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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-590-3p ACADL 2.35 0 -2.38 0.18566 miRanda -0.85 2.0E-5 NA
2 hsa-miR-944 ACADL 7.21 0.00082 -2.38 0.18566 MirTarget -0.31 0 NA
3 hsa-miR-16-5p ACOX1 2.94 0 0.41 0.23 miRNATAP -0.11 0.00484 NA
4 hsa-miR-23a-3p ACOX1 0.93 0.01273 0.41 0.23 mirMAP -0.15 0.0033 NA
5 hsa-miR-320a ACOX1 -0.91 0.05656 0.41 0.23 mirMAP -0.14 0.00072 NA
6 hsa-miR-429 ACOX2 6.4 0 -5.25 1.0E-5 miRanda; miRNATAP -0.22 0.00934 NA
7 hsa-miR-125a-3p ACSL1 -0.07 0.92074 -0.26 0.66804 miRanda -0.24 0 NA
8 hsa-miR-130a-3p ACSL1 0.18 0.75775 -0.26 0.66804 MirTarget; miRNATAP -0.23 0.00014 NA
9 hsa-miR-181b-5p ACSL1 1.11 0.02734 -0.26 0.66804 MirTarget -0.27 0.00011 NA
10 hsa-miR-191-5p ACSL1 1.59 0.00074 -0.26 0.66804 miRNAWalker2 validate -0.23 0.00192 NA
11 hsa-miR-192-5p ACSL1 1.78 0.11349 -0.26 0.66804 miRNAWalker2 validate -0.13 4.0E-5 NA
12 hsa-miR-301a-3p ACSL1 1.99 0.00081 -0.26 0.66804 MirTarget; miRNATAP -0.16 0.00641 NA
13 hsa-miR-335-5p ACSL1 0.17 0.8039 -0.26 0.66804 miRNAWalker2 validate -0.25 0 NA
14 hsa-miR-454-3p ACSL1 1.4 0.00366 -0.26 0.66804 MirTarget -0.21 0.00407 NA
15 hsa-miR-93-3p ACSL1 2.63 0 -0.26 0.66804 miRNAWalker2 validate -0.22 0.00116 NA
16 hsa-miR-26a-5p ACSL3 -0.35 0.36204 0.32 0.39192 MirTarget -0.15 0.00824 NA
17 hsa-miR-30e-5p ACSL3 0.78 0.03467 0.32 0.39192 mirMAP -0.22 0.00012 NA
18 hsa-miR-342-3p ACSL3 1.31 0.02072 0.32 0.39192 miRanda -0.11 0.00331 NA
19 hsa-miR-362-3p ACSL3 0.68 0.22615 0.32 0.39192 miRanda -0.1 0.00736 NA
20 hsa-miR-224-3p ACSL4 2.85 0.00018 -0.89 0.13062 MirTarget -0.15 0.0006 NA
21 hsa-miR-224-5p ACSL4 4.27 1.0E-5 -0.89 0.13062 MirTarget -0.11 0.00143 NA
22 hsa-miR-3065-3p ACSL4 1.89 0.03082 -0.89 0.13062 MirTarget; miRNATAP -0.11 0.00535 NA
23 hsa-miR-33a-3p ACSL4 2.06 0.00156 -0.89 0.13062 mirMAP -0.17 0.00096 NA
24 hsa-miR-378a-3p ACSL4 1.47 0.04667 -0.89 0.13062 miRNAWalker2 validate -0.18 5.0E-5 NA
25 hsa-miR-429 ACSL4 6.4 0 -0.89 0.13062 miRanda; miRNATAP -0.15 0.00067 NA
26 hsa-miR-128-3p ACSL5 1.36 0.00408 0.08 0.93844 miRNAWalker2 validate -0.45 0.00014 NA
27 hsa-miR-33a-3p ACSL5 2.06 0.00156 0.08 0.93844 mirMAP -0.32 0.00022 NA
28 hsa-let-7e-5p ACSL6 -0.11 0.81474 0.19 0.87494 miRNATAP -0.44 0.00181 NA
29 hsa-miR-129-5p ACSL6 -2.67 0.00696 0.19 0.87494 miRanda; mirMAP -0.2 0.00383 NA
30 hsa-miR-125a-3p CD36 -0.07 0.92074 -1.67 0.2244 miRanda -0.41 8.0E-5 NA
31 hsa-miR-28-5p CD36 -0.82 0.02212 -1.67 0.2244 miRanda -0.74 0.00092 NA
32 hsa-miR-335-5p CD36 0.17 0.8039 -1.67 0.2244 miRNAWalker2 validate -0.33 0.00423 NA
33 hsa-miR-96-5p CD36 5.63 0 -1.67 0.2244 MirTarget -0.32 0.00245 NA
34 hsa-miR-155-5p CPT1A 2.81 7.0E-5 -0.96 0.06623 miRNAWalker2 validate -0.23 0 NA
35 hsa-miR-3613-5p CPT1A 4.05 0 -0.96 0.06623 mirMAP -0.14 0.00844 NA
36 hsa-miR-139-3p CPT1B -2.55 0.00045 2.08 0.00019 PITA -0.15 0.00038 NA
37 hsa-miR-335-5p FABP4 0.17 0.8039 -2.84 0.28091 miRNAWalker2 validate -0.73 0.00097 NA
38 hsa-miR-338-5p FABP4 -0.11 0.89468 -2.84 0.28091 miRNATAP -0.79 1.0E-5 NA
39 hsa-miR-589-3p FABP4 1.33 0.05263 -2.84 0.28091 MirTarget -0.69 0.00157 NA
40 hsa-miR-744-3p GK 1.08 0.13124 0.99 0.13854 MirTarget -0.25 0 NA
41 hsa-miR-23a-5p HMGCS2 2.87 0.00029 3.1 0.1226 MirTarget -0.38 0.00796 NA
42 hsa-let-7b-5p LPL -0.19 0.65188 -1.41 0.18378 miRNAWalker2 validate -0.43 0.00277 NA
43 hsa-miR-320b LPL 0.2 0.72722 -1.41 0.18378 miRanda -0.31 0.00299 NA
44 hsa-miR-30a-5p ME1 -0.77 0.32049 0.03 0.98183 miRNATAP -0.48 0 NA
45 hsa-miR-30d-5p ME1 0.3 0.38019 0.03 0.98183 miRNATAP -0.85 2.0E-5 NA
46 hsa-miR-34a-5p ME1 0.83 0.04775 0.03 0.98183 miRNAWalker2 validate -0.5 0.00203 NA
47 hsa-miR-501-3p OLR1 1.72 0.00759 4.6 0.00049 TargetScan -0.35 0.00247 NA
48 hsa-miR-2355-5p PDPK1 0.42 0.50215 0.31 0.47594 mirMAP -0.1 0.00842 NA
49 hsa-miR-331-3p PDPK1 2.61 0 0.31 0.47594 miRNAWalker2 validate -0.12 0.00928 NA
50 hsa-miR-335-5p PDPK1 0.17 0.8039 0.31 0.47594 mirMAP -0.12 0.0009 NA
51 hsa-miR-374a-3p PDPK1 0.47 0.30527 0.31 0.47594 mirMAP -0.23 2.0E-5 NA
52 hsa-miR-374b-5p PDPK1 -0.11 0.76489 0.31 0.47594 miRNATAP -0.2 0.00228 NA
53 hsa-miR-424-5p PDPK1 0.21 0.75371 0.31 0.47594 mirMAP -0.11 0.00322 NA
54 hsa-miR-505-3p PDPK1 0.59 0.22694 0.31 0.47594 mirMAP -0.16 0.00135 NA
55 hsa-miR-590-3p PDPK1 2.35 0 0.31 0.47594 miRanda; miRNATAP -0.15 0.00127 NA
56 hsa-miR-7-1-3p PDPK1 1.43 0.00471 0.31 0.47594 mirMAP -0.17 0.00048 NA
57 hsa-miR-708-3p PDPK1 0.78 0.29065 0.31 0.47594 miRNATAP -0.1 0.00176 NA
58 hsa-miR-181a-2-3p PPARA 0.89 0.19167 0.18 0.69545 mirMAP -0.18 0 NA
59 hsa-miR-181b-5p PPARA 1.11 0.02734 0.18 0.69545 miRNATAP -0.16 0.00142 NA
60 hsa-miR-18a-5p PPARA 3.91 0 0.18 0.69545 mirMAP -0.1 0.00866 NA
61 hsa-miR-339-5p PPARA 1.23 0.03075 0.18 0.69545 mirMAP -0.12 0.00999 NA
62 hsa-miR-421 PPARA 1.98 0.00092 0.18 0.69545 miRanda; mirMAP -0.14 0.00132 NA
63 hsa-miR-589-5p PPARA 1.56 0.00033 0.18 0.69545 mirMAP -0.17 0.0038 NA
64 hsa-miR-766-3p PPARA 2.65 1.0E-5 0.18 0.69545 mirMAP -0.14 0.00075 NA
65 hsa-miR-940 PPARA 3.78 5.0E-5 0.18 0.69545 mirMAP -0.12 0.00045 NA
66 hsa-miR-194-3p PPARD 1.92 0.10538 0.42 0.28318 MirTarget -0.1 0 NA
67 hsa-miR-28-5p PPARD -0.82 0.02212 0.42 0.28318 mirMAP -0.19 0.00219 NA
68 hsa-miR-497-5p PPARD -1.44 0.02251 0.42 0.28318 mirMAP -0.1 0.00281 NA
69 hsa-let-7c-5p SCD -2.04 0.02284 3.63 0 MirTarget -0.16 0.00128 NA
70 hsa-let-7e-5p SCD -0.11 0.81474 3.63 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.26 0.00636 NA
71 hsa-miR-10a-5p SCD -0.48 0.59461 3.63 0 miRNAWalker2 validate -0.21 2.0E-5 NA
72 hsa-miR-132-5p SCD -0.14 0.79744 3.63 0 MirTarget -0.28 0.00081 NA
73 hsa-miR-140-5p SCD -0.63 0.12667 3.63 0 MirTarget; PITA -0.36 0.00071 NA
74 hsa-miR-145-3p SCD -2.96 0 3.63 0 mirMAP -0.3 1.0E-5 NA
75 hsa-miR-181c-5p SCD -0.3 0.53753 3.63 0 MirTarget -0.36 7.0E-5 NA
76 hsa-miR-181d-5p SCD -0.53 0.32526 3.63 0 MirTarget -0.22 0.0079 NA
77 hsa-miR-192-5p SCD 1.78 0.11349 3.63 0 miRNAWalker2 validate -0.15 9.0E-5 NA
78 hsa-miR-199a-3p SCD -0.49 0.38855 3.63 0 MirTarget; PITA; miRNATAP -0.25 0.00138 NA
79 hsa-miR-199b-3p SCD -0.48 0.398 3.63 0 MirTarget; PITA; miRNATAP -0.25 0.00142 NA
80 hsa-miR-215-5p SCD 3.67 0.00295 3.63 0 miRNAWalker2 validate -0.1 0.00427 NA
81 hsa-miR-30a-5p SCD -0.77 0.32049 3.63 0 miRNAWalker2 validate -0.2 0.00035 NA
82 hsa-miR-320a SCD -0.91 0.05656 3.63 0 mirMAP -0.24 0.00847 NA
83 hsa-miR-328-3p SCD -0.41 0.43444 3.63 0 miRNAWalker2 validate -0.29 0.00054 NA
84 hsa-miR-664a-5p SCD -0.7 0.21251 3.63 0 MirTarget -0.29 0.00025 NA
85 hsa-miR-126-5p SCD5 -0.42 0.32997 0.5 0.53818 mirMAP -0.29 0.00665 NA
86 hsa-miR-330-3p SCD5 2.49 0.00013 0.5 0.53818 PITA -0.24 0.00076 NA
87 hsa-miR-590-5p SCD5 1.51 0.00239 0.5 0.53818 miRanda -0.24 0.00952 NA
88 hsa-miR-193a-3p SCP2 0.65 0.20713 0.08 0.80465 MirTarget; miRanda -0.14 0.00012 NA
89 hsa-miR-20a-3p SCP2 1.99 0.00062 0.08 0.80465 mirMAP -0.12 0.00023 NA
90 hsa-miR-590-3p SCP2 2.35 0 0.08 0.80465 MirTarget; PITA; miRanda; mirMAP; miRNATAP -0.13 0.00059 NA
91 hsa-miR-590-5p SCP2 1.51 0.00239 0.08 0.80465 mirMAP -0.12 0.00216 NA
92 hsa-miR-769-5p SCP2 0.42 0.34309 0.08 0.80465 miRNAWalker2 validate -0.19 1.0E-5 NA
93 hsa-miR-18a-5p SLC27A1 3.91 0 -1.33 0.0133 mirMAP -0.15 0.00152 NA
94 hsa-miR-421 SLC27A1 1.98 0.00092 -1.33 0.0133 miRanda; mirMAP -0.24 0 NA
95 hsa-miR-940 SLC27A1 3.78 5.0E-5 -1.33 0.0133 MirTarget -0.14 0.0004 NA
96 hsa-miR-125a-5p SLC27A4 -1.32 0.00714 0.92 0.02546 mirMAP; miRNATAP -0.28 0 NA
97 hsa-miR-125b-5p SLC27A4 -2.01 0.00516 0.92 0.02546 mirMAP; miRNATAP -0.13 5.0E-5 NA
98 hsa-miR-452-5p SLC27A6 2.45 0.00115 -4.49 0.00142 MirTarget -0.45 2.0E-5 NA
99 hsa-miR-590-3p SLC27A6 2.35 0 -4.49 0.00142 miRanda; mirMAP -0.53 0.00083 NA
100 hsa-let-7a-3p SORBS1 0.83 0.04681 -5.65 0 miRNATAP -0.59 0 NA
101 hsa-let-7b-3p SORBS1 0.59 0.20051 -5.65 0 miRNATAP -0.43 4.0E-5 NA
102 hsa-let-7g-3p SORBS1 2.1 5.0E-5 -5.65 0 miRNATAP -0.37 5.0E-5 NA
103 hsa-miR-142-5p SORBS1 3.96 0 -5.65 0 PITA; miRNATAP -0.36 0 NA
104 hsa-miR-146b-5p SORBS1 1.88 0.00074 -5.65 0 miRanda -0.27 0.0019 NA
105 hsa-miR-19b-1-5p SORBS1 1.51 0.00147 -5.65 0 mirMAP -0.54 0 NA
106 hsa-miR-205-5p SORBS1 8.08 0 -5.65 0 miRNATAP -0.25 0 NA
107 hsa-miR-22-5p SORBS1 2.38 1.0E-5 -5.65 0 mirMAP -0.35 6.0E-5 NA
108 hsa-miR-320b SORBS1 0.2 0.72722 -5.65 0 mirMAP -0.29 0.00056 NA
109 hsa-miR-320c SORBS1 -0.11 0.854 -5.65 0 mirMAP -0.29 0.00077 NA
110 hsa-miR-339-5p SORBS1 1.23 0.03075 -5.65 0 miRanda -0.46 0 NA
111 hsa-miR-342-3p SORBS1 1.31 0.02072 -5.65 0 miRNATAP -0.5 0 NA
112 hsa-miR-345-5p SORBS1 2.77 4.0E-5 -5.65 0 miRNATAP -0.2 0.00418 NA
113 hsa-miR-3607-3p SORBS1 1.38 0.02401 -5.65 0 mirMAP -0.23 0.00382 NA
114 hsa-miR-421 SORBS1 1.98 0.00092 -5.65 0 miRanda -0.29 0.00033 NA
115 hsa-miR-429 SORBS1 6.4 0 -5.65 0 miRNATAP -0.19 0.00279 NA
116 hsa-miR-584-5p SORBS1 1.18 0.20286 -5.65 0 mirMAP -0.19 0.00033 NA
117 hsa-miR-590-3p SORBS1 2.35 0 -5.65 0 miRanda -0.6 0 NA
118 hsa-miR-590-5p SORBS1 1.51 0.00239 -5.65 0 miRanda -0.5 0 NA
119 hsa-miR-944 SORBS1 7.21 0.00082 -5.65 0 PITA; miRNATAP -0.2 0 NA
120 hsa-miR-130b-3p UBC 3.92 0 -0.47 0.12977 miRNATAP -0.11 0.00021 NA
121 hsa-miR-93-5p UBC 2.66 0 -0.47 0.12977 miRNATAP -0.1 0.00523 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 FATTY ACID METABOLIC PROCESS 19 296 5.887e-29 2.739e-25
2 CELLULAR LIPID METABOLIC PROCESS 22 913 7.318e-25 1.703e-21
3 MONOCARBOXYLIC ACID METABOLIC PROCESS 19 503 1.632e-24 2.444e-21
4 LIPID METABOLIC PROCESS 23 1158 2.101e-24 2.444e-21
5 LONG CHAIN FATTY ACID METABOLIC PROCESS 12 88 6.929e-22 5.374e-19
6 FATTY ACID TRANSPORT 11 56 6.034e-22 5.374e-19
7 ORGANIC ACID METABOLIC PROCESS 20 953 6.496e-21 4.318e-18
8 SMALL MOLECULE METABOLIC PROCESS 22 1767 1.298e-18 7.55e-16
9 MONOCARBOXYLIC ACID TRANSPORT 11 124 6.498e-18 3.359e-15
10 LONG CHAIN FATTY ACID TRANSPORT 8 42 5.613e-16 2.375e-13
11 LIPID LOCALIZATION 12 264 5.495e-16 2.375e-13
12 CELLULAR LIPID CATABOLIC PROCESS 10 151 5.2e-15 2.016e-12
13 ORGANIC ACID TRANSPORT 11 261 2.673e-14 9.566e-12
14 ORGANIC ANION TRANSPORT 12 387 5.354e-14 1.779e-11
15 FATTY ACID CATABOLIC PROCESS 8 73 6.219e-14 1.929e-11
16 FATTY ACID BETA OXIDATION 7 51 5.189e-13 1.42e-10
17 FATTY ACYL COA METABOLIC PROCESS 7 51 5.189e-13 1.42e-10
18 MONOCARBOXYLIC ACID CATABOLIC PROCESS 8 96 6.01e-13 1.554e-10
19 ACYL COA BIOSYNTHETIC PROCESS 7 54 7.916e-13 1.754e-10
20 LIPID CATABOLIC PROCESS 10 247 7.428e-13 1.754e-10
21 THIOESTER BIOSYNTHETIC PROCESS 7 54 7.916e-13 1.754e-10
22 ANION TRANSPORT 12 507 1.303e-12 2.755e-10
23 LIPID BIOSYNTHETIC PROCESS 12 539 2.671e-12 5.404e-10
24 LIPID OXIDATION 7 70 5.28e-12 1.024e-09
25 COENZYME BIOSYNTHETIC PROCESS 8 127 5.909e-12 1.1e-09
26 THIOESTER METABOLIC PROCESS 7 83 1.807e-11 3.114e-09
27 ACYL COA METABOLIC PROCESS 7 83 1.807e-11 3.114e-09
28 COFACTOR BIOSYNTHETIC PROCESS 8 166 5.13e-11 8.525e-09
29 CARBOXYLIC ACID CATABOLIC PROCESS 8 205 2.77e-10 4.296e-08
30 ORGANIC ACID CATABOLIC PROCESS 8 205 2.77e-10 4.296e-08
31 SMALL MOLECULE CATABOLIC PROCESS 9 328 4.039e-10 6.063e-08
32 SINGLE ORGANISM BIOSYNTHETIC PROCESS 14 1340 5.659e-10 8.229e-08
33 NEUTRAL LIPID METABOLIC PROCESS 6 85 1.722e-09 2.428e-07
34 COENZYME METABOLIC PROCESS 8 265 2.112e-09 2.891e-07
35 REGULATION OF LIPID METABOLIC PROCESS 8 282 3.443e-09 4.578e-07
36 ION TRANSPORT 13 1262 3.63e-09 4.691e-07
37 CELLULAR CATABOLIC PROCESS 13 1322 6.37e-09 8.01e-07
38 SULFUR COMPOUND BIOSYNTHETIC PROCESS 7 203 9.89e-09 1.211e-06
39 RESPONSE TO OXYGEN CONTAINING COMPOUND 13 1381 1.078e-08 1.287e-06
40 LIPID MODIFICATION 7 210 1.25e-08 1.454e-06
41 COFACTOR METABOLIC PROCESS 8 334 1.293e-08 1.467e-06
42 OXIDATION REDUCTION PROCESS 11 898 1.497e-08 1.658e-06
43 SINGLE ORGANISM CATABOLIC PROCESS 11 957 2.884e-08 3.121e-06
44 SMALL MOLECULE BIOSYNTHETIC PROCESS 8 443 1.146e-07 1.212e-05
45 MONOCARBOXYLIC ACID BIOSYNTHETIC PROCESS 6 172 1.194e-07 1.234e-05
46 CATABOLIC PROCESS 13 1773 2.098e-07 2.122e-05
47 ORGANIC HYDROXY COMPOUND METABOLIC PROCESS 8 482 2.184e-07 2.15e-05
48 RESPONSE TO NUTRIENT 6 191 2.218e-07 2.15e-05
49 UNSATURATED FATTY ACID METABOLIC PROCESS 5 109 3.899e-07 3.702e-05
50 LIPID HOMEOSTASIS 5 110 4.08e-07 3.797e-05
51 GLYCEROLIPID METABOLIC PROCESS 7 356 4.58e-07 4.179e-05
52 SULFUR COMPOUND METABOLIC PROCESS 7 359 4.846e-07 4.337e-05
53 FATTY ACID BETA OXIDATION USING ACYL COA OXIDASE 3 13 6.962e-07 5.89e-05
54 ALPHA LINOLENIC ACID METABOLIC PROCESS 3 13 6.962e-07 5.89e-05
55 REGULATION OF CHOLESTEROL STORAGE 3 13 6.962e-07 5.89e-05
56 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 5 128 8.669e-07 7.203e-05
57 CARBOXYLIC ACID BIOSYNTHETIC PROCESS 6 270 1.681e-06 0.0001349
58 ORGANIC ACID BIOSYNTHETIC PROCESS 6 270 1.681e-06 0.0001349
59 RESPONSE TO EXTRACELLULAR STIMULUS 7 441 1.916e-06 0.0001511
60 FATTY ACID BETA OXIDATION USING ACYL COA DEHYDROGENASE 3 18 1.977e-06 0.0001533
61 RESPONSE TO FATTY ACID 4 83 5.233e-06 0.0003992
62 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 9 1008 5.865e-06 0.0004401
63 REGULATION OF FATTY ACID METABOLIC PROCESS 4 87 6.314e-06 0.0004664
64 REGULATION OF MACROPHAGE DERIVED FOAM CELL DIFFERENTIATION 3 28 7.864e-06 0.0005629
65 REGULATION OF FATTY ACID OXIDATION 3 28 7.864e-06 0.0005629
66 CELLULAR RESPONSE TO HORMONE STIMULUS 7 552 8.399e-06 0.0005921
67 RESPONSE TO INSULIN 5 205 8.74e-06 0.0005996
68 VERY LONG CHAIN FATTY ACID METABOLIC PROCESS 3 29 8.763e-06 0.0005996
69 RESPONSE TO ENDOGENOUS STIMULUS 10 1450 1.521e-05 0.001026
70 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO CELL PERIPHERY 3 37 1.849e-05 0.001195
71 FATTY ACID BIOSYNTHETIC PROCESS 4 114 1.844e-05 0.001195
72 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE 3 37 1.849e-05 0.001195
73 RESPONSE TO HORMONE 8 893 2.143e-05 0.001366
74 REGULATION OF LIPID STORAGE 3 41 2.528e-05 0.001589
75 RESPONSE TO COLD 3 43 2.921e-05 0.001788
76 REGULATION OF LIPID BIOSYNTHETIC PROCESS 4 128 2.909e-05 0.001788
77 REGULATION OF PLASMA LIPOPROTEIN PARTICLE LEVELS 3 45 3.352e-05 0.002026
78 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO PLASMA MEMBRANE 3 48 4.075e-05 0.002431
79 RESPONSE TO TEMPERATURE STIMULUS 4 148 5.134e-05 0.003024
80 RESPONSE TO ABIOTIC STIMULUS 8 1024 5.703e-05 0.003317
81 ORGANIC HYDROXY COMPOUND TRANSPORT 4 155 6.146e-05 0.003531
82 REGULATION OF DEFENSE RESPONSE 7 759 6.496e-05 0.003686
83 HORMONE MEDIATED SIGNALING PATHWAY 4 158 6.622e-05 0.003712
84 POSITIVE REGULATION OF RESPONSE TO WOUNDING 4 162 7.297e-05 0.004042
85 RESPONSE TO CARBOHYDRATE 4 168 8.403e-05 0.0046
86 REGULATION OF CELLULAR KETONE METABOLIC PROCESS 4 173 9.413e-05 0.005093
87 ORGANIC HYDROXY COMPOUND BIOSYNTHETIC PROCESS 4 175 9.841e-05 0.005263
88 REGULATION OF TRANSPORT 10 1804 9.984e-05 0.005279
89 ALCOHOL METABOLIC PROCESS 5 348 0.0001096 0.005728
90 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 10 1848 0.0001223 0.006323
91 REGULATION OF SEQUESTERING OF TRIGLYCERIDE 2 12 0.0001237 0.006323
92 POSITIVE REGULATION OF DEFENSE RESPONSE 5 364 0.0001353 0.006841
93 CARNITINE METABOLIC PROCESS 2 13 0.000146 0.007152
94 REGULATION OF PLASMA MEMBRANE ORGANIZATION 3 73 0.0001431 0.007152
95 REGULATION OF PHOSPHOLIPID BIOSYNTHETIC PROCESS 2 13 0.000146 0.007152
96 CHEMICAL HOMEOSTASIS 7 874 0.0001571 0.007614
97 AMINO ACID BETAINE TRANSPORT 2 14 0.0001702 0.008082
98 POSITIVE REGULATION OF FATTY ACID OXIDATION 2 14 0.0001702 0.008082
99 POSITIVE REGULATION OF MACROPHAGE DERIVED FOAM CELL DIFFERENTIATION 2 15 0.0001962 0.009223
100 RESPONSE TO ORGANIC CYCLIC COMPOUND 7 917 0.0002114 0.009834
NumGOOverlapSizeP ValueAdj. P Value
1 LONG CHAIN FATTY ACID COA LIGASE ACTIVITY 8 13 6.281e-21 5.835e-18
2 FATTY ACID LIGASE ACTIVITY 8 16 6.264e-20 2.91e-17
3 LIGASE ACTIVITY FORMING CARBON SULFUR BONDS 8 40 3.664e-16 1.135e-13
4 LIGASE ACTIVITY 8 406 5.863e-08 1.362e-05
5 FATTY ACYL COA BINDING 4 31 9.419e-08 1.458e-05
6 FATTY ACID BINDING 4 31 9.419e-08 1.458e-05
7 FATTY ACID TRANSPORTER ACTIVITY 3 12 5.361e-07 7.114e-05
8 ACYL COA DEHYDROGENASE ACTIVITY 3 17 1.649e-06 0.0001915
9 MONOCARBOXYLIC ACID BINDING 4 65 1.962e-06 0.0002025
10 COENZYME BINDING 5 179 4.516e-06 0.0004195
11 LIPID TRANSPORTER ACTIVITY 4 108 1.49e-05 0.001229
12 SULFUR COMPOUND BINDING 5 234 1.657e-05 0.001229
13 ELECTRON CARRIER ACTIVITY 4 112 1.72e-05 0.001229
14 LIPID BINDING 7 657 2.592e-05 0.00172
15 COFACTOR BINDING 5 263 2.904e-05 0.001799
16 OXIDOREDUCTASE ACTIVITY ACTING ON THE CH CH GROUP OF DONORS 3 57 6.835e-05 0.003969
17 LOW DENSITY LIPOPROTEIN RECEPTOR ACTIVITY 2 13 0.000146 0.007692
18 FLAVIN ADENINE DINUCLEOTIDE BINDING 3 74 0.000149 0.007692
19 LONG CHAIN FATTY ACID BINDING 2 14 0.0001702 0.008323
20 ORGANIC ACID BINDING 4 209 0.0001949 0.009052
21 LIPOPROTEIN PARTICLE RECEPTOR ACTIVITY 2 16 0.0002241 0.009913
NumGOOverlapSizeP ValueAdj. P Value
1 MICROBODY PART 7 93 4.085e-11 2.386e-08
2 OUTER MEMBRANE 8 190 1.512e-10 4.414e-08
3 MICROBODY 7 134 5.449e-10 8.84e-08
4 MITOCHONDRION 15 1633 6.055e-10 8.84e-08
5 MITOCHONDRIAL ENVELOPE 11 691 9.722e-10 1.136e-07
6 MICROBODY MEMBRANE 5 58 1.606e-08 1.563e-06
7 MITOCHONDRIAL PART 11 953 2.763e-08 2.305e-06
8 ENVELOPE 11 1090 1.091e-07 7.965e-06
9 MICROBODY LUMEN 3 45 3.352e-05 0.002175
10 NUCLEAR OUTER MEMBRANE ENDOPLASMIC RETICULUM MEMBRANE NETWORK 8 1005 4.993e-05 0.002916
11 LIPID PARTICLE 3 62 8.794e-05 0.004669
12 ENDOPLASMIC RETICULUM PART 8 1163 0.0001393 0.006782

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa03320_PPAR_signaling_pathway 28 70 3.237e-72 5.826e-70
2 hsa00071_Fatty_acid_metabolism 9 43 2.686e-18 2.418e-16
3 hsa04920_Adipocytokine_signaling_pathway 9 68 2.298e-16 1.379e-14
4 hsa04146_Peroxisome 8 79 1.201e-13 5.402e-12
5 hsa01040_Biosynthesis_of_unsaturated_fatty_acids 3 21 3.214e-06 0.0001157
6 hsa00120_Primary_bile_acid_biosynthesis 2 16 0.0002241 0.006722
7 hsa04975_Fat_digestion_and_absorption 2 46 0.001883 0.04842
8 hsa00561_Glycerolipid_metabolism 2 50 0.002221 0.04998
9 hsa04910_Insulin_signaling_pathway 2 138 0.01589 0.286
10 hsa04145_Phagosome 2 156 0.02001 0.312

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 MAGI2-AS3 hsa-let-7a-3p;hsa-let-7g-3p;hsa-miR-142-5p;hsa-miR-19b-1-5p;hsa-miR-205-5p;hsa-miR-320b;hsa-miR-339-5p;hsa-miR-345-5p;hsa-miR-3607-3p;hsa-miR-429;hsa-miR-590-3p 11 SORBS1 Sponge network -4.563 0 -5.647 0 0.647
2 EMX2OS hsa-let-7a-3p;hsa-miR-142-5p;hsa-miR-19b-1-5p;hsa-miR-205-5p;hsa-miR-22-5p;hsa-miR-339-5p;hsa-miR-3607-3p;hsa-miR-421;hsa-miR-584-5p;hsa-miR-590-3p;hsa-miR-944 11 SORBS1 Sponge network -6.205 0.00015 -5.647 0 0.623
3 HAND2-AS1 hsa-let-7a-3p;hsa-let-7g-3p;hsa-miR-19b-1-5p;hsa-miR-205-5p;hsa-miR-22-5p;hsa-miR-339-5p;hsa-miR-345-5p;hsa-miR-3607-3p;hsa-miR-421;hsa-miR-429;hsa-miR-584-5p;hsa-miR-590-3p;hsa-miR-944 13 SORBS1 Sponge network -7.871 0 -5.647 0 0.588
4 MIR143HG hsa-let-7g-3p;hsa-miR-142-5p;hsa-miR-19b-1-5p;hsa-miR-205-5p;hsa-miR-339-5p;hsa-miR-345-5p;hsa-miR-3607-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p 10 SORBS1 Sponge network -6.51 0 -5.647 0 0.58
5 ADAMTS9-AS1 hsa-let-7g-3p;hsa-miR-19b-1-5p;hsa-miR-205-5p;hsa-miR-320b;hsa-miR-339-5p;hsa-miR-421;hsa-miR-429;hsa-miR-584-5p;hsa-miR-590-3p;hsa-miR-590-5p 10 SORBS1 Sponge network -8.573 0.00012 -5.647 0 0.55
6 WT1-AS hsa-let-7g-3p;hsa-miR-142-5p;hsa-miR-19b-1-5p;hsa-miR-205-5p;hsa-miR-22-5p;hsa-miR-339-5p;hsa-miR-421;hsa-miR-429;hsa-miR-590-3p;hsa-miR-944 10 SORBS1 Sponge network -6.875 2.0E-5 -5.647 0 0.547
7 RP11-166D19.1 hsa-let-7g-3p;hsa-miR-142-5p;hsa-miR-19b-1-5p;hsa-miR-339-5p;hsa-miR-345-5p;hsa-miR-3607-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-944 10 SORBS1 Sponge network -4.209 2.0E-5 -5.647 0 0.496

Quest ID: 6e0d90c9428eb28cb93ca02d2eb6892d