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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-10a-5p ACAA1 0.79 0.00059 -0.46 0.00059 miRNAWalker2 validate -0.13 0 NA
2 hsa-miR-590-3p ACADL 0.84 0.00129 -4.45 0 miRanda -0.42 0.00074 NA
3 hsa-miR-148a-3p ACOX1 2.31 0 -0.01 0.90133 mirMAP -0.1 0 NA
4 hsa-miR-15a-5p ACOX1 1.63 0 -0.01 0.90133 miRNATAP -0.12 8.0E-5 NA
5 hsa-miR-199a-3p ACOX1 1.68 0 -0.01 0.90133 PITA -0.14 0 NA
6 hsa-miR-199b-3p ACOX1 1.68 0 -0.01 0.90133 PITA -0.14 0 NA
7 hsa-miR-497-5p ACOX1 -0.05 0.78621 -0.01 0.90133 miRNATAP -0.11 5.0E-5 NA
8 hsa-miR-708-3p ACOX1 3.44 0 -0.01 0.90133 mirMAP -0.11 0 NA
9 hsa-miR-93-5p ACOX1 1.51 0 -0.01 0.90133 mirMAP -0.14 0 NA
10 hsa-miR-576-5p ACOX2 1.03 0 -0.57 0.05834 MirTarget -0.35 0 NA
11 hsa-miR-590-3p ACOX2 0.84 0.00129 -0.57 0.05834 miRanda -0.3 0 NA
12 hsa-miR-130b-3p ACSL1 1.83 0 -1.01 0 MirTarget; miRNATAP -0.12 0.00104 NA
13 hsa-miR-195-3p ACSL3 -1.33 0 0.2 0.18226 mirMAP -0.15 0 NA
14 hsa-miR-221-3p ACSL3 -0.1 0.65445 0.2 0.18226 miRNAWalker2 validate -0.14 1.0E-5 NA
15 hsa-miR-30b-5p ACSL3 0.36 0.13803 0.2 0.18226 mirMAP -0.1 0.00043 NA
16 hsa-miR-30c-5p ACSL3 -0.33 0.1236 0.2 0.18226 mirMAP -0.19 0 NA
17 hsa-miR-30e-3p ACSL3 -0.1 0.52624 0.2 0.18226 mirMAP -0.12 0.00592 NA
18 hsa-miR-339-5p ACSL3 0.54 0.04881 0.2 0.18226 miRanda -0.11 3.0E-5 NA
19 hsa-miR-342-3p ACSL3 -0.13 0.56103 0.2 0.18226 miRanda -0.18 0 NA
20 hsa-miR-106a-5p ACSL4 1.39 6.0E-5 -1.28 0 MirTarget; miRNATAP -0.14 1.0E-5 NA
21 hsa-miR-106b-5p ACSL4 1.47 0 -1.28 0 MirTarget; miRNATAP -0.2 6.0E-5 NA
22 hsa-miR-130a-3p ACSL4 0.88 0.00016 -1.28 0 MirTarget; miRNATAP -0.14 0.00174 NA
23 hsa-miR-130b-3p ACSL4 1.83 0 -1.28 0 MirTarget; miRNATAP -0.22 0 NA
24 hsa-miR-130b-5p ACSL4 1.54 0 -1.28 0 MirTarget -0.2 0 NA
25 hsa-miR-148a-3p ACSL4 2.31 0 -1.28 0 miRNATAP -0.12 0.00276 NA
26 hsa-miR-15a-5p ACSL4 1.63 0 -1.28 0 MirTarget; miRNATAP -0.31 0 NA
27 hsa-miR-16-1-3p ACSL4 1.5 0 -1.28 0 MirTarget -0.22 2.0E-5 NA
28 hsa-miR-17-5p ACSL4 2.07 0 -1.28 0 MirTarget; TargetScan; miRNATAP -0.24 0 NA
29 hsa-miR-181b-5p ACSL4 0.67 0.00024 -1.28 0 mirMAP -0.21 0.00017 NA
30 hsa-miR-181c-5p ACSL4 0.53 0.01259 -1.28 0 mirMAP -0.13 0.00924 NA
31 hsa-miR-186-5p ACSL4 0.85 0 -1.28 0 MirTarget; miRNATAP -0.24 0.00092 NA
32 hsa-miR-19a-3p ACSL4 2.12 0 -1.28 0 MirTarget; miRNATAP -0.23 0 NA
33 hsa-miR-19b-3p ACSL4 2.11 0 -1.28 0 MirTarget; miRNATAP -0.26 0 NA
34 hsa-miR-20a-5p ACSL4 2.65 0 -1.28 0 MirTarget; miRNATAP -0.24 0 NA
35 hsa-miR-26b-3p ACSL4 1.37 0 -1.28 0 MirTarget -0.15 0.00024 NA
36 hsa-miR-26b-5p ACSL4 0.72 5.0E-5 -1.28 0 mirMAP -0.19 0.00082 NA
37 hsa-miR-301a-3p ACSL4 2.7 0 -1.28 0 MirTarget; miRNATAP -0.23 0 NA
38 hsa-miR-335-3p ACSL4 1.51 0 -1.28 0 MirTarget; mirMAP -0.27 0 NA
39 hsa-miR-34a-5p ACSL4 1.41 0 -1.28 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.3 0 NA
40 hsa-miR-429 ACSL4 2.38 0 -1.28 0 miRanda; miRNATAP -0.24 0 NA
41 hsa-miR-450b-5p ACSL4 1.69 0 -1.28 0 MirTarget; PITA; mirMAP -0.11 0.00175 NA
42 hsa-miR-454-3p ACSL4 1.49 0 -1.28 0 MirTarget; miRNATAP -0.29 0 NA
43 hsa-miR-664a-3p ACSL4 0.44 0.02142 -1.28 0 mirMAP -0.3 0 NA
44 hsa-miR-7-1-3p ACSL4 2.61 0 -1.28 0 mirMAP -0.18 9.0E-5 NA
45 hsa-miR-93-5p ACSL4 1.51 0 -1.28 0 MirTarget; miRNATAP -0.27 0 NA
46 hsa-miR-128-3p ACSL5 1.04 0 0.21 0.49172 miRNAWalker2 validate -0.66 0 NA
47 hsa-miR-590-3p ACSL5 0.84 0.00129 0.21 0.49172 miRanda; mirMAP -0.18 0.00436 NA
48 hsa-miR-106a-5p ACSL6 1.39 6.0E-5 0.35 0.34401 mirMAP -0.16 0.00381 NA
49 hsa-miR-16-2-3p ACSL6 0.5 0.02636 0.35 0.34401 mirMAP -0.22 0.00712 NA
50 hsa-miR-17-5p ACSL6 2.07 0 0.35 0.34401 mirMAP -0.3 2.0E-5 NA
51 hsa-miR-20a-5p ACSL6 2.65 0 0.35 0.34401 mirMAP -0.23 0.00057 NA
52 hsa-miR-582-5p ACSL6 1.08 0.00149 0.35 0.34401 mirMAP; miRNATAP -0.17 0.00073 NA
53 hsa-miR-193a-3p AQP7 0.55 0.0319 -0.68 0.21739 miRanda -0.55 0 NA
54 hsa-miR-28-5p CD36 1.2 0 -3.79 0 miRanda -0.6 0 NA
55 hsa-miR-590-3p CD36 0.84 0.00129 -3.79 0 miRanda -0.35 3.0E-5 NA
56 hsa-miR-629-3p CD36 1.32 0.00011 -3.79 0 MirTarget -0.25 1.0E-5 NA
57 hsa-miR-96-5p CD36 3.04 0 -3.79 0 MirTarget -0.57 0 NA
58 hsa-miR-155-5p CPT1A 0.81 0.00061 -0.73 1.0E-5 miRNAWalker2 validate -0.11 0.00071 NA
59 hsa-miR-17-5p CPT1A 2.07 0 -0.73 1.0E-5 mirMAP -0.11 0.00045 NA
60 hsa-miR-199a-5p CPT1A 1.31 0 -0.73 1.0E-5 miRanda -0.13 6.0E-5 NA
61 hsa-miR-20a-5p CPT1A 2.65 0 -0.73 1.0E-5 mirMAP -0.13 0 NA
62 hsa-miR-3613-5p CPT1A 0.02 0.93473 -0.73 1.0E-5 mirMAP -0.12 6.0E-5 NA
63 hsa-miR-455-5p CPT1A 1.37 0 -0.73 1.0E-5 miRanda -0.12 0.00027 NA
64 hsa-miR-93-5p CPT1A 1.51 0 -0.73 1.0E-5 mirMAP -0.11 0.00184 NA
65 hsa-miR-139-3p CPT1B -4 0 1.98 0 PITA -0.31 0 NA
66 hsa-miR-330-3p CPT1B -0.72 0.0008 1.98 0 miRNATAP -0.43 0 NA
67 hsa-miR-664a-3p EHHADH 0.44 0.02142 0.01 0.9632 mirMAP -0.19 1.0E-5 NA
68 hsa-miR-589-3p FABP4 1.34 2.0E-5 -6.28 0 MirTarget -0.32 0.00021 NA
69 hsa-miR-590-3p FABP4 0.84 0.00129 -6.28 0 miRanda -0.54 1.0E-5 NA
70 hsa-miR-429 FABP5 2.38 0 -2.4 0 miRanda -0.24 0 NA
71 hsa-let-7b-5p FADS2 -1.62 0 -0.21 0.49738 miRNAWalker2 validate -0.24 0.00036 NA
72 hsa-miR-125b-5p FADS2 -0.55 0.01072 -0.21 0.49738 mirMAP -0.25 0.00015 NA
73 hsa-miR-224-3p FADS2 0.92 0.01001 -0.21 0.49738 mirMAP -0.14 0.00053 NA
74 hsa-miR-26b-5p FADS2 0.72 5.0E-5 -0.21 0.49738 miRNAWalker2 validate -0.23 0.00394 NA
75 hsa-miR-335-5p FADS2 -0.47 0.0677 -0.21 0.49738 miRNAWalker2 validate -0.17 0.00633 NA
76 hsa-miR-450b-5p GK 1.69 0 -0.14 0.55876 MirTarget -0.17 1.0E-5 NA
77 hsa-miR-542-3p GK 1.62 0 -0.14 0.55876 miRanda -0.19 2.0E-5 NA
78 hsa-miR-590-5p HMGCS2 2.07 0 -3.01 0.00014 miRanda -0.48 0.00259 NA
79 hsa-miR-335-3p ILK 1.51 0 -0.61 0 MirTarget -0.16 0 NA
80 hsa-miR-155-5p LPL 0.81 0.00061 -3.16 0 miRNAWalker2 validate -0.35 8.0E-5 NA
81 hsa-miR-29b-3p LPL 3.11 0 -3.16 0 miRNATAP -0.27 0.00022 NA
82 hsa-miR-590-3p LPL 0.84 0.00129 -3.16 0 miRanda; mirMAP; miRNATAP -0.52 0 NA
83 hsa-miR-146b-5p ME1 1.09 1.0E-5 0.15 0.58684 miRanda -0.15 0.00474 NA
84 hsa-miR-3065-5p ME1 0.65 0.09995 0.15 0.58684 miRNATAP -0.11 0.00128 NA
85 hsa-miR-30c-5p ME1 -0.33 0.1236 0.15 0.58684 miRNATAP -0.19 0.00164 NA
86 hsa-miR-34a-5p ME1 1.41 0 0.15 0.58684 miRNAWalker2 validate -0.25 3.0E-5 NA
87 hsa-miR-326 MMP1 -0.99 0.00335 4.3 0 miRanda -0.27 0.00179 NA
88 hsa-miR-129-5p OLR1 -0.41 0.34149 -2.94 0 miRanda -0.1 0.00791 NA
89 hsa-miR-21-5p OLR1 4.38 0 -2.94 0 miRNAWalker2 validate -0.29 0 NA
90 hsa-miR-320b OLR1 0.23 0.37882 -2.94 0 miRanda -0.32 0 NA
91 hsa-miR-335-3p OLR1 1.51 0 -2.94 0 mirMAP -0.39 0 NA
92 hsa-miR-590-3p OLR1 0.84 0.00129 -2.94 0 miRanda; mirMAP -0.25 0.00125 NA
93 hsa-miR-590-5p OLR1 2.07 0 -2.94 0 miRanda -0.37 0 NA
94 hsa-miR-96-5p OLR1 3.04 0 -2.94 0 MirTarget -0.46 0 NA
95 hsa-miR-24-3p PCK2 -0.04 0.78587 -0.33 0.0252 miRNAWalker2 validate -0.16 0.00256 NA
96 hsa-miR-106b-5p PDPK1 1.47 0 -0.26 0.03408 mirMAP -0.13 0 NA
97 hsa-miR-128-3p PDPK1 1.04 0 -0.26 0.03408 miRNAWalker2 validate -0.16 0 NA
98 hsa-miR-16-5p PDPK1 0.75 0 -0.26 0.03408 mirMAP -0.12 0.00072 NA
99 hsa-miR-17-5p PDPK1 2.07 0 -0.26 0.03408 miRNAWalker2 validate; mirMAP -0.11 1.0E-5 NA
100 hsa-miR-185-5p PDPK1 1.14 0 -0.26 0.03408 miRNAWalker2 validate -0.11 0.0017 NA
101 hsa-miR-186-5p PDPK1 0.85 0 -0.26 0.03408 mirMAP -0.11 0.00858 NA
102 hsa-miR-22-5p PDPK1 1.71 0 -0.26 0.03408 miRNATAP -0.12 0 NA
103 hsa-miR-421 PDPK1 0.17 0.53528 -0.26 0.03408 mirMAP -0.13 0 NA
104 hsa-miR-424-5p PDPK1 1.26 1.0E-5 -0.26 0.03408 mirMAP -0.11 0 NA
105 hsa-miR-590-3p PDPK1 0.84 0.00129 -0.26 0.03408 miRanda; miRNATAP -0.15 0 NA
106 hsa-miR-590-5p PDPK1 2.07 0 -0.26 0.03408 miRanda -0.14 0 NA
107 hsa-miR-18a-5p PPARA 1.37 1.0E-5 0.11 0.39154 mirMAP -0.11 0 NA
108 hsa-miR-342-3p PPARA -0.13 0.56103 0.11 0.39154 miRanda -0.13 0 NA
109 hsa-miR-130b-3p PPARG 1.83 0 -2.13 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.37 0 NA
110 hsa-miR-20a-5p PPARG 2.65 0 -2.13 0 miRTarBase -0.27 2.0E-5 NA
111 hsa-miR-27b-3p PPARG 0.24 0.12264 -2.13 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.39 0.00039 NA
112 hsa-miR-301a-3p PPARG 2.7 0 -2.13 0 MirTarget; miRNATAP -0.23 7.0E-5 NA
113 hsa-miR-324-5p PPARG 1.07 5.0E-5 -2.13 0 miRanda -0.28 1.0E-5 NA
114 hsa-miR-429 PPARG 2.38 0 -2.13 0 miRNATAP -0.29 0 NA
115 hsa-miR-454-3p PPARG 1.49 0 -2.13 0 MirTarget; miRNATAP -0.27 0.00035 NA
116 hsa-let-7a-2-3p RXRG 1.34 0.00037 -4.18 0 MirTarget -0.28 7.0E-5 NA
117 hsa-let-7g-3p RXRG 2.38 0 -4.18 0 MirTarget; miRNATAP -0.44 0 NA
118 hsa-let-7i-5p SCD 0.61 0 -1.03 5.0E-5 MirTarget; miRNATAP -0.28 0.00359 NA
119 hsa-miR-10a-5p SCD 0.79 0.00059 -1.03 5.0E-5 miRNAWalker2 validate -0.18 0.00055 NA
120 hsa-miR-140-5p SCD 0.67 0.00034 -1.03 5.0E-5 MirTarget; PITA -0.19 0.00277 NA
121 hsa-miR-142-3p SCD 3.98 0 -1.03 5.0E-5 miRanda -0.12 0.00043 NA
122 hsa-miR-145-3p SCD -0.69 0.00068 -1.03 5.0E-5 mirMAP -0.15 0.00991 NA
123 hsa-miR-146a-5p SCD 0.68 0.01053 -1.03 5.0E-5 mirMAP -0.19 2.0E-5 24561623 miR-146a targets Numb to stabilize β-catenin which forms a feedback circuit to maintain Wnt activity and directs SCD
124 hsa-miR-181a-5p SCD -0.38 0.05621 -1.03 5.0E-5 miRNAWalker2 validate; MirTarget -0.29 0 NA
125 hsa-miR-181b-5p SCD 0.67 0.00024 -1.03 5.0E-5 MirTarget -0.3 0 NA
126 hsa-miR-181c-5p SCD 0.53 0.01259 -1.03 5.0E-5 MirTarget -0.23 5.0E-5 NA
127 hsa-miR-181d-5p SCD 1.19 0 -1.03 5.0E-5 MirTarget -0.2 0.00028 NA
128 hsa-miR-199a-3p SCD 1.68 0 -1.03 5.0E-5 MirTarget; PITA; miRNATAP -0.28 0 NA
129 hsa-miR-199b-3p SCD 1.68 0 -1.03 5.0E-5 MirTarget; PITA; miRNATAP -0.28 0 NA
130 hsa-miR-200b-3p SCD 1.55 0 -1.03 5.0E-5 MirTarget; TargetScan -0.16 0.00033 NA
131 hsa-miR-34c-3p SCD -1.35 0.00619 -1.03 5.0E-5 mirMAP -0.13 0 NA
132 hsa-miR-429 SCD 2.38 0 -1.03 5.0E-5 MirTarget; PITA; miRanda; miRNATAP -0.16 4.0E-5 NA
133 hsa-miR-452-5p SCD 0.64 0.04582 -1.03 5.0E-5 mirMAP -0.1 0.0068 NA
134 hsa-miR-664a-3p SCD 0.44 0.02142 -1.03 5.0E-5 mirMAP -0.19 0.00158 NA
135 hsa-miR-664a-5p SCD -0.09 0.66227 -1.03 5.0E-5 MirTarget -0.22 0.0001 NA
136 hsa-miR-141-3p SCD5 3.37 0 -2.12 0 TargetScan -0.34 0 NA
137 hsa-miR-16-2-3p SCD5 0.5 0.02636 -2.12 0 mirMAP -0.2 0.00789 NA
138 hsa-miR-17-5p SCD5 2.07 0 -2.12 0 TargetScan -0.3 0 NA
139 hsa-miR-324-5p SCD5 1.07 5.0E-5 -2.12 0 miRNAWalker2 validate -0.19 0.00133 NA
140 hsa-miR-590-5p SCD5 2.07 0 -2.12 0 miRanda -0.2 0.00297 NA
141 hsa-miR-629-3p SCD5 1.32 0.00011 -2.12 0 MirTarget -0.14 0.00358 NA
142 hsa-miR-193a-3p SCP2 0.55 0.0319 -0.17 0.16051 MirTarget; miRanda -0.1 1.0E-5 NA
143 hsa-miR-590-5p SCP2 2.07 0 -0.17 0.16051 mirMAP -0.13 0 NA
144 hsa-miR-185-3p SLC27A1 -0.38 0.09365 -0.39 0.03469 MirTarget -0.21 0 NA
145 hsa-miR-18a-5p SLC27A1 1.37 1.0E-5 -0.39 0.03469 mirMAP -0.17 0 NA
146 hsa-miR-421 SLC27A1 0.17 0.53528 -0.39 0.03469 miRanda; mirMAP -0.31 0 NA
147 hsa-miR-940 SLC27A1 0.01 0.97493 -0.39 0.03469 MirTarget -0.11 0.0001 NA
148 hsa-let-7b-5p SLC27A2 -1.62 0 1.08 0.00231 miRNAWalker2 validate -0.31 6.0E-5 NA
149 hsa-let-7g-3p SORBS1 2.38 0 -1.8 0 miRNATAP -0.27 0 NA
150 hsa-miR-142-5p SORBS1 1.3 0 -1.8 0 PITA; miRNATAP -0.17 6.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 FATTY ACID METABOLIC PROCESS 21 296 8.396e-30 3.907e-26
2 CELLULAR LIPID METABOLIC PROCESS 25 913 8.291e-26 1.929e-22
3 MONOCARBOXYLIC ACID METABOLIC PROCESS 21 503 6.698e-25 8.731e-22
4 LIPID METABOLIC PROCESS 26 1158 7.505e-25 8.731e-22
5 LONG CHAIN FATTY ACID METABOLIC PROCESS 13 88 1.954e-22 1.818e-19
6 ORGANIC ACID METABOLIC PROCESS 22 953 1.314e-20 1.019e-17
7 SMALL MOLECULE METABOLIC PROCESS 26 1767 3.57e-20 2.373e-17
8 FATTY ACID TRANSPORT 10 56 3.044e-18 1.771e-15
9 CELLULAR LIPID CATABOLIC PROCESS 12 151 2.357e-17 1.218e-14
10 LIPID OXIDATION 10 70 3.336e-17 1.552e-14
11 FATTY ACID BETA OXIDATION 9 51 1.932e-16 8.173e-14
12 LONG CHAIN FATTY ACID TRANSPORT 8 42 5.399e-15 2.094e-12
13 FATTY ACID CATABOLIC PROCESS 9 73 6.003e-15 2.149e-12
14 LIPID CATABOLIC PROCESS 12 247 9.275e-15 3.083e-12
15 MONOCARBOXYLIC ACID TRANSPORT 10 124 1.287e-14 3.992e-12
16 MONOCARBOXYLIC ACID CATABOLIC PROCESS 9 96 7.795e-14 2.267e-11
17 LIPID BIOSYNTHETIC PROCESS 14 539 1.987e-13 5.439e-11
18 LIPID LOCALIZATION 11 264 7.725e-13 1.997e-10
19 LIPID MODIFICATION 10 210 2.633e-12 6.447e-10
20 FATTY ACYL COA METABOLIC PROCESS 7 51 3.602e-12 8.381e-10
21 ACYL COA BIOSYNTHETIC PROCESS 7 54 5.489e-12 1.161e-09
22 THIOESTER BIOSYNTHETIC PROCESS 7 54 5.489e-12 1.161e-09
23 SMALL MOLECULE BIOSYNTHETIC PROCESS 12 443 9.306e-12 1.883e-09
24 OXIDATION REDUCTION PROCESS 15 898 1.245e-11 2.414e-09
25 ALPHA LINOLENIC ACID METABOLIC PROCESS 5 13 1.802e-11 3.353e-09
26 ORGANIC ACID TRANSPORT 10 261 2.274e-11 4.07e-09
27 SINGLE ORGANISM BIOSYNTHETIC PROCESS 17 1340 2.537e-11 4.373e-09
28 ORGANIC ANION TRANSPORT 11 387 4.814e-11 7.999e-09
29 COENZYME BIOSYNTHETIC PROCESS 8 127 5.514e-11 8.848e-09
30 CARBOXYLIC ACID CATABOLIC PROCESS 9 205 7.76e-11 1.165e-08
31 ORGANIC ACID CATABOLIC PROCESS 9 205 7.76e-11 1.165e-08
32 THIOESTER METABOLIC PROCESS 7 83 1.24e-10 1.749e-08
33 ACYL COA METABOLIC PROCESS 7 83 1.24e-10 1.749e-08
34 NEUTRAL LIPID METABOLIC PROCESS 7 85 1.471e-10 2.013e-08
35 SMALL MOLECULE CATABOLIC PROCESS 10 328 2.138e-10 2.843e-08
36 SINGLE ORGANISM CATABOLIC PROCESS 14 957 4.253e-10 5.497e-08
37 COFACTOR BIOSYNTHETIC PROCESS 8 166 4.721e-10 5.937e-08
38 MONOCARBOXYLIC ACID BIOSYNTHETIC PROCESS 8 172 6.263e-10 7.669e-08
39 ANION TRANSPORT 11 507 8.449e-10 1.002e-07
40 UNSATURATED FATTY ACID METABOLIC PROCESS 7 109 8.612e-10 1.002e-07
41 REGULATION OF LIPID METABOLIC PROCESS 9 282 1.308e-09 1.485e-07
42 CELLULAR CATABOLIC PROCESS 15 1322 2.758e-09 3.056e-07
43 FATTY ACID BETA OXIDATION USING ACYL COA OXIDASE 4 13 6.247e-09 6.606e-07
44 REGULATION OF CHOLESTEROL STORAGE 4 13 6.247e-09 6.606e-07
45 ORGANIC HYDROXY COMPOUND METABOLIC PROCESS 10 482 8.728e-09 9.025e-07
46 CATABOLIC PROCESS 16 1773 1.785e-08 1.806e-06
47 COENZYME METABOLIC PROCESS 8 265 1.876e-08 1.858e-06
48 CARBOXYLIC ACID BIOSYNTHETIC PROCESS 8 270 2.17e-08 2.06e-06
49 ORGANIC ACID BIOSYNTHETIC PROCESS 8 270 2.17e-08 2.06e-06
50 LIPID HOMEOSTASIS 6 110 4.108e-08 3.823e-06
51 SULFUR COMPOUND BIOSYNTHETIC PROCESS 7 203 6.509e-08 5.938e-06
52 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 6 128 1.016e-07 9.095e-06
53 COFACTOR METABOLIC PROCESS 8 334 1.12e-07 9.835e-06
54 ION TRANSPORT 13 1262 1.392e-07 1.2e-05
55 REGULATION OF MACROPHAGE DERIVED FOAM CELL DIFFERENTIATION 4 28 1.755e-07 1.458e-05
56 REGULATION OF FATTY ACID OXIDATION 4 28 1.755e-07 1.458e-05
57 GLYCEROLIPID METABOLIC PROCESS 8 356 1.825e-07 1.49e-05
58 RESPONSE TO FATTY ACID 5 83 3.713e-07 2.978e-05
59 RESPONSE TO OXYGEN CONTAINING COMPOUND 13 1381 3.949e-07 3.114e-05
60 BILE ACID METABOLIC PROCESS 4 35 4.448e-07 3.449e-05
61 REGULATION OF FATTY ACID METABOLIC PROCESS 5 87 4.7e-07 3.585e-05
62 ORGANIC HYDROXY COMPOUND BIOSYNTHETIC PROCESS 6 175 6.452e-07 4.842e-05
63 REGULATION OF LIPID STORAGE 4 41 8.536e-07 6.305e-05
64 RESPONSE TO COLD 4 43 1.038e-06 7.544e-05
65 REGULATION OF SEQUESTERING OF TRIGLYCERIDE 3 12 1.165e-06 8.341e-05
66 RESPONSE TO INSULIN 6 205 1.625e-06 0.0001145
67 FATTY ACID BIOSYNTHETIC PROCESS 5 114 1.803e-06 0.0001252
68 POSITIVE REGULATION OF FATTY ACID OXIDATION 3 14 1.923e-06 0.0001316
69 SULFUR COMPOUND METABOLIC PROCESS 7 359 3.02e-06 0.0002036
70 FATTY ACID BETA OXIDATION USING ACYL COA DEHYDROGENASE 3 18 4.29e-06 0.0002852
71 CELLULAR RESPONSE TO HORMONE STIMULUS 8 552 4.898e-06 0.000321
72 BILE ACID BIOSYNTHETIC PROCESS 3 20 5.978e-06 0.0003864
73 RESPONSE TO TEMPERATURE STIMULUS 5 148 6.497e-06 0.0004141
74 TRIGLYCERIDE CATABOLIC PROCESS 3 21 6.966e-06 0.000438
75 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 10 1008 7.745e-06 0.0004805
76 ORGANIC HYDROXY COMPOUND TRANSPORT 5 155 8.138e-06 0.0004982
77 HORMONE MEDIATED SIGNALING PATHWAY 5 158 8.933e-06 0.0005398
78 NEUTRAL LIPID CATABOLIC PROCESS 3 26 1.353e-05 0.0007971
79 ACYLGLYCEROL CATABOLIC PROCESS 3 26 1.353e-05 0.0007971
80 REGULATION OF CELLULAR KETONE METABOLIC PROCESS 5 173 1.387e-05 0.0008065
81 CHEMICAL HOMEOSTASIS 9 874 1.81e-05 0.001039
82 VERY LONG CHAIN FATTY ACID METABOLIC PROCESS 3 29 1.895e-05 0.001075
83 RESPONSE TO HORMONE 9 893 2.146e-05 0.001203
84 RESPONSE TO NUTRIENT 5 191 2.234e-05 0.001238
85 REGULATION OF LIPID TRANSPORT 4 95 2.504e-05 0.001371
86 POSITIVE REGULATION OF FATTY ACID METABOLIC PROCESS 3 33 2.816e-05 0.001523
87 RESPONSE TO ENDOGENOUS STIMULUS 11 1450 3.093e-05 0.001654
88 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO CELL PERIPHERY 3 37 3.99e-05 0.002063
89 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE 3 37 3.99e-05 0.002063
90 GLYCEROLIPID CATABOLIC PROCESS 3 37 3.99e-05 0.002063
91 ALCOHOL BIOSYNTHETIC PROCESS 4 111 4.616e-05 0.00236
92 STEROID BIOSYNTHETIC PROCESS 4 114 5.123e-05 0.002591
93 STEROID METABOLIC PROCESS 5 237 6.257e-05 0.003131
94 REGULATION OF PLASMA LIPOPROTEIN PARTICLE LEVELS 3 45 7.215e-05 0.003571
95 RESPONSE TO PEPTIDE 6 404 7.632e-05 0.003738
96 REGULATION OF LIPID BIOSYNTHETIC PROCESS 4 128 8.045e-05 0.003899
97 HOMEOSTATIC PROCESS 10 1337 8.799e-05 0.004178
98 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE 3 48 8.762e-05 0.004178
99 CELLULAR RESPONSE TO FATTY ACID 3 51 0.0001051 0.00494
100 RESPONSE TO DRUG 6 431 0.0001089 0.005067
101 RESPONSE TO EXTRACELLULAR STIMULUS 6 441 0.0001235 0.005688
102 CELLULAR RESPONSE TO INSULIN STIMULUS 4 146 0.0001339 0.006106
103 CELLULAR RESPONSE TO LIPID 6 457 0.0001499 0.006774
104 UNSATURATED FATTY ACID BIOSYNTHETIC PROCESS 3 58 0.0001544 0.006907
105 POSITIVE REGULATION OF MEMBRANE INVAGINATION 2 11 0.0001715 0.007528
106 POSITIVE REGULATION OF PHAGOCYTOSIS ENGULFMENT 2 11 0.0001715 0.007528
107 RESPONSE TO ORGANIC CYCLIC COMPOUND 8 917 0.0001823 0.007927
108 AMMONIUM ION METABOLIC PROCESS 4 169 0.0002347 0.009569
109 WHITE FAT CELL DIFFERENTIATION 2 13 0.0002427 0.009569
110 LIPOPROTEIN TRANSPORT 2 13 0.0002427 0.009569
111 REGULATION OF PHAGOCYTOSIS ENGULFMENT 2 13 0.0002427 0.009569
112 CARNITINE METABOLIC PROCESS 2 13 0.0002427 0.009569
113 LIPOPROTEIN LOCALIZATION 2 13 0.0002427 0.009569
114 NEGATIVE REGULATION OF MACROPHAGE DERIVED FOAM CELL DIFFERENTIATION 2 13 0.0002427 0.009569
115 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 4 168 0.0002294 0.009569
116 REGULATION OF PHOSPHOLIPID BIOSYNTHETIC PROCESS 2 13 0.0002427 0.009569
117 NEGATIVE REGULATION OF CARDIAC MUSCLE CELL APOPTOTIC PROCESS 2 13 0.0002427 0.009569
118 REGULATION OF MEMBRANE INVAGINATION 2 13 0.0002427 0.009569
119 RESPONSE TO ACID CHEMICAL 5 319 0.0002513 0.009827
NumGOOverlapSizeP ValueAdj. P Value
1 LONG CHAIN FATTY ACID COA LIGASE ACTIVITY 7 13 5.603e-17 5.206e-14
2 FATTY ACID LIGASE ACTIVITY 7 16 3.721e-16 1.729e-13
3 LIGASE ACTIVITY FORMING CARBON SULFUR BONDS 7 40 5.883e-13 1.822e-10
4 FATTY ACID BINDING 5 31 2.324e-09 5.397e-07
5 MONOCARBOXYLIC ACID BINDING 5 65 1.081e-07 2.009e-05
6 FATTY ACYL COA BINDING 4 31 2.686e-07 4.16e-05
7 OXIDOREDUCTASE ACTIVITY ACTING ON THE CH CH GROUP OF DONORS 4 57 3.262e-06 0.0003876
8 OXIDOREDUCTASE ACTIVITY 9 719 3.755e-06 0.0003876
9 ACYL COA DEHYDROGENASE ACTIVITY 3 17 3.579e-06 0.0003876
10 LIGASE ACTIVITY 7 406 6.773e-06 0.0006293
11 LIPID BINDING 8 657 1.741e-05 0.001348
12 COENZYME BINDING 5 179 1.635e-05 0.001348
13 ORGANIC ACID BINDING 5 209 3.44e-05 0.002459
14 ELECTRON CARRIER ACTIVITY 4 112 4.781e-05 0.003172
15 SULFUR COMPOUND BINDING 5 234 5.891e-05 0.003648
16 TRANSFERASE ACTIVITY TRANSFERRING ACYL GROUPS 5 249 7.903e-05 0.004588
17 TRANSCRIPTION FACTOR ACTIVITY DIRECT LIGAND REGULATED SEQUENCE SPECIFIC DNA BINDING 3 48 8.762e-05 0.004788
18 COFACTOR BINDING 5 263 0.0001022 0.005277
19 STEROID HORMONE RECEPTOR ACTIVITY 3 59 0.0001625 0.007943
20 FATTY ACID TRANSPORTER ACTIVITY 2 12 0.0002056 0.009094
21 RECEPTOR BINDING 10 1476 0.0001997 0.009094
22 LOW DENSITY LIPOPROTEIN RECEPTOR ACTIVITY 2 13 0.0002427 0.009928
23 ADENYL NUCLEOTIDE BINDING 10 1514 0.0002458 0.009928
NumGOOverlapSizeP ValueAdj. P Value
1 MICROBODY PART 10 93 6.611e-16 3.861e-13
2 MICROBODY 10 134 2.842e-14 8.298e-12
3 MITOCHONDRION 18 1633 5.175e-11 1.007e-08
4 MICROBODY MEMBRANE 6 58 8.301e-10 1.212e-07
5 OUTER MEMBRANE 8 190 1.379e-09 1.611e-07
6 MICROBODY LUMEN 5 45 1.641e-08 1.597e-06
7 MITOCHONDRIAL ENVELOPE 11 691 2.113e-08 1.763e-06
8 MITOCHONDRIAL PART 12 953 5.542e-08 4.046e-06
9 ENVELOPE 11 1090 2.04e-06 0.0001324
10 NUCLEAR OUTER MEMBRANE ENDOPLASMIC RETICULUM MEMBRANE NETWORK 9 1005 5.427e-05 0.003169
11 ENDOPLASMIC RETICULUM PART 9 1163 0.0001664 0.008832
12 LIPID PARTICLE 3 62 0.0001883 0.009164

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa03320_PPAR_signaling_pathway 36 70 6.093e-94 1.097e-91
2 hsa00071_Fatty_acid_metabolism 11 43 6.511e-22 5.86e-20
3 hsa04920_Adipocytokine_signaling_pathway 11 68 1.686e-19 1.012e-17
4 hsa04146_Peroxisome 11 79 9.814e-19 4.416e-17
5 hsa01040_Biosynthesis_of_unsaturated_fatty_acids 5 21 2.819e-10 1.015e-08
6 hsa00280_Valine._leucine_and_isoleucine_degradation 3 44 6.742e-05 0.002023
7 hsa00120_Primary_bile_acid_biosynthesis 2 16 0.0003721 0.009567
8 hsa00592_alpha.Linolenic_acid_metabolism 2 20 0.0005864 0.0132
9 hsa00650_Butanoate_metabolism 2 30 0.001328 0.02655
10 hsa04910_Insulin_signaling_pathway 3 138 0.001943 0.03497
11 hsa00620_Pyruvate_metabolism 2 40 0.002354 0.03851
12 hsa00561_Glycerolipid_metabolism 2 50 0.003655 0.05482
13 hsa04145_Phagosome 2 156 0.03203 0.3843
14 hsa04510_Focal_adhesion 2 200 0.0502 0.4988
15 hsa04151_PI3K_AKT_signaling_pathway 2 351 0.1312 0.8437

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 MAGI2-AS3 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-130b-5p;hsa-miR-15a-5p;hsa-miR-16-1-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-26b-3p;hsa-miR-301a-3p;hsa-miR-335-3p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-7-1-3p;hsa-miR-93-5p 18 ACSL4 Sponge network -1.892 0 -1.282 0 0.321
2 RP11-166D19.1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-130b-5p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-26b-3p;hsa-miR-301a-3p;hsa-miR-335-3p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-7-1-3p 15 ACSL4 Sponge network -0.582 0.05253 -1.282 0 0.307
3 LINC00702 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-130b-5p;hsa-miR-148a-3p;hsa-miR-15a-5p;hsa-miR-16-1-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-26b-3p;hsa-miR-301a-3p;hsa-miR-335-3p;hsa-miR-34a-5p;hsa-miR-450b-5p;hsa-miR-454-3p;hsa-miR-7-1-3p;hsa-miR-93-5p 20 ACSL4 Sponge network -2.856 0 -1.282 0 0.289
4 RP11-532F6.3 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-130b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-26b-3p;hsa-miR-301a-3p 10 ACSL4 Sponge network -2.028 0 -1.282 0 0.285
5 CTD-2013N24.2 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-130b-5p;hsa-miR-148a-3p;hsa-miR-15a-5p;hsa-miR-16-1-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-26b-3p;hsa-miR-301a-3p;hsa-miR-335-3p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-7-1-3p;hsa-miR-93-5p 19 ACSL4 Sponge network -1.745 0 -1.282 0 0.266
6 CTD-2269F5.1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-301a-3p;hsa-miR-7-1-3p;hsa-miR-93-5p 11 ACSL4 Sponge network -1.576 0.00334 -1.282 0 0.264
7

LINC00968

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-130b-5p;hsa-miR-148a-3p;hsa-miR-15a-5p;hsa-miR-16-1-3p;hsa-miR-17-5p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-26b-3p;hsa-miR-301a-3p;hsa-miR-450b-5p;hsa-miR-93-5p 16 ACSL4 Sponge network -4.19 0 -1.282 0 0.258

Quest ID: 6aeb46454fcdb2d47990fe30d4146f95