004715 0.009457
233 REGULATION OF TRANSPORTER ACTIVITY 21 198 0.0004975 0.009935
NumGOOverlapSizeP ValueAdj. P Value
1 CELL ADHESION MOLECULE BINDING 27 186 2.254e-07 0.0002094
2 PROTEIN COMPLEX BINDING 78 935 8.835e-07 0.0004104
3 MACROMOLECULAR COMPLEX BINDING 103 1399 5.217e-06 0.001616
4 INTEGRIN BINDING 17 105 8.795e-06 0.002043
5 RECEPTOR BINDING 105 1476 1.833e-05 0.003406
6 CHEMOREPELLENT ACTIVITY 8 27 2.491e-05 0.003857
7 CYCLASE ACTIVITY 7 22 4.856e-05 0.005639
8 GLYCOSAMINOGLYCAN BINDING 24 205 4.338e-05 0.005639
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 105 1151 6.818e-11 2.159e-08
2 NEURON PROJECTION 91 942 7.394e-11 2.159e-08
3 EXTRACELLULAR MATRIX 53 426 1.45e-10 2.793e-08
4 NEURON PART 111 1265 1.913e-10 2.793e-08
5 PROTEINACEOUS EXTRACELLULAR MATRIX 46 356 7.042e-10 8.225e-08
6 SOMATODENDRITIC COMPARTMENT 63 650 6.256e-08 6.089e-06
7 MEMBRANE REGION 94 1134 8.385e-08 6.996e-06
8 CELL CELL JUNCTION 43 383 1.593e-07 1.163e-05
9 CELL PROJECTION 130 1786 4.836e-07 3.138e-05
10 SYNAPSE 66 754 1.241e-06 7.249e-05
11 EXTRACELLULAR MATRIX COMPONENT 20 125 1.761e-06 9.349e-05
12 INTRINSIC COMPONENT OF PLASMA MEMBRANE 119 1649 2.405e-06 0.000108
13 DENDRITE 45 451 2.261e-06 0.000108
14 CELL SURFACE 65 757 2.864e-06 0.0001195
15 SYNAPSE PART 54 610 8.427e-06 0.0003281
16 AXON 41 418 9.582e-06 0.0003497
17 BASEMENT MEMBRANE 15 93 3.071e-05 0.0009964
18 PLASMA MEMBRANE REGION 72 929 2.914e-05 0.0009964
19 CELL BODY 44 494 4.929e-05 0.001515
20 SARCOLEMMA 17 125 8.806e-05 0.002518
21 CELL PROJECTION PART 71 946 9.053e-05 0.002518
22 POSTSYNAPSE 35 378 0.0001341 0.00356
23 ANCHORING JUNCTION 42 489 0.0001619 0.00411
24 COLLAGEN TRIMER 13 88 0.000254 0.00618
25 SYNAPTIC MEMBRANE 26 261 0.0003085 0.007207

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 PI3K_Akt_signaling_pathway_hsa04151 41 352 1.138e-07 5.919e-06
2 Focal_adhesion_hsa04510 27 199 8.874e-07 2.307e-05
3 cGMP_PKG_signaling_pathway_hsa04022 22 163 9.714e-06 0.0001684
4 Ras_signaling_pathway_hsa04014 26 232 4.509e-05 0.0004882
5 Rap1_signaling_pathway_hsa04015 24 206 4.694e-05 0.0004882
6 Cell_adhesion_molecules_.CAMs._hsa04514 18 145 0.0001814 0.001573
7 Hippo_signaling_pathway_hsa04390 18 154 0.0003846 0.002857
8 ECM_receptor_interaction_hsa04512 12 82 0.0004742 0.003082
9 cAMP_signaling_pathway_hsa04024 20 198 0.00123 0.007109
10 MAPK_signaling_pathway_hsa04010 26 295 0.001886 0.009805
11 Apelin_signaling_pathway_hsa04371 15 137 0.002203 0.01042
12 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 15 139 0.002539 0.011
13 FoxO_signaling_pathway_hsa04068 14 132 0.004068 0.01546
14 Apoptosis_multiple_species_hsa04215 6 33 0.004162 0.01546
15 TNF_signaling_pathway_hsa04668 12 108 0.005197 0.01801
16 Calcium_signaling_pathway_hsa04020 17 182 0.006114 0.01987
17 Cellular_senescence_hsa04218 15 160 0.009338 0.02856
18 TGF_beta_signaling_pathway_hsa04350 9 84 0.01805 0.05214
19 Gap_junction_hsa04540 9 88 0.02373 0.06495
20 mTOR_signaling_pathway_hsa04150 13 151 0.02791 0.07258
21 Oocyte_meiosis_hsa04114 11 124 0.03401 0.08422
22 p53_signaling_pathway_hsa04115 7 68 0.04201 0.09931
23 Cytokine_cytokine_receptor_interaction_hsa04060 19 270 0.05724 0.1294
24 Tight_junction_hsa04530 13 170 0.06192 0.1341
25 Apoptosis_hsa04210 11 138 0.06449 0.1341
26 Regulation_of_actin_cytoskeleton_hsa04810 15 208 0.07136 0.1427
27 Autophagy_animal_hsa04140 10 128 0.08378 0.1614
28 Wnt_signaling_pathway_hsa04310 11 146 0.08805 0.1635
29 HIF_1_signaling_pathway_hsa04066 8 100 0.1029 0.1845
30 ErbB_signaling_pathway_hsa04012 7 85 0.1091 0.189
31 Phospholipase_D_signaling_pathway_hsa04072 10 146 0.1571 0.2555
32 Hippo_signaling_pathway_multiple_species_hsa04392 3 29 0.1572 0.2555
33 Phagosome_hsa04145 10 152 0.187 0.2947
34 Mitophagy_animal_hsa04137 5 65 0.1955 0.2989
35 Neuroactive_ligand_receptor_interaction_hsa04080 16 278 0.2496 0.3707
36 Adherens_junction_hsa04520 5 72 0.2566 0.3707
37 NF_kappa_B_signaling_pathway_hsa04064 6 95 0.2969 0.4173
38 VEGF_signaling_pathway_hsa04370 4 59 0.3074 0.4207
39 Cell_cycle_hsa04110 7 124 0.3755 0.5006
40 Sphingolipid_signaling_pathway_hsa04071 6 118 0.4918 0.6152
41 Jak_STAT_signaling_pathway_hsa04630 8 162 0.5065 0.6152
42 Phosphatidylinositol_signaling_system_hsa04070 5 99 0.5093 0.6152
43 AMPK_signaling_pathway_hsa04152 6 121 0.5164 0.6152
44 Necroptosis_hsa04217 8 164 0.5206 0.6152
45 Endocytosis_hsa04144 11 244 0.6138 0.7093
46 Hedgehog_signaling_pathway_hsa04340 2 47 0.6608 0.747
47 Peroxisome_hsa04146 2 83 0.9099 0.9657
48 Lysosome_hsa04142 3 123 0.9357 0.9731

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

EMX2OS

 hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-103a-3p;hsa-miR-107;hsa-miR-1262;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-141-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-15a-5p;hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-186-5p;hsa-miR-188-3p;hsa-miR-193a-3p;hsa-miR-196a-5p;hsa-miR-196b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-26a-1-3p;hsa-miR-26a-2-3p;hsa-miR-26b-3p;hsa-miR-26b-5p;hsa-miR-27a-3p;hsa-miR-29a-3p;hsa-miR-29a-5p;hsa-miR-29b-3p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-374a-3p;hsa-miR-374b-5p;hsa-miR-424-5p;hsa-miR-425-5p;hsa-miR-486-5p;hsa-miR-505-3p;hsa-miR-532-3p;hsa-miR-548o-3p;hsa-miR-576-5p;hsa-miR-584-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-940;hsa-miR-942-5p 52 KIAA2022 Sponge network 0.3 0.65988 -0.292 0.5957 0.551
2

EMX2OS

 hsa-miR-103a-3p;hsa-miR-107;hsa-miR-1262;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-30d-3p;hsa-miR-374b-3p;hsa-miR-374b-5p;hsa-miR-378a-5p;hsa-miR-421;hsa-miR-424-5p;hsa-miR-532-3p;hsa-miR-577;hsa-miR-590-3p;hsa-miR-93-5p 17 TMEM100 Sponge network 0.3 0.65988 -0.168 0.68476 0.507
3

CECR7

 hsa-miR-103a-3p;hsa-miR-1262;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-320a;hsa-miR-429;hsa-miR-532-3p;hsa-miR-590-3p;hsa-miR-93-5p 11 TMEM100 Sponge network -0.206 0.73331 -0.168 0.68476 0.497
4

MIAT

 hsa-miR-153-3p;hsa-miR-17-5p;hsa-miR-192-5p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-224-5p;hsa-miR-24-2-5p;hsa-miR-29a-3p;hsa-miR-33a-5p;hsa-miR-452-5p 10 BCL2 Sponge network 0.29 0.50324 -0.443 0.34621 0.452
5

CECR7

 hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-103a-3p;hsa-miR-1262;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-141-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-15a-5p;hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-186-5p;hsa-miR-188-3p;hsa-miR-196a-5p;hsa-miR-196b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-23a-3p;hsa-miR-26a-1-3p;hsa-miR-26a-2-3p;hsa-miR-26b-3p;hsa-miR-26b-5p;hsa-miR-27a-3p;hsa-miR-29a-3p;hsa-miR-29a-5p;hsa-miR-29b-3p;hsa-miR-320a;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-361-5p;hsa-miR-425-5p;hsa-miR-429;hsa-miR-532-3p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-940;hsa-miR-942-5p 44 KIAA2022 Sponge network -0.206 0.73331 -0.292 0.5957 0.432
6

EMX2OS

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1304-5p;hsa-miR-130b-3p;hsa-miR-135b-5p;hsa-miR-15b-3p;hsa-miR-17-5p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-224-3p;hsa-miR-29b-1-5p;hsa-miR-301a-3p;hsa-miR-33a-5p;hsa-miR-33b-5p;hsa-miR-374b-3p;hsa-miR-452-5p;hsa-miR-454-3p;hsa-miR-590-3p;hsa-miR-93-5p 21 ASPA Sponge network 0.3 0.65988 -0.302 0.57461 0.421
7

CECR7

 hsa-miR-1254;hsa-miR-1275;hsa-miR-141-3p;hsa-miR-17-3p;hsa-miR-18a-3p;hsa-miR-18a-5p;hsa-miR-18b-5p;hsa-miR-194-3p;hsa-miR-200a-3p;hsa-miR-224-5p;hsa-miR-23a-3p;hsa-miR-29b-3p;hsa-miR-378a-3p;hsa-miR-500a-3p;hsa-miR-532-3p;hsa-miR-590-3p;hsa-miR-671-5p;hsa-miR-939-5p;hsa-miR-940 19 GNG7 Sponge network -0.206 0.73331 -0.081 0.79764 0.41
8

EMX2OS

 hsa-let-7f-2-3p;hsa-miR-200a-5p;hsa-miR-200b-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-33a-3p;hsa-miR-374b-5p;hsa-miR-584-5p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-744-3p 11 TXLNB Sponge network 0.3 0.65988 -0.324 0.32954 0.406
9

CECR7

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1304-5p;hsa-miR-130b-3p;hsa-miR-135b-5p;hsa-miR-15b-3p;hsa-miR-17-5p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-23a-3p;hsa-miR-29b-1-5p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-33a-5p;hsa-miR-33b-5p;hsa-miR-452-5p;hsa-miR-454-3p;hsa-miR-590-3p;hsa-miR-93-5p 21 ASPA Sponge network -0.206 0.73331 -0.302 0.57461 0.393
10

EMX2OS

 hsa-miR-1254;hsa-miR-1275;hsa-miR-141-3p;hsa-miR-17-3p;hsa-miR-185-3p;hsa-miR-18a-3p;hsa-miR-18a-5p;hsa-miR-18b-5p;hsa-miR-194-3p;hsa-miR-200a-3p;hsa-miR-224-5p;hsa-miR-29b-3p;hsa-miR-378a-3p;hsa-miR-500a-3p;hsa-miR-532-3p;hsa-miR-590-3p;hsa-miR-671-5p;hsa-miR-92a-3p;hsa-miR-939-5p;hsa-miR-940 20 GNG7 Sponge network 0.3 0.65988 -0.081 0.79764 0.368
11

MIAT

 hsa-miR-106b-5p;hsa-miR-1304-5p;hsa-miR-130b-3p;hsa-miR-135b-5p;hsa-miR-17-5p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-301a-3p;hsa-miR-33a-5p;hsa-miR-374b-3p;hsa-miR-452-5p;hsa-miR-454-3p 12 ASPA Sponge network 0.29 0.50324 -0.302 0.57461 0.346
12

EMX2OS

 hsa-miR-103a-3p;hsa-miR-107;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-148b-3p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-26b-5p;hsa-miR-27a-3p;hsa-miR-30d-3p;hsa-miR-424-5p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-942-5p 17 PDK4 Sponge network 0.3 0.65988 -0.099 0.8788 0.33
13

CECR7

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1254;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-18a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-222-5p;hsa-miR-224-5p;hsa-miR-331-3p;hsa-miR-423-3p;hsa-miR-502-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-625-5p;hsa-miR-7-1-3p;hsa-miR-93-5p 19 CBX7 Sponge network -0.206 0.73331 -0.131 0.84612 0.329
14

MEG3

 hsa-miR-103a-3p;hsa-miR-107;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-141-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-15a-5p;hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-186-5p;hsa-miR-196a-5p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29a-3p;hsa-miR-29a-5p;hsa-miR-29b-3p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-320c;hsa-miR-335-3p;hsa-miR-425-5p;hsa-miR-429;hsa-miR-532-3p;hsa-miR-576-5p;hsa-miR-625-3p;hsa-miR-942-5p;hsa-miR-96-5p 35 KIAA2022 Sponge network 0.551 0.09784 -0.292 0.5957 0.325
15

HCG11

 hsa-let-7a-3p;hsa-let-7g-3p;hsa-miR-141-3p;hsa-miR-142-5p;hsa-miR-200a-5p;hsa-miR-200b-5p;hsa-miR-338-5p;hsa-miR-511-5p;hsa-miR-590-3p;hsa-miR-7-1-3p 10 FGF13 Sponge network 0.052 0.93058 0.3 0.38472 0.302
16

HCG11

 hsa-let-7a-3p;hsa-miR-107;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-141-5p;hsa-miR-142-5p;hsa-miR-148a-5p;hsa-miR-15a-5p;hsa-miR-15b-3p;hsa-miR-15b-5p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-200a-3p;hsa-miR-26a-1-3p;hsa-miR-26b-3p;hsa-miR-26b-5p;hsa-miR-30d-3p;hsa-miR-330-3p;hsa-miR-33a-3p;hsa-miR-455-5p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-625-3p;hsa-miR-942-5p 26 KIAA2022 Sponge network 0.052 0.93058 -0.292 0.5957 0.288
17

MEG3

 hsa-miR-103a-3p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-30d-3p;hsa-miR-374b-3p;hsa-miR-429;hsa-miR-532-3p;hsa-miR-577;hsa-miR-93-5p 12 TMEM100 Sponge network 0.551 0.09784 -0.168 0.68476 0.283
18

EMX2OS

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-1254;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-18a-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-222-5p;hsa-miR-224-5p;hsa-miR-331-3p;hsa-miR-421;hsa-miR-502-5p;hsa-miR-505-3p;hsa-miR-577;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-625-5p;hsa-miR-7-1-3p;hsa-miR-93-5p 21 CBX7 Sponge network 0.3 0.65988 -0.131 0.84612 0.269
19

ZNF883

 hsa-let-7a-3p;hsa-let-7a-5p;hsa-let-7f-1-3p;hsa-miR-101-5p;hsa-miR-103a-3p;hsa-miR-107;hsa-miR-1262;hsa-miR-130b-5p;hsa-miR-141-5p;hsa-miR-148a-3p;hsa-miR-148a-5p;hsa-miR-15b-3p;hsa-miR-16-2-3p;hsa-miR-181b-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-186-5p;hsa-miR-188-3p;hsa-miR-196a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-26a-1-3p;hsa-miR-26a-2-3p;hsa-miR-26b-3p;hsa-miR-26b-5p;hsa-miR-27a-3p;hsa-miR-27b-3p;hsa-miR-29a-3p;hsa-miR-29a-5p;hsa-miR-29b-3p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-320c;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-425-5p;hsa-miR-576-5p;hsa-miR-584-5p;hsa-miR-942-5p 40 KIAA2022 Sponge network 1.009 0.03784 -0.292 0.5957 0.266
20

CECR7

 hsa-miR-151a-5p;hsa-miR-15a-5p;hsa-miR-186-5p;hsa-miR-222-3p;hsa-miR-29a-5p;hsa-miR-32-3p;hsa-miR-335-5p;hsa-miR-33a-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p 12 PELI2 Sponge network -0.206 0.73331 -0.085 0.86805 0.259
21

MIAT

 hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-15b-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-19b-3p;hsa-miR-26b-5p;hsa-miR-29a-3p;hsa-miR-374a-3p;hsa-miR-424-5p;hsa-miR-425-5p;hsa-miR-532-3p;hsa-miR-96-5p 13 KIAA2022 Sponge network 0.29 0.50324 -0.292 0.5957 0.256

Quest ID: 6abd92c7d71303c8535236649fa1af66