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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-106b-5p AKT3 2.81 0 -3.33 1.0E-5 miRNATAP -0.41 1.0E-5 NA
2 hsa-miR-142-3p AKT3 4.35 0 -3.33 1.0E-5 miRanda -0.16 0.00934 NA
3 hsa-miR-15a-5p AKT3 2.05 0 -3.33 1.0E-5 miRNAWalker2 validate; miRTarBase; miRNATAP -0.37 0.00021 NA
4 hsa-miR-15b-5p AKT3 3.32 0 -3.33 1.0E-5 miRNATAP -0.25 0.00571 NA
5 hsa-miR-16-5p AKT3 2.94 0 -3.33 1.0E-5 miRNAWalker2 validate; miRTarBase; miRNATAP -0.31 0.00086 NA
6 hsa-miR-29b-3p AKT3 0.67 0.23406 -3.33 1.0E-5 miRNATAP -0.28 0.00031 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
7 hsa-miR-3065-5p AKT3 2.14 0.06094 -3.33 1.0E-5 mirMAP -0.22 0 NA
8 hsa-miR-362-3p AKT3 0.68 0.22615 -3.33 1.0E-5 miRanda -0.25 0.00124 NA
9 hsa-miR-501-3p AKT3 1.72 0.00759 -3.33 1.0E-5 miRNATAP -0.18 0.00733 NA
10 hsa-miR-93-5p AKT3 2.66 0 -3.33 1.0E-5 miRNATAP -0.33 0.00021 NA
11 hsa-miR-342-3p BCL2L1 1.31 0.02072 0.39 0.37256 PITA; miRanda; miRNATAP -0.13 0.00344 NA
12 hsa-let-7d-5p CBL 0.83 0.0127 -0.22 0.60145 MirTarget -0.21 0.0047 NA
13 hsa-miR-141-5p CBL 7.14 0 -0.22 0.60145 mirMAP -0.12 0.0004 NA
14 hsa-miR-200c-3p CBL 6.47 0 -0.22 0.60145 MirTarget; mirMAP -0.1 0.00481 NA
15 hsa-miR-29c-3p CBL -0.41 0.52934 -0.22 0.60145 mirMAP -0.12 0.00078 NA
16 hsa-miR-30e-3p CBL -0.04 0.93258 -0.22 0.60145 MirTarget -0.22 0.00015 NA
17 hsa-miR-374a-3p CBL 0.47 0.30527 -0.22 0.60145 mirMAP -0.18 0.00096 NA
18 hsa-miR-3913-5p CBL 0.15 0.73484 -0.22 0.60145 MirTarget; miRNATAP -0.17 0.00253 NA
19 hsa-miR-222-5p CBLB 2.52 0.00142 -0.06 0.89329 MirTarget -0.1 0.00159 NA
20 hsa-let-7a-5p CCND1 0.15 0.64531 0.15 0.87753 TargetScan; miRNATAP -0.54 0.00245 NA
21 hsa-miR-106a-5p CCND1 3.99 0 0.15 0.87753 MirTarget; miRNATAP -0.43 0 NA
22 hsa-miR-15a-5p CCND1 2.05 0 0.15 0.87753 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.35 0.00776 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR
23 hsa-miR-15b-5p CCND1 3.32 0 0.15 0.87753 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.42 0.00029 NA
24 hsa-miR-20b-5p CCND1 4.57 5.0E-5 0.15 0.87753 MirTarget; miRNATAP -0.31 0 NA
25 hsa-miR-34a-5p CCND1 0.83 0.04775 0.15 0.87753 miRNAWalker2 validate; miRTarBase; miRNATAP -0.42 0.00174 25792709; 21399894 This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a
26 hsa-miR-497-5p CCND1 -1.44 0.02251 0.15 0.87753 MirTarget; miRNATAP -0.25 0.00498 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer
27 hsa-miR-106a-5p CCND2 3.99 0 -2.81 0.0014 miRNATAP -0.44 0 NA
28 hsa-miR-106b-5p CCND2 2.81 0 -2.81 0.0014 miRNAWalker2 validate; miRTarBase; miRNATAP -0.31 0.00374 NA
29 hsa-miR-10a-3p CCND2 0.97 0.31667 -2.81 0.0014 mirMAP -0.2 0.00011 NA
30 hsa-miR-130b-5p CCND2 3.74 0 -2.81 0.0014 mirMAP -0.46 0 NA
31 hsa-miR-141-3p CCND2 7.3 0 -2.81 0.0014 MirTarget; TargetScan -0.24 0.00021 NA
32 hsa-miR-15b-5p CCND2 3.32 0 -2.81 0.0014 miRNATAP -0.53 0 NA
33 hsa-miR-16-2-3p CCND2 3.8 0 -2.81 0.0014 mirMAP -0.29 0.00207 NA
34 hsa-miR-182-5p CCND2 5.87 0 -2.81 0.0014 miRNAWalker2 validate; miRTarBase; miRNATAP -0.28 2.0E-5 NA
35 hsa-miR-183-5p CCND2 6.62 0 -2.81 0.0014 miRNATAP -0.29 0 NA
36 hsa-miR-191-5p CCND2 1.59 0.00074 -2.81 0.0014 MirTarget -0.32 0.00314 NA
37 hsa-miR-200a-3p CCND2 6.34 0 -2.81 0.0014 MirTarget -0.41 0 NA
38 hsa-miR-20b-5p CCND2 4.57 5.0E-5 -2.81 0.0014 miRNATAP -0.3 0 NA
39 hsa-miR-224-3p CCND2 2.85 0.00018 -2.81 0.0014 mirMAP -0.22 0.00101 NA
40 hsa-miR-28-5p CCND2 -0.82 0.02212 -2.81 0.0014 miRanda -0.43 0.00273 NA
41 hsa-miR-3065-3p CCND2 1.89 0.03082 -2.81 0.0014 MirTarget; miRNATAP -0.21 0.00027 NA
42 hsa-miR-3065-5p CCND2 2.14 0.06094 -2.81 0.0014 mirMAP -0.2 0.00026 NA
43 hsa-miR-30d-3p CCND2 -0.07 0.85742 -2.81 0.0014 mirMAP -0.55 1.0E-5 NA
44 hsa-miR-324-3p CCND2 1.51 0.00384 -2.81 0.0014 miRNAWalker2 validate -0.44 0 NA
45 hsa-miR-33a-3p CCND2 2.06 0.00156 -2.81 0.0014 MirTarget -0.27 0.00041 NA
46 hsa-miR-378a-3p CCND2 1.47 0.04667 -2.81 0.0014 miRNAWalker2 validate -0.19 0.00601 NA
47 hsa-miR-429 CCND2 6.4 0 -2.81 0.0014 miRNATAP -0.46 0 NA
48 hsa-miR-497-5p CCND2 -1.44 0.02251 -2.81 0.0014 MirTarget; miRNATAP -0.27 0.00058 NA
49 hsa-miR-550a-5p CCND2 1.22 0.06138 -2.81 0.0014 MirTarget -0.22 0.00363 NA
50 hsa-miR-660-5p CCND2 -0.07 0.88525 -2.81 0.0014 mirMAP -0.29 0.00793 NA
51 hsa-miR-9-3p CCND2 1.69 0.12517 -2.81 0.0014 MirTarget; mirMAP; miRNATAP -0.14 0.00185 NA
52 hsa-miR-93-5p CCND2 2.66 0 -2.81 0.0014 miRNATAP -0.48 0 NA
53 hsa-miR-96-5p CCND2 5.63 0 -2.81 0.0014 TargetScan; miRNATAP -0.24 0.0003 NA
54 hsa-miR-27b-3p CCND3 -0.09 0.85847 -0.54 0.12437 miRNAWalker2 validate -0.14 0.00019 NA
55 hsa-miR-429 CCND3 6.4 0 -0.54 0.12437 miRNATAP -0.11 1.0E-5 NA
56 hsa-miR-96-5p CCND3 5.63 0 -0.54 0.12437 TargetScan -0.12 1.0E-5 NA
57 hsa-miR-24-3p CISH 1.56 0.00052 -0.89 0.10733 MirTarget -0.25 0.00041 NA
58 hsa-miR-324-5p CISH 1.31 0.01168 -0.89 0.10733 miRanda -0.2 0.0012 NA
59 hsa-miR-200b-3p CNTFR 5.56 0 -4.16 0.0243 TargetScan -0.44 0.00218 NA
60 hsa-miR-200c-3p CNTFR 6.47 0 -4.16 0.0243 miRNATAP -0.62 9.0E-5 NA
61 hsa-miR-21-5p CNTFR 2.65 0 -4.16 0.0243 miRNATAP -0.95 0.00229 NA
62 hsa-miR-429 CNTFR 6.4 0 -4.16 0.0243 PITA; miRanda; miRNATAP -0.37 0.00625 NA
63 hsa-miR-589-5p CNTFR 1.56 0.00033 -4.16 0.0243 miRNATAP -0.63 0.00999 NA
64 hsa-miR-21-3p CREBBP 3.5 0 -0.4 0.18067 MirTarget -0.14 0 NA
65 hsa-miR-590-3p CREBBP 2.35 0 -0.4 0.18067 PITA; miRanda; mirMAP; miRNATAP -0.1 0.00219 NA
66 hsa-miR-217 CSF2RA -0.38 0.71741 1.05 0.28308 miRanda -0.23 1.0E-5 NA
67 hsa-miR-429 CSF2RA 6.4 0 1.05 0.28308 miRanda -0.22 0.00182 NA
68 hsa-miR-15b-3p CSF2RB 3.58 0 -0.53 0.5247 mirMAP -0.24 0.00379 NA
69 hsa-miR-19b-3p CSF2RB 1.68 0.00086 -0.53 0.5247 MirTarget -0.25 0.00793 NA
70 hsa-miR-30b-3p CSF2RB 0.17 0.76608 -0.53 0.5247 MirTarget -0.28 0.00087 NA
71 hsa-miR-30b-3p CSF3R 0.17 0.76608 0.32 0.72354 MirTarget -0.25 0.00528 NA
72 hsa-miR-361-5p CSF3R 0.01 0.9852 0.32 0.72354 miRanda -0.61 3.0E-5 NA
73 hsa-miR-429 CSF3R 6.4 0 0.32 0.72354 miRanda -0.2 0.00181 NA
74 hsa-miR-185-5p CTF1 2.47 0 -2.6 0.00053 MirTarget -0.41 1.0E-5 NA
75 hsa-miR-342-3p CTF1 1.31 0.02072 -2.6 0.00053 miRanda -0.23 0.00232 NA
76 hsa-miR-148a-3p EP300 1.1 0.05204 0.22 0.57893 miRNATAP -0.1 0.00975 NA
77 hsa-miR-30c-5p EP300 0.39 0.34861 0.22 0.57893 miRNAWalker2 validate -0.19 0.0009 NA
78 hsa-miR-339-5p EP300 1.23 0.03075 0.22 0.57893 miRanda -0.2 0 NA
79 hsa-miR-342-3p EP300 1.31 0.02072 0.22 0.57893 MirTarget; PITA; miRanda; miRNATAP -0.12 0.00407 NA
80 hsa-miR-374b-5p EP300 -0.11 0.76489 0.22 0.57893 mirMAP; miRNATAP -0.16 0.00856 NA
81 hsa-miR-590-3p EP300 2.35 0 0.22 0.57893 MirTarget; PITA; miRanda; mirMAP; miRNATAP -0.14 0.00229 NA
82 hsa-miR-15a-5p GHR 2.05 0 -3.3 0.01335 MirTarget; miRNATAP -0.68 9.0E-5 NA
83 hsa-miR-15b-5p GHR 3.32 0 -3.3 0.01335 MirTarget; miRNATAP -0.52 0.00106 NA
84 hsa-miR-16-2-3p GHR 3.8 0 -3.3 0.01335 mirMAP -0.5 0.00041 NA
85 hsa-miR-16-5p GHR 2.94 0 -3.3 0.01335 MirTarget; miRNATAP -0.56 0.00046 NA
86 hsa-miR-3065-5p GHR 2.14 0.06094 -3.3 0.01335 MirTarget -0.38 0 NA
87 hsa-miR-338-5p GHR -0.11 0.89468 -3.3 0.01335 PITA -0.5 0 NA
88 hsa-miR-7-1-3p GHR 1.43 0.00471 -3.3 0.01335 MirTarget; mirMAP -0.41 0.00648 NA
89 hsa-miR-1271-5p IFNAR2 0.21 0.74254 -0.05 0.87658 mirMAP -0.13 2.0E-5 NA
90 hsa-miR-508-3p IFNE 0.98 0.43953 4.56 0.00032 MirTarget -0.17 0.00391 NA
91 hsa-miR-125a-5p IFNG -1.32 0.00714 3.94 0.0051 miRanda -0.64 9.0E-5 NA
92 hsa-miR-369-3p IFNG 0.37 0.63876 3.94 0.0051 PITA; miRNATAP -0.31 0.00283 NA
93 hsa-miR-409-3p IFNG 0.29 0.67815 3.94 0.0051 miRNAWalker2 validate -0.43 0.00012 NA
94 hsa-miR-429 IFNG 6.4 0 3.94 0.0051 miRanda -0.3 0.00378 NA
95 hsa-miR-362-3p IFNGR1 0.68 0.22615 0.12 0.78871 miRanda -0.12 0.00701 NA
96 hsa-miR-429 IFNGR1 6.4 0 0.12 0.78871 miRNATAP -0.13 3.0E-5 NA
97 hsa-miR-375 IFNK 3.38 0.04499 1.68 0.22278 miRanda -0.18 0.0001 NA
98 hsa-miR-106a-5p IL10 3.99 0 2.55 0.00205 miRNAWalker2 validate -0.17 0.00228 NA
99 hsa-miR-361-5p IL10 0.01 0.9852 2.55 0.00205 MirTarget; PITA; miRanda; miRNATAP -0.37 0.0076 NA
100 hsa-miR-3607-3p IL11 1.38 0.02401 2.82 0.01391 MirTarget -0.37 0.00053 NA
101 hsa-miR-330-5p IL11RA 2.25 0.00028 -2.49 1.0E-5 miRanda -0.23 1.0E-5 NA
102 hsa-miR-217 IL12RB1 -0.38 0.71741 1.63 0.096 miRanda -0.15 0.00464 NA
103 hsa-miR-125a-5p IL12RB2 -1.32 0.00714 4.35 0.00344 miRanda -1.12 0 NA
104 hsa-miR-129-5p IL12RB2 -2.67 0.00696 4.35 0.00344 miRanda -0.32 0.00017 NA
105 hsa-miR-28-5p IL12RB2 -0.82 0.02212 4.35 0.00344 miRanda -0.87 0.0003 NA
106 hsa-miR-338-3p IL12RB2 0.45 0.55849 4.35 0.00344 miRanda -0.61 0 NA
107 hsa-miR-16-2-3p IL13RA1 3.8 0 0.06 0.87403 MirTarget -0.11 0.00849 NA
108 hsa-miR-378a-5p IL13RA1 1.26 0.05009 0.06 0.87403 MirTarget -0.12 0.00077 NA
109 hsa-miR-129-5p IL15 -2.67 0.00696 0.47 0.59811 miRanda -0.28 0 NA
110 hsa-miR-130b-3p IL15 3.92 0 0.47 0.59811 MirTarget -0.47 0 NA
111 hsa-miR-301a-3p IL15 1.99 0.00081 0.47 0.59811 MirTarget -0.26 0.00197 NA
112 hsa-miR-324-5p IL15 1.31 0.01168 0.47 0.59811 miRanda -0.33 0.00067 NA
113 hsa-miR-421 IL15 1.98 0.00092 0.47 0.59811 miRanda -0.28 0.0009 NA
114 hsa-miR-429 IL15 6.4 0 0.47 0.59811 miRanda -0.25 8.0E-5 NA
115 hsa-miR-493-5p IL15 0.17 0.8342 0.47 0.59811 MirTarget -0.21 0.00066 NA
116 hsa-miR-125a-5p IL15RA -1.32 0.00714 -0.81 0.2072 miRanda -0.2 0.00633 NA
117 hsa-miR-199a-5p IL15RA -1.25 0.07478 -0.81 0.2072 miRanda -0.21 6.0E-5 NA
118 hsa-miR-28-5p IL15RA -0.82 0.02212 -0.81 0.2072 miRanda -0.28 0.00692 NA
119 hsa-miR-335-3p IL19 1.2 0.09389 0.99 0.52932 MirTarget -0.37 0.00336 NA
120 hsa-miR-125a-3p IL20RB -0.07 0.92074 5.71 0.00123 miRanda -0.44 0.00104 NA
121 hsa-miR-28-5p IL20RB -0.82 0.02212 5.71 0.00123 miRanda -1.39 0 NA
122 hsa-miR-199a-5p IL21R -1.25 0.07478 2.85 0.00444 miRanda -0.26 0.00148 NA
123 hsa-miR-335-5p IL21R 0.17 0.8039 2.85 0.00444 miRNAWalker2 validate -0.27 0.00159 NA
124 hsa-miR-125a-5p IL22RA1 -1.32 0.00714 3.48 7.0E-5 miRanda -0.37 0.00027 NA
125 hsa-miR-129-5p IL22RA2 -2.67 0.00696 3.13 0.02231 miRanda -0.3 0.00017 NA
126 hsa-miR-361-5p IL24 0.01 0.9852 2.5 0.11156 miRanda -0.76 0.00361 NA
127 hsa-miR-429 IL24 6.4 0 2.5 0.11156 miRanda -0.31 0.00666 NA
128 hsa-miR-199a-5p IL2RA -1.25 0.07478 2.6 0.00695 miRanda -0.28 0.00032 NA
129 hsa-miR-3065-3p IL2RA 1.89 0.03082 2.6 0.00695 MirTarget -0.21 0.00066 NA
130 hsa-miR-375 IL2RA 3.38 0.04499 2.6 0.00695 miRanda -0.18 0 NA
131 hsa-miR-500a-3p IL2RA 0.52 0.33508 2.6 0.00695 MirTarget -0.31 0.0027 NA
132 hsa-miR-145-5p IL2RB -3.56 0 1.38 0.10349 mirMAP -0.22 0.00084 NA
133 hsa-miR-299-5p IL2RB -1.26 0.10353 1.38 0.10349 mirMAP -0.18 0.00368 NA
134 hsa-miR-331-3p IL4R 2.61 0 0.37 0.54345 miRNAWalker2 validate -0.18 0.00755 NA
135 hsa-miR-429 IL4R 6.4 0 0.37 0.54345 miRNATAP -0.21 0 NA
136 hsa-miR-491-5p IL4R 0.57 0.31331 0.37 0.54345 miRanda -0.19 0.00182 NA
137 hsa-miR-429 IL6 6.4 0 -0.81 0.55699 miRanda -0.5 0 NA
138 hsa-miR-130a-5p IL6R 1.58 0.02435 -1.32 0.11928 MirTarget; miRNATAP -0.2 0.00453 NA
139 hsa-miR-141-3p IL6R 7.3 0 -1.32 0.11928 MirTarget -0.18 0.00323 NA
140 hsa-miR-182-5p IL6R 5.87 0 -1.32 0.11928 mirMAP -0.18 0.00348 NA
141 hsa-miR-200a-3p IL6R 6.34 0 -1.32 0.11928 MirTarget -0.19 0.00116 NA
142 hsa-let-7a-3p IL6ST 0.83 0.04681 -0.27 0.81784 mirMAP -0.52 0.00103 NA
143 hsa-miR-1301-3p IL6ST 2.03 0.00096 -0.27 0.81784 MirTarget -0.37 0.00053 NA
144 hsa-miR-148b-5p IL6ST 2.81 0 -0.27 0.81784 mirMAP -0.4 0.0015 NA
145 hsa-miR-182-5p IL6ST 5.87 0 -0.27 0.81784 mirMAP -0.31 0.00021 NA
146 hsa-miR-24-1-5p IL6ST -0.64 0.23613 -0.27 0.81784 MirTarget -0.36 0.00278 NA
147 hsa-miR-26b-5p IL6ST 0.31 0.46163 -0.27 0.81784 mirMAP -0.41 0.00882 NA
148 hsa-miR-28-3p IL6ST -0.99 0.01882 -0.27 0.81784 mirMAP -0.48 0.00217 NA
149 hsa-miR-29b-2-5p IL6ST -0.6 0.18954 -0.27 0.81784 mirMAP -0.43 0.00338 NA
150 hsa-miR-30b-5p IL6ST 0.02 0.95322 -0.27 0.81784 mirMAP -0.48 0.00352 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CYTOKINE MEDIATED SIGNALING PATHWAY 46 452 4.616e-53 2.148e-49
2 RESPONSE TO CYTOKINE 50 714 5.114e-50 1.19e-46
3 CELLULAR RESPONSE TO CYTOKINE STIMULUS 47 606 1.113e-48 1.727e-45
4 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 63 1848 1.473e-46 1.714e-43
5 REGULATION OF JAK STAT CASCADE 24 144 4.345e-32 3.369e-29
6 REGULATION OF STAT CASCADE 24 144 4.345e-32 3.369e-29
7 STAT CASCADE 16 50 1.366e-26 7.946e-24
8 JAK STAT CASCADE 16 50 1.366e-26 7.946e-24
9 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 45 1656 2.443e-26 1.263e-23
10 POSITIVE REGULATION OF STAT CASCADE 16 73 1.356e-23 5.734e-21
11 POSITIVE REGULATION OF JAK STAT CASCADE 16 73 1.356e-23 5.734e-21
12 REGULATION OF PHOSPHORUS METABOLIC PROCESS 41 1618 1.719e-22 6.664e-20
13 POSITIVE REGULATION OF RESPONSE TO STIMULUS 43 1929 1.421e-21 5.085e-19
14 REGULATION OF TYROSINE PHOSPHORYLATION OF STAT3 PROTEIN 13 44 3.103e-21 1.031e-18
15 REGULATION OF PROTEIN MODIFICATION PROCESS 40 1710 1.34e-20 4.158e-18
16 REGULATION OF TYROSINE PHOSPHORYLATION OF STAT PROTEIN 14 68 2.492e-20 7.247e-18
17 POSITIVE REGULATION OF TYROSINE PHOSPHORYLATION OF STAT3 PROTEIN 12 37 3.051e-20 8.35e-18
18 IMMUNE SYSTEM PROCESS 42 1984 3.86e-20 9.979e-18
19 INTRACELLULAR SIGNAL TRANSDUCTION 38 1572 6.242e-20 1.529e-17
20 REGULATION OF IMMUNE RESPONSE 30 858 7.467e-20 1.737e-17
21 CELL ACTIVATION 25 568 7.817e-19 1.732e-16
22 LYMPHOCYTE ACTIVATION 21 342 8.881e-19 1.878e-16
23 REGULATION OF IMMUNE SYSTEM PROCESS 35 1403 1.233e-18 2.495e-16
24 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 29 876 1.592e-18 3.086e-16
25 REGULATION OF KINASE ACTIVITY 27 776 9.311e-18 1.733e-15
26 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 17 213 3.192e-17 5.712e-15
27 LEUKOCYTE ACTIVATION 21 414 4.369e-17 7.529e-15
28 REGULATION OF CELL PROLIFERATION 34 1496 7.992e-17 1.328e-14
29 LYMPHOCYTE DIFFERENTIATION 16 209 5.758e-16 9.238e-14
30 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 33 1492 6.019e-16 9.336e-14
31 REGULATION OF DEFENSE RESPONSE 25 759 7.059e-16 1.059e-13
32 REGULATION OF HOMOTYPIC CELL CELL ADHESION 18 307 8.101e-16 1.178e-13
33 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 28 1036 1.321e-15 1.756e-13
34 REGULATION OF TRANSFERASE ACTIVITY 27 946 1.286e-15 1.756e-13
35 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 28 1036 1.321e-15 1.756e-13
36 PHOSPHORYLATION 30 1228 1.427e-15 1.845e-13
37 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 29 1135 1.534e-15 1.929e-13
38 REGULATION OF CELL CELL ADHESION 19 380 2.162e-15 2.647e-13
39 POSITIVE REGULATION OF CELL PROLIFERATION 25 814 3.528e-15 4.209e-13
40 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 14 162 8.122e-15 9.448e-13
41 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 23 689 9.685e-15 1.099e-12
42 CELLULAR RESPONSE TO GROWTH HORMONE STIMULUS 8 20 1.011e-14 1.12e-12
43 PROTEIN PHOSPHORYLATION 26 944 1.144e-14 1.238e-12
44 REGULATION OF CELL ACTIVATION 20 484 1.346e-14 1.423e-12
45 REGULATION OF CELL ADHESION 22 629 1.592e-14 1.646e-12
46 NEGATIVE REGULATION OF CELL DEATH 25 872 1.694e-14 1.713e-12
47 POSITIVE REGULATION OF CELL ACTIVATION 17 311 1.777e-14 1.759e-12
48 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 30 1360 2.161e-14 2.095e-12
49 RESPONSE TO HORMONE 25 893 2.904e-14 2.757e-12
50 POSITIVE REGULATION OF CELL COMMUNICATION 31 1532 7.079e-14 6.588e-12
51 LEUKOCYTE DIFFERENTIATION 16 292 1.092e-13 9.959e-12
52 RESPONSE TO NITROGEN COMPOUND 24 859 1.117e-13 9.994e-12
53 RESPONSE TO ENDOGENOUS STIMULUS 30 1450 1.161e-13 1.02e-11
54 POSITIVE REGULATION OF CELL CELL ADHESION 15 243 1.219e-13 1.05e-11
55 REGULATION OF RESPONSE TO STRESS 30 1468 1.602e-13 1.355e-11
56 REGULATION OF CELL DEATH 30 1472 1.72e-13 1.429e-11
57 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 23 799 2.182e-13 1.782e-11
58 LEUKOCYTE CELL CELL ADHESION 15 255 2.464e-13 1.977e-11
59 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 19 498 2.804e-13 2.211e-11
60 POSITIVE REGULATION OF CYTOKINE PRODUCTION 17 370 3.011e-13 2.335e-11
61 REGULATION OF HEMOPOIESIS 16 314 3.341e-13 2.548e-11
62 NEGATIVE REGULATION OF CELL COMMUNICATION 27 1192 3.419e-13 2.566e-11
63 IMMUNE RESPONSE 26 1100 3.996e-13 2.951e-11
64 RESPONSE TO GROWTH HORMONE 8 30 4.538e-13 3.299e-11
65 REGULATION OF T CELL DIFFERENTIATION 11 107 1.064e-12 7.616e-11
66 REGULATION OF LEUKOCYTE DIFFERENTIATION 14 232 1.168e-12 8.221e-11
67 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 23 867 1.184e-12 8.221e-11
68 RESPONSE TO PEPTIDE 17 404 1.238e-12 8.348e-11
69 PEPTIDYL TYROSINE MODIFICATION 13 186 1.229e-12 8.348e-11
70 POSITIVE REGULATION OF LYMPHOCYTE DIFFERENTIATION 10 80 1.625e-12 1.08e-10
71 CELLULAR RESPONSE TO HORMONE STIMULUS 19 552 1.721e-12 1.128e-10
72 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 28 1395 2.08e-12 1.344e-10
73 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 24 1008 3.43e-12 2.186e-10
74 POSITIVE REGULATION OF HEMOPOIESIS 12 163 5.184e-12 3.139e-10
75 DEFENSE RESPONSE 26 1231 5.159e-12 3.139e-10
76 LEUKOCYTE MIGRATION 14 259 5.195e-12 3.139e-10
77 POSITIVE REGULATION OF CELL ADHESION 16 376 5.179e-12 3.139e-10
78 CELL PROLIFERATION 20 672 5.823e-12 3.474e-10
79 POSITIVE REGULATION OF LEUKOCYTE DIFFERENTIATION 11 131 1.003e-11 5.906e-10
80 RESPONSE TO OXYGEN CONTAINING COMPOUND 27 1381 1.07e-11 6.226e-10
81 REGULATION OF LYMPHOCYTE DIFFERENTIATION 11 132 1.09e-11 6.262e-10
82 REGULATION OF CYTOKINE PRODUCTION 18 563 2.431e-11 1.38e-09
83 JAK STAT CASCADE INVOLVED IN GROWTH HORMONE SIGNALING PATHWAY 6 15 2.569e-11 1.44e-09
84 REGULATION OF INFLAMMATORY RESPONSE 14 294 2.841e-11 1.574e-09
85 REGULATION OF T CELL PROLIFERATION 11 147 3.537e-11 1.936e-09
86 IMMUNE SYSTEM DEVELOPMENT 18 582 4.188e-11 2.266e-09
87 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 16 437 4.9e-11 2.62e-09
88 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 31 1977 5.664e-11 2.995e-09
89 REGULATION OF CELL DIFFERENTIATION 27 1492 6.278e-11 3.282e-09
90 REGULATION OF LEUKOCYTE PROLIFERATION 12 206 8.109e-11 4.192e-09
91 SINGLE ORGANISM CELL ADHESION 16 459 1.012e-10 5.176e-09
92 T CELL DIFFERENTIATION 10 123 1.275e-10 6.45e-09
93 RESPONSE TO ORGANIC CYCLIC COMPOUND 21 917 2.085e-10 1.043e-08
94 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 23 1142 3.014e-10 1.492e-08
95 NEGATIVE REGULATION OF PHOSPHORYLATION 15 422 3.174e-10 1.555e-08
96 REGULATION OF INNATE IMMUNE RESPONSE 14 357 3.675e-10 1.781e-08
97 REGULATION OF RESPONSE TO INTERFERON GAMMA 6 22 3.738e-10 1.793e-08
98 CELLULAR RESPONSE TO NITROGEN COMPOUND 16 505 4.097e-10 1.945e-08
99 REGULATION OF RESPONSE TO CYTOKINE STIMULUS 10 144 6.066e-10 2.851e-08
100 CELL CELL ADHESION 17 608 7.348e-10 3.385e-08
101 POSITIVE REGULATION OF MOLECULAR FUNCTION 28 1791 7.314e-10 3.385e-08
102 RESPONSE TO EXTERNAL STIMULUS 28 1821 1.067e-09 4.865e-08
103 REGULATION OF GROWTH 17 633 1.353e-09 6.112e-08
104 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 7 49 1.573e-09 7.038e-08
105 POSITIVE REGULATION OF IMMUNE RESPONSE 16 563 1.968e-09 8.722e-08
106 CELLULAR RESPONSE TO PEPTIDE 12 274 2.136e-09 9.376e-08
107 IMMUNE EFFECTOR PROCESS 15 486 2.198e-09 9.557e-08
108 PEPTIDYL AMINO ACID MODIFICATION 19 841 2.218e-09 9.557e-08
109 REGULATION OF RESPONSE TO WOUNDING 14 413 2.42e-09 1.033e-07
110 REGULATION OF MAPK CASCADE 17 660 2.537e-09 1.073e-07
111 REGULATION OF ADAPTIVE IMMUNE RESPONSE 9 123 2.891e-09 1.212e-07
112 REGULATION OF IMMUNE EFFECTOR PROCESS 14 424 3.387e-09 1.407e-07
113 NATURAL KILLER CELL ACTIVATION 7 55 3.64e-09 1.499e-07
114 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 26 1672 4.067e-09 1.634e-07
115 HOMEOSTASIS OF NUMBER OF CELLS 10 175 4.055e-09 1.634e-07
116 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 8 88 4.074e-09 1.634e-07
117 RESPONSE TO ALCOHOL 13 362 4.776e-09 1.899e-07
118 RESPONSE TO BIOTIC STIMULUS 19 886 5.203e-09 2.052e-07
119 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 7 59 6.035e-09 2.36e-07
120 POSITIVE REGULATION OF LEUKOCYTE PROLIFERATION 9 136 7.029e-09 2.726e-07
121 POSITIVE REGULATION OF T CELL PROLIFERATION 8 95 7.519e-09 2.891e-07
122 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 15 541 9.313e-09 3.523e-07
123 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 15 541 9.313e-09 3.523e-07
124 REGULATION OF CELL KILLING 7 63 9.653e-09 3.622e-07
125 NEGATIVE REGULATION OF KINASE ACTIVITY 11 250 1.001e-08 3.725e-07
126 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 14 470 1.251e-08 4.619e-07
127 CELL MOTILITY 18 835 1.303e-08 4.735e-07
128 LOCALIZATION OF CELL 18 835 1.303e-08 4.735e-07
129 POSITIVE REGULATION OF CATALYTIC ACTIVITY 24 1518 1.399e-08 5.046e-07
130 POSITIVE REGULATION OF KINASE ACTIVITY 14 482 1.717e-08 6.147e-07
131 REGULATION OF LEUKOCYTE MEDIATED IMMUNITY 9 156 2.335e-08 8.294e-07
132 REGULATION OF LYMPHOCYTE MEDIATED IMMUNITY 8 114 3.187e-08 1.123e-06
133 NEGATIVE REGULATION OF ERBB SIGNALING PATHWAY 6 44 3.279e-08 1.13e-06
134 NEGATIVE REGULATION OF JAK STAT CASCADE 6 44 3.279e-08 1.13e-06
135 NEGATIVE REGULATION OF STAT CASCADE 6 44 3.279e-08 1.13e-06
136 RESPONSE TO ESTROGEN 10 218 3.312e-08 1.133e-06
137 RESPONSE TO LIPID 18 888 3.342e-08 1.135e-06
138 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 8 118 4.178e-08 1.409e-06
139 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 8 120 4.765e-08 1.595e-06
140 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 15 616 5.183e-08 1.723e-06
141 POSITIVE REGULATION OF CELL DIFFERENTIATION 17 823 6.525e-08 2.135e-06
142 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 25 6.488e-08 2.135e-06
143 TYROSINE PHOSPHORYLATION OF STAT PROTEIN 4 10 6.561e-08 2.135e-06
144 REGULATION OF ERBB SIGNALING PATHWAY 7 83 6.759e-08 2.184e-06
145 INFLAMMATORY RESPONSE 13 454 6.914e-08 2.219e-06
146 NEGATIVE REGULATION OF CELL PROLIFERATION 15 643 9.064e-08 2.889e-06
147 POSITIVE REGULATION OF CD4 POSITIVE ALPHA BETA T CELL ACTIVATION 5 27 9.793e-08 3.1e-06
148 B CELL ACTIVATION 8 132 1.002e-07 3.149e-06
149 LEUKOCYTE PROLIFERATION 7 88 1.016e-07 3.172e-06
150 RESPONSE TO VIRUS 10 247 1.07e-07 3.321e-06
151 EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 55 1.297e-07 3.996e-06
152 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 8 138 1.413e-07 4.327e-06
153 HOMEOSTATIC PROCESS 21 1337 1.571e-07 4.778e-06
154 RESPONSE TO STEROID HORMONE 13 497 1.963e-07 5.932e-06
155 RESPONSE TO ESTRADIOL 8 146 2.183e-07 6.552e-06
156 MYELOID LEUKOCYTE MIGRATION 7 99 2.293e-07 6.796e-06
157 LIPID PHOSPHORYLATION 7 99 2.293e-07 6.796e-06
158 RESPONSE TO INSULIN 9 205 2.436e-07 7.175e-06
159 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 11 351 3.144e-07 9.201e-06
160 BIOLOGICAL ADHESION 18 1032 3.164e-07 9.201e-06
161 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 17 926 3.488e-07 1.008e-05
162 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 14 616 3.51e-07 1.008e-05
163 REGULATION OF CHEMOKINE PRODUCTION 6 65 3.571e-07 1.019e-05
164 REGULATION OF MULTICELLULAR ORGANISM GROWTH 6 66 3.914e-07 1.111e-05
165 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 10 289 4.571e-07 1.289e-05
166 POSITIVE REGULATION OF ALPHA BETA T CELL DIFFERENTIATION 5 37 5.112e-07 1.433e-05
167 INTERFERON GAMMA MEDIATED SIGNALING PATHWAY 6 70 5.572e-07 1.552e-05
168 POSITIVE REGULATION OF INFLAMMATORY RESPONSE 7 113 5.667e-07 1.57e-05
169 REGULATION OF CD4 POSITIVE ALPHA BETA T CELL ACTIVATION 5 38 5.867e-07 1.615e-05
170 NEGATIVE REGULATION OF MOLECULAR FUNCTION 18 1079 6.063e-07 1.66e-05
171 REGULATION OF TYPE I INTERFERON MEDIATED SIGNALING PATHWAY 5 39 6.707e-07 1.825e-05
172 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 18 1087 6.749e-07 1.826e-05
173 GLUCOSE HOMEOSTASIS 8 170 6.978e-07 1.866e-05
174 CARBOHYDRATE HOMEOSTASIS 8 170 6.978e-07 1.866e-05
175 LEUKOCYTE CHEMOTAXIS 7 117 7.178e-07 1.909e-05
176 POSITIVE REGULATION OF MAPK CASCADE 12 470 7.806e-07 2.064e-05
177 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 17 983 8.013e-07 2.106e-05
178 NEGATIVE REGULATION OF IMMUNE RESPONSE 7 121 9.013e-07 2.356e-05
179 POSITIVE REGULATION OF T HELPER CELL DIFFERENTIATION 4 18 9.312e-07 2.421e-05
180 CELLULAR RESPONSE TO INTERFERON GAMMA 7 122 9.528e-07 2.463e-05
181 LOCOMOTION 18 1114 9.619e-07 2.473e-05
182 INOSITOL LIPID MEDIATED SIGNALING 7 124 1.063e-06 2.719e-05
183 REGULATION OF MAP KINASE ACTIVITY 10 319 1.122e-06 2.854e-05
184 ERBB SIGNALING PATHWAY 6 79 1.145e-06 2.896e-05
185 GROWTH 11 410 1.448e-06 3.643e-05
186 RESPONSE TO PROTOZOAN 4 20 1.465e-06 3.645e-05
187 RESPONSE TO LEPTIN 4 20 1.465e-06 3.645e-05
188 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 19 1275 1.528e-06 3.781e-05
189 REGULATION OF ALPHA BETA T CELL DIFFERENTIATION 5 46 1.559e-06 3.839e-05
190 REGULATION OF BODY FLUID LEVELS 12 506 1.688e-06 4.134e-05
191 REGULATION OF IMMUNOGLOBULIN PRODUCTION 5 47 1.739e-06 4.237e-05
192 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION OF STAT PROTEIN 4 21 1.803e-06 4.348e-05
193 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION OF STAT PROTEIN 4 21 1.803e-06 4.348e-05
194 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 8 193 1.814e-06 4.351e-05
195 CELLULAR RESPONSE TO INTERLEUKIN 6 4 22 2.197e-06 5.242e-05
196 CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 7 139 2.288e-06 5.433e-05
197 B CELL DIFFERENTIATION 6 89 2.314e-06 5.465e-05
198 PLATELET ACTIVATION 7 142 2.639e-06 6.167e-05
199 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 4 23 2.651e-06 6.167e-05
200 POSITIVE REGULATION OF ALPHA BETA T CELL ACTIVATION 5 51 2.628e-06 6.167e-05
201 RESPONSE TO INTERFERON GAMMA 7 144 2.896e-06 6.704e-05
202 NEGATIVE REGULATION OF MAPK CASCADE 7 145 3.033e-06 6.985e-05
203 LIPID MODIFICATION 8 210 3.4e-06 7.794e-05
204 GLYCEROLIPID BIOSYNTHETIC PROCESS 8 211 3.522e-06 8.034e-05
205 POSITIVE REGULATION OF DEFENSE RESPONSE 10 364 3.656e-06 8.297e-05
206 ADAPTIVE IMMUNE RESPONSE 9 288 4.098e-06 9.257e-05
207 REGULATION OF DEVELOPMENTAL GROWTH 9 289 4.215e-06 9.475e-05
208 REGULATION OF TYPE 2 IMMUNE RESPONSE 4 26 4.432e-06 9.773e-05
209 REGULATION OF T HELPER CELL DIFFERENTIATION 4 26 4.432e-06 9.773e-05
210 RESPONSE TO INTERLEUKIN 6 4 26 4.432e-06 9.773e-05
211 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 10 372 4.431e-06 9.773e-05
212 NEGATIVE REGULATION OF INFLAMMATORY RESPONSE 6 100 4.57e-06 9.984e-05
213 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 6 100 4.57e-06 9.984e-05
214 POSITIVE REGULATION OF IMMUNE EFFECTOR PROCESS 7 156 4.922e-06 0.000107
215 NEGATIVE REGULATION OF IMMUNE EFFECTOR PROCESS 6 102 5.128e-06 0.000111
216 NEGATIVE REGULATION OF CELL ADHESION 8 223 5.297e-06 0.0001141
217 T CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 5 60 5.927e-06 0.0001265
218 LEUKOCYTE HOMEOSTASIS 5 60 5.927e-06 0.0001265
219 POSITIVE REGULATION OF ACUTE INFLAMMATORY RESPONSE 4 28 6.03e-06 0.0001281
220 CELL CHEMOTAXIS 7 162 6.311e-06 0.0001329
221 POSITIVE REGULATION OF RESPONSE TO WOUNDING 7 162 6.311e-06 0.0001329
222 DEFENSE RESPONSE TO VIRUS 7 164 6.841e-06 0.0001434
223 PHOSPHOLIPID BIOSYNTHETIC PROCESS 8 235 7.779e-06 0.0001623
224 REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 5 65 8.814e-06 0.0001831
225 RESPONSE TO INTERLEUKIN 4 4 31 9.175e-06 0.0001889
226 POSITIVE REGULATION OF IMMUNOGLOBULIN PRODUCTION 4 31 9.175e-06 0.0001889
227 POSITIVE REGULATION OF GENE EXPRESSION 21 1733 1.022e-05 0.0002094
228 DEFENSE RESPONSE TO OTHER ORGANISM 11 505 1.057e-05 0.0002158
229 REGULATION OF ALPHA BETA T CELL ACTIVATION 5 68 1.101e-05 0.0002218
230 RESPONSE TO TYPE I INTERFERON 5 68 1.101e-05 0.0002218
231 ORGAN GROWTH 5 68 1.101e-05 0.0002218
232 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 14 829 1.121e-05 0.0002248
233 MAMMARY GLAND DEVELOPMENT 6 117 1.131e-05 0.0002259
234 POSITIVE REGULATION OF TYROSINE PHOSPHORYLATION OF STAT1 PROTEIN 3 11 1.235e-05 0.0002426
235 OXALOACETATE METABOLIC PROCESS 3 11 1.235e-05 0.0002426
236 CREATINE METABOLIC PROCESS 3 11 1.235e-05 0.0002426
237 REGULATION OF T HELPER 2 CELL DIFFERENTIATION 3 11 1.235e-05 0.0002426
238 INNATE IMMUNE RESPONSE 12 619 1.313e-05 0.0002567
239 REGULATION OF B CELL ACTIVATION 6 121 1.371e-05 0.000267
240 REGULATION OF MYELOID CELL DIFFERENTIATION 7 183 1.399e-05 0.0002712
241 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 6 122 1.437e-05 0.0002775
242 POSITIVE REGULATION OF ADAPTIVE IMMUNE RESPONSE 5 73 1.56e-05 3e-04
243 RESPONSE TO BACTERIUM 11 528 1.601e-05 0.0003065
244 NATURAL KILLER CELL DIFFERENTIATION 3 12 1.642e-05 0.0003119
245 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 3 12 1.642e-05 0.0003119
246 REGULATION OF ACUTE INFLAMMATORY RESPONSE 5 74 1.668e-05 0.0003141
247 NEGATIVE REGULATION OF HORMONE SECRETION 5 74 1.668e-05 0.0003141
248 POSITIVE REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 4 36 1.69e-05 0.000317
249 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 6 129 1.975e-05 0.000369
250 B CELL PROLIFERATION 4 38 2.104e-05 0.0003915
251 POSITIVE REGULATION OF PROTEIN IMPORT INTO NUCLEUS TRANSLOCATION 3 13 2.128e-05 0.000393
252 ENERGY HOMEOSTASIS 3 13 2.128e-05 0.000393
253 INSULIN RECEPTOR SIGNALING PATHWAY 5 80 2.439e-05 0.0004485
254 POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING 5 81 2.591e-05 0.0004746
255 CELLULAR RESPONSE TO LIPID 10 457 2.64e-05 0.0004818
256 LACTATION 4 41 2.858e-05 0.0005195
257 NEGATIVE REGULATION OF CELL CELL ADHESION 6 138 2.892e-05 0.0005237
258 POSITIVE REGULATION OF SECRETION 9 370 3.021e-05 0.0005449
259 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 10 465 3.06e-05 0.0005497
260 POSITIVE REGULATION OF LEUKOCYTE MEDIATED IMMUNITY 5 85 3.272e-05 0.0005856
261 NEGATIVE REGULATION OF PEPTIDYL THREONINE PHOSPHORYLATION 3 15 3.365e-05 0.0005976
262 T CELL LINEAGE COMMITMENT 3 15 3.365e-05 0.0005976
263 MYELOID LEUKOCYTE MEDIATED IMMUNITY 4 43 3.46e-05 0.0006057
264 POSITIVE REGULATION OF B CELL ACTIVATION 5 86 3.462e-05 0.0006057
265 REGULATION OF INSULIN RECEPTOR SIGNALING PATHWAY 4 43 3.46e-05 0.0006057
266 ACUTE PHASE RESPONSE 4 43 3.46e-05 0.0006057
267 NEGATIVE REGULATION OF DEFENSE RESPONSE 6 144 3.675e-05 0.0006381
268 RESPONSE TO GROWTH FACTOR 10 475 3.663e-05 0.0006381
269 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 8 296 4.089e-05 0.0007062
270 NEGATIVE REGULATION OF CHEMOKINE PRODUCTION 3 16 4.128e-05 0.0007062
271 CELLULAR RESPONSE TO LEPTIN STIMULUS 3 16 4.128e-05 0.0007062
272 REGULATION OF TYROSINE PHOSPHORYLATION OF STAT1 PROTEIN 3 16 4.128e-05 0.0007062
273 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 8 297 4.188e-05 0.0007137
274 REGULATION OF HYDROLASE ACTIVITY 17 1327 4.237e-05 0.0007196
275 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 7 218 4.3e-05 0.0007276
276 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 7 220 4.557e-05 0.0007682
277 RESPONSE TO ANTIBIOTIC 4 47 4.936e-05 0.0008291
278 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 3 17 4.997e-05 0.0008305
279 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 6 152 4.974e-05 0.0008305
280 REGULATION OF CELL CYCLE 14 949 4.985e-05 0.0008305
281 GLAND DEVELOPMENT 9 395 5.02e-05 0.0008312
282 POSITIVE REGULATION OF CELL DEATH 11 605 5.548e-05 0.0009155
283 NEGATIVE REGULATION OF CELLULAR CATABOLIC PROCESS 6 156 5.749e-05 0.0009419
284 NEGATIVE REGULATION OF RESPONSE TO WOUNDING 6 156 5.749e-05 0.0009419
285 HEMOSTASIS 8 311 5.791e-05 0.0009455
286 POSITIVE REGULATION OF CHEMOKINE PRODUCTION 4 49 5.825e-05 0.0009477
287 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 9 404 5.971e-05 0.0009681
288 HORMONE MEDIATED SIGNALING PATHWAY 6 158 6.171e-05 0.000997
289 REGULATION OF SYSTEM PROCESS 10 507 6.327e-05 0.001019
290 REPRODUCTIVE SYSTEM DEVELOPMENT 9 408 6.44e-05 0.001033
291 LYMPHOCYTE ACTIVATION INVOLVED IN IMMUNE RESPONSE 5 98 6.484e-05 0.001037
292 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 5 99 6.806e-05 0.001085
293 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 8 321 7.226e-05 0.001148
294 NEGATIVE REGULATION OF ERK1 AND ERK2 CASCADE 4 52 7.37e-05 0.001166
295 REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 5 101 7.487e-05 0.001181
296 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 8 323 7.546e-05 0.001186
297 NEGATIVE REGULATION OF HOMOTYPIC CELL CELL ADHESION 5 102 7.847e-05 0.001229
298 MAMMARY GLAND EPITHELIUM DEVELOPMENT 4 53 7.946e-05 0.001232
299 REGULATION OF NITRIC OXIDE BIOSYNTHETIC PROCESS 4 53 7.946e-05 0.001232
300 REGULATION OF LEUKOCYTE MEDIATED CYTOTOXICITY 4 53 7.946e-05 0.001232
301 MEGAKARYOCYTE DIFFERENTIATION 3 20 8.3e-05 0.001279
302 X2 OXOGLUTARATE METABOLIC PROCESS 3 20 8.3e-05 0.001279
303 MORPHOGENESIS OF A BRANCHING STRUCTURE 6 167 8.387e-05 0.001288
304 ALPHA BETA T CELL ACTIVATION 4 54 8.553e-05 0.001309
305 POSITIVE REGULATION OF PROTEIN IMPORT 5 104 8.606e-05 0.001309
306 REGULATION OF INTERLEUKIN 6 PRODUCTION 5 104 8.606e-05 0.001309
307 CHEMICAL HOMEOSTASIS 13 874 8.786e-05 0.001332
308 CELL DEATH 14 1001 8.832e-05 0.001334
309 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 14 1004 9.118e-05 0.001371
310 POSITIVE REGULATION OF CELL CYCLE 8 332 9.134e-05 0.001371
311 NEGATIVE REGULATION OF NEURON DEATH 6 171 9.557e-05 0.00143
312 REGULATION OF PROTEIN IMPORT INTO NUCLEUS TRANSLOCATION 3 21 9.654e-05 0.00144
313 REGULATION OF T HELPER 1 TYPE IMMUNE RESPONSE 3 22 0.0001114 0.001657
314 REGULATION OF DNA RECOMBINATION 4 58 0.0001133 0.001675
315 LIPID METABOLIC PROCESS 15 1158 0.0001134 0.001675
316 LEUKOCYTE APOPTOTIC PROCESS 3 23 0.0001277 0.001863
317 REGULATION OF METANEPHROS DEVELOPMENT 3 23 0.0001277 0.001863
318 BRANCHED CHAIN AMINO ACID METABOLIC PROCESS 3 23 0.0001277 0.001863
319 REGULATION OF CELLULAR PROTEIN LOCALIZATION 10 552 0.0001275 0.001863
320 REGULATION OF GLUCOSE IMPORT 4 60 0.0001293 0.001875
321 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 4 60 0.0001293 0.001875
322 RESPONSE TO KETONE 6 182 0.0001345 0.001944
323 REGULATION OF HORMONE SECRETION 7 262 0.000136 0.001954
324 CELLULAR LIPID METABOLIC PROCESS 13 913 0.0001359 0.001954
325 REGULATION OF PROTEIN IMPORT 6 183 0.0001386 0.001978
326 CELLULAR RESPONSE TO ALCOHOL 5 115 0.0001384 0.001978
327 REGULATION OF ISOTYPE SWITCHING 3 24 0.0001455 0.002071
328 GLYCEROLIPID METABOLIC PROCESS 8 356 0.0001477 0.002096
329 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 12 801 0.0001576 0.002228
330 CELLULAR EXTRAVASATION 3 25 0.0001649 0.002325
331 POSITIVE REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 4 64 0.0001663 0.002338
332 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 19 1784 0.0001683 0.002358
333 CYTOKINE PRODUCTION 5 120 0.000169 0.002361
334 TAXIS 9 464 0.0001705 0.002375
335 PHOSPHOLIPID METABOLIC PROCESS 8 364 0.000172 0.002388
336 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 5 121 0.0001757 0.002426
337 REGULATION OF PROTEIN KINASE B SIGNALING 5 121 0.0001757 0.002426
338 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 7 274 0.0001792 0.002467
339 CELLULAR RESPONSE TO INTERLEUKIN 4 3 26 0.0001858 0.002543
340 CELLULAR RESPONSE TO VITAMIN 3 26 0.0001858 0.002543
341 CELLULAR RESPONSE TO UV 4 66 0.0001874 0.002553
342 WOUND HEALING 9 470 0.0001876 0.002553
343 EPITHELIUM DEVELOPMENT 13 945 0.0001908 0.002588
344 ACTIVATION OF PROTEIN KINASE ACTIVITY 7 279 0.0002002 0.002708
345 REGULATION OF NATURAL KILLER CELL ACTIVATION 3 27 0.0002084 0.00281
346 RESPONSE TO UV 5 126 0.0002123 0.002854
347 REGULATION OF LIPID METABOLIC PROCESS 7 282 0.0002137 0.002866
348 TISSUE DEVELOPMENT 17 1518 0.0002194 0.002934
349 POSITIVE REGULATION OF LYMPHOCYTE MEDIATED IMMUNITY 4 69 0.0002226 0.002968
350 NEGATIVE REGULATION OF SECRETION 6 200 0.0002245 0.002984
351 REGULATION OF EPITHELIAL CELL PROLIFERATION 7 285 0.000228 0.003019
352 NEGATIVE REGULATION OF HEMOPOIESIS 5 128 0.0002284 0.003019
353 POSITIVE REGULATION OF ACTIVATED T CELL PROLIFERATION 3 28 0.0002327 0.003067
354 NUCLEAR IMPORT 5 129 0.0002368 0.003113
355 NEGATIVE REGULATION OF CATABOLIC PROCESS 6 203 0.0002432 0.003188
356 BODY FLUID SECRETION 4 71 0.0002486 0.003249
357 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 10 602 0.0002568 0.003346
358 T CELL DIFFERENTIATION INVOLVED IN IMMUNE RESPONSE 3 29 0.0002587 0.003362
359 ENERGY RESERVE METABOLIC PROCESS 4 72 0.0002624 0.0034
360 REGULATION OF PROTEIN SECRETION 8 389 0.0002696 0.003485
361 NEGATIVE REGULATION OF MAP KINASE ACTIVITY 4 73 0.0002767 0.003556
362 ACUTE INFLAMMATORY RESPONSE 4 73 0.0002767 0.003556
363 NEGATIVE REGULATION OF CELL DIFFERENTIATION 10 609 0.0002815 0.003609
364 REGULATION OF CATABOLIC PROCESS 11 731 0.0002912 0.003722
365 POSITIVE REGULATION OF PROTEIN SECRETION 6 211 0.0002993 0.003805
366 NEGATIVE REGULATION OF CYTOKINE PRODUCTION 6 211 0.0002993 0.003805
367 RESPONSE TO ETHANOL 5 136 0.0003025 0.003835
368 GRANULOCYTE MIGRATION 4 75 0.0003069 0.003881
369 CELLULAR RESPONSE TO RADIATION 5 137 0.0003129 0.003946
370 NEGATIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 3 31 0.0003163 0.003967
371 HOMEOSTASIS OF NUMBER OF CELLS WITHIN A TISSUE 3 31 0.0003163 0.003967
372 REPRODUCTION 15 1297 0.0003878 0.00485
373 REGULATION OF PROTEIN DEACETYLATION 3 34 0.0004172 0.005202
374 CELLULAR RESPONSE TO INSULIN STIMULUS 5 146 0.0004192 0.005202
375 T CELL RECEPTOR SIGNALING PATHWAY 5 146 0.0004192 0.005202
376 NEGATIVE REGULATION OF LEUKOCYTE DIFFERENTIATION 4 82 0.0004317 0.005342
377 ORGAN REGENERATION 4 83 0.0004521 0.00558
378 FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 4 84 0.0004732 0.005824
379 T CELL PROLIFERATION 3 36 0.0004947 0.006041
380 NEGATIVE REGULATION OF BLOOD CIRCULATION 3 36 0.0004947 0.006041
381 T CELL SELECTION 3 36 0.0004947 0.006041
382 LIPID BIOSYNTHETIC PROCESS 9 539 0.0005114 0.006229
383 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 4 86 0.0005174 0.006285
384 NEGATIVE REGULATION OF ADAPTIVE IMMUNE RESPONSE 3 37 0.0005366 0.006436
385 TRICARBOXYLIC ACID METABOLIC PROCESS 3 37 0.0005366 0.006436
386 RESPONSE TO DRUG 8 431 0.0005331 0.006436
387 REGULATION OF PEPTIDYL THREONINE PHOSPHORYLATION 3 37 0.0005366 0.006436
388 NEGATIVE REGULATION OF EPITHELIAL CELL DIFFERENTIATION 3 37 0.0005366 0.006436
389 PROTEIN IMPORT 5 155 0.0005508 0.006589
390 DEFENSE RESPONSE TO BACTERIUM 6 237 0.0005544 0.006614
391 REGULATION OF ERK1 AND ERK2 CASCADE 6 238 0.0005668 0.006715
392 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 5 156 0.0005672 0.006715
393 PROTEIN LOCALIZATION TO NUCLEUS 5 156 0.0005672 0.006715
394 REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 3 38 0.0005808 0.006825
395 REGULATION OF GLUCONEOGENESIS 3 38 0.0005808 0.006825
396 DEVELOPMENTAL GROWTH 7 333 0.0005806 0.006825
397 EPITHELIAL CELL PROLIFERATION 4 89 0.0005891 0.006904
398 NEGATIVE REGULATION OF CELL ACTIVATION 5 158 0.0006009 0.007025
399 REGULATION OF GTPASE ACTIVITY 10 673 0.0006162 0.007186
400 ERBB2 SIGNALING PATHWAY 3 39 0.0006273 0.007225
401 ASTROCYTE DIFFERENTIATION 3 39 0.0006273 0.007225
402 CELLULAR RESPONSE TO NUTRIENT 3 39 0.0006273 0.007225
403 POSITIVE REGULATION OF CELL KILLING 3 39 0.0006273 0.007225
404 EMBRYO IMPLANTATION 3 39 0.0006273 0.007225
405 CELLULAR RESPONSE TO LIGHT STIMULUS 4 91 0.0006406 0.00736
406 POSITIVE REGULATION OF TRANSPORT 12 936 0.0006459 0.007402
407 REGENERATION 5 161 0.0006544 0.007481
408 REGULATION OF DNA METABOLIC PROCESS 7 340 0.0006565 0.007487
409 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 3 40 0.0006761 0.007672
410 REGULATION OF ACTIVATED T CELL PROLIFERATION 3 40 0.0006761 0.007672
411 RESPONSE TO WOUNDING 9 563 0.0006983 0.007905
412 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 8 450 0.0007068 0.007982
413 REGULATION OF AUTOPHAGY 6 249 0.000718 0.008089
414 REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 4 94 0.0007238 0.008135
415 REGULATION OF B CELL MEDIATED IMMUNITY 3 41 0.0007272 0.008153
416 REGULATION OF NEURON DEATH 6 252 0.0007642 0.008547
417 POSITIVE REGULATION OF GLUCOSE TRANSPORT 3 42 0.0007807 0.008711
418 REGULATION OF INTERFERON GAMMA PRODUCTION 4 97 0.0008144 0.009044
419 REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 4 97 0.0008144 0.009044
420 REGULATION OF SECRETION 10 699 0.0008242 0.009131
421 REGULATION OF PEPTIDE TRANSPORT 6 256 0.0008293 0.009166
422 REGULATION OF MUSCLE CELL APOPTOTIC PROCESS 3 43 0.0008366 0.009181
423 DEFENSE RESPONSE TO GRAM NEGATIVE BACTERIUM 3 43 0.0008366 0.009181
424 BETA CATENIN TCF COMPLEX ASSEMBLY 3 43 0.0008366 0.009181
425 RESPONSE TO VITAMIN 4 98 0.0008463 0.009266
426 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 5 172 0.0008812 0.009625
427 REGULATION OF GLUCOSE TRANSPORT 4 100 0.0009128 0.009946
428 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 7 360 0.0009176 0.009975
NumGOOverlapSizeP ValueAdj. P Value
1 CYTOKINE RECEPTOR ACTIVITY 26 89 7.584e-42 7.045e-39
2 CYTOKINE RECEPTOR BINDING 22 271 2.653e-22 1.232e-19
3 RECEPTOR BINDING 35 1476 6.123e-18 1.896e-15
4 SIGNAL TRANSDUCER ACTIVITY 36 1731 1.137e-16 2.112e-14
5 CYTOKINE BINDING 13 92 1.134e-16 2.112e-14
6 KINASE REGULATOR ACTIVITY 14 186 5.592e-14 8.658e-12
7 CYTOKINE ACTIVITY 13 219 9.8e-12 1.301e-09
8 KINASE BINDING 18 606 8.094e-11 8.355e-09
9 SIGNALING RECEPTOR ACTIVITY 26 1393 8.058e-11 8.355e-09
10 KINASE INHIBITOR ACTIVITY 9 89 1.572e-10 1.46e-08
11 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 43 6.025e-10 4.552e-08
12 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 8 70 6.369e-10 4.552e-08
13 INSULIN RECEPTOR SUBSTRATE BINDING 5 11 5.915e-10 4.552e-08
14 MOLECULAR FUNCTION REGULATOR 24 1353 1.459e-09 9.681e-08
15 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 7 51 2.106e-09 1.304e-07
16 RECEPTOR ACTIVITY 26 1649 3.04e-09 1.765e-07
17 GROWTH FACTOR RECEPTOR BINDING 9 129 4.41e-09 2.41e-07
18 KINASE ACTIVITY 18 842 1.481e-08 7.645e-07
19 ENZYME BINDING 25 1737 4.145e-08 2.027e-06
20 HORMONE RECEPTOR BINDING 9 168 4.439e-08 2.062e-06
21 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 18 992 1.765e-07 7.809e-06
22 PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY 4 16 5.575e-07 2.354e-05
23 GROWTH FACTOR BINDING 7 123 1.007e-06 4.067e-05
24 ENZYME REGULATOR ACTIVITY 16 959 2.827e-06 0.0001094
25 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 8 228 6.234e-06 0.0002317
26 PROTEIN KINASE ACTIVITY 12 640 1.828e-05 0.0006532
27 GLUCOCORTICOID RECEPTOR BINDING 3 14 2.7e-05 0.0009291
28 ENZYME INHIBITOR ACTIVITY 9 378 3.57e-05 0.001184
29 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 8 303 4.822e-05 0.001545
30 PEPTIDE HORMONE RECEPTOR BINDING 3 17 4.997e-05 0.001548
31 GROWTH FACTOR ACTIVITY 6 160 6.617e-05 0.001983
32 PHOSPHATASE BINDING 6 162 7.089e-05 0.002058
33 RNA POLYMERASE II CORE PROMOTER SEQUENCE SPECIFIC DNA BINDING 4 53 7.946e-05 0.002237
34 PROTEIN TYROSINE KINASE ACTIVITY 6 176 0.000112 0.003059
35 PROTEIN PHOSPHATASE BINDING 5 120 0.000169 0.004486
36 PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 3 30 0.0002866 0.007395
NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 7 20 1.57e-12 9.166e-10
2 RECEPTOR COMPLEX 12 327 1.546e-08 4.514e-06
3 EXTRACELLULAR SPACE 22 1376 5.394e-08 1.05e-05
4 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 10 237 7.274e-08 1.062e-05
5 EXTRINSIC COMPONENT OF MEMBRANE 10 252 1.29e-07 1.507e-05
6 PLASMA MEMBRANE RECEPTOR COMPLEX 8 175 8.689e-07 8.458e-05
7 MEMBRANE PROTEIN COMPLEX 16 1020 6.205e-06 0.0005177
8 EXTERNAL SIDE OF PLASMA MEMBRANE 8 238 8.534e-06 0.000623
9 SIDE OF MEMBRANE 10 428 1.506e-05 0.0009772
10 TRANSFERASE COMPLEX 12 703 4.574e-05 0.002671
11 INTRINSIC COMPONENT OF PLASMA MEMBRANE 19 1649 5.924e-05 0.003145
12 CELL SURFACE 12 757 9.277e-05 0.004515

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04630_Jak.STAT_signaling_pathway 86 155 4.344e-195 7.819e-193
2 hsa04151_PI3K_AKT_signaling_pathway 29 351 1.04e-29 9.363e-28
3 hsa04012_ErbB_signaling_pathway 15 87 1.809e-20 1.085e-18
4 hsa04380_Osteoclast_differentiation 16 128 2.001e-19 9.003e-18
5 hsa04660_T_cell_receptor_signaling_pathway 14 108 2.469e-17 7.569e-16
6 hsa04910_Insulin_signaling_pathway 15 138 2.523e-17 7.569e-16
7 hsa04062_Chemokine_signaling_pathway 15 189 2.96e-15 7.613e-14
8 hsa04650_Natural_killer_cell_mediated_cytotoxicity 13 136 2.114e-14 4.757e-13
9 hsa04620_Toll.like_receptor_signaling_pathway 11 102 6.224e-13 1.245e-11
10 hsa04662_B_cell_receptor_signaling_pathway 10 75 8.323e-13 1.498e-11
11 hsa04664_Fc_epsilon_RI_signaling_pathway 10 79 1.427e-12 2.334e-11
12 hsa04510_Focal_adhesion 13 200 3.103e-12 4.654e-11
13 hsa04640_Hematopoietic_cell_lineage 10 88 4.332e-12 5.999e-11
14 hsa04210_Apoptosis 10 89 4.864e-12 6.254e-11
15 hsa04722_Neurotrophin_signaling_pathway 11 127 7.128e-12 8.554e-11
16 hsa04973_Carbohydrate_digestion_and_absorption 8 44 1.309e-11 1.472e-10
17 hsa04150_mTOR_signaling_pathway 8 52 5.405e-11 5.723e-10
18 hsa04960_Aldosterone.regulated_sodium_reabsorption 7 42 5.062e-10 5.062e-09
19 hsa04370_VEGF_signaling_pathway 8 76 1.246e-09 1.18e-08
20 hsa04914_Progesterone.mediated_oocyte_maturation 8 87 3.716e-09 3.345e-08
21 hsa04666_Fc_gamma_R.mediated_phagocytosis 8 95 7.519e-09 6.445e-08
22 hsa04920_Adipocytokine_signaling_pathway 7 68 1.662e-08 1.36e-07
23 hsa04670_Leukocyte_transendothelial_migration 8 117 3.908e-08 3.058e-07
24 hsa04070_Phosphatidylinositol_signaling_system 7 78 4.376e-08 3.282e-07
25 hsa04014_Ras_signaling_pathway 10 236 6.991e-08 5.034e-07
26 hsa04810_Regulation_of_actin_cytoskeleton 9 214 3.502e-07 2.425e-06
27 hsa04110_Cell_cycle 6 128 1.889e-05 0.000126
28 hsa04310_Wnt_signaling_pathway 6 151 4.794e-05 0.0003082
29 hsa04672_Intestinal_immune_network_for_IgA_production 4 49 5.825e-05 0.0003615
30 hsa00562_Inositol_phosphate_metabolism 4 57 0.0001058 0.0006347
31 hsa04120_Ubiquitin_mediated_proteolysis 5 139 0.0003345 0.001942
32 hsa04350_TGF.beta_signaling_pathway 4 85 0.0004949 0.002784
33 hsa04144_Endocytosis 5 203 0.001836 0.01001
34 hsa04115_p53_signaling_pathway 3 69 0.003278 0.01735
35 hsa04390_Hippo_signaling_pathway 4 154 0.004402 0.02264
36 hsa04320_Dorso.ventral_axis_formation 2 25 0.005141 0.02571
37 hsa04330_Notch_signaling_pathway 2 47 0.01743 0.08479
38 hsa04010_MAPK_signaling_pathway 4 268 0.02847 0.1349
39 hsa04720_Long.term_potentiation 2 70 0.03655 0.1687
40 hsa04622_RIG.I.like_receptor_signaling_pathway 2 71 0.0375 0.1688
41 hsa04520_Adherens_junction 2 73 0.03945 0.1732
42 hsa04540_Gap_junction 2 90 0.05739 0.2459
43 hsa04912_GnRH_signaling_pathway 2 101 0.07023 0.2873
44 hsa04916_Melanogenesis 2 101 0.07023 0.2873

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

EMX2OS

 hsa-let-7a-3p;hsa-let-7d-5p;hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-15b-3p;hsa-miR-19b-1-5p;hsa-miR-20a-3p;hsa-miR-22-5p;hsa-miR-32-3p;hsa-miR-330-3p;hsa-miR-3614-5p;hsa-miR-421;hsa-miR-944 13 PRLR Sponge network -6.205 0.00015 -5.28 0.00088 0.479
2

HAND2-AS1

 hsa-let-7a-3p;hsa-let-7d-5p;hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-15b-3p;hsa-miR-19b-1-5p;hsa-miR-20a-3p;hsa-miR-22-5p;hsa-miR-32-3p;hsa-miR-330-3p;hsa-miR-33a-3p;hsa-miR-3614-5p;hsa-miR-421;hsa-miR-944 14 PRLR Sponge network -7.871 0 -5.28 0.00088 0.478
3 RP11-760H22.2 hsa-let-7a-3p;hsa-let-7d-5p;hsa-let-7f-1-3p;hsa-miR-142-3p;hsa-miR-15b-3p;hsa-miR-20a-3p;hsa-miR-22-5p;hsa-miR-320b;hsa-miR-9-3p;hsa-miR-944 10 PRLR Sponge network -3.418 0.00912 -5.28 0.00088 0.447
4

RP11-166D19.1

 hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-27a-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p;hsa-miR-9-5p;hsa-miR-944 11 LIFR Sponge network -4.209 2.0E-5 -4.51 1.0E-5 0.442
5 LINC00284 hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-142-3p;hsa-miR-155-5p;hsa-miR-15b-3p;hsa-miR-21-3p;hsa-miR-330-5p;hsa-miR-590-3p;hsa-miR-708-5p;hsa-miR-944 10 SPRY3 Sponge network -5.478 0.02716 -0.618 0.35993 0.417
6 AC005682.5 hsa-miR-106a-5p;hsa-miR-10a-3p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-182-5p;hsa-miR-191-5p;hsa-miR-200a-3p;hsa-miR-20b-5p;hsa-miR-28-5p;hsa-miR-3065-3p;hsa-miR-3065-5p 11 CCND2 Sponge network -2.193 0.07184 -2.811 0.0014 0.394
7 FAM66C hsa-let-7a-3p;hsa-let-7d-5p;hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-142-3p;hsa-miR-15b-3p;hsa-miR-19b-1-5p;hsa-miR-20a-3p;hsa-miR-22-5p;hsa-miR-3614-5p 10 PRLR Sponge network -2.927 0.00012 -5.28 0.00088 0.392
8

MAGI2-AS3

 hsa-let-7a-3p;hsa-let-7d-5p;hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-142-3p;hsa-miR-15b-3p;hsa-miR-19b-1-5p;hsa-miR-20a-3p;hsa-miR-32-3p;hsa-miR-320b;hsa-miR-33a-3p;hsa-miR-3614-5p;hsa-miR-9-3p 13 PRLR Sponge network -4.563 0 -5.28 0.00088 0.391
9

HAND2-AS1

 hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-205-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-27a-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-629-3p;hsa-miR-944 10 LIFR Sponge network -7.871 0 -4.51 1.0E-5 0.386
10 RP11-244O19.1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-141-3p;hsa-miR-15b-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-191-5p;hsa-miR-200a-3p;hsa-miR-3065-3p;hsa-miR-3065-5p;hsa-miR-30d-3p;hsa-miR-93-5p 12 CCND2 Sponge network -1.318 0.0924 -2.811 0.0014 0.383
11 DIO3OS hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-191-5p;hsa-miR-200a-3p;hsa-miR-20b-5p;hsa-miR-324-3p;hsa-miR-378a-3p 13 CCND2 Sponge network -4.295 0.00689 -2.811 0.0014 0.374
12

RP11-166D19.1

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-191-5p;hsa-miR-200a-3p;hsa-miR-20b-5p;hsa-miR-224-3p;hsa-miR-324-3p;hsa-miR-33a-3p;hsa-miR-378a-3p;hsa-miR-429;hsa-miR-550a-5p;hsa-miR-96-5p 18 CCND2 Sponge network -4.209 2.0E-5 -2.811 0.0014 0.339
13 RP11-439M11.1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-191-5p;hsa-miR-20b-5p;hsa-miR-324-3p 10 CCND2 Sponge network -2.662 0.21003 -2.811 0.0014 0.337
14

MAGI2-AS3

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-191-5p;hsa-miR-200a-3p;hsa-miR-20b-5p;hsa-miR-224-3p;hsa-miR-3065-5p;hsa-miR-30d-3p;hsa-miR-33a-3p;hsa-miR-378a-3p;hsa-miR-429;hsa-miR-9-3p;hsa-miR-93-5p 19 CCND2 Sponge network -4.563 0 -2.811 0.0014 0.315
15 RP11-284N8.3 hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-200a-3p;hsa-miR-3065-5p;hsa-miR-324-3p;hsa-miR-93-5p;hsa-miR-96-5p 10 CCND2 Sponge network -0.845 0.52848 -2.811 0.0014 0.313
16

EMX2OS

 hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-1271-5p;hsa-miR-155-5p;hsa-miR-15b-3p;hsa-miR-21-3p;hsa-miR-330-3p;hsa-miR-330-5p;hsa-miR-590-3p;hsa-miR-944 10 SPRY3 Sponge network -6.205 0.00015 -0.618 0.35993 0.312
17

RP11-166D19.1

 hsa-let-7d-5p;hsa-let-7f-1-3p;hsa-miR-142-3p;hsa-miR-15b-3p;hsa-miR-19b-1-5p;hsa-miR-20a-3p;hsa-miR-33a-3p;hsa-miR-3614-5p;hsa-miR-9-5p;hsa-miR-944 10 PRLR Sponge network -4.209 2.0E-5 -5.28 0.00088 0.309
18

ACTA2-AS1

 hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-142-3p;hsa-miR-155-5p;hsa-miR-15b-3p;hsa-miR-21-3p;hsa-miR-296-5p;hsa-miR-590-3p;hsa-miR-708-5p;hsa-miR-944 10 SPRY3 Sponge network -6.142 0.00223 -0.618 0.35993 0.306
19

MIR143HG

 hsa-miR-107;hsa-miR-130b-5p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-19b-3p;hsa-miR-25-3p;hsa-miR-324-5p;hsa-miR-363-3p;hsa-miR-429;hsa-miR-940 10 SOCS2 Sponge network -6.51 0 -3.753 1.0E-5 0.303
20 GAS6-AS2 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-15b-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-191-5p;hsa-miR-200a-3p;hsa-miR-20b-5p;hsa-miR-28-5p;hsa-miR-3065-5p;hsa-miR-324-3p;hsa-miR-429 14 CCND2 Sponge network -1.941 0.0681 -2.811 0.0014 0.301
21 TRHDE-AS1 hsa-let-7d-5p;hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-15b-3p;hsa-miR-19b-1-5p;hsa-miR-22-5p;hsa-miR-32-3p;hsa-miR-330-3p;hsa-miR-3614-5p;hsa-miR-582-5p 10 PRLR Sponge network -6.205 0.01165 -5.28 0.00088 0.297
22

MAGI2-AS3

 hsa-miR-107;hsa-miR-130b-5p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-19b-3p;hsa-miR-25-3p;hsa-miR-324-5p;hsa-miR-363-3p;hsa-miR-429;hsa-miR-940 10 SOCS2 Sponge network -4.563 0 -3.753 1.0E-5 0.295
23 RP11-389C8.2 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-191-5p;hsa-miR-200a-3p;hsa-miR-224-3p;hsa-miR-3065-3p;hsa-miR-3065-5p;hsa-miR-33a-3p;hsa-miR-429;hsa-miR-550a-5p;hsa-miR-93-5p 17 CCND2 Sponge network -3.089 2.0E-5 -2.811 0.0014 0.293
24

ACTA2-AS1

 hsa-let-7a-3p;hsa-let-7d-5p;hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130a-3p;hsa-miR-142-3p;hsa-miR-15b-3p;hsa-miR-19b-1-5p;hsa-miR-20a-3p;hsa-miR-22-5p;hsa-miR-33a-3p;hsa-miR-3614-5p;hsa-miR-944 13 PRLR Sponge network -6.142 0.00223 -5.28 0.00088 0.291
25 RP11-554A11.4 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-15b-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-191-5p;hsa-miR-20b-5p;hsa-miR-324-3p;hsa-miR-33a-3p 10 CCND2 Sponge network -5.361 2.0E-5 -2.811 0.0014 0.29
26 NR2F2-AS1 hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-1271-5p;hsa-miR-142-3p;hsa-miR-155-5p;hsa-miR-15b-3p;hsa-miR-21-3p;hsa-miR-590-3p;hsa-miR-708-5p;hsa-miR-944 10 SPRY3 Sponge network -3.785 0.00281 -0.618 0.35993 0.288
27

WT1-AS

 hsa-let-7d-5p;hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-15b-3p;hsa-miR-19b-1-5p;hsa-miR-20a-3p;hsa-miR-22-5p;hsa-miR-32-3p;hsa-miR-33a-3p;hsa-miR-421;hsa-miR-9-3p;hsa-miR-9-5p;hsa-miR-944 13 PRLR Sponge network -6.875 2.0E-5 -5.28 0.00088 0.286
28

MIR143HG

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-191-5p;hsa-miR-200a-3p;hsa-miR-20b-5p;hsa-miR-224-3p;hsa-miR-3065-3p;hsa-miR-3065-5p;hsa-miR-30d-3p;hsa-miR-324-3p;hsa-miR-33a-3p;hsa-miR-378a-3p;hsa-miR-429;hsa-miR-550a-5p;hsa-miR-93-5p 21 CCND2 Sponge network -6.51 0 -2.811 0.0014 0.285
29

DNM3OS

 hsa-let-7d-5p;hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-142-3p;hsa-miR-15b-3p;hsa-miR-19b-1-5p;hsa-miR-20a-3p;hsa-miR-320b;hsa-miR-330-3p;hsa-miR-33a-3p 10 PRLR Sponge network -3.933 0.00059 -5.28 0.00088 0.279
30

ADAMTS9-AS1

 hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-205-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-27a-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-629-3p 10 LIFR Sponge network -8.573 0.00012 -4.51 1.0E-5 0.275
31

MIR143HG

 hsa-let-7d-5p;hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-142-3p;hsa-miR-15b-3p;hsa-miR-19b-1-5p;hsa-miR-20a-3p;hsa-miR-330-3p;hsa-miR-33a-3p;hsa-miR-3614-5p 10 PRLR Sponge network -6.51 0 -5.28 0.00088 0.267
32 SOCS2-AS1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-15b-5p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-200a-3p;hsa-miR-20b-5p;hsa-miR-324-3p;hsa-miR-33a-3p;hsa-miR-93-5p 12 CCND2 Sponge network -4.167 1.0E-5 -2.811 0.0014 0.258
33 RP11-597D13.9 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-200a-3p;hsa-miR-20b-5p;hsa-miR-30d-3p;hsa-miR-429;hsa-miR-93-5p;hsa-miR-96-5p 14 CCND2 Sponge network -2.494 0.07597 -2.811 0.0014 0.252
34

DNM3OS

 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-191-5p;hsa-miR-200a-3p;hsa-miR-3065-3p;hsa-miR-3065-5p;hsa-miR-30d-3p;hsa-miR-33a-3p;hsa-miR-378a-3p;hsa-miR-429;hsa-miR-550a-5p;hsa-miR-93-5p;hsa-miR-96-5p 19 CCND2 Sponge network -3.933 0.00059 -2.811 0.0014 0.25

Quest ID: 6c077121325e8456fd49b18d18d56440