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show label of nodes with degree >=

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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-28-5p ARL6IP4 -0.43 0 0.01 0.90828 miRanda -0.12 0.03055 NA
2 hsa-miR-92b-3p ARL6IP4 0.22 0.29619 0.01 0.90828 miRNAWalker2 validate -0.1 2.0E-5 NA
3 hsa-miR-30a-5p HNRNPA1L2 -0.63 0.00011 0.46 0 miRNAWalker2 validate -0.1 2.0E-5 NA
4 hsa-miR-29a-5p IGF2-AS -0.11 0.34962 -1.27 0.168 mirMAP -0.66 0.0155 NA
5 hsa-miR-320a MDP1 0.33 0.02214 -0.5 8.0E-5 miRanda -0.14 0.00197 NA
6 hsa-miR-501-3p MDP1 1 0 -0.5 8.0E-5 miRNATAP -0.16 5.0E-5 NA
7 hsa-miR-502-3p MDP1 0.66 0 -0.5 8.0E-5 miRNATAP -0.13 0.01045 NA
8 hsa-miR-542-3p OGFOD2 -1.31 0 0.29 0.00101 miRanda -0.19 0 NA
9 hsa-miR-107 RGS5 0.24 0.01708 1.14 0 miRanda -0.22 0.02157 NA
10 hsa-miR-142-3p RGS5 -1.42 0 1.14 0 miRNAWalker2 validate -0.14 0.00655 NA
11 hsa-miR-142-5p RGS5 -1.45 0 1.14 0 mirMAP -0.15 0.00168 NA
12 hsa-miR-146a-5p RGS5 -0.74 0.00077 1.14 0 MirTarget -0.13 0.00206 NA
13 hsa-miR-146b-5p RGS5 0.42 0.04574 1.14 0 MirTarget; miRanda -0.14 0.00208 NA
14 hsa-miR-148a-5p RGS5 -0.77 0 1.14 0 mirMAP -0.25 4.0E-5 NA
15 hsa-miR-15b-3p RGS5 0.24 0.09977 1.14 0 mirMAP -0.19 0.00415 NA
16 hsa-miR-16-2-3p RGS5 -0.03 0.80516 1.14 0 MirTarget -0.25 0.0004 NA
17 hsa-miR-186-5p RGS5 -0.06 0.53529 1.14 0 mirMAP; miRNATAP -0.26 0.01127 NA
18 hsa-miR-29a-5p RGS5 -0.11 0.34962 1.14 0 mirMAP -0.2 0.01407 NA
19 hsa-miR-32-3p RGS5 0.22 0.20722 1.14 0 mirMAP -0.14 0.01921 NA
20 hsa-miR-33a-3p RGS5 -0.68 1.0E-5 1.14 0 MirTarget -0.19 0.00272 NA
21 hsa-miR-33a-5p RGS5 -0.77 1.0E-5 1.14 0 mirMAP -0.15 0.00788 NA
22 hsa-miR-33b-5p RGS5 -2.29 0 1.14 0 mirMAP -0.14 0.00036 NA
23 hsa-miR-590-3p RGS5 -0.47 2.0E-5 1.14 0 MirTarget; miRanda; miRNATAP -0.25 0.00393 NA
24 hsa-miR-628-3p RGS5 -0.96 0 1.14 0 mirMAP -0.12 0.02711 NA
25 hsa-miR-7-1-3p RGS5 -0.57 2.0E-5 1.14 0 mirMAP -0.21 0.00442 NA
26 hsa-miR-342-3p SDHAP2 -0.32 0.04498 0.54 0 miRanda -0.12 0.00015 NA
27 hsa-miR-28-5p SERHL -0.43 0 1.04 0 miRanda -0.29 0.00112 NA
28 hsa-miR-29a-3p SPNS1 -0.86 0 0.74 0 miRNATAP -0.17 0 NA
29 hsa-miR-29c-3p SPNS1 -1.44 0 0.74 0 miRNATAP -0.17 0 NA
30 hsa-miR-664a-5p SPNS1 -0.07 0.59768 0.74 0 MirTarget -0.13 5.0E-5 NA
31 hsa-miR-139-5p ZNF337 -2.11 0 0.77 0 miRanda -0.17 0 NA
32 hsa-miR-326 ZNF337 -1.88 0 0.77 0 miRanda -0.12 0 NA
33 hsa-miR-486-5p ZNF337 -1.78 0 0.77 0 miRanda -0.1 0 NA
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value

Quest ID: 6d005f9854c7535dc58303c90a464e14