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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-301a-3p ABHD2 -0.76 0.09613 0.63 0.15716 mirMAP -0.32 0 NA
2 hsa-miR-301a-3p ABTB2 -0.76 0.09613 0.09 0.87066 mirMAP -0.41 0 NA
3 hsa-miR-301a-3p ACBD3 -0.76 0.09613 0.56 0.02656 MirTarget; miRNATAP -0.14 0.00051 NA
4 hsa-miR-301a-3p ACSL4 -0.76 0.09613 -0.57 0.06388 MirTarget; miRNATAP -0.17 0.00063 NA
5 hsa-miR-301a-3p ACVR1 -0.76 0.09613 0.3 0.22609 MirTarget; miRNATAP -0.18 1.0E-5 NA
6 hsa-miR-301a-3p ADAM12 -0.76 0.09613 -1.12 0.25198 miRNATAP -0.65 4.0E-5 NA
7 hsa-miR-301a-3p AGFG1 -0.76 0.09613 0.01 0.95401 MirTarget; miRNATAP -0.13 3.0E-5 NA
8 hsa-miR-301a-3p ANKRD28 -0.76 0.09613 -0.03 0.87325 MirTarget; miRNATAP -0.11 0.00066 NA
9 hsa-miR-301a-3p ANXA11 -0.76 0.09613 0.21 0.52584 mirMAP -0.29 0 NA
10 hsa-miR-301a-3p APBB2 -0.76 0.09613 -0.11 0.68147 mirMAP -0.13 0.00265 NA
11 hsa-miR-301a-3p APCDD1 -0.76 0.09613 0.26 0.63295 MirTarget -0.33 0.00017 NA
12 hsa-miR-301a-3p AR -0.76 0.09613 -0.52 0.55352 mirMAP; miRNATAP -0.4 0.00488 25940439 Mechanism dissection revealed infiltrating pre-adipocytes might function through down-regulation of the androgen receptor AR via modulation of miR-301a and then increase PCa cell invasion via induction of TGF-β1/Smad/MMP9 signals
13 hsa-miR-301a-3p ARAP2 -0.76 0.09613 -0.25 0.55742 MirTarget -0.34 0 NA
14 hsa-miR-301a-3p ARHGAP12 -0.76 0.09613 0.37 0.2122 miRNATAP -0.15 0.00123 NA
15 hsa-miR-301a-3p ARHGAP21 -0.76 0.09613 0.3 0.28692 MirTarget; miRNATAP -0.24 0 NA
16 hsa-miR-301a-3p ARHGAP26 -0.76 0.09613 0.27 0.55575 mirMAP -0.35 0 NA
17 hsa-miR-301a-3p ARL6IP1 -0.76 0.09613 0.51 0.12034 MirTarget -0.16 0.00307 NA
18 hsa-miR-301a-3p ATF6 -0.76 0.09613 0.23 0.30334 mirMAP -0.11 0.00271 NA
19 hsa-miR-301a-3p ATG16L1 -0.76 0.09613 0.32 0.16633 MirTarget; miRNATAP -0.14 0.00012 NA
20 hsa-miR-301a-3p ATP11A -0.76 0.09613 0.11 0.75717 MirTarget; miRNATAP -0.16 0.00587 NA
21 hsa-miR-301a-3p ATR -0.76 0.09613 -0.04 0.82153 mirMAP -0.1 0.00132 NA
22 hsa-miR-301a-3p ATXN1 -0.76 0.09613 -0.51 0.09797 miRNATAP -0.17 0.00057 NA
23 hsa-miR-301a-3p B4GALT5 -0.76 0.09613 0.16 0.60085 miRNATAP -0.15 0.00206 NA
24 hsa-miR-301a-3p BCL9L -0.76 0.09613 0.28 0.39221 mirMAP -0.16 0.00185 NA
25 hsa-miR-301a-3p BMPR1B -0.76 0.09613 0.22 0.768 miRNATAP -0.75 0 NA
26 hsa-miR-301a-3p BMPR2 -0.76 0.09613 -0.03 0.9248 MirTarget; miRNATAP -0.12 0.00892 NA
27 hsa-miR-301a-3p BTBD10 -0.76 0.09613 0.37 0.08561 MirTarget -0.11 0.00144 NA
28 hsa-miR-301a-3p BTN2A2 -0.76 0.09613 -1.12 0.00207 mirMAP -0.18 0.00333 NA
29 hsa-miR-301a-3p C15orf52 -0.76 0.09613 0.11 0.85147 mirMAP -0.25 0.00658 NA
30 hsa-miR-301a-3p C1S -0.76 0.09613 -0.53 0.36559 MirTarget -0.5 0 NA
31 hsa-miR-301a-3p C2orf49 -0.76 0.09613 0.24 0.24355 mirMAP -0.22 0 NA
32 hsa-miR-301a-3p CA13 -0.76 0.09613 1.34 0.0047 MirTarget -0.22 0.00456 NA
33 hsa-miR-301a-3p CAMK4 -0.76 0.09613 -0.61 0.35184 mirMAP -0.31 0.00432 NA
34 hsa-miR-301a-3p CCDC50 -0.76 0.09613 -0.36 0.09894 mirMAP -0.12 0.00086 NA
35 hsa-miR-301a-3p CCDC6 -0.76 0.09613 -0.08 0.72287 MirTarget -0.15 4.0E-5 NA
36 hsa-miR-301a-3p CCNA2 -0.76 0.09613 0.67 0.16545 miRNATAP -0.2 0.00997 NA
37 hsa-miR-301a-3p CD109 -0.76 0.09613 0.78 0.26548 mirMAP -0.44 0.0001 NA
38 hsa-miR-301a-3p CDC73 -0.76 0.09613 0.22 0.34941 miRNATAP -0.13 0.00064 NA
39 hsa-miR-301a-3p CDH11 -0.76 0.09613 -0.6 0.41785 mirMAP -0.66 0 NA
40 hsa-miR-301a-3p CEP55 -0.76 0.09613 0.99 0.14629 MirTarget -0.58 0 NA
41 hsa-miR-301a-3p CFLAR -0.76 0.09613 -0.19 0.52443 mirMAP -0.2 2.0E-5 NA
42 hsa-miR-301a-3p CHRNA7 -0.76 0.09613 -0.37 0.67746 mirMAP -0.66 0 NA
43 hsa-miR-301a-3p CMPK1 -0.76 0.09613 0.21 0.42634 MirTarget; miRNATAP -0.15 0.00022 NA
44 hsa-miR-301a-3p COL4A4 -0.76 0.09613 -0.35 0.65939 mirMAP -0.42 0.00112 NA
45 hsa-miR-301a-3p CTSK -0.76 0.09613 -0.05 0.94011 MirTarget -0.49 0 NA
46 hsa-miR-301a-3p CYBRD1 -0.76 0.09613 0.13 0.82152 miRNAWalker2 validate -0.35 9.0E-5 NA
47 hsa-miR-301a-3p DCBLD2 -0.76 0.09613 1.11 0.10472 MirTarget; miRNATAP -0.37 0.00096 NA
48 hsa-miR-301a-3p DEPDC1 -0.76 0.09613 0.87 0.19097 MirTarget -0.38 0.00038 NA
49 hsa-miR-301a-3p DIAPH2 -0.76 0.09613 0.37 0.26798 mirMAP -0.37 0 NA
50 hsa-miR-301a-3p DIAPH3 -0.76 0.09613 1.01 0.0985 MirTarget; miRNATAP -0.53 0 NA
51 hsa-miR-301a-3p DSG2 -0.76 0.09613 1.16 0.02127 mirMAP -0.28 0.00054 NA
52 hsa-miR-301a-3p E2F2 -0.76 0.09613 -0.19 0.7383 miRNATAP -0.29 0.00119 NA
53 hsa-miR-301a-3p E2F7 -0.76 0.09613 0.87 0.2158 miRNATAP -0.51 0 NA
54 hsa-miR-301a-3p EDN1 -0.76 0.09613 -0.52 0.36358 MirTarget -0.39 2.0E-5 NA
55 hsa-miR-301a-3p EFNB2 -0.76 0.09613 0.86 0.03481 miRNATAP -0.37 0 NA
56 hsa-miR-301a-3p EIF4EBP2 -0.76 0.09613 -0.05 0.76069 mirMAP -0.18 0 NA
57 hsa-miR-301a-3p ELK3 -0.76 0.09613 -0.28 0.5575 MirTarget; miRNATAP -0.22 0.00519 NA
58 hsa-miR-301a-3p ENDOD1 -0.76 0.09613 0.39 0.28326 MirTarget -0.17 0.00315 NA
59 hsa-miR-301a-3p EPHB4 -0.76 0.09613 0.6 0.15515 miRNATAP -0.41 0 NA
60 hsa-miR-301a-3p EREG -0.76 0.09613 4.41 0.00138 miRNATAP -1.27 0 NA
61 hsa-miR-301a-3p ERLIN2 -0.76 0.09613 0.2 0.43102 mirMAP -0.14 0.00071 NA
62 hsa-miR-301a-3p EXT1 -0.76 0.09613 0.16 0.54187 mirMAP -0.22 0 NA
63 hsa-miR-301a-3p FBXO28 -0.76 0.09613 0.35 0.09605 MirTarget; miRNATAP -0.11 0.00087 NA
64 hsa-miR-301a-3p FGD4 -0.76 0.09613 0.52 0.17379 mirMAP -0.16 0.00759 NA
65 hsa-miR-301a-3p FIBIN -0.76 0.09613 -0.38 0.63537 MirTarget -0.59 0 NA
66 hsa-miR-301a-3p FMN1 -0.76 0.09613 1.42 0.04177 mirMAP -0.52 0 NA
67 hsa-miR-301a-3p FNDC4 -0.76 0.09613 -0.45 0.36303 miRNATAP -0.23 0.0042 NA
68 hsa-miR-301a-3p FOSL1 -0.76 0.09613 2.38 0.00428 MirTarget -0.6 1.0E-5 NA
69 hsa-miR-301a-3p FOXF2 -0.76 0.09613 1.14 0.0316 miRNATAP -0.45 0 NA
70 hsa-miR-301a-3p FOXP1 -0.76 0.09613 -0.02 0.93749 mirMAP -0.18 0 NA
71 hsa-miR-301a-3p FRMD6 -0.76 0.09613 -0.32 0.5949 MirTarget -0.5 0 NA
72 hsa-miR-301a-3p G0S2 -0.76 0.09613 0.15 0.84254 MirTarget -0.37 0.00224 NA
73 hsa-miR-301a-3p GDA -0.76 0.09613 2.64 0.01236 miRNATAP -0.51 0.00299 NA
74 hsa-miR-301a-3p GJA1 -0.76 0.09613 -0.29 0.55396 MirTarget; miRNATAP -0.3 0.00012 NA
75 hsa-miR-301a-3p GPR157 -0.76 0.09613 0.08 0.88757 mirMAP -0.27 0.00223 NA
76 hsa-miR-301a-3p GPRC5A -0.76 0.09613 3.96 0.00162 mirMAP -1.51 0 NA
77 hsa-miR-301a-3p GSPT1 -0.76 0.09613 0.25 0.20157 mirMAP -0.17 0 NA
78 hsa-miR-301a-3p H6PD -0.76 0.09613 -0.58 0.04995 mirMAP -0.23 0 NA
79 hsa-miR-301a-3p HECA -0.76 0.09613 -0.49 0.04604 MirTarget; miRNATAP -0.16 4.0E-5 NA
80 hsa-miR-301a-3p HES2 -0.76 0.09613 0.16 0.86833 mirMAP -0.55 0.00049 NA
81 hsa-miR-301a-3p HOXA3 -0.76 0.09613 1.12 0.05646 miRNATAP -0.52 0 NA
82 hsa-miR-301a-3p HOXA5 -0.76 0.09613 1.18 0.02773 miRNATAP -0.41 0 NA
83 hsa-miR-301a-3p HRH1 -0.76 0.09613 1.23 0.01267 mirMAP -0.47 0 NA
84 hsa-miR-301a-3p IGF1 -0.76 0.09613 -1.41 0.20856 MirTarget -0.51 0.00543 NA
85 hsa-miR-301a-3p IGF2 -0.76 0.09613 0.45 0.58211 mirMAP -0.42 0.00151 NA
86 hsa-miR-301a-3p IGF2BP1 -0.76 0.09613 0.61 0.61732 mirMAP; miRNATAP -0.67 0.00073 NA
87 hsa-miR-301a-3p IGSF3 -0.76 0.09613 0.78 0.14083 MirTarget -0.43 0 NA
88 hsa-miR-301a-3p IL15 -0.76 0.09613 -0.95 0.00887 MirTarget -0.17 0.00339 NA
89 hsa-miR-301a-3p IL17RA -0.76 0.09613 -0.28 0.27875 mirMAP -0.13 0.00101 NA
90 hsa-miR-301a-3p IL17RD -0.76 0.09613 -0.42 0.32296 mirMAP -0.39 0 NA
91 hsa-miR-301a-3p IL1RAP -0.76 0.09613 0.24 0.6772 MirTarget -0.47 0 NA
92 hsa-miR-301a-3p ITGA2 -0.76 0.09613 0.8 0.18125 mirMAP -0.46 0 NA
93 hsa-miR-301a-3p ITPRIPL2 -0.76 0.09613 0.18 0.53284 MirTarget; miRNATAP -0.32 0 NA
94 hsa-miR-301a-3p IYD -0.76 0.09613 3.23 0.01005 mirMAP -1.29 0 NA
95 hsa-miR-301a-3p KCNE3 -0.76 0.09613 1.28 0.07886 mirMAP -0.59 0 NA
96 hsa-miR-301a-3p KDELR2 -0.76 0.09613 0.88 0.00046 miRNAWalker2 validate -0.18 1.0E-5 NA
97 hsa-miR-301a-3p KDSR -0.76 0.09613 0.09 0.62561 mirMAP -0.13 3.0E-5 NA
98 hsa-miR-301a-3p KIAA1211 -0.76 0.09613 1.02 0.07908 MirTarget -0.25 0.00753 NA
99 hsa-miR-301a-3p KIAA1217 -0.76 0.09613 0.15 0.72848 MirTarget -0.52 0 NA
100 hsa-miR-301a-3p KIF18B -0.76 0.09613 0.91 0.15141 mirMAP -0.4 8.0E-5 NA
101 hsa-miR-301a-3p KIF1C -0.76 0.09613 -0.08 0.7809 mirMAP -0.24 0 NA
102 hsa-miR-301a-3p KIF26B -0.76 0.09613 0.51 0.44044 mirMAP -0.55 0 NA
103 hsa-miR-301a-3p KIRREL -0.76 0.09613 -0.45 0.56708 mirMAP -0.35 0.00696 NA
104 hsa-miR-301a-3p KLF3 -0.76 0.09613 0.42 0.13439 miRNATAP -0.29 0 NA
105 hsa-miR-301a-3p KLF4 -0.76 0.09613 0.88 0.08321 miRNATAP -0.26 0.00133 NA
106 hsa-miR-301a-3p KLHL20 -0.76 0.09613 -0.11 0.66181 MirTarget; miRNATAP -0.14 0.00034 NA
107 hsa-miR-301a-3p LDLR -0.76 0.09613 0.91 0.1166 miRNATAP -0.44 0 NA
108 hsa-miR-301a-3p LONRF3 -0.76 0.09613 1.46 0.00559 MirTarget -0.54 0 NA
109 hsa-miR-301a-3p LPP -0.76 0.09613 0.05 0.92861 mirMAP -0.54 0 NA
110 hsa-miR-301a-3p LRRC58 -0.76 0.09613 0.03 0.91685 mirMAP -0.17 0.00022 NA
111 hsa-miR-301a-3p MACC1 -0.76 0.09613 0.54 0.4139 mirMAP -0.56 0 NA
112 hsa-miR-301a-3p MAP4 -0.76 0.09613 -0.25 0.18178 MirTarget -0.16 0 NA
113 hsa-miR-301a-3p MBNL1 -0.76 0.09613 -0.55 0.02896 MirTarget; miRNATAP -0.13 0.00195 NA
114 hsa-miR-301a-3p MBNL3 -0.76 0.09613 -0.26 0.67103 MirTarget; mirMAP; miRNATAP -0.4 8.0E-5 NA
115 hsa-miR-301a-3p MCFD2 -0.76 0.09613 0.22 0.37806 mirMAP -0.13 0.00128 NA
116 hsa-miR-301a-3p MDFIC -0.76 0.09613 -0.75 0.12581 MirTarget; miRNATAP -0.35 1.0E-5 NA
117 hsa-miR-301a-3p MEOX2 -0.76 0.09613 -0.26 0.74062 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.48 0.00016 22373864 miR 301a is a candidate oncogene that targets the homeobox gene Gax in human hepatocellular carcinoma; This study aims to characterize the function of upregulated miR-301a in HCC and show how the downstream growth arrest-specific homeobox Gax is negatively regulated by miR-301a; The expression of miR-301a and Gax was detected using real-time PCR on HCC tissues and adjacent non-tumorous tissues; The luciferase reporter assay was used to assess Gax as a target of miR-301a; The nuclear factor κB NF-κB was measured by western blot after inhibiting miR-301a and enhancing Gax; MiR-301a was significantly upregulated and Gax was downregulated in HCC samples compared with in the matching nontumoral tissues; Inhibiting miR-301a expression caused the upregulation of Gax and repressed NF-κB expression; miR-301a is frequently upregulated in HCC and modulates NF-κB expression by negatively regulating Gax
118 hsa-miR-301a-3p MIPOL1 -0.76 0.09613 0.93 0.01754 mirMAP -0.27 1.0E-5 NA
119 hsa-miR-301a-3p MTAP -0.76 0.09613 -0.36 0.47652 mirMAP -0.26 0.00155 NA
120 hsa-miR-301a-3p MUC15 -0.76 0.09613 -0.74 0.62324 MirTarget -0.63 0.00936 NA
121 hsa-miR-301a-3p MUC20 -0.76 0.09613 0.85 0.28357 mirMAP -0.58 0 NA
122 hsa-miR-301a-3p NAA50 -0.76 0.09613 0.14 0.50217 MirTarget; miRNATAP -0.17 0 NA
123 hsa-miR-301a-3p NFIA -0.76 0.09613 -0.29 0.37644 miRNATAP -0.27 0 NA
124 hsa-miR-301a-3p NFIB -0.76 0.09613 -0.28 0.48253 mirMAP; miRNATAP -0.34 0 NA
125 hsa-miR-301a-3p NLN -0.76 0.09613 0.02 0.96757 mirMAP -0.22 0.00032 NA
126 hsa-miR-301a-3p NOTCH2NL -0.76 0.09613 -0.52 0.32099 mirMAP -0.55 0 NA
127 hsa-miR-301a-3p NOX4 -0.76 0.09613 0.8 0.32066 MirTarget -0.61 0 NA
128 hsa-miR-301a-3p NPTX1 -0.76 0.09613 -0.19 0.83181 miRNATAP -0.61 1.0E-5 NA
129 hsa-miR-301a-3p NRBF2 -0.76 0.09613 -0.1 0.53207 MirTarget; miRNATAP -0.13 0 NA
130 hsa-miR-301a-3p PARD3B -0.76 0.09613 0.01 0.98353 mirMAP -0.48 1.0E-5 NA
131 hsa-miR-301a-3p PAWR -0.76 0.09613 0.1 0.76694 mirMAP -0.23 1.0E-5 NA
132 hsa-miR-301a-3p PDGFRA -0.76 0.09613 -0.09 0.88305 MirTarget; miRNATAP -0.58 0 NA
133 hsa-miR-301a-3p PELI1 -0.76 0.09613 0.09 0.76823 MirTarget; miRNATAP -0.16 0.00151 NA
134 hsa-miR-301a-3p PGM2L1 -0.76 0.09613 0.65 0.12319 MirTarget; miRNATAP -0.29 2.0E-5 NA
135 hsa-miR-301a-3p PHACTR2 -0.76 0.09613 -0.2 0.56161 miRNATAP -0.17 0.00192 NA
136 hsa-miR-301a-3p PHF14 -0.76 0.09613 0.15 0.36284 MirTarget -0.13 0 NA
137 hsa-miR-301a-3p PIK3CB -0.76 0.09613 0.27 0.23582 miRNATAP -0.13 0.00029 NA
138 hsa-miR-301a-3p PKHD1 -0.76 0.09613 -0.13 0.92023 MirTarget -0.82 9.0E-5 NA
139 hsa-miR-301a-3p PLEKHA2 -0.76 0.09613 -0.7 0.02823 mirMAP -0.15 0.00449 NA
140 hsa-miR-301a-3p PLEKHA5 -0.76 0.09613 1.1 0.00209 mirMAP -0.18 0.00209 NA
141 hsa-miR-301a-3p PMEPA1 -0.76 0.09613 0.39 0.51922 MirTarget; miRNATAP -0.45 0 NA
142 hsa-miR-301a-3p POLR1A -0.76 0.09613 0.01 0.97058 mirMAP -0.11 0.00842 NA
143 hsa-miR-301a-3p PPARD -0.76 0.09613 -0.54 0.06122 mirMAP -0.17 0.00036 NA
144 hsa-miR-301a-3p PPARG -0.76 0.09613 1.21 0.08927 MirTarget; miRNATAP -0.61 0 NA
145 hsa-miR-301a-3p PRKG1 -0.76 0.09613 0 0.99515 miRNATAP -0.52 1.0E-5 NA
146 hsa-miR-301a-3p PRR5L -0.76 0.09613 -0.34 0.49786 miRNATAP -0.58 0 NA
147 hsa-miR-301a-3p PTGFRN -0.76 0.09613 0.59 0.16374 miRNATAP -0.51 0 NA
148 hsa-miR-301a-3p PTP4A1 -0.76 0.09613 0.16 0.63317 miRNATAP -0.17 0.00226 NA
149 hsa-miR-301a-3p PTPN14 -0.76 0.09613 0.52 0.29139 miRNATAP -0.51 0 NA
150 hsa-miR-301a-3p PTPRG -0.76 0.09613 0.08 0.84464 MirTarget; miRNATAP -0.23 0.00083 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 TISSUE DEVELOPMENT 48 1518 2.285e-11 1.063e-07
2 NEGATIVE REGULATION OF CELL PROLIFERATION 29 643 1.34e-10 3.117e-07
3 CELL DEVELOPMENT 44 1426 4.049e-10 6.281e-07
4 REGULATION OF CELL PROLIFERATION 45 1496 5.538e-10 6.442e-07
5 SKELETAL SYSTEM DEVELOPMENT 23 455 1.452e-09 1.352e-06
6 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 33 957 6.123e-09 4.748e-06
7 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 48 1805 7.53e-09 5.006e-06
8 VASCULATURE DEVELOPMENT 22 469 1.311e-08 7.623e-06
9 EMBRYO DEVELOPMENT 31 894 1.641e-08 8.486e-06
10 BLOOD VESSEL MORPHOGENESIS 19 364 2.506e-08 1.166e-05
11 CARDIOVASCULAR SYSTEM DEVELOPMENT 28 788 5.232e-08 2.029e-05
12 CIRCULATORY SYSTEM DEVELOPMENT 28 788 5.232e-08 2.029e-05
13 EPITHELIUM DEVELOPMENT 31 945 5.79e-08 2.072e-05
14 REGULATION OF CELL ADHESION 24 629 1.392e-07 4.626e-05
15 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 10 100 1.61e-07 4.996e-05
16 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 36 1275 1.891e-07 5.175e-05
17 ANGIOGENESIS 16 293 1.796e-07 5.175e-05
18 TUBE DEVELOPMENT 22 552 2.281e-07 5.895e-05
19 REGULATION OF CELLULAR COMPONENT MOVEMENT 26 771 4.455e-07 0.0001091
20 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 10 115 6.005e-07 0.0001397
21 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 21 554 9.79e-07 0.0002169
22 CONNECTIVE TISSUE DEVELOPMENT 12 194 1.765e-06 0.0003734
23 TISSUE MORPHOGENESIS 20 533 2.096e-06 0.0004063
24 LOCOMOTION 31 1114 2.024e-06 0.0004063
25 POSITIVE REGULATION OF GENE EXPRESSION 41 1733 2.481e-06 0.000444
26 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 35 1360 2.433e-06 0.000444
27 CHONDROCYTE DEVELOPMENT 5 21 2.774e-06 0.000478
28 RESPONSE TO STEROID HORMONE 19 497 2.908e-06 0.0004833
29 REGULATION OF EPITHELIAL CELL PROLIFERATION 14 285 3.716e-06 0.0005962
30 POSITIVE REGULATION OF OSSIFICATION 8 84 4.151e-06 0.0006438
31 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 7 60 4.297e-06 0.000645
32 RESPONSE TO WOUNDING 20 563 4.772e-06 0.0006938
33 WOUND HEALING 18 470 5.223e-06 0.0007365
34 CARTILAGE DEVELOPMENT 10 147 5.627e-06 0.0007701
35 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 12 218 5.901e-06 0.0007845
36 ORGAN MORPHOGENESIS 25 841 7.062e-06 0.0009128
37 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 9 122 8.64e-06 0.001087
38 EMBRYONIC MORPHOGENESIS 19 539 9.279e-06 0.001136
39 MORPHOGENESIS OF AN EPITHELIUM 16 400 1.035e-05 0.001196
40 RESPONSE TO ORGANIC CYCLIC COMPOUND 26 917 1.054e-05 0.001196
41 DEVELOPMENTAL MATURATION 11 193 1.046e-05 0.001196
42 POSITIVE REGULATION OF CELL COMMUNICATION 36 1532 1.31e-05 0.001452
43 TUBE MORPHOGENESIS 14 323 1.541e-05 0.001668
44 REGULATION OF SMOOTH MUSCLE CELL MIGRATION 6 49 1.6e-05 0.001692
45 TAXIS 17 464 1.703e-05 0.001761
46 NEGATIVE REGULATION OF GENE EXPRESSION 35 1493 1.85e-05 0.001793
47 RESPONSE TO LIPID 25 888 1.777e-05 0.001793
48 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 27 1004 1.812e-05 0.001793
49 POSITIVE REGULATION OF CELL ADHESION 15 376 2.028e-05 0.001926
50 NEGATIVE REGULATION OF CELL COMMUNICATION 30 1192 2.125e-05 0.001977
51 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 35 1517 2.583e-05 0.002348
52 MULTI MULTICELLULAR ORGANISM PROCESS 11 213 2.624e-05 0.002348
53 POSITIVE REGULATION OF CELL PROLIFERATION 23 814 3.713e-05 0.003211
54 PROTEOGLYCAN METABOLIC PROCESS 7 83 3.726e-05 0.003211
55 EPITHELIAL CELL DIFFERENTIATION 17 495 3.854e-05 0.00326
56 REGULATION OF PHOSPHORUS METABOLIC PROCESS 36 1618 4.188e-05 0.003479
57 NEGATIVE REGULATION OF WOUND HEALING 6 58 4.263e-05 0.00348
58 CELLULAR RESPONSE TO LIPID 16 457 5.208e-05 0.003943
59 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 6 60 5.177e-05 0.003943
60 CHONDROCYTE DIFFERENTIATION 6 60 5.177e-05 0.003943
61 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 9 153 5.254e-05 0.003943
62 TISSUE REMODELING 7 87 5.053e-05 0.003943
63 RESPONSE TO ENDOGENOUS STIMULUS 33 1450 5.911e-05 0.004366
64 NEGATIVE REGULATION OF RESPONSE TO WOUNDING 9 156 6.111e-05 0.004443
65 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 16 465 6.39e-05 0.004574
66 HEART DEVELOPMENT 16 466 6.553e-05 0.00462
67 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 32 1395 6.68e-05 0.004639
68 REGULATION OF WOUND HEALING 8 126 8.045e-05 0.005505
69 REGULATION OF DNA BIOSYNTHETIC PROCESS 7 94 8.292e-05 0.005592
70 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 20 689 8.468e-05 0.005629
71 REGULATION OF CELL CELL ADHESION 14 380 9.015e-05 0.005908
72 REGULATION OF EPITHELIAL CELL MIGRATION 9 166 9.862e-05 0.006268
73 NEURON PROJECTION GUIDANCE 10 205 9.834e-05 0.006268
74 REPRODUCTION 30 1297 9.969e-05 0.006268
75 REGULATION OF CELL DIFFERENTIATION 33 1492 0.0001021 0.006335
76 CELL MATURATION 8 131 0.0001057 0.006472
77 MEMORY 7 98 0.000108 0.006525
78 APPENDAGE DEVELOPMENT 9 169 0.0001131 0.00666
79 LIMB DEVELOPMENT 9 169 0.0001131 0.00666
80 RESPONSE TO MECHANICAL STIMULUS 10 210 0.0001199 0.006976
81 NEURON PROJECTION DEVELOPMENT 17 545 0.0001249 0.007172
82 SPROUTING ANGIOGENESIS 5 45 0.0001342 0.007524
83 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 18 602 0.000134 0.007524
84 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 8 138 0.0001518 0.007798
85 POSITIVE REGULATION OF RESPONSE TO STIMULUS 39 1929 0.0001525 0.007798
86 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 35 1656 0.0001503 0.007798
87 CELL MOTILITY 22 835 0.0001516 0.007798
88 POSITIVE REGULATION OF MOLECULAR FUNCTION 37 1791 0.0001505 0.007798
89 RESPONSE TO HORMONE 23 893 0.000149 0.007798
90 LOCALIZATION OF CELL 22 835 0.0001516 0.007798
91 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 7 103 0.0001476 0.007798
92 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 20 724 0.0001645 0.008092
93 NEURON PROJECTION MORPHOGENESIS 14 402 0.0001624 0.008092
94 CELLULAR COMPONENT MORPHOGENESIS 23 900 0.000167 0.008092
95 REGULATION OF HOMOTYPIC CELL CELL ADHESION 12 307 0.0001666 0.008092
96 GLYCOPROTEIN METABOLIC PROCESS 13 353 0.0001614 0.008092
97 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 35 1672 0.0001809 0.008678
98 REPRODUCTIVE SYSTEM DEVELOPMENT 14 408 0.0001892 0.008982
99 RESPONSE TO KETONE 9 182 0.0001978 0.009208
100 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 16 513 0.0001979 0.009208
101 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 25 1036 0.0002088 0.009525
102 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 25 1036 0.0002088 0.009525
103 REGULATION OF RESPONSE TO WOUNDING 14 413 0.0002143 0.009683
104 RESPONSE TO PROGESTERONE 5 50 0.0002226 0.009958
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 GOLGI APPARATUS 37 1445 1.35e-06 0.0007882

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04380_Osteoclast_differentiation 7 128 0.0005583 0.1005
2 hsa04390_Hippo_signaling_pathway 7 154 0.001648 0.1483
3 hsa04350_TGF.beta_signaling_pathway 5 85 0.002522 0.1513
4 hsa04115_p53_signaling_pathway 4 69 0.007162 0.3223
5 hsa04210_Apoptosis 4 89 0.01707 0.5314
6 hsa04540_Gap_junction 4 90 0.01771 0.5314
7 hsa04510_Focal_adhesion 6 200 0.02398 0.5751
8 hsa04144_Endocytosis 6 203 0.02556 0.5751
9 hsa03320_PPAR_signaling_pathway 3 70 0.04245 0.7635
10 hsa00512_Mucin_type_O.Glycan_biosynthesis 2 30 0.04318 0.7635
11 hsa04014_Ras_signaling_pathway 6 236 0.04759 0.7635
12 hsa04110_Cell_cycle 4 128 0.05377 0.7635
13 hsa04360_Axon_guidance 4 130 0.05631 0.7635
14 hsa04512_ECM.receptor_interaction 3 85 0.06806 0.7635
15 hsa04012_ErbB_signaling_pathway 3 87 0.07191 0.7635
16 hsa04914_Progesterone.mediated_oocyte_maturation 3 87 0.07191 0.7635
17 hsa00600_Sphingolipid_metabolism 2 40 0.0721 0.7635
18 hsa04960_Aldosterone.regulated_sodium_reabsorption 2 42 0.07847 0.7847
19 hsa04310_Wnt_signaling_pathway 4 151 0.08672 0.8037
20 hsa04810_Regulation_of_actin_cytoskeleton 5 214 0.0893 0.8037
21 hsa04150_mTOR_signaling_pathway 2 52 0.1127 0.9656
22 hsa04020_Calcium_signaling_pathway 4 177 0.1331 1
23 hsa04610_Complement_and_coagulation_cascades 2 69 0.1771 1
24 hsa04730_Long.term_depression 2 70 0.1811 1
25 hsa04520_Adherens_junction 2 73 0.1931 1
26 hsa04151_PI3K_AKT_signaling_pathway 6 351 0.1937 1
27 hsa04370_VEGF_signaling_pathway 2 76 0.2051 1
28 hsa04974_Protein_digestion_and_absorption 2 81 0.2254 1
29 hsa04630_Jak.STAT_signaling_pathway 3 155 0.2454 1
30 hsa00240_Pyrimidine_metabolism 2 99 0.299 1
31 hsa04620_Toll.like_receptor_signaling_pathway 2 102 0.3112 1
32 hsa04114_Oocyte_meiosis 2 114 0.3596 1
33 hsa04722_Neurotrophin_signaling_pathway 2 127 0.4105 1
34 hsa00230_Purine_metabolism 2 162 0.5365 1
35 hsa04010_MAPK_signaling_pathway 3 268 0.5708 1

Quest ID: 6b3cffbab445e4f6c546092b7285de9b