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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-128-3p A2M 0 0 0 0 miRNAWalker2 validate -0.21 0 NA
2 hsa-miR-361-5p AAK1 0 0 0 0 PITA -0.21 0 NA
3 hsa-miR-23b-3p AARS2 0 0 0 0 miRNAWalker2 validate -0.12 0 NA
4 hsa-miR-374a-5p ABAT 0 0 0 0 MirTarget -0.6 0 NA
5 hsa-miR-374b-5p ABAT 0 0 0 0 MirTarget; miRNATAP -0.68 0 NA
6 hsa-miR-128-3p ABCA1 0 0 0 0 MirTarget -0.28 0 NA
7 hsa-miR-361-5p ABCA1 0 0 0 0 miRanda; mirMAP -0.27 4.0E-5 NA
8 hsa-miR-450b-5p ABCA1 0 0 0 0 PITA; mirMAP; miRNATAP -0.13 6.0E-5 NA
9 hsa-miR-23a-3p ABCA10 0 0 0 0 MirTarget -0.48 1.0E-5 NA
10 hsa-miR-23b-3p ABCA10 0 0 0 0 MirTarget -0.21 0.02104 NA
11 hsa-miR-361-5p ABCB10 0 0 0 0 MirTarget; miRanda -0.16 4.0E-5 NA
12 hsa-miR-374a-5p ABCB10 0 0 0 0 mirMAP -0.12 1.0E-5 NA
13 hsa-miR-339-5p ABCB5 0 0 0 0 miRanda -0.31 0.00043 NA
14 hsa-miR-224-5p ABCC5 0 0 0 0 mirMAP -0.12 0 NA
15 hsa-miR-542-3p ABCC9 0 0 0 0 miRanda -0.12 0.01472 NA
16 hsa-miR-374a-5p ABCD3 0 0 0 0 MirTarget -0.2 0 NA
17 hsa-miR-374b-5p ABCD3 0 0 0 0 MirTarget -0.22 0 NA
18 hsa-miR-542-3p ABHD15 0 0 0 0 miRanda -0.17 0 NA
19 hsa-miR-224-5p ABHD2 0 0 0 0 mirMAP -0.14 0 NA
20 hsa-miR-361-5p ABHD2 0 0 0 0 PITA; mirMAP -0.59 0 NA
21 hsa-miR-452-5p ABHD2 0 0 0 0 mirMAP -0.22 0 NA
22 hsa-miR-542-3p ABHD6 0 0 0 0 miRanda -0.12 3.0E-5 NA
23 hsa-miR-361-5p ABL2 0 0 0 0 mirMAP -0.16 2.0E-5 NA
24 hsa-miR-374a-5p ABL2 0 0 0 0 mirMAP -0.13 0 NA
25 hsa-miR-450b-5p ABLIM3 0 0 0 0 mirMAP -0.2 0.00043 NA
26 hsa-miR-374b-5p ABR 0 0 0 0 miRNATAP -0.11 1.0E-5 NA
27 hsa-miR-128-3p ACADM 0 0 0 0 miRNAWalker2 validate -0.16 0 NA
28 hsa-miR-23a-3p ACADSB 0 0 0 0 mirMAP -0.47 0 NA
29 hsa-miR-361-5p ACADSB 0 0 0 0 MirTarget; miRanda; miRNATAP -0.46 0 NA
30 hsa-miR-361-5p ACAP2 0 0 0 0 miRanda; mirMAP; miRNATAP -0.2 0 NA
31 hsa-miR-542-3p ACAT1 0 0 0 0 miRanda -0.16 0 NA
32 hsa-miR-361-5p ACBD5 0 0 0 0 miRanda -0.24 0 NA
33 hsa-miR-361-5p ACER3 0 0 0 0 mirMAP -0.24 0.0002 NA
34 hsa-miR-542-3p ACER3 0 0 0 0 miRanda -0.13 5.0E-5 NA
35 hsa-miR-361-5p ACLY 0 0 0 0 miRNAWalker2 validate; miRanda -0.29 0 NA
36 hsa-miR-374a-5p ACLY 0 0 0 0 mirMAP -0.22 0 NA
37 hsa-miR-542-3p ACSL1 0 0 0 0 miRanda -0.14 0.0041 NA
38 hsa-miR-223-3p ACSL3 0 0 0 0 MirTarget -0.14 0 NA
39 hsa-miR-128-3p ACSL5 0 0 0 0 miRNAWalker2 validate -0.2 5.0E-5 NA
40 hsa-miR-224-5p ACSS1 0 0 0 0 MirTarget -0.16 0 NA
41 hsa-miR-23a-3p ACSS1 0 0 0 0 MirTarget -0.49 0 NA
42 hsa-miR-23b-3p ACSS1 0 0 0 0 MirTarget -0.2 0 NA
43 hsa-miR-452-5p ACSS1 0 0 0 0 MirTarget -0.16 0 NA
44 hsa-miR-450b-5p ACTC1 0 0 0 0 mirMAP -0.14 0.04877 NA
45 hsa-miR-145-5p ACTG1 0 0 0 0 MirTarget; miRNATAP -0.12 0 NA
46 hsa-miR-128-3p ACVR2A 0 0 0 0 MirTarget -0.22 0 NA
47 hsa-miR-374a-5p ACVR2B 0 0 0 0 MirTarget -0.17 0 NA
48 hsa-miR-374b-5p ACVR2B 0 0 0 0 MirTarget -0.12 0.00069 NA
49 hsa-miR-361-5p ADAL 0 0 0 0 miRanda -0.16 0.00036 NA
50 hsa-miR-128-3p ADAM10 0 0 0 0 MirTarget -0.23 0 NA
51 hsa-miR-361-5p ADAM10 0 0 0 0 miRanda -0.51 0 NA
52 hsa-miR-374a-5p ADAM10 0 0 0 0 MirTarget; mirMAP -0.19 2.0E-5 NA
53 hsa-miR-361-5p ADAM12 0 0 0 0 miRanda -0.54 0 NA
54 hsa-miR-374a-5p ADAM12 0 0 0 0 mirMAP -0.23 0.00125 NA
55 hsa-miR-374b-5p ADAM12 0 0 0 0 mirMAP -0.22 0.00216 NA
56 hsa-miR-145-5p ADAM19 0 0 0 0 MirTarget; miRNATAP -0.15 0 26823772 MiR 145 suppressed human retinoblastoma cell proliferation and invasion by targeting ADAM19; ADAM19 was identified as a direct target of miR-145; In addition a reverse correlation between miR-145 and ADAM19 expression was noted in RB tissues
57 hsa-miR-361-5p ADAM19 0 0 0 0 miRanda -0.25 0.0017 NA
58 hsa-miR-361-5p ADAM22 0 0 0 0 mirMAP -0.33 0.0048 NA
59 hsa-miR-339-5p ADAM33 0 0 0 0 miRanda -0.39 0 NA
60 hsa-miR-339-5p ADAMTS13 0 0 0 0 mirMAP -0.13 0.00176 NA
61 hsa-miR-142-3p ADAMTS19 0 0 0 0 miRanda -0.19 0.00145 NA
62 hsa-miR-374b-5p ADAMTS19 0 0 0 0 mirMAP -0.53 9.0E-5 NA
63 hsa-miR-142-3p ADAMTS5 0 0 0 0 PITA; miRanda -0.2 0 NA
64 hsa-miR-339-5p ADAMTS7 0 0 0 0 miRanda -0.19 0 NA
65 hsa-miR-542-3p ADAMTSL3 0 0 0 0 miRanda -0.2 8.0E-5 NA
66 hsa-miR-223-3p ADCY1 0 0 0 0 mirMAP -0.38 0 NA
67 hsa-miR-23a-3p ADCY1 0 0 0 0 MirTarget -0.62 0 NA
68 hsa-miR-23b-3p ADCY1 0 0 0 0 MirTarget -0.23 0.00516 NA
69 hsa-miR-128-3p ADCY2 0 0 0 0 MirTarget -0.29 0.00151 NA
70 hsa-miR-493-5p ADCY6 0 0 0 0 miRNATAP -0.12 0 NA
71 hsa-miR-361-5p ADCY9 0 0 0 0 miRanda -0.25 2.0E-5 NA
72 hsa-miR-374a-5p ADCY9 0 0 0 0 mirMAP -0.34 0 NA
73 hsa-miR-374b-5p ADCY9 0 0 0 0 mirMAP -0.32 0 NA
74 hsa-miR-23a-3p ADH1B 0 0 0 0 mirMAP -0.72 0.00069 NA
75 hsa-miR-339-5p ADIPOQ 0 0 0 0 miRanda -0.33 0.03308 NA
76 hsa-miR-218-5p ADIPOR2 0 0 0 0 MirTarget; miRNATAP -0.15 0 NA
77 hsa-miR-145-5p ADM2 0 0 0 0 mirMAP -0.43 0 NA
78 hsa-miR-223-3p ADM2 0 0 0 0 mirMAP -0.16 8.0E-5 NA
79 hsa-miR-378a-3p ADM2 0 0 0 0 mirMAP -0.2 0 NA
80 hsa-miR-361-5p ADNP 0 0 0 0 miRanda -0.31 0 NA
81 hsa-miR-374a-5p ADNP 0 0 0 0 mirMAP -0.16 0 NA
82 hsa-miR-542-3p ADNP 0 0 0 0 miRanda -0.12 0 NA
83 hsa-miR-339-5p ADORA2A 0 0 0 0 miRanda; miRNATAP -0.18 0.0004 NA
84 hsa-miR-339-5p ADRA2A 0 0 0 0 miRanda -0.16 0.00331 NA
85 hsa-miR-142-3p ADRA2C 0 0 0 0 miRanda -0.3 0 NA
86 hsa-miR-361-5p ADSS 0 0 0 0 miRanda -0.2 0 NA
87 hsa-miR-542-3p AEBP2 0 0 0 0 miRanda -0.12 0 NA
88 hsa-miR-374a-5p AFF1 0 0 0 0 MirTarget -0.12 0.00119 NA
89 hsa-miR-374b-5p AFF1 0 0 0 0 MirTarget -0.1 0.00676 NA
90 hsa-miR-128-3p AFF3 0 0 0 0 MirTarget -0.83 0 NA
91 hsa-miR-224-5p AFF3 0 0 0 0 MirTarget -0.49 0 NA
92 hsa-miR-374a-5p AFF3 0 0 0 0 mirMAP -0.55 1.0E-5 NA
93 hsa-miR-374b-5p AFF3 0 0 0 0 mirMAP -0.59 0 NA
94 hsa-miR-128-3p AFF4 0 0 0 0 miRNAWalker2 validate; MirTarget -0.26 0 NA
95 hsa-miR-361-5p AFF4 0 0 0 0 miRanda -0.48 0 NA
96 hsa-miR-374a-5p AFF4 0 0 0 0 MirTarget; miRNATAP -0.28 0 NA
97 hsa-miR-374b-5p AFF4 0 0 0 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.22 0 NA
98 hsa-miR-542-3p AFF4 0 0 0 0 miRanda -0.13 0 NA
99 hsa-miR-374b-5p AFTPH 0 0 0 0 miRNAWalker2 validate -0.15 0 NA
100 hsa-miR-142-3p AGBL2 0 0 0 0 miRNAWalker2 validate -0.11 0.00077 NA
101 hsa-miR-217 AGBL4 0 0 0 0 miRanda -0.1 0.01418 NA
102 hsa-miR-224-5p AGBL4 0 0 0 0 mirMAP -0.2 0 NA
103 hsa-miR-374a-5p AGGF1 0 0 0 0 mirMAP -0.2 0 NA
104 hsa-miR-374b-5p AGGF1 0 0 0 0 mirMAP -0.15 0 NA
105 hsa-miR-361-5p AGL 0 0 0 0 miRanda -0.34 2.0E-5 NA
106 hsa-miR-361-5p AGPS 0 0 0 0 miRanda; miRNATAP -0.36 0 NA
107 hsa-miR-361-5p AGR2 0 0 0 0 miRanda -1.31 0 NA
108 hsa-miR-542-3p AHCYL1 0 0 0 0 miRanda -0.15 0 NA
109 hsa-miR-361-5p AHCYL2 0 0 0 0 miRanda -0.33 0 NA
110 hsa-miR-361-5p AHI1 0 0 0 0 miRanda -0.17 0.00018 NA
111 hsa-miR-361-5p AHNAK 0 0 0 0 miRanda -0.44 0 NA
112 hsa-miR-542-3p AIDA 0 0 0 0 miRanda -0.1 0 NA
113 hsa-miR-145-5p AIFM1 0 0 0 0 miRNATAP -0.13 0 20332243 Artificial overexpression of miR145 by using adenoviral vectors in prostate cancer PC-3 and DU145 cells significantly downregulated BNIP3 together with the upregulation of AIF reduced cell growth and increased cell death
114 hsa-miR-128-3p AIG1 0 0 0 0 MirTarget -0.16 0 NA
115 hsa-miR-142-3p AK5 0 0 0 0 miRanda -0.43 0 NA
116 hsa-miR-339-5p AK5 0 0 0 0 miRanda -0.37 1.0E-5 NA
117 hsa-miR-493-5p AKAP1 0 0 0 0 miRNATAP -0.12 0 NA
118 hsa-miR-542-3p AKAP10 0 0 0 0 PITA; miRanda -0.15 0 NA
119 hsa-miR-361-5p AKAP11 0 0 0 0 mirMAP -0.41 0 NA
120 hsa-miR-542-3p AKAP11 0 0 0 0 miRNATAP -0.13 0 NA
121 hsa-miR-361-5p AKAP12 0 0 0 0 miRanda -0.26 0.01151 NA
122 hsa-miR-339-5p AKAP13 0 0 0 0 miRanda -0.1 0 NA
123 hsa-miR-361-5p AKAP5 0 0 0 0 miRanda -0.57 0 NA
124 hsa-miR-339-5p AKNA 0 0 0 0 miRanda -0.1 0.00023 NA
125 hsa-miR-361-5p AKR1B10 0 0 0 0 miRanda -0.76 5.0E-5 NA
126 hsa-miR-142-3p AKR7L 0 0 0 0 miRanda -0.17 0 NA
127 hsa-miR-143-3p AKT1 0 0 0 0 miRNAWalker2 validate -0.11 0 NA
128 hsa-miR-142-3p ALAD 0 0 0 0 miRNAWalker2 validate -0.11 0 NA
129 hsa-miR-339-5p ALB 0 0 0 0 miRanda -0.27 0.01599 NA
130 hsa-miR-223-3p ALCAM 0 0 0 0 MirTarget -0.29 0 NA
131 hsa-miR-361-5p ALCAM 0 0 0 0 miRanda -0.58 0 NA
132 hsa-miR-339-5p ALDH16A1 0 0 0 0 miRanda -0.13 3.0E-5 NA
133 hsa-miR-142-3p ALDH1A2 0 0 0 0 PITA; miRanda -0.24 0 NA
134 hsa-miR-361-5p ALDH1L2 0 0 0 0 miRanda; mirMAP; miRNATAP -0.34 6.0E-5 NA
135 hsa-miR-128-3p ALDH4A1 0 0 0 0 miRNAWalker2 validate -0.11 0.01065 NA
136 hsa-miR-361-5p ALDH6A1 0 0 0 0 miRanda; miRNATAP -0.49 0 NA
137 hsa-miR-23b-3p ALDOA 0 0 0 0 miRNAWalker2 validate -0.13 0.00024 NA
138 hsa-miR-542-3p ALG10B 0 0 0 0 PITA; miRanda -0.14 0 NA
139 hsa-miR-23a-3p ALG13 0 0 0 0 MirTarget -0.12 0 NA
140 hsa-miR-361-5p ALG9 0 0 0 0 miRanda -0.17 0 NA
141 hsa-miR-361-5p ALKBH8 0 0 0 0 miRanda -0.3 0 NA
142 hsa-miR-542-3p ALPK3 0 0 0 0 mirMAP -0.11 0.00294 NA
143 hsa-miR-629-5p ALPK3 0 0 0 0 mirMAP -0.12 0.00612 NA
144 hsa-miR-629-5p ALS2CL 0 0 0 0 MirTarget -0.33 0 NA
145 hsa-miR-339-5p AMBP 0 0 0 0 miRanda -0.24 0.00491 NA
146 hsa-miR-361-5p AMFR 0 0 0 0 miRanda -0.27 0 NA
147 hsa-miR-450b-5p AMIGO1 0 0 0 0 mirMAP -0.17 0 NA
148 hsa-miR-361-5p AMIGO2 0 0 0 0 miRanda -0.3 0.00637 NA
149 hsa-miR-143-3p AMMECR1 0 0 0 0 miRNATAP -0.11 0.00012 NA
150 hsa-miR-224-5p AMN1 0 0 0 0 MirTarget -0.11 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 NEUROGENESIS 355 1402 2.564e-20 1.193e-16
2 RESPONSE TO ENDOGENOUS STIMULUS 348 1450 4.232e-16 5.867e-13
3 PROTEIN LOCALIZATION 416 1805 5.043e-16 5.867e-13
4 REGULATION OF TRANSPORT 417 1804 2.764e-16 5.867e-13
5 CELL DEVELOPMENT 339 1426 4.462e-15 4.153e-12
6 POSITIVE REGULATION OF GENE EXPRESSION 396 1733 1.161e-14 9.002e-12
7 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 380 1656 2.282e-14 1.18e-11
8 CARDIOVASCULAR SYSTEM DEVELOPMENT 209 788 2.029e-14 1.18e-11
9 CIRCULATORY SYSTEM DEVELOPMENT 209 788 2.029e-14 1.18e-11
10 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 382 1672 3.796e-14 1.766e-11
11 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 437 1977 1.108e-13 4.383e-11
12 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 251 1008 1.13e-13 4.383e-11
13 POSITIVE REGULATION OF MOLECULAR FUNCTION 402 1791 1.227e-13 4.39e-11
14 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 239 957 3.272e-13 1.015e-10
15 POSITIVE REGULATION OF CELL COMMUNICATION 351 1532 3.229e-13 1.015e-10
16 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 402 1805 4.094e-13 1.191e-10
17 REGULATION OF CELLULAR LOCALIZATION 301 1277 5.526e-13 1.512e-10
18 VASCULATURE DEVELOPMENT 136 469 9.142e-13 2.363e-10
19 CELL PROJECTION ORGANIZATION 225 902 1.91e-12 4.678e-10
20 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 274 1152 2.313e-12 5.381e-10
21 REGULATION OF PROTEIN LOCALIZATION 234 950 2.673e-12 5.654e-10
22 REGULATION OF CELLULAR COMPONENT MOVEMENT 198 771 2.658e-12 5.654e-10
23 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 181 689 2.989e-12 5.863e-10
24 POSITIVE REGULATION OF TRANSPORT 231 936 3.024e-12 5.863e-10
25 RESPONSE TO HORMONE 222 893 3.861e-12 7.049e-10
26 PROTEIN PHOSPHORYLATION 232 944 4.242e-12 7.049e-10
27 TISSUE DEVELOPMENT 343 1518 4.138e-12 7.049e-10
28 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 393 1784 3.942e-12 7.049e-10
29 ESTABLISHMENT OF PROTEIN LOCALIZATION 323 1423 1.064e-11 1.65e-09
30 POSITIVE REGULATION OF CATALYTIC ACTIVITY 341 1518 1.045e-11 1.65e-09
31 INTRACELLULAR SIGNAL TRANSDUCTION 351 1572 1.124e-11 1.687e-09
32 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 191 750 1.446e-11 2.102e-09
33 REGULATION OF CELL PROJECTION ORGANIZATION 151 558 1.864e-11 2.628e-09
34 REGULATION OF NEURON DIFFERENTIATION 150 554 2.081e-11 2.848e-09
35 NEURON DIFFERENTIATION 215 874 2.463e-11 3.274e-09
36 CELLULAR RESPONSE TO HORMONE STIMULUS 149 552 3.109e-11 4.018e-09
37 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 243 1021 4.146e-11 5.213e-09
38 CELLULAR COMPONENT MORPHOGENESIS 219 900 4.715e-11 5.774e-09
39 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 314 1395 5.948e-11 7.096e-09
40 REGULATION OF CELL DIFFERENTIATION 332 1492 6.702e-11 7.796e-09
41 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 265 1142 8.652e-11 9.819e-09
42 REGULATION OF CELL DEVELOPMENT 205 836 9.858e-11 1.092e-08
43 NEGATIVE REGULATION OF CELL COMMUNICATION 273 1192 1.87e-10 2.024e-08
44 BLOOD VESSEL MORPHOGENESIS 106 364 2.284e-10 2.415e-08
45 PHOSPHORYLATION 279 1228 2.81e-10 2.906e-08
46 CELLULAR RESPONSE TO STRESS 342 1565 3.237e-10 3.274e-08
47 NEURON DEVELOPMENT 173 687 3.481e-10 3.447e-08
48 UROGENITAL SYSTEM DEVELOPMENT 91 299 3.568e-10 3.459e-08
49 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 134 498 3.868e-10 3.673e-08
50 NEURON PROJECTION DEVELOPMENT 143 545 6.535e-10 6.081e-08
51 REGULATION OF GTPASE ACTIVITY 169 673 7.012e-10 6.398e-08
52 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 208 873 1.022e-09 9.145e-08
53 POSITIVE REGULATION OF HYDROLASE ACTIVITY 214 905 1.161e-09 1.019e-07
54 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 233 1004 1.267e-09 1.092e-07
55 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 90 303 1.745e-09 1.476e-07
56 REGULATION OF PROTEIN MODIFICATION PROCESS 364 1710 2.222e-09 1.846e-07
57 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 84 278 2.464e-09 2.011e-07
58 HEAD DEVELOPMENT 174 709 2.514e-09 2.017e-07
59 CELLULAR MACROMOLECULE LOCALIZATION 275 1234 2.91e-09 2.295e-07
60 REGULATION OF NEURON PROJECTION DEVELOPMENT 112 408 3.159e-09 2.45e-07
61 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 118 437 3.454e-09 2.634e-07
62 CELL PART MORPHOGENESIS 158 633 3.98e-09 2.987e-07
63 VESICLE MEDIATED TRANSPORT 275 1239 4.4e-09 3.249e-07
64 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 387 1848 5.062e-09 3.68e-07
65 REGULATION OF CELLULAR COMPONENT BIOGENESIS 184 767 5.62e-09 4.023e-07
66 HEART DEVELOPMENT 123 466 7.043e-09 4.965e-07
67 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 280 1275 9.314e-09 6.469e-07
68 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 72 232 9.709e-09 6.644e-07
69 NEURON PROJECTION MORPHOGENESIS 109 402 1.065e-08 7.183e-07
70 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 66 207 1.217e-08 8.086e-07
71 PROTEIN CATABOLIC PROCESS 145 579 1.39e-08 9.108e-07
72 PROTEIN UBIQUITINATION 155 629 1.411e-08 9.12e-07
73 POSITIVE REGULATION OF NEURON DIFFERENTIATION 88 306 1.457e-08 9.285e-07
74 POSITIVE REGULATION OF CELL DEVELOPMENT 123 472 1.576e-08 9.912e-07
75 ANGIOGENESIS 85 293 1.645e-08 1.021e-06
76 REGULATION OF CELLULAR PROTEIN LOCALIZATION 139 552 1.926e-08 1.179e-06
77 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 173 724 2.179e-08 1.317e-06
78 REGULATION OF PHOSPHORUS METABOLIC PROCESS 341 1618 2.327e-08 1.388e-06
79 POSITIVE REGULATION OF CELL DIFFERENTIATION 192 823 2.524e-08 1.487e-06
80 REGULATION OF HYDROLASE ACTIVITY 287 1327 2.813e-08 1.636e-06
81 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 130 513 3.726e-08 2.14e-06
82 REGULATION OF ORGANELLE ORGANIZATION 258 1178 4.759e-08 2.701e-06
83 CENTRAL NERVOUS SYSTEM DEVELOPMENT 200 872 5.075e-08 2.845e-06
84 POSITIVE REGULATION OF RESPONSE TO STIMULUS 395 1929 5.264e-08 2.916e-06
85 RESPONSE TO STEROID HORMONE 126 497 5.867e-08 3.201e-06
86 ESTABLISHMENT OF LOCALIZATION IN CELL 349 1676 5.915e-08 3.201e-06
87 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 69 229 7.18e-08 3.84e-06
88 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 99 368 7.552e-08 3.993e-06
89 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 185 799 8.064e-08 4.216e-06
90 MUSCLE STRUCTURE DEVELOPMENT 112 432 9.169e-08 4.741e-06
91 LOCOMOTION 244 1114 1.117e-07 5.71e-06
92 POSITIVE REGULATION OF LOCOMOTION 109 420 1.284e-07 6.496e-06
93 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 289 1360 1.395e-07 6.978e-06
94 RESPONSE TO ORGANIC CYCLIC COMPOUND 206 917 1.667e-07 8.253e-06
95 RESPONSE TO OXYGEN CONTAINING COMPOUND 292 1381 1.923e-07 9.418e-06
96 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 63 208 2.122e-07 1.028e-05
97 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 94 352 2.307e-07 1.106e-05
98 RESPONSE TO NITROGEN COMPOUND 194 859 2.598e-07 1.234e-05
99 REGULATION OF SYNAPTIC PLASTICITY 47 140 2.713e-07 1.262e-05
100 REGULATION OF INTRACELLULAR TRANSPORT 148 621 2.7e-07 1.262e-05
101 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 68 232 2.826e-07 1.302e-05
102 CELLULAR RESPONSE TO PEPTIDE 77 274 3.182e-07 1.452e-05
103 REGULATION OF VESICLE MEDIATED TRANSPORT 116 462 3.34e-07 1.509e-05
104 SINGLE ORGANISM BEHAVIOR 100 384 3.523e-07 1.576e-05
105 RESPONSE TO WOUNDING 136 563 3.678e-07 1.63e-05
106 CELLULAR RESPONSE TO INSULIN STIMULUS 48 146 4.126e-07 1.803e-05
107 REGULATION OF EPITHELIAL CELL PROLIFERATION 79 285 4.145e-07 1.803e-05
108 EMBRYONIC MORPHOGENESIS 131 539 4.21e-07 1.814e-05
109 EPITHELIUM DEVELOPMENT 209 945 4.535e-07 1.936e-05
110 REGULATION OF MEMBRANE POTENTIAL 91 343 4.881e-07 2.046e-05
111 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 104 406 4.87e-07 2.046e-05
112 CELLULAR RESPONSE TO OXYGEN LEVELS 47 143 5.474e-07 2.274e-05
113 REGULATION OF CELL MORPHOGENESIS 133 552 5.74e-07 2.364e-05
114 MUSCLE CELL DIFFERENTIATION 68 237 6.702e-07 2.736e-05
115 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 125 514 7.445e-07 3.012e-05
116 REGULATION OF SECRETION 161 699 7.907e-07 3.172e-05
117 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 56 184 8.254e-07 3.282e-05
118 MACROMOLECULE CATABOLIC PROCESS 204 926 8.325e-07 3.283e-05
119 REGULATION OF TRANSPORTER ACTIVITY 59 198 9.277e-07 3.628e-05
120 REGULATION OF CYTOPLASMIC TRANSPORT 118 481 9.476e-07 3.674e-05
121 TUBE DEVELOPMENT 132 552 9.765e-07 3.755e-05
122 MODULATION OF SYNAPTIC TRANSMISSION 81 301 1.104e-06 4.209e-05
123 RESPONSE TO LIPID 196 888 1.199e-06 4.536e-05
124 EPITHELIAL CELL DEVELOPMENT 56 186 1.209e-06 4.538e-05
125 EMBRYO DEVELOPMENT 197 894 1.265e-06 4.71e-05
126 CELLULAR CATABOLIC PROCESS 276 1322 1.293e-06 4.73e-05
127 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 93 360 1.301e-06 4.73e-05
128 STRIATED MUSCLE CELL DIFFERENTIATION 53 173 1.285e-06 4.73e-05
129 RESPONSE TO ABIOTIC STIMULUS 221 1024 1.411e-06 5.09e-05
130 CELLULAR RESPONSE TO NITROGEN COMPOUND 122 505 1.444e-06 5.168e-05
131 ENDOMEMBRANE SYSTEM ORGANIZATION 114 465 1.49e-06 5.254e-05
132 RESPONSE TO GROWTH FACTOR 116 475 1.484e-06 5.254e-05
133 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 129 541 1.516e-06 5.266e-05
134 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 129 541 1.516e-06 5.266e-05
135 REGULATION OF DEVELOPMENTAL GROWTH 78 289 1.53e-06 5.273e-05
136 REGULATION OF CELLULAR RESPONSE TO STRESS 158 691 1.581e-06 5.408e-05
137 DEVELOPMENTAL GROWTH 87 333 1.719e-06 5.801e-05
138 SINGLE ORGANISM CELLULAR LOCALIZATION 197 898 1.733e-06 5.801e-05
139 RENAL SYSTEM PROCESS 36 102 1.728e-06 5.801e-05
140 TISSUE MORPHOGENESIS 127 533 1.898e-06 6.308e-05
141 CATABOLIC PROCESS 356 1773 1.918e-06 6.329e-05
142 REGULATION OF GLUCOSE IMPORT 25 60 2.118e-06 6.94e-05
143 REGULATION OF METAL ION TRANSPORT 85 325 2.149e-06 6.994e-05
144 SECRETION BY CELL 117 486 2.821e-06 9.114e-05
145 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 87 337 2.904e-06 9.31e-05
146 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 166 740 2.921e-06 9.31e-05
147 STEROID HORMONE MEDIATED SIGNALING PATHWAY 41 125 2.992e-06 9.47e-05
148 REGULATION OF CELL CYCLE 205 949 3.208e-06 0.0001009
149 APPENDAGE DEVELOPMENT 51 169 3.291e-06 0.0001021
150 LIMB DEVELOPMENT 51 169 3.291e-06 0.0001021
151 REGULATION OF NEURON APOPTOTIC PROCESS 56 192 3.605e-06 0.0001111
152 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 177 801 3.673e-06 0.0001124
153 POST EMBRYONIC DEVELOPMENT 32 89 4.058e-06 0.0001234
154 REGULATION OF EPITHELIAL CELL MIGRATION 50 166 4.338e-06 0.0001311
155 WOUND HEALING 113 470 4.424e-06 0.0001328
156 GROWTH 101 410 4.633e-06 0.0001382
157 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 133 573 4.69e-06 0.000139
158 ACTION POTENTIAL 33 94 5.249e-06 0.0001546
159 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 307 1517 5.331e-06 0.0001558
160 NEGATIVE REGULATION OF MAPK CASCADE 45 145 5.392e-06 0.0001558
161 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 154 684 5.361e-06 0.0001558
162 PROTEOLYSIS 251 1208 5.779e-06 0.000166
163 COGNITION 68 251 6.061e-06 0.000173
164 NEGATIVE REGULATION OF CELL DEATH 189 872 6.257e-06 0.0001775
165 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 34 99 6.614e-06 0.0001854
166 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 34 99 6.614e-06 0.0001854
167 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 55 191 6.673e-06 0.0001859
168 NEURON PROJECTION GUIDANCE 58 205 6.897e-06 0.000191
169 ERBB SIGNALING PATHWAY 29 79 7.081e-06 0.0001949
170 SECRETION 135 588 7.205e-06 0.0001972
171 BEHAVIOR 121 516 7.466e-06 0.0002032
172 REGULATION OF BODY FLUID LEVELS 119 506 7.666e-06 0.0002074
173 MORPHOGENESIS OF AN EPITHELIUM 98 400 8.143e-06 0.000219
174 RESPONSE TO OXYGEN LEVELS 80 311 8.248e-06 0.0002206
175 POSITIVE REGULATION OF GLUCOSE TRANSPORT 19 42 8.322e-06 0.0002213
176 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 301 1492 8.615e-06 0.0002265
177 REGULATION OF CYTOSKELETON ORGANIZATION 118 502 8.567e-06 0.0002265
178 POSITIVE REGULATION OF GLYCOGEN METABOLIC PROCESS 11 17 8.871e-06 0.0002319
179 INSULIN RECEPTOR SIGNALING PATHWAY 29 80 9.411e-06 0.0002446
180 CELLULAR RESPONSE TO LIPID 109 457 9.473e-06 0.0002449
181 CELL MOTILITY 181 835 9.75e-06 0.0002493
182 LOCALIZATION OF CELL 181 835 9.75e-06 0.0002493
183 NEGATIVE REGULATION OF PHOSPHORYLATION 102 422 9.983e-06 0.0002538
184 RESPONSE TO OXIDATIVE STRESS 88 352 1.009e-05 0.0002552
185 TUBE MORPHOGENESIS 82 323 1.088e-05 0.0002736
186 RESPONSE TO INORGANIC SUBSTANCE 113 479 1.111e-05 0.000278
187 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 208 983 1.13e-05 0.0002811
188 NEGATIVE REGULATION OF GENE EXPRESSION 300 1493 1.242e-05 0.0003041
189 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 60 218 1.233e-05 0.0003041
190 POSITIVE REGULATION OF SYNAPTIC TRANSMISSION 36 110 1.238e-05 0.0003041
191 MULTICELLULAR ORGANISMAL SIGNALING 39 123 1.273e-05 0.0003101
192 REGULATION OF FAT CELL DIFFERENTIATION 35 106 1.307e-05 0.0003169
193 CELL CYCLE 268 1316 1.354e-05 0.0003264
194 POSITIVE REGULATION OF CATABOLIC PROCESS 96 395 1.421e-05 0.0003407
195 RESPONSE TO INSULIN 57 205 1.451e-05 0.0003444
196 NEGATIVE REGULATION OF JNK CASCADE 16 33 1.451e-05 0.0003444
197 ORGAN MORPHOGENESIS 181 841 1.516e-05 0.0003561
198 RESPONSE TO DRUG 103 431 1.51e-05 0.0003561
199 REGULATION OF TRANSMEMBRANE TRANSPORT 102 426 1.523e-05 0.0003561
200 REGULATION OF CELL MATRIX ADHESION 31 90 1.553e-05 0.0003612
201 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 104 437 1.659e-05 0.0003839
202 MEMBRANE BIOGENESIS 15 30 1.681e-05 0.0003871
203 EPITHELIAL CELL DIFFERENTIATION 115 495 1.935e-05 0.0004435
204 INTRACELLULAR PROTEIN TRANSPORT 169 781 2.117e-05 0.0004828
205 REGULATION OF KINASE ACTIVITY 168 776 2.176e-05 0.0004901
206 SKELETAL SYSTEM DEVELOPMENT 107 455 2.167e-05 0.0004901
207 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE 20 48 2.18e-05 0.0004901
208 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 33 100 2.313e-05 0.0005173
209 CAMP METABOLIC PROCESS 16 34 2.331e-05 0.000519
210 REGULATION OF CELL DEATH 294 1472 2.462e-05 0.0005455
211 RESPONSE TO ESTROGEN 59 218 2.499e-05 0.0005512
212 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 38 122 2.562e-05 0.0005623
213 PROTEIN DEPHOSPHORYLATION 53 190 2.583e-05 0.0005643
214 HORMONE MEDIATED SIGNALING PATHWAY 46 158 2.694e-05 0.0005858
215 GOLGI ORGANIZATION 29 84 2.746e-05 0.0005915
216 POSITIVE REGULATION OF OSSIFICATION 29 84 2.746e-05 0.0005915
217 REGULATION OF CATABOLIC PROCESS 159 731 2.776e-05 0.0005952
218 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 68 262 2.792e-05 0.0005959
219 REGULATION OF MITOTIC CELL CYCLE 109 468 2.82e-05 0.0005991
220 SYNAPSE ORGANIZATION 43 145 2.988e-05 0.000632
221 FOREBRAIN DEVELOPMENT 87 357 3.154e-05 0.000664
222 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 108 465 3.463e-05 0.0007259
223 PROTEIN AUTOPHOSPHORYLATION 53 192 3.531e-05 0.0007367
224 REGULATION OF CELL PROLIFERATION 297 1496 3.581e-05 0.0007439
225 RESPONSE TO PEPTIDE 96 404 3.666e-05 0.0007548
226 REGULATION OF GLYCOGEN METABOLIC PROCESS 16 35 3.654e-05 0.0007548
227 REGULATION OF MAPK CASCADE 145 660 3.704e-05 0.0007592
228 REGULATION OF BMP SIGNALING PATHWAY 27 77 3.75e-05 0.0007653
229 REGULATION OF PLASMA MEMBRANE ORGANIZATION 26 73 3.814e-05 0.000775
230 MEMORY 32 98 3.871e-05 0.000783
231 REGULATION OF ANATOMICAL STRUCTURE SIZE 109 472 4.112e-05 0.0008283
232 SENSORY ORGAN DEVELOPMENT 113 493 4.204e-05 0.0008431
233 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 89 370 4.315e-05 0.0008618
234 NEGATIVE REGULATION OF CELL DIFFERENTIATION 135 609 4.38e-05 0.000871
235 ERBB2 SIGNALING PATHWAY 17 39 4.47e-05 0.0008851
236 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORT 36 116 4.501e-05 0.0008875
237 BIOLOGICAL ADHESION 213 1032 4.578e-05 0.0008989
238 KIDNEY EPITHELIUM DEVELOPMENT 38 125 4.66e-05 0.000911
239 WNT SIGNALING PATHWAY 85 351 4.916e-05 0.000957
240 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 136 616 5.02e-05 0.0009733
241 PEPTIDYL SERINE MODIFICATION 43 148 5.113e-05 0.0009871
242 REGULATION OF LIPID METABOLIC PROCESS 71 282 5.453e-05 0.001048
243 REGULATION OF ACTIN FILAMENT BASED PROCESS 77 312 5.588e-05 0.00107
244 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 42 144 5.632e-05 0.001074
245 REGULATION OF SYSTEM PROCESS 115 507 5.78e-05 0.001098
246 MEMBRANE ORGANIZATION 188 899 5.988e-05 0.001133
247 RESPONSE TO METAL ION 81 333 6.214e-05 0.001171
248 EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 21 55 6.498e-05 0.001219
249 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 9 14 6.622e-05 0.001238
250 REGULATION OF AXONOGENESIS 47 168 6.651e-05 0.001238
251 PROTEIN LOCALIZATION TO ORGANELLE 124 556 6.686e-05 0.001239
252 CELL PROJECTION ASSEMBLY 67 264 6.72e-05 0.001241
253 EMBRYONIC AXIS SPECIFICATION 15 33 6.937e-05 0.001276
254 PROTEIN COMPLEX SUBUNIT ORGANIZATION 300 1527 7.283e-05 0.001334
255 PROTEIN K48 LINKED DEUBIQUITINATION 11 20 7.502e-05 0.001369
256 NEURON MIGRATION 34 110 7.912e-05 0.001438
257 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 42 146 7.973e-05 0.001444
258 CYTOSKELETON ORGANIZATION 176 838 8.063e-05 0.001454
259 CIRCULATORY SYSTEM PROCESS 87 366 8.189e-05 0.001471
260 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO CELL PERIPHERY 16 37 8.395e-05 0.001491
261 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE 16 37 8.395e-05 0.001491
262 NEGATIVE REGULATION OF CELL CYCLE 100 433 8.35e-05 0.001491
263 NEURON MATURATION 14 30 8.48e-05 0.0015
264 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 123 554 8.756e-05 0.001539
265 DEPHOSPHORYLATION 71 286 8.766e-05 0.001539
266 PROTEIN COMPLEX BIOGENESIS 229 1132 8.932e-05 0.001557
267 PROTEIN COMPLEX ASSEMBLY 229 1132 8.932e-05 0.001557
268 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 17 41 9.612e-05 0.001646
269 NEGATIVE REGULATION OF STRESS ACTIVATED MAPK CASCADE 17 41 9.612e-05 0.001646
270 REGULATION OF HORMONE SECRETION 66 262 9.619e-05 0.001646
271 NEGATIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 17 41 9.612e-05 0.001646
272 CELL CYCLE CHECKPOINT 52 194 9.615e-05 0.001646
273 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 70 282 9.821e-05 0.001668
274 PEPTIDYL AMINO ACID MODIFICATION 176 841 9.815e-05 0.001668
275 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 53 199 9.926e-05 0.001678
276 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 31 98 9.955e-05 0.001678
277 POSITIVE REGULATION OF CELL PROLIFERATION 171 814 0.0001001 0.001681
278 METANEPHROS DEVELOPMENT 27 81 0.000102 0.001708
279 REGULATION OF NEUROTRANSMITTER LEVELS 51 190 0.0001074 0.001785
280 NEGATIVE REGULATION OF CELL CYCLE PROCESS 56 214 0.0001074 0.001785
281 NEGATIVE REGULATION OF CELL DEVELOPMENT 74 303 0.0001101 0.001823
282 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 19 49 0.0001124 0.001855
283 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 32 103 0.0001137 0.001869
284 IONOTROPIC GLUTAMATE RECEPTOR SIGNALING PATHWAY 12 24 0.0001192 0.001952
285 REGULATION OF EXOCYTOSIS 50 186 0.0001199 0.001957
286 ACTIVATION OF PROTEIN KINASE ACTIVITY 69 279 0.0001235 0.00201
287 RESPONSE TO UV 37 126 0.0001299 0.002106
288 AUTONOMIC NERVOUS SYSTEM DEVELOPMENT 17 42 0.0001374 0.00222
289 CHEMICAL HOMEOSTASIS 181 874 0.0001402 0.002254
290 CELL DEATH 204 1001 0.0001405 0.002254
291 SIGNAL RELEASE 47 173 0.0001438 0.002284
292 REGULATION OF CELL SUBSTRATE ADHESION 47 173 0.0001438 0.002284
293 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 228 1135 0.0001437 0.002284
294 RESPONSE TO RADIATION 95 413 0.0001445 0.002287
295 RESPIRATORY SYSTEM DEVELOPMENT 52 197 0.0001467 0.002314
296 PEPTIDYL THREONINE MODIFICATION 18 46 0.0001476 0.00232
297 POSITIVE REGULATION OF ION TRANSPORT 60 236 0.0001487 0.002324
298 EYE DEVELOPMENT 78 326 0.0001489 0.002324
299 REGULATION OF OSSIFICATION 48 178 0.0001494 0.002325
300 REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 19 50 0.0001541 0.002391
301 NEGATIVE REGULATION OF SYNAPTIC TRANSMISSION 22 62 0.0001566 0.002421
302 RESPONSE TO IRON ION 15 35 0.0001576 0.002428
303 POSITIVE REGULATION OF KINASE ACTIVITY 108 482 0.0001585 0.002434
304 ESTABLISHMENT OR MAINTENANCE OF CELL POLARITY 40 141 0.0001618 0.002475
305 REGULATION OF POTASSIUM ION TRANSPORT 27 83 0.0001622 0.002475
306 GLYCOPROTEIN METABOLIC PROCESS 83 353 0.0001732 0.002634
307 REGULATION OF HORMONE LEVELS 107 478 0.0001763 0.002672
308 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 16 39 0.0001782 0.002676
309 LONG TERM SYNAPTIC POTENTIATION 16 39 0.0001782 0.002676
310 CELLULAR RESPONSE TO OXIDATIVE STRESS 49 184 0.0001783 0.002676
311 REGULATION OF CELL CYCLE PROCESS 122 558 0.0001833 0.002743
312 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 37 128 0.0001849 0.002749
313 MUSCLE CELL DEVELOPMENT 37 128 0.0001849 0.002749
314 TELENCEPHALON DEVELOPMENT 58 228 0.0001867 0.002767
315 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 59 233 0.0001887 0.002778
316 CONNECTIVE TISSUE DEVELOPMENT 51 194 0.0001883 0.002778
317 INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY 24 71 0.0001904 0.002781
318 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 43 156 0.0001907 0.002781
319 POSITIVE REGULATION OF GROWTH 60 238 0.0001904 0.002781
320 PROTEIN POLYUBIQUITINATION 61 243 0.0001918 0.002788
321 MEMBRANE ASSEMBLY 12 25 0.0001957 0.002836
322 REGULATION OF CALCIUM ION TRANSPORT 54 209 0.0002004 0.002896
323 FAT CELL DIFFERENTIATION 32 106 0.000206 0.002967
324 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 34 115 0.0002069 0.002971
325 STEM CELL DIFFERENTIATION 50 190 0.0002107 0.003016
326 ION HOMEOSTASIS 125 576 0.000213 0.00304
327 EAR DEVELOPMENT 51 195 0.0002157 0.003062
328 CELL CYCLE PROCESS 217 1081 0.0002158 0.003062
329 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 218 1087 0.0002207 0.003121
330 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 31 102 0.0002248 0.00317
331 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 33 111 0.0002272 0.003193
332 PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 38 134 0.0002347 0.003279
333 REGULATION OF GENERATION OF PRECURSOR METABOLITES AND ENERGY 28 89 0.0002343 0.003279
334 RESPONSE TO NUTRIENT 50 191 0.0002415 0.003354
335 RESPONSE TO REACTIVE OXYGEN SPECIES 50 191 0.0002415 0.003354
336 MUSCLE TISSUE DEVELOPMENT 67 275 0.0002437 0.003371
337 NEGATIVE REGULATION OF KINASE ACTIVITY 62 250 0.0002441 0.003371
338 HOMEOSTATIC PROCESS 262 1337 0.0002487 0.003424
339 REGULATION OF ION HOMEOSTASIS 52 201 0.0002514 0.003451
340 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 16 40 0.0002529 0.00346
341 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 23 68 0.0002543 0.00346
342 NEGATIVE REGULATION OF CELL PROLIFERATION 137 643 0.0002537 0.00346
343 REGULATION OF LONG TERM SYNAPTIC POTENTIATION 10 19 0.0002605 0.003534
344 RESPONSE TO KETONE 48 182 0.0002637 0.003567
345 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 35 121 0.0002684 0.003599
346 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 35 121 0.0002684 0.003599
347 GDP METABOLIC PROCESS 8 13 0.0002679 0.003599
348 RESPONSE TO GLUCAGON 18 48 0.0002769 0.003701
349 REGULATION OF PROTEIN SECRETION 89 389 0.0002784 0.003701
350 OUTFLOW TRACT MORPHOGENESIS 20 56 0.0002783 0.003701
351 CELL PROLIFERATION 142 672 0.0002891 0.003833
352 NEGATIVE REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 37 131 0.0003071 0.004052
353 REGULATION OF NEURON DEATH 62 252 0.0003074 0.004052
354 REGULATION OF ION TRANSPORT 127 592 0.0003135 0.004121
355 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 35 122 0.0003189 0.00418
356 GLIAL CELL DIFFERENTIATION 38 136 0.0003252 0.00425
357 CARDIAC MUSCLE CELL ACTION POTENTIAL 15 37 0.0003299 0.004288
358 NEGATIVE REGULATION OF EPITHELIAL CELL DIFFERENTIATION 15 37 0.0003299 0.004288
359 REGULATION OF BINDING 68 283 0.0003356 0.004344
360 CARDIAC CONDUCTION 26 82 0.0003361 0.004344
361 POSITIVE REGULATION OF BINDING 36 127 0.0003407 0.004391
362 REGULATION OF VASCULATURE DEVELOPMENT 58 233 0.0003428 0.004406
363 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 21 61 0.0003537 0.004497
364 REGULATION OF POTASSIUM ION TRANSMEMBRANE TRANSPORT 21 61 0.0003537 0.004497
365 GLUTAMATE RECEPTOR SIGNALING PATHWAY 16 41 0.0003533 0.004497
366 ANDROGEN RECEPTOR SIGNALING PATHWAY 16 41 0.0003533 0.004497
367 RESPONSE TO ESTRADIOL 40 146 0.0003586 0.004527
368 REGULATION OF GLUCOSE TRANSPORT 30 100 0.0003609 0.004527
369 DNA INTEGRITY CHECKPOINT 40 146 0.0003586 0.004527
370 REGULATION OF RHO PROTEIN SIGNAL TRANSDUCTION 32 109 0.0003601 0.004527
371 PEPTIDYL TYROSINE DEPHOSPHORYLATION 30 100 0.0003609 0.004527
372 SPROUTING ANGIOGENESIS 17 45 0.000367 0.004591
373 POSITIVE REGULATION OF PHOSPHOLIPASE ACTIVITY 19 53 0.0003711 0.004629
374 REPRODUCTIVE SYSTEM DEVELOPMENT 92 408 0.0003739 0.004629
375 REGULATION OF PEPTIDE SECRETION 53 209 0.000374 0.004629
376 CARDIAC CELL DEVELOPMENT 18 49 0.0003725 0.004629
377 POSITIVE REGULATION OF SMOOTH MUSCLE CELL MIGRATION 13 30 0.0003775 0.004654
378 CELLULAR HOMEOSTASIS 142 676 0.0003781 0.004654
379 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 24 74 0.0003855 0.004733
380 EXOCYTOSIS 73 310 0.0003929 0.004811
381 CARDIOCYTE DIFFERENTIATION 29 96 0.0003949 0.004823
382 REGULATION OF BLOOD CIRCULATION 70 295 0.0004063 0.004949
383 RESPONSE TO ALCOHOL 83 362 0.0004081 0.004958
384 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 23 70 0.0004099 0.004967
385 REGULATION OF RESPONSE TO STRESS 283 1468 0.0004252 0.005139
386 RENAL WATER HOMEOSTASIS 14 34 0.0004289 0.00517
387 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 22 66 0.0004332 0.005177
388 CELLULAR RESPONSE TO UV 22 66 0.0004332 0.005177
389 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 22 66 0.0004332 0.005177
390 HEMOSTASIS 73 311 0.0004339 0.005177
391 REGULATION OF CELLULAR COMPONENT SIZE 78 337 0.0004444 0.005289
392 INOSITOL LIPID MEDIATED SIGNALING 35 124 0.000446 0.005294
393 DENDRITE DEVELOPMENT 25 79 0.0004481 0.005305
394 POSITIVE REGULATION OF POTASSIUM ION TRANSPORT 15 38 0.0004646 0.005473
395 ENDOPLASMIC RETICULUM ORGANIZATION 15 38 0.0004646 0.005473
396 EMBRYONIC PATTERN SPECIFICATION 20 58 0.000473 0.005558
397 TRANSITION METAL ION HOMEOSTASIS 31 106 0.0004749 0.005566
398 ARTERY DEVELOPMENT 24 75 0.0004815 0.005615
399 POSITIVE REGULATION OF AUTOPHAGY 24 75 0.0004815 0.005615
400 RESPONSE TO TRANSITION METAL NANOPARTICLE 40 148 0.0004843 0.005633
401 METAL ION TRANSPORT 124 582 0.000487 0.005638
402 REGULATION OF LYMPHOCYTE APOPTOTIC PROCESS 19 54 0.0004871 0.005638
403 REGULATION OF COENZYME METABOLIC PROCESS 18 50 0.0004953 0.005676
404 REGULATION OF COFACTOR METABOLIC PROCESS 18 50 0.0004953 0.005676
405 EMBRYONIC ORGAN DEVELOPMENT 91 406 0.000494 0.005676
406 REGULATION OF DENDRITE DEVELOPMENT 34 120 0.000495 0.005676
407 NUCLEOSIDE DIPHOSPHATE METABOLIC PROCESS 26 84 0.0005106 0.005838
408 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 103 470 0.0005136 0.005857
409 CAMP CATABOLIC PROCESS 8 14 0.0005367 0.006106
410 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 86 381 0.0005501 0.006228
411 CYTOSKELETON DEPENDENT INTRACELLULAR TRANSPORT 33 116 0.0005492 0.006228
412 REGULATION OF GROWTH 133 633 0.0005642 0.006372
413 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 37 135 0.0005796 0.006514
414 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 41 154 0.0005789 0.006514
415 MITOTIC CELL CYCLE 157 766 0.0006142 0.006887
416 HEART PROCESS 26 85 0.0006245 0.006985
417 PROTEIN MONOUBIQUITINATION 18 51 0.0006515 0.007269
418 REGULATION OF POLYSACCHARIDE METABOLIC PROCESS 16 43 0.0006597 0.007343
419 MACROMOLECULAR COMPLEX ASSEMBLY 269 1398 0.0006613 0.007344
420 ORGANELLE ASSEMBLY 107 495 0.0006771 0.007501
421 NERVE DEVELOPMENT 22 68 0.0006887 0.007611
422 RESPONSE TO LIGHT STIMULUS 66 280 0.0007053 0.007776
423 NEGATIVE REGULATION OF DENDRITE DEVELOPMENT 12 28 0.0007135 0.00783
424 MORPHOGENESIS OF A POLARIZED EPITHELIUM 12 28 0.0007135 0.00783
425 CHROMATIN MODIFICATION 115 539 0.0007246 0.007933
426 SYMPATHETIC NERVOUS SYSTEM DEVELOPMENT 10 21 0.0007291 0.007964
427 CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES 30 104 0.0007466 0.008135
428 MICROTUBULE CYTOSKELETON ORGANIZATION 79 348 0.0007565 0.008224
429 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 148 720 0.0007649 0.008296
430 CHONDROCYTE DIFFERENTIATION 20 60 0.0007764 0.008401
431 POSITIVE REGULATION OF LIPID KINASE ACTIVITY 13 32 0.0007979 0.008574
432 POSITIVE REGULATION OF BMP SIGNALING PATHWAY 13 32 0.0007979 0.008574
433 ADIPOSE TISSUE DEVELOPMENT 13 32 0.0007979 0.008574
434 REGULATION OF PROTEIN COMPLEX ASSEMBLY 84 375 0.0008099 0.008683
435 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 19 56 0.0008153 0.008721
436 REGULATION OF PEPTIDE TRANSPORT 61 256 0.0008239 0.008793
437 ENSHEATHMENT OF NEURONS 27 91 0.0008377 0.008899
438 AXON ENSHEATHMENT 27 91 0.0008377 0.008899
439 REGULATION OF ENDOTHELIAL CELL MIGRATION 32 114 0.0008491 0.009
440 ACTIN FILAMENT BASED PROCESS 98 450 0.0008606 0.009081
441 SYNAPSE ASSEMBLY 22 69 0.0008593 0.009081
442 POSITIVE REGULATION OF SYNAPTIC TRANSMISSION GLUTAMATERGIC 9 18 0.000868 0.009117
443 UTERUS DEVELOPMENT 9 18 0.000868 0.009117
444 REGULATION OF LIPID KINASE ACTIVITY 17 48 0.000872 0.009138
445 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 36 133 0.0008754 0.009154
446 FORELIMB MORPHOGENESIS 15 40 0.000878 0.00916
447 REGULATION OF CELL DIVISION 64 272 0.0008832 0.009193
448 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 37 138 0.000907 0.009399
449 RHYTHMIC PROCESS 69 298 0.0009065 0.009399
450 CARBOHYDRATE DERIVATIVE METABOLIC PROCESS 206 1047 0.0009117 0.009427
451 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 204 1036 0.0009246 0.009477
452 REGULATION OF TRANSFERASE ACTIVITY 188 946 0.0009259 0.009477
453 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 44 172 0.0009247 0.009477
454 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 204 1036 0.0009246 0.009477
455 REGULATION OF MAP KINASE ACTIVITY 73 319 0.0009288 0.009477
456 GOLGI VESICLE TRANSPORT 73 319 0.0009288 0.009477
457 RAS PROTEIN SIGNAL TRANSDUCTION 38 143 0.0009356 0.009526
458 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 49 197 0.0009624 0.009777
459 MEMBRANE DEPOLARIZATION 20 61 0.0009826 0.009933
460 LONG TERM SYNAPTIC DEPRESSION 8 15 0.000988 0.009933
461 CELLULAR RESPONSE TO HYDROGEN PEROXIDE 20 61 0.0009826 0.009933
462 PALLIUM DEVELOPMENT 40 153 0.0009843 0.009933
463 DIVALENT INORGANIC CATION TRANSPORT 63 268 0.0009884 0.009933
NumGOOverlapSizeP ValueAdj. P Value
1 RIBONUCLEOTIDE BINDING 443 1860 8.465e-20 7.864e-17
2 ADENYL NUCLEOTIDE BINDING 367 1514 1.119e-17 5.196e-15
3 ENZYME BINDING 407 1737 6.472e-17 2.004e-14
4 KINASE ACTIVITY 219 842 4.27e-14 9.918e-12
5 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 246 992 3.262e-13 6.061e-11
6 PROTEIN KINASE ACTIVITY 168 640 1.97e-11 3.051e-09
7 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 278 1199 3.147e-11 4.176e-09
8 PROTEIN SERINE THREONINE KINASE ACTIVITY 125 445 7.764e-11 9.016e-09
9 REGULATORY REGION NUCLEIC ACID BINDING 201 818 1.252e-10 1.292e-08
10 MOLECULAR FUNCTION REGULATOR 300 1353 9.135e-10 8.487e-08
11 MACROMOLECULAR COMPLEX BINDING 306 1399 2.782e-09 2.349e-07
12 UBIQUITIN LIKE PROTEIN TRANSFERASE ACTIVITY 114 420 4.616e-09 3.574e-07
13 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 156 629 7.971e-09 5.696e-07
14 ZINC ION BINDING 257 1155 1.152e-08 7.647e-07
15 HYDROLASE ACTIVITY ACTING ON ACID ANHYDRIDES 192 820 1.889e-08 1.17e-06
16 TRANSITION METAL ION BINDING 299 1400 5.055e-08 2.935e-06
17 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 91 328 5.412e-08 2.958e-06
18 CHROMATIN BINDING 113 435 7.192e-08 3.712e-06
19 SEQUENCE SPECIFIC DNA BINDING 230 1037 9.272e-08 4.533e-06
20 PROTEIN DOMAIN SPECIFIC BINDING 149 624 2.176e-07 1.011e-05
21 NUCLEOSIDE TRIPHOSPHATASE REGULATOR ACTIVITY 89 329 2.592e-07 1.102e-05
22 LIGASE ACTIVITY 105 406 2.611e-07 1.102e-05
23 PROTEIN PHOSPHATASE BINDING 42 120 3.196e-07 1.26e-05
24 PHOSPHATASE BINDING 52 162 3.256e-07 1.26e-05
25 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 83 303 3.68e-07 1.367e-05
26 DOUBLE STRANDED DNA BINDING 174 764 6.159e-07 2.201e-05
27 CORE PROMOTER PROXIMAL REGION DNA BINDING 94 371 2.804e-06 9.649e-05
28 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 63 226 4.833e-06 0.0001603
29 UBIQUITIN LIKE PROTEIN LIGASE ACTIVITY 57 199 5.475e-06 0.0001754
30 IDENTICAL PROTEIN BINDING 251 1209 6.156e-06 0.0001906
31 CYTOSKELETAL PROTEIN BINDING 179 819 6.533e-06 0.0001958
32 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 81 315 7.37e-06 0.0002075
33 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 135 588 7.205e-06 0.0002075
34 PROTEIN KINASE A BINDING 19 42 8.322e-06 0.0002148
35 ENZYME ACTIVATOR ACTIVITY 112 471 8.308e-06 0.0002148
36 PROTEIN COMPLEX BINDING 200 935 8.202e-06 0.0002148
37 GTPASE BINDING 76 295 1.294e-05 0.0003248
38 TRANSCRIPTION FACTOR BINDING 121 524 1.599e-05 0.0003909
39 RECEPTOR SIGNALING PROTEIN ACTIVITY 49 172 2.819e-05 0.0006715
40 ENZYME REGULATOR ACTIVITY 201 959 2.91e-05 0.0006758
41 KINASE BINDING 135 606 3.429e-05 0.0007769
42 ACTIVATING TRANSCRIPTION FACTOR BINDING 22 57 3.607e-05 0.0007979
43 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 60 228 5.232e-05 0.00113
44 RECEPTOR SIGNALING PROTEIN SERINE THREONINE KINASE ACTIVITY 30 92 6.858e-05 0.001448
45 RETINOID X RECEPTOR BINDING 10 17 7.491e-05 0.001546
46 METALLOPEPTIDASE ACTIVITY 51 188 8.016e-05 0.001619
47 PHOSPHORIC ESTER HYDROLASE ACTIVITY 87 368 0.0001003 0.001941
48 LIPID BINDING 142 657 9.993e-05 0.001941
49 PHOSPHATIDYLINOSITOL BINDING 53 200 0.0001142 0.002165
50 GUANYLATE KINASE ACTIVITY 8 12 0.00012 0.002186
51 NUCLEOTIDE KINASE ACTIVITY 12 24 0.0001192 0.002186
52 PHOSPHOLIPID BINDING 85 360 0.0001254 0.00224
53 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 17 43 0.0001934 0.00339
54 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 38 133 0.0001985 0.003415
55 BETA CATENIN BINDING 27 84 0.0002028 0.003426
56 MYOSIN BINDING 21 59 0.0002087 0.003463
57 HELICASE ACTIVITY 42 153 0.0002477 0.004037
58 PROTEIN KINASE A REGULATORY SUBUNIT BINDING 9 16 0.0002778 0.004163
59 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 26 81 0.0002704 0.004163
60 GTPASE ACTIVITY 61 246 0.0002736 0.004163
61 PROTEIN TYROSINE PHOSPHATASE ACTIVITY 31 103 0.0002726 0.004163
62 TRANSCRIPTION COREPRESSOR ACTIVITY 56 221 0.0002656 0.004163
63 PHOSPHOPROTEIN PHOSPHATASE ACTIVITY 47 178 0.0002951 0.004351
64 TRANSMITTER GATED CHANNEL ACTIVITY 12 26 0.0003103 0.004505
65 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 23 70 0.0004099 0.005859
66 TRANSLATION REPRESSOR ACTIVITY 10 20 0.000446 0.006184
67 EXTRACELLULAR GLUTAMATE GATED ION CHANNEL ACTIVITY 10 20 0.000446 0.006184
68 GLUTAMATE RECEPTOR ACTIVITY 12 27 0.0004772 0.006519
69 SYNTAXIN BINDING 28 93 0.0005235 0.007048
70 ARF GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 11 24 0.0005954 0.007902
71 SIGNAL SEQUENCE BINDING 15 39 0.0006436 0.008421
72 PROTEIN COMPLEX SCAFFOLD 22 68 0.0006887 0.008764
73 STEROID HORMONE RECEPTOR BINDING 25 81 0.0006797 0.008764
74 PHOSPHATASE ACTIVITY 65 275 0.0007135 0.008957
75 RHO GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 24 77 0.0007376 0.009126
76 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 30 104 0.0007466 0.009126
77 PHOSPHOPROTEIN BINDING 20 60 0.0007764 0.00913
78 GUANYL NUCLEOTIDE BINDING 87 390 0.0007569 0.00913
79 RECEPTOR BINDING 282 1476 0.0007713 0.00913
80 THIOL DEPENDENT UBIQUITIN SPECIFIC PROTEASE ACTIVITY 23 73 0.0007977 0.009263
81 RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING 14 36 0.0008512 0.009763
82 SYNTAXIN 1 BINDING 9 18 0.000868 0.009807
83 HISTONE DEACETYLASE BINDING 30 105 0.0008867 0.009807
84 PHOSPHOTRANSFERASE ACTIVITY PHOSPHATE GROUP AS ACCEPTOR 15 40 0.000878 0.009807
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 292 1151 6.527e-17 3.812e-14
2 GOLGI APPARATUS 340 1445 1.843e-14 5.38e-12
3 NEURON PART 304 1265 3.202e-14 6.232e-12
4 NEURON PROJECTION 237 942 1.789e-13 2.613e-11
5 SYNAPSE 197 754 5.459e-13 6.376e-11
6 CELL PROJECTION 394 1786 2.993e-12 2.914e-10
7 SOMATODENDRITIC COMPARTMENT 166 650 2.575e-10 2.111e-08
8 MEMBRANE REGION 261 1134 2.892e-10 2.111e-08
9 INTRACELLULAR VESICLE 283 1259 6.681e-10 4.335e-08
10 ANCHORING JUNCTION 131 489 8.268e-10 4.39e-08
11 SYNAPSE PART 156 610 8.087e-10 4.39e-08
12 CELL BODY 131 494 1.666e-09 8.107e-08
13 CELL PROJECTION PART 220 946 3.106e-09 1.381e-07
14 DENDRITE 121 451 3.312e-09 1.381e-07
15 PLASMA MEMBRANE REGION 216 929 4.432e-09 1.725e-07
16 GOLGI APPARATUS PART 207 893 1.217e-08 4.444e-07
17 AXON 110 418 5.17e-08 1.776e-06
18 CELL SUBSTRATE JUNCTION 105 398 9.018e-08 2.926e-06
19 PERINUCLEAR REGION OF CYTOPLASM 153 642 1.703e-07 5.234e-06
20 VACUOLE 255 1180 1.889e-07 5.442e-06
21 ENDOSOME 182 793 1.957e-07 5.442e-06
22 APICAL PART OF CELL 95 361 4.121e-07 1.094e-05
23 EARLY ENDOSOME 82 301 5.522e-07 1.402e-05
24 APICAL JUNCTION COMPLEX 43 128 8.412e-07 2.047e-05
25 APICAL PLASMA MEMBRANE 79 292 1.187e-06 2.772e-05
26 GOLGI MEMBRANE 160 703 1.816e-06 4.079e-05
27 CATALYTIC COMPLEX 222 1038 2.628e-06 5.684e-05
28 CELL CELL JUNCTION 96 383 3.624e-06 7.559e-05
29 CYTOPLASMIC REGION 76 287 4.454e-06 8.774e-05
30 TRANSFERASE COMPLEX 158 703 4.507e-06 8.774e-05
31 FILOPODIUM 33 94 5.249e-06 9.888e-05
32 ENDOPLASMIC RETICULUM 327 1631 5.982e-06 0.0001092
33 POSTSYNAPSE 94 378 6.468e-06 0.0001145
34 AXON PART 61 219 6.971e-06 0.0001197
35 CELL LEADING EDGE 88 350 7.952e-06 0.0001327
36 EXCITATORY SYNAPSE 56 197 8.449e-06 0.0001371
37 PRESYNAPSE 74 283 9.581e-06 0.0001512
38 VESICLE MEMBRANE 119 512 1.369e-05 0.0002103
39 NUCLEAR ENVELOPE 100 416 1.546e-05 0.0002316
40 CYTOPLASMIC VESICLE PART 135 601 2.258e-05 0.0003297
41 SYNAPTIC MEMBRANE 68 261 2.446e-05 0.0003485
42 CELL CORTEX 63 238 2.846e-05 0.0003957
43 VACUOLAR PART 151 694 4.311e-05 0.0005855
44 ACTIN BASED CELL PROJECTION 50 181 5.67e-05 0.0007526
45 TRANSPORT VESICLE 82 338 6.189e-05 0.0008033
46 UBIQUITIN LIGASE COMPLEX 66 262 9.619e-05 0.001221
47 MEMBRANE MICRODOMAIN 71 288 0.0001104 0.001372
48 ENDOPLASMIC RETICULUM PART 233 1163 0.000144 0.001716
49 EARLY ENDOSOME MEMBRANE 34 113 0.0001424 0.001716
50 PLASMA MEMBRANE PROTEIN COMPLEX 113 510 0.0001809 0.002113
51 CELL CORTEX PART 35 119 0.0001882 0.002155
52 COATED VESICLE 59 234 0.0002133 0.002396
53 NUCLEAR MEMBRANE 68 280 0.0002428 0.002675
54 NUCLEAR OUTER MEMBRANE ENDOPLASMIC RETICULUM MEMBRANE NETWORK 201 1005 0.0004462 0.004826
55 CORTICAL ACTIN CYTOSKELETON 20 58 0.000473 0.004936
56 VACUOLAR MEMBRANE 125 587 0.0004733 0.004936
57 SITE OF POLARIZED GROWTH 40 149 0.0005607 0.005745
58 NEURON SPINE 34 121 0.0005836 0.005876
59 ENDOSOMAL PART 95 430 0.0006267 0.006203
60 RECEPTOR COMPLEX 75 327 0.0007455 0.007257
61 ENDOCYTIC VESICLE 61 256 0.0008239 0.007888
62 CATION CHANNEL COMPLEX 43 167 0.0009114 0.008585
63 INTRINSIC COMPONENT OF PLASMA MEMBRANE 311 1649 0.0009871 0.00915
64 ENDOPLASMIC RETICULUM TUBULAR NETWORK 7 12 0.00104 0.009488

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 48 139 7.64e-08 3.973e-06
2 FoxO_signaling_pathway_hsa04068 44 132 8.039e-07 2.09e-05
3 MAPK_signaling_pathway_hsa04010 76 295 1.294e-05 0.0002242
4 Endocytosis_hsa04144 65 244 1.726e-05 0.0002243
5 Ras_signaling_pathway_hsa04014 61 232 4.68e-05 0.0004867
6 Gap_junction_hsa04540 29 88 7.263e-05 0.0006295
7 PI3K_Akt_signaling_pathway_hsa04151 84 352 9.334e-05 0.0006934
8 Phosphatidylinositol_signaling_system_hsa04070 31 99 0.0001228 0.0007768
9 Rap1_signaling_pathway_hsa04015 54 206 0.0001344 0.0007768
10 Cellular_senescence_hsa04218 44 160 0.0001712 0.0008903
11 ErbB_signaling_pathway_hsa04012 27 85 0.0002522 0.001192
12 Hippo_signaling_pathway_hsa04390 42 154 0.0002884 0.00125
13 Apelin_signaling_pathway_hsa04371 38 137 0.0003812 0.001525
14 AMPK_signaling_pathway_hsa04152 34 121 0.0005836 0.002168
15 Focal_adhesion_hsa04510 50 199 0.0006747 0.002316
16 Tight_junction_hsa04530 44 170 0.0007127 0.002316
17 cGMP_PKG_signaling_pathway_hsa04022 42 163 0.001022 0.003127
18 Phospholipase_D_signaling_pathway_hsa04072 38 146 0.001417 0.004094
19 Adherens_junction_hsa04520 22 72 0.001607 0.004398
20 Autophagy_animal_hsa04140 34 128 0.001698 0.004414
21 Sphingolipid_signaling_pathway_hsa04071 31 118 0.003177 0.007867
22 Oocyte_meiosis_hsa04114 32 124 0.003713 0.008776
23 p53_signaling_pathway_hsa04115 20 68 0.004185 0.009462
24 HIF_1_signaling_pathway_hsa04066 26 100 0.007525 0.0163
25 Regulation_of_actin_cytoskeleton_hsa04810 47 208 0.008706 0.01811
26 cAMP_signaling_pathway_hsa04024 45 198 0.009081 0.01816
27 TGF_beta_signaling_pathway_hsa04350 22 84 0.01213 0.02336
28 mTOR_signaling_pathway_hsa04150 35 151 0.01462 0.02666
29 Wnt_signaling_pathway_hsa04310 34 146 0.01487 0.02666
30 Mitophagy_animal_hsa04137 17 65 0.02574 0.04461
31 Apoptosis_hsa04210 31 138 0.031 0.05047
32 Hedgehog_signaling_pathway_hsa04340 13 47 0.03106 0.05047
33 Calcium_signaling_pathway_hsa04020 39 182 0.03468 0.05408
34 TNF_signaling_pathway_hsa04668 25 108 0.03536 0.05408
35 Cell_cycle_hsa04110 28 124 0.03654 0.05429
36 Ferroptosis_hsa04216 11 40 0.04698 0.06787
37 VEGF_signaling_pathway_hsa04370 14 59 0.08255 0.116
38 Apoptosis_multiple_species_hsa04215 8 33 0.1498 0.2049
39 Jak_STAT_signaling_pathway_hsa04630 31 162 0.1707 0.2238
40 Cell_adhesion_molecules_.CAMs._hsa04514 28 145 0.1721 0.2238
41 Notch_signaling_pathway_hsa04330 10 48 0.2359 0.2959
42 ECM_receptor_interaction_hsa04512 16 82 0.239 0.2959
43 Hippo_signaling_pathway_multiple_species_hsa04392 6 29 0.3204 0.3874
44 Peroxisome_hsa04146 15 83 0.3558 0.4205
45 Autophagy_other_hsa04136 6 32 0.4127 0.4769
46 ABC_transporters_hsa02010 7 45 0.6022 0.6807
47 Lysosome_hsa04142 19 123 0.6162 0.6817
48 Neuroactive_ligand_receptor_interaction_hsa04080 43 278 0.6388 0.692
49 Phagosome_hsa04145 23 152 0.6614 0.7019
50 Necroptosis_hsa04217 24 164 0.7273 0.7564
51 NF_kappa_B_signaling_pathway_hsa04064 11 95 0.9152 0.9331
52 Cytokine_cytokine_receptor_interaction_hsa04060 35 270 0.9359 0.9359

Quest ID: 6e0c0be258765bb96c565a74f3002259